587 results on '"Rheumatoid vasculitis"'
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2. Rheumatoid meningitis: a case series report and review of modern therapeutic schemes and outcome
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Serra Smith, Carlos, Montero Reyes, Fernando José, Contreras Chicote, Ana, Martínez Barrio, Julia, Vieru, Mihaela, Herrera Herrera, Isabel, Arias, Francisco, Martínez Ginés, Marisa, and García Domínguez, Jose Manuel
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- 2024
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3. Successful peficitinib monotherapy for the new-onset skin manifestations of rheumatoid vasculitis after long-term treatment with tocilizumab for rheumatoid arthritis.
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Oba, Yuki, Sawa, Naoki, Ikuma, Daisuke, Mizuno, Hiroki, Inoue, Noriko, Sekine, Akinari, Hasegawa, Eiko, Yamanouchi, Masayuki, Suwabe, Tatsuya, Yamaguchi, Yuko, Takasawa, Yutaka, and Ubara, Yoshifumi
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CUTANEOUS manifestations of general diseases , *LEUKOCYTOCLASTIC vasculitis , *RHEUMATOID arthritis , *VASCULITIS , *SKIN ulcers , *STAT proteins , *TOCILIZUMAB - Published
- 2024
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4. Effectiveness and safety of rituximab in special types of rheumatoid arthritis.
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Takanashi, Satoshi, Kondo, Yasushi, Saito, Shuntaro, Kikuchi, Jun, Hanaoka, Hironari, Takeuchi, Tsutomu, and Kaneko, Yuko
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RHEUMATOID arthritis , *RITUXIMAB , *LYMPHOPROLIFERATIVE disorders , *SKIN ulcers , *DISEASE progression , *LEUKOCYTOCLASTIC vasculitis - Abstract
Objectives: To elucidate the efficacy and safety of rituximab in special types of rheumatoid arthritis. Methods: We retrospectively reviewed all patients with rheumatoid arthritis with lymphoproliferative disorder or vasculitis treated with rituximab between April 2010 and June 2022 at Keio University Hospital. We assessed the effectiveness of rituximab using the Disease Activity Score for 28 joints‐erythrocyte sedimentation rate (DAS28‐ESR), Clinical Disease Activity Index (CDAI), and safety of rituximab during the disease course. We also assessed the glucocorticoid‐sparing effects of rituximab. Results: We included eight patients with a history of lymphoproliferative disorder and five patients with rheumatoid vasculitis. They were treated with rituximab without high‐dose glucocorticoid. The mean DAS28‐ESR and CDAI scores significantly improved 12 months after rituximab administration (DAS28‐ESR, 4.7 vs. 2.7, p <.001; CDAI, 16.0 vs. 5.1, p =.006, respectively), and the dose of prednisolone was reduced from a mean of 7.4 mg/day to 4.0 mg/day at 12 months (p =.05) and 3.2 mg/day at the last visit (p =.04). During the mean follow‐up period of 52 months, we recorded one recurrence of lymphoproliferative disorder (not B‐cell type) in patients with a history of lymphoproliferative disorder and remarkable improvement of skin ulcers in patients with vasculitis. Conclusion: B‐cell depletion by rituximab may be a useful treatment option for patients with lymphoproliferative disorder and rheumatoid vasculitis. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Rheumatoid Vasculitis
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Makol, Ashima, Kermani, Tanaz, Warrington, Kenneth, Stone, John H., Matteson, Eric L., and Stone, John H., editor
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- 2023
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6. A Neurological Complication in Rheumatoid Arthritis -- A Scenario of Catastrophic Proportions.
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Varshney, Megha, Ray, Sucharita, Reddy, Manod, Chatterjee, Debajyoti, Chakravarty, Kamalesh, Bhatia, Vikas, and Lal, Vivek
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CEREBRAL small vessel diseases , *X-rays , *NEUROLOGICAL disorders , *CRANIAL nerve diseases , *PERIPHERAL neuropathy , *CEREBRAL hemorrhage , *MAGNETIC resonance imaging , *SEVERITY of illness index , *CATASTROPHIC illness , *RHEUMATOID arthritis , *BLOOD testing , *VASCULITIS , *DISEASE complications , *SYMPTOMS - Abstract
Background: Rheumatoid Arthritis (RA) is a common systemic inflammatory disease that can present with a plethora of extraarticular manifestations. Many patients with RA from low and middle income countries do not get timely and adequate treatment with disease modifying therapies. This results in the perpetuation of a chronic inflammatory state. Focus: Rheumatoid vasculitis (RV) is one of the most aggressive complications of RA resulting from a prolonged proinflammatory milieu. Usually, it has the involvement of multiple organ systems, with cutaneous manifestations being the most common. Neurological presentation is uncommon but severe when present. Highlight: We present a case of severe RV presenting with an unexpected neurological complication consisting of cranial and peripheral neuropathy with small vessel disease and intracerebral haemorrhage. We intend to highlight the morbidity and long term consequences of inadequately treated RA, the most common inflammatory disease of the connective system especially in light of the neurological presentation. [ABSTRACT FROM AUTHOR]
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- 2023
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7. A Neurological Complication in Rheumatoid Arthritis – A Scenario of Catastrophic Proportions
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Megha Varshney, Sucharita Ray, Manod Reddy, Debajyoti Chatterjee, Kamalesh Chakravarty, Vikas Bhatia, and Vivek Lal
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axonopathy ,motor neuron ,motor neuropathy ,neuronopathy ,rheumatoid arthritis ,rheumatoid vasculitis ,vasculitis ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Rheumatoid Arthritis (RA) is a common systemic inflammatory disease that can present with a plethora of extraarticular manifestations. Many patients with RA from low- and middle-income countries do not get timely and adequate treatment with disease-modifying therapies. This results in the perpetuation of a chronic inflammatory state. Focus: Rheumatoid vasculitis (RV) is one of the most aggressive complications of RA resulting from a prolonged proinflammatory milieu. Usually, it has the involvement of multiple organ systems, with cutaneous manifestations being the most common. Neurological presentation is uncommon but severe when present. Highlight: We present a case of severe RV presenting with an unexpected neurological complication consisting of cranial and peripheral neuropathy with small vessel disease and intracerebral haemorrhage. We intend to highlight the morbidity and long-term consequences of inadequately treated RA, the most common inflammatory disease of the connective system especially in light of the neurological presentation.
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- 2023
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8. A case of central nervous system vasculitis secondary to rheumatoid arthritis treated successfully with mycophenolate.
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Das, Shyamashis, Sinha, Debanjali, Ghosal, Anirban, and Purkayastha, Sukalyan
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CENTRAL nervous system , *RHEUMATOID arthritis , *VASCULITIS , *MYCOPHENOLIC acid , *TREATMENT effectiveness , *VIRAL encephalitis - Published
- 2023
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9. Pathophysiology and clinical manifestations of immune complex vasculitides
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Cord Sunderkötter, Linda Golle, Evangéline Pillebout, and Christiane Michl
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IgA vasculitis ,cryoglobulinemic vasculitis ,rheumatoid vasculitis ,hypocomplementaemic vasculitis ,serum sickness ,glomerulonephritis IgA1 ,Medicine (General) ,R5-920 - Abstract
Immune complex (IC) vasculitides present inflammations of vessel walls associated with perivascular deposition of immunoglobulins (Igs), mostly ICs. They encompass systemic and skin-limited variants of IgA vasculitis (IgAV), cryoglobulinemic vasculitis (CV), rheumatoid, lupus, and hypocomplementemic vasculitides, serum sickness cutaneous IgM/IgG (non-IgA) vasculitis, and recurrent macular (hypergammaglobulinemic or exertion-induced) vasculitis. Serum sickness and CV fulfill the criteria of a type III hypersensitivity immune reaction as large lattices of the IC precipitate at vessel walls and activate polymorphonuclear neutrophils (PMNs). Immunoglobulin-A vasculitis differs with regard to the causes of perivascular deposition of ICs since here many IgA1 molecules are hypoglycosylated (Gd-IgA1), which appears to facilitate their perivascular deposition in skin and mesangium (via e.g. CD71). The reasons for increased generation of immunoglobulins or formation of IC and their perivascular deposition in either skin or systemic organs are different and not fully explored. A common denominator of OC vasculitides is the activation of PMNs near the vessel wall via Fcy or Fcα receptors. Acute episodes of IgAV additionally require PMNs to become preactivated by IgA1 or by IC already in circulation. This intravascular priming results in increased adherence and subsequently vessel-destructive NETosis when they encounter IgA deposited at the vessel walls. Binding of IgA1 to PMNs in blood stream is associated with increased serum levels of hypogalactosidated IgA1. The characteristic clinical picture of IgAV (and also of so-called IgG/IgM vasculitis) comprises palpable or retiform purpura with a clear predilection for lower legs, probably due to stasis-related reduction in blood velocity, while in other IC vasculitides, additional factors influence the sites of vasculitides. Our knowledge of distinct forms and different pathophysiological pathways of IC vasculitides may lead to in efficacious or targeted therapies. Antibodies to complement components or intestinal budesonide for IgAV are promising agents (the latter suppresses the pathophysiologically related IgA nephropathy by reducing the generation of mucosal IgA.
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- 2023
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10. További szisztémás vasculitisek.
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NÓRA, LEGÁNY, ATTILA, BALOG, and LÁSZLÓ, KOVÁCS
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Copyright of Immunology Quaterly / Immunológia Szemle is the property of Medicina Konyvkiado Zrt. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
11. Peripheral ulcerative keratitis, nodular episcleritis, and pulmonary nodules as the initial signs of rheumatic arthritis: A Case Report.
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Jingting Wang, Qin Zhang, Weiyun Shi, Yilin Pang, and Suxia Li
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PULMONARY nodules ,CORNEAL ulcer ,SCLERITIS ,RHEUMATOID factor ,RHEUMATOID arthritis - Abstract
Background: Rheumatoid vasculitis (RV) is a rare but potentially devastating complication of rheumatoid arthritis (RA). It typically occurs in patients with extra-articular manifestations. Here we reported a case of PUK with nodular episcleritis and pulmonary nodules that occurred in the same patient without joint involvement. Case presentation: A 43-year-old Chinese woman, exhibited a partial crescent-shaped marginal corneal ulcer in the right eye at admission and the ulcer developed rapidly into nearly 360-degree ulcers in both eyes within one week. Nodular episcleritis was observed in the right eye. Conjunctival biopsy revealed vasculitis. Her rheumatoid factor (RF) and anti-cyclic citrullinated protein antibody were positive, while anti-neutrophilic cytoplasmic antibody (c-ANCA) and anti-protease 3 were negative. Pulmonary nodules were found, without joint involvement. The ocular condition did not relieve under the topical and systemic use of corticosteroids, or under other immunosuppressive agents until the infliximab therapy. PUK recurrence was observed after the discontinuation of infliximab. Conclusions: Rapidly deteriorated PUK with nodular episcleritis and pulmonary nodules occurred in the same patient is a special case of RA without joint involvement. This case reinforces the concept that RV may be the initial sign of RA. Infliximab can be used to prevent further progress of RA-related PUK in some refractory cases. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Inflammatory Arthritides
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Moutsopoulos, Haralampos M., Zampeli, Evangelia, Moutsopoulos, Haralampos M., editor, and Zampeli, Evangelia, editor
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- 2021
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13. Spinal subarachnoid haemorrhage secondary to spinal rheumatoid vasculitis: a case report
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Yeqing Xiao, Jie Yang, Jian Xia, Yunhai Liu, Qing Huang, and Jie Feng
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Case report ,Spinal vasculitis ,Rheumatoid arthritis ,Rheumatoid vasculitis ,Spinal subarachnoid haemorrhage ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Introduction Spinal subarachnoid haemorrhage is extremely rare in cases of subarachnoid haemorrhage and possesses servere characteristics. Additionally, spinal rheumatoid vasculitis is rare for spinal subarachnoid haemorrhage. The pathogenesis is unknown. Case presentation A 52-year-old woman with a 10-year history of seropositive rheumatoid arthritis was managed with leflunomide and celecoxib, and stable low disease activity was achieved. The patient had also been diagnosed with spinal subarachnoid haemorrhage secondary to isolated spinal rheumatoid vasculitis and obtained good therapeutic effects. Conclusion This is the first case to describe spinal subarachnoid haemorrhage secondary to isolated spinal vasculitis in a patient with rheumatoid arthritis, which provides more proof of anomalous neovascularization in the central nervous system in rheumatoid arthritis.
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- 2021
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14. Demyelinating neuropathy requires differential diagnosis with vasculitic neuropathy in rheumatoid arthritis: Significance of sural nerve electrophysiology findings.
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Kobayashi, Masaki, Takeuchi, Megumi, Suzuki, Miki, and Kitagawa, Kazuo
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RHEUMATOID arthritis , *ACTION potentials , *NEUROPATHY , *DIFFERENTIAL diagnosis , *ELECTROPHYSIOLOGY , *ENTRAPMENT neuropathies , *POLYARTERITIS nodosa - Abstract
Objectives: Neuropathy is considered a complication of rheumatoid arthritis (RA), whose underlying mechanisms are mainly entrapment, drug‐induced and rheumatoid vasculitis (RV). At Tokyo Women's Medical University, for the purpose of diagnosing vasculitic neuropathy, we carried out nerve and muscle biopsies in nine RA patients. Unexpectedly, we found three cases of demyelinating neuropathy, together with six cases of RV. Our aim was to investigate the neurophysiological features of demyelinating neuropathy in patients with RA, compared with those of patients with RV. Methods: We reviewed the pathological, clinical and electrophysiological findings in patients with RA who underwent nerve and muscle biopsies. We compared patient demographics and nerve conduction study findings between patients with RV and other patients. Results: The histological findings showed necrotizing vasculitis in six of nine patients. Vasculitis was absent in the other three patients, which showed evidence of demyelination and remyelination. The absence of a sensory nerve action potential and compound motor action potential were observed more frequently in the RV cohort. Sural sparing, shown as the sural‐to‐median sensory nerve action potential ratio, was significantly higher in demyelinating neuropathy patients. Treatment was corticosteroid and cyclophosphamide in RV patients, and intravenous immunoglobulin was administered to three demyelinating neuropathy patients. Treatment response was satisfactory in seven of the nine patients. Conclusion: Demyelinating neuropathy was found more often in patients with RA neuropathy than expected. Sural nerve sparing, as well as the absence of sensory nerve action potential or compound motor action potential, are useful for the differential diagnosis of demyelinating neuropathy with RV in RA patients with neuropathy. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Identification and Quantification of Precursory Changes of Rheumatoid Vasculitis in the Dorsalis Pedis Artery.
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Ren BW, Boman R, Chan RHM, Cheung RTH, Penkala S, Joshua F, and Chiu B
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Objective: Rheumatoid arthritis (RA) is a systemic connective tissue autoimmune disease that can infiltrate arterial walls. The delay in diagnosis and treatment of rheumatoid vasculitis (RV) in patients with RA may lead to irreversible damage to the arterial walls of small-to-medium vessels, which has serious and devastating consequences, most notably lung and cardiac damage. In this work an ultrasound image-based biomarker was developed to detect precursory changes in RV., Methods: The ground truth was initiated from a medical diagnosis of RA, with arterial wall thickening of the proximal dorsalis pedis artery (DPA) indicating precursory changes of RV identified with ultrasound scanning. Ultrasound images of the DPA from 49 healthy subjects in the control group and 46 patients in the RA group were obtained. In total, 187 texture features were extracted from the images, followed by principal component analysis and linear discriminant analysis., Results: The proposed biomarker detected a significant difference between the two groups (p = 5.74 × 10
-18 ) with an area under the receiver operating characteristic curve of 0.85. Ten major textural features contributing most heavily to the biomarker were identified, with these textures being consistent with clinical observations of RV identified in previous studies. Interscan reproducibility was assessed by computing the biomarker twice based on repeated scans of each ankle. High interscan reproducibility was demonstrated by a strong and significant Pearson's coefficient (r = 0.85, p < 0.01) between the two repeated measurements of the proposed biomarker., Conclusion: The proposed biomarker can discriminate image textural differences seen in images acquired from RA patients, demonstrating precursory changes in RV compared with healthy controls. The major discriminative features identified in this study may facilitate the early identification and treatment of RV., Competing Interests: Conflict of interest The authors are in the process of applying for a US patent related to the algorithm proposed in this article. The authors do not have any other competing interests., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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16. Certolizumab pegol treatment for leg ulcers due to rheumatoid vasculitis
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Maureen Tania Meling, MD, Akane Minagawa, MD, PhD, Tomomi Miyake, MD, Atsuko Ashida, MD, PhD, and Ryuhei Okuyama, MD, PhD
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autoimmune disease ,biological therapy ,certolizumab pegol ,leg ulcer ,rheumatoid arthritis ,rheumatoid vasculitis ,Dermatology ,RL1-803 - Published
- 2021
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17. Neurologic Manifestations of Rheumatoid Arthritis
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Yang, Nicole, Coblyn, Jonathan Scott, Cho, Tracey A., editor, Bhattacharyya, Shamik, editor, and Helfgott, Simon, editor
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- 2019
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18. Spinal subarachnoid haemorrhage secondary to spinal rheumatoid vasculitis: a case report.
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Xiao, Yeqing, Yang, Jie, Xia, Jian, Liu, Yunhai, Huang, Qing, and Feng, Jie
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SUBARACHNOID hemorrhage , *VASCULITIS , *RHEUMATOID arthritis , *CENTRAL nervous system , *PATHOGENESIS - Abstract
Introduction: Spinal subarachnoid haemorrhage is extremely rare in cases of subarachnoid haemorrhage and possesses servere characteristics. Additionally, spinal rheumatoid vasculitis is rare for spinal subarachnoid haemorrhage. The pathogenesis is unknown.Case Presentation: A 52-year-old woman with a 10-year history of seropositive rheumatoid arthritis was managed with leflunomide and celecoxib, and stable low disease activity was achieved. The patient had also been diagnosed with spinal subarachnoid haemorrhage secondary to isolated spinal rheumatoid vasculitis and obtained good therapeutic effects.Conclusion: This is the first case to describe spinal subarachnoid haemorrhage secondary to isolated spinal vasculitis in a patient with rheumatoid arthritis, which provides more proof of anomalous neovascularization in the central nervous system in rheumatoid arthritis. [ABSTRACT FROM AUTHOR]- Published
- 2021
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19. Refractory rheumatoid vasculitis complicated by cytomegalovirus reactivation as a manifestation of immune reconstitution inflammatory syndrome
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Michie Katsuta, MD, PhD, Tetsuo Shiohara, MD, PhD, and Akihiko Asahina, MD, PhD
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cutaneous ulcers ,cytomegalovirus reactivation ,immune reconstitution inflammatory syndrome ,rheumatoid arthritis ,rheumatoid vasculitis ,Dermatology ,RL1-803 - Published
- 2020
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20. Rheumatoid Vasculitis in Modern Era: A Case Report and Comprehensive Literature Review.
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Ahmad A, Tariq F, and Zaheer M
- Abstract
Rheumatoid vasculitis (RV) is a rare extraarticular manifestation of severe seropositive rheumatoid arthritis (RA), affecting small and medium vessels and associated with significant morbidity and mortality. The incidence of RV has significantly decreased in the last three decades due to early diagnosis and better management of RA with biologics. Still, the mortality rate remains high and there are insufficient controlled studies guiding RV treatment. Here, we discussed a case of a 75-year-old male who presented with a non-healing ulcer on lateral malleolus without significant joint pain, the workup showed very high titer rheumatoid factor with erosive joint disease raising high clinical suspicion of RV. Skin biopsy was negative for histologic evidence of vasculitis. He had complete healing of the ulcer with prednisone and methotrexate (MTX). This case highlights the importance of promptly recognizing this rare entity and that a negative biopsy does not rule out RV, and appropriate treatment helps decrease morbidity and mortality., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Ahmad et al.)
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- 2024
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21. Inflammatory Arthritides
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Moutsopoulos, Haralampos M., Zampeli, Evangelia, Vlachoyiannopoulos, Panayiotis G., Moutsopoulos, Haralampos M., Zampeli, Evangelia, and Vlachoyiannopoulos, Panayiotis G.
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- 2018
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22. Rheumatoid Vasculitis as an Initial Presentation of Rheumatoid Arthritis
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Sravani Lokineni, Amr Mohamed, Leela Krishna Teja Boppana, and Megha Garg
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rheumatoid vasculitis ,rheumatoid arthritis ,pericarditis ,Medicine - Abstract
Rheumatoid vasculitis is a rare, extra-articular manifestation that can be seen in long-standing rheumatoid arthritis. Here we present the case of a 51-year-old man who presented with arthralgias, skin rash, dyspnoea and generalized leg swelling and who was diagnosed with rheumatoid arthritis flare.
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- 2021
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23. Clinical characteristics and social productivity levels of patients with malignant rheumatoid arthritis based on a nationwide clinical database in Japan: annual survey from 2003 to 2013.
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Yoshiyuki Abe, Keigo Saeki, Hiroaki Dobashi, Tamihiro Kawakami, Taichi Hayashi, Masaki Kobayashi, Shinya Kaname, Masayoshi Harigai, and Naoto Tamura
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RHEUMATOID arthritis , *VASCULITIS , *PULMONARY fibrosis , *PLEURISY - Abstract
Objectives: Malignant rheumatoid arthritis (MRA) is defined as rheumatoid arthritis (RA) with systemic vasculitis or other severe extra-articular manifestations. Japan has a nationwide database for MRA. We analyzed the characteristics of Japanese patients with MRA based on data from the Ministry of Health, Labour and Welfare (MHLW). Methods: We were permitted to use data on 43,108 patients who were registered in the MHLW database from 2003 to 2013. Results: Median age was 65 (interquartile range, 57-72) years. Patients consisted of 71% females. Proportions of patients who had or had experienced interstitial pneumonia and pleuritis were increased, episcleritis was stable, and other MRA manifestations were decreased over time. The number of positive symptoms per patient also decreased over time. The median dose of glucocorticoid, percentage of patients undergoing surgery, and use of non-steroidal anti-inflammatory drugs and apheresis decreased year by year. Steinbrocker stage and class improved over time. Median C-reactive protein levels and erythrocyte sedimentation rate also decreased. Regarding social productivity levels of patients with MRA, the proportion of patients who were working or working from home increased and the proportion of patients recuperating or hospitalized decreased. Conclusion: In patients with MRA, disease activity decreased and social productivity improved from 2003 to 2013. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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24. Biological therapy in rheumatoid vasculitis: a systematic review.
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de Cerqueira, Débora Patrícia Alves, Pedreira, Ana Luisa Souza, de Cerqueira, Marcelo Gomes, and Santiago, Mittermayer Barreto
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BIOTHERAPY , *VASCULITIS , *DIGITAL libraries , *IMMUNOSUPPRESSIVE agents , *ETANERCEPT - Abstract
Rheumatoid vasculitis (RV) is one of the most severe extra-articular manifestations of rheumatoid arthritis, with significant morbidity and mortality, requiring aggressive treatment with corticosteroids and/or immunosuppressants. Recently, biological drugs were included in its therapeutic armamentarium. The objective of this study was to perform a systematic review on the use of biological drugs in the treatment of RV. A systematic literature review was performed based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations and searching articles in MEDLINE/PubMed, Cochrane, SciELO, Scopus, and Virtual Health Library electronic databases. Secondary references were also evaluated. The methodological quality of the selected studies was evaluated by the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria. Altogether, five articles, assessing the use of biological drugs, were included. Globally, 35 patients participated in the studies, of which 21 were treated with rituximab (RTX) in cycles of 1000 mg every 2 weeks; 9 used infliximab 5 mg/kg; 3 used infliximab 3 mg/kg; and 2 used etanercept 25 mg twice/week. In general, an improvement in clinical picture, reduction of the mean daily dose of corticosteroids, and improvement in the Birmingham Vasculitis Activity Score was achieved by the end of the treatment. Complete remission occurred in almost 70% of the cases. The adverse effect rate was 34%, mainly due to infections. There were two deaths, one due to sepsis and the other due to uncontrolled vasculitis, after the biological drug withdrawal, following the development of sepsis. Based on the results of the present review, we believe that the use of biological therapy such as RTX and anti-tumor necrosis factor α can be beneficial in treating this complication. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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25. Case Report: Aortitis associated with rheumatoid arthritis: A challenging rheumatoid vasculitis presentation [version 1; peer review: 2 approved with reservations]
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Zeineb Teyeb, Mohamed Ben Salah, Lobna Kharrat, Imen Abdellali, Taieb Jomni, and Mohamed Hedi Douggui
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Case Report ,Articles ,rheumatoid arthritis ,rheumatoid vasculitis ,aortitis ,immunosuppressive therapy ,case report - Abstract
Rheumatoid vasculitis (RV) is a rare but serious extra-articular manifestation of rheumatoid arthritis (RA). Its varied clinical presentation makes it hard to diagnose and treat. Hereby we describe a case of an aortitis revealing RV, which is a rare presentation of a rare complication of RA. A 56-year-old man with rheumatoid arthritis treated with methotrexate presented with fever, chest pain and arthritis. Blood tests revealed inflammatory syndrome associated with cholestasis. The diagnosis of pericarditis associated with aortitis was retained. Cholestasis was mostly due to methotrexate. The patient was treated with cyclophosphamide pulses and high doses of prednisolone. The patient was in complete remission of articular and extra-articular manifestations after two months of treatment.
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- 2020
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26. A fatal case of diffuse alveolar hemorrhage complicated by rheumatoid arthritis
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Kazuki Nakashima, Naoya Nishimura, Toyoshi Yanagihara, Ayaka Egashira, Naruhiko Ogo, Tatsuma Asoh, Seiji Yoshizawa, and Takashige Maeyama
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Diffuse alveolar hemorrhage ,Rheumatoid arthritis ,Rheumatoid vasculitis ,Anti-citrullinated protein antibodies ,Diseases of the respiratory system ,RC705-779 - Abstract
We describe a fatal case of diffuse alveolar hemorrhage (DAH) complicated by rheumatoid arthritis (RA). A female patient was diagnosed with RA two months earlier and was treated with prednisolone and tacrolimus due to abnormalities in chest images. The patient was admitted to Hamanomachi Hospital for exertional dyspnea and was treated for exacerbation of chronic heart failure. Even after treatment for heart failure, exertional dyspnea remained. Chest CT imaging revealed contractile, patchy consolidations and ground-glass opacities (GGO) with a peribronchial distribution, suggesting an organizing pneumonia (OP) pattern. She was then treated with an additional 25 mg/day of prednisolone following a clinical diagnosis of OP. When the prednisolone dose was tapered, chest imaging showed worsening infiltration. A bronchoscopy was conducted, and bronchoalveolar lavage fluid was sanguineous, indicating DAH. Given that additional workup for the other etiology of DAH was negative, DAH was thought to be related to RA. Intensive treatment, including pulse dose methylprednisolone, failed to halt progression of respiratory failure, leading to a fatal outcome. The clinical presentation proved challenging due to its rarity. DAH might be a differential diagnosis in RA patients with consolidations and GGO in chest CT images. We review past cases of RA-associated DAH and assess potential treatment choices for future cases.
- Published
- 2021
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27. Digital ischemia with Bywaters' lesions in rheumatoid vasculitis.
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Takamasu E, Yokogawa N, and Shimada K
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- Humans, Ischemia diagnostic imaging, Ischemia etiology, Rheumatoid Vasculitis, Acute Kidney Injury
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- 2024
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28. Vasculitis, an Early Unusual Presentation of Rheumatoid Arthritis: A Case Report.
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Kashyap A, Pokhrel B, Bhatta A, Aryal S, and Khanal S
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Rheumatoid arthritis (RA) is a chronic inflammatory disease, with rheumatoid vasculitis (RV) being its most threatening complication. We report a case of a 70-year-old female presenting with gangrene of the tips of fingers and toes early in the course of RA, which is a rare manifestation. The skin is the most commonly affected organ in RV, followed by the peripheral nerves. However, almost every organ system can get implicated. The management of RV is mostly empirical, with high-dose glucocorticoids and cyclophosphamide. Early diagnosis and optimum management are essential in preventing severe complications of the disease., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Kashyap et al.)
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- 2024
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29. Detrimental Effects of Endovascular Intervention in Active Rheumatoid Vasculitis
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Jong Kwon Park
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Endovascular intervention ,Rheumatoid vasculitis ,Thrombosis ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Balloon angioplasty can cause shear stress and tear of the vascular endothelium during mechanical dilatation, leading to increased inflammation and coagulation reactions of the vascular endothelium. Herein, a worst case of active rheumatoid vasculitis is described, where due to progressing ischemic necrosis of the leg, endovascular intervention was unavoidably performed in the presence of active rheumatoid vasculitis. After percutaneous balloon angioplasty, the patient developed recurrent thrombotic occlusion of the leg arteries, and finally, limb amputation resulted in despite vigorous treatment including medication, immunosuppression, catheter-directed thrombolysis, and post-thrombolysis anticoagulation. This case report indicates that endovascular intervention may be detrimental to the active rheumatoid vasculitis. Until the development of treatment guideline to prevent or control inflammatory reaction, endovascular intervention for the active rheumatoid vasculitis may not be appropriate as a first line therapy even though there is progressing ischemic necrosis.
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- 2018
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30. Vasculitic neuropathy associated with Rheumatoid Arthritis, a case report
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Sunita Upreti, Marwa Oudah, Howard Hauptman, and Hmu Minn
- Subjects
rheumatoid vasculitis ,mononeuritis multiplex ,vasculitic neuropathy ,Internal medicine ,RC31-1245 - Abstract
Rheumatoid vasculitis which affects small-to-medium-sized vessels is a rare and late complication of rheumatoid arthritis. It is defined histologically as immune complex deposition in venules, capillaries and arterioles.1 Vasculitis in the vasa nervorum leads to infarction of peripheral nerves which leads to neuropathy. We present a case of mononeuritis multiplex due to rheumatoid vasculitis.
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- 2019
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31. Stroke and Systemic Disease
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Collas, David, Gill, S.K., editor, Brown, M.M., editor, Robertson, F., editor, and Losseff, N., editor
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- 2015
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32. Successful peficitinib monotherapy for the new-onset skin manifestations of rheumatoid vasculitis after long-term treatment with tocilizumab for rheumatoid arthritis.
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Oba Y, Sawa N, Ikuma D, Mizuno H, Inoue N, Sekine A, Hasegawa E, Yamanouchi M, Suwabe T, Yamaguchi Y, Takasawa Y, and Ubara Y
- Subjects
- Female, Humans, Infant, Aged, 80 and over, Rheumatoid Vasculitis diagnosis, Rheumatoid Vasculitis drug therapy, Rheumatoid Vasculitis etiology, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid drug therapy, Antirheumatic Agents adverse effects, Janus Kinase Inhibitors therapeutic use
- Abstract
Rheumatoid vasculitis (RV) is a severe extra-articular systemic manifestation of rheumatoid arthritis (RA). Its prevalence has been decreasing for decades because of improved early diagnosis of RA and advances in RA treatment, but it remains a life-threatening disease. The standard treatment for RV has been a glucocorticoid and disease-modifying antirheumatic drugs. Biological agents, including antitumour necrosis factor inhibitors, are also recommended for refractory cases. However, there are no reports of Janus kinase (JAK) inhibitor use in RV. We experienced a case of an 85-year-old woman with a 57-year history of RA who had been treated with tocilizumab for 9 years after receiving three different biological agents over 2 years. Her RA seemed to be in remission in her joints, and her serum C-reactive protein had decreased to 0.0 mg/dL, but she developed multiple cutaneous leg ulcers associated with RV. Because of her advanced age, we changed her RA treatment from tocilizumab to the JAK inhibitor peficitinib in monotherapy, after which the ulcers improved within 6 months. This is the first report to indicate that peficitinib is a potential treatment option for RV that can be used in monotherapy without glucocorticoids or other immunosuppressants., (© Japan College of Rheumatology 2023. Published by Oxford University Press.)
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- 2023
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33. Diagnosis of Rheumatoid Vasculitis From Ischemic Change in Hands: A Case Report.
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Ohta R and Sano C
- Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disorder with a wide clinical heterogeneity. Among its complications, rheumatoid vasculitis (RV) is notable for its severity and potential to involve multiple organ systems. A particularly serious manifestation of RV is ischemia, which is indicative of advanced vasculitic involvement and a significant risk of tissue damage. This case report describes an 83-year-old male with RA who presented with polyarticular joint pain and hand ischemia. Despite the initial diagnosis of RA exacerbation, worsening systemic symptoms without identifiable infectious causes and hypocomplementemia led to the diagnosis of RV exacerbation. Initial management with steroids showed temporary improvement. However, relapse after dose reduction prompted the administration of rituximab, an anti-cluster-of-differentiate-20 (anti-CD20) monoclonal antibody, which yielded favorable outcomes. This case underscores the importance of clinical vigilance in older patients with RA for signs, such as ischemic hands, emphasizing the pivotal role of early detection and intervention in RV management, particularly in community hospital settings., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Ohta et al.)
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- 2023
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34. Acute Onset Rheumatoid Vasculitis With Polyarthritis and Erythema: A Case Report.
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Amao T, Koda F, Ofuji S, Sano C, and Ohta R
- Abstract
We present the case of a woman in her 70s who was diagnosed with rheumatoid vasculitis (RV) after initially presenting with systemic joint pain and erythema. RV, a rare complication of rheumatoid arthritis, involves inflammation of blood vessels, leading to various skin manifestations. The patient's complaints included fever, generalized joint pain, and skin manifestations that initially resembled erythema multiforme. However, a skin biopsy revealed vasculitis, which guided the RV diagnosis. Although rheumatoid arthritis primarily affects the joints, systemic implications such as RV can arise in rare cases. This case underscores the importance of a holistic and meticulous diagnostic approach, especially in older patients, as early detection and treatment are crucial for managing disease progression and associated complications. Collaborative care involving multidisciplinary teams is vital to achieving optimal outcomes in complex cases., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Amao et al.)
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- 2023
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35. Leg Ulcers
- Author
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Norman, Robert A., Young, Edward M., Jr, Norman, Robert A., and Young, Jr, Edward M.
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- 2014
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36. A case of rheumatoid vasculitis with acquired reactive perforating collagenosis.
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Takaharu Ikeda, Naoya Mikita, Fukumi Furukawa, and Yoshifumi Iwahashi
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- *
RHEUMATOID arthritis , *CORTICOSTEROIDS , *VASCULITIS , *COLLAGEN diseases , *GANGRENE - Abstract
A 55-year-old man with rheumatoid arthritis (RA) presented hyperkeratotic erythematous papules with crusts or blisters on his limbs and buttocks. A histological study showed acquired reactive perforating collagenosis. Soon, skin lesions changed to umbilicated lesions with black necrosis, and the scar from his skin biopsy ulcerated with induration due to rheumatoid vasculitis. Systemic corticosteroids and tacrolimus administration resolved the RA and skin lesions. Rheumatoid vasculitis with acquired reactive perforating collagenosis has not been reported previously. [ABSTRACT FROM AUTHOR]
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- 2019
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37. Reports Outline Rheumatoid Vasculitis Study Results from Dongfang Hospital of Beijing University of Chinese Medicine (Acupuncture for rheumatoid vasculitis complicated by refractory foot ulcer: A case report).
- Subjects
FOOT ulcers ,CHINESE medicine ,UNIVERSITY hospitals ,VASCULITIS ,ACUPUNCTURE - Abstract
A case report from Dongfang Hospital of Beijing University of Chinese Medicine discusses the use of acupuncture as a treatment for rheumatoid vasculitis (RV) complicated by a refractory foot ulcer. RV is a common complication of rheumatoid arthritis (RA) and can result in severe skin vasculitis lesions. In this case, a 62-year-old man with RV developed a foot ulcer that did not respond to traditional treatments. After 12 weeks of acupuncture, the foot ulcer completely healed. The researchers suggest that acupuncture may be a viable alternative treatment for wounds that do not respond to traditional therapies. [Extracted from the article]
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- 2023
38. Rheumatoid vasculitis in 2023: Changes and challenges since the biologics era.
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Mertz, Philippe, Wollenschlaeger, Clara, Chasset, François, Dima, Alina, and Arnaud, Laurent
- Subjects
- *
VASCULITIS , *TAKAYASU arteritis , *DISEASE duration , *SMOKING , *RHEUMATISM , *SYMPTOMS , *POLYARTERITIS nodosa - Abstract
Significant changes in the epidemiology and natural history of rheumatoid vasculitis (RV) have occurred with the introduction of biological therapies such as TNF inhibitors (TNFi) and rituximab. This scoping review aims to address the key current challenges and propose updated criteria for RV. This will aid future descriptive observational studies and prospective therapeutic trials. The MEDLINE database was searched for eligible articles from inception through December 2022. Articles were selected based on language and publication date after 1998, corresponding to the approval of the first TNFi in rheumatic diseases. Sixty articles were included in the review. The mean incidence of RV has decreased since the approval of biologic therapies in RA, from 9.1 (95% CI: 6.8–12.0) per million between 1988 and 2000 to 3.9 (95% CI: 2.3–6.2) between 2001 and 2010, probably due to significant improvement in RA severity and a decrease in smoking habits. Factors associated with an increased risk of RV include smoking at RA diagnosis, longer disease duration, severe RA, immunopositivity, and male gender (regardless of age). Homozygosity for the HLA-DRB104 shared epitope is linked to RV, while the presence of HLA-C3 is a significant predictor of vasculitis in patients without HLA-DRB104. Cutaneous (65–88%), neurologic (35–63%), and cardiac (33%) manifestations are common in RV, often associated with constitutional symptoms (70%). Histologic findings range from small vessel vasculitis to medium-sized necrotizing arteritis, but definite evidence of vasculitis is not required in the 1984 Scott and Bacon diagnostic criteria. Existing data on RV treatment are retrospective, and no formal published guidelines are currently available. The understanding of RV pathogenesis has improved since its initial diagnostic criteria, with a wider range of clinical manifestations identified. However, a validated and updated criteria that incorporates these advances is currently lacking, impeding the development of descriptive observational studies and prospective therapeutic trials. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. • Profound changes in the epidemiology of rheumatoid vasculitis (RV) are noted since the advent of biologics, in particular TNFi • The criteria for RV remain the same since 1984 and do not take into consideration major organs involvements • We suggest updated criteria for RV, which might help homogenize observational studies and prospective therapeutic trials [ABSTRACT FROM AUTHOR]
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- 2023
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39. Study of predictive value of capillaroscopic pattern and serum level of interleukin-17 in rheumatoid vasculitis patients
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Hamdy K Koryem, Manal Y Tayel, Sarah S Eltawab, Reham F Moftah, and Omneya E Elazzazy
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interleukin-17 ,nailfold capillaroscopy ,rheumatoid vasculitis ,Internal medicine ,RC31-1245 - Abstract
Objectives The aim of this study was to investigate nailfold capillaroscopic (NC) abnormalities and serum interleukin (IL)-17) level among rheumatoid arthritis (RA) patients with or without vasculitis. Patients and methods The study was carried on a group of RA Egyptian patients (n=40) who were diagnosed with RA based on ACR criteria. These 40 patients were further divided into two groups. Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6). Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34). All patients were subjected to demographic data collection, clinical examination, Disease Activity Score (DAS) 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anticyclic citrullinated peptide, and IL-17), and NC examination. In addition, group 1 (n=6) was further subjected to electrophysiological evaluation by peripheral nerve conduction studies. Results Significantly elevated levels of IL-17 and characteristic NC changes were seen in RA vasculitis patients. Conclusion Rheumatoid vasculitis is associated with significantly elevated levels of serum IL-17 and characteristic NC changes.
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- 2016
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40. Study of the association between nailfold capillaroscopic changes and serum level of interleukin-17 in rheumatoid: a clue for emerging vaculitis
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H K Koryem, M Y Tayel, S S Eltawab, R F Moftah, and Omneya E Elazzay
- Subjects
interleukin-17 ,nailfold capillaroscopy ,rheumatoid vasculitis ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Objectives The aim of this work was to study nailfold capillaroscopic (NC) abnormalities and serum interleukin-17 (IL-17) level among rheumatoid arthritis (RA) patients and to find whether IL-17 is causally involved in the changes in the capillary vascular bed, such as autoimmune prevasculitic changes. Patients and methods The study was conducted on a group of RA Egyptian patients (n=40) who were diagnosed as having RA based on ACR criteria. Those 40 patients were further divided into two groups. Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6). Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34). All patients were subjected to demographic data collection, clinical examination, disease activity score 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anti-cyclic citrullinated peptide, and IL-17) and NC examination. In addition, group 1 (n=6) was further subjected to electrophysiological evaluation using peripheral nerve conduction studies to determine the effect of vasculitis on the peripheral nerves. Results IL-17 level and NC changes showed a significant association in RA vasculitis patients. Conclusion Elevated levels of serum IL-17 and characteristic NC changes raise their importance in the detection of preclinical rheumatoid vasculitis.
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- 2016
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41. Spinal subarachnoid haemorrhage secondary to spinal rheumatoid vasculitis: a case report
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Jie Yang, Jian Xia, Yunhai Liu, Qing Huang, Jie Feng, and Yeqing Xiao
- Subjects
Vasculitis ,musculoskeletal diseases ,medicine.medical_specialty ,Neurology ,Central nervous system ,Arthritis, Rheumatoid ,Case report ,medicine ,Humans ,Rheumatoid arthritis ,skin and connective tissue diseases ,Rheumatoid vasculitis ,RC346-429 ,Leflunomide ,business.industry ,Spinal subarachnoid haemorrhage ,General Medicine ,Middle Aged ,Subarachnoid Hemorrhage ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Celecoxib ,Female ,Neurology (clinical) ,Neurosurgery ,Neurology. Diseases of the nervous system ,business ,medicine.drug ,Spinal vasculitis - Abstract
Introduction Spinal subarachnoid haemorrhage is extremely rare in cases of subarachnoid haemorrhage and possesses servere characteristics. Additionally, spinal rheumatoid vasculitis is rare for spinal subarachnoid haemorrhage. The pathogenesis is unknown. Case presentation A 52-year-old woman with a 10-year history of seropositive rheumatoid arthritis was managed with leflunomide and celecoxib, and stable low disease activity was achieved. The patient had also been diagnosed with spinal subarachnoid haemorrhage secondary to isolated spinal rheumatoid vasculitis and obtained good therapeutic effects. Conclusion This is the first case to describe spinal subarachnoid haemorrhage secondary to isolated spinal vasculitis in a patient with rheumatoid arthritis, which provides more proof of anomalous neovascularization in the central nervous system in rheumatoid arthritis.
- Published
- 2021
42. Thromboangiitis Obliterans or Buerger's Disease
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Bura, Alessandra, Auriol, Julien, Rousseau, Hervé, Joffre, Francis, Hendaoui, Lotfi, editor, Stanson, Anthony W., editor, Bouhaouala, M. Habib, editor, and Joffre, Francis, editor
- Published
- 2012
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43. Rheumatoid arthritis: A brief overview
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Kajal
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Splenectomy ,Environmental exposure ,Treatment goals ,medicine.disease ,Arthroplasty ,Systemic autoimmune disease ,Rheumatoid arthritis ,Internal medicine ,medicine ,Rheumatoid vasculitis ,Felty Syndrome ,business - Abstract
Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease, affecting the joints with varying severity among patients. The risk factors include age, gender, genetics, and environmental exposure (cigarette smoking, air pollutants, and occupational). Many complications can follow, such as permanent joint damage requiring arthroplasty, rheumatoid vasculitis, and Felty syndrome requiring splenectomy if it remains unaddressed. As there is no cure for RA, the treatment goals are to reduce the pain and stop/slow further damage. Here, we present a brief summary of various past and present treatment modalities to address the complications associated with RA.
- Published
- 2021
44. Small Vessel Vasculitides
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Lamprecht, Peter, Gross, Wolfgang L., and Hertl, Michael, editor
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- 2011
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45. The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis
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Wester Eidi Nishimura, Zoraida Sachetto, Lilian Teresa Lavras Costallat, Michel Alexandre Yazbek, Ana Carolina Santos Londe, Edilaine Gildo Guariento, Silvia Barbosa Dutra Marques, and Manoel Barros Bertolo
- Subjects
Rheumatoid arthritis ,Receptors, KIR ,Rheumatoid vasculitis ,HLA-C antigens/HLA-DRB1 chains ,Medicine (General) ,R5-920 - Abstract
OBJECTIVES: Rheumatoid arthritis is a polygenically controlled systemic autoimmune disease. Rheumatoid vasculitis is an important extra-articular phenotype of rheumatoid arthritis that can result in deep cutaneous ulcers. The objective of this study was to establish a correlation between the frequency of major histocompatibility complex class I/II alleles and killer immunoglobulin-like receptor genotypes in patients with cutaneous rheumatoid vasculitis. METHODS: Using the Scott & Bacon 1984 criteria to diagnose rheumatoid vasculitis and after excluding any other causes such as diabetes, atherosclerosis, adverse drug reactions, infection, and smoking, patients who met the criteria were selected. All of the selected rheumatoid vasculitis patients presented deep cutaneous ulcers. Identification of the major histocompatibility complex class I/II and killer immunoglobulin-like receptor genotypes was performed by polymerase chain reaction assays of samples collected from the 23 rheumatoid vasculitis patients as well as from 80 controls (40 non-rheumatoid vasculitis RA control patients and 40 healthy volunteers). RESULTS: An association between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and cutaneous lesions in rheumatoid vasculitis patients and a correlation between the inhibitor KIR2DL3 and the HLA-C*0802 ligand in rheumatoid vasculitis patients were found. CONCLUSION: An association was found between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and the development of cutaneous lesions in rheumatoid vasculitis patients. Additionally, the HLA-C*0802 ligand protects these individuals from developing cutaneous lesions.
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- 2015
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46. Vasculitis reumatoidea como primera manifestación de artritis reumatoide.
- Author
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Marín-Hernández, Daniela, Orrantia-Vértiz, Mauricio, Barragán-Garfias, Jorge Alberto, and Duarte-Mote, Jesús
- Abstract
The rheumatoid vasculitis is the most serious complication of rheumatoid arthritis, with high morbidity and mortality. It is an inflammatory process that affects small and medium vessels and that has heterogeneous manifestations, being the cutaneous lesions and neuropathy the most common. Its incidence has declined in the last decades because of the early use of disease modifying antirheumatic drugs. Despite the use of cyclophosphamide and the existence of biologic drugs, achieving the control of the disease continues to be a challenge. We present the case of a 50 year-old man, without relevant antecedents, only tabaco use, that presented with a vasculitic neuropathy, rheumatoid factor and cyclic citrullinated peptide antibody positive. This bibliographic review has the intention to update the knowledge of this entity and to be considered a differential diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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47. Rheumatoid Vasculitis
- Author
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Stone, John H., Matteson, Eric L., and Stone, John H., editor
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- 2009
- Full Text
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48. Leukocytapheresis in rheumatoid arthritis.
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Hidaka, Toshihiko, Hashiba, Yayoi, Kubo, Kazuyoshi, Kai, Yasufumi, and Maeda, Keiichi
- Subjects
- *
RHEUMATOID arthritis , *HEMOPERFUSION , *BLOOD transfusion , *VASCULITIS , *PLASMAPHERESIS - Abstract
In this article, we discussed leukocytapheresis (LCAP) for rheumatoid arthritis (RA). Recently, a simple and practical on-line continuous LACP system has been developed. It is equipped with a direct hemoperfusion column (Cellsorba ® , Asahikasei Medical Co., Ltd.) packed with fine-diameter polyester fibers, which are commonly used to adsorb white blood cells to prevent a graft-versus-host reaction during blood transfusion. Clinical trials revealed that LCAP is a effective and safe therapy for patients with drug-resistant RA or RA complicated with vasculitis. Because the procedure is simple and requires no plasma substitutes and the volume needed for extracorporeal circulation is less than that for other plasmapheresis, LCAP might be accepted as an optional therapeutic modality for active RA that was refractory to conventional drug therapy including biological agents. The mechanism of the efficiency of LCAP on RA is unclear. LCAP may cause a reduction of activated T cells from affected joints, down-regulation of Pgp on helper T cells and restoration of Treg function, and that may modify the abnormal cytokine balance. These findings may explain some of the mechanisms by which the articular symptoms are improved by LCAP. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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49. Current clinical evidence of tocilizumab for the treatment of ANCA-associated vasculitis: a prospective case series for microscopic polyangiitis in a combination with corticosteroids and literature review.
- Author
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Sakai, Ryota, Kondo, Tsuneo, Kurasawa, Takahiko, Nishi, Eiko, Okuyama, Ayumi, Chino, Kentaro, Shibata, Akiko, Okada, Yusuke, Takei, Hirofumi, Nagasawa, Hayato, and Amano, Koichi
- Subjects
- *
TOCILIZUMAB , *VASCULITIS treatment , *DRUG efficacy - Abstract
The purpose of this study is to report the efficacy and safety of a combination of tocilizumab (TCZ) and high-dose corticosteroid (CS) in two patients with microscopic polyangiitis (MPA) and review the published current clinical evidence on TCZ in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), except for large vessel vasculitis (LVV) and polymyalgia rheumatica (PMR). Two MPA patients were treated with TCZ at 8 mg/kg every month for 1 year and CS (prednisolone 1 mg/kg/day for 2 weeks, followed by tapering) in a prospective single-arm, single-center, cohort, open-label pilot study (UMIN clinical trials: 000012072). We performed a systematic literature search (PubMed and ICHUSHI [Japan Medical Abstracts Society] until June 30, 2017) to identify published reports on patients with all vasculitis other than LVV/PMR, who were treated with TCZ. We successfully treated the first patient. However, the other patient had serious infection probably associated with the combination of TCZ and high-dose CS. The literature review identified 22 reports with a total of 34 patients who received TCZ for AAV, rheumatoid vasculitis, and other types of vasculitis, in addition to our patients. In 15 of 17 patients (88.2%) with primary and secondary AAV, especially MPA, TCZ induced clinical remission, although TCZ use for rheumatoid vasculitis and vasculitis with mucocutaneous lesions is controversial. This study suggested that TCZ therapy is a potential treatment strategy for patients with AAV. However, TCZ combined with high-dose of CS might not be an appropriate treatment. Future studies are needed to confirm our findings. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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50. Cutaneous Vasculitis
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Ibrahim, Sherrif F., Nousari, Carlos H., Gaspari, Anthony A., editor, and Tyring, Stephen K., editor
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- 2008
- Full Text
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