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15 results on '"Ribourtout, Bénédicte"'

1. The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11

Author

Lafage-Pochitaloff, Marina, Gerby, Bastien, Baccini, Véronique, Largeaud, Laetitia, Fregona, Vincent, Prade, Naïs, Juvin, Pierre-Yves, Jamrog, Laura, Bories, Pierre, Hébrard, Sylvie, Lagarde, Stéphanie, Mansat-De Mas, Véronique, Dovey, Oliver M., Yusa, Kosuke, Vassiliou, George S., Jansen, Joop H., Tekath, Tobias, Rombaut, David, Ameye, Geneviève, Barin, Carole, Bidet, Audrey, Boudjarane, John, Collonge-Rame, Marie-Agnès, Gervais, Carine, Ittel, Antoine, Lefebvre, Christine, Luquet, Isabelle, Michaux, Lucienne, Nadal, Nathalie, Poirel, Hélène A., Radford-Weiss, Isabelle, Ribourtout, Bénédicte, Richebourg, Steven, Struski, Stéphanie, Terré, Christine, Tigaud, Isabelle, Penther, Dominique, Eclache, Virginie, Fontenay, Michaela, Broccardo, Cyril, and Delabesse, Eric

Published
2022
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2. Quantitative chimerism in CD3-negative mononuclear cells predicts prognosis in acute myeloid leukemia patients after hematopoietic stem cell transplantation

Author

Bouvier, Anne, Riou, Jérémie, Thépot, Sylvain, Sutra Del Galy, Aurélien, François, Sylvie, Schmidt, Aline, Orvain, Corentin, Estienne, Marie-Hélène, Villate, Alban, Luque Paz, Damien, Cottin, Laurane, Ribourtout, Bénédicte, Beucher, Annaëlle, Delneste, Yves, Ifrah, Norbert, Ugo, Valérie, Hunault-Berger, Mathilde, and Blanchet, Odile

Published
2020
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4. Relationship between comorbidities, mutational profile, and outcome after intensive chemotherapy in patients older than 60 years with acute myeloid leukemia: Assessment of different risk scores

Author

Bachelot, Amélie, primary, Bouvier, Anne, additional, Riou, Jérémie, additional, Thepot, Sylvain, additional, Giltat, Aurélien, additional, Nunes Gomes, Christopher, additional, Paillassa, Jérôme, additional, Jouanneau‐Courville, Rébecca, additional, Renard, Maxime, additional, Beucher, Annaelle, additional, Cottin, Laurane, additional, Wiber, Margaux, additional, Ribourtout, Bénédicte, additional, Geneviève, Franck, additional, Luque Paz, Damien, additional, Tanguy‐Schmidt, Aline, additional, Ugo, Valérie, additional, Hunault‐Berger, Mathilde, additional, Blanchet, Odile, additional, and Orvain, Corentin, additional

Published
2023
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6. The presence of a chromosomal abnormality in cytopenia without dysplasia identifies a category of high‐risk clonal cytopenia of unknown significance.

Author

Brett, Victor‐Emmanuel, Lechevalier, Nicolas, Trimoreau, Franck, Dussiau, Charles, Dimicoli‐Salazar, Sophie, Coster, Lucie, Luquet, Isabelle, Nadal, Nathalie, Ribourtout, Bénédicte, Chapiro, Elise, Lefebvre, Christine, Tondeur, Sylvie, Balducci, Estelle, Nguyen‐Khac, Florence, Borie, Claire, Radford‐Weiss, Isabelle, Barin, Carole, Eclache, Virginie, Mansier, Olivier, and Bidet, Audrey

Published
2023
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8. Quantitative chimerism in CD3-negative mononuclear cells predicts prognosis in acute myeloid leukemia patients after hematopoietic stem cell transplantation

Author

Bouvier, Anne, primary, Riou, Jérémie, additional, Thépot, Sylvain, additional, Sutra Del Galy, Aurélien, additional, François, Sylvie, additional, Schmidt, Aline, additional, Orvain, Corentin, additional, Estienne, Marie-Hélène, additional, Villate, Alban, additional, Luque Paz, Damien, additional, Cottin, Laurane, additional, Ribourtout, Bénédicte, additional, Beucher, Annaëlle, additional, Delneste, Yves, additional, Ifrah, Norbert, additional, Ugo, Valérie, additional, Hunault-Berger, Mathilde, additional, and Blanchet, Odile, additional

Published
2019
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9. The CADM1tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11

Author

Lafage-Pochitaloff, Marina, Gerby, Bastien, Baccini, Véronique, Largeaud, Laetitia, Fregona, Vincent, Prade, Naïs, Juvin, Pierre-Yves, Jamrog, Laura, Bories, Pierre, Hébrard, Sylvie, Lagarde, Stéphanie, Mansat-De Mas, Véronique, Dovey, Oliver M., Yusa, Kosuke, Vassiliou, George S., Jansen, Joop H., Tekath, Tobias, Rombaut, David, Ameye, Geneviève, Barin, Carole, Bidet, Audrey, Boudjarane, John, Collonge-Rame, Marie-Agnès, Gervais, Carine, Ittel, Antoine, Lefebvre, Christine, Luquet, Isabelle, Michaux, Lucienne, Nadal, Nathalie, Poirel, Hélène A., Radford-Weiss, Isabelle, Ribourtout, Bénédicte, Richebourg, Steven, Struski, Stéphanie, Terré, Christine, Tigaud, Isabelle, Penther, Dominique, Eclache, Virginie, Fontenay, Michaela, Broccardo, Cyril, and Delabesse, Eric

Abstract

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis leading to peripheral cytopenias and in a substantial proportion of cases to acute myeloid leukemia. The deletion of the long arm of chromosome 11, del(11q), is a rare but recurrent clonal event in MDS. Here, we detail the largest series of 113 cases of MDS and myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) harboring a del(11q) analyzed at clinical, cytological, cytogenetic, and molecular levels. Female predominance, a survival prognosis similar to other MDS, a low monocyte count, and dysmegakaryopoiesis were the specific clinical and cytological features of del(11q) MDS. In most cases, del(11q) was isolated, primary and interstitial encompassing the 11q22-23 region containing ATM, KMT2A, and CBLgenes. The common deleted region at 11q23.2 is centered on an intergenic region between CADM1(also known as Tumor Suppressor in Lung Cancer 1) and NXPE2. CADM1was expressed in all myeloid cells analyzed in contrast to NXPE2. At the functional level, the deletion of Cadm1 in murine Lineage-Sca1+Kit+cells modifies the lymphoid-to-myeloid ratio in bone marrow, although not altering their multilineage hematopoietic reconstitution potential after syngenic transplantation. Together with the frequent simultaneous deletions of KMT2A, ATM, and CBLand mutations of ASXL1, SF3B1, and CBL, we show that CADM1may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies.

Published
2022
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10. Donor cell-derived acute promyelocytic leukemia after allogeneic hematopoietic stem cell transplantation

Author

Bouvier, Anne, primary, Ribourtout, Bénédicte, additional, François, Sylvie, additional, Orvain, Corentin, additional, Paz, Damien Luque, additional, Beucher, Annaëlle, additional, Guérard, Alexandre, additional, Guardiola, Philippe, additional, Ugo, Valérie, additional, Blanchet, Odile, additional, Geneviève, Franck, additional, Schmidt, Aline, additional, and Hunault-Berger, Mathilde, additional

Published
2018
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13. Acquired Pelger-Huët anomaly/abnormal chromatin clumping of granulocytes after allogeneic hematopoietic stem cell transplantation for acute myeloid leukaemia: medication or relapse?

Author

Daufresne, Pierre, additional, Cottin, Laurane, additional, Girard, Jean-Maxime, additional, Henriot, Iris, additional, Zharkova, Anna, additional, Sutra Del Galy, Aurélien, additional, Schmidt, Aline, additional, Ribourtout, Bénédicte, additional, and Zandecki, Marc, additional

Published
2016
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14. The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11

Author

Lafage-Pochitaloff, Marina, Gerby, Bastien, Baccini, Véronique, Largeaud, Laetitia, Fregona, Vincent, Prade, Naïs, Juvin, Pierre-Yves, Jamrog, Laura, Bories, Pierre, Hébrard, Sylvie, Lagarde, Stéphanie, Mansat-De Mas, Véronique, Dovey, Oliver M, Yusa, Kosuke, Vassiliou, George S, Jansen, Joop H, Tekath, Tobias, Rombaut, David, Ameye, Geneviève, Barin, Carole, Bidet, Audrey, Boudjarane, John, Collonge-Rame, Marie-Agnès, Gervais, Carine, Ittel, Antoine, Lefebvre, Christine, Luquet, Isabelle, Michaux, Lucienne, Nadal, Nathalie, Poirel, Hélène A, Radford-Weiss, Isabelle, Ribourtout, Bénédicte, Richebourg, Steven, Struski, Stéphanie, Terré, Christine, Tigaud, Isabelle, Penther, Dominique, Eclache, Virginie, Fontenay, Michaela, Broccardo, Cyril, and Delabesse, Eric

Subjects
Leukemia, Myeloid, Acute, Mice, hemic and lymphatic diseases, Chromosomes, Human, Pair 11, Myelodysplastic Syndromes, Cell Adhesion Molecule-1, Animals, Humans, Female, Genes, Tumor Suppressor, Chromosome Deletion, 3. Good health
Abstract

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis leading to peripheral cytopenias and in a substantial proportion of cases to acute myeloid leukemia. The deletion of the long arm of chromosome 11, del(11q), is a rare but recurrent clonal event in MDS. Here, we detail the largest series of 113 cases of MDS and myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) harboring a del(11q) analyzed at clinical, cytological, cytogenetic, and molecular levels. Female predominance, a survival prognosis similar to other MDS, a low monocyte count, and dysmegakaryopoiesis were the specific clinical and cytological features of del(11q) MDS. In most cases, del(11q) was isolated, primary and interstitial encompassing the 11q22-23 region containing ATM, KMT2A, and CBL genes. The common deleted region at 11q23.2 is centered on an intergenic region between CADM1 (also known as Tumor Suppressor in Lung Cancer 1) and NXPE2. CADM1 was expressed in all myeloid cells analyzed in contrast to NXPE2. At the functional level, the deletion of Cadm1 in murine Lineage-Sca1+Kit+ cells modifies the lymphoid-to-myeloid ratio in bone marrow, although not altering their multilineage hematopoietic reconstitution potential after syngenic transplantation. Together with the frequent simultaneous deletions of KMT2A, ATM, and CBL and mutations of ASXL1, SF3B1, and CBL, we show that CADM1 may be important in the physiopathology of the del(11q) MDS, extending its role as tumor-suppressor gene from solid tumors to hematopoietic malignancies.

15. Molecular landscape of mature B-cell lymphoproliferative disorders with BCL3-translocation: A Groupe Francophone de Cytogénétique Hématologique (GFCH)/French Innovative Leukemia Organization (FILO) study.

Author

Véronèse L, Bensaber H, Dannus LT, Giannone G, Choiset C, Grimpret C, Abermil N, Balducci E, Bidet A, Chapiro E, Couronné L, Daudignon A, Douet-Gilbert N, Eclache V, Gaillard B, Gaillard JB, Hsoumi F, Lefebvre C, Nadal N, Mozziconacci MJ, Penther D, Ribourtout B, Richebourg S, Rigollet L, Terre C, Soler G, Tournilhac O, Guièze R, Nguyen-Khac F, and Tchirkov A

Subjects
Humans, Male, Female, Middle Aged, Lymphoproliferative Disorders genetics, Lymphoproliferative Disorders diagnosis, Aged, B-Lymphocytes metabolism, B-Lymphocytes pathology, Adult, France, B-Cell Lymphoma 3 Protein, Translocation, Genetic
Published
2024
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