252,870 results on '"Richard, M"'
Search Results
2. California Earthquake Dataset for Machine Learning and Cloud Computing
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Zhu, Weiqiang, Wang, Haoyu, Rong, Bo, Yu, Ellen, Zuzlewski, Stephane, Tepp, Gabrielle, Taira, Taka'aki, Marty, Julien, Husker, Allen, and Allen, Richard M
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Physics - Geophysics - Abstract
The San Andreas Fault system, known for its frequent seismic activity, provides an extensive dataset for earthquake studies. The region's well-instrumented seismic networks have been crucial in advancing research on earthquake statistics, physics, and subsurface Earth structures. In recent years, earthquake data from California has become increasingly valuable for deep learning applications, such as Generalized Phase Detection (GPD) for phase detection and polarity determination, and PhaseNet for phase arrival-time picking. The continuous accumulation of data, particularly those manually labeled by human analysts, serves as an essential resource for advancing both regional and global deep learning models. To support the continued development of machine learning and data mining studies, we have compiled a unified California Earthquake Event Dataset (CEED) that integrates seismic records from the Northern California Earthquake Data Center (NCEDC) and the Southern California Earthquake Data Center (SCEDC). The dataset includes both automatically and manually determined parameters such as earthquake origin time, source location, P/S phase arrivals, first-motion polarities, and ground motion intensity measurements. The dataset is organized in an event-based format organized by year spanning from 2000 to 2024, facilitating cross-referencing with event catalogs and enabling continuous updates in future years. This comprehensive open-access dataset is designed to support diverse applications including developing deep learning models, creating enhanced catalog products, and research into earthquake processes, fault zone structures, and seismic risks.
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- 2025
3. CIBER 4th flight fluctuation analysis: Pseudo-power spectrum formalism, improved source masking and validation on mocks
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Feder, Richard M., Bock, James J., Cheng, Yun-Ting, Cooray, Asantha, Korngut, Phillip M., Matsuura, Shuji, Nguyen, Chi H., Takimoto, Kohji, Zemcov, Michael, and collaboration, CIBER
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Precise, unbiased measurements of extragalactic background anisotropies require careful treatment of systematic effects in fluctuation-based, broad-band intensity mapping measurements. In this paper we detail improvements in methodology for the Cosmic Infrared Background ExpeRiment (CIBER), concentrating on flat field errors and source masking errors. In order to bypass the use of field differences, which mitigate flat field errors but reduce sensitivity, we characterize and correct for the flat field on pseudo-power spectra, which includes both additive and multiplicative biases. To more effectively mask point sources at 1.1 $\mu$m and 1.8 $\mu$m, we develop a technique for predicting masking catalogs that utilizes optical and NIR photometry through random forest regression. This allows us to mask over two Vega magnitudes deeper than the completeness limits of 2MASS alone, with errors in the shot noise power remaining below $<10\%$ at all masking depths considered. Through detailed simulations of CIBER observations, we validate our formalism and demonstrate unbiased recovery of the sky fluctuations on realistic mocks. We demonstrate that residual flat field errors comprise $<20\%$ of the final CIBER power spectrum uncertainty with this methodology., Comment: 29 pages, 17 figures. Submitted to ApJ
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- 2025
4. CIBER 4th flight fluctuation analysis: Measurements of near-IR auto- and cross-power spectra on arcminute to sub-degree scales
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Feder, Richard M., Bock, James J., Cheng, Yun-Ting, Cooray, Asantha, Korngut, Phillip M., Matsuura, Shuji, Mirocha, Jordan, Nguyen, Chi H., Takimoto, Kohji, Tsumura, Kohji, Wills, Ryan, Zemcov, Michael, and collaboration, CIBER
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present new anisotropy measurements in the near-infrared (NIR) for angular multipoles $300<\ell<10^5$ using imaging data at 1.1 $\mu$m and 1.8 $\mu$m from the fourth flight of the Cosmic Infrared Background ExpeRiment (CIBER). Using improved analysis methods and higher quality fourth flight data, we detect surface brightness fluctuations on scales $\ell<2000$ with CIBER auto-power spectra at $\sim14\sigma$ and 18$\sigma$ for 1.1 and 1.8 $\mu$m, respectively, and at $\sim10\sigma$ in cross-power spectra. The CIBER measurements pass internal consistency tests and represent a $5-10\times$ improvement in power spectrum sensitivity on several-arcminute scales relative to that of existing studies. Through cross-correlations with tracers of diffuse galactic light (DGL), we determine that scattered DGL contributes $<10\%$ to the observed fluctuation power at high confidence. On scales $\theta > 5'$, the CIBER auto- and cross-power spectra exceed predictions for integrated galactic light (IGL) and integrated stellar light (ISL) by over an order of magnitude, and are inconsistent with our baseline IGL+ISL+DGL model at high significance. We cross-correlate two of the CIBER fields with 3.6 $\mu$m and 4.5 $\mu$m mosaics from the Spitzer Deep Wide-Field Survey and find similar evidence for departures from Poisson noise in Spitzer-internal power spectra and CIBER $\times$ Spitzer cross-power spectra. A multi-wavelength analysis indicates that the auto-power of the fluctuations at low-$\ell$ is bluer than the Poisson noise from IGL and ISL; however, for $1' <\theta < 10'$, the cross-correlation coefficient $r_{\ell}$ of nearly all band combinations decreases with increasing $\theta$, disfavoring astrophysical explanations that invoke a single correlated sky component., Comment: 41 pages, 32 figures. Submitted to ApJ
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- 2025
5. Large-scale stochastic simulation of open quantum systems
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Sander, Aaron, Fröhlich, Maximilian, Eigel, Martin, Eisert, Jens, Gelß, Patrick, Hintermüller, Michael, Milbradt, Richard M., Wille, Robert, and Mendl, Christian B.
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Quantum Physics ,Condensed Matter - Other Condensed Matter - Abstract
Understanding the precise interaction mechanisms between quantum systems and their environment is crucial for advancing stable quantum technologies, designing reliable experimental frameworks, and building accurate models of real-world phenomena. However, simulating open quantum systems, which feature complex non-unitary dynamics, poses significant computational challenges that require innovative methods to overcome. In this work, we introduce the tensor jump method (TJM), a scalable, embarrassingly parallel algorithm for stochastically simulating large-scale open quantum systems, specifically Markovian dynamics captured by Lindbladians. This method is built on three core principles where, in particular, we extend the Monte Carlo wave function (MCWF) method to matrix product states, use a dynamic time-dependent variational principle (TDVP) to significantly reduce errors during time evolution, and introduce what we call a sampling MPS to drastically reduce the dependence on the simulation's time step size. We demonstrate that this method scales more effectively than previous methods and ensures convergence to the Lindbladian solution independent of system size, which we show both rigorously and numerically. Finally, we provide evidence of its utility by simulating Lindbladian dynamics of XXX Heisenberg models up to a thousand spins using a consumer-grade CPU. This work represents a significant step forward in the simulation of large-scale open quantum systems, with the potential to enable discoveries across various domains of quantum physics, particularly those where the environment plays a fundamental role, and to both dequantize and facilitate the development of more stable quantum hardware., Comment: 24 pages, 13 figures, 1 table (includes Methods and Appendix)
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- 2025
6. Derivation of a Multiscale Ferrofluid Model: Superparamagnetic Behavior due to Fast Spin Flip
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Girodoux-Lavigne, Alexandre and Höfer, Richard M.
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Mathematics - Analysis of PDEs - Abstract
We consider a microscopic model of $N$ magnetic nanoparticles in a Stokes flow. We assume that the temperature is above the critical N\'eel temperature such that the particles' magnetizations undergo random flip with rate $1/\varepsilon$. The microscopic system is the modeled through a piecewise deterministic Markov jump process. We show that for large $N$, small particle volume fraction and small $\varepsilon$, the system can be effectively described by a multiscale model.
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- 2025
7. Intensity Interferometer Results on Sirius with 0.25 m Telescopes
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Mozdzen, Thomas J., Scott, Richard M., Rodriguez, Ricardo R., and Mauskopf, Philip D.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the successful measurement of the squared visibility of Sirius at a telescope separation of 3.3 m using small 0.25 m Newtonian-style telescopes in an urban backyard setting. The primary science goal for small-scale intensity interferometers has been to measure the angular diameters of stars. Recent advances in low jitter time-tagging equipment and Single Photon Avalanche Detectors have made the detection of second-order photon correlation signals feasible with small low-cost telescopes. Using Sirius as a target star, we observe a photon count rate of $\sim$1.9 Mcps per detector with matched 1.2 nm wide filters at 589.3 nm and measured the spatial squared visibility at a telescope separation of 3.3 m to be $|V_{12}(3.3\text{m})|^2 = 0.94\pm0.16$. The measured detection significance is $\sim7 \sigma$ after 13.55 h of integration. The uncertainty in the measured visibility includes uncertainty in the instrument response function.The squared visibility agrees closely with the expected value of $0.94\pm0.01$. These results demonstrate that using small low-cost telescopes is feasible for intensity interferometry of bright stars. This enables a simple scaling in sensitivity by further realistic improvements in the instrument response jitter as well as increasing both the number of spectral bands and the number of telescopes towards systems capable of resolving objects such as quasars, white dwarfs, and galactic Cepheid variable stars.
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- 2025
8. Energy density and stress fields in quantum systems
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Martin, Richard M., Chetty, Nithaya, and Trinkle, Dallas R.
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Condensed Matter - Materials Science ,Condensed Matter - Other Condensed Matter - Abstract
There has been an enduring interest and controversy about whether or not one can define physically meaningful energy density and stress fields, $e({\bf r})$ and $\sigma_{\alpha \beta}({\bf r})$ in quantum systems. A key issue is kinetic energy since $\frac{1}{2}|\nabla \Psi|^2$ and $-\frac{1}{2}\Psi\nabla^2 \Psi$ lead to different densities, and analogous issues arise interaction energies. This paper presents a resolution to the problems in two steps: 1) All effects of exchange and correlation are shown to be unique functions defined at each point ${\bf r}$; all issues of non-uniqueness involve only the density $n({\bf r})$ and are equivalent to a single-particle problem with wavefunction $s({\bf r}) = \sqrt{n({\bf r})/N}$. 2) Forms for the latter terms are proposed based on the nature of energy and stress, where energy has two distinct roles. Because the energy determines the ground state itself through the variational principle, the appropriate density involves the terms in the hamiltonian: $-\frac{1}{2}\Psi\nabla^2 \Psi$ and interactions in terms of potentials acting on the particles. This leads naturally to density functional theory with the interpretation that the energy density $e({\bf r})$ is equilibrated to minimize fluctuations with the same chemical potential throughout the system. On the other hand, the energy and stress (derivative of the energy with respect to strain) are properties of the ground state, and simple examples to show that the only acceptable expressions involve the combination $\frac{1}{4}[|\nabla \Psi|^2 - \Psi\nabla^2 \Psi]$, as derived by Schrodinger, Pauli and others, and Coulomb interactions in the Maxwell form in terms of electric fields, not potentials. Together these results lead to well-defined formulations of energy density and stress fields that are physically motivated and based on a clear set of arguments.
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- 2025
9. A flux-limited sample of dusty star-forming galaxies from the Atacama Cosmology Telescope: physical properties and the case for multiplicity
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Hall, Kirsten R., Hassan, Jake, Feder, Richard M., Marriage, Tobias A., and Zemcov, Michael
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Astrophysics - Astrophysics of Galaxies - Abstract
We report the modeling of the millimeter and far-infrared spectral energy distributions of 71 dusty star-forming galaxies (DSFGs) selected by the Atacama Cosmology Telescope (ACT) with a lower flux-density limit of 8 mJy at 220 GHz (1.4 mm). All sources were cross-identified with Herschel surveys at 500, 350, and 250 {\mu}m, and nineteen of our sources were observed at with the Submillimeter Array. A probabilistic cataloging algorithm, PCAT, favors multiple unresolved flux components in the Herschel data for the majority of ACT-selected DSFGs. We compare the derived physical properties of the DSFGs obtained from modeling the flux densities with those from similar studies of both lensed and unlensed DSFG populations. We find the median, 16th and 84th percentiles for the following model parameters: redshift zphot=3.3(+0.7)(-0.6), apparent size {\mu}d=5.2(+0.9)(-2.4) kpc, apparent dust mass log10({\mu}Md/Msun)=9.14(+0.12)(-0.04) and cutoff temperature Tc=35.6(+4.8)(-1.6) K, and the corresponding apparent far-infrared luminosity log10({\mu}LIR/Lsun)=13.6(+0.2)(-0.3), where {\mu} is lensing magnification. While many of the properties broadly agree with those of samples of primarily lensed DSFGs, we exercise caution in interpreting them. ACT's lower flux limit, the PCAT decomposition, and the higher-resolution SMA observations all suggest that some fraction of these DSFGs are likely to be unlensed and possibly multiples. The SMA data indicate that at least fourteen out of nineteen sources are such, either via "missing" flux in comparison to the ensemble model or detection of additional sources in the fields. Additional high-resolution follow-up and targeted redshift observations are needed to better understand this flux-limited sample of DSFGs., Comment: 28 pages, 8 figures (26 including subfigures), submitted to ApJ
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- 2025
10. A Predefined-Time Convergent and Noise-Tolerant Zeroing Neural Network Model for Time Variant Quadratic Programming With Application to Robot Motion Planning
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Yang, Yi, Wang, Xuchen, Voyles, Richard M., and Ma, Xin
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Computer Science - Robotics ,Computer Science - Neural and Evolutionary Computing - Abstract
This paper develops a predefined-time convergent and noise-tolerant fractional-order zeroing neural network (PTC-NT-FOZNN) model, innovatively engineered to tackle time-variant quadratic programming (TVQP) challenges. The PTC-NT-FOZNN, stemming from a novel iteration within the variable-gain ZNN spectrum, known as FOZNNs, features diminishing gains over time and marries noise resistance with predefined-time convergence, making it ideal for energy-efficient robotic motion planning tasks. The PTC-NT-FOZNN enhances traditional ZNN models by incorporating a newly developed activation function that promotes optimal convergence irrespective of the model's order. When evaluated against six established ZNNs, the PTC-NT-FOZNN, with parameters $0 < \alpha \leq 1$, demonstrates enhanced positional precision and resilience to additive noises, making it exceptionally suitable for TVQP tasks. Thorough practical assessments, including simulations and experiments using a Flexiv Rizon robotic arm, confirm the PTC-NT-FOZNN's capabilities in achieving precise tracking and high computational efficiency, thereby proving its effectiveness for robust kinematic control applications., Comment: 14 pages, 4 figures; as accepted for publication
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- 2024
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11. Generalizable Representation Learning for fMRI-based Neurological Disorder Identification
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Cui, Wenhui, Akrami, Haleh, Joshi, Anand A., and Leahy, Richard M.
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computational Engineering, Finance, and Science ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Despite the impressive advances achieved using deep learning for functional brain activity analysis, the heterogeneity of functional patterns and the scarcity of imaging data still pose challenges in tasks such as identifying neurological disorders. For functional Magnetic Resonance Imaging (fMRI), while data may be abundantly available from healthy controls, clinical data is often scarce, especially for rare diseases, limiting the ability of models to identify clinically-relevant features. We overcome this limitation by introducing a novel representation learning strategy integrating meta-learning with self-supervised learning to improve the generalization from normal to clinical features. This approach enables generalization to challenging clinical tasks featuring scarce training data. We achieve this by leveraging self-supervised learning on the control dataset to focus on inherent features that are not limited to a particular supervised task and incorporating meta-learning to improve the generalization across domains. To explore the generalizability of the learned representations to unseen clinical applications, we apply the model to four distinct clinical datasets featuring scarce and heterogeneous data for neurological disorder classification. Results demonstrate the superiority of our representation learning strategy on diverse clinically-relevant tasks., Comment: arXiv admin note: substantial text overlap with arXiv:2312.14204
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- 2024
12. Detecting the Black Hole Candidate Population in M51's Young Massive Star Clusters: Constraints on Accreting Intermediate Mass Black Holes
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Dage, Kristen C., Tremou, Evangelia, Otahola, Bolivia Cuevas, Koch, Eric W., Oh, Kwangmin, Plotkin, Richard M., Tang, Vivian L., Aldhalemi, Muhammad Ridha, Bustani, Zainab, Fawaz, Mariam Ismail, Harff, Hans J., Khalyleh, Amna, McBride, Timothy, Mason, Jesse, Preston, Anthony, Rinehart, Cortney, Vinson, Ethan, Anderson, Gemma, Cackett, Edward M., Fu, Shih Ching, Kamann, Sebastian, Panurach, Teresa, Pechetti, Renuka, Saikia, Payaswini, Sett, Susmita, Urquhart, Ryan, and Usher, Christopher
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
Intermediate mass black holes (10^2 < M_BH< 10^5 Msun) are an open question in our understanding of black hole evolution and growth. They have long been linked to dense star cluster environments thanks to cluster dynamics, but there are a limited number of secure detections. We leverage existing X-ray observations from Chandra X-ray Observatory and optical catalogs from Hubble Space Telescope with new radio observations from the Karl G. Jansky Very Large Array to search for any evidence of accreting black holes in young massive clusters in the nearby galaxy M51. We find that of 43 bright ($L_X > 10^{38}$ erg/s) X-ray point sources in M51, 24 had probable matches to objects including possible associated star clusters in the HST Legacy Extragalactic UV Survey catalog, seven of which were classified as contaminants (background galaxies or foreground stars). We explore the optical properties of the remaining 17 sources, including cluster age and mass estimates, and search for radio counterparts in the 8-12 GHz band. The lack of radio counterparts to X-ray sources we know to be associated with young massive clusters in M51 suggests that we do not significantly detect hard-state IMBHs ~ 10^4 Msun or above. However, more sensitive radio facilities like the Square Kilometre Array and next generation Very Large Array may be able to provide evidence for IMBHs with masses down to ~ 10^3 Msun., Comment: 18 pages, 7 figures, accepted to ApJ
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- 2024
13. Chromatin remodeler CHD4 establishes chromatin states required for ovarian reserve formation, maintenance and male germ cell survival
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Munakata, Yasuhisa, Hu, Mengwen, Kitamura, Yuka, Dani, Raissa G, Bynder, Adam L, Fritz, Amelia S, Schultz, Richard M, and Namekawa, Satoshi H
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Biochemistry and Cell Biology ,Biological Sciences ,Genetics ,Infertility ,Contraception/Reproduction ,1.1 Normal biological development and functioning ,Reproductive health and childbirth ,Animals ,Female ,Male ,Chromatin ,Mice ,Mi-2 Nucleosome Remodeling and Deacetylase Complex ,Cell Survival ,Chromatin Assembly and Disassembly ,Oocytes ,Ovarian Reserve ,Spermatozoa ,Apoptosis ,Mice ,Knockout ,Meiosis ,DNA Helicases ,Environmental Sciences ,Information and Computing Sciences ,Developmental Biology ,Biological sciences ,Chemical sciences ,Environmental sciences - Abstract
The ovarian reserve defines female reproductive lifespan, which in humans spans decades due to the maintenance of meiotic arrest in non-growing oocytes (NGOs) residing in primordial follicles. Unknown is how the chromatin state of NGOs is established to enable long-term maintenance of the ovarian reserve. Here, we show that a chromatin remodeler, CHD4, a member of the Nucleosome Remodeling and Deacetylase (NuRD) complex, establishes chromatin states required for formation and maintenance of the ovarian reserve. Conditional loss of CHD4 in perinatal mouse oocytes results in acute death of NGOs and depletion of the ovarian reserve. CHD4 establishes closed chromatin at regulatory elements of pro-apoptotic genes to prevent cell death and at specific genes required for meiotic prophase I to facilitate the transition from meiotic prophase I oocytes to meiotically-arrested NGOs. In male germ cells, CHD4 establishes closed chromatin at the regulatory elements of pro-apoptotic genes, allowing germ cell survival. These results demonstrate a role for CHD4 in defining a chromatin state that ensures germ cell survival, thereby enabling the long-term maintenance of both female and male germ cells.
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- 2025
14. The single-cell opioid responses in the context of HIV (SCORCH) consortium
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Ament, Seth A, Campbell, Rianne R, Lobo, Mary Kay, Receveur, Joseph P, Agrawal, Kriti, Borjabad, Alejandra, Byrareddy, Siddappa N, Chang, Linda, Clarke, Declan, Emani, Prashant, Gabuzda, Dana, Gaulton, Kyle J, Giglio, Michelle, Giorgi, Federico M, Gok, Busra, Guda, Chittibabu, Hadas, Eran, Herb, Brian R, Hu, Wen, Huttner, Anita, Ishmam, Mohammad R, Jacobs, Michelle M, Kelschenbach, Jennifer, Kim, Dong-Wook, Lee, Cheyu, Liu, Shuhui, Liu, Xiaokun, Madras, Bertha K, Mahurkar, Anup A, Mash, Deborah C, Mukamel, Eran A, Niu, Meng, O’Connor, Richard M, Pagan, Chelsea M, Pang, Alina PS, Pillai, Piya, Repunte-Canonigo, Vez, Ruzicka, W Brad, Stanley, Jay, Tickle, Timothy, Tsai, Shang-Yi A, Wang, Allen, Wills, Lauren, Wilson, Alyssa M, Wright, Susan N, Xu, Siwei, Yang, Junchen, Zand, Maryam, Zhang, Le, Zhang, Jing, Akbarian, Schahram, Buch, Shilpa, Cheng, Christine S, Corley, Michael J, Fox, Howard S, Gerstein, Mark, Gummuluru, Suryaram, Heiman, Myriam, Ho, Ya-Chi, Kellis, Manolis, Kenny, Paul J, Kluger, Yuval, Milner, Teresa A, Moore, David J, Morgello, Susan, Ndhlovu, Lishomwa C, Rana, Tariq M, Sanna, Pietro Paolo, Satterlee, John S, Sestan, Nenad, Spector, Stephen A, Spudich, Serena, Tilgner, Hagen U, Volsky, David J, White, Owen R, Williams, Dionne W, and Zeng, Hongkui
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Pharmacology and Pharmaceutical Sciences ,Medical Microbiology ,Biomedical and Clinical Sciences ,HIV/AIDS ,Sexually Transmitted Infections ,Substance Misuse ,Opioids ,Opioid Misuse and Addiction ,Brain Disorders ,Drug Abuse (NIDA only) ,Neurosciences ,Infectious Diseases ,Behavioral and Social Science ,2.1 Biological and endogenous factors ,2.6 Resources and infrastructure (aetiology) ,Good Health and Well Being ,Animals ,Humans ,Analgesics ,Opioid ,Brain ,HIV Infections ,Opioid-Related Disorders ,Single-Cell Analysis ,Comorbidity ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of the seminal challenges in treating and studying addiction in human populations is the high prevalence of co-morbid conditions, including an increased risk of contracting a human immunodeficiency virus (HIV) infection. Of the ~15 million people who inject drugs globally, 17% are persons with HIV. Conversely, HIV is a risk factor for SUD because chronic pain syndromes, often encountered in persons with HIV, can lead to an increased use of opioid pain medications that in turn can increase the risk for opioid addiction. We hypothesize that SUD and HIV exert shared effects on brain cell types, including adaptations related to neuroplasticity, neurodegeneration, and neuroinflammation. Basic research is needed to refine our understanding of these affected cell types and adaptations. Studying the effects of SUD in the context of HIV at the single-cell level represents a compelling strategy to understand the reciprocal interactions among both conditions, made feasible by the availability of large, extensively-phenotyped human brain tissue collections that have been amassed by the Neuro-HIV research community. In addition, sophisticated animal models that have been developed for both conditions provide a means to precisely evaluate specific exposures and stages of disease. We propose that single-cell genomics is a uniquely powerful technology to characterize the effects of SUD and HIV in the brain, integrating data from human cohorts and animal models. We have formed the Single-Cell Opioid Responses in the Context of HIV (SCORCH) consortium to carry out this strategy.
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- 2024
15. How long is long enough? Finite-horizon approximation of energy storage scheduling problems
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Prat, Eléa, Lusby, Richard M., Morales, Juan Miguel, Pineda, Salvador, and Pinson, Pierre
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Mathematics - Optimization and Control - Abstract
Energy storage scheduling problems, where a storage is operated to maximize its profit in response to a price signal, are essentially infinite-horizon optimization problems as storage systems operate continuously, without a foreseen end to their operation. Such problems can be solved to optimality with a rolling-horizon approach, provided that the planning horizon over which the problem is solved is long enough. Such a horizon is termed a forecast horizon. However, the length of the planning horizon is usually chosen arbitrarily for such applications. We introduce an easy-to-check condition that confirms whether a planning horizon is a forecast horizon, and which can be used to derive a bound on suboptimality when it is not the case. By way of an example, we demonstrate that the existence of forecast horizons is not guaranteed for this problem. We also derive a lower bound on the length of the minimum forecast horizon. We show how the condition introduced can be used as part of an algorithm to determine the minimum forecast horizon of the problem, which ensures the determination of optimal solutions at the lowest computational and forecasting costs. Finally, we provide insights into the implications of different planning horizons for a range of storage system characteristics.
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- 2024
16. Locality and Conserved Charges in $T\overline{T}$-Deformed CFTs
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Monten, Ruben, Myers, Richard M., and Roumpedakis, Konstantinos
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High Energy Physics - Theory - Abstract
We investigate the locality properties of $T \overline T$-deformed CFTs within perturbation theory. Up to third order in the deformation parameter, we find a Hamiltonian operator which solves the flow equation, reproduces the Zamolodchikov energy spectrum, and is consistent with quasi-locality of the theory. This Hamiltonian includes terms proportional to the central charge which have not appeared before and which are necessary to reproduce the correct spectrum. We show that the Hamiltonian is not uniquely defined since it contains free parameters, starting at second order, which do not spoil the above properties. We then use it to determine the full conserved stress tensor. In our approach, the KdV charges are automatically conserved to all orders but are not a priori local. Nevertheless, we show that they can be made local to first order. Our techniques allow us to further comment on the space of Hamiltonians constructed from products of KdV charges which also flow to local charges in the deformed theory in the IR., Comment: 24 pages
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- 2024
17. Assessment of Misspecification in CDMs Using a Generalized Information Matrix Test
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Hosseinpourkhoshkbari, Reyhaneh and Golden, Richard M.
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Statistics - Methodology ,Mathematics - Statistics Theory - Abstract
If the probability model is correctly specified, then we can estimate the covariance matrix of the asymptotic maximum likelihood estimate distribution using either the first or second derivatives of the likelihood function. Therefore, if the determinants of these two different covariance matrix estimation formulas differ this indicates model misspecification. This misspecification detection strategy is the basis of the Determinant Information Matrix Test ($GIMT_{Det}$). To investigate the performance of the $GIMT_{Det}$, a Deterministic Input Noisy And gate (DINA) Cognitive Diagnostic Model (CDM) was fit to the Fraction-Subtraction dataset. Next, various misspecified versions of the original DINA CDM were fit to bootstrap data sets generated by sampling from the original fitted DINA CDM. The $GIMT_{Det}$ showed good discrimination performance for larger levels of misspecification. In addition, the $GIMT_{Det}$ did not detect model misspecification when model misspecification was not present and additionally did not detect model misspecification when the level of misspecification was very low. However, the $GIMT_{Det}$ discrimation performance was highly variable across different misspecification strategies when the misspecification level was moderately sized. The proposed new misspecification detection methodology is promising but additional empirical studies are required to further characterize its strengths and limitations.
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- 2024
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18. Do Neutron Star Ultra-Luminous X-Ray Sources Masquerade as Intermediate Mass Black Holes in Radio and X-Ray?
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Panurach, Teresa, Dage, Kristen C., Urquhart, Ryan, Plotkin, Richard M., Paul, Jeremiah D., Bahramian, Arash, Brumback, McKinley C., Galvin, Timothy J., Molina, Isabella, Miller-Jones, James C. A., and Saikia, Payaswini
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Ultraluminous X-ray sources (ULXs) were once largely believed to be powered by super-Eddington accretion onto stellar-mass black holes, although in some rare cases, ULXs also serve as potential candidates for (sub-Eddington) intermediate mass black holes. However, a total of eight ULXs have now been confirmed to be powered by neutron stars, thanks to observed pulsations, and may act as contaminants for radio/X-ray selection of intermediate mass black holes. Here we present the first comprehensive radio study of seven known neutron star ULXs using new and archival data from the Karl G. Jansky Very Large Array and the Australia Telescope Compact Array, combined with the literature. Across this sample there is only one confident radio detection, from the Galactic neutron star ULX Swift J0243.6+6124. The other six objects in our sample are extragalactic, and only one has coincident radio emission, which we conclude is most likely contamination from a background HII region. We conclude that with current facilities, neutron star ULXs do not produce significant enough radio emission to cause them to be misidentified as radio/X-ray selected intermediate mass black hole candidates. Thus, if background star formation has been properly considered, the current study indicates that a ULX with a compact radio counterpart is not likely to be a neutron star., Comment: 14 pages, 2 figures, accepted to ApJ
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- 2024
19. RingSim- An Agent-based Approach for Modelling Mesoscopic Magnetic Nanowire Networks
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Vidamour, Ian T, Venkat, Guru, Swindells, Charles, Griffin, David, Fry, Paul W, Rowan-Robinson, Richard M, Welbourne, Alexander, Maccherozzi, Francesco, Dhesi, Sarnjeet S, Stepney, Susan, Allwood, Dan A, and Hayward, Thomas J
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We describe 'RingSim', a phenomenological agent-based model that allows numerical simulation of magnetic nanowire networks with areas of hundreds of micrometers squared for durations of hundreds of seconds; a practical impossibility for general-purpose micromagnetic simulation tools. In RingSim, domain walls (DWs) are instanced as mobile agents which respond to external magnetic fields, and their stochastic interactions with pinning sites and other DWs are described via simple phenomenological rules. We first present a detailed description of the model and its algorithmic implementation for simulating the behaviours of arrays of interconnected ring-shaped nanowires, which have previously been proposed as hardware platforms for unconventional computing applications. The model is then validated against a series of experimental measurements of an array's static and dynamic responses to rotating magnetic fields. The robust agreement between the modelled and experimental data demonstrates that agent-based modelling is a powerful tool for exploring mesoscale magnetic devices, enabling time scales and device sizes that are inaccessible to more conventional magnetic simulation techniques.
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- 2024
20. Fractional-order spike-timing-dependent gradient descent for multi-layer spiking neural networks
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Yang, Yi, Voyles, Richard M., Zhang, Haiyan H., and Nawrocki, Robert A.
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Computer Science - Neural and Evolutionary Computing ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Accumulated detailed knowledge about the neuronal activities in human brains has brought more attention to bio-inspired spiking neural networks (SNNs). In contrast to non-spiking deep neural networks (DNNs), SNNs can encode and transmit spatiotemporal information more efficiently by exploiting biologically realistic and low-power event-driven neuromorphic architectures. However, the supervised learning of SNNs still remains a challenge because the spike-timing-dependent plasticity (STDP) of connected spiking neurons is difficult to implement and interpret in existing backpropagation learning schemes. This paper proposes a fractional-order spike-timing-dependent gradient descent (FO-STDGD) learning model by considering a derived nonlinear activation function that describes the relationship between the quasi-instantaneous firing rate and the temporal membrane potentials of nonleaky integrate-and-fire neurons. The training strategy can be generalized to any fractional orders between 0 and 2 since the FO-STDGD incorporates the fractional gradient descent method into the calculation of spike-timing-dependent loss gradients. The proposed FO-STDGD model is tested on the MNIST and DVS128 Gesture datasets and its accuracy under different network structure and fractional orders is analyzed. It can be found that the classification accuracy increases as the fractional order increases, and specifically, the case of fractional order 1.9 improves by 155% relative to the case of fractional order 1 (traditional gradient descent). In addition, our scheme demonstrates the state-of-the-art computational efficacy for the same SNN structure and training epochs., Comment: 15 pages, 12 figures
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- 2024
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21. Improved Velocity-Verlet Algorithm for the Discrete Element Method
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Vyas, Dhairya R., Ottino, Julio M., Lueptow, Richard M., and Umbanhowar, Paul B.
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Physics - Computational Physics - Abstract
The Discrete Element Method is widely employed for simulating granular flows, but conventional integration techniques may produce unphysical results for simulations with static friction when particle size ratios exceed $R \approx 3$. These inaccuracies arise because some variables in the velocity-Verlet algorithm are calculated at the half-timestep, while others are computed at the full timestep. To correct this, we develop an improved velocity-Verlet integration algorithm to ensure physically accurate outcomes up to the largest size ratios examined ($R=100$). The implementation of this improved integration method within the LAMMPS framework is detailed, and its effectiveness is validated through a simple three-particle test case and a more general example of granular flow in mixtures with large size-ratios, for which we provide general guidelines for selecting simulation parameters and accurately modeling inelasticity in large particle size-ratio simulations.
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- 2024
22. MAVIS: Enabling High-Precision Ground-Based Astrometry in the Visible Spectrum
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Taheri, Mojtaba, Cranney, Jesse, Marasco, Antonino, Monty, Stephanie, Massari, Davide, Agapito, Guido, Cresci, Giovanni, McDermid, Richard M., Rigaut, Francois, Neichel, Benoit, Brodrick, David, and Plantet, Cédric
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
MAVIS (the MCAO-Assisted Visible Imager and Spectrograph), planned for the VLT Adaptive Optics Facility, represents an innovative step in Multi-Conjugate Adaptive Optics (MCAO) systems, particularly in its operation at visible wavelengths and anticipated contributions to the field of astronomical astrometry. Recognizing the crucial role of high-precision astrometry in realizing science goals such as studying the dynamics of dense starfields, this study focuses on the challenges of advancing astrometry with MAVIS to its limits, as well as paving the way for further enhancement by incorporating telemetry data as part of the astrometric analysis. We employ MAVISIM, Superstar, and DAOPHOT to simulate both MAVIS imaging performance and provide a pathway to incorporate telemetry data for precise astrometry with MAVIS. Photometry analyses are conducted using the Superstar and DAOPHOT platforms, integrated into a specifically designed pipeline for astrometric analysis in MCAO settings. Combining these platforms, our research aims to elucidate the impact of utilizing telemetry data on improving astrometric precision, potentially establishing new methods for ground-based AO-assisted astrometric analysis. This endeavor not only sheds light on the capabilities of MAVIS but also paves the way for advancing astrometry in the era of next-generation MCAO-enabled giant telescopes.
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- 2024
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23. Granular segregation across flow geometries: a closure model for the particle segregation velocity
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Duan, Yifei, Jing, Lu, Umbanhowar, Paul B., Ottino, Julio M., and Lueptow, Richard M.
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Condensed Matter - Soft Condensed Matter - Abstract
Predicting particle segregation has remained challenging due to the lack of a general model for the segregation velocity that is applicable across a range of granular flow geometries. Here, a segregation velocity model for dense granular flows is developed by exploiting momentum balance and recent advances in particle-scale modelling of the segregation driving and drag forces over a wide range of particle concentrations, size and density ratios, and flow conditions. This model is shown to correctly predict particle segregation velocity in a diverse set of idealized and natural granular flow geometries simulated using the discrete element method. When incorporated in the well-established advection-diffusion-segregation formulation, the model has the potential to accurately capture segregation phenomena in many relevant industrial application and geophysical settings.
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- 2024
24. Correction to Doi type models for suspensions
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Gérard-Varet, David and Höfer, Richard M.
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Mathematics - Analysis of PDEs ,Mathematics - Probability - Abstract
Starting from microscopic $N$ particle systems, we study the derivation of Doi type models for suspensions of non-spherical particles in Stokes flows. While Doi models accurately describe the effective evolution of the spatial particle density to the first order in the particle volume fraction, this accuracy fails regarding the evolution of the particle orientations. We rigorously attribute this failure to the singular interaction of the particles via a $-3$-homogeneous kernel. In the situation that the particles are initially distributed according to a stationary ergodic point process, we identify the limit of this singular interaction term. It consists of two parts. The first corresponds to a classical term in Doi type models. The second new term depends on the (microscopic) $2$-point correlation of the point process. By including this term, we provide a modification of the Doi model that is accurate to first order in the particle volume fraction.
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- 2024
25. Lift Force on a Moving Intruder in Granular Shear Flow
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He, Hantao, Zhang, Qiong, Ottino, Julio M., Umbanhowar, Paul B., and Lueptow, Richard M.
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Condensed Matter - Soft Condensed Matter ,Physics - Fluid Dynamics - Abstract
Lift and drag forces on moving intruders in granular materials are of fundamental interest. While the drag force on an intruder in granular flow has been studied, the few studies characterizing the lift force explore a relatively limited range of parameters. Here we use discrete element method (DEM) simulations to measure the lift force, $F_\mathrm{L}$, on a spherical intruder in a uniformly sheared bed of smaller spheres for a range of intruder slip velocities, $u_\mathrm{s}$, relative to the unperturbed flow. In what at first appears as a puzzling result, $F_\mathrm{L}$ in granular shear flow acts in the opposite direction to the Saffman lift force on a sphere in a sheared fluid at low $u_\mathrm{s}$, reaches a maximum value, and then decreases, eventually reversing direction and becoming comparable to $F_\mathrm{L}$ for a fluid. This non-monotonic response holds over a range of flow conditions, and the $F_\mathrm{L}$ versus $u_\mathrm{s}$ data can be collapsed by scaling both quantities using the particle sizes, shear rate, and overburden pressure. Analogous fluid simulations demonstrate that the flow field around the intruder particle is similar in the granular and fluid cases. However, the shear stress acting on the intruder in a granular shear flow is much less than that in a fluid shear flow. This difference, combined with a void region behind the intruder in granular flow, which alters the pressure and shear stress on the trailing side of the intruder, significantly changes the lift-force inducing stresses acting on the intruder between the granular and fluid cases., Comment: 27 pages, 17 figures
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- 2024
26. Pulling back the curtain on shocks and star-formation in NGC 1266 with Gemini-NIFS
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Otter, Justin Atsushi, Alatalo, Katherine, Rowlands, Kate, McDermid, Richard M., Davis, Timothy A., Federrath, Christoph, French, K. Decker, Heckman, Timothy, Ogle, Patrick, Kakkad, Darshan, Luo, Yuanze, Nyland, Kristina, Tripathi, Akshat, Patil, Pallavi, Petric, Andreea, Smercina, Adam, Skarbinski, Maya, Lanz, Lauranne, Larson, Kristin, Appleton, Philip N., Aalto, Susanne, Olander, Gustav, Sazonova, Elizaveta, and Smith, J. D. T.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present Gemini near-infrared integral field spectrograph (NIFS) K-band observations of the central 400 pc of NGC 1266, a nearby (D$\approx$30 Mpc) post-starburst galaxy with a powerful multi-phase outflow and a shocked ISM. We detect 7 H$_2$ ro-vibrational emission lines excited thermally to $T$$\sim$2000 K, and weak Br$\gamma$ emission, consistent with a fast C-shock. With these bright H$_2$ lines, we observe the spatial structure of the shock with an unambiguous tracer for the first time. The Br$\gamma$ emission is concentrated in the central $\lesssim$100 pc, indicating that any remaining star-formation in NGC 1266 is in the nucleus while the surrounding cold molecular gas has little on-going star-formation. Though it is unclear what fraction of this Br$\gamma$ emission is from star-formation or the AGN, assuming it is entirely due to star-formation we measure an instantaneous star-formation rate of 0.7 M$_\odot$ yr$^{-1}$, though the star-formation rate may be significantly higher in the presence of additional extinction. NGC 1266 provides a unique laboratory to study the complex interactions between AGN, outflows, shocks, and star-formation, all of which are necessary to unravel the evolution of the post-starburst phase., Comment: ApJ accepted
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- 2024
27. Three Approaches to the Automation of Laser System Alignment and Their Resource Implications: A Case Study
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Robb, David A., Risbridger, Donald, Mills, Ben, Rakhmatulin, Ildar, Kong, Xianwen, Erden, Mustafa, Esser, M. J. Daniel, Carter, Richard M., and Chantler, Mike J.
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Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Machine Learning ,Computer Science - Robotics - Abstract
The alignment of optical systems is a critical step in their manufacture. Alignment normally requires considerable knowledge and expertise of skilled operators. The automation of such processes has several potential advantages, but requires additional resource and upfront costs. Through a case study of a simple two mirror system we identify and examine three different automation approaches. They are: artificial neural networks; practice-led, which mimics manual alignment practices; and design-led, modelling from first principles. We find that these approaches make use of three different types of knowledge 1) basic system knowledge (of controls, measurements and goals); 2) behavioural skills and expertise, and 3) fundamental system design knowledge. We demonstrate that the different automation approaches vary significantly in human resources, and measurement sampling budgets. This will have implications for practitioners and management considering the automation of such tasks., Comment: Author Accepted Manuscript- 8 pages, The 2024 IEEE 20th International Conference on Automation Science and Engineering (CASE 2024), Aug28-Sep1st 2024, Bari, Italy. Keywords: Automation, optimisation, regression, behaviour analysis, artificial neural networks, optical systems, mathematical model, human factors, sampling cost, cost benefit analysis
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- 2024
28. Optimal Operation of a Building with Electricity-Heat Networks and Seasonal Storage
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Prat, Eléa, Pinson, Pierre, Lusby, Richard M., Plougonven, Riwal, Badosa, Jordi, and Drobinski, Philippe
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Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
As seasonal thermal energy storage emerges as an efficient solution to reduce CO2 emissions of buildings, challenges appear related to its optimal operation. In a system including short-term electricity storage, long-term heat storage, and where electricity and heat networks are connected through a heat pump, it becomes crucial to operate the system on two time scales. Based on real data from a university building, we simulate the operation of such a system over a year, comparing different strategies based on model predictive control (MPC). The first objective of this paper is to determine the minimum prediction horizon to retrieve the results of the full-horizon operation problem with cost minimization. The second objective is to evaluate a method that combines MPC with setting targets on the heat storage level at the end of the prediction horizon, based on historical data. For a prediction horizon of 6 days, the suboptimality gap with the full-horizon results is 4.31%, compared to 11.42% when using a prediction horizon of 42 days and fixing the final level to be equal to the initial level, which is a common approach.
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- 2024
29. The MAGPI Survey: Orbital distributions, intrinsic shapes, and mass profiles for MAGPI-like Eagle galaxies using Schwarzschild dynamical models
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Santucci, Giulia, Lagos, Claudia Del P., Harborne, Katherine E., Derkenne, Caro, Poci, Adriano, Thater, Sabine, McDermid, Richard M., Mendel, J. Trevor, Wisnioski, Emily, Croom, Scott M., Ferré-Mateu, Anna, Muller, Eric G. M., van de Sande, Jesse, Sharma, Gauri, Sweet, Sarah M., Tsukui, Takafumi, Valenzuela, Lucas M., van de Ven, Glenn, and Zafar, Tayyaba
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Astrophysics - Astrophysics of Galaxies - Abstract
Schwarzschild dynamical models are now regularly employed in large surveys of galaxies in the local and distant Universe to derive information on galaxies' intrinsic properties such as their orbital structure and their (dark matter and stellar) mass distribution. Comparing the internal orbital structures and mass distributions of galaxies in the distant Universe with simulations is key to understanding what physical processes are responsible for shaping galaxy properties. However it is first crucial to understand whether observationally derived properties are directly comparable with intrinsic ones in simulations. To assess this, we build Schwarzschild dynamical models for MUSE-like IFS cubes (constructed to be like those obtained by the MAGPI survey) of 75 galaxies at z ~ 0.3 from the Eagle simulations. We compare the true particle-derived properties with the galaxies' model-derived properties. In general, we find that the models can recover the true galaxy properties qualitatively well, with the exception of the enclosed dark matter, where we find a median offset of 48%, which is due to the assumed NFW profile not being able to reproduce the dark matter distribution in the inner region of the galaxies. We then compare our model-derived properties with Schwarzschild models-derived properties of observed MAGPI galaxies and find good agreement between MAGPI and Eagle: the majority of our galaxies (57%) have non-oblate shapes within 1 effective radius. More triaxial galaxies show higher fractions of hot orbits in their inner regions and tend to be more radially anisotropic., Comment: 22 pages. Accepted for publication in MNRAS
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- 2024
30. Diffusion-limited settling of highly porous particles in density-stratified fluids
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Hunt, Robert, Camassa, Roberto, McLaughlin, Richard M., and Harris, Daniel M.
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Physics - Fluid Dynamics - Abstract
The vertical transport of solid material in a stratified medium is fundamental to a number of environmental applications, with implications for the carbon cycle and nutrient transport in marine ecosystems. In this work, we study the diffusion-limited settling of highly porous particles in a density-stratified fluid through a combination of experiment, analysis, and numerical simulation. By delineating and appealing to the diffusion-limited regime wherein buoyancy effects due to mass adaptation dominate hydrodynamic drag, we derive a simple expression for the steady settling velocity of a sphere as a function of the density, size, and diffusivity of the solid, as well as the density gradient of the background fluid. In this regime, smaller particles settle faster, in contrast with most conventional hydrodynamic drag mechanisms. Furthermore, we outline a general mathematical framework for computing the steady settling speed of a body of arbitrary shape in this regime and compute exact results for the case of general ellipsoids. Using hydrogels as a highly porous model system, we validate the predictions with laboratory experiments in linear stratification for a wide range of parameters. Lastly, we show how the predictions can be applied to arbitrary slowly varying background density profiles and demonstrate how a measured particle position over time can be used to reconstruct the background density profile.
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- 2024
31. Study of CG0070 Combined With Nivolumab in Cisplatin Ineligible Patients With MIBC
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CG Oncology, Inc. and Richard M. Shulze Family Foundation
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- 2024
32. From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study
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Vassy, Jason L, Dornisch, Anna M, Karunamuni, Roshan, Gatzen, Michael, Kachulis, Christopher J, Lennon, Niall J, Brunette, Charles A, Danowski, Morgan E, Hauger, Richard L, Garraway, Isla P, Kibel, Adam S, Lee, Kyung Min, Lynch, Julie A, Maxwell, Kara N, Rose, Brent S, Teerlink, Craig C, Xu, George J, Hofherr, Sean E, Lafferty, Katherine A, Larkin, Katie, Malolepsza, Edyta, Patterson, Candace J, Toledo, Diana M, Donovan, Jenny L, Hamdy, Freddie, Martin, Richard M, Neal, David E, Turner, Emma L, Andreassen, Ole A, Dale, Anders M, Mills, Ian G, Batra, Jyotsna, Clements, Judith, Cussenot, Olivier, Cybulski, Cezary, Eeles, Rosalind A, Fowke, Jay H, Grindedal, Eli Marie, Hamilton, Robert J, Lim, Jasmine, Lu, Yong-Jie, MacInnis, Robert J, Maier, Christiane, Mucci, Lorelei A, Multigner, Luc, Neuhausen, Susan L, Nielsen, Sune F, Parent, Marie-Élise, Park, Jong Y, Petrovics, Gyorgy, Plym, Anna, Razack, Azad, Rosenstein, Barry S, Schleutker, Johanna, Sørensen, Karina Dalsgaard, Travis, Ruth C, Vega, Ana, West, Catharine ML, Wiklund, Fredrik, Zheng, Wei, Committee, Profile Steering, Committee and Collaborators, IMPACT Study Steering, Consortium, PRACTICAL, Program, Million Veteran, and Seibert, Tyler M
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Health Services and Systems ,Health Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Human Genome ,Urologic Diseases ,Prevention ,Prostate Cancer ,Health Services ,Cancer ,4.2 Evaluation of markers and technologies ,Good Health and Well Being - Abstract
ABSTRACT: Background: As healthcare moves from a one-size-fits-all approach towards precision care, individual risk prediction is an important step in disease prevention and early detection. Biobank-linked healthcare systems can generate knowledge about genomic risk and test the impact of implementing that knowledge in care. Risk-stratified prostate cancer screening is one clinical application that might benefit from such an approach. Methods: We developed a clinical translation pipeline for genomics-informed prostate cancer screening in a national healthcare system. We used data from 585,418 male participants of the Veterans Affairs (VA) Million Veteran Program (MVP), among whom 101,920 self-identify as Black/African-American, to develop and validate the Prostate CAncer integrated Risk Evaluation (P-CARE) model, a prostate cancer risk prediction model based on a polygenic score, family history, and genetic principal components. The model was externally validated in data from 18,457 PRACTICAL Consortium participants. A novel blended genome-exome (BGE) platform was used to develop a clinical laboratory assay for both the P-CARE model and rare variants in prostate cancer-associated genes, including additional validation in 74,331 samples from the All of Us Research Program. Results: In overall and ancestry-stratified analyses, the polygenic score of 601 variants was associated with any, metastatic, and fatal prostate cancer in MVP and PRACTICAL. Values of the P-CARE model at ≥80th percentile in the multiancestry cohort overall were associated with hazard ratios (HR) of 2.75 (95% CI 2.66-2.84), 2.78 (95% CI 2.54-2.99), and 2.59 (95% CI 2.22-2.97) for any, metastatic, and fatal prostate cancer in MVP, respectively, compared to the median. When high– and low-risk groups were defined as P-CARE HR>1.5 and HR
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- 2024
33. Natural Selection on HLA-DPB1 Amino Acids Operates Primarily on DP Serologic Categories
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Single, Richard M, Mack, Steven J, Solberg, Owen D, Thomson, Glenys, and Erlich, Henry A
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Biomedical and Clinical Sciences ,Immunology ,DPB1 ,Balancing selection ,DP serologic categories ,Amino acid ,Population study - Abstract
The DPB1 locus is notable among the classical HLA loci in that allele frequencies at this locus are consistent with genetic drift, whereas the frequencies of specific DPβ amino acids are consistent with the action of balancing selection. We investigated the influence of natural selection in shaping the diversity of three functional categories of DPB1 diversity defined by specific amino acid motifs, DPB1 T-cell epitopes, DPB1 supertypes and DP1-DP4 serologic categories (SCs), via Ewens-Watterson (EW) selective neutrality and asymmetric Linkage Disequilibrium (ALD) analyses in a worldwide sample of 136 populations. These EW analyses provide strong evidence for the operation of balancing selection on DP SCs, but no evidence for balancing selection on T-cell epitopes or supertypes. We further investigated the global distribution of SCs. Each SC is common in a different region of the world, with the DP1 SC most common in Southeast Asia and Oceania, the DP2 SC in North and South America, the DP3 SC in South America, and the DP4 SC in Europe. The DP2 SC is present in all populations, while 14% of populations are missing at least one DP1, DP3, or DP4 SC. We observed consistent DPA1∼DP SC haplotype associations across 10 populations from five global regions, and found that asymmetric linkage disequilibrium (LD) between the DPB1 locus and the four most-common DPA1 alleles (DPA1*01:03, *02:01, *02:02 and *03:01) is determined by variation at DPβ AA positions 85-87. These positions are in LD with both DPα positions 31 and 50. We conclude from these EW analyses that natural selection is primarily operating to maintain population-level diversity of DP SCs, rather than DPB1 alleles or other functional categories of DPB1 diversity.
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- 2024
34. Population Genetic Dissection of HLA-DPB1 Amino Acid Polymorphism to Infer Selection
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Mack, Steven J, Single, Richard M, Solberg, Owen D, Thomson, Glenys, and Erlich, Henry A
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Biomedical and Clinical Sciences ,Immunology ,Genetics ,Balancing selection ,Linkage disequilibrium ,Amino acid ,Population genetics ,HLA-DPB1 ,Humans ,Genetics ,Population ,Gene Frequency ,Linkage Disequilibrium ,Polymorphism ,Genetic ,Alleles ,Exons ,Selection ,Genetic ,HLA-DP beta-Chains - Abstract
Although allele frequency data for most HLA loci provide strong evidence for balancing selection at the allele level, the DPB1 locus is a notable exception, with allele frequencies compatible with neutral evolution (genetic drift) or directional selection in most populations. This discrepancy is especially interesting as evidence for balancing selection has been seen at the nucleotide and amino acid (AA) sequence levels for DPB1. We describe methods used to examine the global distribution of DPB1 alleles and their constituent AA sequences. These methods allow investigation of the influence of natural selection in shaping DPβ diversity in a hierarchical fashion for DPB1 alleles, all polymorphic DPB1 exon 2-encoded AA positions, as well as all pairs and trios of these AA positions. In addition, we describe how asymmetric linkage disequilibrium for all DPB1 exon 2-encoded AA pairs can be used to complement other methods. Application of these methods provides strong evidence for the operation of balancing selection on AA positions 56, 85-87, 36, 55 and 84 (listed in decreasing order of the strength of selection), but no evidence for balancing selection on DPB1 alleles.
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- 2024
35. Acute Implantation of a Bioresorbable Polymer Scaffold in Patients With Complete Thoracic Spinal Cord Injury: A Randomized Controlled Trial (INSPIRE 2.0).
- Author
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Harrop, James S, Kim, Kee D, Okonkwo, David O, Goldstein, Ira M, Lee, K Stuart, and Toselli, Richard M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Spinal Cord Injury ,Neurodegenerative ,Neurosciences ,Traumatic Head and Spine Injury ,Clinical Research ,Patient Safety ,Physical Injury - Accidents and Adverse Effects ,Clinical Trials and Supportive Activities ,Neurological ,Neurology & Neurosurgery ,Clinical sciences ,Biological psychology - Abstract
Background and objectivesTraumatic spinal cord injury (SCI) remains a devastating condition with no proven effective treatment options available. In a prior single-arm study of patients with thoracic complete SCI (INSPIRE; ClinicalTrials.gov, NCT02138110), acute implantation of an investigational bioresorbable polymer scaffold (Neuro-Spinal Scaffold [NSS]) appeared to be safe through 24 months postimplantation and was associated with an American Spinal Injury Association Impairment Scale (AIS) conversion rate that exceeded historical controls. Here, we evaluated whether NSS implantation demonstrates probable benefit for safety and neurological recovery in patients with thoracic complete SCI vs standard-of-care spine surgery.MethodsINSPIRE 2.0 was a randomized, controlled, parallel, multicenter study conducted at Level I trauma centers in the United States (ClinicalTrials.gov, NCT03762655; funded by InVivo Therapeutics Corporation). Patients with AIS grade A, thoracic (T2-T12), nonpenetrating SCI requiring spine surgery ≤7 days postinjury were randomized (1:1, computer-generated allocation) to undergo NSS implantation or spine surgery alone (control group). Patients and follow-up International Standards for Neurological Classification of SCI assessors were blinded. A predefined study success criterion required the proportion of patients with improvement of ≥1 AIS grade at 6 months postsurgery (primary endpoint) to be ≥20% higher in the NSS group than in the control group.ResultsTarget enrollment was reached (N = 20) with 10 patients randomized and analyzed in each group. At 6 months postsurgery, an improvement in the AIS grade was reported in 2 NSS patients (20%; both to AIS C) and 3 control group patients (30%; to AIS B [n = 2] or AIS C [n = 1]). No serious or unanticipated adverse device effects were reported. The study was closed to further follow-up because of not meeting its primary endpoint.ConclusionIn this small group of patients with thoracic complete (AIS A) SCI, implantation of an intraparenchymal bioresorbable scaffold did not produce probable clinical benefit. However, this study provides evidence that surgical intervention in an injured spinal cord parenchyma may be performed safely.
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- 2024
36. Optical bounds on many-electron localization
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Souza, Ivo, Martin, Richard M., and Stengel, Massimiliano
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Condensed Matter - Materials Science - Abstract
We establish rigorous inequalities between different electronic properties linked to optical sum rules, and organize them into weak and strong bounds on three characteristic properties of insulators: electron localization length $\ell$ (the quantum fluctuations in polarization), electric susceptibility $\chi$, and optical gap $E_{\rm G}$. All-electron and valence-only versions of the bounds are given, and the latter are found to be more informative. The bounds on $\ell$ are particularly interesting, as they provide reasonably tight estimates for an ellusive ground-state property -- the average localization length of valence electrons -- from tabulated experimental data: electron density, high-frequency dielectric constant, and optical gap. The localization lengths estimated in this way for several materials follow simple chemical trends, especially for the alkali halides. We also illustrate our findings via analytically solvable harmonic oscillator models, which reveal an intriguing connection to the physics of long-ranged van der Waals forces.
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- 2024
37. PyTreeNet: A Python Library for easy Utilisation of Tree Tensor Networks
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Milbradt, Richard M., Huang, Qunsheng, and Mendl, Christian B.
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Quantum Physics ,Condensed Matter - Strongly Correlated Electrons - Abstract
In recent years, tree tensor network methods have proven capable of simulating quantum many-body and other high-dimensional systems. This work is a user guide to our Python library PyTreeNet. It includes code examples and exercises to introduce the library's functions and familiarise the reader with the concepts and methods surrounding tree tensor networks. PyTreeNet implements all the tools required to implement general tree tensor network methods, such as tensor decompositions and arbitrary tree structures. The main focus is on the time evolution of quantum systems. This includes an introduction to tree tensor network states and operators and the time-evolving block decimation and time-dependent variational principle. The library's capabilities are showcased with the example of a modified transverse field Ising model on tree structures that go far beyond the ability of common state vector methods., Comment: (53 pages, 17 figures, code available at https://github.com/Drachier/PyTreeNet)
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- 2024
38. Carrollian Partition Functions and the Flat Limit of AdS
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Kraus, Per and Myers, Richard M.
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High Energy Physics - Theory - Abstract
The formulation of the S-matrix as a path integral with specified asymptotic boundary conditions naturally leads to the realization of a Carrollian partition function defined on the boundary of Minkowski space. This partition function, specified at past and future null infinity in the case of massless particles, generates Carrollian correlation functions that encode the S-matrix. We explore this connection, including the realization of symmetries, soft theorems arising from large gauge transformations, and the correspondence with standard momentum space amplitudes. This framework is also well-suited for embedding the Minkowski space S-matrix into the AdS/CFT duality in the large radius limit. In particular, we identify the AdS and Carrollian partition functions through a simple map between their respective asymptotic data, establishing a direct correspondence between the actions of symmetries on both sides. Our approach thus provides a coherent framework that ties together various topics extensively studied in recent and past literature., Comment: 59 pages; v2 corrected typos, added discussion of flat space Witten diagrams in section 3; v3 matches published version
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- 2024
39. Rest-Frame Optical Spectroscopy of Ten z $\sim$ 2 Weak Emission-Line Quasars
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Chen, Ying, Luo, Bin, Brandt, W. N., Zuo, Wenwen, Dix, Cooper, Ha, Trung, Matthews, Brandon, Paul, Jeremiah D., Plotkin, Richard M., and Shemmer, Ohad
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Astrophysics - Astrophysics of Galaxies - Abstract
We present near-infrared spectroscopy of ten weak emission-line quasars (WLQs) at redshifts of $z\sim2$, obtained with the Palomar 200-inch Hale Telescope. WLQs are an exceptional population of type 1 quasars that exhibit weak or no broad emission lines in the ultraviolet (e.g., the C IV $\lambda 1549$ line), and they display remarkable X-ray properties. We derive H$\beta$-based single-epoch virial black-hole masses (median value $\rm 1.7 \times 10^{9} M_{\odot}$) and Eddington ratios (median value $0.5)$ for our sources. We confirm the previous finding that WLQ H$\beta$ lines, as a major low-ionization line, are not significantly weak compared to typical quasars. The most prominent feature of the WLQ optical spectra is the universally weak/absent [O III] $\lambda 5007$ emission. They also display stronger optical Fe II emission than typical quasars. Our results favor the super-Eddington accretion scenario for WLQs, where the weak lines are a result of a soft ionizing continuum; the geometrically thick inner accretion disk and/or its associated outflow is responsible for obscuring the nuclear high-energy radiation and producing the soft ionizing continuum. We also report candidate extreme [O III] outflows (blueshifts of $\approx 500$ and $\rm 4900 km s^{-1}$) in one object., Comment: 19 pages, 8 figures, accepted for publication in ApJ
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- 2024
40. Analog Quantum Simulator of a Quantum Field Theory with Fermion-Spin Systems in Silicon
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Rad, Ali, Schuckert, Alexander, Crane, Eleanor, Nambiar, Gautam, Fei, Fan, Wyrick, Jonathan, Silver, Richard M., Hafezi, Mohammad, Davoudi, Zohreh, and Gullans, Michael J.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Simulating fermions coupled to spin degrees of freedom, relevant for a range of quantum field theories, represents a promising application for quantum simulators. Mapping fermions to qubits is challenging in $2+1$ and higher spacetime dimensions, and mapping bosons demands substantial quantum-computational overhead. These features complicate the realization of mixed fermion-boson quantum systems in digital quantum computers. We propose a native fermion-(large-)spin analog quantum simulator by utilizing dopant arrays in silicon. Specifically, we show how to use a dynamical lattice of coupled nuclear spins and conduction-band electrons to realize a quantum field theory: an extended Jackiw-Rebbi model involving coupled fermions and quantum rotors. We demonstrate the feasibility of observing dynamical mass generation and a confinement-deconfinement quantum phase transition in 1+1 dimensions on this platform, even in the presence of strong long-range Coulomb interactions. Furthermore, we employ finite-temperature Hartree-Fock-Bogoliubov simulations to investigate the dynamics of mass generation in two-dimensional square and honeycomb arrays, showing that this phenomenon can be simulated with realistic experimental parameters. Our findings reveal two distinct phases, and demonstrate robustness against the addition of Coulomb interactions. Finally, we discuss experimental signatures of the phases through transport and local charge sensing in dopant arrays. This study lays the foundation for quantum simulations of quantum field theories exhibiting fermions coupled to spin degrees of freedom using donors in silicon.
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- 2024
41. A multi-frequency spaceborne radar perspective of deep convection
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Chase, Randy J., Dolan, Brenda, Rasmussen, Kristen L., Schulte, Richard M., Stephens, Graeme, Turk, F. Joe, and Heever, Susan C. van den
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Physics - Atmospheric and Oceanic Physics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Global numerical weather models are starting to resolve atmospheric moist convection which comes with a critical need for observational constraints. One avenue for such constraints is spaceborne radar which tend to operate at three wavelengths, Ku-, Ka- and W-band. Many studies of deep convection in the past have primarily leveraged Ku-band because it is less affected by attenuation and multiple scattering. However, future spaceborne radar missions might not contain a Ku-band radar and thus considering the view of convection from Ka-band or W-band compared to the Ku-band would be useful. This study examines a coincident dataset between the Global Precipitation Measurement (GPM) Mission and CloudSat as well as the entire GPM record to compare convective characteristics across various wavelengths within deep convection. We find that W-band reflectivity (Z) tends to maximize near the Ku-band defined echo-top while Ka-band often maximizes 4-5 km below. The height of the maximum Z above the melting level for W-band does not linearly relate to the Ku-band maximum. However, using the full GPM record the Ka-band 30 dBZ echo-tops can be linearly related to the Ku-band 40 dBZ echo-top with an $R^2$ of 0.62 and a root mean squared error of about 1 km. The spatial distribution of echo-tops from Ka-band corresponds well to the Ku-band echo-tops, highlighting regions of relatively large ice water path. This paper suggests that Ka-band only missions, like NASA's Investigation for Convective Updrafts, should be able to characterize global convection in a similar manner to a Ku-band system.
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- 2024
42. Exceptionally Large Fluctuations in Orientational Order: The Lessons of Large-Deviation Theory for Liquid Crystalline Systems
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Mainas, Eleftherios and Stratt, Richard M.
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Condensed Matter - Soft Condensed Matter ,Physics - Chemical Physics - Abstract
How condensed-matter simulations depend on the number of molecules being simulated ($N$) is sometimes itself a valuable piece of information. Liquid crystals provide a case in point. Light scattering and $2d$-IR experiments on isotropic-phase samples display increasingly large orientational fluctuations ("pseudo-nematic domains") as the samples approach their nematic phase. The growing length scale of those locally ordered domains is readily seen in simulation as an ever-slower convergence of the distribution of orientational order parameters with $N$. But the rare-event character and exceptionally slow time scales of the largest fluctuations make them difficult to sample accurately. We show in this paper how taking a large-deviation-theory perspective enables us to leverage simulation-derived information more effectively. A key insight of the theory is that finding quantities such as orientational order parameters (extensive variables), is completely equivalent to deducing the conjugate (intensive) thermodynamic field required to equilibrate that amount of order - and that knowing the relationship between the two (the "equation of state") can easily be turned into knowing the relative free energy of that degree of order. A variety of well-known thermodynamic integration strategies are already founded on this idea, but instead of applying an artificially imposed external field, we use a priori statistical mechanical insights into the small and large-field limits to construct a simulation-guided, interpolated, equation of state. The free energies that result mostly need information from the most probable configurations, making the simulation process far more efficient than waiting for (or artificially generating) large fluctuations., Comment: 39 pages, 8 figures
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- 2024
43. The MAGPI Survey: Massive slow rotator population in place by $z \sim 0.3$
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Derkenne, Caro, McDermid, Richard M., D'Eugenio, Francesco, Foster, Caroline, Khalid, Aman, Harborne, Katherine E., van de Sande, Jesse, Croom, Scott M., Lagos, Claudia D. P., Bellstedt, Sabine, Mendel, J. Trevor, Mun, Marcie, Wisnioski, Emily, Bagge, Ryan S., Battisti, Andrew J., Bland-Hawthorn, Joss, Ferré-Mateu, Anna, Peng, Yingjie, Santucci, Giulia, Sweet, Sarah M., Thater, Sabine, Valenzuela, Lucas M., and Ziegler, Bodo
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Astrophysics - Astrophysics of Galaxies - Abstract
We use the `Middle Ages Galaxy Properties with Integral field spectroscopy' (MAGPI) survey to investigate whether galaxies have evolved in the distribution of their stellar angular momentum in the past 3-4 Gyr, as probed by the observational proxy for spin, $\lambda_{R}$. We use 2D stellar kinematics to measure $\lambda_{R}$ along with detailed photometric models to estimate galaxy ellipticity. The combination of these measurements quantifies the kinematic classes of `fast rotators' and the rarer `slow rotators', which show no regular rotation in their line-of-sight velocity fields. We compare 51 MAGPI galaxies with $\log_{10} (M_{\star}/\mathrm{M}_\odot) > 10$ to carefully drawn samples of MaNGA galaxies in the local Universe, selected to represent possible descendants of the MAGPI progenitors. The EAGLE simulations are used to identify possible evolutionary pathways between the two samples, explicitly accounting for progenitor bias in our results and the varied evolutionary pathways a galaxy might take between the two epochs. We find that the occurrence of slow rotating galaxies is unchanged between the MAGPI ($z \sim 0.3$) and MaNGA ($z \sim 0$) samples, suggesting the massive slow rotator population was already in place $\sim 4$ Gyr ago and has not accumulated since. There is a hint of the MAGPI sample having an excess of high $\lambda_{R}$ galaxies compared to the MaNGA sample, corresponding to more ordered rotation, but statistically the samples are not significantly different. The large-scale stellar kinematics, as quantified through the $\lambda_{R}$ parameter, of galaxies at $z \sim 0.3$ have already evolved into the diversity of structures seen today in the local Universe., Comment: 10 pages, 7 figures, accepted for publication in MNRAS
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- 2024
44. Defining a ‘cells to society’ research framework for appendiceal tumours
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Holowatyj, Andreana N., Overman, Michael J., Votanopoulos, Konstantinos I., Lowy, Andrew M., Wagner, Patrick, Washington, Mary K., Eng, Cathy, Foo, Wai Chin, Goldberg, Richard M., Hosseini, Mojgan, Idrees, Kamran, Johnson, Douglas B., Shergill, Ardaman, Ward, Erin, Zachos, Nicholas C., and Shelton, Deborah
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- 2025
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45. The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD)
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Moser, Othmar, Zaharieva, Dessi P., Adolfsson, Peter, Battelino, Tadej, Bracken, Richard M., Buckingham, Bruce A., Danne, Thomas, Davis, Elizabeth A., Dovč, Klemen, Forlenza, Gregory P., Gillard, Pieter, Hofer, Sabine E., Hovorka, Roman, Jacobs, Peter G., Mader, Julia K., Mathieu, Chantal, Nørgaard, Kirsten, Oliver, Nick S., O’Neal, David N., Pemberton, John, Rabasa-Lhoret, Rémi, Sherr, Jennifer L., Sourij, Harald, Tauschmann, Martin, Yardley, Jane E., and Riddell, Michael C.
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- 2025
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46. Analysis of scoliosis rod deformation after cutting with a surgical rod cutter
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Egan, James, Erickson, Collin T., Bennett, Kierstin, Tideman, Grace E., Schwend, Richard M., Friis, Elizabeth A., and Anderson, John T.
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- 2025
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47. Risk of Lymph Node Metastasis in T2 Colon Cancer: A Nationwide Population-Based Cohort Study
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Hanevelt, Julia, Brohet, Richard M., Moons, Leon M. G., Laclé, Miangela M., Vleggaar, Frank P., van Westreenen, Henderik L., and de Vos Tot Nederveen Cappel, Wouter H.
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- 2025
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48. Genomics yields biological and phenotypic insights into bipolar disorder
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O’Connell, Kevin S., Koromina, Maria, van der Veen, Tracey, Boltz, Toni, David, Friederike S., Yang, Jessica Mei Kay, Lin, Keng-Han, Wang, Xin, Coleman, Jonathan R. I., Mitchell, Brittany L., McGrouther, Caroline C., Rangan, Aaditya V., Lind, Penelope A., Koch, Elise, Harder, Arvid, Parker, Nadine, Bendl, Jaroslav, Adorjan, Kristina, Agerbo, Esben, Albani, Diego, Alemany, Silvia, Alliey-Rodriguez, Ney, Als, Thomas D., Andlauer, Till F. M., Antoniou, Anastasia, Ask, Helga, Bass, Nicholas, Bauer, Michael, Beins, Eva C., Bigdeli, Tim B., Pedersen, Carsten Bøcker, Boks, Marco P., Børte, Sigrid, Bosch, Rosa, Brum, Murielle, Brumpton, Ben M., Brunkhorst-Kanaan, Nathalie, Budde, Monika, Bybjerg-Grauholm, Jonas, Byerley, William, Cabana-Domínguez, Judit, Cairns, Murray J., Carpiniello, Bernardo, Casas, Miquel, Cervantes, Pablo, Chatzinakos, Chris, Chen, Hsi-Chung, Clarence, Tereza, Clarke, Toni-Kim, Claus, Isabelle, Coombes, Brandon, Corfield, Elizabeth C., Cruceanu, Cristiana, Cuellar-Barboza, Alfredo, Czerski, Piotr M., Dafnas, Konstantinos, Dale, Anders M., Dalkner, Nina, Degenhardt, Franziska, DePaulo, J. Raymond, Djurovic, Srdjan, Drange, Ole Kristian, Escott-Price, Valentina, Fanous, Ayman H., Fellendorf, Frederike T., Ferrier, I. Nicol, Forty, Liz, Frank, Josef, Frei, Oleksandr, Freimer, Nelson B., Fullard, John F., Garnham, Julie, Gizer, Ian R., Gordon, Scott D., Gordon-Smith, Katherine, Greenwood, Tiffany A., Grove, Jakob, Guzman-Parra, José, Ha, Tae Hyon, Hahn, Tim, Haraldsson, Magnus, Hautzinger, Martin, Havdahl, Alexandra, Heilbronner, Urs, Hellgren, Dennis, Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Holmans, Peter A., Huang, Ming-Chyi, Ikeda, Masashi, Jamain, Stéphane, Johnson, Jessica S., Jonsson, Lina, Kalman, Janos L., Kamatani, Yoichiro, Kennedy, James L., Kim, Euitae, Kim, Jaeyoung, Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Kranz, Thorsten M., Krebs, Kristi, Kushner, Steven A., Lavebratt, Catharina, Lawrence, Jacob, Leber, Markus, Lee, Heon-Jeong, Liao, Calwing, Lucae, Susanne, Lundberg, Martin, MacIntyre, Donald J., Maier, Wolfgang, Maihofer, Adam X., Malaspina, Dolores, Manchia, Mirko, Maratou, Eirini, Martinsson, Lina, Mattheisen, Manuel, McGregor, Nathaniel W., McInnis, Melvin G., McKay, James D., Medeiros, Helena, Meyer-Lindenberg, Andreas, Millischer, Vincent, Morris, Derek W., Moutsatsou, Paraskevi, Mühleisen, Thomas W., O’Donovan, Claire, Olsen, Catherine M., Panagiotaropoulou, Georgia, Papiol, Sergi, Pardiñas, Antonio F., Park, Hye Youn, Perry, Amy, Pfennig, Andrea, Pisanu, Claudia, Potash, James B., Quested, Digby, Rapaport, Mark H., Regeer, Eline J., Rice, John P., Rivera, Margarita, Schulte, Eva C., Senner, Fanny, Shadrin, Alexey, Shilling, Paul D., Sigurdsson, Engilbert, Sindermann, Lisa, Sirignano, Lea, Siskind, Dan, Slaney, Claire, Sloofman, Laura G., Smeland, Olav B., Smith, Daniel J., Sobell, Janet L., Soler Artigas, Maria, Stein, Dan J., Stein, Frederike, Su, Mei-Hsin, Sung, Heejong, Świątkowska, Beata, Terao, Chikashi, Tesfaye, Markos, Tesli, Martin, Thorgeirsson, Thorgeir E., Thorp, Jackson G., Toma, Claudio, Tondo, Leonardo, Tooney, Paul A., Tsai, Shih-Jen, Tsermpini, Evangelia Eirini, Vawter, Marquis P., Vedder, Helmut, Vreeker, Annabel, Walters, James T. R., Winsvold, Bendik S., Witt, Stephanie H., Won, Hong-Hee, Ye, Robert, Young, Allan H., Zandi, Peter P., Zillich, Lea, Adolfsson, Rolf, Alda, Martin, Alfredsson, Lars, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Bengesser, Susanne, Berrettini, Wade H., Biernacka, Joanna M., Boehnke, Michael, Børglum, Anders D., Breen, Gerome, Carr, Vaughan J., Catts, Stanley, Cichon, Sven, Corvin, Aiden, Craddock, Nicholas, Dannlowski, Udo, Dikeos, Dimitris, Etain, Bruno, Ferentinos, Panagiotis, Frye, Mark, Fullerton, Janice M., Gawlik, Micha, Gershon, Elliot S., Goes, Fernando S., Green, Melissa J., Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Henskens, Frans A., Hjerling-Leffler, Jens, Hougaard, David M., Hveem, Kristian, Iwata, Nakao, Jones, Ian, Jones, Lisa A., Kahn, René S., Kelsoe, John R., Kircher, Tilo, Kirov, George, Kuo, Po-Hsiu, Landén, Mikael, Leboyer, Marion, Li, Qingqin S., Lissowska, Jolanta, Lochner, Christine, Loughland, Carmel, Luykx, Jurjen J., Martin, Nicholas G., Mathews, Carol A., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Medland, Sarah E., Melle, Ingrid, Milani, Lili, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Myung, Woojae, Neale, Benjamin M., Nievergelt, Caroline M., Nordentoft, Merete, Nöthen, Markus M., Nurnberger, John I., O’Donovan, Michael C., Oedegaard, Ketil J., Olsson, Tomas, Owen, Michael J., Paciga, Sara A., Pantelis, Christos, Pato, Carlos N., Pato, Michele T., Patrinos, George P., Pawlak, Joanna M., Ramos-Quiroga, Josep Antoni, Reif, Andreas, Reininghaus, Eva Z., Ribasés, Marta, Rietschel, Marcella, Ripke, Stephan, Rouleau, Guy A., Roussos, Panos, Saito, Takeo, Schall, Ulrich, Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Scott, Laura J., Scott, Rodney J., Serretti, Alessandro, Smoller, Jordan W., Squassina, Alessio, Stahl, Eli A., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Streit, Fabian, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne E., Vieta, Eduard, Vincent, John B., Waldman, Irwin D., Weickert, Cynthia S., Weickert, Thomas W., Werge, Thomas, Whiteman, David C., Zwart, John-Anker, Edenberg, Howard J., McQuillin, Andrew, Forstner, Andreas J., Mullins, Niamh, Di Florio, Arianna, Ophoff, Roel A., and Andreassen, Ole A.
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- 2025
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49. Microglia as hunters or gatherers of brain synapses
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Pereira-Iglesias, Marta, Maldonado-Teixido, Joel, Melero, Alejandro, Piriz, Joaquin, Galea, Elena, Ransohoff, Richard M., and Sierra, Amanda
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- 2025
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50. Structural controls on cobalt mineralisation during regional metamorphism: an example from the Rajapalot area, Finland
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Sayab, Mohammad, Menzies, Andrew, Palin, Richard M., Butcher, Alan R., Cook, Nick, Kuva, Jukka, and Dehaine, Quentin
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- 2025
- Full Text
- View/download PDF
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