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Background: Caring for a child with intellectual disability (ID) has been associated with increased social and psychological burdens. Diagnostic and prognostic uncertainty may enhance emotional stress in families. Method: The present authors assessed the motivations, expectations, mental health, physical health and the quality of life of 194 parents whose children with intellectual disability were undergoing a genetic diagnostic workup. Results: Most parents considered a diagnosis highly relevant for their own emotional relief, their child's therapies and education, or family planning. Parental mental health was significantly lower compared with the normative sample, but physical health was not different. The severity of the child's intellectual disability correlated negatively with their parents' mental and physical health, quality of life, and positively with parental anxiety. Conclusion: Healthcare providers should be aware of the disadvantages facing families with intellectually disabled children. Receiving practical, social and psychological support as well as genetic testing might be particularly relevant for families with severely disabled children.

Inhibitory control is considered a core component of self-regulation. Tremendous advances in early childhood have been attributed to brain maturation processes as well as environmental influences, such as parental co-regulation. Parental self-efficacy represents a key correlate of parenting behaviors and is associated with child outcomes. However, research on the interplay of parental co-regulation, parental self-efficacy and child's inhibitory control in early childhood is scarce. In this study we explore to what extent parents' positive (PCR) and negative co-regulation (NCR) and domain-specific (DSSE) and domain-general (DGSE) self-efficacy beliefs assessed at pre-test (T1) predict toddlers' inhibitory control six weeks later (T2). Furthermore, we examine whether NCR mediates the link between DSSE and parent-reported inhibitory control. Results are based on data from 90 parent-child dyads (children's age: 24-35 months). Parents' PCR, NCR, DSSE and DGSE are assessed via questionnaire. Children's inhibitory control is measured via the Inhibition Scale of the Behavior Rating Inventory of Executive Functions (BRIEF-IN) and a Snack Delay task. Multiple regression analyses reveal that parents' NCR and DSSE, but not PCR and DGSE, significantly predict BRIEF-IN at T2 (controlling for covariates). The indirect effect from parents' DSSE on BRIEF-IN via NCR is not confirmed by the data. No associations are observed regarding children's performance in the Snack Delay task. The present study adds new and important evidence that parents' DSSE and NCR independently predict (parent-reported) inhibitory control in toddlerhood. Parenting interventions should thus not only address parenting practices but target parental self-efficacy beliefs as an important factor, too.

Background: Preterm children have an increased risk regarding self-regulation development. Given the strong link between parenting behaviour (i.e., scaffolding and sensitivity) and children's self-regulation, parental training presents a promising way to counteract the negative consequences of preterm birth. Aims: We explored the effectiveness of parental training by comparing a basic scaffolding training and a combined scaffolding/sensitivity training to an active treatment-control group (stress management). Basic and combined treatments should increase parents' domain-specific self-efficacy (DSSE) and beliefs on parental co-regulation and the promotion of learning (BCL) more than the control treatment should. No such differences were expected for parents' domain-general self-efficacy (DGSE). We examined whether parents of preterm and full-term children benefitted equally from training conditions. Sample(s): A total of 87 parents of full-term and 35 parents of preterm toddlers (24-36 months of age, corrected for prematurity) participated. Methods: Based on a quasi-experimental pre-test--post-test follow-up design, parents were randomly assigned to treatments. A multimethod approach was applied, including self-report, parent-child interactions, and standardized behavioural tasks. The presented study is limited to questionnaire data on parents' DGSE, DSSE, and BCL. Results: An overall increase resulted from pre- to post-test and/or follow-up. Parents' BCL changed significantly stronger in the combined training than in the control group. Parents of preterm and full-term children benefitted equally from basic and combined training. Conclusions: The combined training enhanced BCL among parents of full-term and preterm children the most. If such training also yields improvement on the behavioural level, this finding will advance preterm aftercare.

Objective: We aimed to evaluate determinants of functional outcome after pediatric hemispherotomy in a large and recent multicenter cohort. Methods: We retrospectively investigated the functional outcomes of 455 children who underwent hemispherotomy at 5 epilepsy centers in 2000–2016. We identified determinants of unaided walking, voluntary grasping with the hemiplegic hand, and speaking through Bayesian multivariable regression modeling using missing data imputation. Results: Seventy‐five percent of children were seizure‐free, and 44% stopped antiseizure medication at a 5.1‐year mean follow‐up (range = 1–17.1). Seventy‐seven percent of children could walk unaided, 8% could grasp voluntarily, and 68% could speak at the last follow‐up. Children were unlikely to walk when they had contralateral magnetic resonance imaging (MRI) abnormalities (40/73, p = 0.04), recurrent seizures following hemispherotomy (62/109, p = 0.04), and moderately (50/61, p = 0.03) or severely impaired (127/199, p = 0.001) postsurgical intellectual functioning, but were likely to walk when they were older at outcome determination (p = 0.01). Children were unlikely to grasp voluntarily with the hand contralateral to surgery when they had Rasmussen encephalitis (0/61, p = 0.001) or Sturge–Weber syndrome (0/32, p = 0.007). Children were unlikely to speak when they had contralateral MRI abnormalities (30/69, p = 0.002) and longer epilepsy duration (p = 0.01), but likely to speak when they had Sturge–Weber syndrome (29/35, p = 0.01), were older at surgery (p = 0.04), and were older at outcome determination (p < 0.001). Interpretation: Etiology and bilaterality of structural brain abnormalities were key determinants of functional outcome after hemispherotomy. Longer epilepsy duration affected language outcomes. Not surprisingly, walking and talking ability increased with older age at outcome evaluation. ANN NEUROL 2024;95:377–387 [ABSTRACT FROM AUTHOR]

Epilepsy surgery is a very effective treatment option for children and adolescents with drugresistant structural epilepsy, resulting in seizure freedom in the majority of cases. Beyond seizure freedom, the postsurgical stabilization or even improvement of cognitive development constitutes a fundamental objective. This study aims to address key features of cognitive development in the context of pediatric epilepsy surgery. Many surgical candidates present with severe developmental delay and cognitive deficits prior to surgery. Recent studies support that global cognitive development remains stable after surgery. Individual developmental trajectories are determined by the degree of presurgical developmental impairment, age at surgery, seizure freedom, antiepileptic drug tapering, and other case-specific factors. Compared with adults, children may better compensate for temporary postsurgical deficits in circumscribed cognitive functions such as memory. Particularly for left-sided temporal resections, children present a clear advantage in termsof postsurgical recovery with regard to verbal learning compared with adults. In the case of severe presurgical developmental impairment, minimal postsurgical improvements are often not measurable, although they are evident to patients' families and have a large impact on their quality of life. Multicenter studies with a standardized assessment protocol and longer follow-up intervals are urgently called for to provide deeper insights into the cognitive development after epilepsy surgery, to analyze the interaction between different predictors, and to facilitate the selection of appropriate candidates aswell as the counseling of families. [ABSTRACT FROM AUTHOR]