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3. Effects of gastric bypass on the digestibility and postprandial metabolic fate of 15N dietary protein in rats.

Author

Benhaddou, Soukaïna, Ribeiro-Parenti, Lara, Khodorova, Nadezda, Willemetz, Alexandra, Chapelais, Martin, Azzout-Marniche, Dalila, Le Gall, Maude, and Gaudichon, Claire

Subjects
*GASTRIC bypass, *DIETARY proteins, *GASTROINTESTINAL system, *PROTEIN synthesis, *RATS
Abstract

Roux-en-Y Gastric Bypass may be associated with an alteration of protein bioavailability in relation to intestinal remodeling. Our study aimed to test this hypothesis by Roux-en-Y Gastric Bypass. Diet-induced obese rats underwent Roux-en-Y Gastric Bypass surgery (RYGB rats) while a Sham-operated control group was used. All rats received a 15N-labeled protein meal 1 or 3 months after surgery and were euthanized 6h later. Protein digestibility, 15N recovered in organs and urea pool, fractional protein synthesis rate, and intestinal morphometry were assessed. Protein digestibility was similar in all groups (94.2±0.3%). The small intestine was hypertrophied in RYGB rats 1 month after surgery, weighing 9.1±0.2g vs. 7.0±0.3g in Sham rats (P = 0.003). Villus height and crypt depth were increased in the alimentary limb and ileum of RYGB rats. However, Roux-en-Y Gastric Bypass had no impact on the fractional synthesis rate. In the gastrointestinal tract, 15N retention only differed in the ileal mucosa and was higher in RYGB rats at 1 month (0.48±0.2% vs. 0.3±0.09%, P = 0.03). 15N recovery from the liver, muscle, and skin was lower in RYGB rats at 1 month. 15N recovery from urinary and plasma urea was higher in RYGB rats at both times, resulting in increased total deamination (13.2±0.9% vs. 10.1±0.5%, P<0.01). This study showed that Roux-en-Y Gastric Bypass did not affect protein digestibility. Dietary nitrogen sequestration was transitorily and moderately diminished in several organs. This was associated with a sustained elevation of postprandial deamination after Roux-en-Y Gastric Bypass, whose mechanisms merit further studies. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

Author

Ribeiro-Parenti, Lara, Jarry, Anne-Charlotte, Cavin, Jean-Baptiste, Willemetz, Alexandra, Le Beyec, Johanne, Sannier, Aurélie, Benadda, Samira, Pelletier, Anne-Laure, Hourseau, Muriel, Léger, Thibaut, Morlet, Bastien, Couvelard, Anne, Anini, Younes, Msika, Simon, Marmuse, Jean-Pierre, Ledoux, Sévérine, Le Gall, Maude, and Bado, André

Published
2021
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17. Fecal microbiota transplantation in a rodent model of short bowel syndrome: A therapeutic approach?

Author

Fourati, Salma, primary, Dumay, Anne, additional, Roy, Maryline, additional, Willemetz, Alexandra, additional, Ribeiro-Parenti, Lara, additional, Mauras, Aurélie, additional, Mayeur, Camille, additional, Thomas, Muriel, additional, Kapel, Nathalie, additional, Joly, Francisca, additional, Le Gall, Maude, additional, Bado, André, additional, and Le Beyec, Johanne, additional

Published
2023
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18. Roux-en-Y Gastric-Bypass and sleeve gastrectomy induces specific shifts of the gut microbiota without altering the metabolism of bile acids in the intestinal lumen

Author

Duboc, Henri, Nguyen, Caroline, Cavin, Jean-Baptiste, Ribeiro-Parenti, Lara, Jarry, Anne-Charlotte, Rainteau, Dominique, Humbert, Lydie, Coffin, Benoit, Le Gall, Maude, Bado, André, and Sokol, Harry

Abstract

Some shifts in the gut microbiota composition and its metabolic fingerprints have been associated to Sleeve gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB). So far, plasma bile acids have been associated with post-operative glucose improvement and weight loss, but nothing is known about their metabolism in the gut lumen. As bile acids are physiologically transformed by the microbiota into various species, the aim of this work was to study how SG and RYGB-associated dysbiosis impact the bioconversion of bile acids in the intestinal lumen. Comparing SHAM (n= 9) with our validated rat models of SG (n= 5) and RYGB (n= 6), we quantified luminal bile acids along the gut and found that the metabolic transformation of bile acids (deconjugation, dehydroxylation, and epimerization) is not different from the duodenum to the colon. However, in the cecum where the biotransformation mainly takes place, we observed deep alterations of the microbiota composition, which were specific of each type of surgery. In conclusion, despite specific dysbiosis after surgery, the bile acids metabolism in the gut lumen is highly preserved, suggesting that a resilience of the gut microbiota occurs after these procedures.

Published
2024
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27. What's new in postoperative intensive care after bariatric surgery?

Author

Montravers, Philippe, Ribeiro-Parenti, Lara, and Welsch, Camille

Subjects
Obesity -- Surgery, Health care industry
Abstract

Author(s): Philippe Montravers [sup.1], Lara Ribeiro-Parenti [sup.2], Camille Welsch [sup.1] Author Affiliations: (1) grid.7452.4, 0000000122170017, Departement d'Anesthésie Réanimation, CHU Bichat-Claude Bernard, APHP, Université Paris Diderot-PRESS Sorbonne Cite, , 46, Rue [...]

Published
2015
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31. Conséquences du bypass gastrique à une anastomose sur la muqueuse oeso-gastrique dans un modèle préclinique murin

Author

Siebert, Matthieu, Ribeiro-Parenti, Lara, Nguyen, Nicholas, Hourseau, Muriel, Duchêne, Belinda, Humbert, Lydie, Jonckheere, Nicolas, Nuel, Grégory, Chevallier, Jean-Marc, Duboc, Henri, Rainteau, Dominique, Msika, Simon, Kapel, Nathalie, Couvelard, Anne, Bado, André, Le Gall, Maude, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes (UGA), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Service d'Anatomopathologie [Bichat - Claude Bernard], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra [Barcelona] (UPF), Laboratoire de Probabilités, Statistiques et Modélisations (LPSM (UMR_8001)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU Louis Mourrier, Microorganismes, Molécules Bioactives et Physiopathologie Intestinale (LBM-E4), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Ecosystème intestinal, probiotiques, antibiotiques (EA 4065), Université Paris Descartes - Paris 5 (UPD5), Service d'Anatomo-Pathologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Lille Neurosciences & Cognition - U 1172 (LilNCog), and Laboratoire de Probabilités, Statistique et Modélisation (LPSM (UMR_8001))

Subjects
[SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

33. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

Author

Ye, Yuanchao, primary, Abu El Haija, Marwa, additional, Morgan, Donald A., additional, Guo, Deng, additional, Song, Yang, additional, Frank, Aaron, additional, Tian, Liping, additional, Riedl, Ruth A., additional, Burnett, Colin M.L., additional, Gao, Zhan, additional, Zhu, Zhiyong, additional, Shahi, Shailesh K., additional, Zarei, Kasra, additional, Couvelard, Anne, additional, Poté, Nicolas, additional, Ribeiro-Parenti, Lara, additional, Bado, André, additional, Noureddine, Lama, additional, Bellizzi, Andrew, additional, Kievit, Paul, additional, Mangalam, Ashutosh K., additional, Zingman, Leonid V., additional, Le Gall, Maude, additional, Grobe, Justin L., additional, Kaplan, Lee M., additional, Clegg, Deborah, additional, Rahmouni, Kamal, additional, and Mokadem, Mohamad, additional

Published
2020
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35. Auteurs

Author

Brunaud Laurent, Quilliot Didier, Abou-Mrad Abel, Alkhamis Ahmed, Baud Grégory, Becouarn Guillaume, Blanchard Claire, Caiazzo Robert, Carette Claire, Ciangura Cécile, Czernichow Sébastien, Dargent Jérôme, de Jong Audrey, Denis Margot, Fouquet Thibault, Genser Laurent, Greilsamer Tristan, Lespessailles Éric, Malgras Aurélie, M'Harzi Leila, Michot Niasha, Msika Simon, Nocca David, Nomine-Criqui Claire, Pattou François, Pourcher Guillaume, Rebibo Lionel, Reibel Nicolas, Ribeiro-Parenti Lara, Rives-Lange Claire, Robert Maud, Santoro Sergio, Siksik Jean-Michel, Silvestri Marta, Sirveaux Marie-Aude, Souche François-Régis, Thereaux Jérémie, Topart Philippe, Torcivia Adriana, Witkowski Pierrette, and Ziegler Olivier

Published
2019

40. Effect of gastric by-pass on dietary protein bioavailability and protein anabolism in rats

Author

Gaudichon, Claire, Tessier, Romain, Ribeiro-Parenti, Lara, Ouafa, Bruneau, Cavin, Jean-Baptiste, Khodorova, Nadezda, Bado, André, Tomé, Daniel, Le Gall, Maude, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), AgroParisTech-Institut National de la Recherche Agronomique (INRA), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

41. One-anastomosis Gastric Bypass (OAGB) in Rats

Author

Siebert, Matthieu A., primary, Chevallier, Jean-Marc, primary, D'Aurelle de Paladines, Diego, primary, Pottier, Yohann, primary, Msika, Simon, primary, Le Gall, Maude, primary, Bado, André, primary, and Ribeiro-Parenti, Lara, primary

Published
2018
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42. Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Author

Habib, Aida, primary, Chokr, Dina, additional, Wan, JingHong, additional, Hegde, Pushpa, additional, Mabire, Morgane, additional, Siebert, Matthieu, additional, Ribeiro-Parenti, Lara, additional, Le Gall, Maude, additional, Lettéron, Philippe, additional, Pilard, Nathalie, additional, Mansouri, Abdellah, additional, Brouillet, Arthur, additional, Tardelli, Matteo, additional, Weiss, Emmanuel, additional, Le Faouder, Pauline, additional, Guillou, Hervé, additional, Cravatt, Benjamin F, additional, Moreau, Richard, additional, Trauner, Michael, additional, and Lotersztajn, Sophie, additional

Published
2018
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43. Roux-en-Y Gastric-Bypass and sleeve gastrectomy induces specific shifts of the gut microbiota without altering the metabolism of bile acids in the intestinal lumen

Author

Duboc, Henri, primary, Nguyen, Caroline Chong, additional, Cavin, Jean-Baptiste, additional, Ribeiro-Parenti, Lara, additional, Jarry, Anne-Charlotte, additional, Rainteau, Dominique, additional, Humbert, Lydie, additional, Coffin, Benoit, additional, Le Gall, Maude, additional, Bado, André, additional, and Sokol, Harry, additional

Published
2018
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44. Effet du by-pass gastrique sur la biodisponibilité des protéines alimentaires et l’anabolisme protéique chez le rat

Author

Tessier, Romain, Ribeiro-Parenti, Lara, Ouafa, Bruneau, Cavin, Jean-Baptiste, Khodorova, Nadezda, Lan, Annaig, Bado, André, Tomé, Daniel, Le Gall, Maude, Gaudichon, Claire, Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, AgroParisTech-Institut National de la Recherche Agronomique (INRA), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

47. Differences in Alimentary Glucose 1 Absorption and Intestinal Disposal of Blood Glucose Following Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

Author

Cavin, Jean-Baptiste, Couvelard, Anne, Lebtahi, Rachida, Ducroc, Robert, Arapis, Konstantinos, Voitellier, Eglantine, Cluzeaud, Françoise, Gillard, Laura, Hourseau, Muriel, Mikail, Nidaa, Ribeiro-Parenti, Lara, Kapel, Nathalie, Marmuse, Jean-Pierre, Bado, André, Le Gall, Maude, Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Anatomopathologie [Bichat - Claude Bernard], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de Médecine Nucléaire [Paris 18eme], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Chirurgie Générale et Digestive [Hôpital Bichat - Claude Bernard, Paris], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), This work was supported by French minister of higher education and research, INSERM and University Paris Diderot., and LE GALL, Maude

Subjects
GIP, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, enteroendocrine cells, nutritional and metabolic diseases, intestinal adaptation, enterohormones, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience; Background & Aims: Bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), are the most effective approaches to resolve type 2 diabetes in obese individuals. Alimentary glucose absorption and intestinal disposal of blood glucose have not been directly compared between individuals or animals that underwent RYGB vs VSG. We evaluated in rats and humans how the gut epithelium adapts following surgery and the consequences on alimentary glucose absorption and intestinal disposal of blood glucose. Methods: Obese male rats underwent RYGB, VSG, or sham (control) surgeries. We collected intestine segments from all rats; we performed histologic analyses and measured levels of mRNAs encoding the sugar transporters SGLT1, GLUT1, GLUT2, GLUT3, GLUT4 and GLUT5. Glucose transport and consumption were assayed using ex vivo jejunal loops. Histologic analyses were also performed on Roux limb sections from patients who underwent RYGB, 1–5 years after surgery. Roux limb glucose consumption was assayed following surgery by positron emission and computed tomography imaging.Results: In rats and humans that underwent RYGB, the Roux limb became hyperplasic, with an increased number of incretin-producing cells, compared with the corresponding jejunal segment of controls. Furthermore, expression of sugar transporters and hypoxia-related genes increased and the non-intestinal glucose transporter GLUT1 appeared at the basolateral membrane of enterocytes. Ingested and circulating glucose was trapped within the intestinal epithelial cells of rats and humans that underwent RYGB. By contrast, there was no hyperplasia of the intestine after VSG, but the intestinal absorption of alimentary glucose was reduced and density of endocrine cells secreting glucagon-like peptide-1 (GLP1) increased. Conclusions: The intestine adapts differently to RYGB vs VSG. RYGB increases intestinal glucose disposal, whereas VSG delays glucose absorption; both contribute to observed improvements in glycemia.

Published
2015

48. Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver.

Author

Habib, Aida, Chokr, Dina, JingHong Wan, Hegde, Pushpa, Mabire, Morgane, Siebert, Matthieu, Ribeiro-Parenti, Lara, Le Gall, Maude, Lettéron, Philippe, Pilard, Nathalie, Mansouri, Abdellah, Brouillet, Arthur, Tardelli, Matteo, Weiss, Emmanuel, Le Faouder, Pauline, Guillou, Hervé, Cravatt, Benjamin F., Moreau, Richard, Trauner, Michael, and Lotersztajn, Sophie

Subjects
LIPASES, FATTY liver
Published
2019
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49. Intestinal plasticity in response to nutrition and gastrointestinal surgery.

Author

Gall, Maude Le, Thenet, Sophie, Aguanno, Doriane, Jarry, Anne-Charlotte, Genser, Laurent, Ribeiro-Parenti, Lara, Joly, Francisca, Ledoux, Séverine, Bado, André, and Beyec, Johanne Le

Subjects
EPITHELIAL cells, GASTROINTESTINAL surgery, INTESTINAL physiology, PREVENTION of malnutrition, PREVENTION of obesity, GASTROINTESTINAL system, CELL physiology, DIET, DIGESTION, INTESTINES, NUTRITION, BARIATRIC surgery, SHORT bowel syndrome, NUTRITIONAL status, ANATOMY
Abstract

The plasticity of a material corresponds to its capacity to change its feature under the effect of an external action. Intestinal plasticity could be defined as the ability of the intestine to modify its size or thickness and intestinal cells to modulate their absorption and secretion functions in response to external or internal cues/signals. This review will focus on intestinal adaptation mechanisms in response to diet and nutritional status. These physiological mechanisms allow a fine and rapid adaptation of the gut to promote absorption of ingested food, but they can also lead to obesity in response to overnutrition. This plasticity could thus become a therapeutic target to treat not only undernutrition but also obesity. How the intestine adapts in response to 2 types of surgical remodeling of the digestive tract—extensive bowel resection leading to intestinal failure and surgical treatment of pathological obesity (ie, bariatric surgeries)—will also be reviewed. [ABSTRACT FROM AUTHOR]

Published
2019
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