Search

Background and objective Alternative chemotherapy regimens, including cisplatin, carmustine, or other agents, have been shown to be effective; however, the use of carboplatin plus vincristine (C/V) has not been studied before. In this study, we aimed to determine the survival rates in patients treated with C/V, by comparing our findings with treatments based on temozolomide (TMZ), and to explore a possible relationship with the methylation status of the methylguanine methyltransferase (MGMT) promoter in patients with glioblastoma (GB). Methods A retrospective cohort study was conducted involving 45 surgically treated patients diagnosed with GB. Fresh tissue samples were examined by the DNA bisulfite conversion method to determine methylation status. After surgery, different chemotherapy regimens were employed as adjuvants. Follow-up of participants was performed as outpatients at three-month intervals to determine overall survival (OS), by comparing the use of TMZ versus C/V. Results MGMT promoter methylation status could only be determined in 35 samples; 20 patients received adjuvant chemotherapy, of which 14 were treated with C/V and six with TMZ-based schemes. The median OS (mOS) was eight months (range: 1-24 months). OS was 57.25% at six months, 48.7% at 12 months, and 28.5% at 24 months. In the TMZ group, an OS of 83% was observed at 24 months. In the C/V group, OS was 71.4% at six months, 57.1% at 12 months, and 35.7% at 24 months. Patients who did not receive adjuvant chemotherapy treatment had the lowest survival rates with an OS of 39.9% at six months, 26.6% at 12 months, and 19.9% ​​at 24 months. Conclusions Based on our findings, C/V offers an accessible and effective alternative treatment when the TMZ-based scheme is not accessible, providing higher rates of OS compared to patients without chemotherapy management. The methylation status of the MGMT promoter is a significant prognostic factor, resulting in higher survival rates among patients when it is methylated.

Background Microsurgical laboratory training remains the mainstay to acquire, improve, and perfect surgical abilities. Microvascular anastomotic techniques are of key importance for revascularization procedures, such as in giant cerebral aneurysms, skull base complex tumours, and symptomatic ischemic cerebrovascular diseases. Methods We show the techniques, materials, and experience performed in a microsurgical laboratory of a neurosurgical referral center in Mexico City. Results We describe the materials, non-specimen suture practices, specimen manipulation, and finally all the individual procedures we are capable to perform on live specimens. Conclusions The microsurgical laboratory is an indispensable tool for the acquisition of the so needed microsurgical skills in neurosurgery, having a very special emphasis in vascular neurosurgery.

Background Standard pterional approaches have largely been used as the first option for middle cerebral artery aneurysms. This approach presents several disadvantages when facing giant aneurysms: aneurysmatic neck cannot be adequately seen and perianeurysmatic architecture is not completely visualized, leading to inappropriate clipping techniques. Orbitocranial approaches have been described in anterior communicating aneurysms, but not in middle cerebral artery bifurcation ones. Methods In this report, we present the case of a patient with subarachnoid hemorrhage secondary to a middle cerebral artery bifurcation aneurysm rupture which was clipped using an orbitocranial approach. We describe the surgical technique step-by-step, present a clinical report, and discuss the advantages and utility of this procedure. Results This technique was performed successfully and uneventfully in our patient, and it proved to be a safe method of clipping these kind of aneurysms, providing adequate visualization for the surgeon and making it safer for the patient. Conclusions We consider the orbitocranial approach as an adequate alternative to the conventional pterional approach when facing giant aneurysms of the middle cerebral artery bifurcations as it offers a much better visualization of the aneurysmatic neck, as well as that of the perianeurysmatic architecture.

Background: The aim of the study was to describe the origin, course, and termination of frontal aslant tract (FAT) in the Mexican population of neurosurgical referral centers. Methods: From January 2018 to May 2019, we analyzed 50 magnetic resonance imaging (MRI) studies in diffusion tensor imaging sequences of patients of the National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez.” Five brains were fixed by the Klingler method and dissected in the neurosurgery laboratory of the Hospital Civil de Guadalajara to identify the origin, trajectory, and ending of the FAT. Results: FAT was identified in 100% of the MRI and brain dissections. The origin of the FAT was observed in 63% from the supplementary premotor area, 24% from the supplementary motor area, and 13% in both areas. Its ending was observed in the pars opercularis in 81%, pars triangularis in 9%, and in both pars opercularis and ventral premotor area in 10% in the magnetic resonance images, with a left side predominance. In the hemispheres dissections, the origin of FAT was identified in 60% from the supplementary premotor area, 20% from the supplementary motor area, and 20% in both areas. Its ending was observed in the pars opercularis in 80% and the pars triangularis in 20%. It was not identified as an individual fascicle connected with the contralateral FAT. Conclusion: In the Mexican population, FAT has a left predominance; it is originated more frequently in the supplementary premotor area, passes dorsal to the superior longitudinal fascicle II and the superior periinsular sulcus, and ends more commonly in the pars opercularis.