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48 results on '"Reyelt, Lara"'

1. Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation

Author

Swain, Lija, Bhave, Shreyas, Qiao, Xiaoying, Reyelt, Lara, Everett, Kay D., Awata, Junya, Raghav, Rahul, Powers, Sarah N., Sunagawa, Genya, Natov, Peter S., Mahmoudi, Elena, Warner, Mary, Couper, Greg, Kawabori, Masashi, Miyashita, Satoshi, Aryaputra, Tejasvi, Huggins, Gordon S., Chin, Michael T., and Kapur, Navin K.

Published
2024
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12. Combining VA-ECMO And Impella (EC-Pella) Before Reperfusion Mitigates Left Ventricular Loading And Injury Due To VA-ECMO In Acute Myocardial Infarction

Author

Everett, Kay D., primary, Swain, Lija, additional, Reyelt, Lara, additional, Majumdar, Monica, additional, Qiao, Xiaoying, additional, Bhave, Shreyas, additional, Warner, Mary, additional, Mahmoudi, Elena, additional, Surks, Will, additional, Aryaputra, Tejasvi, additional, Goel, Siya, additional, and Kapur, Navin, additional

Published
2023
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16. Combining VA-ECMO and Impella (EC-Pella) Before Reperfusion Mitigates Left Ventricular Loading and Injury Due to VA-ECMO in Acute Myocardial Infarction

Author

Everett, Kay D., primary, Swain, Lija, additional, Reyelt, Lara, additional, Majumdar, Monica, additional, Qiao, Xiaoying, additional, Bhave, Shreyas, additional, Warner, Mary, additional, Mahmoudi, Elena, additional, Surks, Will, additional, Aryaputra, Tejasvi, additional, Goel, Siya, additional, and Kapur, Navin K., additional

Published
2022
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17. Combining VA-ECMO And Impella (EC-Pella) Before Reperfusion Mitigates Left Ventricular Loading And Injury Due To VA-ECMO In Acute Myocardial Infarction

Author

Everett, Kay, primary, Swain, Lija, additional, Reyelt, Lara, additional, Majumdar, Monica, additional, Qiao, Xiaoying, additional, Bhave, Shreyas, additional, Warner, Mary, additional, Mahmoudi, Elena, additional, Surks, Will, additional, Aryaputra, Tejasvi, additional, Goel, Siya, additional, and Kapur, Navin, additional

Published
2022
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18. TRANS-VALVULAR UNLOADING REDUCES ANAEROBIC GLYCOLYSIS BEFORE REPERFUSION AND PRESERVES ENERGY SUBSTRATE UTILIZATION AFTER REPERFUSION IN MODELS OF ACUTE MYOCARDIAL INFARCTION

Author

Swain, Lija, primary, Qiao, Xiaoying, additional, Everett, Kay, additional, Bhave, Shreyas, additional, Reyelt, Lara, additional, Aryaputra, Tejasvi, additional, Surks, William, additional, Goel, Siya, additional, Zweck, Elric, additional, Diakos, Nikolaos, additional, and Kapur, Navin, additional

Published
2022
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19. CRT-600.10 Combining VA-ECMO and Impella (EC-Pella) Before Reperfusion Mitigates Left Ventricular Loading and Injury Due to VA-ECMO in Acute Myocardial Infarction

Author

Everett, Kay D., primary, Swain, Lija, additional, Reyelt, Lara, additional, Majumdar, Monica, additional, Qiao, Xiaoying, additional, Bhave, Shreyas, additional, Warner, Mary, additional, Mahmoudi, Elena, additional, Surks, Will, additional, Aryaputra, Tejasvi, additional, Goel, Siya, additional, and Kapur, Navin K., additional

Published
2022
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21. TCT-467 Prolonged Occlusion of the Superior Vena Cava Using the PreCardia System Reduces Cardiac Filling and Renal Venous Pressures Without Causing Cerebral Injury in a Preclinical Model of Systemic Congestion.

Author

Kapur, Navin, Reyelt, Lara, Stolyarov, Arik, Bhave, Shreyas, Mahmoudi, Elena, Curran, Jerry, Unudurthi, Sathya, Qiao, Xiaoying, and Swain, Lija

Subjects
*VENA cava superior, *VENOUS pressure, *ANIMAL models in research, *WOUNDS & injuries
Published
2024
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25. Myocardial Injury Promotes Matrix Metalloproteinase-9 Activity in the Renal Cortex in Preclinical Models of Acute Myocardial Infarction

Author

Qiao, Xiaoying, primary, Bhave, Shreyas, additional, Swain, Lija, additional, Zweck, Elric, additional, Reyelt, Lara, additional, Crowley, Paige, additional, Annamalai, Shiva K., additional, Chennjorwala, Aditya, additional, Esposito, Michele, additional, Razavi, Allen, additional, Foroutanjazi, Sina, additional, Machen, Cody, additional, Thayer, Katherine, additional, Jorde, Lena, additional, Karas, Richard H., additional, and Kapur, Navin K., additional

Published
2021
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26. Transvalvular Ventricular Unloading Before Reperfusion in Acute Myocardial Infarction

Author

Swain, Lija, primary, Reyelt, Lara, additional, Bhave, Shreyas, additional, Qiao, Xiaoying, additional, Thomas, Corinne J., additional, Zweck, Elric, additional, Crowley, Paige, additional, Boggins, Courtney, additional, Esposito, Michele, additional, Chin, Michael, additional, Karas, Richard H., additional, O’Neill, William, additional, and Kapur, Navin K., additional

Published
2020
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27. Duodenal Cannulation in Pigs (Sus scrofa) as a Drug Delivery Method

Author

Beale, Corinna N, Reyelt, Lara A, Bogins, Courtney A, Chan, Nathan YL, and Perkins, Scott E

Subjects
Duodenum, Drug Administration Routes, Sus scrofa, Swine Model, Animals, Female, Vascular Access Devices, Catheterization
Abstract

Currently available animal models for delivery of drug capsules and pharmacokinetic testing are limited by either intersubject variability in gastric emptying time or the need to sedate animals when using targeted delivery methods of drug capsules. With the increasing development of large-molecule biologics, better in vivo models for testing the pharmacokinetics of capsule-delivered drugs are urgently needed. To this end, we made engineering modifications to an existing bovine surgical cannula device, successfully implanted this modified cannula into pigs, and delivered drug capsules directly to the proximal duodenum. In our porcine model, capsule insertion and serial blood samples were all acquired without the use of sedatives. Furthermore, we were able to maintain cannulated pigs for weekly pharmacokinetic testing for more than 18 mo, with minimal postoperative complications. This study demonstrates a novel and effective porcine model of sedation-free drug delivery and blood collection that eliminates inconsistencies associated with models that require either gastric emptying or animal sedation.

Published
2018

28. Intermittent Occlusion of the Superior Vena Cava Reduces Cardiac Filling Pressures in Preclinical Models of Heart Failure

Author

Kapur, Navin K., primary, Reyelt, Lara, additional, Crowley, Paige, additional, Richey, Lauren, additional, McCarthy, John, additional, Annamalai, Shiva, additional, Newman, Sarah, additional, Jorde, Lena, additional, Forotuanjazi, Sina, additional, Razavi, Allen, additional, Lenihan, Tim, additional, Burkhoff, Daniel, additional, and Karas, Richard H., additional

Published
2019
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29. Left Ventricular Unloading Increases the Coronary Collateral Flow Index Before Reperfusion and Reduces Infarct Size in a Swine Model of Acute Myocardial Infarction

Author

Briceno, Natalia, primary, Annamalai, Shiva K., additional, Reyelt, Lara, additional, Crowley, Paige, additional, Qiao, Xiaoying, additional, Swain, Lija, additional, Pedicini, Robert, additional, Foroutanjazi, Sina, additional, Jorde, Lena, additional, Yesodharan, Gemini, additional, Perera, Divaka, additional, and Kapur, Navin K., additional

Published
2019
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31. TCT-594 Blunting the Double-Edged Sword of Reperfusion: Left Ventricular Unloading Protects the Functional Integrity of Mitochondrial Complex I in Preclinical Models of Ischemia With and Without Reperfusion

Author

Swain, Lija, primary, Qiao, Xiaoying, additional, Reyelt, Lara, additional, Chennojwala, Aditya, additional, Crowley, Paige, additional, Chin, Michael, additional, Thomas, Corinne, additional, Bhave, Shreyas, additional, and Kapur, Navin, additional

Published
2019
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33. Abstract 586: VA-ECMO Increases Urinary Levels of the Biomarker Kidney Injury Marker-1 (KIM-1) in a Preclinical Model of Acute Myocardial Infarction

Author

Qiao, Xiaoying, primary, Swain, Lija, additional, Reyelt, Lara, additional, Machen, Cody, additional, Jarrah, Andrew, additional, Chennjorwala, Aditya, additional, Crowley, Paige, additional, Annamalai, Shiva, additional, Foroutanjazi, Sina, additional, Razavi, Allen, additional, and Kapur, Navin, additional

Published
2019
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37. PRIMARY LV UNLOADING WITH A TRANS-VALVULAR AXIAL FLOW PUMP REDUCES INFARCT SIZE BY INCREASING MYOCARDIAL LEVELS OF STROMAL DERIVED FACTOR ONE ALPHA (SDF-1A) IN ACUTE MYOCARDIAL INFARCTION AND LIMITS THE DEVELOPMENT OF ISCHEMIC HEART FAILURE

Author

Esposito, Michele, primary, Zhang, Yali, additional, Qiao, Xiaoying, additional, Reyelt, Lara, additional, Morine, Kevin, additional, Annamalai, Shiva, additional, Bogins, Courtney, additional, Natov, Peter, additional, Patel, Ayan, additional, Rowin, Ethan, additional, Karas, Richard, additional, and Kapur, Navin, additional

Published
2018
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38. CRT-600.11 Uncoupling Cardio-renal Hemodynamics in Heart Failure: Effects of an Intra-aortic Micro-axial Flow Pump in a Swine Model of Ischemic Heart Failure

Author

Annamalai, Shiva K., primary, Esposito, Michele, additional, Reyelt, Lara, additional, Natov, Peter, additional, Jorde, Lena, additional, Chouinard, Paul, additional, Liu, Qian, additional, Anand, Umang, additional, Heuring, Jason, additional, Clifton, Will, additional, and Kapur, Navin K., additional

Published
2018
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42. Abstract 452: Primary Left Ventricular Unloading Reduces Infarct Size by Increasing Myocardial Levels of Stromal Derived Factor One Alpha (SDF1a) in Acute Myocardial Infarction

Author

Zhang, Yali, primary, Esposito, Michele, additional, Qiao, Xiaoying, additional, Paruchuri, Vikram, additional, Mackey, Emily, additional, Morine, Kevin, additional, Schnitzler, Gavin, additional, Reyelt, Lara, additional, Boggins, Courtney, additional, Josephy, Noam, additional, Karas, Richard H, additional, and Kapur, Navin K, additional

Published
2017
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43. Hemodynamic Effects of Left Atrial or Left Ventricular Cannulation for Acute Circulatory Support in a Bovine Model of Left Heart Injury

Author

Kapur, Navin K., primary, Paruchuri, Vikram, additional, Pham, Duc Thinh, additional, Reyelt, Lara, additional, Murphy, Barbara, additional, Beale, Corinna, additional, Bogins, Courtney, additional, Wiener, Daniel, additional, Nilson, James, additional, Esposito, Michele, additional, Perkins, Scott, additional, Perides, George, additional, and Karas, Richard H., additional

Published
2015
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45. Abstract 16540: A Novel Superior Vena Caval Occlusion Catheter System Reduces Biventricular Filling Pressures While Maintaining Cardiac Output In A Model Of Acute Congestive Heart Failure

Author

Kapur, Navin K, Karas, Richard H, Reyelt, Lara A, Lenihan, Tim, and Burkhoff, Daniel

Abstract

Introduction:Congestion is a major determinant of clinical outcomes in heart failure (HF). Diuretics, ultrafiltration, inotropes, or vasodilators have not improved clinical outcomes. We recently reported that short-term superior vena cava (SVC) occlusion rapidly reduces cardiac filling pressures and maintains cardiac output and systemic pressure in patients with HF. The preCARDIA system is a catheter-mounted SVC occlusion balloon and controller capable of intermittently occluding the SVC over prolonged periods of time (Fig 1A).Hypothesis:We hypothesized that the preCARDIA system would reduce cardiac filling pressures without causing hemodynamic compromise or neurologic damage in a swine model of congestive HF.Methods:We employed a model of post-acute myocardial infarction (AMI) HF. The preCARDIA device was introduced and activated to occlude the SVC for 5 minutes followed by 30 seconds of balloon collapse for 18 hours total (Fig 1B).Results:Device insertion and activation was successful in all 3 pigs. LAD occlusion and volume loading increased right atrial (RA:11?2 to 16?3, p<0.01) and pulmonary capillary wedge pressures (PCWP:11?3 to 18?3, p<0.01). At 6, 12, and 18 hours after initiation of SVC therapy, right internal jugular (IJ) venous pressure increased; RA, PCWP, and mean pulmonary artery (PA) pressures decreased while cardiac output (CO) remained unchanged (Fig 1C). Mean arterial pressure (MAP) remained above 60 mmHg during SVC therapy. Gross and histologic pathology showed no evidence of increased cerebral or ocular edema, no pulmonary emboli or cardiac damage, and no evidence of SVC damage or thrombosis due to the preCARDIA device.Conclusions:Intermittent SVC occlusion with the preCARDIA system is a novel approach to mechanically reduce biventricular pressures while maintaining cardiac output in HF. The VENUS-HF trial will now test the safety and feasibility of the preCARDIA device in patients with congestive heart failure.

Published
2019
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46. Abstract 14326: Left Ventricular Unloading Preserves Energy Substrate Utilization and Protects the Functional Integrity of Mitochondrial Complex I in Preclinical Models of Ischemia With and Without Reperfusion

Author

Swain, Lija, Qiao, Xiaoying, Reyelt, Lara A, Chennojwala, Aditya, Bhave, Shreyas, Chin, Michael T, Thomas, Corinne, Annamalai, Shiva, Crowley, Paige, and Kapur, Navin K

Abstract

Mechanical unloading before reperfusion limits infarct size in preclinical models and is currently under clinical investigation in acute myocardial infarction (AMI). The impact of left ventricular (LV) unloading on energetics or mitochondrial function in AMI is unknown. We hypothesized that LV unloading preserves myocardial metabolism and mitochondrial function in AMI. AMI was induced by balloon occlusion of the LAD artery for 120 minutes in adult male swine (n=5/group) followed by reperfusion for 180 minutes. After 90 minutes of occlusion, animals were assigned to 30 minutes of continued occlusion then immediate reperfusion (IR) or 30 minutes of LV unloading with persistent occlusion before reperfusion. Compared to IR, unloading reduced infarct size normalized to the area at risk by 41?6% (p<0.01). Untargeted metabolomics were performed using tissue from the infarct zone (Metabolon Inc). Compared to IR, unloading preserved glycolytic activity, fatty acid oxidation, amino acid utilization and increased TCA cycle metabolites suggesting preserved mitochondrial function. To further explore the impact of unloading on mitochondrial function, we performed Seahorse analysis on mitochondria isolated from the infarct zone. Compared to sham controls, IR reduced function of mitochondrial complex I (CI), increased ROS levels, decreased ATP levels, and reduced mitochondrial membrane potential. In contrast, unloading preserved CI function and ATP levels while reducing ROS levels and maintaining membrane potential. Since ischemia alone converts CI from an activated to de-activated state, we next studied whether unloading limits ischemic injury without reperfusion. Adult swine (n=5-6/group) were subjected to 120 minutes of LAD occlusion followed by 120 minutes of occlusion with or without LV unloading. No reperfusion was performed. Compared to sham controls, ischemia increased deactivated CI levels and reduced CI activity. In contrast, unloading during ischemia reduced infarct size, reduced deactivated CI levels, and increased CI activity. We report for the first time that LV unloading limits myocardial injury, preserves energy substrate utilization, and protects mitochondrial function after ischemia injury with or without reperfusion.

Published
2019
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48. Duodenal Cannulation in Pigs ( Sus scrofa ) as a Drug Delivery Method.

Author

Beale CN, Reyelt LA, Bogins CA, Chan NY, and Perkins SE

Subjects
Animals, Catheterization adverse effects, Catheterization methods, Drug Administration Routes veterinary, Female, Vascular Access Devices adverse effects, Catheterization veterinary, Duodenum surgery, Sus scrofa, Vascular Access Devices veterinary
Abstract

Currently available animal models for delivery of drug capsules and pharmacokinetic testing are limited by either intersubject variability in gastric emptying time or the need to sedate animals when using targeted delivery methods of drug capsules. With the increasing development of large-molecule biologics, better in vivo models for testing the pharmacokinetics of capsule-delivered drugs are urgently needed. To this end, we made engineering modifications to an existing bovine surgical cannula device, successfully implanted this modified cannula into pigs, and delivered drug capsules directly to the proximal duodenum. In our porcine model, capsule insertion and serial blood samples were all acquired without the use of sedatives. Furthermore, we were able to maintain cannulated pigs for weekly pharmacokinetic testing for more than 18 mo, with minimal postoperative complications. This study demonstrates a novel and effective porcine model of sedation-free drug delivery and blood collection that eliminates inconsistencies associated with models that require either gastric emptying or animal sedation.

Published
2018

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