Search

Objective: To examine the relation between the serum levels of tumour necrosis factor α (TNFα), soluble tumour necrosis factor receptors (sTNF-R), and the histological pattern of rheumatoid synovitis. Methods: An [...]

Objectives: To investigate whether anti-Saccharomyces cerevisiae antibodies (ASCA), a marker for Crohn's disease (CD), are present in spondyloarthropathies (SPA) and in the subgroups ankylosing spondylitis (AS), undifferentiated SpA (uSpA), and [...]

Objective: To evaluate whether, in patients with the diffuse form of systemic sclerosis (dSSc), macrophage migration inhibitory factor (MIF) production is dysregulated. Methods: 10 patients with dSSc and 10 healthy [...]

Background: Anti-chromatin antibodies have recently been described in patients with systemic lupus erythematosus (SLE) and it has been suggested that their presence is associated with lupus nephritis. Objective: To assess [...]

Objective: To evaluate a contribution of selected laboratory parameters for a prediction of progressive and erosive development in patients with early rheumatoid arthritis (RA). Methods: In a prospective study baseline [...]

Many infections have been found to be associated with antiphospholipid antibodies (aPL), although a pathogenic role for these antibodies has not usually been obvious except in a few isolated cases. [...]

General practice patients in Queeensland diagnosed with Ross River virus (RRV) disease were evaluated to determine the natural history of rheumatic manifestations of RRV. Outcomes from the study show that the duration and prevalence of symptoms in RRV were previously overestimated and that a 3-6 month progressive resolution is normal.

The rheumatic diseases continue to represent a significant healthcare burden in the 21st century. However, despite the best standard of care and recent therapeutic advances it is still not possible [...]

Studies conducted over the past decade have demonstrated a central role for tumour necrosis factor α (TNFα) in inflammatory diseases. As a result of this work, a number of biological [...]

Interplay between innate and adaptive immunity Intracellular pathogens live inside host cells, and survival is dependent on coexistence with the host. In their intracellular niche these pathogens are well shielded [...]

Background--Mammalian Toll-like receptor (TLR) proteins are pattern recognition receptors for a diverse array of bacterial and viral products. Gram negative bacterial lipopolysaccharide (LPS) activates cells through TLR4, whereas the mycobacterial [...]

Behcet's disease (BD) is a multisystemic disorder with mucocutaneous, ocular, arthritic, vascular, and central nervous system involvements. (1) Recent developments in the immunopathogenesis of BD are discussed in this review. [...]

The atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, is a cardiovascular hormone which possesses well defined natriuretic, diuretic, and vasodilating properties. Most of the biological effects [...]

Swedish researchers at the KAROLINSKA INSTITUTE found that of the 32,000-plus women they followed for nearly eight years, those who ate fish at least once a week were 29% less [...]

Research findings, 'Serum procalcitonin in systemic autoimmune diseases--where are we now,' are discussed in a new report. In this recent report, researchers in the United States conducted a study 'To [...]

Scientists discuss in 'Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and a-enolase: implications for autoimmunity in rheumatoid arthritis' new findings in arthritis. According to recent research published in the [...]

Scientists discuss in 'Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen [...]

According to recent research published in the journal Arthritis & Rheumatism - Arthritis Care & Research, 'Wegener's granulomatosis (WG) is a systemic vasculitis of unknown etiology. The UK General Practice [...]

In this recent report published in the journal Arthritis and Rheumatism, researchers in Beijing, People's Republic of China conducted a study "To determine the possible involvement and regulatory mechanisms of [...]

In this recent report published in the journal Arthritis and Rheumatism, researchers in Leeds, the United Kingdom conducted a study "To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, [...]

'It has been suggested that anticitrullinated protein antibodies (ACPAs) play an important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic effects, ACPAs must recruit immune effector [...]

"Interferon regulatory factor 5 is a transcription factor involved in type I interferon (IFN) secretion. This study was undertaken to investigate whether a 5-bp (CGGGG insertion/deletion) promoter polymorphism is involved [...]

In this recent report, researchers in Huddinge, Sweden conducted a study 'To examine whether there is an association between country of birth in first-generation immigrants and first hospitalization for a [...]

In this recently published article, scientists in the United States conducted a study 'To determine the incidence of self-reported depression (SRD) in rheumatoid arthritis and to identify and rank clinically [...]

According to recent research from Stockholm, Sweden, "Human cytomegalovirius (HCMV) is frequently detected in autoimmune diseases, but its role in such disorders is poorly understood. Herein we describe the case [...]

Researchers in the United States conducted a study 'To assess physicians' concordance with Disease Activity Score in 28 joints (DAS28) categories calculated by an electronic medical record (EMR)-embedded disease activity [...]

According to recent research published in the journal Arthritis and Rheumatism, 'The microanatomic basis for formation of erosions in inflammatory arthritis is incompletely understood but is thought to be related [...]

According to recent research from Helsinki, Finland, "Sjogren's syndrome (SS) is characterized by atrophy and malfunction of the acinar cells. The aim of this study was to investigate whether type [...]

In this recent study, researchers in Montreal, Canada conducted a study "To assess whether the risk of incident systemic lupus erythematosus (SLE) is associated with the use of combined oral [...]

In this recent study, researchers in the United States conducted a study 'To explore, using recent data, whether and how risk factors for rheumatoid arthritis (RA) work disability may differ [...]

According to recent research published in the journal Brain and Language, 'Verbs contain multifaceted information about both the semantics of an action, and potential argument structures. Linguistic theory classifies verbs [...]

'Chronic disease affects both patients and spouses, yet the effect of vasculitis on the spouses of patients has not been systematically examined. We addressed this research gap by describing 8 [...]

In this recent study, researchers in Oxford, the United Kingdom conducted a study 'To develop European League Against Rheumatism (EULAR) recommendations for the management of small and medium vessel vasculitis. [...]

In this recent study, researchers in Montreal, Canada conducted a study "To determine whether sex plays a role in the time to diagnosis of systemic sclerosis (SSc). In the Canadian [...]

According to recent research from the United States, "The serum C-reactive protein (CRP) concentration is commonly used in rheumatoid arthritis (RA) as a surrogate marker of systemic inflammation, presumably induced [...]

Scientists discuss in 'High-sensitivity C-reactive protein as an associate of clinical subsets and organ damage in systemic lupus erythematosus' new findings in lupus. According to recent research from the United [...]