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1. Supplementary Methods from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients

Author

Patrick Hwu, Audrey Gonzalez, Seth Wardell, Renjith Ramachandran, Christopher Toth, Orenthial J. Fulbright, Rahmatu Mansaray, Michael A. Davies, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Sapna Patel, Wen-Jen Hwu, Agop Bedikian, Jade Homsi, Kevin Kim, Nicholas Papadopoulos, Victor Prieto, Elizabeth Shpall, John D. McMannis, Valen E. Johnson, Michelle Glass, Gladys Alvarado, Sandy Mahoney, Gregory Lizee, Richard Wu, Jessica Chacon, Priscilla Miller, Patricia S. Fox, Minying Zhang, Chantale Bernatchez, and Laszlo G. Radvanyi

Abstract

PDF file - 115K

Published
2023
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2. Data from Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome

Author

Chantale Bernatchez, Rodabe N. Amaria, Patrick Hwu, Rameen Beroukhim, Carlos A. Torres-Cabala, Laszlo G. Radvanyi, Jennifer A. Wargo, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Suzanne Cain, Michael K. Wong, Hussein Tawbi, Isabella C. Glitza, Adi Diab, Michael A. Davies, Sapna P. Patel, Wen-Jen Hwu, Portia G. Velasquez, Chantell M. Farinas, Carol Vaughn, Destiny Joy Carpio, Vruti Patel, Rahmatu Mansaray, Seth Wardell, Christopher L. Toth, Audrey M. Gonzalez, Renjith Ramachandran, René J. Tavera, Shawne T. Thorsen, Esteban Flores, Arely Wahl, Ankit Bhatta, Donastas Sakellariou-Thompson, Young Uk Kim, Scott E. Woodman, Jason Roszik, Orenthial J. Fulbright, Tatiana Karpinets, Caitlin Creasy, Yuzhong Jeff Meng, Kenneth R. Hess, Cara Haymaker, and Marie-Andrée Forget

Abstract

Purpose: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has consistently demonstrated clinical efficacy in metastatic melanoma. Recent widespread use of checkpoint blockade has shifted the treatment landscape, raising questions regarding impact of these therapies on response to TIL and appropriate immunotherapy sequence.Patients and Methods: Seventy-four metastatic melanoma patients were treated with autologous TIL and evaluated for clinical response according to irRC, overall survival, and progression-free survival. Immunologic factors associated with response were also evaluated.Results: Best overall response for the entire cohort was 42%; 47% in 43 checkpoint-naïve patients, 38% when patients were exposed to anti-CTLA4 alone (21 patients) and 33% if also exposed to anti-PD1 (9 patients) prior to TIL ACT. Median overall survival was 17.3 months; 24.6 months in CTLA4-naïve patients and 8.6 months in patients with prior CTLA4 blockade. The latter patients were infused with fewer TIL and experienced a shorter duration of response. Infusion of higher numbers of TIL with CD8 predominance and expression of BTLA correlated with improved response in anti-CTLA4 naïve patients, but not in anti-CTLA4 refractory patients. Baseline serum levels of IL9 predicted response to TIL ACT, while TIL persistence, tumor recognition, and mutation burden did not correlate with outcome.Conclusions: This study demonstrates the deleterious effects of prior exposure to anti-CTLA4 on TIL ACT response and shows that baseline IL9 levels can potentially serve as a predictive tool to select the appropriate sequence of immunotherapies. Clin Cancer Res; 24(18); 4416–28. ©2018 AACR.

Published
2023
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3. Supplementary Table 5 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients

Author

Patrick Hwu, Audrey Gonzalez, Seth Wardell, Renjith Ramachandran, Christopher Toth, Orenthial J. Fulbright, Rahmatu Mansaray, Michael A. Davies, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Sapna Patel, Wen-Jen Hwu, Agop Bedikian, Jade Homsi, Kevin Kim, Nicholas Papadopoulos, Victor Prieto, Elizabeth Shpall, John D. McMannis, Valen E. Johnson, Michelle Glass, Gladys Alvarado, Sandy Mahoney, Gregory Lizee, Richard Wu, Jessica Chacon, Priscilla Miller, Patricia S. Fox, Minying Zhang, Chantale Bernatchez, and Laszlo G. Radvanyi

Abstract

PDF file - 77K, Long term changes in the persistence of TCR Vβ clonotypes in the blood following TIL adoptive transfer in representative responding patients

Published
2023
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4. Supplementary Table 1 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients

Author

Patrick Hwu, Audrey Gonzalez, Seth Wardell, Renjith Ramachandran, Christopher Toth, Orenthial J. Fulbright, Rahmatu Mansaray, Michael A. Davies, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Sapna Patel, Wen-Jen Hwu, Agop Bedikian, Jade Homsi, Kevin Kim, Nicholas Papadopoulos, Victor Prieto, Elizabeth Shpall, John D. McMannis, Valen E. Johnson, Michelle Glass, Gladys Alvarado, Sandy Mahoney, Gregory Lizee, Richard Wu, Jessica Chacon, Priscilla Miller, Patricia S. Fox, Minying Zhang, Chantale Bernatchez, and Laszlo G. Radvanyi

Abstract

PDF file - 58K, Demographics and clinical characteristics of enrolled patients

Published
2023
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5. Supplementary Figures 1 - 7 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients

Author

Patrick Hwu, Audrey Gonzalez, Seth Wardell, Renjith Ramachandran, Christopher Toth, Orenthial J. Fulbright, Rahmatu Mansaray, Michael A. Davies, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Sapna Patel, Wen-Jen Hwu, Agop Bedikian, Jade Homsi, Kevin Kim, Nicholas Papadopoulos, Victor Prieto, Elizabeth Shpall, John D. McMannis, Valen E. Johnson, Michelle Glass, Gladys Alvarado, Sandy Mahoney, Gregory Lizee, Richard Wu, Jessica Chacon, Priscilla Miller, Patricia S. Fox, Minying Zhang, Chantale Bernatchez, and Laszlo G. Radvanyi

Abstract

PDF file - 1856K, Fig. S1. Schema of TIL adoptive cell therapy clinical trial; Fig. S2. Recovery of total white blood cell counts (WBC), absolute lymphocyte counts (ALC), and absolute neutrophil counts (ANC) during adoptive transfer TIL therapy in 31 treated patients; Fig. S3. Durable partial response of an intrathoracic melanoma mass near the aorta and heart in one patient at 6 weeks and 18 months after TIL infusion; Figure S4. Kaplan-Meier curves of overall survival and progression-free survival for all 31 treated patients; Figure S5. Kaplan-Meier curves of landmark-based overall survival and progression-free survival for irRC responding and non-responding TIL-treated patients; Fig. S6. Change in tumor burden over the first 20-22 months following TIL transfer therapy in responders and non-responders; Fig. S7. Box and whisker plot showing that telomere length of infused TIL was not significantly different between responders and non-responders

Published
2023
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6. Supplementary Figure and Supplementary Tables from Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome

Author

Chantale Bernatchez, Rodabe N. Amaria, Patrick Hwu, Rameen Beroukhim, Carlos A. Torres-Cabala, Laszlo G. Radvanyi, Jennifer A. Wargo, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Suzanne Cain, Michael K. Wong, Hussein Tawbi, Isabella C. Glitza, Adi Diab, Michael A. Davies, Sapna P. Patel, Wen-Jen Hwu, Portia G. Velasquez, Chantell M. Farinas, Carol Vaughn, Destiny Joy Carpio, Vruti Patel, Rahmatu Mansaray, Seth Wardell, Christopher L. Toth, Audrey M. Gonzalez, Renjith Ramachandran, René J. Tavera, Shawne T. Thorsen, Esteban Flores, Arely Wahl, Ankit Bhatta, Donastas Sakellariou-Thompson, Young Uk Kim, Scott E. Woodman, Jason Roszik, Orenthial J. Fulbright, Tatiana Karpinets, Caitlin Creasy, Yuzhong Jeff Meng, Kenneth R. Hess, Cara Haymaker, and Marie-Andrée Forget

Abstract

Supplementary figures and tables

Published
2023
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7. Supplementary Table 2 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients

Author

Patrick Hwu, Audrey Gonzalez, Seth Wardell, Renjith Ramachandran, Christopher Toth, Orenthial J. Fulbright, Rahmatu Mansaray, Michael A. Davies, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Sapna Patel, Wen-Jen Hwu, Agop Bedikian, Jade Homsi, Kevin Kim, Nicholas Papadopoulos, Victor Prieto, Elizabeth Shpall, John D. McMannis, Valen E. Johnson, Michelle Glass, Gladys Alvarado, Sandy Mahoney, Gregory Lizee, Richard Wu, Jessica Chacon, Priscilla Miller, Patricia S. Fox, Minying Zhang, Chantale Bernatchez, and Laszlo G. Radvanyi

Abstract

PDF file - 69K, Derivation of the irRC best overall score

Published
2023
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8. Supplementary Table 3 - 4 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients

Author

Patrick Hwu, Audrey Gonzalez, Seth Wardell, Renjith Ramachandran, Christopher Toth, Orenthial J. Fulbright, Rahmatu Mansaray, Michael A. Davies, Janice N. Cormier, Richard Royal, Anthony Lucci, Jeffrey E. Gershenwald, Jeffrey E. Lee, Merrick I. Ross, Sapna Patel, Wen-Jen Hwu, Agop Bedikian, Jade Homsi, Kevin Kim, Nicholas Papadopoulos, Victor Prieto, Elizabeth Shpall, John D. McMannis, Valen E. Johnson, Michelle Glass, Gladys Alvarado, Sandy Mahoney, Gregory Lizee, Richard Wu, Jessica Chacon, Priscilla Miller, Patricia S. Fox, Minying Zhang, Chantale Bernatchez, and Laszlo G. Radvanyi

Abstract

PDF file - 76k, Table S3. Associations between categorical patient variables and clinical response; Table S4. Associations between continuous variables and clinical response

Published
2023
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10. Racial disparities in preoperative chemotherapy use in gastric cancer patients in the United States: Analysis of the National Cancer Data Base, 2006-2014

Author

Naruhiko, Ikoma, Janice N, Cormier, Barry, Feig, Xianglin L, Du, Jose-Miguel, Yamal, Wayne, Hofstetter, Prajnan, Das, Jaffer A, Ajani, Christina L, Roland, Keith, Fournier, Richard, Royal, Paul, Mansfield, and Brian D, Badgwell

Subjects
Adult, Male, Adenocarcinoma, Middle Aged, Insurance Coverage, United States, Article, Logistic Models, Stomach Neoplasms, Preoperative Period, Humans, Female, Healthcare Disparities, Aged, Quality of Health Care, Retrospective Studies
Abstract

No studies have investigated whether race/ethnicity is associated with the recommended use of preoperative chemotherapy or subsequent outcomes in gastric cancer. To determine whether there is such an association, analyses of patients with gastric cancer in the National Cancer Data Base (NCDB) were performed.Patients with clinical T2-4bN0-1M0 gastric adenocarcinoma, as defined by the eighth edition of the American Joint Committee on Cancer staging manual, who underwent gastrectomy from 2006 to 2014 were identified from the NCDB. Multiple logistic regression was conducted to examine factors associated with preoperative chemotherapy use.This study identified 16,945 patients who met the criteria, and 8286 of these patients (49%) underwent preoperative chemotherapy. The use of preoperative chemotherapy remarkably increased over the study period, from 34% in 2006 to 65% in 2014. Preoperative chemotherapy was more commonly used for cardia tumors than noncardia tumors (83% vs 44% in 2014). In a multivariable analysis, races and ethnicities other than non-Hispanic (NH) white race were associated with less frequent use of preoperative chemotherapy in comparison with NH whites after adjustments for social, tumor, and hospital factors. The insurance status and the education level mediated an enhanced effect of racial/ethnic disparities in preoperative chemotherapy use. The use of preoperative chemotherapy and radiation therapy was associated with reduced racial/ethnic disparities in overall survival.Racial/ethnic disparities in the use of preoperative chemotherapy and in outcomes exist among patients with gastric cancer in the United States. Efforts to improve the access to high-quality cancer care in minority groups may reduce racial disparities in gastric cancer in the United States. Cancer 2018;124:998-1007. © 2018 American Cancer Society.

Published
2017

11. Early Recollections in Life Style Assessment and Counseling

Author

Kopp, Richard Royal and Dinkmeyer, Don

Abstract

Describes the interpretation of early recollections of clients as a technique for life style assessment. The client's recollections are posited as reflecting the way he/she sees himself/herself in relation to the world and others. Idiographic assessment presents a picture of the basic beliefs and motives of the student. (SJL)

Published
1975

12. Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

Author

Rodabe N. Amaria, Sangeetha M. Reddy, Hussein A. Tawbi, Michael A. Davies, Merrick I. Ross, Isabella C. Glitza, Janice N. Cormier, Carol Lewis, Wen-Jen Hwu, Ehab Hanna, Adi Diab, Michael K. Wong, Richard Royal, Neil Gross, Randal Weber, Stephen Y. Lai, Richard Ehlers, Jorge Blando, Denái R. Milton, Scott Woodman, Robin Kageyama, Daniel K. Wells, Patrick Hwu, Sapna P. Patel, Anthony Lucci, Amy Hessel, Jeffrey E. Lee, Jeffrey Gershenwald, Lauren Simpson, Elizabeth M. Burton, Liberty Posada, Lauren Haydu, Linghua Wang, Shaojun Zhang, Alexander J. Lazar, Courtney W. Hudgens, Vancheswaran Gopalakrishnan, Alexandre Reuben, Miles C. Andrews, Christine N. Spencer, Victor Prieto, Padmanee Sharma, James Allison, Michael T. Tetzlaff, and Jennifer A. Wargo

Subjects
General Medicine, General Biochemistry, Genetics and Molecular Biology
Published
2018
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13. Measurement and Modeling of Anisotropic Spatial Variability of Soils for Probabilistic Stability Analysis of Earth Slopes

Author

Alfaro, Marolo (Civil Engineering) Rasmussen, Peter (Civil Engineering) Alfa, Attahiru (Electrical and Computer Engineering) Bathurst, Richard (Royal Military College of Canada), Blatz, James (Civil Engineering), Van Helden, Michael John, Alfaro, Marolo (Civil Engineering) Rasmussen, Peter (Civil Engineering) Alfa, Attahiru (Electrical and Computer Engineering) Bathurst, Richard (Royal Military College of Canada), Blatz, James (Civil Engineering), and Van Helden, Michael John

Abstract

Geotechnical engineering design has relied upon deterministic methods of analysis whereby values for analysis parameters and conditions are selected subjectively based on judgment with the intent of providing acceptable margins of safety. The objective of this research was to improve the use of probabilistic slope stability analysis in practice so that the design of slopes can be made on a consistent and probabilistic basis. The current research involved the development of a methodology for the measurement and modeling of the anisotropic autocorrelation distance of cohesive soils, which was demonstrated at Dyke 17 West of the McArthur Falls Generating Station. In-situ testing using the piezocone and laboratory testing was conducted to characterize the spatial variability of the effective-shear strength envelope. Vertical (down-hole) and horizontal (cross-hole) geostatistical analysis was conducted to assess the anisotropy of the semivariogram. The investigation identified that heterogeneous inclusions had significant impacts on the results, but that simplistic (visual) identification and filtering procedures were adequate. The effective-stress shear strength envelope was statistically characterized as a random field, which was simulated as a first-order Markov process using customized add-in functions in a limit-equilibrium slope stability analysis. The analysis accounts for the spatial variability of shear strength and is capable of simulating both isotropic and anisotropic autocorrelation functions. The study showed that the critical slip surface geometry and the probability of failure can be significantly different when the anisotropy of spatial correlation is accounted for. The study also showed that neglecting spatial correlation may over-estimate the probability of failure, however this finding was noted to be likely case-specific. The primary conclusion of the study was that appropriate representation of spatial correlation is essential to calculating the pro

Published
2013

16. Life Style and the Roles of the Supervisor in an Organization: An Integration.

Author

Schoenwald, Ira S. and Kopp, Richard Royal

Subjects
*LIFESTYLES, *EXECUTIVES, *ADLERIAN psychology
Abstract

Discusses the influence of life style on the role of executives in an organization. Concept of role making; Link between individual psychology and organizational behavior; Applications of life-style to management.

Published
1986

17. Styles of Striving for Significance with and without Social Interest: An Adlerian Typology.

Author

Kopp, Richard Royal

Subjects
*LIFESTYLES, *ADLERIAN psychology
Abstract

Focuses on the Adlerian theory of the styles of striving for significance with social interest. Definition of life styles; Literature review on the techniques of striving for significance without social interest; Difference between role characterization and life style.

Published
1986

22. A HOLISTIC APPROACH TO MIND AND NATURE.

Author

Kopp, Richard Royal

Subjects
*ADLERIAN psychology, *NONFICTION
Abstract

Reviews the book 'Mind and Nature: A Necessary Unit,' by Gregory Bateson.

Published
1980

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