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1. Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells

Author

Ascenzi, Francesca, Esposito, Antonella, Bruschini, Sara, Salvati, Valentina, De Vitis, Claudia, De Arcangelis, Valeria, Ricci, Giulia, Catizione, Angiolina, di Martino, Simona, Buglioni, Simonetta, Bassi, Massimiliano, Venuta, Federico, De Nicola, Francesca, Massacci, Alice, Grassucci, Isabella, Pallocca, Matteo, Ricci, Alberto, Fanciulli, Maurizio, Ciliberto, Gennaro, and Mancini, Rita

Published
2024
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3. ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis

Author

De Vitis, Claudia, Battaglia, Anna Martina, Pallocca, Matteo, Santamaria, Gianluca, Mimmi, Maria Chiara, Sacco, Alessandro, De Nicola, Francesca, Gaspari, Marco, Salvati, Valentina, Ascenzi, Francesca, Bruschini, Sara, Esposito, Antonella, Ricci, Giulia, Sperandio, Eleonora, Massacci, Alice, Prestagiacomo, Licia Elvira, Vecchione, Andrea, Ricci, Alberto, Sciacchitano, Salvatore, Salerno, Gerardo, French, Deborah, Aversa, Ilenia, Cereda, Cristina, Fanciulli, Maurizio, Chiaradonna, Ferdinando, Solito, Egle, Cuda, Giovanni, Costanzo, Francesco, Ciliberto, Gennaro, Mancini, Rita, and Biamonte, Flavia

Published
2023
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5. Triple Therapy in COPD in Real Life: Is It Better to Use Single or Multiple Inhalers?

Author

Sposato, Bruno, Ricci, Alberto, Lacerenza, Leonardo Gianluca, Petrucci, Elisa, Cresti, Alberto, Baratta, Pasquale, Perrella, Antonio, Serafini, Andrea, and Scalese, Marco

Subjects
*EMERGENCY room visits, *PATIENT compliance, *INHALERS, *MULTIVARIATE analysis, *ALBUTEROL
Abstract

Background: Today, single-inhaler ICS/LAMA/LABA (SITT) COPD therapies are available. It is unclear whether they are more effective than multiple-device triple therapies (MITT) in improving COPD outcomes. Methods: We retrospectively considered patients on SITT/MITT in 2019/2020 who were prescribed >7 packages of ICS/LABA/LAMA or ICS/LAMA (+LAMA). The two treatments were compared concerning systemic corticosteroids, antibiotics, salbutamol, antifungal prescriptions, and number of emergency room visits/hospitalizations (ERV/Hs). We studied 292 MITT patients (Group A) during 2019, switching to SITT in 2020, and 366 subjects (Group B) who took SITT during 2019, and 206 MITT individuals (Group C) in 2020. Results: ICS/LABA + LAMA (MITT) package use was 8.2 ± 4.2 and 7.85 ± 4 in 2019, switching to 11.2 ± 3.2 when patients shifted to SITT in 2020 (p = 0.0001). Group A MITT package use was lower than in SITT patients in 2019 (9.31 ± 2.71, p = 0.0001; Group B). Throughout 2020, Group C (10.3 ± 6.1 packs) adherence to ICS/LABA was similar to SITT adherence in Group A (p = 0.270), whereas LAMA package use (9.1 ± 5) was lower (p = 0.0038). Patients using systemic corticosteroids/antibiotics were fewer in SITT in 2020, compared to the MITT results in 2019. Subjects with fewer ERV/Hs were observed with SITT rather than with MITT. Particularly, 13.8% of patients needed ≥2 ERV/Hs when treated with SITT, whereas 19.2% needed ≥2 ERV/Hs with MITT in 2019 (p = 0.08). Multivariate analysis, adjusted for all confounding factors including treatment adherence, showed that MITT (vs. SITT) can have an increased risk of at least one ERV/H (subjects receiving MITT during 2019 passing to SITT in 2020, OR: 1.718 [1.010–2.924], p = 0.046; Group A/MITT/2019 vs. Group B/SITT/2019, OR: 1.650 [0.973–3.153], p = 0.056; Group C/MITT/2020 vs. Group B/SITT/2019, OR: 1.908 [1.018–3.577], p = 0.044). Conclusions: SITT therapy may promote treatment adherence more effectively, therefore, reducing COPD exacerbations better than MITT. A possible synergistic effect of ICS/LABA/LAMA intake with a single device might be another cause of SITT's greater efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Increased kynurenine-to-tryptophan ratio in the serum of patients infected with SARS-CoV2: An observational cohort study.

Author

Lionetto, Luana, Ulivieri, Martina, Capi, Matilde, De Bernardini, Donatella, Fazio, Francesco, Petrucca, Andrea, Pomes, Leda Marina, De Luca, Ottavia, Gentile, Giovanna, Casolla, Barbara, Curto, Martina, Salerno, Gerardo, Schillizzi, Serena, Torre, Maria Simona, Santino, Iolanda, Rocco, Monica, Marchetti, Paolo, Aceti, Antonio, Ricci, Alberto, Bonfini, Rita, Nicoletti, Ferdinando, Simmaco, Maurizio, and Borro, Marina

Published
2021
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9. TRITRIAL: The Impact of Fixed Triple Therapy with Beclometasone/Formoterol/Glycopyrronium on Health Status and Adherence in Chronic Obstructive Pulmonary Disease in an Italian Context of Real Life

Author

Richeldi,Luca, Schino,Pietro, Bargagli,Elena, Ricci,Alberto, Rocca,Alberto, Marchesani,Francesca, Pennisi,Alfio, Camiciottoli,Gianna, D'Amato,Maria, Macagno,Francesco, Scaffidi Argentina,Ulrica, Ingrassia,Eleonora, Piraino,Alessio, Richeldi,Luca, Schino,Pietro, Bargagli,Elena, Ricci,Alberto, Rocca,Alberto, Marchesani,Francesca, Pennisi,Alfio, Camiciottoli,Gianna, D'Amato,Maria, Macagno,Francesco, Scaffidi Argentina,Ulrica, Ingrassia,Eleonora, and Piraino,Alessio

Abstract

Luca Richeldi,1 Pietro Schino,2 Elena Bargagli,3 Alberto Ricci,4 Alberto Rocca,5 Francesca Marchesani,6 Alfio Pennisi,7 Gianna Camiciottoli,8,9 Maria D’Amato,10 Francesco Macagno,1 Ulrica Scaffidi Argentina,11 Eleonora Ingrassia,11 Alessio Piraino11 1Division of Pulmonary Medicine, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy; 2Miulli Hospital, Acquaviva Delle Fonti, Bari, Italy; 3Respiratory Diseases Unit, Department of Medical and Surgical Sciences, Neuro Sciences, Siena University Hospital, Siena, Italy; 4Department of Medical-Surgical Sciences and Translational Medicine, Via di Grottarossa 1035, Sapienza University of Rome, Rome, Italy; 5Department of Respiratory Medicine, Bellaria Hospital, Bologna, Italy; 6Division of Pneumology, Ospedale di Macerata, Macerata, Italy; 7Department of Respiratory Medicine, Hospital Clinic “Casa di Cura Riabilitativa Calaciura”, Catania, Italy; 8Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy; 9Department of Cardiothoracovascular, Careggi University Hospital, Firenze, Italy; 10UOSD Malattie Respiratorie ”Federico II”, Ospedale Monaldi, Napoli, 80131, Italy; 11Medical Affairs, Chiesi Italia S.p.A, Parma, ItalyCorrespondence: Ulrica Scaffidi Argentina, Chiesi Italia S.P.A, Via Giacomo Chiesi 1, Parma, 43122, Italy, Tel +39 0521 1689690 ; +39 346 82 61 074, Email u.scaffidiargentina@chiesi.comPurpose: The TRITRIAL study assessed the effects of beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) fixed combination in patients with chronic obstructive pulmonary disease (COPD) in a real-world setting, focusing on patient’s experience and perspective through the use of patients reported outcomes.Patients and Methods: TRITRIAL was a multicenter, prospective, observational study conducted on patients with moderate-severe C

Published
2024

10. TRITRIAL: The Impact of Fixed Triple Therapy with Beclometasone/Formoterol/Glycopyrronium on Health Status and Adherence in Chronic Obstructive Pulmonary Disease in an Italian Context of Real Life

Author

Richeldi, Luca, Schino, Pietro, Bargagli, Elena, Ricci, Alberto, Rocca, Alberto, Marchesani, Francesca, Pennisi, Alfio, Camiciottoli, Gianna, D'Amato, Maria, Macagno, Francesco, Scaffidi Argentina, Ulrica, Ingrassia, Eleonora, Piraino, Alessio, Richeldi, Luca (ORCID:0000-0001-8594-1448), Richeldi, Luca, Schino, Pietro, Bargagli, Elena, Ricci, Alberto, Rocca, Alberto, Marchesani, Francesca, Pennisi, Alfio, Camiciottoli, Gianna, D'Amato, Maria, Macagno, Francesco, Scaffidi Argentina, Ulrica, Ingrassia, Eleonora, Piraino, Alessio, and Richeldi, Luca (ORCID:0000-0001-8594-1448)

Abstract

Purpose: The TRITRIAL study assessed the effects of beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) fixed combination in patients with chronic obstructive pulmonary disease (COPD) in a real-world setting, focusing on patient's experience and perspective through the use of patients reported outcomes. Patients and methods: TRITRIAL was a multicenter, prospective, observational study conducted on patients with moderate-severe COPD treated with BDP/FF/G fixed therapy for 12 months. The main objective was to evaluate the impact of BDP/FF/G on health status through the COPD Assessment Test (CAT) score. Additional assessments included adherence and satisfaction, measured by the TAI-10/12 questionnaire and a specifically designed eight-item questionnaire, quality of life through the EQ-5D-5L test, sleep quality through the COPD and Asthma Sleep Impact Scale (CASIS), as well as safety and disease-related outcomes. Results: Data from 655 patients were analyzed in the study. The mean total CAT score significantly improved (from 22.8 at baseline to 18.1 at 6 months and 16.5 at 12 months; p < 0.0001), as well as all the eight CAT sub-items, which decreased on average by 0.5-0.9 points during the study. Adherence and usability of the inhaler also improved during the study, with a decrease in poor compliance (from 30.1% to 18.3%) and an increase in good compliance (from 51.8% to 58.3%) according to the TAI score. Patients also benefited from significantly improved quality of life (EQ Index from 0.70 to 0.80; EQ-5D VAS score from 55.1 to 63.1) and sleep quality (CASIS score from 41.1 to 31.8). Finally, patients reported a significant reduction in exacerbation during the study. Conclusion: TRITRIAL showed that the BDP/FF/G fixed combination is effective and safe in patients with moderate-severe COPD and poorly controlled disease, improving patients' HRQoL, sleep quality, adherence and inhaler usability and reducing COPD symptoms and the risk of exacerbati

Published
2024

12. Mepolizumab effectiveness on small airway obstruction, corticosteroid sparing and maintenance therapy step-down in real life

Author

Sposato, Bruno, Camiciottoli, Gianna, Bacci, Elena, Scalese, Marco, Carpagnano, Giovanna Elisiana, Pelaia, Corrado, Santus, Pierachille, Maniscalco, Mauro, Masieri, Simonetta, Corsico, Angelo, Scichilone, Nicola, Baglioni, Stefano, Murgia, Nicola, Folletti, Ilenia, Bardi, Giulio, Grosso, Amelia, Cameli, Paolo, Latorre, Manuela, Musarra, Antonino, Bargagli, Elena, Ricci, Alberto, Pelaia, Girolamo, Paggiaro, Pierluigi, and Rogliani, Paola

Published
2020
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13. TRITRIAL: The Impact of Fixed Triple Therapy with Beclometasone/Formoterol/Glycopyrronium on Health Status and Adherence in Chronic Obstructive Pulmonary Disease in an Italian Context of Real Life

Author

Richeldi, Luca, primary, Schino, Pietro, additional, Bargagli, Elena, additional, Ricci, Alberto, additional, Rocca, Alberto, additional, Marchesani, Francesca, additional, Pennisi, Alfio, additional, Camiciottoli, Gianna, additional, D'Amato, Maria, additional, Macagno, Francesco, additional, Scaffidi Argentina, Ulrica, additional, Ingrassia, Eleonora, additional, and Piraino, Alessio, additional

Published
2024
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15. Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies

Author

Sciacchitano, Salvatore, De Vitis, Claudia, D’Ascanio, Michela, Giovagnoli, Simonetta, De Dominicis, Chiara, Laghi, Andrea, Anibaldi, Paolo, Petrucca, Andrea, Salerno, Gerardo, Santino, Iolanda, Amodeo, Rachele, Simmaco, Maurizio, Napoli, Christian, Tafuri, Agostino, Di Napoli, Arianna, Sacconi, Andrea, Salvati, Valentina, Ciliberto, Gennaro, Fanciulli, Maurizio, Piaggio, Giulia, de Latouliere, Luisa, Ricci, Alberto, and Mancini, Rita

Published
2021
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17. Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients

Author

Sacconi, Andrea, De Vitis, Claudia, de Latouliere, Luisa, di Martino, Simona, De Nicola, Francesca, Goeman, Frauke, Mottini, Carla, Paolini, Francesca, D’Ascanio, Michela, Ricci, Alberto, Tafuri, Agostino, Marchetti, Paolo, Di Napoli, Arianna, De Biase, Luciano, Negro, Andrea, Napoli, Christian, Anibaldi, Paolo, Salvati, Valentina, Duffy, Darragh, Terrier, Benjamin, Fanciulli, Maurizio, Capalbo, Carlo, Sciacchitano, Salvatore, Blandino, Giovanni, Piaggio, Giulia, Mancini, Rita, and Ciliberto, Gennaro

Published
2021
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21. Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells

Author

Mancini, Rita, primary, Ascenzi, Francesca, additional, Esposito, Antonella, additional, Bruschini, Sara, additional, Salvati, Valentina, additional, De Vitis, Claudia, additional, Ricci, Giulia, additional, Martino, Simona Di, additional, Buglioni, Simonetta, additional, Bassi, Massimiliano, additional, Venuta, Federico, additional, De Nicola, Francesca, additional, Massacci, Alice, additional, Grassucci, Isabella, additional, Pallocca, Matteo, additional, Ricci, Alberto, additional, Fanciulli, Maurizio, additional, and Ciliberto, Gennaro, additional

Published
2023
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22. TRITRIAL study - TRIple Therapy in Real life: Impact on Adherence and HeaLth status in COPD patients in Italy.

Author

Richeldi, Luca, primary, Schino, Pietro, additional, Bargagli, Elena, additional, Ricci, Alberto, additional, Rocca, Alberto, additional, Marchesani, Francesca, additional, Pennisi, Alfio, additional, Camiciottoli, Gianna, additional, D'Amato, Mariella, additional, Macagno, Francesco, additional, Scaffidi Argentina, Ulrica, additional, Garavelli, Elena, additional, Ingrassia, Eleonora, additional, and Piraino, Alessio, additional

Published
2023
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23. The Impact of Extrafine Beclometasone/Formoterol/Glycopyrronium on Sleep disturbance in Chronic Obstructive Pulmonary Disease (COPD) in an Italian Context of Real Life: The TRITRIAL Study.

Author

Richeldi, Luca, primary, Schino, Pietro, additional, Bargagli, Elena, additional, Ricci, Alberto, additional, Rocca, Alberto, additional, Marchesani, Francesca, additional, Pennisi, Alfio, additional, Camiciottoli, Gianna, additional, D'Amato, Mariella, additional, Macagno, Francesco, additional, Scaffidi Argentina, Ulrica, additional, Garavelli, Elena, additional, Ingrassia, Eleonora, additional, and Piraino, Alessio, additional

Published
2023
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24. Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells

Author

Pisanu, Maria Elena, Noto, Alessia, De Vitis, Claudia, Morrone, Stefania, Scognamiglio, Giosuè, Botti, Gerardo, Venuta, Federico, Diso, Daniele, Jakopin, Ziga, Padula, Fabrizio, Ricci, Alberto, Mariotta, Salvatore, Giovagnoli, Maria Rosaria, Giarnieri, Enrico, Amelio, Ivano, Agostini, Massimiliano, Melino, Gerry, Ciliberto, Gennaro, and Mancini, Rita

Published
2017
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28. Short-Term Benefits of Smoking Cessation Improve Respiratory Function and Metabolism in Smokers

Author

Pezzuto,Aldo, Ricci,Alberto, D'Ascanio,Michela, Moretta,Alba, Tonini,Giuseppe, Calabrò,Noemi, Minoia,Valeria, Pacini,Alessia, De Paolis,Giuliana, Chichi,Eleonora, Carico,Elisabetta, Tammaro,Antonella, Pezzuto,Aldo, Ricci,Alberto, D'Ascanio,Michela, Moretta,Alba, Tonini,Giuseppe, Calabrò,Noemi, Minoia,Valeria, Pacini,Alessia, De Paolis,Giuliana, Chichi,Eleonora, Carico,Elisabetta, and Tammaro,Antonella

Abstract

Aldo Pezzuto,1 Alberto Ricci,1 Michela D’Ascanio,1 Alba Moretta,1 Giuseppe Tonini,2 Noemi Calabrò,1 Valeria Minoia,1 Alessia Pacini,1 Giuliana De Paolis,1 Eleonora Chichi,1 Elisabetta Carico,3 Antonella Tammaro4 1Department of Cardiovascular and Respiratory Sciences, S Andrea Hospital, Sapienza University, Rome, Italy; 2Oncology Department, Campus Bio-Medico University, Rome, Italy; 3Clinical and Molecular Medicine Department, S Andrea Hospital, Sapienza University, Rome, Italy; 4Department of Neuroscience- NESMOS, S.Andrea Hospital, Sapienza University, Rome, ItalyCorrespondence: Aldo Pezzuto, Email aldo.pezzuto@uniroma1.itBackground: Cigarette smoke exposure is the main preventable cause of chronic obstructive pulmonary disease (COPD). Airflow limitation is closely associated with smoking exposure. Smoking could also interfere with lipid metabolism.Aim: To determine the respiratory functional and metabolic changes after smoking cessation in smokers in the short term.Methods: All patients were current smokers. They were assessed by spirometry and questionnaires such as COPD assessment test(CAT), modified Medical Research Council (mMRC) test for dyspnea, Fagestrom’s test for nicotine dependence. Exhaled CO was detected in order to evaluate smoking exposure and smoking cessation (normal value< 7 ppm). A blood sampling was eventually taken for vitamin D and cholesterol assay. All patients underwent therapy with counselling and varenicline as first-line treatment according to its schedule. Detection time: at baseline and one month after smoking cessation.Results: All patients quit smoking during treatment. The mean age was 62 with a prevalence of males. The analysis revealed the following mean values at baseline: CAT mean score was 15, pack-years 35.5, Fagestrom’s Test mean score 5.0. The West’s value was 8.5, whereas Body mass index (BMI) was 25.5.Cigarette daily consumption mean value was 22.5. The comparison before and at follow up one month after smokin

Published
2023

33. Functional Benefit of Smoking Cessation and Triple Inhaler in Combustible Cigarette Smokers with Severe COPD: A Retrospective Study

Author

Pezzuto, Aldo, primary, Tonini, Giuseppe, additional, Ciccozzi, Massimo, additional, Crucitti, Pierfilippo, additional, D’Ascanio, Michela, additional, Cosci, Fiammetta, additional, Tammaro, Antonella, additional, Di Sotto, Antonella, additional, Palermo, Teresa, additional, Carico, Elisabetta, additional, and Ricci, Alberto, additional

Published
2022
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34. Selection Criteria and Treatment Outcome for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Unfit for Platinum-Based First-Line Therapy: Results of the MOON-OSS Observational Trial

Author

Camerini, Andrea, primary, Del Conte, Alessandro, additional, Pezzuto, Aldo, additional, Scotti, Vieri, additional, Facchinetti, Francesco, additional, Ciccone, Lucia Pia, additional, Perna, Marco, additional, Sartori, Giulia, additional, Puccetti, Cheti, additional, Ricci, Alberto, additional, Santo, Antonio, additional, Tiseo, Marcello, additional, and Amoroso, Domenico, additional

Published
2022
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35. B4GALT1 as a New Biomarker of Idiopathic Pulmonary Fibrosis

Author

De Vitis, Claudia, primary, D’Ascanio, Michela, additional, Sacconi, Andrea, additional, Pizzirusso, Dario, additional, Salvati, Valentina, additional, Mancini, Massimiliano, additional, Scafetta, Giorgia, additional, Cirombella, Roberto, additional, Ascenzi, Francesca, additional, Bruschini, Sara, additional, Esposito, Antonella, additional, Castelli, Silvia, additional, Salvucci, Claudia, additional, Teodonio, Leonardo, additional, Sposato, Bruno, additional, Catizone, Angela, additional, Di Napoli, Arianna, additional, Vecchione, Andrea, additional, Ciliberto, Gennaro, additional, Sciacchitano, Salvatore, additional, Ricci, Alberto, additional, and Mancini, Rita, additional

Published
2022
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36. Post-intubation tracheal lacerations: Risk-stratification and treatment protocol according to morphological classification

Author

Cardillo, Giuseppe, primary, Ricciardi, Sara, additional, Forcione, Anna Rita, additional, Carbone, Luigi, additional, Carleo, Francesco, additional, Di Martino, Marco, additional, Jaus, Massimo O., additional, Perdichizzi, Salvatore, additional, Scarci, Marco, additional, Ricci, Alberto, additional, Dello Iacono, Raffaele, additional, Lucantoni, Gabriele, additional, and Galluccio, Giovanni, additional

Published
2022
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37. ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis

Author

De Vitis, Claudia, primary, Battaglia, Anna Martina, additional, Pallocca, Matteo, additional, Santamaria, Gianluca, additional, Mimmi, Maria Chiara, additional, Sacco, Alessandro, additional, De Nicola, Francesca, additional, Gaspari, Marco, additional, Salvati, Valentina, additional, Ascenzi, Francesca, additional, Bruschini, Sara, additional, Esposito, Antonella, additional, Ricci, Giulia, additional, Sperandio, Eleonora, additional, Prestagiacomo, Licia Elvira, additional, Cavaliere, Rosy, additional, Vecchione, Andrea, additional, Ricci, Alberto, additional, Sciacchitano, Salvatore, additional, Salerno, Gerardo, additional, French, Deborah, additional, Aversa, Ilenia, additional, Cereda, Cristina, additional, Fanciulli, Maurizio, additional, Chiaradonna, Ferdinando, additional, Cuda, Giovanni, additional, Costanzo, Francesco, additional, Ciliberto, Gennaro, additional, Mancini, Rita, additional, and Biamonte, Flavia, additional

Published
2022
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40. Exogenous lipoid pneumonia induced by nasal decongestant

Author

Osman, Giorgia A., Ricci, Alberto, Terzo, Fabrizio, Falasca, Carlo, Giovagnoli, Maria R., Bruno, Pierdonato, Vecchione, Andrea, Raffa, Salvatore, Valente, Sabatino, Torrisi, Maria R., De Dominicis, Chiara, Giovagnoli, Simonetta, and Mariotta, Salvatore

Published
2018
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43. Road Toward a New Model of Care for Idiopathic Pulmonary Fibrosis in the Lazio Region

Author

Di Bidino, Rossella, primary, Rogliani, Paola, additional, Sebastiani, Alfredo, additional, Ricci, Alberto, additional, Varone, Francesco, additional, Sgalla, Giacomo, additional, Iovene, Bruno, additional, Bruni, Teresa, additional, Flore, Maria Chiara, additional, D'Ascanio, Michela, additional, Cavalli, Francesco, additional, Savi, Daniela, additional, Di Michele, Loreta, additional, Cicchetti, Americo, additional, and Richeldi, Luca, additional

Published
2022
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44. Predictors of respiratory failure after thoracic surgery: a retrospective cohort study with comparison between lobar and sub-lobar resection

Author

Pezzuto, Aldo, primary, Trabalza Marinucci, Beatrice, additional, Ricci, Alberto, additional, Ciccozzi, Massimo, additional, Tonini, Giuseppe, additional, D’Ascanio, Michela, additional, Guerrieri, Giulio, additional, Chianese, Maria, additional, Castelli, Silvia, additional, and Rendina, Erino Angelo, additional

Published
2022
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45. Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients

Author

Bruschini, Sara, primary, Pallocca, Matteo, additional, Sperandio, Eleonora, additional, D’Ambrosio, Lorenzo, additional, Ascenzi, Francesca, additional, De Vitis, Claudia, additional, Salvati, Valentina, additional, Esposito, Antonella, additional, Di Martino, Simona, additional, De Nicola, Francesca, additional, Paolini, Francesca, additional, Fattore, Luigi, additional, Alessandrini, Gabriele, additional, Facciolo, Francesco, additional, Foddai, Maria Laura, additional, Bassi, Massimiliano, additional, Venuta, Federico, additional, D’Ascanio, Michela, additional, Ricci, Alberto, additional, D’ Andrilli, Antonio, additional, Napoli, Christian, additional, Aurisicchio, Luigi, additional, Fanciulli, Maurizio, additional, Rendina, Erino Angelo, additional, Ciliberto, Gennaro, additional, and Mancini, Rita, additional

Published
2022
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50. Functional Benefit of Smoking Cessation and Triple Inhaler in Combustible Cigarette Smokers with Severe COPD: A Retrospective Study.

Author

Pezzuto, Aldo, Tonini, Giuseppe, Ciccozzi, Massimo, Crucitti, Pierfilippo, D'Ascanio, Michela, Cosci, Fiammetta, Tammaro, Antonella, Di Sotto, Antonella, Palermo, Teresa, Carico, Elisabetta, and Ricci, Alberto

Subjects
SMOKING cessation, CIGARETTE smokers, INHALERS, CHRONIC obstructive pulmonary disease
Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is the third cause of mortality and it is smoking-related. It is characterized by a non-reversible airflow limitation and a progressive worsening of the respiratory function. Objective: The aim of this study is to point out the benefit of smoking cessation combined with a single inhaler triple therapy in terms of clinical and functional outcome in this setting. Methods: A retrospective analysis was performed in patients affected by severe COPD and at least one exacerbation a year, who underwent a smoking cessation program. All patients underwent a 6 min walking test, body plethysmography, and an exhaled test for carbon monoxide. The modified medical research council test (mMRC) test, the Fagestrom nicotine dependency test (FTND) and the COPD assessment test (CAT) questionnaire were also administered. All patients were checked at the baseline and in the six-month follow-up after the start of the treatment. Results: Smoking cessation was achieved by 51% of patients within a month and it was confirmed by eCO measure (<7 ppm). Patients who quit smoking reported better results after six months compared with patients who did not. The increase in FEV1 within the group of quitters was 90 mL (p < 0.05) and the walking test improved by 90 m (p < 0.01); eCO decreased by 15 ppm (p < 0.01) while FVC increased by 70 mL (p < 0.05). No significant changes were recorded within the group of sustainers. The difference in functional changes between groups was significant with regard to FEV1, cCO, and WT. Conclusions: Smoking cessation enhances the efficacy of single inhaler triple therapy, improving clinical and functional variables after six months from the start. [ABSTRACT FROM AUTHOR]

Published
2023
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