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1. Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

Author

Gentien, David, Saberi-Ansari, Elnaz, Servant, Nicolas, Jolly, Ariane, de la Grange, Pierre, Némati, Fariba, Liot, Géraldine, Saule, Simon, Teissandier, Aurélie, Bourc’his, Deborah, Girard, Elodie, Wong, Jennifer, Masliah-Planchon, Julien, Narmanli, Erkan, Liu, Yuanlong, Torun, Emma, Goulancourt, Rebecca, Rodrigues, Manuel, Gaudé, Laure Villoing, Reyes, Cécile, Bazire, Matéo, Chenegros, Thomas, Henry, Emilie, Rapinat, Audrey, Bohec, Mylene, Baulande, Sylvain, M’kacher, Radhia, Jeandidier, Eric, Nicolas, André, Ciriello, Giovanni, Margueron, Raphael, Decaudin, Didier, Cassoux, Nathalie, Piperno-Neumann, Sophie, Stern, Marc-Henri, Gibcus, Johan Harmen, Dekker, Job, Heard, Edith, Roman-Roman, Sergio, and Waterfall, Joshua J.

Published
2023
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4. Decentralization of Next-Generation RNA Sequencing-Based MammaPrint® and BluePrint® Kit at University Hospitals Leuven and Curie Institute Paris

Author

Slembrouck, Laurence, Darrigues, Lauren, Laurent, Cecile, Mittempergher, Lorenza, Delahaye, Leonie JMJ, Vanden Bempt, Isabelle, Vander Borght, Sara, Vliegen, Liesbet, Sintubin, Petra, Raynal, Virginie, Bohec, Mylene, Reyes, Cécile, Rapinat, Audrey, Helsmoortel, Céline, Jongen, Lynn, Hoste, Griet, Neven, Patrick, Wildiers, Hans, Smeets, Ann, Nevelsteen, Ines, Punie, Kevin, Van Nieuwenhuysen, Els, Han, Sileny, Vincent Salomon, Anne, Laas Faron, Enora, Cynober, Timothé, Gentien, David, Baulande, Sylvain, Snel, Mireille HJ, Witteveen, Anke T, Neijenhuis, Sari, Glas, Annuska M, Reyal, Fabien, and Floris, Giuseppe

Published
2019
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6. A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts

Author

Huet, Sarah, Tesson, Bruno, Jais, Jean-Philippe, Feldman, Andrew L, Magnano, Laura, Thomas, Emilie, Traverse-Glehen, Alexandra, Albaud, Benoit, Carrère, Marjorie, Xerri, Luc, Ansell, Stephen M, Baseggio, Lucile, Reyes, Cécile, Tarte, Karin, Boyault, Sandrine, Haioun, Corinne, Link, Brian K, Feugier, Pierre, Lopez-Guillermo, Armando, Tilly, Hervé, Brice, Pauline, Hayette, Sandrine, Jardin, Fabrice, Offner, Fritz, Sujobert, Pierre, Gentien, David, Viari, Alain, Campo, Elias, Cerhan, James R, and Salles, Gilles

Published
2018
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7. PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

Author

Montaudon, Elodie, Nikitorowicz-Buniak, Joanna, Sourd, Laura, Morisset, Ludivine, El Botty, Rania, Huguet, Léa, Dahmani, Ahmed, Painsec, Pierre, Nemati, Fariba, Vacher, Sophie, Chemlali, Walid, Masliah-Planchon, Julien, Château-Joubert, Sophie, Rega, Camilla, Leal, Mariana Ferreira, Simigdala, Nikiana, Pancholi, Sunil, Ribas, Ricardo, Nicolas, André, Meseure, Didier, Vincent-Salomon, Anne, Reyes, Cécile, Rapinat, Audrey, Gentien, David, Larcher, Thibaut, Bohec, Mylène, Baulande, Sylvain, Bernard, Virginie, Decaudin, Didier, Coussy, Florence, Le Romancer, Muriel, Dutertre, Guillaume, Tariq, Zakia, Cottu, Paul, Driouch, Keltouma, Bièche, Ivan, Martin, Lesley-Ann, and Marangoni, Elisabetta

Published
2020
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9. Supplemental Figure 4 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
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10. Supplemental Patient Information from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
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11. Supplemental Figure 3 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
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12. Supplemental Figure 5 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
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13. Supplemental Table 1 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
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14. Supplemental Figure 2 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
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15. Supplemental Table 2 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
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16. Supplementary Data from Establishment and Characterization of a Panel of Human Uveal Melanoma Xenografts Derived from Primary and/or Metastatic Tumors

Author

Némati, Fariba, primary, Sastre-Garau, Xavier, primary, Laurent, Cécile, primary, Couturier, Jérôme, primary, Mariani, Pascale, primary, Desjardins, Laurence, primary, Piperno-Neumann, Sophie, primary, Lantz, Olivier, primary, Asselain, Bernard, primary, Plancher, Corine, primary, Robert, Delphine, primary, Péguillet, Isabelle, primary, Donnadieu, Marie-Hélène, primary, Dahmani, Ahmed, primary, Bessard, Marie-Andrée, primary, Gentien, David, primary, Reyes, Cécile, primary, Saule, Simon, primary, Barillot, Emmanuel, primary, Roman-Roman, Sergio, primary, and Decaudin, Didier, primary

Published
2023
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17. Supplementary Video 2 from High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients

Author

Laurent, Cécile, primary, Valet, Fabien, primary, Planque, Nathalie, primary, Silveri, Licia, primary, Maacha, Selma, primary, Anezo, Océane, primary, Hupe, Philippe, primary, Plancher, Corine, primary, Reyes, Cécile, primary, Albaud, Benoit, primary, Rapinat, Audrey, primary, Gentien, David, primary, Couturier, Jérôme, primary, Sastre-Garau, Xavier, primary, Desjardins, Laurence, primary, Thiery, Jean-Paul, primary, Roman-Roman, Sergio, primary, Asselain, Bernard, primary, Barillot, Emmanuel, primary, Piperno-Neumann, Sophie, primary, and Saule, Simon, primary

Published
2023
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18. Supplementary Figure 1 from High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients

Author

Laurent, Cécile, primary, Valet, Fabien, primary, Planque, Nathalie, primary, Silveri, Licia, primary, Maacha, Selma, primary, Anezo, Océane, primary, Hupe, Philippe, primary, Plancher, Corine, primary, Reyes, Cécile, primary, Albaud, Benoit, primary, Rapinat, Audrey, primary, Gentien, David, primary, Couturier, Jérôme, primary, Sastre-Garau, Xavier, primary, Desjardins, Laurence, primary, Thiery, Jean-Paul, primary, Roman-Roman, Sergio, primary, Asselain, Bernard, primary, Barillot, Emmanuel, primary, Piperno-Neumann, Sophie, primary, and Saule, Simon, primary

Published
2023
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19. Supplementary Table 1 from High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients

Author

Laurent, Cécile, primary, Valet, Fabien, primary, Planque, Nathalie, primary, Silveri, Licia, primary, Maacha, Selma, primary, Anezo, Océane, primary, Hupe, Philippe, primary, Plancher, Corine, primary, Reyes, Cécile, primary, Albaud, Benoit, primary, Rapinat, Audrey, primary, Gentien, David, primary, Couturier, Jérôme, primary, Sastre-Garau, Xavier, primary, Desjardins, Laurence, primary, Thiery, Jean-Paul, primary, Roman-Roman, Sergio, primary, Asselain, Bernard, primary, Barillot, Emmanuel, primary, Piperno-Neumann, Sophie, primary, and Saule, Simon, primary

Published
2023
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20. Supplementary Video 3 from High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients

Author

Laurent, Cécile, primary, Valet, Fabien, primary, Planque, Nathalie, primary, Silveri, Licia, primary, Maacha, Selma, primary, Anezo, Océane, primary, Hupe, Philippe, primary, Plancher, Corine, primary, Reyes, Cécile, primary, Albaud, Benoit, primary, Rapinat, Audrey, primary, Gentien, David, primary, Couturier, Jérôme, primary, Sastre-Garau, Xavier, primary, Desjardins, Laurence, primary, Thiery, Jean-Paul, primary, Roman-Roman, Sergio, primary, Asselain, Bernard, primary, Barillot, Emmanuel, primary, Piperno-Neumann, Sophie, primary, and Saule, Simon, primary

Published
2023
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21. Supplementary Video 1 from High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients

Author

Laurent, Cécile, primary, Valet, Fabien, primary, Planque, Nathalie, primary, Silveri, Licia, primary, Maacha, Selma, primary, Anezo, Océane, primary, Hupe, Philippe, primary, Plancher, Corine, primary, Reyes, Cécile, primary, Albaud, Benoit, primary, Rapinat, Audrey, primary, Gentien, David, primary, Couturier, Jérôme, primary, Sastre-Garau, Xavier, primary, Desjardins, Laurence, primary, Thiery, Jean-Paul, primary, Roman-Roman, Sergio, primary, Asselain, Bernard, primary, Barillot, Emmanuel, primary, Piperno-Neumann, Sophie, primary, and Saule, Simon, primary

Published
2023
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24. PRMT1 Regulates EGFR and Wnt Signaling Pathways and Is a Promising Target for Combinatorial Treatment of Breast Cancer

Author

Suresh, Samyuktha, primary, Huard, Solène, additional, Brisson, Amélie, additional, Némati, Fariba, additional, Dakroub, Rayan, additional, Poulard, Coralie, additional, Ye, Mengliang, additional, Martel, Elise, additional, Reyes, Cécile, additional, Silvestre, David C., additional, Meseure, Didier, additional, Nicolas, André, additional, Gentien, David, additional, Fayyad-Kazan, Hussein, additional, Le Romancer, Muriel, additional, Decaudin, Didier, additional, Roman-Roman, Sergio, additional, and Dubois, Thierry, additional

Published
2022
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25. Multilayer spectrum of intratumoral heterogeneity in basal bladder cancer

Author

Sirab, Nanor, primary, Drubay, Damien, additional, Maillé, Pascale, additional, Popova, Tatiana, additional, Ngo, Carine, additional, Gentien, David, additional, Moktefi, Anissa, additional, Soyeux‐Porte, Pascale, additional, Pelletier, Romain, additional, Reyes, Cécile, additional, Henry, Emilie, additional, Pouessel, Damien, additional, Vordos, Dimitri, additional, Lebret, Thierry, additional, de Reyniès, Aurélien, additional, Paoletti, Xavier, additional, Radvanyi, François, additional, and Allory, Yves, additional

Published
2021
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26. PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer

Author

Suresh, Samyuktha, primary, Huard, Solène, additional, Brisson, Amélie, additional, Némati, Fariba, additional, Poulard, Coralie, additional, Ye, Mengliang, additional, Martel, Elise, additional, Reyes, Cécile, additional, Silvestre, David C., additional, Meseure, Didier, additional, Nicolas, André, additional, Gentien, David, additional, Le Romancer, Muriel, additional, Decaudin, Didier, additional, Roman-Roman, Sergio, additional, and Dubois, Thierry, additional

Published
2021
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27. Additional file 1 of HRAS is a therapeutic target in malignant chemo-resistant adenomyoepithelioma of the breast

Author

Bièche, Ivan, Coussy, Florence, El-Botty, Rania, Vacher, Sophie, Château-Joubert, Sophie, Dahmani, Ahmed, Montaudon, Elodie, Reyes, Cécile, Gentien, David, Reyal, Fabien, Ricci, Francesco, Nicolas, André, Marchio, Caterina, Vincent-Salomon, Anne, Laé, Marick, and Marangoni, Elisabetta

Abstract

Additional file 1. Material and Methods and References.

Published
2021
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28. G Protein–coupled Receptors in Radioiodine-refractory Thyroid Cancer in the Era of Precision Medicine

Author

Suteau, Valentine, primary, Seegers, Valérie, additional, Munier, Mathilde, additional, Ben Boubaker, Rym, additional, Reyes, Cécile, additional, Gentien, David, additional, Wery, Méline, additional, Croué, Anne, additional, Illouz, Frédéric, additional, Hamy, Antoine, additional, Rodien, Patrice, additional, and Briet, Claire, additional

Published
2021
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29. Multilayer spectrum of intratumoral heterogeneity in basal bladder cancer.

Author

Sirab, Nanor, Drubay, Damien, Maillé, Pascale, Popova, Tatiana, Ngo, Carine, Gentien, David, Moktefi, Anissa, Soyeux‐Porte, Pascale, Pelletier, Romain, Reyes, Cécile, Henry, Emilie, Pouessel, Damien, Vordos, Dimitri, Lebret, Thierry, de Reyniès, Aurélien, Paoletti, Xavier, Radvanyi, François, and Allory, Yves

Subjects
BLADDER cancer, HETEROGENEITY, CANCER invasiveness, NUCLEOTIDE sequencing, INDIVIDUALIZED medicine, ACCOUNTING methods
Abstract

Basal/squamous (Ba/Sq) subtype represents an intrinsic and robust group in the consensus molecular classification of muscle‐invasive bladder cancer (MIBC), with poor outcome and controversial chemosensitivity. We aimed to investigate the spectrum of intratumor heterogeneity (ITH) in the Ba/Sq subtype. First, we validated a 29‐gene NanoString CodeSet to predict the Ba/Sq subtype for FFPE samples. We identified heterogeneous Ba/Sq tumors in a series of 331 MIBC FFPE samples using dual GATA3/KRT5/6 immunohistochemistry (IHC). Heterogeneous regions with distinct immunostaining patterns were studied separately for gene expression using the 29‐gene CodeSet, for mutations by targeted next‐generation sequencing, and for copy number alteration (CNA) by microarray hybridization. Among 83 Ba/Sq tumors identified by GATA3/KRT5/6 dual staining, 19 tumors showed heterogeneity at the IHC level. In one third of the 19 cases, regions from the same tumor were classified in different distinct molecular subtypes. The mutational and CNA profiles confirmed the same clonal origin for IHC heterogeneous regions with possible subclonal evolution. Overall, two patterns of intratumoral heterogeneity (ITH) were observed in Ba/Sq tumors: low ITH (regions with distinct immunostaining, but common molecular subtype and shared CNA) or high ITH (regions with distinct immunostaining, molecular subtype, and CNA). These results showed multilayer heterogeneity in Ba/Sq MIBC. In view of personalized medicine, this heterogeneity adds complexity and should be taken into account for sampling procedures used for diagnosis and treatment choice. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2022
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30. BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

Author

Coussy, Florence, primary, El-Botty, Rania, additional, Château-Joubert, Sophie, additional, Dahmani, Ahmed, additional, Montaudon, Elodie, additional, Leboucher, Sophie, additional, Morisset, Ludivine, additional, Painsec, Pierre, additional, Sourd, Laura, additional, Huguet, Léa, additional, Nemati, Fariba, additional, Servely, Jean-Luc, additional, Larcher, Thibaut, additional, Vacher, Sophie, additional, Briaux, Adrien, additional, Reyes, Cécile, additional, La Rosa, Philippe, additional, Lucotte, Georges, additional, Popova, Tatiana, additional, Foidart, Pierre, additional, Sounni, Nor Eddine, additional, Noel, Agnès, additional, Decaudin, Didier, additional, Fuhrmann, Laetitia, additional, Salomon, Anne, additional, Reyal, Fabien, additional, Mueller, Christopher, additional, Ter Brugge, Petra, additional, Jonkers, Jos, additional, Poupon, Marie-France, additional, Stern, Marc-Henri, additional, Bièche, Ivan, additional, Pommier, Yves, additional, and Marangoni, Elisabetta, additional

Published
2020
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31. Specific Genomic Alterations in High-Grade Pulmonary Neuroendocrine Tumours with Carcinoid Morphology

Author

Cros, Jerôme, primary, Théou-Anton, Nathalie, additional, Gounant, Valérie, additional, Nicolle, Remy, additional, Reyes, Cécile, additional, Humez, Sarah, additional, Hescot, Ségolène, additional, Thomas de Montpréville, Vincent, additional, Guyétant, Serge, additional, Scoazec, Jean-Yves, additional, Guyard, Alice, additional, de Mestier, Louis, additional, Brosseau, Solenn, additional, Mordant, Pierre, additional, Castier, Yves, additional, Gentien, David, additional, Ruszniewski, Philippe, additional, Zalcman, Gérard, additional, Couvelard, Anne, additional, and Cazes, Aurélie, additional

Published
2020
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33. Specific Genomic Alterations in High-Grade Pulmonary Neuroendocrine Tumours with Carcinoid Morphology.

Author

Cros, Jerôme, Théou-Anton, Nathalie, Gounant, Valérie, Nicolle, Remy, Reyes, Cécile, Humez, Sarah, Hescot, Ségolène, Thomas de Montpréville, Vincent, Guyétant, Serge, Scoazec, Jean-Yves, Guyard, Alice, de Mestier, Louis, Brosseau, Solenn, Mordant, Pierre, Castier, Yves, Gentien, David, Ruszniewski, Philippe, Zalcman, Gérard, Couvelard, Anne, and Cazes, Aurélie

Subjects
CARCINOID, TUMORS, MORPHOLOGY, DNA repair, CELL adhesion, ONCOGENES
Abstract

Introduction: High-grade lung neuroendocrine tumours with carcinoid morphology have been recently reported; they may represent the thoracic counterparts of grade 3 digestive neuroendocrine tumours. We aimed to study their genetic landscape including analysis of tumoral heterogeneity. Methods: Eleven patients with high-grade (>20% Ki-67 and/or >10 mitoses) lung neuroendocrine tumours with a carcinoid morphology were included. We analysed copy number variations, somatic mutations, and protein expression in 16 tumour samples (2 samples were available for 5 patients allowing us to study spatial and temporal heterogeneity). Results: Genomic patterns were heterogeneous ranging from "quiet" to tetraploid, heavily rearranged genomes. Oncogene mutations were rare and most genetic alterations targeted tumour suppressor genes. Chromosomes 11 (7/11), 3 (6/11), 13 (4/11), and 6–17 (3/11) were the most frequently lost. Altered tumour suppressor genes were common to both carcinoids and neuroendocrine carcinomas, involving different pathways including chromatin remodelling (KMT2A, ARID1A, SETD2, SMARCA2, BAP1, PBRM1, KAT6A), DNA repair (MEN1, POLQ, ATR, MLH1, ATM), cell cycle (RB1, TP53, CDKN2A), cell adhesion (LATS2, CTNNB1, GSK3B) and metabolism (VHL). Comparative spatial/temporal analyses confirmed that these tumours emerged from clones of lower aggressivity but revealed that they were genetically heterogeneous accumulating "neuroendocrine carcinoma-like" genetic alterations through progression such as TP53/RB1 alterations. Conclusion: These data confirm the importance of chromatin remodelling genes in pulmonary carcinoids and highlight the potential role of TP53 and RB1 to drive the transformation in more aggressive high-grade tumours. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Abstract 2973: A comprehensive panel of patient-derived xenografts representing the molecular heterogeneity and diversity of triple-negative breast cancer

Author

Coussy, Florence, primary, Bernard, Virginie, additional, Lavigne, Marion, additional, Boulai, Anais, additional, Chateau-Joubert, Sophie, additional, Dahmani, Ahmed, additional, Montaudon, Elodie, additional, Reyes, Cécile, additional, Botty, Rania El, additional, Pieron, Gaëlle, additional, Laurent, Cécile, additional, Melaabi, Samia, additional, Salomon, Anne Vincent, additional, Bièche, Ivan, additional, and Marangoni, Elisabetta, additional

Published
2018
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35. Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, additional, Colmet Daage, Leo, additional, Richer, Wilfrid, additional, Gentien, David, additional, Pierron, Gaelle, additional, Lapouble, Eve, additional, Bellini, Angela, additional, Clement, Nathalie, additional, Iacono, Isabelle, additional, Bréjon, Stéphanie, additional, Carrere, Marjorie, additional, Reyes, Cécile, additional, Hocking, Toby, additional, Bernard, Virginie, additional, Peuchmaur, Michel, additional, Corradini, Nadège, additional, Faure-Conter, Cécile, additional, Coze, Carole, additional, Plantaz, Dominique, additional, Defachelles, Anne Sophie, additional, Thebaud, Estelle, additional, Gambart, Marion, additional, Millot, Frédéric, additional, Valteau-Couanet, Dominique, additional, Michon, Jean, additional, Puisieux, Alain, additional, Delattre, Olivier, additional, Combaret, Valérie, additional, and Schleiermacher, Gudrun, additional

Published
2016
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37. BRCA2Loss-of-Function and High Sensitivity to Cisplatin-Based Chemotherapy in a Patient With a Pleomorphic Soft Tissue Sarcoma: Effect of Genomic Medicine

Author

Tlemsani, Camille, Pasmant, Eric, Boudou-Rouquette, Pascaline, Bellesoeur, Audrey, Even, Julien, Larousserie, Frédérique, Reyes, Cécile, Gentien, David, Alexandre, Jérôme, Vidaud, Michel, Anract, Philippe, Leroy, Karen, and Goldwasser, François

Abstract

We report the case of a patient with a BRCA2germline mutation who developed a localized pleomorphic soft tissue sarcoma of the leg with poor prognostic features. BRCA2germline mutations were not previously reported to be associated with pleomorphic sarcoma. BRCA2loss-of-heterozygosity was found in the tumor, resulting in a complete BRCA2loss-of-function. BRCA2deficiency is associated with sensitivity to cisplatin-based chemotherapy in breast and ovarian cancer patients. We used a cisplatin-based chemotherapy. A rapid major partial response was obtained, which allowed a curative and conservative surgical resection of the sarcoma followed by adjuvant irradiation. This case illustrates that sarcoma patients may present unexpected but targetable genetic abnormalities and that BRCA2loss-of-function may be targetable in sarcoma as it is associated with enhanced sensitivity to cisplatin. Our observation emphasizes the input of genomic medicine in clinical practice, its importance for treatment decisions, and the overlap between constitutional and somatic genetics.

Published
2018
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38. High PTP4A3 Phosphatase Expression Correlates with Metastatic Risk in Uveal Melanoma Patients

Author

Laurent, Cécile, primary, Valet, Fabien, additional, Planque, Nathalie, additional, Silveri, Licia, additional, Maacha, Selma, additional, Anezo, Océane, additional, Hupe, Philippe, additional, Plancher, Corine, additional, Reyes, Cécile, additional, Albaud, Benoit, additional, Rapinat, Audrey, additional, Gentien, David, additional, Couturier, Jérôme, additional, Sastre-Garau, Xavier, additional, Desjardins, Laurence, additional, Thiery, Jean-Paul, additional, Roman-Roman, Sergio, additional, Asselain, Bernard, additional, Barillot, Emmanuel, additional, Piperno-Neumann, Sophie, additional, and Saule, Simon, additional

Published
2011
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39. Establishment and Characterization of a Panel of Human Uveal Melanoma Xenografts Derived from Primary and/or Metastatic Tumors

Author

Némati, Fariba, primary, Sastre-Garau, Xavier, additional, Laurent, Cécile, additional, Couturier, Jérôme, additional, Mariani, Pascale, additional, Desjardins, Laurence, additional, Piperno-Neumann, Sophie, additional, Lantz, Olivier, additional, Asselain, Bernard, additional, Plancher, Corine, additional, Robert, Delphine, additional, Péguillet, Isabelle, additional, Donnadieu, Marie-Hélène, additional, Dahmani, Ahmed, additional, Bessard, Marie-Andrée, additional, Gentien, David, additional, Reyes, Cécile, additional, Saule, Simon, additional, Barillot, Emmanuel, additional, Roman-Roman, Sergio, additional, and Decaudin, Didier, additional

Published
2010
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41. Non-invasive multi-cancer detection using DNA hypomethylation of LINE-1 retrotransposons.

Author

Michel M, Heidary M, Mechri A, Da Silva K, Gorse M, Dixon V, von Grafenstein K, Bianchi C, Hego C, Rampanou A, Lamy C, Kamal M, Le Tourneau C, Séné M, Bieche I, Reyes C, Gentien D, Stern MH, Lantz O, Cabel L, Pierga JY, Bidard FC, Azencott CA, and Proudhon C

Abstract

Purpose: The detection of circulating tumor DNA, which allows non-invasive tumor molecular profiling and disease follow-up, promises optimal and individualized management of patients with cancer. However, detecting small fractions of tumor DNA released when the tumor burden is reduced remains a challenge., Experimental Design: We implemented a new highly sensitive strategy to detect base-pair resolution methylation patterns from plasma DNA and assessed the potential of hypomethylation of LINE-1 retrotransposons as a non-invasive multi-cancer detection biomarker. The DIAMOND (Detection of Long Interspersed Nuclear Element Altered Methylation ON plasma DNA) method targets 30-40,000 young L1 scattered throughout the genome, covering about 100,000 CpG sites and is based on a reference-free analysis pipeline., Results: Resulting machine learning-based classifiers showed powerful correct classification rates discriminating healthy and tumor plasmas from 6 types of cancers (colorectal, breast, lung, ovarian, gastric cancers and uveal melanoma including localized stages) in two independent cohorts (AUC = 88% to 100%, N = 747). DIAMOND can also be used to perform copy number alterations (CNA) analysis which improves cancer detection., Conclusions: This should lead to the development of more efficient non-invasive diagnostic tests adapted to all cancer patients, based on the universality of these factors.

Published
2024
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