371 results on '"Rice, Alexandra"'
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2. Exploring online reproductive health promotion in Canada: a focus on behavioral and environmental influences from a sex and gender perspective
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Rice, Alexandra R., Durowaye, Toluwanimi D., Konkle, Anne T. M., and Phillips, Karen P.
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- 2024
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3. Cardiac transplant rejection assessment with 18F-FDG PET-CT: initial single-centre experience for diagnosis and management
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Dar, Owais, Dulay, Mansimran Singh, Riesgo-Gil, Fernando, Morley-Smith, Andrew, Brookes, Paul, Lyster, Haifa, Rice, Alexandra, Underwood, Stephen R., Dunning, John, and Wechalekar, Kshama
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- 2024
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4. Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis
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Hewitt, Richard J., Puttur, Franz, Gaboriau, David C. A., Fercoq, Frédéric, Fresquet, Maryline, Traves, William J., Yates, Laura L., Walker, Simone A., Molyneaux, Philip L., Kemp, Samuel V., Nicholson, Andrew G., Rice, Alexandra, Roberts, Edward, Lennon, Rachel, Carlin, Leo M., Byrne, Adam J., Maher, Toby M., and Lloyd, Clare M.
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- 2023
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5. Continuous positive airway pressure treatment of obstructive sleep apnea and hypertensive complications in high-risk pregnancy
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Rice, Alexandra Lauren, Bajaj, Sakshi, Wiedmer, Abigail M., Jacobson, Natalie, Stanic, Aleksandar K., Antony, Kathleen M., and Bazalakova, Mihaela H.
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- 2023
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6. Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection
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Lunardi, Francesca, Vedovelli, Luca, Pezzuto, Federica, Le Pavec, Jerome, Dorfmuller, Peter, Ivanovic, Marina, Pena, Tahuanty, Wassilew, Katharina, Perch, Michael, Hirschi, Sandrine, Chenard, Marie-Pierre, Sosa, Rebecca A., Goddard, Martin, Neil, Desley, Montero-Fernandez, Angeles, Rice, Alexandra, Cozzi, Emanuele, Rea, Federico, Levine, Deborah J., Roux, Antoine, Fishbein, Gregory A., and Calabrese, Fiorella
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- 2024
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7. Public health perinatal promotion during COVID-19 pandemic: a social media analysis
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Durowaye, Toluwanimi D., Rice, Alexandra R., Konkle, Anne T. M., and Phillips, Karen P.
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- 2022
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8. Large cell neuroendocrine lung carcinoma: consensus statement from The British Thoracic Oncology Group and the Association of Pulmonary Pathologists
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Lindsay, Colin R., Shaw, Emily C., Moore, David A., Rassl, Doris, Jamal-Hanjani, Mariam, Steele, Nicola, Naheed, Salma, Dick, Craig, Taylor, Fiona, Adderley, Helen, Black, Fiona, Summers, Yvonne, Evans, Matt, Rice, Alexandra, Fabre, Aurelie, Wallace, William A., Nicholson, Siobhan, Haragan, Alex, Taniere, Phillipe, Nicholson, Andrew G., Laing, Gavin, Cave, Judith, Forster, Martin D., Blackhall, Fiona, Gosney, John, Popat, Sanjay, and Kerr, Keith M.
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- 2021
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9. Racial and ethnic determinants of psoriatic arthritis phenotypes and disease activity
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Haberman, Rebecca H, primary, Ahmed, Tasneem, additional, Um, Seungha, additional, Zhou, Ying Yin, additional, Catron, Sydney, additional, Jano, Kathryn, additional, Felipe, Adamary, additional, Eichman, Stephanie, additional, Rice, Alexandra L, additional, Lydon, Eileen, additional, Moussavi, Sarah, additional, Neimann, Andrea L, additional, Reddy, Soumya M, additional, Adhikari, Samrachana, additional, and Scher, Jose U, additional
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- 2024
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10. Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection
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Lunardi, Francesca, primary, Vedovelli, Luca, additional, Pezzuto, Federica, additional, Le Pavec, Jerome, additional, Dorfmuller, Peter, additional, Ivanovic, Marina, additional, Pena, Tahuanty, additional, Wassilew, Katharina, additional, Perch, Michael, additional, Hirschi, Sandrine, additional, Chenard, Marie-Pierre, additional, Sosa, Rebecca A., additional, Goddard, Martin, additional, Neil, Desley, additional, Montero-Fernandez, Angeles, additional, Rice, Alexandra, additional, Cozzi, Emanuele, additional, Rea, Federico, additional, Levine, Deborah J., additional, Roux, Antoine, additional, Fishbein, Gregory A., additional, and Calabrese, Fiorella, additional
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- 2023
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11. The respiratory system
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Rice, Alexandra, primary
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- 2020
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12. Reverse Takotsubo Cardiomyopathy and Cardiogenic Shock Associated With Methamphetamine Consumption
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Chehab, Omar, Ioannou, Adam, Sawhney, Akshat, Rice, Alexandra, and Dubrey, Simon
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- 2017
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13. 21 - Congenital Lung Disease
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Bush, Andrew, Abbasi, Nimrah, Clarke, Simon, Surg, Paed, Hewitt, Richard, Jordan, Simon, and Rice, Alexandra
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- 2024
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14. Prediction of next generation sequencing test failure in lung adenocarcinoma in a genomic laboratory hub setting
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Zhang, Yu Zhi, primary, Sherlock, Stuart, additional, MacMahon, Suzanne, additional, Brambilla, Cecilia, additional, Rice, Alexandra, additional, Robertus, Jan Lukas, additional, Wassilew, Katharina, additional, Lim, Eric, additional, Begum, Sofina, additional, Buderi, Silviu, additional, Jordan, Simon, additional, Anikin, Vladimir, additional, Finch, Jonathan, additional, Asadi, Nizar, additional, Beddow, Emma, additional, Garner, Justin L, additional, Morjaria, Jaymin, additional, Lee, Richard, additional, McDonald, Fiona, additional, Antoniou, Georgios, additional, Ridge, Carole, additional, Padley, Simon, additional, Dalal, Paras, additional, Morris-Rosendahl, Deborah, additional, Valganon-Petrizan, Mikel, additional, Shah, Pallav L, additional, Devaraj, Anand, additional, Popat, Sanjay, additional, and Nicholson, Andrew G, additional
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- 2023
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15. Pathology of Acute Cellular Rejection
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Neil, Desley A. H., Rice, Alexandra J., Leone, Ornella, editor, Angelini, Annalisa, editor, Bruneval, Patrick, editor, and Potena, Luciano, editor
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- 2016
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16. Utility of Nuclear Grading System in Epithelioid Malignant Pleural Mesothelioma in Biopsy-heavy Setting: An External Validation Study of 563 Cases
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Zhang, Yu Zhi, Brambilla, Cecilia, Molyneaux, Philip L., Rice, Alexandra, Robertus, Jan L., Jordan, Simon, Lim, Eric, Lang-Lazdunski, Loic, Begum, Sofina, Dusmet, Michael, Anikin, Vladimir, Beddow, Emma, Finch, Jonathan, Asadi, Nizar, Popat, Sanjay, Cookson, William O.C., Moffatt, Miriam F., and Nicholson, Andrew G.
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- 2020
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17. Body composition and lung cancer-associated cachexia in TRACERx
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Al-Sawaf, Othman, Weiss, Jakob, Skrzypski, Marcin, Lam, Jie Min, Karasaki, Takahiro, Zambrana, Francisco, Kidd, Andrew C, Frankell, Alexander M, Watkins, Thomas BK, Martinez-Ruiz, Carlos, Puttick, Clare, Black, James RM, Huebner, Ariana, Al Bakir, Maise, Sokac, Mateo, Collins, Susie, Veeriah, Selvaraju, Magno, Neil, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Ward, Sophia, Jayanth, Nick, Salgado, Roberto, Bridge, Christopher P, Christiani, David C, Mak, Raymond H, Bay, Camden, Rosenthal, Michael, Sattar, Naveed, Welsh, Paul, Liu, Ying, Perrimon, Norbert, Popuri, Karteek, Beg, Mirza Faisal, McGranahan, Nicholas, Hackshaw, Allan, Breen, Danna M, O'Rahilly, Stephen, Birkbak, Nicolai J, Aerts, Hugo JWL, Jamal-Hanjani, Mariam, Swanton, Charles, Lester, Jason F, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Fennell, Dean A, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joan, Primrose, Lindsay, Boleti, Ekaterini, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Price, Gillian, Kerr, Keith M, Benafif, Sarah, Gilbert, Kayleigh, Naidu, Babu, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Middleton, Gary, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Lindsay, Colin R, Blackhall, Fiona H, Krebs, Matthew G, Summers, Yvonne, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Dive, Caroline, Schwarz, Roland F, Kaufmann, Tom L, Wilson, Gareth A, Rosenthal, Rachel, Van Loo, Peter, Szallasi, Zoltan, Kisistok, Judit, Diossy, Miklos, Demeulemeester, Jonas, Bunkum, Abigail, Stewart, Aengus, Magness, Alastair, Rowan, Andrew, Karamani, Angeliki, Chain, Benny, Campbell, Brittany B, Castignani, Carla, Bailey, Chris, Abbosh, Christopher, Weeden, Clare E, Lee, Claudia, Richard, Corentin, Hiley, Crispin T, Moore, David A, Pearce, David R, Karagianni, Despoina, Biswas, Dhruva, Levi, Dina, Hoxha, Elena, Cadieux, Elizabeth Larose, Lim, Emilia L, Colliver, Emma, Nye, Emma, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Gimeno-Valiente, Francisco, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Zhai, Haoran, Lowe, Helen L, Matos, Ignacio Garcia, Goldman, Jacki, Reading, James L, Herrero, Javier, Rane, Jayant K, Nicod, Jerome, Hartley, John A, Peggs, Karl S, Enfield, Katey SS, Selvaraju, Kayalvizhi, Thol, Kerstin, Litchfield, Kevin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Grigoriadis, Kristiana, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Duran, Marcos Vasquez, Litovchenko, Maria, Sunderland, Mariana Werner, Hill, Mark S, Dietzen, Michelle, Leung, Michelle, Escudero, Mickael, Angelova, Mihaela, Tanic, Miljana, Sivakumar, Monica, Kanu, Nnennaya, Chervova, Olga, Lucas, Olivia, Pich, Oriol, Hobson, Philip, Pawlik, Piotr, Stone, Richard Kevin, Bentham, Robert, Hynds, Robert E, Vendramin, Roberto, Saghafinia, Sadegh, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Quezada, Sergio A, Vanloo, Sharon, Zaccaria, Simone, Hessey, Sonya, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Marafioti, Teresa, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Liu, Wing Kin, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Forster, Martin D, Lee, Siow Ming, Borg, Elaine, Falzon, Mary, Papadatos-Pastos, Dionysis, Wilson, James, Ahmad, Tanya, Procter, Alexander James, Ahmed, Asia, Taylor, Magali N, Nair, Arjun, Lawrence, David, Patrini, Davide, Navani, Neal, Thakrar, Ricky M, Janes, Sam M, Hoogenboom, Emilie Martinoni, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Cave, Judith, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, Lim, Eric, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Nicholson, Andrew G, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Hewish, Madeleine, Danson, Sarah, Shackcloth, Michael J, Robinson, Lily, Russell, Peter, Blyth, Kevin G, Dick, Craig, Le Quesne, John, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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Male ,Proteomics ,Cachexia ,Lung Neoplasms ,Antigens, Neoplasm ,Carcinoma, Non-Small-Cell Lung ,Body Weight ,Body Composition ,Humans ,Neoplasm Recurrence, Local ,Muscle, Skeletal ,Neoplasm Proteins - Abstract
Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in individuals with non-small cell lung cancer. Key features of CAC include alterations in body composition and body weight. Here, we explore the association between body composition and body weight with survival and delineate potential biological processes and mediators that contribute to the development of CAC. Computed tomography-based body composition analysis of 651 individuals in the TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy (Rx)) study suggested that individuals in the bottom 20th percentile of the distribution of skeletal muscle or adipose tissue area at the time of lung cancer diagnosis, had significantly shorter lung cancer-specific survival and overall survival. This finding was validated in 420 individuals in the independent Boston Lung Cancer Study. Individuals classified as having developed CAC according to one or more features at relapse encompassing loss of adipose or muscle tissue, or body mass index-adjusted weight loss were found to have distinct tumor genomic and transcriptomic profiles compared with individuals who did not develop such features. Primary non-small cell lung cancers from individuals who developed CAC were characterized by enrichment of inflammatory signaling and epithelial-mesenchymal transitional pathways, and differentially expressed genes upregulated in these tumors included cancer-testis antigen MAGEA6 and matrix metalloproteinases, such as ADAMTS3. In an exploratory proteomic analysis of circulating putative mediators of cachexia performed in a subset of 110 individuals from TRACERx, a significant association between circulating GDF15 and loss of body weight, skeletal muscle and adipose tissue was identified at relapse, supporting the potential therapeutic relevance of targeting GDF15 in the management of CAC. ispartof: NATURE MEDICINE vol:29 issue:4 ispartof: location:United States status: Published online
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- 2023
18. The evolution of non-small cell lung cancer metastases in TRACERx
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Al Bakir, Maise, Huebner, Ariana, Martinez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas BK, Pich, Oriol, Moore, David A, Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma, Frankell, Alexander, Bunkum, Abigail, Lim, Emilia L, Karasaki, Takahiro, Abbosh, Christopher, Hiley, Crispin T, Hill, Mark S, Cook, Daniel E, Wilson, Gareth A, Salgado, Roberto, Nye, Emma, Stone, Richard Kevin, Fennell, Dean A, Price, Gillian, Kerr, Keith M, Naidu, Babu, Middleton, Gary, Summers, Yvonne, Lindsay, Colin R, Blackhall, Fiona H, Cave, Judith, Blyth, Kevin G, Nair, Arjun, Ahmed, Asia, Taylor, Magali N, Procter, Alexander James, Falzon, Mary, Lawrence, David, Navani, Neal, Thakrar, Ricky M, Janes, Sam M, Papadatos-Pastos, Dionysis, Forster, Martin D, Lee, Siow Ming, Ahmad, Tanya, Quezada, Sergio, Peggs, Karl S, Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Birkbak, Nicolai J, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles, Lester, Jason F, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joan, Primrose, Lindsay, Boleti, Ekaterini, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Benafif, Sarah, Gilbert, Kayleigh, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Krebs, Matthew G, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Aerts, Hugo JWL, Schwarz, Roland F, Kaufmann, Tom L, Rosenthal, Rachel, Szallasi, Zoltan, Kisistok, Judit, Sokac, Mateo, Diossy, Miklos, Demeulemeester, Jonas, Stewart, Aengus, Magness, Alastair, Karamani, Angeliki, Chain, Benny, Campbell, Brittany B, Castignani, Carla, Bailey, Chris, Puttick, Clare, Weeden, Clare E, Lee, Claudia, Richard, Corentin, Pearce, David R, Karagianni, Despoina, Biswas, Dhruva, Levi, Dina, Hoxha, Elena, Larose Cadieux, Elizabeth, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Gimeno-Valiente, Francisco, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Zhai, Haoran, Lowe, Helen L, Matos, Ignacio, Goldman, Jacki, Reading, James L, Black, James RM, Herrero, Javier, Rane, Jayant K, Nicod, Jerome, Lam, Jie Min, Hartley, John A, Enfield, Katey SS, Selvaraju, Kayalvizhi, Thol, Kerstin, Litchfield, Kevin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Vasquez, Marcos, Litovchenko, Maria, Werner Sunderland, Mariana, Leung, Michelle, Escudero, Mickael, Angelova, Mihaela, Tanic, Miljana, Sivakumar, Monica, Kanu, Nnennaya, Chervova, Olga, Lucas, Olivia, Al-Sawaf, Othman, Hobson, Philip, Pawlik, Piotr, Bentham, Robert, Hynds, Robert E, Vendramin, Roberto, Saghafinia, Sadegh, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Vanloo, Sharon, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Marafioti, Teresa, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Liu, Wing Kin, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Borg, Elaine, Wilson, James, Patrini, Davide, Martinoni Hoogenboom, Emilie, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, Lim, Eric, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Nicholson, Andrew G, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Hewish, Madeleine, Danson, Sarah, Shackcloth, Michael J, Robinson, Lily, Russell, Peter, Dick, Craig, Le Quesne, John, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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Clonal Evolution ,Cohort Studies ,Evolution, Molecular ,Lung Neoplasms ,Carcinoma, Non-Small-Cell Lung ,Disease Progression ,Humans ,Neoplasm Metastasis ,Neoplasm Recurrence, Local ,Clone Cells - Abstract
Metastatic disease is responsible for the majority of cancer-related deaths1. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse. ispartof: NATURE vol:616 issue:7957 ispartof: location:England status: Published online
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- 2023
19. The evolution of lung cancer and impact of subclonal selection in TRACERx
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Frankell, Alexander M, Dietzen, Michelle, Al Bakir, Maise, Lim, Emilia L, Karasaki, Takahiro, Ward, Sophia, Veeriah, Selvaraju, Colliver, Emma, Huebner, Ariana, Bunkum, Abigail, Hill, Mark S, Grigoriadis, Kristiana, Moore, David A, Black, James RM, Liu, Wing Kin, Thol, Kerstin, Pich, Oriol, Watkins, Thomas BK, Naceur-Lombardelli, Cristina, Cook, Daniel E, Salgado, Roberto, Wilson, Gareth A, Bailey, Chris, Angelova, Mihaela, Bentham, Robert, Martinez-Ruiz, Carlos, Abbosh, Christopher, Nicholson, Andrew G, Le Quesne, John, Biswas, Dhruva, Rosenthal, Rachel, Puttick, Clare, Hessey, Sonya, Lee, Claudia, Prymas, Paulina, Toncheva, Antonia, Smith, Jon, Xing, Wei, Nicod, Jerome, Price, Gillian, Kerr, Keith M, Naidu, Babu, Middleton, Gary, Blyth, Kevin G, Fennell, Dean A, Forster, Martin D, Lee, Siow Ming, Falzon, Mary, Hewish, Madeleine, Shackcloth, Michael J, Lim, Eric, Benafif, Sarah, Russell, Peter, Boleti, Ekaterini, Krebs, Matthew G, Lester, Jason F, Papadatos-Pastos, Dionysis, Ahmad, Tanya, Thakrar, Ricky M, Lawrence, David, Navani, Neal, Janes, Sam M, Dive, Caroline, Blackhall, Fiona H, Summers, Yvonne, Cave, Judith, Marafioti, Teresa, Herrero, Javier, Quezada, Sergio A, Peggs, Karl S, Schwarz, Roland F, Van Loo, Peter, Miedema, Daniel M, Birkbak, Nicolai J, Hiley, Crispin T, Hackshaw, Allan, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joa, Primrose, Lindsay, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Gilbert, Kayleigh, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Lindsay, Colin R, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Aerts, Hugo JWL, Kaufmann, Tom L, Szallasi, Zoltan, Kisistok, Judit, Sokac, Mateo, Diossy, Miklos, Demeulemeester, Jonas, Stewart, Aengus, Magness, Alastair, Rowan, Andrew, Karamani, Angeliki, Chain, Benny, Campbell, Brittany B, Castignani, Carla, Weeden, Clare E, Richard, Corentin, Pearce, David R, Karagianni, Despoina, Levi, Dina, Hoxha, Elena, Larose Cadieux, Elizabeth, Nye, Emma, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Gimeno-Valiente, Francisco, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Zhai, Haoran L, Lowe, Helen L, Matos, Ignacio, Goldman, Jacki, Reading, James L, Rane, Jayant K, Lam, Jie Min, Hartley, John A, Enfield, Katey SS, Selvaraju, Kayalvizhi, Litchfield, Kevin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Vasquez, Marcos, Litovchenko, Maria, Werner Sunderland, Mariana, Leung, Michelle, Escudero, Mickael, Tanic, Miljana, Sivakumar, Monica, Kanu, Nnennaya, Chervova, Olga, Lucas, Olivia, Al-Sawaf, Othman, Hobson, Philip, Pawlik, Piotr, Stone, Richard Kevin, Hynds, Robert E, Vendramin, Roberto, Saghafinia, Sadegh, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Vanloo, Sharon, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Borg, Elaine, Wilson, James, Procter, Alexander James, Ahmed, Asia, Taylor, Magali N, Nair, Arjun, Patrini, Davide, Martinoni Hoogenboom, Emilie, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Danson, Sarah, Robinson, Lily, Dick, Craig, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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Lung Neoplasms ,Treatment Outcome ,DNA Copy Number Variations ,Mutagenesis ,Carcinoma, Non-Small-Cell Lung ,Mutation ,Smoking ,Humans ,Adenocarcinoma of Lung ,Neoplasm Recurrence, Local ,Phylogeny - Abstract
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relationship between intratumour heterogeneity and clinical outcome. In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite patients having a history of smoking, 8% of lung adenocarcinomas lacked evidence of tobacco-induced mutagenesis. These tumours also had similar detection rates for EGFR mutations and for RET, ROS1, ALK and MET oncogenic isoforms compared with tumours in never-smokers, which suggests that they have a similar aetiology and pathogenesis. Large subclonal expansions were associated with positive subclonal selection. Patients with tumours harbouring recent subclonal expansions, on the terminus of a phylogenetic branch, had significantly shorter disease-free survival. Subclonal WGD was detected in 19% of tumours, and 10% of tumours harboured multiple subclonal WGDs in parallel. Subclonal, but not truncal, WGD was associated with shorter disease-free survival. Copy number heterogeneity was associated with extrathoracic relapse within 1 year after surgery. These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource. ispartof: NATURE vol:616 issue:7957 ispartof: location:England status: Published online
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- 2023
20. Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
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Karasaki, Takahiro, Moore, David A, Veeriah, Selvaraju, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Magno, Neil, Ward, Sophia, Al Bakir, Maise, Watkins, Thomas BK, Grigoriadis, Kristiana, Huebner, Ariana, Hill, Mark S, Frankell, Alexander M, Abbosh, Christopher, Puttick, Clare, Zhai, Haoran, Gimeno-Valiente, Francisco, Saghafinia, Sadegh, Kanu, Nnennaya, Dietzen, Michelle, Pich, Oriol, Lim, Emilia L, Martinez-Ruiz, Carlos, Black, James RM, Biswas, Dhruva, Campbell, Brittany B, Lee, Claudia, Colliver, Emma, Enfield, Katey SS, Hessey, Sonya, Hiley, Crispin T, Zaccaria, Simone, Litchfield, Kevin, Birkbak, Nicolai J, Cadieux, Elizabeth Larose, Demeulemeester, Jonas, Van Loo, Peter, Adusumilli, Prasad R, Tan, Kay See, Cheema, Waseem, Sanchez-Vega, Francisco, Jones, David R, Rekhtman, Natasha, Travis, William D, Hackshaw, Allan, Marafioti, Teresa, Salgado, Roberto, Le Quesne, John, Nicholson, Andrew G, McGranahan, Nicholas, Swanton, Charles, Jamal-Hanjani, Mariam, Lester, Jason F, Bajaj, Amrita, Nakas, Apostolos, Sodha-Ramdeen, Azmina, Ang, Keng, Tufail, Mohamad, Chowdhry, Mohammed Fiyaz, Scotland, Molly, Boyles, Rebecca, Rathinam, Sridhar, Wilson, Claire, Marrone, Domenic, Dulloo, Sean, Fennell, Dean A, Matharu, Gurdeep, Shaw, Jacqui A, Riley, Joan, Primrose, Lindsay, Boleti, Ekaterini, Cheyne, Heather, Khalil, Mohammed, Richardson, Shirley, Cruickshank, Tracey, Price, Gillian, Kerr, Keith M, Benafif, Sarah, Gilbert, Kayleigh, Naidu, Babu, Patel, Akshay J, Osman, Aya, Lacson, Christer, Langman, Gerald, Shackleford, Helen, Djearaman, Madava, Kadiri, Salma, Middleton, Gary, Leek, Angela, Hodgkinson, Jack Davies, Totten, Nicola, Montero, Angeles, Smith, Elaine, Fontaine, Eustace, Granato, Felice, Doran, Helen, Novasio, Juliette, Rammohan, Kendadai, Joseph, Leena, Bishop, Paul, Shah, Rajesh, Moss, Stuart, Joshi, Vijay, Crosbie, Philip, Gomes, Fabio, Brown, Kate, Carter, Mathew, Chaturvedi, Anshuman, Priest, Lynsey, Oliveira, Pedro, Lindsay, Colin R, Blackhall, Fiona H, Krebs, Matthew G, Summers, Yvonne, Clipson, Alexandra, Tugwood, Jonathan, Kerr, Alastair, Rothwell, Dominic G, Kilgour, Elaine, Dive, Caroline, Aerts, Hugo JWL, Schwarz, Roland F, Kaufmann, Tom L, Wilson, Gareth A, Rosenthal, Rachel, Szallasi, Zoltan, Kisistok, Judit, Sokac, Mateo, Diossy, Miklos, Bunkum, Abigail, Stewart, Aengus, Magness, Alastair, Rowan, Andrew, Karamani, Angeliki, Chain, Benny, Castignani, Carla, Bailey, Chris, Weeden, Clare E, Richard, Corentin, Pearce, David R, Karagianni, Despoina, Levi, Dina, Hoxha, Elena, Nye, Emma, Gronroos, Eva, Galvez-Cancino, Felip, Athanasopoulou, Foteini, Kassiotis, George, Stavrou, Georgia, Mastrokalos, Gerasimos, Lowe, Helen L, Matos, Ignacio Garcia, Goldman, Jacki, Reading, James L, Herrero, Javier, Rane, Jayant K, Nicod, Jerome, Lam, Jie Min, Hartley, John A, Peggs, Karl S, Selvaraju, Kayalvizhi, Thol, Kerstin, Ng, Kevin W, Chen, Kezhong, Dijkstra, Krijn, Thakkar, Krupa, Ensell, Leah, Shah, Mansi, Duran, Marcos Vasquez, Litovchenko, Maria, Sunderland, Mariana Werner, Leung, Michelle, Escudero, Mickael, Angelova, Mihaela, Tanic, Miljana, Sivakumar, Monica, Chervova, Olga, Lucas, Olivia, Al-Sawaf, Othman, Prymas, Paulina, Hobson, Philip, Pawlik, Piotr, Stone, Richard Kevin, Bentham, Robert, Hynds, Robert E, Vendramin, Roberto, Lopez, Saioa, Gamble, Samuel, Ung, Seng Kuong Anakin, Quezada, Sergio A, Vanloo, Sharon, Boeing, Stefan, Beck, Stephan, Bola, Supreet Kaur, Denner, Tamara, Mourikis, Thanos P, Spanswick, Victoria, Barbe, Vittorio, Lu, Wei-Ting, Hill, William, Liu, Wing Kin, Wu, Yin, Naito, Yutaka, Ramsden, Zoe, Veiga, Catarina, Royle, Gary, Collins-Fekete, Charles-Antoine, Fraioli, Francesco, Ashford, Paul, Clark, Tristan, Forster, Martin D, Lee, Siow Ming, Borg, Elaine, Falzon, Mary, Papadatos-Pastos, Dionysis, Wilson, James, Ahmad, Tanya, Procter, Alexander James, Ahmed, Asia, Taylor, Magali N, Nair, Arjun, Lawrence, David, Patrini, Davide, Navani, Neal, Thakrar, Ricky M, Janes, Sam M, Hoogenboom, Emilie Martinoni, Monk, Fleur, Holding, James W, Choudhary, Junaid, Bhakhri, Kunal, Scarci, Marco, Hayward, Martin, Panagiotopoulos, Nikolaos, Gorman, Pat, Khiroya, Reena, Stephens, Robert CM, Wong, Yien Ning Sophia, Bandula, Steve, Sharp, Abigail, Smith, Sean, Gower, Nicole, Dhanda, Harjot Kaur, Chan, Kitty, Pilotti, Camilla, Leslie, Rachel, Grapa, Anca, Zhang, Hanyun, AbdulJabbar, Khalid, Pan, Xiaoxi, Yuan, Yinyin, Chuter, David, MacKenzie, Mairead, Chee, Serena, Alzetani, Aiman, Cave, Judith, Scarlett, Lydia, Richards, Jennifer, Ingram, Papawadee, Austin, Silvia, Lim, Eric, De Sousa, Paulo, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Bhayani, Harshil, Ambrose, Lyn, Devaraj, Anand, Chavan, Hema, Begum, Sofina, Buderi, Silviu, Kaniu, Daniel, Malima, Mpho, Booth, Sarah, Fernandes, Nadia, Shah, Pratibha, Proli, Chiara, Hewish, Madeleine, Danson, Sarah, Shackcloth, Michael J, Robinson, Lily, Russell, Peter, Blyth, Kevin G, Dick, Craig, Kirk, Alan, Asif, Mo, Bilancia, Rocco, Kostoulas, Nikos, and Thomas, Mathew
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TRACERx Consortium - Abstract
Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and micropapillary tumors. How morphology reflects tumor evolution and disease progression is poorly understood. Whole-exome sequencing data generated from 805 primary tumor regions and 121 paired metastatic samples across 248 LUADs from the TRACERx 421 cohort, together with RNA-sequencing data from 463 primary tumor regions, were integrated with detailed whole-tumor and regional histopathological analysis. Tumors with predominantly high-grade patterns showed increased chromosomal complexity, with higher burden of loss of heterozygosity and subclonal somatic copy number alterations. Individual regions in predominantly high-grade pattern tumors exhibited higher proliferation and lower clonal diversity, potentially reflecting large recent subclonal expansions. Co-occurrence of truncal loss of chromosomes 3p and 3q was enriched in predominantly low-/mid-grade tumors, while purely undifferentiated solid-pattern tumors had a higher frequency of truncal arm or focal 3q gains and SMARCA4 gene alterations compared with mixed-pattern tumors with a solid component, suggesting distinct evolutionary trajectories. Clonal evolution analysis revealed that tumors tend to evolve toward higher-grade patterns. The presence of micropapillary pattern and 'tumor spread through air spaces' were associated with intrathoracic recurrence, in contrast to the presence of solid/cribriform patterns, necrosis and preoperative circulating tumor DNA detection, which were associated with extra-thoracic recurrence. These data provide insights into the relationship between LUAD morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk. ispartof: NATURE MEDICINE vol:29 issue:4 ispartof: location:United States status: Published online
- Published
- 2023
21. Alveolar Septal Widening as an “Alert” Signal to Look Into Lung Antibody-mediated Rejection: A Multicenter Pilot Study
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Calabrese, Fiorella, Hirschi, Sandrine, Neil, Desley, Montero-Fernandez, Angeles, Timens, Wim, Verbeken, Erik, Chenard, Marie-Pierre, Ivanovic, Marina, Le Pavec, Jerome, Pena, Tahuanty, Dorfmüller, Peter, Roux, Antoine, Rice, Alexandra, Perissinotto, Egle, Lunardi, Francesca, Levine, Deborah J., Cozzi, Emanuele, and Goddard, Martin
- Published
- 2019
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22. Vaginal discharge
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Rice, Alexandra, ElWerdany, Mohamed, Hadoura, Essam, and Mahmood, Tahir
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- 2016
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23. Determinants of non-completion of sleep apnea testing during pregnancy
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Antony, Kathleen M., primary, Rice, Alexandra Lauren, additional, Bajaj, Sakshi, additional, Wiedmer, Abigail M., additional, Jacobson, Natalie, additional, Nick, Julia, additional, Eichmann, Allison, additional, Stanic, Aleksandar K., additional, and Bazalakova, Mihaela H., additional
- Published
- 2023
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- View/download PDF
24. Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis.
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Hewitt, Richard J., Puttur, Franz, Gaboriau, David C. A., Fercoq, Frédéric, Fresquet, Maryline, Traves, William J., Yates, Laura L., Walker, Simone A., Molyneaux, Philip L., Kemp, Samuel V., Nicholson, Andrew G., Rice, Alexandra, Roberts, Edward, Lennon, Rachel, Carlin, Leo M., Byrne, Adam J., Maher, Toby M., and Lloyd, Clare M.
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EXTRACELLULAR matrix ,PULMONARY fibrosis ,LUNGS ,IDIOPATHIC pulmonary fibrosis ,CELL migration ,TISSUE remodeling - Abstract
Aberrant expansion of KRT5
+ basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT5+ cells in IPF have not been delineated. Here, we reveal a potential mechanism by which KRT5+ cells migrate within the fibrotic lung, navigating regional differences in collagen topography. In vitro, KRT5+ cell migratory characteristics and expression of remodelling genes are modulated by extracellular matrix (ECM) composition and organisation. Mass spectrometry- based proteomics revealed compositional differences in ECM components secreted by primary human lung fibroblasts (HLF) from IPF patients compared to controls. Over-expression of ECM glycoprotein, Secreted Protein Acidic and Cysteine Rich (SPARC) in the IPF HLF matrix restricts KRT5+ cell migration in vitro. Together, our findings demonstrate how changes to the ECM in IPF directly influence KRT5+ cell behaviour and function contributing to remodelling events in the fibrotic niche. Idiopathic pulmonary fibrosis has been associated with aberrant expansion of KRT5-expressing basal cells. Here the authors show how changes in the ECM glycoprotein SPARC restrict the movement of KRT5+ cells, affecting their retention within fibrotic tissue. [ABSTRACT FROM AUTHOR]- Published
- 2023
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25. Lung extracellular matrix modulates KRT5+basal cell activity in pulmonary fibrosis
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Hewitt, Richard J., primary, Puttur, Franz, additional, Gaboriau, David C. A., additional, Fercoq, Frédéric, additional, Fresquet, Maryline, additional, Traves, William J., additional, Yates, Laura L., additional, Walker, Simone A., additional, Molyneaux, Philip L., additional, Kemp, Samuel V., additional, Nicholson, Andrew G., additional, Rice, Alexandra, additional, Lennon, Rachel, additional, Carlin, Leo M., additional, Byrne, Adam J., additional, Maher, Toby M., additional, and Lloyd, Clare M., additional
- Published
- 2022
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- View/download PDF
26. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
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Abbosh, Christopher, Birkbak, Nicolai J., Wilson, Gareth A., Jamal-Hanjani, Mariam, Constantin, Tudor, Salari, Raheleh, Le Quesne, John, Moore, David A., Veeriah, Selvaraju, Rosenthal, Rachel, Marafioti, Teresa, Kirkizlar, Eser, Watkins, Thomas B. K., McGranahan, Nicholas, Ward, Sophia, Martinson, Luke, Riley, Joan, Fraioli, Francesco, Al Bakir, Maise, Grnroos, Eva, Zambrana, Francisco, Endozo, Raymondo, Bi, Wenya Linda, Fennessy, Fiona M., Sponer, Nicole, Johnson, Diana, Laycock, Joanne, Shafi, Seema, Czyzewska-Khan, Justyna, Rowan, Andrew, Chambers, Tim, Matthews, Nik, Turajlic, Samra, Hiley, Crispin, Lee, Siow Ming, Forster, Martin D., Ahmad, Tanya, Falzon, Mary, Borg, Elaine, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M., Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Summers, Yvonne, Hafez, Dina, Naik, Ashwini, Ganguly, Apratim, Kareht, Stephanie, Shah, Rajesh, Joseph, Leena, Marie Quinn, Anne, Crosbie, Phil A., Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A., Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F., Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Oukrif, Dahmane, Akarca, Ayse U., Hartley, John A., Lowe, Helen L., Lock, Sara, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Elgar, Greg, Szallasi, Zoltan, Schwarz, Roland F., Herrero, Javier, Stewart, Aengus, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Lin, C. Jimmy, Rabinowitz, Matthew, Aerts, Hugo J. W. L., Hackshaw, Allan, Shaw, Jacqui A., Zimmermann, Bernhard G., Swanton, Charles, Bosshard-Carter, Leticia, Goh, Gerald, Gorman, Pat, Murugaesu, Nirupa, Hynds, Robert E., Horswell, Stuart, Bakir, Maise Al, Mitter, Richard, Escudero, Mickael, Xu, Hang, Goldman, Jacki, Stone, Richard Kevin, Denner, Tamara, Biggs, Jennifer, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Nye, Emma, Graca, Sofia, Joshi, Kroopa, Furness, Andrew, Ben Aissa, Assma, Wong, Yien Ning Sophia, Georgiou, Andy, Simeon, Celia, Hector, Gemma, Smith, Amy, Aranda, Marie, Novelli, Marco, Papadatos-Pastos, Dionysis, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Taylor, Magali, Choudhary, Junaid, Califano, Raffaele, Taylor, Paul, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Moss, Stuart, Idries, Faiza, Bishop, Paul, Chaturvedi, Anshuman, Quinn, Anne Marie, Doran, Helen, Leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Rogan, Jane, Smith, Elaine, Tugwood, Jonathan, Brady, Ged, Rothwell, Dominic G., Chemi, Francesca, Pierce, Jackie, Gulati, Sakshi, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Djearaman, Madava, Quesne, John Le, Thomas, Anne, Walter, Harriet, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Primrose, Lindsay, Amadi, Anita, Palmer, Shirley, Miller, Joy, Buchan, Keith, Edwards, Alison, Morgan, Fiona, Verjee, Azmina, MacKenzie, Mairead, Wilcox, Maggie, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Barbosa, Monica Tavares, Bowman, Alex, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Cufari, Maria Elena, Ronquillo, John Carlo, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Nicholson, Andrew G., Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Light, Teresa, Horey, Tracey, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Fisher, Patricia, Keerio, Allah Dino, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, Asante-Siaw, Julius, Dentro, Stefan, and Dessimoz, Christophe
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Lung cancer -- Genetic aspects -- Development and progression ,DNA sequencing -- Methods ,Phylogeny -- Observations ,Cancer metastasis -- Genetic aspects ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies., Author(s): Christopher Abbosh [1]; Nicolai J. Birkbak [1, 2]; Gareth A. Wilson [1, 2]; Mariam Jamal-Hanjani [1]; Tudor Constantin [3]; Raheleh Salari [3]; John Le Quesne [4]; David A. Moore [...]
- Published
- 2017
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27. Generalizability of landmark clinical trials in diffuse large B cell lymphoma to real-world patients: a single-center retrospective cohort study
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Davidson, Marta B., primary, Rice, Alexandra, additional, Stewart, Douglas, additional, and Owen, Carolyn, additional
- Published
- 2022
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28. Pleuroparenchymal Fibroelastosis: A Review of Histopathologic Features and the Relationship Between Histologic Parameters and Survival
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Khiroya, Reena, Macaluso, Claudio, Montero, Maria A., Wells, Athol U., Chua, Felix, Kokosi, Maria, Maher, Toby M., Devaraj, Anand, Rice, Alexandra, Renzoni, Elisabetta A., and Nicholson, Andrew G.
- Published
- 2017
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29. Wheeze in the time of COVID-19: overcoming obstacles to an unusual diagnosis
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Barclay, Mhairi, primary, Buderi, Silviu, additional, Bush, Andrew, additional, Daniel, Mat, additional, Jordan, Simon, additional, Rice, Alexandra, additional, Ruggins, Nigel, additional, Semple, Thomas, additional, and Smyth, Alan Robert, additional
- Published
- 2022
- Full Text
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30. Continuous positive airway pressure treatment of obstructive sleep apnea and hypertensive complications in high-risk pregnancy
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Rice, Alexandra Lauren, primary, Bajaj, Sakshi, additional, Wiedmer, Abigail M., additional, Jacobson, Natalie, additional, Stanic, Aleksandar K., additional, Antony, Kathleen M., additional, and Bazalakova, Mihaela H., additional
- Published
- 2022
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- View/download PDF
31. Clinical Application of a Previously Validated Pregnancy-Specific Screening Tool for Sleep Apnea [A165]
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Bajaj, Sakshi, primary, Rice, Alexandra L., additional, Jones, Nathan, additional, Jacobson, Natalie, additional, Bazalakova, Mihaela, additional, and Antony, Kathleen M., additional
- Published
- 2022
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32. Unusual cause of chest pain: empyema necessitans and tubercular osteomyelitis of the rib in an immunocompetent man
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Dunphy, Louise, Shetty, Prashanth, Kavidasan, Ajitkumar, and Rice, Alexandra
- Published
- 2016
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33. Bronchial Dieulafoy Lesion. A 20-Year History of Unexplained Hemoptysis
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Hadjiphilippou, Savvas, Shah, Pallav L., Rice, Alexandra, Padley, Simon, and Hind, Matthew
- Published
- 2017
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34. Reducing fixation time significantly reduces failure rates: an audit of failure rates and turn-around times on next generation sequencing (NGS) of non-small lung carcinomas
- Author
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Sherlock, Stuart, primary, Zhang, Yu Zhi, additional, Ly, Fabrice, additional, MacMahon, Suzanne, additional, Thompson, Lisa, additional, Lim, Eric, additional, Popat, Sanjay, additional, Antoniou, Georgios, additional, Robertus, Jan Lukas, additional, Rice, Alexandra, additional, Brambilla, Cecilia, additional, and Nicholson, Andrew, additional
- Published
- 2022
- Full Text
- View/download PDF
35. Poor progress in labour
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Tydeman, Graham, primary and Rice, Alexandra, additional
- Published
- 2016
- Full Text
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36. List of Contributors
- Author
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Abbasi, Nimrah, Abman, Steven, Alton, Eric, Amin, Raouf Samy, Au, Chun Ting, Balfour-Lynn, Ian Michael, Barber, Andrew T., Bar-Yoseph, Ronen, Benscoter, Dan, Blatter, Joshua A., Boesch, Richard Paul, Brochard, Laurent J., Burchett, Saskia, Bush, Andrew, Butler, Colin, Cardenas, Juan Alberto, Chan, Kate Ching-Ching, Chang, Anne B., Chao, Stephanie D., Chatwin, Michelle, Chaudhari, Bimal Pankaj, Cheifetz, Ira M., Chen, Maida Lynn, Chiu, Priscilla P.L., Clarke, Nora Katherine, Clarke, Simon, Collins, Nicola, Cooper, Dan Michael, Cornfield, David, Coverstone, Andrea M., Cunningham, Aaron, Cunningham, Steven, Custovic, Adnan, Cutting, Garry R., Daley, Charles L., Davies, Jane Carolyn, De Guzman, Marietta Morales, Dealarcon, Alessandro, Dell, Sharon D., Dellon, Elisabeth P., Deterding, Robin, Deutsch, Gail H., Dorsey, Jill, Ducharme, Francine M., Davis, Stephanie Duggins, Curnen, Edward C., Jr., Dutmer, Cullen Matthew, Engelhardt, John, Everard, Mark, Faigen, Elyssa B., Farber, Harold J., Faro, Albert, Ferkol, Thomas W., Fleming, Louise, Fontanella, Sara, Frohlich, Megan, Gauld, Leanne M., Gazit, Avihu Z., Georgiopoulos, Anna M., Goussard, Pierre, Gozal, David, Gray, Diane M., Greenough, Anne, Grigg, Jonathan, Gupta, Atul, Hagood, James S., Hammer, Jürg, Varela, Fernanda Hammes, Hamvas, Aaron, Hauk, Pia Johanna, Hazan, Guy, Heininger, Ulrich, Henry, Marianna Matthews, Hewitt, Richard, Hillman, Noah H., Hogg, Claire, Hughes, Dominic, Hyun, Jeong S., Ishak, Alya, Jaffé, Adam, Janssens, Hettie M., Jennings, Lance C., Jordan, Simon, Kamdar, Ankur A., Katira, Bhushan H., Kemp, James, Kheirandish-Gozal, Leila, King, John Andrew, King, Wilson, Kingma, Paul S., Krishnan, Usha S., Kuklinski, Cadence, Kurland, Geoffrey, Lam, Hugh Simon, Lee, Ada, Lesser, Daniel J., Lethbridge, Robert, Liptzin, Deborah, Lloyd, Clare M., Lovinsky-Desir, Stephanie, Maholtz, Danielle, Martiniano, Stacey L., Maybee, Jennifer, McBeth, Katrina E., McDowell, Karen M., McGrath-Morrow, Sharon A., McKinzie, Cameron J., Miller, Aaron Samuel, Miller, Claire Kane, Mirza, Ayesha, Mokhallati, Nadine, Murdoch, David R., Muston, Heather N., Narang, Indra, Newth, Christopher, Nick, Jerry A., Noah, Terry, Nogee, Lawrence M., Noyes, Blakeslee, Numa, Andrew, O'Brodovich, Hugh, Ochs, Matthias, Oikonomopoulou, Zacharoula, Olin, J. Tod, Olsen, Øystein E., Abdulmalik Osman, Mubarak Mardi, Owens, Catherine, Pabary, Rishi, Panitch, Howard B., Pascoe, John, Pearce, Neil, Pentiuk, Scott, Pineault, Kyriel, Pollak, Mordechai, Prager, Jeremy David, Praud, Jean-Paul, Prayle, Andrew, Prentice, Bernadette, Putnam, Philip, Quittner, Alexandra L., Radom-Aizik, Shlomit, Ramjist, Joshua K., Rathore, Mobeen, Ratjen, Felix, Redding, Gregory, Ren, Clement L., Rice, Alexandra, Rodriguez-Guerineau, Luciana, Rosenzweig, Erika B., Rutter, Michael, Saglani, Sejal, Schowengerdt, Kenneth O., Schultz, André, Scotta, Marcelo Comerlato, Semple, Thomas, Sherlock, Laurie, Shingleton, Emilia, Singhal, Graciaa, Sly, Peter D., Smith, Beth, Solomon, Melinda, Spahr, Jonathan, Stark, James M., Starke, Jeffrey Robert, Stein, Renato T., Stillwell, Paul C., Stokes, Dennis, Sullivan, Jillian, Sveen, William, Swarr, Daniel T., Sweet, Stuart Charles, Varisco, Brian Michael, Vece, Timothy, Vyas, Harish G., Wakeman, Ruth, Wallis, Colin, Wambach, Jennifer, Wee, Wallace, Weiner, Daniel J., Werno, Anja M., Whitsett, Jeffrey A., Whittaker, Elizabeth, Williams, Thomas Christie, Wilson, Andrew Charles, Wood, Robert E., Wootten, Christopher Todd, Wright, Sarah, Xu, Evan, Yao, Sijia, Young, Carolyn, Young, Heather, Young, Lisa R., Zar, Heather J., and Zeitlin, Pamela Leslie
- Published
- 2024
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37. Post-thymectomy myasthenia gravis: a case report and systematic review of literature
- Author
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Gurowich, Louise, primary, Maxwell, Adam, additional, Rice, Alexandra, additional, and Yiin, Gabriel, additional
- Published
- 2021
- Full Text
- View/download PDF
38. Non‐neoplastic respiratory fluid cytology including cell differential counts for interstitial lung disease
- Author
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Rice, Alexandra J., primary
- Published
- 2021
- Full Text
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39. Bombesin staining in neuroendocrine cell hyperplasia of infancy (NEHI) and other childhood interstitial lung diseases (chILD)
- Author
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Yancheva, Slaveya G, Velani, Asha, Rice, Alexandra, Montero, Angeles, Hansell, David M, Koo, Sergio, Thia, Lina, Bush, Andrew, and Nicholson, Andrew G
- Published
- 2015
- Full Text
- View/download PDF
40. Refining the Diagnosis and EGFR Status of Non-small Cell Lung Carcinoma in Biopsy and Cytologic Material, Using a Panel of Mucin Staining, TTF-1, Cytokeratin 5/6, and P63, and EGFR Mutation Analysis
- Author
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Nicholson, Andrew G., Gonzalez, David, Shah, Pallav, Pynegar, Matthew J., Deshmukh, Manjiri, Rice, Alexandra, and Popat, Sanjay
- Published
- 2010
- Full Text
- View/download PDF
41. Type A and AB thymomas: histological features associated with increased stage*
- Author
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Green, Anna C, Marx, Alexander, Ströbel, Philipp, Mason, Marianne, Lim, Eric, Jordan, Simon, Ladas, George, Dusmet, Michael, Rice, Alexandra, and Nicholson, Andrew G
- Published
- 2015
- Full Text
- View/download PDF
42. An audit of compliance with NOLCP in the GLH era
- Author
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Ly, Fabrice, primary, Brambilla, Cecilia, additional, Rice, Alexandra, additional, Robertus, Jan Lukas, additional, MacMahon, Suzanne, additional, Thompson, Lisa, additional, Antoniou, Georgios, additional, Popat, Sanjay, additional, and Nicholson, Andrew, additional
- Published
- 2021
- Full Text
- View/download PDF
43. The curious incident of the cast in the airway
- Author
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Ge, Yueqi, primary, Bartlett, Emily C, additional, Semple, Thomas, additional, Rice, Alexandra, additional, Shah, Anand, additional, and Renzoni, Elisabetta A, additional
- Published
- 2021
- Full Text
- View/download PDF
44. Diagnosis and Management of Male Breast Cancer
- Author
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Lanitis, Sophocles, Rice, Alexandra J., Vaughan, Alexander, Cathcart, Paul, Filippakis, George, Mufti, Ragheed Al, and Hadjiminas, Dimitri J.
- Published
- 2008
- Full Text
- View/download PDF
45. The Respiratory Microbiome in Chronic Hypersensitivity Pneumonitis Is Distinct from That of Idiopathic Pulmonary Fibrosis
- Author
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Invernizzi, Rachele, primary, Wu, Benjamin G., additional, Barnett, Joseph, additional, Ghai, Poonam, additional, Kingston, Shaun, additional, Hewitt, Richard J., additional, Feary, Johanna, additional, Li, Yonghua, additional, Chua, Felix, additional, Wu, Zhe, additional, Wells, Athol U., additional, George, Peter M., additional, Renzoni, Elisabetta A., additional, Nicholson, Andrew G., additional, Rice, Alexandra, additional, Devaraj, Anand, additional, Segal, Leopoldo N., additional, Byrne, Adam J., additional, Maher, Toby M., additional, Lloyd, Clare M., additional, and Molyneaux, Philip L., additional
- Published
- 2021
- Full Text
- View/download PDF
46. Diffuse lung disease in infancy and childhood: expanding the chILD classification
- Author
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Rice, Alexandra, Tran-Dang, My-Anh, Bush, Andrew, and Nicholson, Andrew G
- Published
- 2013
- Full Text
- View/download PDF
47. 1 - Prediction of next generation sequencing test failure in lung adenocarcinoma in a genomic laboratory hub setting
- Author
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Zhang, Yu Zhi, Sherlock, Stuart, MacMahon, Suzanne, Brambilla, Cecilia, Rice, Alexandra, Robertus, Jan Lukas, Wassilew, Katharina, Lim, Eric, Begum, Sofina, Buderi, Silviu, Jordan, Simon, Anikin, Vladimir, Finch, Jonathan, Asadi, Nizar, Beddow, Emma, Garner, Justin L, Morjaria, Jaymin, Lee, Richard, McDonald, Fiona, Antoniou, Georgios, Ridge, Carole, Padley, Simon, Dalal, Paras, Morris-Rosendahl, Deborah, Valganon-Petrizan, Mikel, Shah, Pallav L, Devaraj, Anand, Popat, Sanjay, and Nicholson, Andrew G
- Published
- 2023
- Full Text
- View/download PDF
48. Giant cell myocarditis in the CMR era
- Author
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Leong Tora, Wong Joyce, Rice Alexandra, Zidan Mamdouh, Hamilton Andrew, Ariff Ben, Chester Ruth, Rahman Haley Shelley L, Kelion Andrew, Burke Margaret M, Mitchell Andrew G, Banner Nicholas, and Mittal Tarun K
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2012
- Full Text
- View/download PDF
49. Generalizability of Landmark Clinical Trials in Diffuse Large B Cell Lymphoma to Real-World Patients: A Single-Centre Retrospective Cohort Study
- Author
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Davidson, Marta, primary, Rice, Alexandra, additional, Stewart, Douglas A., additional, and Owen, Carolyn, additional
- Published
- 2020
- Full Text
- View/download PDF
50. Mucinous adenocarcinoma arising in congenital pulmonary airway malformation: clinicopathological analysis of 37 cases
- Author
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Chang, Wei‐Chin, primary, Zhang, Yu Zhi, additional, Wolf, Janina L, additional, Hermelijn, Sergei M, additional, Schnater, J Marco, additional, Thüsen, Jan H, additional, Rice, Alexandra, additional, Lantuejoul, Sylvie, additional, Mastroianni, Bénédicte, additional, Farver, Carol, additional, Black, Fiona, additional, Popat, Sanjay, additional, and Nicholson, Andrew G, additional
- Published
- 2020
- Full Text
- View/download PDF
Catalog
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