Author: "Riccardi, Antonella" - Searchworks@Jio Institute Digital Library Search Results

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105 results on '"Riccardi, Antonella"'

1. Sex-specific risk of anti-topoisomerase antibodies on mortality and disease severity in systemic sclerosis: 10-year analysis of the Leiden CCISS and EUSTAR cohorts

Author: Liem, Sophie I E, Boonstra, Maaike, le Cessie, Saskia, Riccardi, Antonella, Airo, Paolo, Distler, Oliver, Matucci-Cerinic, Marco, Caimmi, Cristian, Siegert, Elise, Allanore, Yannick, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U, and de Vries-Bouwstra, Jeska K
Published: 2022
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2. Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early–early systemic sclerosis): a TDI study

Author: D’Alto, Michele, Riccardi, Antonella, Argiento, Paola, Di Stefano, Ilaria, Romeo, Emanuele, Iacono, Agostino Mattera, D’Andrea, Antonello, Fasano, Serena, Sanduzzi, Alessandro, Bocchino, Marialuisa, Docimo, Ludovico, Tolone, Salvatore, Russo, Maria Giovanna, and Valentini, Gabriele
Published: 2018
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3. Lung involvement in “stable” undifferentiated connective tissue diseases: a rheumatology perspective

Author: Riccardi, Antonella, Irace, Rosaria, Di Stefano, Ilaria, Iudici, Michele, Fasano, Serena, Bocchino, Marialuisa, Capaccio, Annalisa, Sanduzzi, Alessandro, and Valentini, Gabriele
Published: 2017
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4. CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)

Author: Valentini, Gabriele, Riccardi, Antonella, Vettori, Serena, Irace, Rosaria, Iudici, Michele, Tolone, Salvatore, Docimo, Ludovico, Bocchino, Marialuisa, Sanduzzi, Alessandro, and Cozzolino, Domenico
Published: 2017
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5. Serum CXCL4 increase in primary Sjögren’s syndrome characterizes patients with microvascular involvement and reduced salivary gland infiltration and lymph node involvement

Author: Vettori, Serena, Irace, Rosaria, Riccardi, Antonella, Iacono, Daniela, Pellecchia, Luciana, Vicedomini, Lucia, and Valentini, Gabriele
Published: 2016
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6. Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database

Author: Hoffmann-Vold, Anna-Maria, Allanore, Yannick, Alves, Margarida, Brunborg, Cathrine, Airó, Paolo, Ananieva, Lidia P, Czirják, László, Guiducci, Serena, Hachulla, Eric, Li, Mengtao, Mihai, Carina, Riemekasten, Gabriela, Sfikakis, Petros P, Kowal-Bielecka, Otylia, Riccardi, Antonella, Distler, Oliver, Smith, Vanessa, and on behalf of the EUSTAR consortium, [ missing ]
Subjects: Male, Vital capacity, Databases, Factual, Vital Capacity, Severity of Illness Index, Pulmonary function testing, 0302 clinical medicine, QUALITY-OF-LIFE, Risk Factors, Pulmonary fibrosis, Prevalence, Immunology and Allergy, FIBROSIS, scleroderma, Prospective Studies, 610 Medicine & health, PREDICTORS, Lung, Interstitial lung disease, respiratory system, Middle Aged, Dysphagia, Europe, Performing Arts, Cohort, Disease Progression, Female, medicine.symptom, Adult, medicine.medical_specialty, Immunology, Genetics and Molecular Biology, Systemic Sclerosis, behavioral disciplines and activities, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, FEV1/FVC ratio, Rheumatology, Internal medicine, medicine, Humans, COHORT, autoimmune diseases, 030203 arthritis & rheumatology, DECLINE, Scleroderma, Systemic, pulmonary fibrosis, business.industry, MORTALITY, PULMONARY-FUNCTION, systemic, medicine.disease, respiratory tract diseases, body regions, 030228 respiratory system, General Biochemistry, EULAR SCLERODERMA TRIALS, business, Lung Diseases, Interstitial, FORCED VITAL CAPACITY
Abstract: ObjectivesTo identify overall disease course, progression patterns and risk factors predictive for progressive interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials And Research (EUSTAR) database over long-term follow-up.MethodsEligible patients with SSc-ILD were registered in the EUSTAR database and had measurements of forced vital capacity (FVC) at baseline and after 12±3 months. Long-term progressive ILD and progression patterns were assessed in patients with multiple FVC measurements. Potential predictors of ILD progression were analysed using multivariable mixed-effect models.Results826 patients with SSc-ILD were included. Over 12±3 months, 219 (27%) showed progressive ILD: either moderate (FVC decline 5% to 10%) or significant (FVC decline >10%). A total of 535 (65%) patients had multiple FVC measurements available over mean 5-year follow-up. In each 12-month period, 23% to 27% of SSc-ILD patients showed progressive ILD, but only a minority of patients showed progression in consecutive periods. Most patients with progressive ILD (58%) had a pattern of slow lung function decline, with more periods of stability/improvement than decline, whereas only 8% showed rapid, continuously declining FVC; 178 (33%) experienced no episode of FVC decline. The strongest predictive factors for FVC decline over 5 years were male sex, higher modified Rodnan skin score and reflux/dysphagia symptoms.ConclusionSSc-ILD shows a heterogeneous and variable disease course, and thus monitoring all patients closely is important. Novel treatment concepts, with treatment initiation before FVC decline occurs, should aim for prevention of progression to avoid irreversible organ damage.
Published: 2020

7. Erosive arthritis autoantibodies in systemic sclerosis

Author: Riccardi, Antonella, primary, Martinroche, Guillaume, additional, Contin-Bordes, Cécile, additional, Avouac, Jérôme, additional, Gobeaux, Camille, additional, Cauvet, Anne, additional, Guerini, Henri, additional, Truchetet, Marie-Elise, additional, and Allanore, Yannick, additional
Published: 2022
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8. Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database

Author: Hoffmann-Vold, Anna-Maria, Allanore, Yannick, Alves, Margarida, Brunborg, Cathrine, Airó, Paolo, Ananieva, Lidia P, Czirják, László, Guiducci, Serena, Hachulla, Eric, Li, Mengtao, Mihai, Carina, Riemekasten, Gabriela, Sfikakis, Petros P, Kowal-Bielecka, Otylia, Riccardi, Antonella, Distler, Oliver, EUSTAR collaborators, University of Zurich, and Distler, Oliver
Subjects: 2403 Immunology, 1300 General Biochemistry, Genetics and Molecular Biology, 2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 2723 Immunology and Allergy, 610 Medicine & health
Published: 2021
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9. Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database

Author: Hoffmann-Vold, Anna-Maria; https://orcid.org/0000-0001-6467-7422, Allanore, Yannick; https://orcid.org/0000-0002-6149-0002, Alves, Margarida, Brunborg, Cathrine, Airó, Paolo, Ananieva, Lidia P, Czirják, László, Guiducci, Serena, Hachulla, Eric; https://orcid.org/0000-0001-7432-847X, Li, Mengtao; https://orcid.org/0000-0003-4252-2889, Mihai, Carina; https://orcid.org/0000-0002-8627-8817, Riemekasten, Gabriela, Sfikakis, Petros P; https://orcid.org/0000-0001-5484-2930, Kowal-Bielecka, Otylia, Riccardi, Antonella, Distler, Oliver; https://orcid.org/0000-0002-0546-8310, EUSTAR collaborators, Hoffmann-Vold, Anna-Maria; https://orcid.org/0000-0001-6467-7422, Allanore, Yannick; https://orcid.org/0000-0002-6149-0002, Alves, Margarida, Brunborg, Cathrine, Airó, Paolo, Ananieva, Lidia P, Czirják, László, Guiducci, Serena, Hachulla, Eric; https://orcid.org/0000-0001-7432-847X, Li, Mengtao; https://orcid.org/0000-0003-4252-2889, Mihai, Carina; https://orcid.org/0000-0002-8627-8817, Riemekasten, Gabriela, Sfikakis, Petros P; https://orcid.org/0000-0001-5484-2930, Kowal-Bielecka, Otylia, Riccardi, Antonella, Distler, Oliver; https://orcid.org/0000-0002-0546-8310, and EUSTAR collaborators
Abstract: OBJECTIVES: To identify overall disease course, progression patterns and risk factors predictive for progressive interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials And Research (EUSTAR) database over long-term follow-up. METHODS: Eligible patients with SSc-ILD were registered in the EUSTAR database and had measurements of forced vital capacity (FVC) at baseline and after 12±3 months. Long-term progressive ILD and progression patterns were assessed in patients with multiple FVC measurements. Potential predictors of ILD progression were analysed using multivariable mixed-effect models. RESULTS: 826 patients with SSc-ILD were included. Over 12±3 months, 219 (27%) showed progressive ILD: either moderate (FVC decline 5% to 10%) or significant (FVC decline >10%). A total of 535 (65%) patients had multiple FVC measurements available over mean 5-year follow-up. In each 12-month period, 23% to 27% of SSc-ILD patients showed progressive ILD, but only a minority of patients showed progression in consecutive periods. Most patients with progressive ILD (58%) had a pattern of slow lung function decline, with more periods of stability/improvement than decline, whereas only 8% showed rapid, continuously declining FVC; 178 (33%) experienced no episode of FVC decline. The strongest predictive factors for FVC decline over 5 years were male sex, higher modified Rodnan skin score and reflux/dysphagia symptoms. CONCLUSION: SSc-ILD shows a heterogeneous and variable disease course, and thus monitoring all patients closely is important. Novel treatment concepts, with treatment initiation before FVC decline occurs, should aim for prevention of progression to avoid irreversible organ damage.
Published: 2021

10. Reporting items for capillaroscopy in clinical research on musculoskeletal diseases: A systematic review and international Delphi consensus

Author: Immuno/reuma patientenzorg, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, Ingegnoli, Francesca, Herrick, Ariane L., Schioppo, Tommaso, Bartoli, Francesca, Ughi, Nicola, Pauling, John D., Sulli, Alberto, Cutolo, Maurizio, Smith, Vanessa, Akil, Mohammed, Ancuta, Codrina, Baines, Colin, Bernard, Imbert, Bhojani, Kaushik, Blaise, Sophie, Moscovici, Yolanda Braun, Caporali, Roberto, Chatelus, Emmanuel, Chatterjee, Soumya, Cracowski, Jean Luc, Csuka, Mary Ellen, Angelis, Rossella De, Vries-Bouwstra, Jeska De, Derk, Chris, Distler, Oliver, Duba, Ayyappa, Fernandez-Codina, Andreu, Foeldvari, Ivan, Frech, Tracy, Guerra, Miguel, Guiducci, Serena, Gyger, Geneviève, Hernandez-Molina, Gabriela, Hesselstrand, Roger, Hinze, Alicia, Hsu, Vivien, Hughes, Michael, Inanc, Murat, Irace, Rosaria, Jacobsen, Soren, Koenig, Martial, Lenaerts, Jan, Lwin, Cho Mar, Makol, Ashima, Martin, Thierry, Lopez, Maria Martin, Medina, Yimy F., Merkel, Peter A., Mesa Navas, Miguel Antonio, Messiniti, Valentina, Mihai, Carina, Nadashkevich, Oleg, Narain, Sonali, Lambova, Sevdalina Nikolova, Pelechas, Eleftherios, Pizzorni, Carmen, Riccardi, Antonella, Riccieri, Valeria, Rimar, Doron, Rudnicka, Lidia, Sabelli, Mirtha, Sarafrazi, Mojgan, Schonenberg-Meinema, Dieneke, Scolnik, Marina, Senécal, Jean Luc, Shenavandeh, Saeedeh, Sifuentes-Giraldo, Walter Alberto, Spierings, Julia, Stevens, Wendy, Valenzuela, Antonia, Velásquez-Franco, Carlos Jaime, Vila, Josephine, Vilela, Verônica, Vonk, Madelon, Voskuyl, Alexandre, Immuno/reuma patientenzorg, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, Ingegnoli, Francesca, Herrick, Ariane L., Schioppo, Tommaso, Bartoli, Francesca, Ughi, Nicola, Pauling, John D., Sulli, Alberto, Cutolo, Maurizio, Smith, Vanessa, Akil, Mohammed, Ancuta, Codrina, Baines, Colin, Bernard, Imbert, Bhojani, Kaushik, Blaise, Sophie, Moscovici, Yolanda Braun, Caporali, Roberto, Chatelus, Emmanuel, Chatterjee, Soumya, Cracowski, Jean Luc, Csuka, Mary Ellen, Angelis, Rossella De, Vries-Bouwstra, Jeska De, Derk, Chris, Distler, Oliver, Duba, Ayyappa, Fernandez-Codina, Andreu, Foeldvari, Ivan, Frech, Tracy, Guerra, Miguel, Guiducci, Serena, Gyger, Geneviève, Hernandez-Molina, Gabriela, Hesselstrand, Roger, Hinze, Alicia, Hsu, Vivien, Hughes, Michael, Inanc, Murat, Irace, Rosaria, Jacobsen, Soren, Koenig, Martial, Lenaerts, Jan, Lwin, Cho Mar, Makol, Ashima, Martin, Thierry, Lopez, Maria Martin, Medina, Yimy F., Merkel, Peter A., Mesa Navas, Miguel Antonio, Messiniti, Valentina, Mihai, Carina, Nadashkevich, Oleg, Narain, Sonali, Lambova, Sevdalina Nikolova, Pelechas, Eleftherios, Pizzorni, Carmen, Riccardi, Antonella, Riccieri, Valeria, Rimar, Doron, Rudnicka, Lidia, Sabelli, Mirtha, Sarafrazi, Mojgan, Schonenberg-Meinema, Dieneke, Scolnik, Marina, Senécal, Jean Luc, Shenavandeh, Saeedeh, Sifuentes-Giraldo, Walter Alberto, Spierings, Julia, Stevens, Wendy, Valenzuela, Antonia, Velásquez-Franco, Carlos Jaime, Vila, Josephine, Vilela, Verônica, Vonk, Madelon, and Voskuyl, Alexandre
Published: 2021

11. Undifferentiated connective tissue disease at risk for systemic sclerosis: Development of a short-term predictive score and a risk stratification tool

Author: Riccardi, Antonella, primary, Marcoccia, Antonella, additional, Modesti, Mariagrazia, additional, Bondanini, Francesco, additional, Irace, Rosaria, additional, Messiniti, Valentina, additional, Vitali, Claudio, additional, Del Papa, Nicoletta, additional, and Valentini, Gabriele, additional
Published: 2021
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12. Significant weight loss in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database

Author: Hughes, Michael, Heal, Calvin, Siegert, Elise, Hachulla, Eric, Airó, Paolo, Riccardi, Antonella, Distler, Oliver, Matucci-Cerinic, Marco, EUSTAR collaborators, University of Zurich, and Hughes, Michael
Subjects: 2403 Immunology, 1300 General Biochemistry, Genetics and Molecular Biology, 2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 2723 Immunology and Allergy, 610 Medicine & health
Published: 2020

13. The role of aspirin in the primary prevention of accelerated atherosclerosis in systemic autoimmune rheumatic diseases

Author: Fasano, Serena, primary, Iacono, Daniela, additional, Riccardi, Antonella, additional, Ciccia, Francesco, additional, and Valentini, Gabriele, additional
Published: 2020
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14. The Challenge of Very Early Systemic Sclerosis

Author: Riccardi, Antonella, primary, Marcoccia, Antonella, additional, and Valentini, Gabriele, additional
Published: 2020
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15. Significant weight loss in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database

Author: Hughes, Michael, primary, Heal, Calvin, additional, Siegert, Elise, additional, Hachulla, Eric, additional, Airó, Paolo, additional, Riccardi, Antonella, additional, Distler, Oliver, additional, and Matucci-Cerinic, Marco, additional
Published: 2020
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16. Biomarker panels may be superior over single molecules in prediction of renal flares in systemic lupus erythematosus: an exploratory study

Author: Fasano, Serena, primary, Pierro, Luciana, additional, Borgia, Alessia, additional, Coscia, Melania Alessia, additional, Formica, Ranieri, additional, Bucci, Laura, additional, Riccardi, Antonella, additional, and Ciccia, Francesco, additional
Published: 2020
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17. Vasodilators and low-dose acetylsalicylic acid are associated with a lower incidence of distinct primary myocardial disease manifestations in systemic sclerosis: results of the DeSScipher inception cohort study

Author: Valentini, Gabriele, Huscher, Dörte, Riccardi, Antonella, Fasano, Serena, Irace, Rosaria, Messiniti, Valentina, Matucci-Cerinic, Marco, Guiducci, Serena, Distler, Oliver, Maurer, Britta, Avouac, Jérôme, Tarner, Ingo H, Frerix, Marc, Riemekasten, Gabriela, Siegert, Elise, Czirják, László, Lóránd, Veronika, Denton, Christopher P, Nihtyanova, Svetlana, Walker, Ulrich A, Jaeger, Veronika K, Del Galdo, Francesco, Abignano, Giuseppina, Ananieva, Lidia P, Gherghe, Ana Maria, Mihai, Carina, Henes, Joerg Christoph, Schmeiser, Tim, Vacca, Alessandra, Moiseev, Sergey, et al, University of Zurich, and Valentini, Gabriele
Subjects: 2403 Immunology, 1300 General Biochemistry, Genetics and Molecular Biology, 2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 2723 Immunology and Allergy, 610 Medicine & health
Published: 2019

18. Hemodynamic changes after acute fluid loading in patients with systemic sclerosis without pulmonary hypertension

Author: D’Alto, Michele, Romeo, E., Argiento, P., Mattera Iacono, A., Vettori, Serena, Riccardi, Antonella, Allanore, Yannick, D’andrea, Antonello, Rea, Gaetano, Bossone, E., Valentini, Gabriele, Naeije, Robert, Golino, P., D’Alto, Michele, Romeo, E., Argiento, P., Mattera Iacono, A., Vettori, Serena, Riccardi, Antonella, Allanore, Yannick, D’andrea, Antonello, Rea, Gaetano, Bossone, E., Valentini, Gabriele, Naeije, Robert, and Golino, P.
Abstract: A fluid challenge with a rapid infusion of saline helps to discriminate between pre- and post-capillary pulmonary hypertension (PH) and allows unmasking hidden post-capillary PH. Systemic sclerosis (SSc) patients may present with biventricular systolic and diastolic dysfunction. The aim of this study was to evaluate the hemodynamic changes of the pulmonary circulation in SSc patients without PH after a fluid challenge. Twenty-five SSc patients and 25 controls underwent right heart catheterization in basal conditions and after volume loading with saline infusion of 7 mL/kg over 5–10 min. At baseline, there was no difference in hemodynamics between SSc patients and controls. Rapid volume loading resulted in a significant increase in pressures and flows in both groups. Increases in right atrial pressure (3 ± 1 vs. 2 ± 1 mmHg, P = 0.03), mean pulmonary artery pressure (5 ± 1 vs. 3 ± 1 mmHg, P < 0.001), and pulmonary artery wedge pressure (PAWP; 5 ± 2 vs. 3 ± 1 mmHg, P < 0.001) were larger in SSc patients than in controls. Conversely, cardiac index (0.4 ± 0.2 vs. 0.6 ± 0.3 L/min/m 2 ,P = 0.005) increased less in SSc patients than in controls. Pulmonary vascular resistance did not differ between groups before and after volume loading. Four SSc patients and only one of the controls reached a PAWP > 18 mmHg suggesting latent left heart failure. Even if differences are small and not diagnostic for heart failure, SSc patients without PH have a larger increase in pulmonary vascular pressures and a smaller increase in cardiac output than controls after an acute volume loading, probably due to subclinical left ventricular diastolic dysfunction., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2019

19. Undifferentiated connective tissue disease at risk of systemic sclerosis: A weighted score to identify patients who will evolve

Author: Riccardi, Antonella, primary, Marcoccia, Antonella, additional, Borgia, Alessia, additional, Guastafierro, Tiziana, additional, Bondanini, Francesco, additional, Fasano, Serena, additional, Irace, Rosaria, additional, Messiniti, Valentina, additional, Sanduzzi, Alessandro, additional, Bocchino, Marialuisa, additional, Ciani, Aldo, additional, D'Alto, Michele, additional, Argiento, Paola, additional, De Matteis, Giovanni Maria, additional, Spanò, Alberto, additional, and Valentini, Gabriele, additional
Published: 2019
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20. Revised European Scleroderma Trials and Research Group Activity Index is the best predictor of short-term severity accrual

Author: Fasano, Serena, primary, Riccardi, Antonella, additional, Messiniti, Valentina, additional, Caramaschi, Paola, additional, Rosato, Edoardo, additional, Maurer, Britta, additional, Smith, Vanessa, additional, Siegert, Elise, additional, De Langhe, Ellen, additional, Riccieri, Valeria, additional, Airó, Paolo, additional, Mihai, Carina, additional, Avouac, Jerome, additional, Zanatta, Elisabetta, additional, Walker, Ulrich A, additional, Iannone, Florenzo, additional, García De la Peña Lefebvre, Paloma, additional, Distler, Jörg H W, additional, Vacca, Alessandra, additional, Distler, Oliver, additional, Kowal-Bielecka, Otylia, additional, Allanore, Yannick, additional, and Valentini, Gabriele, additional
Published: 2019
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21. Vasodilators and low-dose acetylsalicylic acid are associated with a lower incidence of distinct primary myocardial disease manifestations in systemic sclerosis: results of the DeSScipher inception cohort study

Author: Valentini, Gabriele, primary, Huscher, Dörte, additional, Riccardi, Antonella, additional, Fasano, Serena, additional, Irace, Rosaria, additional, Messiniti, Valentina, additional, Matucci-Cerinic, Marco, additional, Guiducci, Serena, additional, Distler, Oliver, additional, Maurer, Britta, additional, Avouac, Jérôme, additional, Tarner, Ingo H, additional, Frerix, Marc, additional, Riemekasten, Gabriela, additional, Siegert, Elise, additional, Czirják, László, additional, Lóránd, Veronika, additional, Denton, Christopher P, additional, Nihtyanova, Svetlana, additional, Walker, Ulrich A, additional, Jaeger, Veronika K, additional, Del Galdo, Francesco, additional, Abignano, Giuseppina, additional, Ananieva, Lidia P, additional, Gherghe, Ana Maria, additional, Mihai, Carina, additional, Henes, Joerg Christoph, additional, Schmeiser, Tim, additional, Vacca, Alessandra, additional, Moiseev, Sergey, additional, Foeldvari, Ivan, additional, Gabrielli, Armando, additional, Krummel-Lorenz, Brigitte, additional, Rednic, Simona, additional, Allanore, Yannick, additional, and Müeller-Ladner, Ulf, additional
Published: 2019
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22. FRI0312 HYDROXYCHLOROQUINE SIGNIFICANTLY REDUCES SERUM MARKERS OF ENDOTHELIAL INJURY AND NEMO VIDEOCAPILLAROSCOPY SCORE IN SYSTEMIC SCLEROSIS: A 3-MONTHS PROSPECTIVE OBSERVATIONAL STUDY

Author: Basta, Fabio, primary, Irace, Rosaria, additional, Borgia, Alessia, additional, Messiniti, Valentina, additional, Riccardi, Antonella, additional, Valentini, Gabriele, additional, and Afeltra, Antonella, additional
Published: 2019
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23. THU0249 URINARY NEUTROPHIL GELATINASE ASSOCIATED LIPOCALCIN AND PROSTAGLANDIN D-SYNTHETASE PREDICT DISEASE FLARES IN SYSTEMIC LUPUS ERYTHEMATOSUS

Author: Fasano, Serena, primary, Pierro, Luciana, additional, Borgia, Alessia, additional, Coscia, Melania Alessia, additional, Formica, Ranieri, additional, Riccardi, Antonella, additional, and Ciccia, Francesco, additional
Published: 2019
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24. SAT0254 VASODILATOR THERAPY IN THE LONG TERM PREVENTION OF MYOCARDIAL MANIFESTATIONS IN SYSTEMIC SCLEROSIS (SSC): RESULTS FROM DESSCIPHER INCEPTION COHORT STUDY

Author: Riccardi, Antonella, primary, Husher, Dorte, additional, Fasano, Serena, additional, Messiniti, Valentina, additional, Allanore, Yannick, additional, Avouac, Jérôme, additional, Czirják, László, additional, Lorand, Veronika, additional, Galdo, Francesco Del, additional, Abignano, Giuseppina, additional, Denton, Christopher, additional, Nihtyanova, Svetlana, additional, Distler, Oliver, additional, Maurer, Britta, additional, Matucci-Cerinic, Marco, additional, Guiducci, Serena, additional, Riemekasten, Gabriela, additional, Siegert, Elise, additional, Walker, Ulrich, additional, Jaeger, Veronika, additional, Frerix, Marc, additional, Tarner, Ingo Helmut, additional, Müller-Ladner, Ulf, additional, and Valentini, Gabriele, additional
Published: 2019
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25. Hydroxychloroquine significantly reduces serum markers of endothelial injury and NEMO videocapillaroscopy score in systemic sclerosis

Author: Basta, Fabio, primary, Irace, Rosaria, additional, Borgia, Alessia, additional, Messiniti, Valentina, additional, Riccardi, Antonella, additional, Valentini, Gabriele, additional, and Afeltra, Antonella, additional
Published: 2019
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26. Hemodynamic changes after acute fluid loading in patients with systemic sclerosis without pulmonary hypertension

Author: D’Alto, Michele, primary, Romeo, Emanuele, additional, Argiento, Paola, additional, Mattera Iacono, Agostino, additional, Vettori, Serena, additional, Riccardi, Antonella, additional, Allanore, Yannick, additional, D’Andrea, Antonello, additional, Rea, Gaetano, additional, Bossone, Eduardo, additional, Valentini, Gabriele, additional, Naeije, Robert, additional, and Golino, Paolo, additional
Published: 2018
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27. Prolonged remission is associated with a reduced risk of cardiovascular disease in patients with systemic lupus erythematosus: a GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Author: Fasano, Serena, primary, Margiotta, Domenico Paolo Emanuele, additional, Pierro, Luciana, additional, Navarini, Luca, additional, Riccardi, Antonella, additional, Afeltra, Antonella, additional, and Valentini, Gabriele, additional
Published: 2018
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28. The incidence of cardiovascular events in Italian patients with systemic lupus erythematosus is lower than in North European and American cohorts

Author: Fasano, Serena, primary, Margiotta, Domenico Paolo, additional, Gualtierotti, Roberta, additional, Corrado, Ada, additional, Berardicurti, Onorina, additional, Iacono, Daniela, additional, Pierro, Luciana, additional, Riccardi, Antonella, additional, Giacomelli, Roberto, additional, Cantatore, Francesco Paolo, additional, Meroni, Pier Luigi, additional, Afeltra, Antonella, additional, and Valentini, Gabriele, additional
Published: 2018
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29. Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases

Author: Iudici,Michele, Irace,Rosaria, Riccardi,Antonella, Cuomo,Giovanna, Vettori,Serena, Valentini,Gabriele, Iudici,Michele, Irace,Rosaria, Riccardi,Antonella, Cuomo,Giovanna, Vettori,Serena, and Valentini,Gabriele
Abstract: Michele Iudici, Rosaria Irace, Antonella Riccardi, Giovanna Cuomo, Serena Vettori, Gabriele Valentini Rheumatology Section, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy Introduction/objectives: To prospectively assess the quality of life (QoL) of patients affected by undifferentiated connective tissue diseases (UCTDs) and to identify factors associated with changes over time.Patients and methods: A total of 46 consecutive UCTD patients completed the Short-Form 36 (SF-36) questionnaire at presentation and then yearly. At each 6-month visit, all patients underwent a detailed history taking and a laboratory and physical assessment, in order to follow the evolution of the disease over time and to assess the the co-existence of fibromyalgia.Results: At presentation, scores lower than the average of the general population were detected in 34 (74%) and 41 (89%) patients in the physical and mental domains, respectively. No difference between patients with and without Raynaud’s phenomenon was detected. Fibromyalgia was the only independent variable associated with an impaired physical component summary score (p = 0.0009). No patient feature was found to be associated with the basal mental component summary score. During 24 months of follow-up, a significant improvement (ie, a change ≥5 from baseline) in physical component summary and mental component summary scores was observed in 14 (33.3%) and 20 (43.4%) patients, respectively. Patients who significantly improved in the physical domain more frequently had a history of glucocorticoids intake (p < 0.001), while those who improved in the mental component more frequently had a history of either glucocorticoids (p = 0.043) or immunosuppressors (p = 0.037) intake during follow-up.Conclusion: UCTD patients perceive a worse QoL, regardless of Raynaud’s phenomenon Fibromy
Published: 2017

30. Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early–early systemic sclerosis): a TDI study

Author: D’Alto, Michele, primary, Riccardi, Antonella, additional, Argiento, Paola, additional, Di Stefano, Ilaria, additional, Romeo, Emanuele, additional, Iacono, Agostino Mattera, additional, D’Andrea, Antonello, additional, Fasano, Serena, additional, Sanduzzi, Alessandro, additional, Bocchino, Marialuisa, additional, Docimo, Ludovico, additional, Tolone, Salvatore, additional, Russo, Maria Giovanna, additional, and Valentini, Gabriele, additional
Published: 2017
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31. Undifferentiated connective tissue disease at risk for systemic sclerosis: is heart function already impaired?

Author: D'Alto, Michele, primary, Riccardi, Antonella, additional, Argiento, Paola, additional, Romeo, Emanuele, additional, De Stefano, Ilaria, additional, Mattera Iacono, Agostino, additional, Bocchino, Marialuisa, additional, Sanduzzi, Alessando, additional, Russo, Maria Giovanna, additional, and Valentini, Gabriele, additional
Published: 2017
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32. The cumulative number of micro-haemorrhages and micro-thromboses in nailfold videocapillaroscopy is a good indicator of disease activity in systemic sclerosis: a validation study of the NEMO score

Author: Andracco, Romina, primary, Irace, Rosaria, additional, Zaccara, Eleonora, additional, Vettori, Serena, additional, Maglione, Wanda, additional, Riccardi, Antonella, additional, Pignataro, Francesca, additional, Ferrara, Roberta, additional, Sambataro, Domenico, additional, Sambataro, Gianluca, additional, Vitali, Claudio, additional, Valentini, Gabriele, additional, and Del Papa, Nicoletta, additional
Published: 2017
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33. Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases

Author: Iudici, Michele, primary, Irace, Rosaria, additional, Riccardi, Antonella, additional, Cuomo, Giovanna, additional, Vettori, Serena, additional, and Valentini, Gabriele, additional
Published: 2017
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34. Prolonged remission is associated with a reduced risk of cardiovascular disease in patients with systemic lupus erythematosus: a GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study.

Author: Fasano, Serena, Margiotta, Domenico Paolo Emanuele, Pierro, Luciana, Navarini, Luca, Riccardi, Antonella, Afeltra, Antonella, and Valentini, Gabriele
Subjects: SYSTEMIC lupus erythematosus, LUPUS erythematosus, CARDIOVASCULAR diseases, LOG-rank test, MULTIVARIATE analysis
Abstract: Prolonged remission (PR), defined as a 5-year consecutive period of no disease activity based on SLEDAI-2K, has been reported to be associated with a lower damage accrual over time in patients with systemic lupus erythematosus (SLE), as the consequence of a lower activity burden. Since disease activity is considered to play a role in the incidence of cardiovascular disease (CVD), we investigated the relationship, if any, between PR and the occurrence of a subsequent first CV event in patients with SLE. Out of 488 patients consecutively admitted to two tertiary Italian centers from November 1, 2000, to December 31, 2016, the 294 patients, who had been followed at least for 5 years, had not experienced any CV event at admission, and had been visited biannually during follow-up, were considered for the present study. The incidence of a first CV in patients who had achieved PR was compared with that registered in those who had not. Moreover, it was compared among PR patients subdivided into three groups: complete remission, clinical off-corticosteroids (offCR), and clinical on-corticosteroids remission (onCR). Kaplan-Meier curves and the log-rank test were used to analyze differences in event-free survival among groups. Cox regression was used to investigate disease and therapeutic features associated with the development of a first CV event. During 9 years median follow-up time, 24 (8.1%) CV events occurred. Out of the 294 patients, 126 (42.8%) had achieved PR. Kaplan-Meier analysis revealed a greater overall CV event-free rate in these patients as compared to both those with a shorter lasting remission and those who had never remitted (log-rank test χ2 = 14.43; p = 0.0001). In addition, CV outcome did not differ among PR patients, irrespectively the type of remission achieved (p > 0.05). At multivariate analysis, hydroxychloroquine therapy and PR resulted to be protective (HR 0.19; HR 0.18), while arterial hypertension and antiphospholipid positivity increased the risk of a first CV event (HR 2.61; HR 2.47). The PR, whichever the subtype, is associated with a better CV outcome and should be considered as a treat-to-target goal in the CV risk management of the lupus patient. [ABSTRACT FROM AUTHOR]
Published: 2019
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35. CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)

Author: Valentini, Gabriele, primary, Riccardi, Antonella, additional, Vettori, Serena, additional, Irace, Rosaria, additional, Iudici, Michele, additional, Tolone, Salvatore, additional, Docimo, Ludovico, additional, Bocchino, Marialuisa, additional, Sanduzzi, Alessandro, additional, and Cozzolino, Domenico, additional
Published: 2016
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36. Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis. A tissue doppler imaging study

Author: D'Alto, Michele, primary, Argiento, Paola, additional, De Matteis, Giovanni Maria, additional, Marcoccia, Antonella, additional, Correra, Anna, additional, Romeo, Emanuele, additional, Di Marco, Giovanni Maria, additional, Irace, Rosaria, additional, Riccardi, Antonella, additional, Russo, Maria Giovanna, additional, and Valentini, Gabriele, additional
Published: 2016
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37. Racial differences in systemic sclerosis disease presentation: A European Scleroderma Trials and Research group study

Author: Jaeger, Veronika K, Tikly, Mohammed, Dong, Xu, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Mengtao, Li, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich, A, Randone, Sb, Bannert, B, Iannone, F, Maurer, B, Jordan, S, Dobrota, R, Becker, M, Mihai, C, Becvarare, R, Tomčík, M, Bielecka, Ok, Gindzienska-Sieskiewicz, E, Karaszewska, K, Cutolo, M, Pizzorni, C, Paolino, S, Sulli, A, Ruaro, B, Alessandri, E, Riccardi, A, Giacco, V, Messitini, V, Irace, R, Kedor, C, Casteleyn, V, Hilger, J, Hoeppner, J, Rednic, S, Szabo, I, Petcu, A, Avouac, J, Camelia, F, Desbas, C, Vlachoyiannopoulos, P, Montecucco, C, Caporali, R, Cavagna, L, Stork, J, Inanc, M, Joven, Be, Novak, S, Anic, F, Varju, C, Minier, T, Chizzolini, C, Allai, D, Kucharz, Ej, Kotulska, A, Kopec-Medrek, M, Widuchowska, M, Dolnicar, As, Coleiro, B, Gabrielli, A, Manfredi, L, Benfaremo, D, Ferrarini, A, Bancel, Df, Hij, A, Lansiaux, P, Lazzaroni, Mg, Hesselstrand, R, Wuttge, D, Andréasson, R, Martinovic, D, Bozic, I, Radic, M, Braun-Moscovici, Y, Monaco, Al, Furini, F, Hunzelmann, N, Moinzadeh, P, Pellerito, R, Caimmi, C, Bertoldo, E, Morovic-Vergles, J, Culo, Im, Pecher, Ac, Santamaria, Vo, Heitmann, S, Codagnone, M, Pflugfelder, J, Krasowska, D, Michalska-Jakubus, M, Seidel, M, Hasler, P, Kretschmar, S, Kohm, M, Bajocchi, G, Salvador, Mj, Silva, Japd, Stamenkovic, B, Stankovic, A, Selmi, Cf, Santis, M, Ceribelli, A, Garzanova, L, Koneva, O, Starovoytova, M, Herrick, A, Puppo, F, Negrini, S, Murdaca, G, Engelhart, M, Szücs, G, Szamosi, S, de la Puente, C, Grande, Cs, Villanueva, Mjg, Midtvedt, Sø, Hoffmann-Vold, Am, Launay, D, Sobanski, V, Riccieri, V, Vasile, M, Ionescu, Rm, Opris, D, Sha, A, Woods, A, Gheorghiu, Am, Bojinca, M, Sunderkötter, C, Ehrchen, J, Ingegnoli, F, Mouthon, L, Dunogue, B, Chaigne, B, Legendre, P, Cantatore, Fp, Corrado, A, Ullman, S, Iversen, L, von Mühlen CA, Pozzi, Mr, Eyerich, K, Lauffer, F, Wiland, P, Szmyrka-Kaczmarek, M, Sokolik, R, Morgiel, E, Madej, M, Vanthuyne, M, Frédéric, H, Alegre-Sancho, Jj, Aringer, M, Herrmann, K, Günther, C, Westhovens, R, Langhe, E, Lenaerts, J, Anic, B, Baresic, M, Mayer, M, Üprus, M, Otsa, K, Yavuz, S, Granel, B, Radominski, Sc, De, C, Müller, S, Azevedo, Vf, Mendoza, F, Busquets, J, Popa, S, Agachi, S, Zenone, T, Pileckyte, M, Stebbings, S, Mathieu, A, Vacca, A, Sampaio-Barros, Pd, Stamp, L, Solanki, K, Silva, C, Schollum, J, Barns-Graham, H, Veale, D, O'Rourke, M, Loyo, E, Tineo, C, Paulino, G, Mohamed, Waaa, Rosato, E, Gigante, A, Oksel, F, Yargucu, F, Tanaseanu, Cm, Popescu, M, Dumitrascu, A, Tiglea, I, Foti, R, Visalli, E, Benenati, A, Amato, G, Ancuta, C, Villiger, P, Adler, S, Fröhlich, J, Kayser, C, Eduardo, Al, Fathi, N, Alii, S, Ahmed, M, Hasaneen, S, Hakeem, Ee, de la PG, Lefebvre, P, Martin, Jjg, Sibilia, J, Chatelus, E, Gottenberg, Je, Chifflot, H, Litinsky, I, Galdo, Fd, Abignano, G, Eng, S, Seskute, G, Butrimiene, I, Rugiene, R, Karpec, D, Pascal, M, Kerzberg, E, Bianchi, W, Bianchi, Bv, Bianchi, Dv, Barcellos, Y, Castellví, I, Millan, M, Limonta, M, Rimar, D, Rosner, I, Slobodin, G, Couto, M, Spertini, F, Ribi, C, Buss, G, Marcoccia, A, Bondanini, F, Ciani, A, Kahl, S, Hsu, Vm, Martin, T, Poindron, V, Meghit, K, Moiseev, S, Novikov, P, Chung, L, Kolstad, K, Stark, M, Schmeiser, T, Thiele, A, Majewski, D, Zdrojewski, Z, Zaneta, S, Wierzba, K, Martínez-Barrio, J, López-Longo, Fj, Bernardino, V, Moraes-Fontes, Mf, Rodrigues, Ac, Riemekasten, G, Sommerlatte, S, Jendreck, S, Arnold, S, Levy, Y, Rezus, E, Cardoneanu, A, Burlui, Am, Pamuk, On, Puttini, Ps, Talotta, R, Bongiovanni, S, Poormoghim, H, Andalib, E, Almasi, S, Kötter, I, Krusche, M, Cuomo, G, Danzo, F, Masini, F, Gaches, F, Michaud, M, Cartos, F, Belloli, L, Casu, C, Sfikakis, P, Tektonidou, M, Furst, D, Feldman, Gr, Ramazan, Am, Nurmambet, E, Miroto, A, Suta, C, Andronache, I, Huizinga, Twj, de Vries-Bouwstra, J., Chizzolini, Carlo, Jaeger, Veronika K, Tikly, Mohammed, Xu, Dong, Siegert, Elise, Hachulla, Eric, Airò, Paolo, Valentini, Gabriele, Matucci Cerinic, Marco, Distler, Oliver, Cozzi, Franco, Carreira, Patricia, Allanore, Yannick, Müller-Ladner, Ulf, Ananieva, Lidia P, Balbir-Gurman, Alexandra, Distler, Jörg H W, Czirják, Laszlo, Li, Mengtao, Henes, Jörg, Jimenez, Sergio A, Smith, Vanessa, Damjanov, Nemanja, Denton, Christopher P, Delgaldo, Francesco, Saketkoo, Lesley Ann, Walker, Ulrich A, University of Zurich, Cerinic, Marco Matucci, Walker Ulrich, A, Randone, Silvia Bellando, Bannert, Bettina, Iannone, Florenzoaa, Maurer, Brittaab, Jordan, Suzanaab, Dobrota, Rucsandraab, Becker, Mikeab, Mihai, Carinaa, Becvarare, Radima, Tomcik, Michala, Bielecka, Otylia Kowala, Gindzienska-Sieskiewicz, Ewaa, Karaszewska, Katarzynaa, Cutolo, Maurizioa, Pizzorni, Carmena, Paolino, Sabrinaae, Sulli, Albertoa, Ruaro, Barbara, Alessandri, Elisa, Riccardi, Antonella, Giacco, Veronica, Messitini, Valentina, Irace, Rosaria, Kedor, Claudia, Casteleyn, Vincent, Hilger, Julia, Hoeppner, Jakob, Rednic, Simona, Szabo, Iulia, Petcu, Ana, Avouac, Jérome, Camelia, Frantz, Desbas, Carole, Vlachoyiannopoulos, Panayioti, Montecucco, Carlo Maurizio, Caporali, Roberto, Cavagna, Lorenzo, Stork, Jiri, Inanc, Murat, Joven, Beatriz E., Novak, Srdan, Anic, Felina, Varju, Cecilia, Minier, Tunde, Allai, Daniela, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Dolnicar, Alenka Sipek, Coleiro, Bernard, Gabrielli, Armando, Manfredi, Lucia, Benfaremo, Devi, Ferrarini, Alessia, Bancel, Dominique Farge, Hij, Adrian, Lazzaroni, Maria Grazia, Hesselstrand, Roger, Wuttge, Dirk, Andréasson, Kristofer, Martinovic, Duska, Bozic, Ivona, Radic, Mislav, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Furini, Federica, Hunzelmann, Nicola, Moinzadeh, Pia, Pellerito, Raffaele, Caimmi, Cristian, Bertoldo, Eugenia, Morovic-Vergles, Jadranka, Culo, Ivana Melanie, Pecher, Ann-Christian, Santamaria, Vera Ortiz, Heitmann, Stefan, Codagnone, Medeleine, Pflugfelder, Johanne, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthia, Hasler, Paul, Kretschmar, Samuel, Kohm, Michaela, Bajocchi, Gianluigi, Salvador, Maria João, Da Silva, JoséAntonio Pereira, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Ceribelli, Angela, Garzanova, Ludmila, Koneva, Olga, Starovoytova, Maya, Herrick, Ariane, Puppo, Francesco, Negrini, Simone, Murdaca, Giuseppe, Engelhart, Merete, Szücs, Gabriela, Szamosi, Szilvia, De La Puente, Carlo, Grande, Cristina Sobrino, Villanueva, Maria Jesus Garcia, Midtve, Øyvindbw, Hoffmann-Vold, Anna-Mariabw, Launay, Davidbx, Sobanski, Vincentbx, Riccieri, Valeriaby, Vasile, Massimilianoby, Stefantoni, Katia, Ionescu, Ruxandra Maria, Opris, Daniela, Sha, Ami, Woods, Adrianne, Gheorghiu, Ana Maria, Bojinca, Mihai, Sunderkötter, Cord, Ehrchen, Jan, Ingegnoli, Francesca, Mouthon, Luc, Dunogue, Bertrand, Chaigne, Benjamin, Legendre, Paul, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Von Mühlen, Carlos Alberto, Pozzi, Maria Rosa, Eyerich, Kilian, Lauffer, Felix, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Vanthuyne, Marie, Frédéric, Houssiau, Alegre-Sancho, Juan Jose, Aringer, Martin, Herrmann, Kristine, Günther, Claudia, Westhovens, Rene, De Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastião Cezar, De Souza Müller, Carolina, Feijóazevedo, Valderílio, Mendoza, Fabian, Busquets, Joanna, Popa, Sergei, Agachi, Svetlana, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Jordan, Sarah, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Stamp, Lisa, Solanki, Kamal, Silva, Cherumi, Schollum, Joanne, Barns-Graham, Helen, Veale, Dougla, O'Rourke, Marie, Loyo, Esthela, Tineo, Carmen, Paulino, Glenny, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Visalli, Elisa, Benenati, Alessia, Amato, Giorgio, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Fröhlich, Johanne, Kayser, Cristiane, Eduardo, Andrade Lui, Fathi, Nihal, Alii, Safa, Ahmed, Marrow, Hasaneen, Samar, El Hakeem, Eman, De La Peña Lefebvre, Paloma García, Martin, Jorge Juan Gonzalez, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Del Galdo, Francesco, Abignano, Giuseppina, Eng, Sookho, Seskute, Goda, Butrimiene, Irena, Rugiene, Rita, Karpec, Diana, Pascal, Melanie, Kerzberg, Eduardo, Bianchi, Washington, Bianchi, Breno Valdetaro, Bianchi, Dante Valdetaro, Barcellos, Yeda, Castellví, Ivan, Millan, Milena, Limonta, Massimiliano, Rimar, Doron, Rosner, Itzhak, Slobodin, Gleb, Couto, Maura, Spertini, Françoi, Ribi, Camillo, Buss, Guillaume, Marcoccia, Antonella, Bondanini, Francesco, Ciani, Aldo, Kahl, Sarah, Hsu, Vivien M., Martin, Thierry, Poindron, Vincent, Meghit, Kilifa, Moiseev, Sergey, Novikov, Pavel, Chung, Lori, Kolstad, Kathleen, Stark, Marianna, Schmeiser, Tim, Thiele, Astrid, Majewski, Dominik, Zdrojewski, Zbigniew, Zaneta, Smolenska, Wierzba, Karol, Martínez-Barrio, Julia, López-Longo, Francisco Javier, Bernardino, Vera, Moraes-Fontes, Maria Francisca, Rodrigues, Ana Catarina, Riemekasten, Gabriela, Sommerlatte, Sabine, Jendreck, Sebastian, Arnold, Sabrina, Levy, Yair, Rezus, Elena, Cardoneanu, Anca, Burlui, Alexandra Maria, Pamuk, Omer Nuri, Puttini, Piercarlo Sarzi, Talotta, Rossella, Bongiovanni, Sara, Poormoghim, Hadi, Andalib, Elham, Almasi, Simin, Kötter, Ina, Krusche, Matrin, Cuomo, Giovanna, Danzo, Fiammetta, Masini, Francesco, Gaches, Franci, Michaud, Martin, Cartos, Florian, Belloli, Laura, Casu, Cinzia, Sfikakis, Petro, Tektonidou, Maria, Furst, Daniel, Feldman, Gary R., Ramazan, Ana-Maria, Nurmambet, Emel, Miroto, Amalia, Suta, Cristina, Andronache, Iulia, Huizinga, Tom W. J., De Vries-Bouwstra, Jeska, and Walker, Ulrich A.
Subjects: Male, Vital capacity, Organ manifestations, systemic sclerosis, Type I, race difference, Systemic scleroderma, Gastroenterology, Scleroderma, immunology, 0302 clinical medicine, Diffusing capacity, middle aged, pulmonary hypertension, Medicine, Pharmacology (medical), 030212 general & internal medicine, organ manifestations, races, skin and connective tissue diseases, Lung, race, pathophysiology, African Continental Ancestry Group, ddc:616, integumentary system, disease course, Hazard ratio, Races, 10051 Rheumatology Clinic and Institute of Physical Medicine, Pulmonary, Middle Aged, Blacks, cohort analysis, Autoantibodie, 3. Good health, Asians, female, priority journal, DNA Topoisomerases, Type I, Black, centromere, Cohort, Hypertension, organ manifestation, Systemic sclerosis, Female, systemic sclerosi, Human, Adult, Asian Continental Ancestry Group, medicine.medical_specialty, Hypertension, Pulmonary, European Continental Ancestry Group, Black People, 610 Medicine & health, complication, Caucasian, White People, Article, lung, 03 medical and health sciences, Black person, Rheumatology, Asian People, forced vital capacity, Internal medicine, geographic distribution, Humans, controlled study, human, DNA topoisomerase, Aged, Autoantibodies, 030203 arthritis & rheumatology, Scleroderma, Systemic, Asian, business.industry, Whites, Systemic, Odds ratio, medicine.disease, Pulmonary hypertension, major clinical study, mortality, clinical feature, business, DNA Topoisomerases, autoantibody
Abstract: Objectives Racial factors play a significant role in SSc. We evaluated differences in SSc presentations between white patients (WP), Asian patients (AP) and black patients (BP) and analysed the effects of geographical locations. Methods SSc characteristics of patients from the EUSTAR cohort were cross-sectionally compared across racial groups using survival and multiple logistic regression analyses. Results The study included 9162 WP, 341 AP and 181 BP. AP developed the first non-RP feature faster than WP but slower than BP. AP were less frequently anti-centromere (ACA; odds ratio (OR) = 0.4, P < 0.001) and more frequently anti-topoisomerase-I autoantibodies (ATA) positive (OR = 1.2, P = 0.068), while BP were less likely to be ACA and ATA positive than were WP [OR(ACA) = 0.3, P < 0.001; OR(ATA) = 0.5, P = 0.020]. AP had less often (OR = 0.7, P = 0.06) and BP more often (OR = 2.7, P < 0.001) diffuse skin involvement than had WP. AP and BP were more likely to have pulmonary hypertension [OR(AP) = 2.6, P < 0.001; OR(BP) = 2.7, P = 0.03 vs WP] and a reduced forced vital capacity [OR(AP) = 2.5, P < 0.001; OR(BP) = 2.4, P < 0.004] than were WP. AP more often had an impaired diffusing capacity of the lung than had BP and WP [OR(AP vs BP) = 1.9, P = 0.038; OR(AP vs WP) = 2.4, P < 0.001]. After RP onset, AP and BP had a higher hazard to die than had WP [hazard ratio (HR) (AP) = 1.6, P = 0.011; HR(BP) = 2.1, P < 0.001]. Conclusion Compared with WP, and mostly independent of geographical location, AP have a faster and earlier disease onset with high prevalences of ATA, pulmonary hypertension and forced vital capacity impairment and higher mortality. BP had the fastest disease onset, a high prevalence of diffuse skin involvement and nominally the highest mortality.
Published: 2020

38. Significant weight loss in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database

Author: Michael Hughes, Calvin Heal, Elise Siegert, Eric Hachulla, Paolo Airó, Antonella Riccardi, Oliver Distler, Marco Matucci-Cerinic, Andrea Doria, Lorenzo Baretta, Alexandra Balbir-Gurman, Patricia E Carreira, Vanessa Smith, Carlos Alberto, Jörg Distler von Mühlen, Ulf Müller-Ladner, Lidia P Ananieva, László Czirják, Jörg Henes, Jeska de Vries-Bouwstra, Mengtao Li, Fabian Mendoza, Nemanja Damjanov, Ivan Castellví, Alessandro Giollo, Stefan Heitmann, Edoardo Rosato, Lorenzo Dagna, Christopher P Denton, Marie Vanthuyne, Fabio Cacciapaglia, Valeria Riccieri, Nicolas Hunzelmann, Ami Shah, Carlomaurizio Montecucco, Raffaele Pellerito, Ruxandra Maria Ionescu, Simona Rednic, Ulrich Walker, Maria Rosa Pozzi, Anna-Maria Hoffmann-Vold, Marie-Elise Truchetet, Susanne Ullman, Carolina de Souza Müller, Juan Jose Alegre-Sancho, Eduardo Kerzberg, Francesco Del Galdo, Gabriela Riemekasten, Branimir Anic, Marko Baresic, Miroslav Mayer, Fahrettin Oksel, Figen Yargucu, Ellen De Langhe, Ina Kötter, Mohammed Tikly, Radim Becvar, Douglas Veale, Dorota Krasowska, Andrea Lo Monaco, Lidia Rudnicka, Ana Maria Gheorghiu, Piercarlo Sarzi Puttini, Mislav Radic, Armando Gabrielli, Maria João Salvador, Carlos de la Puente, Gabriela Szücs, Sule Yavuz, Rosario Foti, Otylia Kowal Bielecka, Codrina Ancuta, Peter Villiger, Sabine Adler, Patrick Jego, Michaela Kohm, Eugene J Kucharz, Dominique Farge Bancel, Tim Schmeiser, Alberto Cauli, Alessandra Vacca, Kamal Solanki, Piotr Wiland, Paloma García de la Peña Lefebvre, Jorge Juan Gonzalez Martin, Sergio Jimenez, Lesley Ann Saketkoo, Roger Hesselstrand, Francesca Ingegnoli, Jean Sibilia, Merete Engelhart, Esthela Loyo, Carmen Tineo, Francesco Paolo Cantatore, Brigitte Krummel-Lorenz, Petros Sfikakis, Cristiane Kayser, Vera Ortiz Santamaria, Bojana Stamenkovic, Giovanna Cuomo, Francesco Puppo, Thierry Zenone, Nihal Fathi, Ira Litinsky, Carlo Chizzolini, Monika Swacha, Washington Bianchi, Breno Valdetaro Bianchi, Maria Üprus, Kati Otsa, Masataka Kuwana, Panayiotis Vlachoyiannopoulos, Sarah Kahl, Bernard Coleiro, François Spertini, Walid Ahmed Abdel Atty Mohamed, Sergey Moiseev, Pavel Novikov, Dominik Majewski, Simon Stebbings, Svetlana Agachi, Massimiliano Limonta, Carlo Francesco Selmi, Elena Rezus, Kristine Herrmann, Brigitte Granel, Goda Seskute, Matthias Seidel, Paul Hasler, Maurizio Cutolo Vera Bernardino, Carmen Pizzorni, Jadranka Morovic-Vergles, Daniel Furst, Ana-Maria Ramazan, Gianluigi Bajocchi, Lisa Stamp, Doron Rimar, Antonella Marcoccia, Srdan Novak, Luc Mouthon, Jiri Stork, Lorinda S Chung, Hadi Poormoghim, Francis Gaches, Laura Belloli, Cristina-Mihaela Tanaseanu, Fabiola Atzeni, Kilian Eyerich, Ivien M Hsu, Jacob van Laar, Mary Ellen Csuka, Omer Nuri Pamuk, Maura Couto, Arsene Mekinian, Murat Inanc, Ivan Foeldvari, Julia Martínez-Barrio, Yair Levy, Juliana Markus, Susana Oliveira, Hughes, Michael, Heal, Calvin, Siegert, Elise, Hachulla, Eric, Airó, Paolo, Riccardi, Antonella, Distler, Oliver, Matucci-Cerinic, Marco, Doria, Andrea, Baretta, Lorenzo, Balbir-Gurman, Alexandra, E Carreira, Patricia, Smith, Vanessa, Alberto, Carlo, Distler von Mühlen, Jörg, Müller-Ladner, Ulf, P Ananieva, Lidia, Czirják, László, Henes, Jörg, de Vries-Bouwstra, Jeska, Li, Mengtao, Mendoza, Fabian, Damjanov, Nemanja, Castellví, Ivan, Giollo, Alessandro, Heitmann, Stefan, Rosato, Edoardo, Dagna, Lorenzo, P Denton, Christopher, Vanthuyne, Marie, Cacciapaglia, Fabio, Riccieri, Valeria, Hunzelmann, Nicola, Shah, Ami, Montecucco, Carlomaurizio, Pellerito, Raffaele, Maria Ionescu, Ruxandra, Rednic, Simona, Walker, Ulrich, Rosa Pozzi, Maria, Hoffmann-Vold, Anna-Maria, Truchetet, Marie-Elise, Ullman, Susanne, de Souza Müller, Carolina, Jose Alegre-Sancho, Juan, Kerzberg, Eduardo, Del Galdo, Francesco, Riemekasten, Gabriela, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Oksel, Fahrettin, Yargucu, Figen, De Langhe, Ellen, Kötter, Ina, Tikly, Mohammed, Becvar, Radim, Veale, Dougla, Krasowska, Dorota, Lo Monaco, Andrea, Rudnicka, Lidia, Maria Gheorghiu, Ana, Sarzi Puttini, Piercarlo, Radic, Mislav, Gabrielli, Armando, João Salvador, Maria, de la Puente, Carlo, Szücs, Gabriela, Yavuz, Sule, Foti, Rosario, Kowal Bielecka, Otylia, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Jego, Patrick, Kohm, Michaela, J Kucharz, Eugene, Farge Bancel, Dominique, Schmeiser, Tim, Cauli, Alberto, Vacca, Alessandra, Solanki, Kamal, Wiland, Piotr, García de la Peña Lefebvre, Paloma, Juan Gonzalez Martin, Jorge, Jimenez, Sergio, Ann Saketkoo, Lesley, Hesselstrand, Roger, Ingegnoli, Francesca, Sibilia, Jean, Engelhart, Merete, Loyo, Esthela, Tineo, Carmen, Paolo Cantatore, Francesco, Krummel-Lorenz, Brigitte, Sfikakis, Petro, Kayser, Cristiane, Ortiz Santamaria, Vera, Stamenkovic, Bojana, Cuomo, Giovanna, Puppo, Francesco, Zenone, Thierry, Fathi, Nihal, Litinsky, Ira, Chizzolini, Carlo, Swacha, Monika, Bianchi, Washington, Valdetaro Bianchi, Breno, Üprus, Maria, Otsa, Kati, Kuwana, Masataka, Vlachoyiannopoulos, Panayioti, Kahl, Sarah, Coleiro, Bernard, Spertini, Françoi, Ahmed Abdel Atty Mohamed, Walid, Moiseev, Sergey, Novikov, Pavel, Majewski, Dominik, Stebbings, Simon, Agachi, Svetlana, Limonta, Massimiliano, Francesco Selmi, Carlo, Rezus, Elena, Herrmann, Kristine, Granel, Brigitte, Seskute, Goda, Seidel, Matthia, Hasler, Paul, Cutolo Vera Bernardino, Maurizio, Pizzorni, Carmen, Morovic-Vergles, Jadranka, Furst, Daniel, Ramazan, Ana-Maria, Bajocchi, Gianluigi, Stamp, Lisa, Rimar, Doron, Marcoccia, Antonella, Novak, Srdan, Mouthon, Luc, Stork, Jiri, S Chung, Lorinda, Poormoghim, Hadi, Gaches, Franci, Belloli, Laura, Tanaseanu, Cristina-Mihaela, Atzeni, Fabiola, Eyerich, Kilian, M Hsu, Ivien, van Laar, Jacob, Ellen Csuka, Mary, Nuri Pamuk, Omer, Couto, Maura, Mekinian, Arsene, Inanc, Murat, Foeldvari, Ivan, Martínez-Barrio, Julia, Levy, Yair, Markus, Juliana, and Oliveira, Susana
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, weight loss, systemic sclerosis, nutrition, Immunology, Disease, computer.software_genre, General Biochemistry, Genetics and Molecular Biology, Scleroderma, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Risk Factors, Weight loss, Internal medicine, Weight Loss, Epidemiology, medicine, Humans, Immunology and Allergy, 610 Medicine & health, Aged, 030203 arthritis & rheumatology, Scleroderma, Systemic, Database, business.industry, Middle Aged, medicine.disease, 030104 developmental biology, Mood, Databases as Topic, Female, Outcomes research, medicine.symptom, business, computer, Rheumatism
Abstract: Gastrointestinal (GI) involvement is almost universal in patients with systemic sclerosis (SSc) and is associated with significant disease-related morbidity and mortality.1 The entire GI tract can be involved and other disease features (eg, low mood, terminal organ failure and functional hand impairment) can result in significant nutritional impairment. Severe GI involvement has been reported to occur in ~10% of patients with SSc and often occurs early in the course of the disease.2 However, identification of patients at high risk of clinically significant weight loss is extremely challenging, including from the high prevalence of GI symptoms in patients with SSc. Therefore, there is a need to understand high-risk patients including potentially modifiable risk factors, with a view to early intervention strategies. Against this background, the aim of this study was to examine potential clinical risk factors of significant weight loss in patients with SSc. We performed an analysis of patients with SSc enrolled in the multinational, longitudinal European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) database. In our study, we defined significant weight loss as 4.5 kg and/or least 5% of their body weight at 5 months onwards.3 Patients with a recorded second visit after 3 months and before 12 months were included in the analysis. We adopted a pragmatic approach (relevant to clinical practice) in …
Published: 2020
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39. Biomarker panels may be superior over single molecules in prediction of renal flares in systemic lupus erythematosus: an exploratory study

Author: Melania Alessia Coscia, Antonella Riccardi, L. Pierro, Ranieri Formica, Laura Bucci, Francesco Ciccia, Serena Fasano, Alessia Borgia, Fasano, Serena, Pierro, Luciana, Borgia, Alessia, Coscia, Melania Alessia, Formica, Ranieri, Bucci, Laura, Riccardi, Antonella, and Ciccia, Francesco
Subjects: Adult, Male, medicine.medical_specialty, Urinary system, 030232 urology & nephrology, Lupus nephritis, Disease, lupus nephriti, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, systemic lupus erythematosus, Predictive Value of Tests, Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, Pharmacology (medical), Prospective Studies, 030203 arthritis & rheumatology, Kidney, Proportional hazards model, business.industry, Area under the curve, Middle Aged, medicine.disease, medicine.anatomical_structure, Mann–Whitney U test, Biomarker (medicine), biomarker, Female, Kidney Diseases, business, Biomarkers
Abstract: Objective Recent evidence suggests that some urinary biomarkers, namely Vascular Cell Adhesion Molecule-1 (VCAM-1), Intercellular Adhesion Molecule-1 (ICAM-1), Monocyte Chemoattractant Protein 1 (MCP-1), Neutrophil Gelatinase Associated Lipocalcin and Lipocalin-type Prostaglandin D-Synthetase (L-PGDS), might discriminate SLE patients with ongoing renal activity from those with stable disease. The objective of this study was to assess the role of these markers in predicting renal flares in comparison with conventional biomarkers and to derive a biomarker panel which may improve diagnostic accuracy. Methods Eligible participants were SLE patients prospectively followed at our clinic. Urinary biomarker levels were measured in urinary sample by ELISA assay and were compared by the unpaired Student’s t test or the Mann–Whitney U test as appropriate. Receiver operating characteristic analysis was used to calculate the area under the curve. Cox regression was used to identify independent factors associated with disease flares. Results Urine was collected from 61 patients. During 8 months’ follow-up, eight patients experienced a renal flare. Urinary L-PGDS, ICAM-1 and VCAM-1 levels were significantly increased in the patients who subsequently experienced a renal flare with respect to the remaining 53. At Cox regression analysis, L-PGDS, ICAM-1, VCAM-1, hypocomplementemia and anti-dsDNA antibodies were factors associated with renal flares. Based on receiver operating characteristic analysis, a combination of novel and conventional biomarkers demonstrated an excellent ability for accurately identifying a flare. Conclusion This study might suggest the usefulness of a novel biomarker panel in predicting a renal flare in SLE.
Published: 2020

40. Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early–early systemic sclerosis): a TDI study

Author: Emanuele Romeo, Ilaria Di Stefano, Maria Giovanna Russo, Salvatore Tolone, Ludovico Docimo, Antonello D'Andrea, Paola Argiento, Michele D'Alto, Marialuisa Bocchino, Antonella Riccardi, Gabriele Valentini, Alessandro Sanduzzi, Agostino Mattera Iacono, Serena Fasano, D’Alto, Michele, Riccardi, Antonella, Argiento, Paola, Di Stefano, Ilaria, Romeo, Emanuele, Iacono, Agostino Mattera, D’Andrea, Antonello, Fasano, Serena, Sanduzzi, Alessandro, Bocchino, Marialuisa, Docimo, Ludovico, Tolone, Salvatore, Russo, Maria Giovanna, Valentini, Gabriele, D'Alto, Michele, and D'Andrea, Antonello
Subjects: Adult, Male, medicine.medical_specialty, Pathology, Diastole, 030204 cardiovascular system & hematology, Doppler echocardiography, Doppler imaging, General Biochemistry, Genetics and Molecular Biology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cardiac involvement in SSc, Very early–early systemic sclerosi, Ventricular Dysfunction, medicine, Humans, Heart in UCTD-risk-SSc, Undifferentiated Connective Tissue Diseases, Young adult, Pulmonary wedge pressure, Aged, 030203 arthritis & rheumatology, Biochemistry, Genetics and Molecular Biology (all), Scleroderma, Systemic, medicine.diagnostic_test, business.industry, Undifferentiated connective tissue disease, Case-control study, Raynaud Disease, General Medicine, Middle Aged, medicine.disease, Echocardiography, Doppler, Pathophysiology, Undifferentiated Connective Tissue Disease, Case-Control Studies, Undifferentiated connective tissue disease at risk for systemic sclerosi, Cardiology, Female, Case-Control Studie, business, Human
Abstract: Undifferentiated connective tissue disease at risk for systemic sclerosis (UCTD-risk-SSc), otherwise referred to as very early-early SSc, is a condition characterized by Raynaud's phenomenon with serum SSc marker autoantibodies and/or typical capillaroscopic findings and unsatisfying classification criteria for the disease. The aim of the present study was to assess the prevalence of right (RV) or left ventricular (LV) systolic and/or diastolic dysfunction by standard echocardiography and tissue Doppler imaging (TDI). Thirty patients with UCTD-risk-SSc (28 female, mean age 47 ± 13 years, range 21-70) and 30 age- and sex-matched controls underwent cardiac assessment by standard echocardiography and TDI. UCTD-risk-SSc patients and controls did not show any difference at standard echocardiography. Despite results falling within the respective normal ranges, TDI pointed out a mild impairment of LV and RV diastolic (E m 15 ± 4 vs. 19 ± 5, p = 0.0004; E/E m 6.1 ± 1.7 vs. 4.8 ± 1.2, p = 0.001; E t 14 ± 3 vs. 16 ± 2, p = 0.02; E t/A t 0.9 ± 0.4 vs. 1.3 ± 0.3, p = 0.002; E/E t 3.5 ± 1.2 vs. 4.2 ± 0.9, p = 0.02) and systolic function (S m 13 ± 3 vs. 15 ± 2 cm/s, p
Published: 2017

41. Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases

Author: Serena Vettori, Antonella Riccardi, Gabriele Valentini, Michele Iudici, Giovanna Cuomo, Rosaria Irace, Iudici, Michele, Irace, Rosaria, Riccardi, Antonella, Cuomo, Giovanna, Vettori, Serena, and Valentini, Gabriele
Subjects: 0301 basic medicine, medicine.medical_specialty, Population, Disease, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, Quality of life, Fibromyalgia, Internal medicine, medicine, In patient, Medical history, education, Original Research, 030203 arthritis & rheumatology, education.field_of_study, glucocorticoids, business.industry, Undifferentiated connective tissue disease, medicine.disease, Patient Related Outcome Measures, undifferentiated connective tissue diseases, 030104 developmental biology, quality of life, glucocorticoid, fibromyalgia, business
Abstract: Michele Iudici, Rosaria Irace, Antonella Riccardi, Giovanna Cuomo, Serena Vettori, Gabriele Valentini Rheumatology Section, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy Introduction/objectives: To prospectively assess the quality of life (QoL) of patients affected by undifferentiated connective tissue diseases (UCTDs) and to identify factors associated with changes over time.Patients and methods: A total of 46 consecutive UCTD patients completed the Short-Form 36 (SF-36) questionnaire at presentation and then yearly. At each 6-month visit, all patients underwent a detailed history taking and a laboratory and physical assessment, in order to follow the evolution of the disease over time and to assess the the co-existence of fibromyalgia.Results: At presentation, scores lower than the average of the general population were detected in 34 (74%) and 41 (89%) patients in the physical and mental domains, respectively. No difference between patients with and without Raynaud’s phenomenon was detected. Fibromyalgia was the only independent variable associated with an impaired physical component summary score (p=0.0009). No patient feature was found to be associated with the basal mental component summary score. During 24months of follow-up, a significant improvement (ie, a change ≥5 from baseline) in physical component summary and mental component summary scores was observed in 14 (33.3%) and 20 (43.4%) patients, respectively. Patients who significantly improved in the physical domain more frequently had a history of glucocorticoids intake (p&nbsp
Published: 2017

42. Clinical features of patients with systemic lupus erythematosus according to health-related quality of life, entity of pain, fatigue and depression: a cluster analysis

Author: Domenico Paolo Emanuele, Margiotta, Serena, Fasano, Fabio, Basta, Luciana, Pierro, Antonella, Riccardi, Luca, Navarini, Gabriele, Valentini, Antonella, Afeltra, Margiotta, Domenico Paolo Emanuele, Fasano, Serena, Basta, Fabio, Pierro, Luciana, Riccardi, Antonella, Navarini, Luca, Valentini, Gabriele, and Afeltra, Antonella
Subjects: Depression, Surveys and Questionnaires, Quality of Life, Cluster Analysis, Humans, Lupus Erythematosus, Systemic, Pain, Female, Severity of Illness Index, Fatigue, Retrospective Studies
Abstract: To identify the distribution of patients with systemic lupus erythematosus (SLE) in clusters according to the levels of health-related quality of life (HRQoL), entity of pain, fatigue and depression.We performed a hierarchical cluster analysis. The following measures were used as clustering variables, after canonical transformation: the SF36 physical and mental component summary (PCS and MCS), the Beck Depression Inventory II (entity of depression), the Facit-Fatigue, all assessed during the last visit. Consecutive SLE patients were enrolled from two Italian cohorts. Lupus remission was retrospectively assessed over a period of 5 years before the last visit and was defined as a continuative period of no clinical disease activity according to SLEDAI2K and the maximum dose of prednisone allowed of 5 mg/day.We enrolled 130 female SLE patients. We identified three clusters. The first cluster (43 patients) was characterised by the highest levels of MCS and PCS and the lowest entity of pain, fatigue and depression. Cluster 2 (35 patients) was defined by a reduction of MCS and increase of pain, fatigue and depression; conversely, PCS levels were similar to cluster 1. In cluster 3 (52 patients) we found a reduction of MCS and increase of depression and fatigue (similar to cluster 2) but also a decrease in PCS levels and Bodily Pain (meaning increase in pain). In cluster 3 we found a decreased prevalence of remission ≥5 years.Identification of clusters of patients according to HRQoL levels could be useful to improve SLE management, aiming at personalised medicine.
Published: 2019

43. Prolonged remission is associated with a reduced risk of cardiovascular disease in patients with systemic lupus erythematosus: a GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Author: Domenico Paolo Emanuele Margiotta, Luca Navarini, Serena Fasano, Antonella Riccardi, L. Pierro, Antonella Afeltra, Gabriele Valentini, Fasano, Serena, Margiotta, Domenico Paolo Emanuele, Pierro, Luciana, Navarini, Luca, Riccardi, Antonella, Afeltra, Antonella, and Valentini, Gabriele
Subjects: Adult, Male, medicine.medical_specialty, Multivariate analysis, Remission, Kaplan-Meier Estimate, Disease, Systemic lupus erythematosu, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Adrenal Cortex Hormones, Risk Factors, Internal medicine, medicine, Humans, Lupus Erythematosus, Systemic, In patient, 030212 general & internal medicine, Retrospective Studies, 030203 arthritis & rheumatology, Systemic lupus erythematosus, Proportional hazards model, business.industry, Incidence, Incidence (epidemiology), Remission Induction, Hydroxychloroquine, General Medicine, Middle Aged, medicine.disease, Cardiovascular disease, Italy, Cardiovascular Diseases, Antirheumatic Agents, Multivariate Analysis, Antibodies, Antiphospholipid, Disease Progression, Female, business, medicine.drug
Abstract: Prolonged remission (PR), defined as a 5-year consecutive period of no disease activity based on SLEDAI-2K, has been reported to be associated with a lower damage accrual over time in patients with systemic lupus erythematosus (SLE), as the consequence of a lower activity burden. Since disease activity is considered to play a role in the incidence of cardiovascular disease (CVD), we investigated the relationship, if any, between PR and the occurrence of a subsequent first CV event in patients with SLE. Out of 488 patients consecutively admitted to two tertiary Italian centers from November 1, 2000, to December 31, 2016, the 294 patients, who had been followed at least for 5 years, had not experienced any CV event at admission, and had been visited biannually during follow-up, were considered for the present study. The incidence of a first CV in patients who had achieved PR was compared with that registered in those who had not. Moreover, it was compared among PR patients subdivided into three groups: complete remission, clinical off-corticosteroids (offCR), and clinical on-corticosteroids remission (onCR). Kaplan–Meier curves and the log-rank test were used to analyze differences in event-free survival among groups. Cox regression was used to investigate disease and therapeutic features associated with the development of a first CV event. During 9 years median follow-up time, 24 (8.1%) CV events occurred. Out of the 294 patients, 126 (42.8%) had achieved PR. Kaplan–Meier analysis revealed a greater overall CV event-free rate in these patients as compared to both those with a shorter lasting remission and those who had never remitted (log-rank test χ2 = 14.43; p = 0.0001). In addition, CV outcome did not differ among PR patients, irrespectively the type of remission achieved (p > 0.05). At multivariate analysis, hydroxychloroquine therapy and PR resulted to be protective (HR 0.19; HR 0.18), while arterial hypertension and antiphospholipid positivity increased the risk of a first CV event (HR 2.61; HR 2.47). The PR, whichever the subtype, is associated with a better CV outcome and should be considered as a treat-to-target goal in the CV risk management of the lupus patient.
Published: 2019

44. The incidence of cardiovascular events in Italian patients with systemic lupus erythematosus is lower than in North European and American cohorts: Implication of disease-associated and traditional risk factors as emerged by a 16-year retrospective GIRRCS study

Author: Domenico Paolo Emanuele Margiotta, L. Pierro, Antonella Riccardi, Roberto Giacomelli, Serena Fasano, Gabriele Valentini, Pier Luigi Meroni, Antonella Afeltra, Francesco Paolo Cantatore, Roberta Gualtierotti, Onorina Berardicurti, Daniela Iacono, Ada Corrado, Fasano, Serena, Margiotta, Domenico Paolo, Gualtierotti, Roberta, Corrado, Ada, Berardicurti, Onorina, Iacono, Daniela, Pierro, Luciana, Riccardi, Antonella, Giacomelli, Roberto, Cantatore, Francesco Paolo, Meroni, Pier Luigi, Afeltra, Antonella, and Valentini, Gabriele
Subjects: Adult, Male, Cardiovascular events, Incidence, Systemic lupus erythematosus, Environment, Female, Humans, Italy, Middle Aged, Patient Care Management, Retrospective Studies, Risk Factors, Cardiovascular Diseases, Lupus Erythematosus, Systemic, Medicine (all), medicine.medical_specialty, Observational Study, Disease, Cardiovascular event, Systemic lupus erythematosu, 030204 cardiovascular system & hematology, Observational period, 03 medical and health sciences, cardiovascular events, 0302 clinical medicine, systemic lupus erythematosus, Retrospective Studie, Internal medicine, Cardiovascular Disease, medicine, Cumulative incidence, 030203 arthritis & rheumatology, First episode, Lupus Erythematosus, business.industry, Incidence (epidemiology), Risk Factor, Systemic, Retrospective cohort study, General Medicine, medicine.disease, Cohort, business, Research Article, Human
Abstract: Previous study from our group has pointed out a lower number of cardiovascular (CV) events in Italian patients with systemic lupus erythematosus (SLE) than in North European and American ones. This study aims to assess the incidence of the first CV event in a large, multicenter, Italian cohort of patients with SLE and search for differences in disease and traditional risk factors among distinct cohorts. Clinical charts of SLE patients consecutively admitted to 5 Italian rheumatologic centers from November 1st 2000 to December 31st 2015 and free of CV events at baseline were retrospectively studied. CV cumulative incidence (ie, the proportion of patients who experienced a new CV event over the follow-up period) and CV incidence rate (ie, the number of events in the cohort divided by the total number of years at risk) were evaluated. The detected incidences were compared with those reported in SLE cohorts from other countries. The median duration of follow-up was 6 years (IQR=3-11). During the observational period, 37 (cumulative incidence=7.2%) patients had a first episode of CV event with an incidence rate of 10.1/1000 person-years. The CV cumulative incidence and incidence rate detected in our Italian cohort were lower than those from most North European and American cohorts, characterized by a high impact of traditional risk factors. Nevertheless, the cumulative incidence was similar to that reported in a Spanish cohort with a high frequency of traditional risk factors (geographic impact), while the incidence rate was only slightly higher than that in the Baltimore cohort, which is characterized by a strict follow-up of patients (medical impact). Our results confirmed that Italian lupus patients have a low incidence of CV events. Moreover, the geographic origin, traditional risk factors, and medical approach appear to have an impact on CV disease in SLE. Abbreviations: ACR = American College of Rheumatology, aPL = antiphospholipid antibody, ASA = aspirin, CV = cardiovascular, HCQ = hydroxychloroquine, SCORE = Systematic COronary Risk Evaluation, SLE = systemic lupus erythematosus.
Published: 2018

45. The cumulative number of micro-haemorrhages and micro-thromboses in nailfold videocapillaroscopy is a good indicator of disease activity in systemic sclerosis: A validation study of the NEMO score

Author: Wanda Maglione, Claudio Vitali, Nicoletta Del Papa, Francesca Pignataro, R. Andracco, Roberta Ferrara, Eleonora Zaccara, Gianluca Sambataro, Domenico Sambataro, Antonella Riccardi, Gabriele Valentini, Serena Vettori, Rosaria Irace, Andracco, Romina, Irace, Rosaria, Zaccara, Eleonora, Vettori, Serena, Maglione, Wanda, Riccardi, Antonella, Pignataro, Francesca, Ferrara, Roberta, Sambataro, Domenico, Sambataro, Gianluca, Vitali, Claudio, Valentini, Gabriele, and Del Papa, Nicoletta
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Validation study, lcsh:Diseases of the musculoskeletal system, Adolescent, Immunology, Nailfold videocapillaroscopy, Hemorrhage, Logistic regression, Microscopic Angioscopy, Cohort Studies, Fingers, Disease activity, Young Adult, 03 medical and health sciences, Systemic sclerosi, 0302 clinical medicine, Rheumatology, Internal medicine, medicine, Humans, Immunology and Allergy, In patient, skin and connective tissue diseases, Aged, Aged, 80 and over, 030203 arthritis & rheumatology, Scleroderma, Systemic, business.industry, Curve analysis, Reproducibility of Results, Thrombosis, Middle Aged, Surgery, 030104 developmental biology, Nails, Cohort, Systemic sclerosis, Female, lcsh:RC925-935, business, Research Article
Abstract: Background Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction in the number of capillaries (nCs), suggest a disease activity (DA) phase in systemic sclerosis (SSc). In a previous paper, we showed that the number of micro-haemorrhages and micro-thromboses (the so-called NEMO score) was the NVC feature more closely associated with DA. The present study was aimed at validating the NEMO score as a measure of DA in patients with SSc. Methods Two cohorts of 122 and 97 patients with SSc who were referred to two different rheumatology units, one in Milan and one in Naples, respectively, constituted the validation cohorts. The NEMO score, the total number of GCs and the mean nCs per digit were the parameters defined in each patient by eight-finger NVC. An expert operator analysed the NVCs in each of the participating units. The European Scleroderma Study Group (ESSG) index was used to define the DA level in each patient at the time of NVC examination. Results The NEMO score was the NVC parameter more strictly correlated with the ESSG score in both the Milan and Naples cohorts (p
Published: 2017

46. Lung involvement in 'stable' undifferentiated connective tissue diseases: a rheumatology perspective

Author: Michele Iudici, Annalisa Capaccio, Serena Fasano, Alessandro Sanduzzi, Rosaria Irace, Marialuisa Bocchino, Gabriele Valentini, Antonella Riccardi, Ilaria Di Stefano, Riccardi, Antonella, Irace, Rosaria, Di Stefano, Ilaria, Iudici, Michele, Fasano, Serena, Bocchino, Marialuisa, Capaccio, Annalisa, SANDUZZI ZAMPARELLI, Alessandro, Valentini, Gabriele, and Sanduzzi, Alessandro
Subjects: Adult, Male, medicine.medical_specialty, High-resolution computed tomography, Physical examination, Interstitial lung disease, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, DLCO, Internal medicine, Humans, Medicine, Undifferentiated connective tissue disease, Prospective Studies, Lung, 030203 arthritis & rheumatology, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, respiratory system, medicine.disease, Respiratory Function Tests, respiratory tract diseases, Lung high resolution computed tomography, medicine.anatomical_structure, 030228 respiratory system, Echocardiography, Antibodies, Antinuclear, Female, Undifferentiated connective tissue diseases, Radiology, medicine.symptom, Tomography, X-Ray Computed, business
Abstract: Previous studies of the occurrence of interstitial lung disease (ILD) in undifferentiated connective tissue diseases (UCTD) were conducted in patients admitted to Respiratory Medicine Units. The aim of the present prospective study was to investigate lung involvement in UCTD patients admitted to a Rheumatology Unit. Eighty-one consecutive UCTD patients were enrolled in the study. Each patient underwent history and physical examination, routine laboratory investigations, antinuclear antibody (ANA) profiling, B-mode echocardiography, and lung function study according to previously reported methods. Lung high resolution computed tomography (HRCT) was performed in patients who provided informed consent. Six patients (7.4%) had a history of grade II dyspnea. Three of them had a DLCO ranging from 42 to 55% of the predicted value; and a HRCT-documented ILD with a non-specific interstitial pneumonia (NSIP) pattern. Symptoms in the other three patients were due to cardiac disease. None of the 75 asymptomatic patients, had relevant findings at physical examination, 26/75 had a DLCO
Published: 2017

47. CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)

Author: Serena Vettori, Salvatore Tolone, Gabriele Valentini, Domenico Cozzolino, Alessandro Sanduzzi, Rosaria Irace, Antonella Riccardi, Marialuisa Bocchino, Michele Iudici, Ludovico Docimo, Valentini, Gabriele, Riccardi, Antonella, Vettori, Serena, Irace, Rosaria, Iudici, Michele, Tolone, Salvatore, Docimo, Ludovico, Bocchino, Marialuisa, Sanduzzi, Alessandro, Cozzolino, Domenico, and SANDUZZI ZAMPARELLI, Alessandro
Subjects: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Pathology, Disease duration, Platelet Factor 4, General Biochemistry, Genetics and Molecular Biology, Systemic sclerosi, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Undifferentiated connective tissue disease, In patient, Undifferentiated Connective Tissue Diseases, skin and connective tissue diseases, 030203 arthritis & rheumatology, Biochemistry, Genetics and Molecular Biology (all), Hematology, Scleroderma, Systemic, integumentary system, business.industry, Medicine (all), General Medicine, Middle Aged, medicine.disease, Prognosis, 030104 developmental biology, Female, business
Abstract: The aim of the study was to evaluate CXCL4 levels in undifferentiated connective tissue disease at risk for SSc (UCTD-SSc-risk) and confirm its increase and investigate its prognostic value. Serum CXCL4 levels were measured in 45 patients and 24 controls. CXCL4 was significantly higher in UCTD-SSc-risk patients than in controls. It resulted higher in patients with a shorter disease duration and in those lacking capillaroscopic alterations. We confirm that CXCL4 levels are increased in UCTD-risk-SSc patients. Further studies are needed to investigate the role of CXCL4 assessment in UCTD-risk-SSc.
Published: 2016

48. Serum CXCL4 increase in primary SjÃ¶gren’s syndrome characterizes patients with microvascular involvement and reduced salivary gland infiltration and lymph node involvement

Author: Lucia Vicedomini, Serena Vettori, Rosaria Irace, Gabriele Valentini, Antonella Riccardi, Daniela Iacono, Luciana Pellecchia, Vettori, Serena, Irace, Rosaria, Riccardi, Antonella, Iacono, Daniela, Pellecchia, Luciana, Vicedomini, Lucia, and Valentini, Gabriele
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Chemokine, Pathology, Raynaud’s phenomenon, Osteoarthritis, Platelet Factor 4, Gastroenterology, Salivary Glands, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, Humans, Medicine, Lymph node, SjÃ¶gren’s syndrome, Aged, Autoantibodies, 030203 arthritis & rheumatology, biology, Salivary gland, business.industry, Autoantibody, Raynaud Disease, General Medicine, CXCL4, Middle Aged, medicine.disease, Capillaries, Sjogren's Syndrome, 030104 developmental biology, medicine.anatomical_structure, biology.protein, sE-selectin, Female, Lymph Nodes, Antibody, business
Abstract: CXCL4 is an antiangiogenic and immunomodulatory chemokine. We aimed to investigate serum levels of CXCL4 in primary SjÃ¶gren’s syndrome (pSS), looking for associations with disease features. Thirty-nine consecutive pSS patients underwent clinical-serological assessment and nailfold videocapillaroscopy (NVC). Thirty-six patients and 30 controls affected by osteoarthritis were also investigated for serum levels of CXCL4 and soluble E-selectin (sE-selectin). CXCL4 was higher in pSS patients than in controls (1.79 [0.2–11.18] vs 1.023Â ng/ml [0.02–14.45], pÂ
Published: 2016

49. Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database.

Author: Hoffmann-Vold AM, Allanore Y, Alves M, Brunborg C, Airó P, Ananieva LP, Czirják L, Guiducci S, Hachulla E, Li M, Mihai C, Riemekasten G, Sfikakis PP, Kowal-Bielecka O, Riccardi A, and Distler O
Subjects: Adult, Databases, Factual, Disease Progression, Europe epidemiology, Female, Humans, Lung physiopathology, Lung Diseases, Interstitial etiology, Male, Middle Aged, Prevalence, Prospective Studies, Risk Factors, Scleroderma, Systemic complications, Vital Capacity, Lung Diseases, Interstitial epidemiology, Scleroderma, Systemic physiopathology, Severity of Illness Index
Abstract: Objectives: To identify overall disease course, progression patterns and risk factors predictive for progressive interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials And Research (EUSTAR) database over long-term follow-up., Methods: Eligible patients with SSc-ILD were registered in the EUSTAR database and had measurements of forced vital capacity (FVC) at baseline and after 12±3 months. Long-term progressive ILD and progression patterns were assessed in patients with multiple FVC measurements. Potential predictors of ILD progression were analysed using multivariable mixed-effect models., Results: 826 patients with SSc-ILD were included. Over 12±3 months, 219 (27%) showed progressive ILD: either moderate (FVC decline 5% to 10%) or significant (FVC decline >10%). A total of 535 (65%) patients had multiple FVC measurements available over mean 5-year follow-up. In each 12-month period, 23% to 27% of SSc-ILD patients showed progressive ILD, but only a minority of patients showed progression in consecutive periods. Most patients with progressive ILD (58%) had a pattern of slow lung function decline, with more periods of stability/improvement than decline, whereas only 8% showed rapid, continuously declining FVC; 178 (33%) experienced no episode of FVC decline. The strongest predictive factors for FVC decline over 5 years were male sex, higher modified Rodnan skin score and reflux/dysphagia symptoms., Conclusion: SSc-ILD shows a heterogeneous and variable disease course, and thus monitoring all patients closely is important. Novel treatment concepts, with treatment initiation before FVC decline occurs, should aim for prevention of progression to avoid irreversible organ damage., Competing Interests: Competing interests: A-MH-V received research funding and/or consulting fees or other remuneration from Actelion, Boehringer Ingelheim, Roche, Bayer, Thermo Fisher, MSD, Arxx and Medscape. YA received research funding and/or consulting fees from Actelion, Alpine, Bayer, BMS, Boehringer Ingelheim, Inventiva, Italfarmaco, Genentech Roche, Sanofi and Servier. MA is an employee of Boehringer Ingelheim. LA received consulting fees or other remuneration from Boehringer Ingelheim and Roche. LC received consulting fees from Actelion, Bayer, Boehringer Ingelheim, Medac, Pfizer and Roche. EH received research funding and/or consulting fees or other remuneration from Actelion, Bayer, GSK and Pfizer. CM received consulting fees or other remuneration from Actelion, Geneva, Roche and Rofarm. OK-B received consulting fees or other remuneration from Bayer, Boehringer Ingelheim, Inventiva, Medac, Novartis and Roche. OD received consulting fees and/or research funding from A.Menarini, Acceleron Pharma, Amgen, AnaMar, Bayer, Blade Therapeutics, Boehringer Ingelheim, Catenion, CSL Behring, ChemomAb, Ergonex, Glenmark Pharmaceuticals, GSK, Inventiva, Italfarmaco, iQone, IQVIA, Lilly, Medac, Medscape, Mitsubishi Tanabe Pharma, MSD, Novartis, Pfizer, Roche, Sanofi, Target Bioscience and UCB in the area of potential treatments of scleroderma and its complications, and holds Patent mir 29 for the treatment of systemic sclerosis (US8247389, EP2331143). CB, PA, SG, ML, GR, AR and PPS have no competing interests to disclose., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.)
Published: 2021
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50. Clinical features of patients with systemic lupus erythematosus according to health-related quality of life, entity of pain, fatigue and depression: a cluster analysis.

Author: Margiotta DPE, Fasano S, Basta F, Pierro L, Riccardi A, Navarini L, Valentini G, and Afeltra A
Subjects: Cluster Analysis, Female, Humans, Pain, Retrospective Studies, Severity of Illness Index, Surveys and Questionnaires, Depression epidemiology, Fatigue epidemiology, Lupus Erythematosus, Systemic, Quality of Life
Abstract: Objectives: To identify the distribution of patients with systemic lupus erythematosus (SLE) in clusters according to the levels of health-related quality of life (HRQoL), entity of pain, fatigue and depression., Methods: We performed a hierarchical cluster analysis. The following measures were used as clustering variables, after canonical transformation: the SF36 physical and mental component summary (PCS and MCS), the Beck Depression Inventory II (entity of depression), the Facit-Fatigue, all assessed during the last visit. Consecutive SLE patients were enrolled from two Italian cohorts. Lupus remission was retrospectively assessed over a period of 5 years before the last visit and was defined as a continuative period of no clinical disease activity according to SLEDAI2K and the maximum dose of prednisone allowed of 5 mg/day., Results: We enrolled 130 female SLE patients. We identified three clusters. The first cluster (43 patients) was characterised by the highest levels of MCS and PCS and the lowest entity of pain, fatigue and depression. Cluster 2 (35 patients) was defined by a reduction of MCS and increase of pain, fatigue and depression; conversely, PCS levels were similar to cluster 1. In cluster 3 (52 patients) we found a reduction of MCS and increase of depression and fatigue (similar to cluster 2) but also a decrease in PCS levels and Bodily Pain (meaning increase in pain). In cluster 3 we found a decreased prevalence of remission ≥5 years., Conclusions: Identification of clusters of patients according to HRQoL levels could be useful to improve SLE management, aiming at personalised medicine.
Published: 2019

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