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4. Evaluating the prospective utility of pharmacogenetics reporting among Canadian Armed Forces personnel receiving pharmacotherapy: a preliminary assessment towards precision psychiatric care

Author

Roth, Maya, King, L, St Cyr, K, Mohsin, U, Balderson, K, Rhind, S, Goldman, A, and Richardson, D

Abstract

Pharmacological interventions for treating posttraumatic stress disorder in Canadian Armed Forces (CAF) members and Veterans often achieve modest results. The field of pharmacogenetics, or the study of how genes influence an individual’s response to different medications, offers insight into how prior knowledge of gene-drug interactions may potentially improve the trial-and-error process of drug selection in pharmacotherapy, thereby improving treatment effects and remission rates. Given the relative recency of pharmacogenetics testing and sparse research in military samples, we used pharmacogenetics testing in a small pilot group (n=23) of CAF members and Veterans who were already engaged in pharmacotherapy for a service-related mental health condition to better understand the associated opportunities and challenges of pharmacogenetics testing in this population. Our preliminary evaluation involved: (1) reporting the prevalence of pharmacogenetics testing ‘bin’ status according to participants’ reports (‘green’, ‘yellow’ or ‘red’; intending to signal ‘go’, ‘caution’ or ‘stop’, regarding the potential for gene-drug interactions); (2) calculating the percentage of currently prescribed psychotropic medications that were assessed and included in the reports; (3) evaluating whether prescribers used pharmacogenetics testing information according to clinical notes and (4) collecting informal feedback from participating psychiatrists. While pharmacogenetics testing appeared to provide valuable information for a number of clients, a major limitation was the number of commonly prescribed medications not included in the reports.

Published
2024
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9. Employability as a Guiding Outcome in Veterinary Education: Findings of the VetSet2Go Project

Author

Cake, M., Bell, M., Cobb, K., Feakes, A., Hamood, W., Hughes, K., King, E., Mansfield, C.F., McArthur, M., Matthew, S., Mossop, L., Rhind, S., Schull, D., Zaki, S., Cake, M., Bell, M., Cobb, K., Feakes, A., Hamood, W., Hughes, K., King, E., Mansfield, C.F., McArthur, M., Matthew, S., Mossop, L., Rhind, S., Schull, D., and Zaki, S.

Abstract

This paper presents a mini-review of employability as a guiding outcome in veterinary education—its conceptualisation, utility, core elements and dimensions, and pedagogical approaches—through a summary of the findings of a major international project with the same aims (the VetSet2Go project). Guided by a conception of the successful veterinary professional as one capable of navigating and sustainably balancing the (sometimes competing) needs and expectations of multiple stakeholders, the project integrated multiple sources of evidence to derive an employability framework representing the dimensions and capabilities most important to veterinary professional success. This framework provides a useful complement to those based in narrower views of competency and professionalism. One notable difference is its added emphasis on broad success outcomes of satisfaction and sustainability as well as task-oriented efficacy, thus inserting “the self” as a major stakeholder and bringing attention to resilience and sustainable well-being. The framework contains 18 key capabilities consistently identified as important to employability in the veterinary context, aligned to five broad, overlapping domains: veterinary capabilities (task-oriented work performance), effective relationships (approaches to others), professional commitment (approaches to work and the broader professional “mission”), psychological resources (approaches to self), plus a central process of reflective self-awareness and identity formation. A summary of evidence supporting these is presented, as well as recommendations for situating, developing, and accessing these as learning outcomes within veterinary curricula. Though developed within the specific context of veterinarian transition-to-practise, this framework would be readily adaptable to other professions, particularly in other health disciplines.

Published
2021

25. Decreased fat content and increased lean in pigs treated with antibodies to adipocyte plasma membranes

Author

Kestin, S., Kennedy, R., Tonner, E., Kiernan, M., Cryer, A., Griffin, H., Butterwith, S., Rhind, S., and Flint, D.

Subjects
Swine -- Breeding, Fat cells -- Research, Meat -- Quality, Immunization -- Research, Zoology and wildlife conservation
Abstract

Antibodies were prepared in sheep against purified plasma membranes from pig adipocytes. Western (immuno) blotting revealed reactions of the antisera with a large number of proteins in adipocyte plasma membranes but remarkably few in plasma membranes from muscle, kidney, liver, lung, brain, spleen, and erythrocytes. This illustrated the high degree of specificity the serum had for adipose tissue. When injected into localized subcutaneous sites such antisera were able to cause considerable adipocyte destruction, which resulted in complete loss of adipose tissue from the site for [less than or equal to] 14 wk. This cell destruction was probably mediated in part by lymphocytic infiltration. Subcutaneous injections were of limited use because of the localized nature of the effects, but, when treatment was administered intraperitoneally, systemic effects were produced that resulted in a 30% reduction in backfat thickness in the region of the last rib and a 25% reduction in fat content of fore- and hind-loin joints that resulted in a significant increase in the percentage of lean tissue. Total feed intake, live weight gain, hot carcass weights, and dressing percentage were unaffected. These results demonstrate the potential for producing long-term reductions in body fat in pigs by an immunization technique that may also provide the unexpected, potential benefit of increased lean deposition. This suggests that fat deposition per se exerts a restrictive influence on lean carcass development. Key Words: Pigs, Adipocytes, Immunization, Growth, Body Composition

Published
1993

29. Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep

Author

Bellingham, M., Fowler, P.A., MacDonald, E.S., Mandon-Pepin, B., Cotinot, C., Rhind, S., Sharpe, R.M., and Evans, N.P.

Abstract

We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary gonadal (HPG) function in sheep. This study investigated whether exposure to ECs only during preconceptional period or only during pregnancy perturbed key regulatory genes within the hypothalamus and pituitary gland and whether these effects were different from chronic (life-long) exposure to biosolid ECs. The findings demonstrate that the timing and duration of maternal EC exposure influences the subsequent effects on the fetal neuroendocrine system in a sex-specific manner. Maternal exposure prior to conception or during pregnancy only, altered the expression of key fetal neuroendocrine regulatory systems such as GnRH and kisspeptin to a greater extent than when maternal exposure was ‘life-long’. Furthermore, hypothalamic gene expression was affected to a greater extent in males than in females, and following EC exposure, male fetuses expressed more “female-like” mRNA levels for some key neuroendocrine genes. This is the first study to show that “real-life” maternal exposure to low levels of a complex cocktail of chemicals prior to conception can subsequently affect the developing fetal neuroendocrine system. These findings demonstrate that the developing neuroendocrine system is sensitive to EC mixtures in a sex-dimorphic manner likely to predispose to reproductive dysfunction in later life.

Published
2016

34. Gastrointestinal barrier dysfunction, endotoxin neutralizing capacity and immuno-inflammatory mediators following repeated exertional heat stress exposure

Author

Selkirk, G. A., Wright, H. E., Rhind, S. G., and McLellan, T. M.

Abstract

Recent evidence in humans has shown a greater endotoxin leakage in sedentary untrained (UT) compared with endurance trained (TR) males at core temperatures below those normally assumed to be essential for the progression of heat illness or heat stroke during acute exertional heat stress (EHS) exposure [1]. Minimal data exists examining the role of gastrointestinal (GI) barrier function, circulating immuno-inflammatory mediators and physiological heat tolerance that accompanies repeated EHS exposures and whether the same cytoprotective responses observed in TR individuals [2] may be induced during repeated EHS in UT. The purpose of this work was to examine the immuno-inflammatory cascades accompanying classical physiological adaptations in untrained males following repeated EHS exposures. Nine UT males (Age = 27 ± 2 years, VO₂peak= 52 ± 2 mL·kgLBM⁻¹·min⁻¹, 17 ± 2% body fatness) walked to exhaustion (EXH) at 4.5 km·h⁻¹ with 2% elevation in a climatic chamber (40°C, 30% R.H.) while wearing encapsulating protective clothing on 9 separate days. Venous whole blood samples were collected at baseline (PRE), 38.0C, 38.5C, 39.0C and EXH on Days 1 and 9, while PRE/EXH samples were drawn on Days 5 and 6. Samples were analyzed for endogenous endotoxin, endotoxin neutralizing capacity (ENC) and for circulating immuno-inflammatory mediators macrophage inflammatory protein (MIP)-1β, IL-6, IL-10, lipopolysaccharide binding protein (LBP), soluble (s) CD14 and extracellular (e) HSP72 by ELISA. In addition, intracellular (i) HSP72 was examined in circulating leukocyte subsets by flow cytometry. Classical physiological adaptations, including reduced HR and increased tolerance time, delta core temperature tolerated, plasma volume and sweat rates were observed during repeated EHS exposure. Mild endotoxemia (21.3 ± 5 pg/mL) was observed at EXH on Days 1, 5, 6, 9 as well as a 14% reduction in ENC (12014 ± 717 vs. 10292 ± 929 ENU/mL) from PRE to EXH on Day 1. Accompanying the changes in endogenous endotoxin and thermoregulatory adaptations were enhanced circulating levels of IL-6, IL-10, LBP, sCD14 as well as cytoprotective increases in both eHSP72 and iHSP72. These findings suggest that GI barrier dysfunction may be an important mechanism of immuno-inflammatory modulation and cytoprotective adaptations observed following repeated EHS exposures., Exercise and Immunity in Athletic Performance and a Healthy Life, 10th ISEI Symposium (International Society of Exercise and Immunology), July 11-13, 2011, Oxford, UK

Published
2011

35. Environmental endocrine disruption of the ovary

Author

Fowler, Paul, Lea, R., Sinclair, K., Pocar, P., Fischer, B., Rhind, S., O'Shaughnessy, P., Cotinot, Corinne, University of Aberdeen, University of Nottingham, UK (UON), Università degli Studi di Milano [Milano] (UNIMI), Martin-Luther-University Halle-Wittenberg, Macaulay Land Use Research Institute, Partenaires INRAE, University of Glasgow, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), EC 7th Framework Programme (FP7/2007-2013), and Nordic Federation of Societies of Obstetrics and Gynecology. DNK.

Subjects
ovary, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, environment, reproductive health, [SDV.BDD]Life Sciences [q-bio]/Development Biology
Abstract

International audience; There is growing evidence that various female reproductive syndromes may be due to environmental chemicals, as is Testis Dysgenesis Syndrome. The detrimental effects of exposure to environmental chemicals include developmental abnormalities, adult dysfunction and cancers in the ovary, urogenital tract, genitalia, mammary gland and hypothalamus/pituitary. Some symptoms, especially premature menarche and premature ovarian ageing, are of considerable concern. This is especially true in countries where women delay childbirth until they reach ages where fecundity would de-facto be reduced even without exposure to environmental chemicals. It is now many years since ovarian formation was thought to be simply due to the absence of SRY and testosterone. We now know that the process leading to a functional ovary in the adult includes complex endocrine signalling. Therefore, the fetal ovary is susceptible to endocrine disruption during development and its controlled development in-utero is critical for the reproductive health of the adult female. Indeed, in women, and model experimental species such as the sheep, the fetal ovary contains the machinery for oestradiol production and reception prior and during to primordial follicle formation. Both real life and experimental exposures have highlighted key mechanisms that are sensitive to environmental chemicals. These include: i) establishment of somatic cell numbers, ii) primordial follicle formation, ii) follicle activation and iv) maintenance of follicle health. All these processes play an important role in the establishment of fecundity in the female and their disturbance by endocrine disruptors is of serious concern.

Published
2010

36. The effects of a cocktail of chemicals contained in sewage sludge on ovine fetal testis development during different periods of gestation

Author

Lea, R. G., Rhind, S., Amezaga, T., Egbowon, Biola, Fischer, Bernd, Pocar, Paola, Cotinot, Corinne, Fowler, Paul, Sinclair, K.D., Schools of Biosciences and Veterinary Medicine and Sciences, University of Nottingham, UK (UON), Macaulay Land Use Research Institute, Partenaires INRAE, Institute of Medical Sciences, University of Aberdeen-School of Medical Sciences, Department of Anatomy and Cell Biology, Martin Luther University, Faculty of Medicine, Department of Animal Science, University of Milan, Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

37. Does grazing on biosolids-treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?

Author

Evans, N. P., Bellingham, M., Sharpe, R. M., Cotinot, C., Rhind, S. M., Kyle, C., Erhard, H., Hombach-Klonisch, S., Lind, Monica, Fowler, P. A., Evans, N. P., Bellingham, M., Sharpe, R. M., Cotinot, C., Rhind, S. M., Kyle, C., Erhard, H., Hombach-Klonisch, S., Lind, Monica, and Fowler, P. A.

Abstract

Biosolids (processed human sewage sludge), which contain low individual concentrations of an array of contaminants including heavy metals and organic pollutants such as polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls (PCB), and polychlorinated dibenzodioxins/polychlorinated dibenzofurans known to cause physiological disturbances, are increasingly being used as an agricultural fertilizer. This could pose a health threat to both humans and domestic and wild animal species. This review summarizes results of a unique model, used to determine the effects of exposure to mixtures of environmentally relevant concentrations of pollutants, in sheep grazed on biosolids-treated pastures. Pasture treatment results in nonsignificant increases in environmental chemical (EC) concentrations in soil. Whereas EC concentrations were increased in some tissues of both ewes and their fetuses, concentrations were low and variable and deemed to pose little risk to consumer health. Investigation of the effects of gestational EC exposure on fetal development has highlighted a number of issues. The results indicate that gestational EC exposure can adversely affect gonadal development (males and females) and that these effects can impact testicular morphology, ovarian follicle numbers and health, and the transcriptome and proteome in adult animals. In addition, EC exposure can be associated with altered expression of GnRH, GnRH receptors, galanin receptors, and kisspeptin mRNA within the hypothalamus and pituitary gland, gonadotroph populations within the pituitary gland, and regional aberrations in thyroid morphology. In most cases, these anatomical and functional differences do not result in altered peripheral hormone concentrations or reproductive function (e.g., lambing rate), indicating physiological compensation under the conditions tested. Physiological compensation is also suggested from studies that indicate that EC effects may be greater when exposure occurs either b

Published
2014
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43. In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling

Author

Fowler, P. A., primary, Childs, A. J., additional, Courant, F., additional, MacKenzie, A., additional, Rhind, S. M., additional, Antignac, J.-P., additional, Le Bizec, B., additional, Filis, P., additional, Evans, F., additional, Flannigan, S., additional, Maheshwari, A., additional, Bhattacharya, S., additional, Monteiro, A., additional, Anderson, R. A., additional, and O'Shaughnessy, P. J., additional

Published
2014
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44. Differential expression of ovine CD1

Author

Rhind, S M, Hopkins, J, and Grant, E S

Subjects
Reverse Transcriptase Polymerase Chain Reaction, Antigens, CD1/metabolism, Gene Expression, hemic and immune systems, chemical and pharmacologic phenomena, Blotting, Northern, complex mixtures, Antigens, CD1/genetics, Sheep/immunology, parasitic diseases, Sheep/genetics, Animals, lipids (amino acids, peptides, and proteins), In Situ Hybridization
Abstract

Differential expression of ovine CD1 was examined using a combination of reverse transcription-polymerase chain reaction (RT-PCR) with sequence-specific primers and Northern and in situ hybridization techniques. The aim of the study was to establish the patterns of CD1 expression at the molecular level and address questions posed by previous studies in other species regarding expression patterns of CD1. A 'pan-CD1' probe based on the exon 4 (alpha 3) region was used in addition to isotype-specific probes for SCD1B (the exon 3 region of clone SCD1B42) and SCD1D (the exon 3 region of clone SCD1D). Widespread expression of CD1 (including thymus, peripheral blood lymphocytes, lung and intestine) was identified using both the exon 4 and SCD1D probe. SCD1B expression was more restricted, being identified in equivalent levels only in the thymus and in scattered populations of dendritic cells. These results highlight the difference in expression patterns between group 1 and group 2 CD1 family members and establish SCD1D as the CD1 family member with the widest pattern of expression, consistent with a differential role for the different CD1 family members.

Published
2000

45. Trauma Association of Canada Annual Scientific Meeting abstractsErythroopoietin resuscitated with normal saline, Ringer’s lactate and 7.5% hypertonic saline reduces small intestine injury in a hemorrhagic shock and resuscitation rat model.Analgesia in the management of pediatric trauma in the resuscitative phase: the role of the trauma centre.Multidisciplinary trauma team care in Kandahar, Afghanistan: current injury patterns and care practices.Does computed tomography for penetrating renal injury reduce renal exploration? An 8-year review at a Canadian level 1 trauma centre.The other side of pediatric trauma: violence and intent injury.Upregulation of activated protein C leads to factor V deficiency in early trauma coagulopathy.A provincial integrated model of improved care for patients following hip fracture.Sports concussion: an Olympic boxing model comparing sex with biomechanics and traumatic brain injury.A multifaceted quality improvement strategy to optimize monitoring and management of delirium in trauma patients: results of a clinician survey.Risk factors for severe all-terrain vehicle injuries in Alberta.Evaluating potential spatial access to trauma centre care by severely injured patients.Incidence of brain injury in facial fractures.Surgical outcomes and the acute care surgery service.The acute care general surgery population and prognostic factors for morbidity and mortality.Disaster preparedness of trauma.What would you like to know and how can we help you? Assessing the needs of regional trauma centres.Posttraumatic stress disorder screening for trauma patients at a level 1 trauma centre.Physical and finite element model reconstruction of a subdural hematoma event.Abdominal wall reconstruction in the trauma patient with an open abdomen.Development and pilot testing of a survey to measure patient and family experiences with injury care.Occult shock in trauma: What are Canadian traumatologists missing?Timeliness in obtaining emergent percutaneous procedures for the severely injured patient: How long is too long?97% of massive transfusion protocol activations do not include a complete hemorrhage panel.Trauma systems in Canada: What system components facilitate access to definitive care?The role of trauma team leaders in missed injuries: Does specialty matter?The adverse consequences of dabigatran among trauma and acute surgical patients.A descriptive study of bicycle helmet use in Montréal.Factor XIII, desmopressin and permissive hypotension enhance clot formation compared with normotensive resuscitation: uncontrolled hemorrhagic shock model.Negative pressure wound therapy for critically ill adults with open abdominal wounds: a systematic review.The “weekend warrior:” Fact or fiction for major trauma?Canadian injury preventon curriculum: a means to promote injury prevention.Penetrating splenic trauma: Safe for nonoperative management?The pediatric advanced trauma life support course: a national initiative.The effectiveness of a psycho-educational program among outpatients with burns or complex trauma.Trauma centre performance indicators for nonfatal outcomes: a scoping review.The evaluation of short track speed skating helmet performance.Complication rates as a trauma care performance indicator: a systematic review.Unplanned readmission following admission for traumatic injury: When, where and why?Reconstructions of concussive impacts in ice hockey.How does head CT correlate with ICP monitoring and impact monitoring discontinuation in trauma patients with a Marshall CT score of I–II?Impact of massive transfusion protocol and exclusion of plasma products from female donors on outcome of trauma patients in Calgary region of Alberta Health Services.Primary impact arthrodesis for a neglected open Weber B ankle fracture dislocation.Impact of depression on neuropsychological functioning in electrical injury patients.Predicting the need for tracheostomy in patients with cervical spinal cord injury.Predicting crumping during computed tomography imaging using base deficit.Feasibility of using telehomecare technology to support patients with an acquired brain injury and family care-givers.Program changes impact the outcomes of severely injured patients.Do trauma performance indicators accurately reflect changes in a maturing trauma program?One-stop falls prevention information for clinicians: a multidisciplinary interactive algorithm for the prevention of falls in older adults.Use of focused assessment with sonography for trauma (FAST) for combat casualties in forward facilities.Alberta All-terrain Vehicle Working Group: a call to action.Observations and potential role for the rural trauma team development course (RTTDC) in India.An electronic strategy to facilitate information-sharing among trauma team leaders.Development of quality indicators of trauma care by a consensus panel.An evaluation of a proactive geriatric trauma consultation service.Celebrity injury-related deaths: Is a gangster rapper really gangsta?Prevention of delirium in trauma patients: Are we giving thiamine prophylaxis a fair chance?Intra-abdominal injury in patients who sustain more than one gunshot wound to the abdomen: Should non-operative management be used?Retrospective review of blunt thoracic aortic injury management according to current treatment recommendations.Telemedicine for trauma resuscitation: developing a regional system to improve access to expert trauma care in Ontario.Comparing trauma quality indicator data between a pediatric and an adult trauma hospital.Using local injury data to influence injury prevention priorities.Systems saving lives: a structured review of pediatric trauma systems.What do students think of the St. Michael’s Hospital ThinkFirst Injury Prevention Strategy for Youth?An evidence-based method for targeting a shaken baby syndrome prevention media campaign.The virtual mentor: cost-effective, nurse-practitioner performed, telementored lung sonography with remote physician guidance.Quality indicators used by teaching versus nonteaching international trauma centres.Compliance to advanced trauma life support protocols in adult trauma patients in the acute setting.Closing the quality improvement loop: a collaborative approach.National Trauma Registry: “collecting” it all in New Brunswick.Does delay to initial reduction attempt affect success rates for anterior shoulder dislocation (pilot study)?Use of multidisciplinary, multi-site morbidity and mortality rounds in a provincial trauma system.Caring about trauma care: public awareness, knowledge and perceptions.Assessing the quality of admission dictation at a level 1 trauma centre.Trauma trends in older adults: a decade in review.Blunt splenic injury in patients with hereditary spherocytosis: a population-based analysis.Analysis of trauma team activation in severe head injury: an institutional experience.ROTEM results correlate with fresh frozen plasma transfusion in trauma patients.10-year trend of assault in Alberta.10-year trend in alcohol use in major trauma in Alberta.10-year trend in major trauma injury related to motorcycles compared with all-terrain vehicles in Alberta.Referral to a community program for youth injured by violence: a feasibility study.New impaired driving laws impact on the trauma population at level 1 and 3 trauma centres in British Columbia, Canada.A validation study of the mobile medical unit/polyclinic team training for the Vancouver 2010 Winter Games.Inferior vena cava filter use in major trauma: the Sunny-brook experience, 2000–2011.Relevance of cellular microparticles in trauma-induced coagulopathy: a systemic review.Improving quality through trauma centre collaboratives.Predictors of acute stress response in adult polytrauma patients following injury.Patterns of outdoor recreational injury in northern British Columbia.Risk factors for loss-to-follow up among trauma patients include functional, socio-economic, and geographic determinants: Would mandating opt-out consent strategies minimize these risks?Med-evacs and mortality rates for trauma from Inukjuak, Nunavik, Quebec.Review of open abdomens in McGill University Health Centre.Are surgical interventions for trauma associated with the development of posttraumatic retained hemothorax and empyema?A major step in understanding the mechanisms of traumatic coagulopathy: the possible role of thrombin activatable fibrinolysis inhibitor.Access to trauma centre care for patients with major trauma.Repeat head computed tomography in anticoagulated traumatic brain injury patients: still warranted.Improving trauma system governance.

Author

Kao, R., primary, Rajagopalan, A., primary, Beckett, A., primary, Rex, R., primary, Shah, S., primary, Waddell, J., primary, Boitano, M., primary, Faidi, S., primary, Babatunde, O., primary, Lawson, F., primary, Grant, A., primary, Sudarshan, M., primary, Takashashi, M., primary, Waggott, M., primary, Lampron, J., primary, Post, A., primary, Beale, E., primary, Bobrovitz, N., primary, Zakrison, T., primary, Smith, A., primary, Bawazeer, M., primary, Evans, C., primary, Leeper, T., primary, Kagedan, D., primary, Grenier, T., primary, Rezendo-Neto, J., primary, Roberts, D., primary, Stark, P., primary, Berg, R., primary, Mehta, S., primary, Gardner, P., primary, Moore, L., primary, Vassilyadi, M., primary, Hoshizaki, B., primary, Rezende-Neto, J., primary, Slaba, I., primary, Ramesh, A., primary, Grigorovich, A., primary, Parry, N., primary, Pajak, C., primary, Rosenbloom, B., primary, Grunfeld, A., primary, van Heest, R., primary, Fernandes, J., primary, Doucet, J., primary, Schooler, S., primary, Ali, J., primary, Klassen, B., primary, Santana, M.J., primary, McFarlan, A., primary, Ball, C., primary, Blackmore, C., primary, Kidane, B., primary, Hicks, C., primary, Brennan, M., primary, Harrington, A.M., primary, Sorvari, A., primary, Stewart, T. Charyk, primary, Biegler, N., primary, Chaubey, V., primary, Tsang, B., primary, Benjamin, S., primary, Hogan, A., primary, Fraser, J., primary, Martin, M., primary, Bridge, J., primary, Waligora, M., primary, Hsiao, M., primary, Sharma, S., primary, Sankarankutty, A., primary, Mckee, J., primary, Snider, C., primary, Szpakowski, J., primary, Brown, R., primary, Shiu, M., primary, Chen, M., primary, Bell, N., primary, Besserer, F., primary, Trudeau, M. O’Neill, primary, Alhabboubi, M., primary, Rizoli, S., primary, Hill, A., primary, Joseph, B., primary, Lawless, B., primary, Jiao, X., additional, Xenocostas, A., additional, Rui, T., additional, Parry, N., additional, Driman, D., additional, Martin, C., additional, Stewart, T. Charyk, additional, Walsh, J., additional, Merritt, N., additional, Elster, E., additional, Tien, H., additional, Phillips, L., additional, Bratu, I., additional, Nascimento, B., additional, Pinto, R., additional, Callum, J., additional, Rizoli, S., additional, McMullan, J., additional, McGlasson, R., additional, Mahomed, N., additional, Flannery, J., additional, Bir, C., additional, Baillie, F., additional, Coates, A., additional, Asiri, S., additional, Foster, P., additional, Bhandari, M., additional, Schuurman, N., additional, Oliver, L., additional, Nathens, A., additional, Yazdani, A., additional, Alhabboubi, M., additional, St. Louis, E., additional, Tan, X., additional, Fata, P., additional, Deckelbaum, D., additional, Chughtai, T., additional, Razek, T., additional, Khwaja, K., additional, Takada, M., additional, Sawano, M., additional, Ito, H., additional, Tsutsumi, H., additional, Keenan, A., additional, Waggott, M., additional, Hoshizaki, B., additional, Brien, S., additional, Gilchrist, M., additional, Janis, J., additional, Phelan, H., additional, Minei, J., additional, Santana, M.J., additional, Stelfox, H.T., additional, McCredie, V., additional, Leung, E., additional, Garcia, G., additional, Dixon, E., additional, Niven, D., additional, Kirkpatrick, A., additional, Feliciano, D., additional, D’Amours, S., additional, Ball, C., additional, Ahmed, N., additional, Izadi, H., additional, McFarlan, A., additional, Pavenski, K., additional, Bridge, J., additional, Tallon, J., additional, Leeper, W., additional, Vogt, K., additional, Gray, D., additional, Ameer, A., additional, Alzaid, S., additional, Drudi, L., additional, Boulva, K., additional, Rodrigue, N., additional, Carreiro, P., additional, Lisboa, T., additional, Winter, P., additional, Ribeiro, E., additional, Cunha-Melo, J., additional, Andrade, M., additional, Zygun, D., additional, Grendar, J., additional, Robertson, H., additional, Ouellet, J.-F., additional, Cheatham, M., additional, McBeth, P., additional, Groff, P., additional, Inaba, K., additional, Okoye, O., additional, Pasley, J., additional, Demetriades, D., additional, Al-Harthi, F., additional, Cheng, A., additional, Lalani, A., additional, Mikrogianakis, A., additional, Cayne, S., additional, Knittel-Keren, D., additional, Gomez, M., additional, Turgeon, A., additional, Lapointe, J., additional, Bourgeois, G., additional, Karton, C., additional, Rousseau, P., additional, Braga, B., additional, Faleiro, R., additional, Magaldi, M., additional, Cardoso, G., additional, Lozada, W., additional, Duarte, L., additional, Oddone-Paolucci, E., additional, Doig, C., additional, Kortbeek, J., additional, Fish, J., additional, Leach, L., additional, Leelapattana, P., additional, Fleming, J., additional, Bailey, C., additional, Nolan, B., additional, DeMestral, C., additional, Zakirova, R., additional, Dabbs, J., additional, Duff, D., additional, Michalak, A., additional, Mitchell, L.A., additional, Singh, M., additional, Topolovec-Vranic, J., additional, Tymianski, D., additional, Yetman, L., additional, Canzian, S., additional, MacPhail, I., additional, Constable, L., additional, van Heest, R., additional, Tam, A., additional, Mahadevan, P., additional, Kim, D., additional, Bansal, V., additional, Casola, G., additional, Coimbra, R., additional, Gladwin, C., additional, Misra, M., additional, Kumar, S., additional, Gautam, S., additional, Sorvari, A., additional, Blackwood, B., additional, Wong, C., additional, Straus, S., additional, Haas, B., additional, Lenartowicz, M., additional, Parkovnick, M., additional, Salim, A., additional, Neto, C., additional, Nogueira, G., additional, Fernandes, M., additional, Almeida, T., additional, de Abreu, E. Maria Savio, additional, Abrantes, W., additional, Taranto, V., additional, Forbes, T., additional, Knight, H., additional, Yoxon, H., additional, Macpherson, A., additional, Mauceri, J., additional, Butorac, E., additional, Holmes, J., additional, Gilliland, J., additional, Healy, M., additional, Tanner, D.A., additional, Polgar, D., additional, Fraser, D.D., additional, Crawford, I., additional, Tiruta, C., additional, Roberts, D., additional, Ferri, M., additional, Bobrovitz, N., additional, Khandwala, F., additional, Widder, S., additional, Mckee, J., additional, Hogan, A., additional, Benjamin, S., additional, Atkinson, P., additional, Watson, I., additional, Woodford, S., additional, Jaramillo, D. 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Published
2012
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48. Efeito da infusão de GnRh nos perfis de LH e na população de folículos ováricos às 7 semanas pósparto em vacas de carne em diferente condição corporal

Author

Andrade, L.P., Rhind, S., Wright, I., and McMillen, S.

Subjects
LH, GnRh, Vaca, Reprodução animal
Abstract

Foi realizada uma experiência com o objectivo de testar a hipótese do anestro pósparto ser superior em vacas de carne em baixa condição corporal (CC) devida a uma reduzida libertação de LH. Vacas Blue—grey (Shorthorn x Galloway) parindo quer em baixa CC (grupo B constituído por 24 animais, CC média de 2,07 (s.e.±0,05) quer em alta CC (grupo A constituído por 12 animais, CC média de 2,81 (s.e. ±0.08)) foram alimentadas de modo a manterem a CC após o parto. Das 5 às 7 semanas pósparto, metade das vacas do grupo B foram submetidas a uma infusão com 2 µg de GnRH em 2 ml de uma solução salina (G) cada 2 horas, tendo-se conseguido induzir ovulação em 10 das 12 vacas. Todas as outras vacas foram submetidas a uma infusão só com uma solução salina (S) durante o mesmo período e a ovulação foi induzida somente em 1 das 12 vacas em alta CC e em uma das 11 vacas em baixa CC. Os perfis de libertação de gonadotrofinas, a frequência e a amplitude da libertação de LH, não foram afectados, quer pela infusão com GnRH, quer pela CC. O número de folículos pequenos (3-7,9 mm de diâmetro) e grandes (> 8mm de diâmetro) presentes à 7.ª semana pósparto, o número de receptores para a LH na teca e na granulosa e de FSH na granulosa, bem como o número de células da granulosa presentes nos folículos grandes à 7.ª semana pósparto, não evidenciam diferenças significativas (P>0,05). As concentrações intrafoliculares de estradiol, testosterona e de IGF-I nos folículos grandes, à 7.ª semana pósparto, não foram significativamente afectados, nem pela infusão de GnRH, nem pela CC. Contudo, observou-se uma tendência para elevadas concentrações de estradiol em vacas em alta CC quando comparada com vacas em baixa CC. Os resultados sugerem que a infusão de GnRH acelerou o processo de desenvolvimento folicular nas vacas em baixa CC ; outros factores além da CC poderão estar envolvidos do desenvolvimento folicular.

Published
1994

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