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1. Correction: Percutaneous hepatic melphalan perfusion: Single center experience of procedural characteristics, hemodynamic response, complications, and postoperative recovery.

Author

Manuel Florian Struck, Peter Kliem, Sebastian Ebel, Alice Bauer, Holger Gössmann, Rhea Veelken, Florian van Bömmel, Timm Denecke, Sebastian N Stehr, and Felix F Girrbach

Subjects
Medicine, Science
Abstract

[This corrects the article DOI: 10.1371/journal.pone.0254817.].

Published
2024
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2. Analysis of patient’s X-ray exposure in hepatic chemosaturation procedures: a single center experience

Author

Sebastian Ebel, Martin Reinhardt, Anne Bettina Beeskow, Felix Teske, Manuel Florian Struck, Rhea Veelken, Florian van Boemmel, Thomas Berg, Michael Moche, Matthias Gutberlet, Holger Gößmann, and Timm Denecke

Subjects
Percutaneous hepatic perfusion, Liver metastasis, Melanoma, Regional therapy, Inteventional radiology, Chemosaturation, Medical technology, R855-855.5
Abstract

Abstract Background Hepatic chemosaturation is a technique in which a high dose of the chemotherapeutic agent melphalan is administered directly into the liver while limiting systemic side effects. We reviewed our institutional experience regarding patient’s X-ray exposure caused by the procedure. Methods Fifty-five procedures, performed between 2016 and 2020 in 18 patients by three interventional radiologists (radiologist), were analyzed regarding the patient’s exposure to radiation. Dose-area-product (DAP) and fluoroscopy time (FT) were correlated with the experience of the radiologist and whether the preprocedural evaluation (CS-EVA) and the procedure were performed by the same radiologist. Additionally, the impact of previous liver surgery on DAP/FT was analyzed. Results Experienced radiologist require less DAP/FT (50 ± 18 Gy*cm2/13.2 ± 3.84 min vs. 69 ± 20 Gy*cm2/15.77 ± 7.82 min; p

Published
2022
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3. Predictive performance of newer Asian hepatocellular carcinoma risk scores in treated Caucasians with chronic hepatitis B

Author

George V. Papatheodoridis, George N. Dalekos, Ramazan Idilman, Vana Sypsa, Florian Van Boemmel, Maria Buti, Jose Luis Calleja, John Goulis, Spilios Manolakopoulos, Alessandro Loglio, Margarita Papatheodoridi, Nikolaos Gatselis, Rhea Veelken, Marta Lopez-Gomez, Bettina E. Hansen, Savvoula Savvidou, Anastasia Kourikou, John Vlachogiannakos, Kostas Galanis, Cihan Yurdaydin, Rafael Esteban, Harry L.A. Janssen, Thomas Berg, and Pietro Lampertico

Subjects
Cirrhosis, Entecavir, Tenofovir, Prediction, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background & Aims: Recently, several risk scores for prediction of hepatocellular carcinoma (HCC) were developed in cohorts of treated Asian patients with chronic hepatitis B (CHB), but they have not been assessed in non-Asian patients. We evaluated the predictability and comparative utility of our PAGE-B and recent Asian HCC risk scores in nucleos(t)ide analogue (NA)-treated adult Caucasian patients with CHB, with or without well-documented compensated cirrhosis but not previous diagnosis of HCC. Methods: We included 1,951 patients treated with entecavir/tenofovir and followed up for a median of 7.6 years. The c-statistic was used to estimate the predictability of PAGE-B, HCC-Rescue, CAMD, mPAGE-B, and AASL score for HCC development within 5 or 10 years. The low- and high-risk group cut-offs were used for estimation of negative (NPV) and positive predictive values (PPV), respectively. Results: HCC developed in 103/1,951 (5.3%) patients during the first 5 years and in another 39/1,428 (2.7%) patients between years 5 and 10. The 3-, 5-, and 10-year cumulative HCC rates were 3.3%, 5.9%, and 9.6%, respectively. All scores offered good 5- and 10-year HCC prediction (c-statistic: 0.78–0.82). NPVs were always >99% (99.3–100%), whereas PPV ranged between 13% and 24%. Conclusions: In NA-treated Caucasian patients with CHB including compensated cirrhosis, HCC risk scores developed in NA-treated Asian patients offer good 5- and 10-year HCC predictability, similar to that of PAGE-B. PAGE-B and mPAGE-B scores are simpler in clinical practice, as they do not require an accurate diagnosis of cirrhosis, but the addition of albumin in mPAGE-B score does not seem to offer an advantage in patients with well compensated liver disease. Lay summary: Several risk scores for prediction of hepatocellular carcinoma (HCC) were recently developed in cohorts of treated Asian patients with chronic hepatitis B (CHB). In Caucasian patients with CHB treated with oral antivirals, newer Asian HCC risk scores offer good 5- and 10-year HCC predictability, similar to that of PAGE-B. For clinical practice, PAGE-B and mPAGE-B scores are simpler, as they do not require an accurate diagnosis of cirrhosis.

Published
2021
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4. Percutaneous hepatic melphalan perfusion: Single center experience of procedural characteristics, hemodynamic response, complications, and postoperative recovery.

Author

Manuel Florian Struck, Peter Kliem, Sebastian Ebel, Alice Bauer, Holger Gössmann, Rhea Veelken, Florian van Bömmel, Timm Dennecke, Sebastian N Stehr, and Felix F Girrbach

Subjects
Medicine, Science
Abstract

BackgroundPercutaneous hepatic melphalan perfusion (PHMP) for the selective treatment of hepatic metastases is known to be associated with procedural hypotension and coagulation disorders. Studies on anesthetic management, perioperative course, complications, and postoperative recovery in the intensive care unit (ICU) have not been published.MethodsIn a retrospective observational study, we analyzed consecutive patients who were admitted for PHMP over a 6-year period (2016-2021). Analyses included demographic, treatment, and outcome data with regard to short-term complications until ICU discharge.ResultsFifty-three PHMP procedures of 16 patients were analyzed. In all of the cases, procedure-related hypotension required the median (range) highest noradrenaline infusion rate of 0.5 (0.17-2.1) μg kg min-1 and fluid resuscitation volume of 5 (3-14) liters. Eighty-four PHMP-related complications were observed in 33 cases (62%), of which 9 cases (27%) involved grade III and IV complications. Complications included airway constriction (requiring difficult airway management), vascular catheterization issues (which resulted in the premature termination of PHMP, as well as to the postponement of PHMP and to the performance of endovascular bleeding control after PHMP), and renal failure that required hemodialysis. Discharge from the ICU was possible after one day in most cases (n = 45; 85%); however, in 12 cases (23%), prolonged mechanical ventilation was required. There were no procedure-related fatalities.ConclusionsPHMP is frequently associated with challenging cardiovascular conditions and complications that require profound anesthetic skills. For safety reasons, PHMP should only be performed in specialized centers that provide high-level hospital infrastructures and interdisciplinary expertise.

Published
2021
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5. Repeated percutaneous hepatic perfusion with melphalan can maintain long-term response in patients with liver cancers

Author

Matus Rehak, Manuel F. Struck, Florian van Bömmel, Sebastian Ebel, B Maiwald, Thomas Berg, Tim-Ole Petersen, Steffen Strocka, Daniel Seehofer, D Forstmeyer, Sebastian Rademacher, Michael Moche, Timm Denecke, and Rhea Veelken

Subjects
Melphalan, musculoskeletal diseases, medicine.medical_specialty, Carcinoma, Hepatocellular, Short Communication, Gastroenterology, Percutaneous hepatic perfusion, Stable Disease, Uveal melanoma, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, natural sciences, Adverse effect, Antineoplastic Agents, Alkylating, Retrospective Studies, business.industry, Liver Neoplasms, Middle Aged, medicine.disease, Perfusion, Bile Ducts, Intrahepatic, Tolerability, Chemosaturation, Bile Duct Neoplasms, Hepatocellular carcinoma, Chemotherapy, Cancer, Regional Perfusion, Liver function, Cardiology and Cardiovascular Medicine, business, Liver cancer, medicine.drug
Abstract

Chemosaturation (CS; CHEMOSAT®, Delcath Systems Inc.) temporarily administers melphalan into the liver by percutaneous hepatic perfusion (PHP). CS-PHP can effectively control growth in liver tumors, but efficacy and tolerability of sequential treatments are unclear. We analyzed outcomes of sequential CS-PHP treatment. Patients with either unresectable intrahepatic metastases of ocular melanoma (OM, n = 9), cholangiocarcinoma (CCA, n = 3), or hepatocellular carcinoma (HCC, n = 1) were recruited retrospectively. Response was assessed by tomography imaging. Ten patients (mean age 60 years) with more than one CS-PHP treatment were included. CS-PHP was administered 2–6 times in the OM patients, 3 times in the CCA, and the HCC patient received 6 treatments. Overall response rate (ORR) to CS-PHP was 80%, and stable disease was achieved in one patient. Median hepatic progression-free survival (hPFS) was 336 days (range 0–354) for OM, 251 days for the CCA patient, and 256 days for the HCC patient. At the end of observation (153–701 days after first CS-PHP), 6/10 patients were still alive (5/9 with OM, 0 with CCA, and 1 with HCC). Death cases were not related to CS-PHP. Adverse events were mostly hematologic, grade I-IV, and self-resolving. The liver function was not deteriorated by CS-PHP. We conclude that repeated CS-PHP treatments were effective and well tolerated in the long term.

Published
2021

7. The Liver Maximum Capacity Test (LiMAx) Is Associated with Short-Term Survival in Patients with Early Stage HCC Undergoing Transarterial Treatment

Author

Janett Fischer, Stella Wellhöner, Sebastian Ebel, Thomas Lincke, Albrecht Böhlig, Florian Gerhardt, Rhea Veelken, Holger Goessmann, Karen Geva Steinhoff, Timm Denecke, Osama Sabri, Thomas Berg, and Florian van Bömmel

Subjects
Cancer Research, Oncology, TACE, TARE, liver function, adverse events, survival
Abstract

Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are recommended to treat patients with early or intermediate hepatocellular carcinoma (HCC). The liver maximum capacity test (LiMAx) has been supposed to predict the risk of post-interventional liver failure. We investigated the correlation of LiMAx with short-term survival as primary endpoint and the occurrence of adverse events after therapy as secondary endpoint. Our study cohort prospectively included 69 patients receiving TACE (n = 57) or TARE (n = 12). LiMAx test and serological analyses were performed on the day before and 4 weeks after treatment. Hepatic and extrahepatic complications were monitored for 4 weeks. The LiMAx results were not associated with altered liver function and the occurrence of adverse events. The survival rates of patients with BCLC A with LiMAx ≤ 150 μg/kg/h were lower after 30 days (75.0 ± 15.3% vs. 100%, p = 0.011), 90 days (62.5 ± 17.7% vs. 95.8 ± 4.1%, p = 0.011) and 180 days (50.0 ± 17.7% vs. 95.8 ± 4.1%, p = 0.001) compared to those with higher LiMAx levels. The LiMAx test is not suitable to predict liver function abnormalities or the occurrence of complications 4 weeks after therapy but enables the identification of patients with early stage HCC and reduced short-term survival after treatment.

Published
2022
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8. Diagnostik und Therapie des hepatozellulären Karzinoms

Author

Rhea Veelken, Daniel Seehofer, Thomas Berg, Florian van Bömmel, Timm Denecke, and Aaron Schindler

Subjects
0301 basic medicine, Gynecology, 03 medical and health sciences, medicine.medical_specialty, 030104 developmental biology, 0302 clinical medicine, Oncology, business.industry, 030220 oncology & carcinogenesis, Medicine, Hematology, business
Abstract

Die Inzidenz des hepatozellularen Karzinoms (HCC) steigt seit einigen Jahren weltweit. Die Grundlage fur die HCC-Entwicklung ist meist eine Leberzirrhose verschiedener Ursache. Ultraschalluntersuchungen zur Fruherkennung sollen bei allen Patienten mit erhohtem HCC-Risiko alle 6 Monate durchgefuhrt werden. Hepatische Raumforderung von >1 cm Grose sollen mittels kontrastverstarkter Schnittbildgebung weiter abgeklart werden. Ein charakteristisches Kontrastmittelverhalten der Lasion ist bei Zirrhose beweisend fur das Vorliegen eines HCC. In unklaren Situationen erfolgt die Diagnosestellung histologisch. HCCs erfordern ein interdisziplinares Vorgehen. Alle Patienten mit HCC sollten an einem Schwerpunktzentrum vorgestellt werden, um mogliche kurative Ansatze zu erwagen. Die palliative Behandlung schliest im intermediaren Stadium lokoregionare und im fortgeschrittenen Stadium systemische Behandlungen (seit kurzem auch Kombinationstherapien mit Immuncheckpointinhibitoren) ein.

Published
2020
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12. Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B

Author

Florian van Boemmel, Maria Buti, Spilios Manolakopoulos, Thomas Berg, Pietro Lampertico, Vana Sypsa, Bettina E. Hansen, Alessandro Loglio, Savvoula Savvidou, Kostas Galanis, John Goulis, Cihan Yurdaydin, Rhea Veelken, Nikolaos K. Gatselis, Anastasia Kourikou, Jose Luis Calleja, Rafael Esteban, Marta López-Gómez, John Vlachogiannakos, Ramazan Idilman, George N Dalekos, Harry L.A. Janssen, Margarita Papatheodoridi, George V. Papatheodoridis, and Gastroenterology & Hepatology

Subjects
0301 basic medicine, HBsAg, medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Proportional hazards model, Incidence (epidemiology), medicine.medical_treatment, Entecavir, Liver transplantation, medicine.disease, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, Hepatocellular carcinoma, Medicine, 030211 gastroenterology & hepatology, business, Liver cancer, medicine.drug
Abstract

Background & Aims The incidence of hepatocellular carcinoma (HCC) was recently reported to be lower in Asian chronic hepatitis B (CHB) patients treated with tenofovir disoproxil fumarate (TDF) than entecavir (ETV), but this finding remains controversial. We assessed whether there was a difference between ETV and TDF treated patients of the well monitored, multicenter European PAGE-B cohort in the HCC incidence and other patient outcomes. Methods We included 1935 Caucasians with CHB, with or without compensated cirrhosis, treated with ETV (n=772) or TDF (n=1163) monotherapy. Mean follow-up has been 7.1±3.0 years from ETV/TDF onset. Results The 5-year cumulative HCC incidence was 5.4% in ETV and 6.0% in TDF treated patients (log-rank, P=0.321) without significant difference in any patient subgroup [with or without cirrhosis, naive or experienced to oral antiviral(s) (total, with or without cirrhosis)]. In multivariable Cox regression analyses, the hazard of HCC was similar between ETV and TDF treated patients after adjustment for several HCC risk factors. ETV and TDF treated patients had similar rates of on-therapy biochemical and virological remission, HBsAg loss, liver transplantation and/or death. Elastographic reversion of cirrhosis at year 5 (liver stiffness Conclusion In Caucasian CHB patients, with or without cirrhosis, ETV and TDF long-term monotherapy is associated with similar HCC risk and rates of biochemical and virological remission, HBsAg loss and liver transplantation or death, but TDF seems to result in more frequent elastographic reversion of cirrhosis at year 5.

Published
2020
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14. Chronisch-entzündliche Darmerkrankungen (CED)

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Subjects
business.industry, Medicine, business
Published
2021
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15. Dünndarm

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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16. Infektiöse Darmerkrankungen

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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17. Magen und Duodenum

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Subjects
business.industry, Medicine, business
Published
2021
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18. Diagnostische und therapeutische Verfahren

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Subjects
business.industry, Medicine, business
Published
2021
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19. Proktologische Erkrankungen

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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20. Pankreas

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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21. Besondere Störungen

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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22. Gastroenterologische Notfälle und Leitsymptome

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Subjects
business.industry, Medicine, business
Published
2021
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23. Risikomanagement in der Gastroenterologie

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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24. Kolon

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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25. Ösophagus

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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26. Leber

Author

Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, and Kathrin Zimmermann

Published
2021
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32. Polysialic acid interacts with lactoferrin and supports its activity to inhibit the release of neutrophil extracellular traps

Author

Silvia Rudloff, Andrea Kühnle, Hans-Christian Schuppe, Clemens Kunz, Christina E. Galuska, Rhea Veelken, Sebastian P. Galuska, Max Saftenberger, and Marieke Verleih

Subjects
Innate immune system, Polymers and Plastics, biology, Lactoferrin, Polysialic acid, Organic Chemistry, food and beverages, 02 engineering and technology, Neutrophil extracellular traps, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Sialic acid, stomatognathic diseases, chemistry.chemical_compound, fluids and secretions, chemistry, Biochemistry, Lactoferricin, Materials Chemistry, biology.protein, Antibody, 0210 nano-technology, Function (biology)
Abstract

Polysialic acid (polySia) is a linear carbohydrate polymer consisting of N-acetylneuraminic acid residues and is involved in several physiological processes. In the present study, we identified the multifunctional protein lactoferrin as a novel interaction partner for polySia. Lactoferrin co-precipitated when polySia was isolated from human blood, milk, and semen samples. The interaction between polySia and lactoferrin was verified using a native gel electrophoresis application, demonstrating that such interaction depends on the degree of polymerization. The interaction between the molecules could be inhibited by an antibody against lactoferricin (LFcin), which suggests that the LFcin domain of lactoferrin represents the potential binding area for sialic acid polymers. Because lactoferrin inhibits the formation of neutrophil extracellular traps (NETs), the potential impact of polySia on this function of lactoferrin was tested. Intriguingly, we observed that polySia increases the efficiency of lactoferrin to prevent the release of NET fibers. PolySia alone shows no activity. Therefore, together with lactoferrin, polySia may represent a natural regulatory system of NET release.

Published
2018

33. FRI-197-Prediction of elastographic reversion of cirrhosis after 5 years of entecavir or tenofovir disoproxil fumarate therapy in caucasian chronic hepatitis B patients

Author

Spilios Manolakopoulos, Harry L.A. Janssen, Vana Sypsa, George N. Dalekos, George V. Papatheodoridis, Anastasia Kourikou, Heng Chi, Thomas Berg, Kostas Galanis, Pietro Lampertico, Ioannis Vlachogiannakos, Rafael Esteban, Savvoula Savvidou, Marta López-Gómez, Rhea Veelken, Theodoros Voulgaris, Florian van Bömmel, Bettina E. Hansen, Onur Keskin, Ioannis Goulis, Nikolaos K. Gatselis, José Luis Calleja Panero, Cihan Yurdaydin, Maria Buti, Ramazan Idilman, and Alessandro Loglio

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, Tenofovir, business.industry, Reversion, Entecavir, medicine.disease, Gastroenterology, Chronic hepatitis, Internal medicine, medicine, business, medicine.drug
Published
2019
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34. SAT-491-Assessment of liver function by 13C methacetin breath test may help to predict liver function deterioration after selective transarterial chemoembolisation of hepatocellular carcinomas

Author

Albrecht Boehlig, Thomas Berg, Tim-Ole Petersen, B Maiwald, Rhea Veelken, Florian Gerhardt, Steffen Strocka, Florian van Bömmel, and Stella Wellhöner

Subjects
Breath test, medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Internal medicine, medicine, Liver function, business, Gastroenterology
Published
2019
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