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16 results on '"Reuter, Hanna"'

1. Featured Cover

Author

Ruparelia, Avnika A., primary, Salavaty, Adrian, additional, Barlow, Christopher K., additional, Lu, Yansong, additional, Sonntag, Carmen, additional, Hersey, Lucy, additional, Eramo, Matthew J., additional, Krug, Johannes, additional, Reuter, Hanna, additional, Schittenhelm, Ralf B., additional, Ramialison, Mirana, additional, Cox, Andrew, additional, Ryan, Michael T., additional, Creek, Darren J., additional, Englert, Christoph, additional, and Currie, Peter D., additional

Published
2024
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2. The African killifish: A short‐lived vertebrate model to study the biology of sarcopenia and longevity.

Author

Ruparelia, Avnika A., Salavaty, Adrian, Barlow, Christopher K., Lu, Yansong, Sonntag, Carmen, Hersey, Lucy, Eramo, Matthew J., Krug, Johannes, Reuter, Hanna, Schittenhelm, Ralf B., Ramialison, Mirana, Cox, Andrew, Ryan, Michael T., Creek, Darren J., Englert, Christoph, and Currie, Peter D.

Subjects
KILLIFISHES, SARCOPENIA, LONGEVITY, LOW-calorie diet, BIOLOGY, VERTEBRATES
Abstract

Sarcopenia, the age‐related decline in muscle function, places a considerable burden on health‐care systems. While the stereotypic hallmarks of sarcopenia are well characterized, their contribution to muscle wasting remains elusive, which is partly due to the limited availability of animal models. Here, we have performed cellular and molecular characterization of skeletal muscle from the African killifish—an extremely short‐lived vertebrate—revealing that while many characteristics deteriorate with increasing age, supporting the use of killifish as a model for sarcopenia research, some features surprisingly reverse to an "early‐life" state in the extremely old stages. This suggests that in extremely old animals, there may be mechanisms that prevent further deterioration of skeletal muscle, contributing to an extension of life span. In line with this, we report a reduction in mortality rates in extremely old killifish. To identify mechanisms for this phenomenon, we used a systems metabolomics approach, which revealed that during aging there is a striking depletion of triglycerides, mimicking a state of calorie restriction. This results in the activation of mitohormesis, increasing Sirt1 levels, which improves lipid metabolism and maintains nutrient homeostasis in extremely old animals. Pharmacological induction of Sirt1 in aged animals was sufficient to induce a late life‐like metabolic profile, supporting its role in life span extension in vertebrate populations that are naturally long‐lived. Collectively, our results demonstrate that killifish are not only a novel model to study the biological processes that govern sarcopenia, but they also provide a unique vertebrate system to dissect the regulation of longevity. [ABSTRACT FROM AUTHOR]

Published
2024
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5. The African killifish: A short‐lived vertebrate model to study the biology of sarcopenia and longevity

Author

Ruparelia, Avnika A., primary, Salavaty, Abbas, additional, Barlow, Christopher K., additional, Lu, Yansong, additional, Sonntag, Carmen, additional, Hersey, Lucy, additional, Eramo, Matthew J., additional, Krug, Johannes, additional, Reuter, Hanna, additional, Schittenhelm, Ralf B., additional, Ramialison, Mirana, additional, Cox, Andrew, additional, Ryan, Michael T., additional, Creek, Darren J., additional, Englert, Christoph, additional, and Currie, Peter D., additional

Published
2023
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8. The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea

Author

Schmidt, David, Reuter, Hanna, Hüttner, Katja, Ruhe, Larissa, Rabert, Franziska, Seebeck, Florian, Irimia, Manuel, and Solana, Jordi

Abstract

In multicellular organisms, cell type diversity and fate depend on specific sets of transcript isoforms generated by post-transcriptional RNA processing. Here, we used Schmidtea mediterranea, a flatworm with extraordinary regenerative abilities and a large pool of adult stem cells, as an in vivo model to study the role of Uridyl-rich small nuclear RNAs (UsnRNAs), which participate in multiple RNA processing reactions including splicing, in stem cell regulation. We characterized the planarian UsnRNA repertoire, identified stem cell-enriched variants and obtained strong evidence for an increased rate of UsnRNA 3’-processing in stem cells compared to their differentiated counterparts. Consistently, components of the Integrator complex showed stem cell-enriched expression and their depletion by RNAi disrupted UsnRNA processing resulting in global changes of splicing patterns and reduced processing of histone mRNAs. Interestingly, loss of Integrator complex function disrupted both stem cell maintenance and regeneration of tissues. Our data show that the function of the Integrator complex in UsnRNA 3’-processing is conserved in planarians and essential for maintaining their stem cell pool. We propose that cell type-specific modulation of UsnRNA composition and maturation contributes to in vivo cell fate choices, such as stem cell selfrenewal in planarians.

Published
2018

9. Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish

Author

Sanz-Morejón, Andrés, primary, García-Redondo, Ana B., additional, Reuter, Hanna, additional, Marques, Inês J., additional, Bates, Thomas, additional, Galardi-Castilla, María, additional, Große, Andreas, additional, Manig, Steffi, additional, Langa, Xavier, additional, Ernst, Alexander, additional, Piragyte, Indre, additional, Botos, Marius-Alexandru, additional, González-Rosa, Juan Manuel, additional, Ruiz-Ortega, Marta, additional, Briones, Ana M., additional, Salaices, Mercedes, additional, Englert, Christoph, additional, and Mercader, Nadia, additional

Published
2019
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12. Generic wound signals initiate regeneration in missing-tissue contexts

Author

Owlarn, Suthira, primary, Klenner, Felix, additional, Schmidt, David, additional, Rabert, Franziska, additional, Tomasso, Antonio, additional, Reuter, Hanna, additional, Mulaw, Medhanie A., additional, Moritz, Sören, additional, Gentile, Luca, additional, Weidinger, Gilbert, additional, and Bartscherer, Kerstin, additional

Published
2017
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