1. Toxicity and outcome of children with treatment related acute myeloid leukemia.
- Author
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Tabori U, Revach G, Nathan PC, Strahm B, Rachlis A, Shago M, Grant R, Doyle J, and Malkin D
- Subjects
- Adolescent, Antineoplastic Combined Chemotherapy Protocols adverse effects, Child, Disease Progression, Female, Hematopoietic Stem Cell Transplantation adverse effects, Humans, Leukemia, Myeloid, Acute chemically induced, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute mortality, Male, Myelodysplastic Syndromes chemically induced, Myelodysplastic Syndromes genetics, Myelodysplastic Syndromes mortality, Neoplasms, Second Primary chemically induced, Neoplasms, Second Primary genetics, Neoplasms, Second Primary mortality, Survival Analysis, Survival Rate, Leukemia, Myeloid, Acute therapy, Myelodysplastic Syndromes therapy, Neoplasms, Second Primary therapy
- Abstract
Background: The aim of this study was to evaluate the clinical course and outcome of children with treatment related acute myeloid leukemia (tAML) and compare them to children with primary AML (pAML)., Procedure: We retrospectively reviewed the demographic, treatment, toxicity, and outcome data of children with tAML and treatment related myelodysplastic syndrome (tMDS), treated at our institution between 1975 and 2005. We compared these parameters with matched controlled children with pAML. Finally we compared overall survival (OS) for tAML with all pAML children treated at the study era in our institution., Results: Twenty-one patients with tAML (n = 19) and tMDS (n = 2) were identified. Three years event-free survival (EFS) and OS were both 14 +/- 8%. Compared to pAML patients, tAML had a higher rate of adverse cytogenetics (P < 0.008) and inferior OS (P = 0.027) but no significant difference in treatment toxicity or death. All survivors were treated with allogeneic hematopoietic stem cell transplantation (HSCT)., Conclusions: In this population based report of pediatric tAML, outcome was poor and was related to a higher probability of poor cytogenetic features rather than excessive toxicities or inability to deliver therapy. HSCT should be considered for patients with tAML. These preliminary findings should set the stage for prospective cooperative studies., ((c) 2007 Wiley-Liss, Inc.)
- Published
- 2008
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