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38 results on '"Ribas, Judit"'

1. Data from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth

Author

Ribas, Judit, primary, Ni, Xiaohua, primary, Haffner, Michael, primary, Wentzel, Erik A., primary, Salmasi, Amirali Hassanzadeh, primary, Chowdhury, Wasim H., primary, Kudrolli, Tarana A., primary, Yegnasubramanian, Srinivasan, primary, Luo, Jun, primary, Rodriguez, Ron, primary, Mendell, Joshua T., primary, and Lupold, Shawn E., primary

Published
2023
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2. Supplementary Methods, Figures 1-5, Tables 1-2 from miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth

Author

Ribas, Judit, primary, Ni, Xiaohua, primary, Haffner, Michael, primary, Wentzel, Erik A., primary, Salmasi, Amirali Hassanzadeh, primary, Chowdhury, Wasim H., primary, Kudrolli, Tarana A., primary, Yegnasubramanian, Srinivasan, primary, Luo, Jun, primary, Rodriguez, Ron, primary, Mendell, Joshua T., primary, and Lupold, Shawn E., primary

Published
2023
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8. Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells

Author

Martínez-Escardó, Laura, primary, Alemany, Montse, additional, Sánchez-Osuna, María, additional, Sánchez-Chardi, Alejandro, additional, Roig-Martínez, Meritxell, additional, Suárez-García, Salvio, additional, Ruiz-Molina, Daniel, additional, Vidal, Noemi, additional, Plans, Gerard, additional, Majós, Carles, additional, Ribas, Judit, additional, Baltrons, María Antonia, additional, Bayascas, Jose R., additional, Barcia, Carlos, additional, Bruna, Jordi, additional, and Yuste, Victor J., additional

Published
2021
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10. Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

Author

Ni, Xiaohua, Zhang, Yonggang, Ribas, Judit, Chowdhury, Wasim H., Castanares, Mark, Zhang, Zhewei, Laiho, Marikki, DeWeese, Theodore L., and Lupold, Shawn E.

Subjects
Johns Hopkins University. School of Medicine, Health aspects, Nuclear radiation -- Health aspects, Tumors -- Health aspects, Radiotherapy -- Health aspects, Prostate cancer -- Health aspects, RNA -- Health aspects
Abstract

Dose-escalated radiation therapy for localized prostate cancer (PCa) has a clear therapeutic benefit; however, escalated doses may also increase injury to noncancerous tissues. Radiosensitizing agents can improve ionizing radiation (IR) [...]

Published
2011
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14. Gossypol Treatment Restores Insufficient Apoptotic Function of DFF40/CAD in Human Glioblastoma Cells

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat de Catalunya, European Commission, Universidad Autónoma de Barcelona, Martínez-Escardó, Laura, Alemany, Montse, Sánchez-Osuna, María, Sánchez-Chardi, Alejandro, Roig-Martínez, Meritxell, Suárez-García, Salvio, Ruiz Molina, Daniel, Vidal, Noemí, Plans, Gerard, Majós, Carles, Ribas, Judit, Baltrons, María Antonia, Bayascas, Jose R., Barcia, Carlos, Bruna, Jordi, Yuste, Víctor J., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat de Catalunya, European Commission, Universidad Autónoma de Barcelona, Martínez-Escardó, Laura, Alemany, Montse, Sánchez-Osuna, María, Sánchez-Chardi, Alejandro, Roig-Martínez, Meritxell, Suárez-García, Salvio, Ruiz Molina, Daniel, Vidal, Noemí, Plans, Gerard, Majós, Carles, Ribas, Judit, Baltrons, María Antonia, Bayascas, Jose R., Barcia, Carlos, Bruna, Jordi, and Yuste, Víctor J.

Abstract

Glioblastoma (GBM) is a highly aggressive brain tumor and almost all patients die because of relapses. GBM-derived cells undergo cell death without nuclear fragmentation upon treatment with different apoptotic agents. Nuclear dismantling determines the point-of-no-return in the apoptotic process. DFF40/CAD is the main endonuclease implicated in apoptotic nuclear disassembly. To be properly activated, DFF40/CAD should reside in the cytosol. However, the endonuclease is poorly expressed in the cytosol and remains cumulated in the nucleus of GBM cells. Here, by employing commercial and non-commercial patient-derived GBM cells, we demonstrate that the natural terpenoid aldehyde gossypol prompts DFF40/CAD-dependent nuclear fragmentation. A comparative analysis between gossypol- and staurosporine-treated cells evidenced that levels of neither caspase activation nor DNA damage were correlated with the ability of each compound to induce nuclear fragmentation. Deconvoluted confocal images revealed that DFF40/CAD was almost completely excluded from the nucleus early after the staurosporine challenge. However, gossypol-treated cells maintained DFF40/CAD in the nucleus for longer times, shaping a ribbon-like structure piercing the nuclear fragments and building a network of bridged masses of compacted chromatin. Therefore, GBM cells can fragment their nuclei if treated with the adequate insult, making the cell death process irreversible.

Published
2021

21. Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population

Author

Brebi, Priscilla, primary, Maldonado, Leonel, additional, Noordhuis, Maartje G, additional, Ili, Carmen, additional, Leal, Pamela, additional, Garcia, Patricia, additional, Brait, Mariana, additional, Ribas, Judit, additional, Michailidi, Christina, additional, Perez, Jimena, additional, Soudry, Ethan, additional, Tapia, Oscar, additional, Guzman, Pablo, additional, Muñoz, Sergio, additional, Van Neste, Leander, additional, Van Criekinge, Wim, additional, Irizarry, Rafael, additional, Sidransky, David, additional, Roa, Juan C, additional, and Guerrero-Preston, Rafael, additional

Published
2013
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26. miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth

Author

Ribas, Judit, primary, Ni, Xiaohua, additional, Haffner, Michael, additional, Wentzel, Erik A., additional, Salmasi, Amirali Hassanzadeh, additional, Chowdhury, Wasim H., additional, Kudrolli, Tarana A., additional, Yegnasubramanian, Srinivasan, additional, Luo, Jun, additional, Rodriguez, Ron, additional, Mendell, Joshua T., additional, and Lupold, Shawn E., additional

Published
2009
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29. Sexualidad, psicoanálisis y crítica feminista

Author

Ribas, Judit and Ribas, Judit

Abstract

No abstract available.Realidad: Revista de Ciencias Sociales y Humanidades No. 72, 1999: 759-776, No hay resúmenes disponiblesRealidad: Revista de Ciencias Sociales y Humanidades No. 72, 1999: 759-776

Published
1999

30. En defensa de Maquiavelo

Author

Ribas, Judit and Ribas, Judit

Abstract

No abstract available.Realidad: Revista de Ciencias Sociales y Humanidades No. 61, 1998: 77-89, No hay resúmenes disponiblesRealidad: Revista de Ciencias Sociales y Humanidades No. 61, 1998: 77-89

Published
1998

36. Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506-binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population.

Author

Brebi, Priscilla, Maldonado, Leonel, Noordhuis, Maartje G., Ili, Carmen, Leal, Pamela, Garcia, Patricia, Brait, Mariana, Ribas, Judit, Michailidi, Christina, Perez, Jimena, Soudry, Ethan, Tapia, Oscar, Guzman, Pablo, Muñoz, Sergio, Van Neste, Leander, Van Criekinge, Wim, Irizarry, Rafael, Sidransky, David, Roa, Juan C., and Guerrero-Preston, Rafael

Published
2014
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37. A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population.

Author

Tonghai Dou, Qihan Wu, Xin Chen, Ribas, Judit, Xiaohua Ni, Cheng Tang, Fengping Huang, Liangfu Zhou, and Daru Lu

Subjects
RNA, GENETIC polymorphisms, GENE expression, GLIOMAS, NERVOUS system tumors
Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in regulation of eukaryotic gene expression. Aberrant expression and structural alternation of miRNAs are considered to participate in tumorigenesis and cancer development. Recently, different genotypes of miR- 196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer. To further investigate whether this polymorphism may influence glioma risk or not, we examined the SNP allele frequency in Chinese population. Our data shows the genotype CC of miR- 196a (rs11614913) polymorphism is associated with decreased risk of glioma in the Chinese population (OR = 0.74, 95% CI:0.56-0.98). Furthermore, a significant association was observed between this genotype and glioma risk in the subgroups of adult glioma (OR = 0.73, 95% CI:0.55-0.98), male glioma (OR = 0.69, 95% CI:0.48-0.99) and patients with glioblastoma (OR = 0.58, 95% CI:0.37-0.91). This was the first study investigating the association between the miR-196a rs11614913 and glioma risk. Compared with the results from previous studies in lung cancer and breast cancer, our data suggest a different genotype association in glioma. This may be related to the diversity on the tissue origin, tumor type, tumorigenesis, and developing process. [ABSTRACT FROM AUTHOR]

Published
2010
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38. Investigation of miR-21, miR-141, and miR-221 expression levels in prostate adenocarcinoma for associated risk of recurrence after radical prostatectomy

Author

Zheng, Qizhi, Peskoe, Sarah B., Ribas, Judit, Rafiqi, Fatema, Kudrolli, Tarana, Meeker, Alan K., De Marzo, Angelo M., Platz, Elizabeth A., and Lupold, Shawn E.

Subjects
Male, Prostatectomy, Bioquímica, Prostate cancer, Càncer de pròstata, Incidence, Prostatic Neoplasms, Pilot Projects, Adenocarcinoma, Middle Aged, Prognosis, Biochemistry, Article, Gene Expression Regulation, Neoplastic, MicroRNAs, Treatment Outcome, Risk Factors, Case-Control Studies, Multivariate Analysis, Biomarkers, Tumor, Humans, Neoplasm Recurrence, Local, Aged, Neoplasm Staging
Abstract

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that regulate a broad array of cellular and disease processes. Several miRNAs are differentially expressed in cancer and many are being considered as biomarkers for predicting clinical outcomes. Here we quantified the expression of three miRNAs, miR-21, miR-141, and miR-221, from prostate cancer surgical specimens and evaluated their association with disease recurrence after primary therapy. METHODSA pilot nested case-control study was designed from a large cohort of men who underwent radical prostatectomy between 1993 and 2001. Total RNA was extracted from malignant prostate tissue of 59 cases (recurrence) and 59 controls. Cases and controls were matched on age, race, pathologic stage, and grade. The relative expression of each miRNA was then determined for each sample by quantitative real-time RT-PCR. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) of recurrence for tertiles of miRNA expression. We noted block storage time effects and thus, used separate tertile cutpoints based on the controls by calendar year of prostatectomy. RESULTSLower miR-221 expression was associated with a higher risk of recurrence; the ORs were 3.21 for the lowest tertile and 2.63 for the middle tertile compared with the highest tertile of expression (P-trend=0.02). This pattern was unchanged after multivariable adjustment (P-trend=0.05). No statistically significant trends were observed for miR-21 or miR-141 after multivariable adjustment. CONCLUSIONSBased on this small pilot study, men with localized prostate cancers with lower miR-221 expression may have a greater risk for recurrence after surgery Funding for this project was supported by grants from the National Institutes of Health 5R01CA143299, 5P50CA058236, Patrick C. Walsh Prostate Cancer Research Fund, the Department of Defense Prostate Cancer Research Program Award numbers W81XWH-10-2- 0056, W81XWH-05-1-0030 and W81XWH-10-2-0046 Prostate Cancer Biorepository Network (PCBN).numbers W81XWH-10-2-0056, W81XWH-05-1-0030 and W81XWH-10-2-0046 Prostate Cancer Biorepository Network (PCBN)

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