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Keywords: ADC; xanthate chemistry; gaseous olefins; amide coupling; linker; Maytansinoids; mercapto acid EN ADC xanthate chemistry gaseous olefins amide coupling linker Maytansinoids mercapto acid 2177 2185 9 07/03/23 20230718 NES 230718 Antibody-Drug Conjugates (ADC) belong to a novel class of anti-cancer drugs whose principle is based on targeted therapy approaches. ADC, xanthate chemistry, gaseous olefins, amide coupling, Maytansinoids, mercapto acid, linker Finally, a masked I N i -methylamino acid was coupled successfully to the acid, highlighting the feasibility of our method in ADC chemistry. Amide Coupling; General Procedure 4-((Ethoxycarbonothioyl)thio)-4-methylpentanoic acid ( B 23 b ; 0.75 g, 3.2 mmol, 1.0 equiv.) was dissolved in EtOAc (20 mL) and the resulting solution was cooled to 0-5 °C. [Extracted from the article]