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548 results on '"Revheim, Mona-Elisabeth"'

3. Towards Understanding the Survival of Patients with High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms: An Investigation of Ensemble Feature Selection in the Prediction of Overall Survival

Author

Jenul, Anna, Stokmo, Henning Langen, Schrunner, Stefan, Revheim, Mona-Elisabeth, Hjortland, Geir Olav, and Tomic, Oliver

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

Determining the most informative features for predicting the overall survival of patients diagnosed with high-grade gastroenteropancreatic neuroendocrine neoplasms is crucial to improve individual treatment plans for patients, as well as the biological understanding of the disease. Recently developed ensemble feature selectors like the Repeated Elastic Net Technique for Feature Selection (RENT) and the User-Guided Bayesian Framework for Feature Selection (UBayFS) allow the user to identify such features in datasets with low sample sizes. While RENT is purely data-driven, UBayFS is capable of integrating expert knowledge a priori in the feature selection process. In this work we compare both feature selectors on a dataset comprising of 63 patients and 134 features from multiple sources, including basic patient characteristics, baseline blood values, tumor histology, imaging, and treatment information. Our experiments involve data-driven and expert-driven setups, as well as combinations of both. We use findings from clinical literature as a source of expert knowledge. Our results demonstrate that both feature selectors allow accurate predictions, and that expert knowledge has a stabilizing effect on the feature set, while the impact on predictive performance is limited. The features WHO Performance Status, Albumin, Platelets, Ki-67, Tumor Morphology, Total MTV, Total TLG, and SUVmax are the most stable and predictive features in our study.

Published
2023
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4. Exploring protocol development: Implementing systematic contextual memory to enhance real-time fMRI neurofeedback

Author

Fagerland Steffen Maude, Berntsen Henrik Røsholm, Fredriksen Mats, Endestad Tor, Skouras Stavros, Rootwelt-Revheim Mona Elisabeth, and Undseth Ragnhild Marie

Subjects
rtfmri-nf, adhd, tourette’s syndrome, vr, Medicine (General), R5-920
Abstract

The goal of this study was to explore the development and implementation of a protocol for real-time fMRI neurofeedback (rtfMRI-nf) and to assess the potential for enhancing the selective brain activation using stimuli from Virtual Reality (VR). In this study we focused on two specific brain regions, supplementary motor area (SMA) and right inferior frontal gyrus (rIFG). Publications by other study groups have suggested impaired function in these specific brain regions in patients with the diagnoses Attention Deficit Hyperactivity Disorder (ADHD) and Tourette’s Syndrome (TS). This study explored the development of a protocol to investigate if attention and contextual memory may be used to systematically strengthen the procedure of rtfMRI-nf.

Published
2024
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41. Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?

Author

Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, Barrio, Jorge R., Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, and Barrio, Jorge R.

Abstract

The amyloid cascade hypothesis for Alzheimer’s disease is still alive, although heavily challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis’ claim that the protein amyloid-beta is the cause of the disease. Two antibodies, aducanumab and lecanemab, have been approved by the U.S. Food and Drug Administration, while a third, donanemab, is under review. The main argument for the FDA approvals is a presumed therapy-induced removal of cerebral amyloid deposits. Lecanemab and donanemab are also thought to cause some statistical delay in the determination of cognitive decline. However, clinical efficacy that is less than with conventional treatment, selection of amyloid-positive trial patients with non-specific amyloid-PET imaging, and uncertain therapy-induced removal of cerebral amyloids in clinical trials cast doubt on this anti-Alzheimer’s antibody therapy and hence on the amyloid hypothesis, calling for a more thorough investigation of the negative impact of this type of therapy on the brain.

Published
2024

48. Bacterial Brain Abscesses Expand Despite Effective Antibiotic Treatment: A Process Powered by Osmosis Due to Neutrophil Cell Death

Author

Dahlberg, Daniel, primary, Holm, Sverre, additional, Sagen, Ellen Margaret Lund, additional, Michelsen, Annika Elisabet, additional, Stensland, Maria, additional, de Souza, Gustavo Antonio, additional, Müller, Ebba Gløersen, additional, Connelly, James Patrick, additional, Revheim, Mona-Elisabeth, additional, Halvorsen, Bente, additional, and Hassel, Bjørnar, additional

Published
2023
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50. Comparison of 18F-sodium fluoride uptake in the whole bone, pelvis, and femoral neck of multiple myeloma patients before and after high-dose therapy and conventional-dose chemotherapy

Author

Zirakchian Zadeh, Mahdi, Østergaard, Brian, Raynor, William Y., Revheim, Mona-Elisabeth, Seraj, Siavash Mehdizadeh, Acosta-Montenegro, Oswaldo, Ayubcha, Cyrus, Yellanki, Dani P., Al-Zaghal, Abdullah, Nielsen, Anne L., Constantinescu, Caius M., Gerke, Oke, Werner, Thomas J., Zhuang, Hongming, Abildgaard, Niels, Høilund-Carlsen, Poul Flemming, and Alavi, Abass

Published
2020
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