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15 results on '"Rhodes, Brianna"'

1. Engineered immunogens to elicit antibodies against conserved coronavirus epitopes

Author

Kapingidza, A. Brenda, Marston, Daniel J., Harris, Caitlin, Wrapp, Daniel, Winters, Kaitlyn, Mielke, Dieter, Xiaozhi, Lu, Yin, Qi, Foulger, Andrew, Parks, Rob, Barr, Maggie, Newman, Amanda, Schäfer, Alexandra, Eaton, Amanda, Flores, Justine Mae, Harner, Austin, Catanzaro, Jr., Nicholas J., Mallory, Michael L., Mattocks, Melissa D., Beverly, Christopher, Rhodes, Brianna, Mansouri, Katayoun, Van Itallie, Elizabeth, Vure, Pranay, Dunn, Brooke, Keyes, Taylor, Stanfield-Oakley, Sherry, Woods, Christopher W., Petzold, Elizabeth A., Walter, Emmanuel B., Wiehe, Kevin, Edwards, Robert J., Montefiori, David C., Ferrari, Guido, Baric, Ralph, Cain, Derek W., Saunders, Kevin O., Haynes, Barton F., and Azoitei, Mihai L.

Published
2023
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2. MILITARY NEWS

Author

Narduzzi, Anna L., Rhodes, Brianna, Andreoli, Linda, Watson, Caycee, Gruwell, Kristine, Guard, Wyoming National, Hatch, Damion, and Lewis, Peter

Published
2019

4. Engineered Immunogens to Expose Conserved Epitopes Targeted by Broad Coronavirus Antibodies

Author

Kapingidza, Brenda, primary, Marston, Daniel J., additional, Harris, Caitlin, additional, Wrapp, Daniel, additional, Winters, Kaitlyn, additional, Rhodes, Brianna, additional, Vure, Pranay, additional, Woods, Christopher W., additional, Petzold, Elizabeth A., additional, Walter, Emmanuel B, additional, Parks, Rob, additional, Barr, Maggie, additional, Yin, Qi, additional, Cain, Derek W., additional, Wiehe, Kevin, additional, Saunders, Kevin O., additional, Haynes, Barton F., additional, and Azoitei, Mihai L., additional

Published
2023
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6. Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations

Author

Swanson, Olivia, primary, Rhodes, Brianna, additional, Wang, Avivah, additional, Xia, Shi-Mao, additional, Parks, Robert, additional, Chen, Haiyan, additional, Sanzone, Aja, additional, Cooper, Melissa, additional, Louder, Mark K., additional, Lin, Bob C., additional, Doria-Rose, Nicole A., additional, Bonsignori, Mattia, additional, Saunders, Kevin O., additional, Wiehe, Kevin, additional, Haynes, Barton F., additional, and Azoitei, Mihai L., additional

Published
2021
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7. RECENT KILLINGS STRENGTHEN MOVEMENT FOR BLACK LIBERATION.

Author

Collins, Sam P. K. and Rhodes, Brianna N.

Subjects
YOUTH protest movements, LEGAL status of African Americans, CRIMES against African Americans, POLICE, LIBERTY, ACTIONS & defenses (Law)
Abstract

The article discusses the move of African American Millennials to strengthen their fight for Black liberation due to the killings of African Americans by police officers in 2016. Topics include the protests of African American youth in the Washington D.C. metro area, the operations of Fraternal Order of Police and police unions, and the involvement of police officers in African Americans civilian deaths.

Published
2016

9. Black Student Leader Galvanizes Millennial Votes.

Author

Rhodes, Brianna N.

Subjects
BLACK college students, MILLENNIALS, UNITED States presidential election, 2016
Abstract

The article focuses on Abeke Teyibo, president of the Black Student Union (BSU) at The George Washington University (GWU) in Washington, D.C., and her efforts to encourage millennials to vote in the 2016 presidential election. Topics include Teyibo's explanation on the importance for African American students to vote, the efforts by presidential candidates Hillary Clinton and Donald Trump to gain support from African Americans, and the BSU's political panels discussing social injustice.

Published
2016

10. MILLENNIALS DIVIDED OVER HILLARY AND BERNIE.

Author

Rhodes, Brianna

Subjects
MILLENNIALS, PRESIDENTIAL candidates, UNITED States presidential election, 2016, POLITICAL attitudes
Abstract

The article reports on the reasons given by Millennials for supporting either Hillary Clinton or Bernie Sanders as the Democratic Party's presidential nominee for the 2016 U.S. elections. Topics discussed include North Carolina resident Aubrey Davis stating that she supports Sanders because she feels that Sanders empathizes with Millennials and Maryland resident Osi Osman admitting that he supports Clinton because he does not want Republican Party presumptive nominee Donald Trump to win.

Published
2016

11. MILLENNIALS CELEBRATE THE BLACK PANTHERS' 50TH ANNIVERSARY.

Author

Rhodes, Brianna

Subjects
MILLENNIALS, POLICE & minorities, MILITARIZATION of police, POLICE-community relations, POLICE brutality
Abstract

The article reports on the celebration of millennials of the 50th anniversary of the Black Panther Party for Self-Defense, a movement that fights against militaristic police forces in the U.S. It highlights the halftime performance of singer Beyoncé for the Super Bowl 50 football game, where she paid tribute to the Black Panthers. It also discusses the historical significance of the Party's fight against police brutality and other social and economic issues that affect black communities.

Published
2016

12. MILLENNIALS WEIGH IN ON OBAMA'S FINAL SOTU ADDRESS.

Author

Rhodes, Brianna

Subjects
STATE of the Union messages, INTERNATIONAL relations, PATIENT Protection & Affordable Care Act, CIVIL rights, GUN control
Abstract

The article focuses on the State of the Union (SOTU) address by the U.S. President Barack Obama on January 12, 2016. Topics mentioned include the international relations management, the Affordable Care Act, health insurance in the U.S., and the civil rights management. Also mentioned are the foreign relations of the country and the gun violence management.

Published
2016

13. LOCAL FASHION DESIGNERS CELEBRATE THE CRAFT.

Author

Rhodes, Brianna

Subjects
FASHION shows, EXHIBITIONS
Abstract

The article reviews the D. C. Fashion Week held in Washington, D. C. and the New York Fashion Week held at Skylight at Moynihan Station and Skylight Clarkson Square in New York in September 2015 featuring fashion designers Michelle Gibson, Kelsy Dominick, and Velicia Steadman.

Published
2015

14. A high affinity monoclonal antibody against HLA-E-VL9 enhances natural killer cell anti-tumor killing.

Author

Hwang JK, Marston DJ, Wrapp D, Li D, Tuyishime M, Brackenridge S, Rhodes B, Quastel M, Kapingidza AB, Gater J, Harner A, Wang Y, Rountree W, Ferrari G, Borrow P, McMichael AJ, Gillespie GM, Haynes BF, and Azoitei ML

Abstract

Natural killer (NK) cells kill target cells following triggering via germline-encoded receptors interacting with target cell-expressed ligands (direct killing), or via antibody-dependent cellular cytotoxicity (ADCC) mediated by FcγRIIIa. NK cytotoxicity is modulated by signaling through activating or inhibitory receptors. A major checkpoint is mediated by the NK inhibitory receptor NKG2A/CD94 and its target cell ligand, HLA-E, which is complexed with HLA signal sequence-derived peptides termed VL9 (HLA-E-VL9). We have previously reported the isolation of a murine HLA-E-VL9-specific IgM antibody 3H4 and the generation of a higher affinity IgG version (3H4v3). Here we have used phage display library selection to generate a high affinity version of 3H4v3, called 3H4v31, with an ∼700 fold increase in binding affinity. We show using an HLA-E-VL9+ K562 tumor model that, in vitro, the addition of 3H4v31 to target cells increased direct killing of targets by CD16-negative NK cell line NK-92 and also mediated ADCC by NK-92 cells transfected with CD16. Moreover, ADCC by primary NK cells was also enhanced in vitro by 3H4v31. 3H4v31 was also able to bind and enhance target cell lysis of endogenously expressed HLA-E-VL9 on human cervical cancer and human pancreatic cancer cell lines. In vivo, 3H4v31 slowed the growth rate of HLA-E-VL9+ K562 tumors implanted into NOD/SCID/IL2rγ null mice compared to isotype control when injected with NK-92 cells intratumorally. Together, these data demonstrate that mAb 3H4v31 can enhance NK cell killing of HLA-E-VL9-expressing tumor cells in vitro by both direct killing activity and by ADCC. Moreover, mAb 3H4v31 can enhance NK cell control of tumor growth in vivo. We thus identify HLA-E-VL9 monoclonal antibodies as a promising novel anti-tumor immunotherapy., One Sentence Summary: A high affinity monoclonal antibody against HLA-E-VL9 enhances natural killer cell anti-tumor killing by checkpoint inhibition and antibody dependent cellular cytotoxicity.

Published
2024
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15. Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes.

Author

Kapingidza B, Marston DJ, Harris C, Wrapp D, Winters K, Mielke D, Xiaozhi L, Yin Q, Foulger A, Parks R, Barr M, Newman A, Schäfer A, Eaton A, Flores JM, Harner A, Cantazaro NJ, Mallory ML, Mattocks MD, Beverly C, Rhodes B, Mansouri K, Itallie EV, Vure P, Manness B, Keyes T, Stanfield-Oakley S, Woods CW, Petzold EA, Walter EB, Wiehe K, Edwards RJ, Montefiori D, Ferrari G, Baric R, Cain DW, Saunders KO, Haynes BF, and Azoitei ML

Abstract

Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassing residues 815-823 adjacent to the fusion peptide, are highly conserved across sarbecoviruses and are recognized by broadly reactive antibodies, providing hope that vaccines targeting these epitopes could offer protection against both current and emergent viruses. Here we employed computational modeling to design scaffolded immunogens that display the spike 815-823 peptide and the stem helix epitopes without the distracting and immunodominant RBD. These engineered proteins bound with high affinity and specificity to the mature and germline versions of previously identified broadly protective human antibodies. Epitope scaffolds interacted with both sera and isolated monoclonal antibodies with broadly reactivity from individuals with pre-existing SARS-CoV-2 immunity. When used as immunogens, epitope scaffolds elicited sera with broad betacoronavirus reactivity and protected as "boosts" against live virus challenge in mice, illustrating their potential as components of a future pancoronavirus vaccine.

Published
2023
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