32 results on '"Richard Howe"'
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2. Level 1/Level 2 Cambridge National in IT (J836): Second Edition
- Author
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Maureen Everett, Sonia Stuart, Richard Howe, Maureen Everett, Sonia Stuart, and Richard Howe
- Subjects
- Electronic data processing, Information technology
- Abstract
Trust highly experienced teachers and authors Mo Everett, Richard Howe and Sonia Stuart to guide learners through the redeveloped Level 1/ Level 2 Cambridge National in IT (J836). This thorough and accessible introduction to the IT industry will develop your learners'understanding of the core examined content and boost the skills required to tackle the NEA with confidence. This revised and updated textbook is:- Comprehensive. Gain in-depth knowledge of the examined unit with clear explanations of every concept and topic, and develop the skills and understanding for the practical non-examined units, both of which are covered in detail.- Accessible, reliable and trusted. Structured to match the specification and provide the information required to build knowledge, understanding and skills across accessible and easy-to-use chapters and learning features.- Designed to support you. Boost confidence when preparing for assessment with plenty of activities and practice questions.- Your go-to guide. Expert authors have carefully designed tasks and activities to build your skills and aid progression, and written questions to assess your understanding.
- Published
- 2022
3. Translator’s Note
- Author
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Richard Howe
- Published
- 2018
4. ‘Famous Throughout the Whole World of Music’, 1640–1701
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Richard Howe and Michael Maul
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Attractiveness ,Matriculation ,History ,media_common.quotation_subject ,Opera ,Town council ,language.human_language ,German ,Excellence ,language ,Boarding school ,Classics ,Period (music) ,media_common - Abstract
Boarding school statistics and personnel after 1634 The second half of the seventeenth century was the period in which the St. Thomas School most resolutely pursued its mission to be a ‘music school’ as set forth in the school regulations of 1634, and as a result came to be a byword for excellence as a top-notch producer of trained musicians. In these years the number of Thomaners who went on to become professional musicians was legion. The most prominent graduates were the later St. Thomas School cantor Johann Schelle (enrolled at the school in 1665); the ‘inventor’ of German opera, Reinhard Keiser (enrolled 1685; appointed prefect of the First Cantorey 1692; plate 22); the Darmstadt court capellmeister Christoph Graupner (enrolled 1695), the Dresden court capellmeister Johann David Heinichen (enrolled 1696), and the Merseburg court capellmeister Johann Theodor Romhildt (enrolled 1697). At no other time did the St. Thomas School produce so many first-rate musicians. With the school's growing fame, the attractiveness of a place at the boarding school also increased. Almost every week musically trained boys from Saxony, but also from Thuringia and even more distant locales, arrived at the school to audition in the hope of getting on the waiting list that offered such promising career prospects. Countless entries in Rector Thomasius's journal attest to this lively coming and going in the late 1670s and early 1680s. The boys who were admitted were on average fourteen years old (so their voices had not yet changed – the average age for the onset of puberty in the seventeenth century may have been as late as sixteen or even seventeen) and were pledged to an average stay of five to six years (with the option to stay longer, plate 21). But above all it is the St. Thomas School matriculation book, which has survived complete and intact from 1640 onward, that shows that the town council did not (at first) resume the practice of requiring the school's leadership to admit great numbers of impoverished Leipzig boys, who were proverbially unmusical (p. 98). Despite the hardships of the Thirty Years War, the documented share of the town's children at the boarding school in the years 1640–1657 of Tobias Michael's cantorate (1631–1657) was about 9.6 percent (18 out 187 boys altogether).
- Published
- 2018
5. ‘Odd Authorities with Little Interest in Music’: the St. Thomas School in Crisis, 1701–1730
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Michael Maul and Richard Howe
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History ,Regent ,media_common.quotation_subject ,Wife ,Fall of man ,Deliberation ,Classics ,Order (virtue) ,media_common - Abstract
Bach's letter to Erdmann In the fall of 1730, the forty-five-year-old St. Thomas school cantor, Johann Sebastian Bach, took up his pen in order to write a letter to his old schoolmate, Georg Erdmann, with whom he had attended school in Ohrdruf. In 1700, the two had travelled together to Luneburg, where they had both enrolled in the St. Michaelis school. Erdmann had gone on to study law, and in 1718 had become Russia's diplomatic representative in Danzig. In 1726, after a long pause, Erdmann attempted to resume contact with Bach, asking for news of his Fatalitaten, i.e., the main events of his life over the last two decades. But the St. Thomas cantor let their correspondence fall by the wayside again after just one short letter – probably on account of ‘his many activities’ that scarcely left time enough even for ‘the most necessary correspondence’ – and in 1730, Bach still owed Erdmann the news he had been asked for in 1726. Now, on October 28, 1730, Bach informed Erdmann that his familial situation was satisfactory. By now he had seven children from two marriages (four sons and three daughters); all of them were ‘born musicians’, with whom he could present vocal and instrumental concerts, especially because his second wife, Anna Magdalena, ‘sings a good, clear soprano’ and his eldest daughter ‘joins in not badly’. The picture Bach drew of his professional situation was, however, completely different. His former master, Prince Leopold von Anhalt-Cothen, was a prince ‘who both loved and knew music’, for which reason Bach had believed he could live out the rest of his life in Cothen. But as fate would have it, in December 1721, the regent married a totally unmusical princess from Bernburg (his second marriage), as a result of which the prince's future ‘inclination’ to music was already in danger. And because the Leipzig cantorate had been described to Bach as ‘so favorable’, and the town had in any event offered much better educational opportunities for his sons than Cothen, in the end he had moved to Leipzig, but only after much deliberation, because ‘it did not seem at all proper to me to exchange my post as capellmeister for that of a cantor’.
- Published
- 2018
6. How the St. Thomas School Became a Music School, 1594–1640
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Richard Howe and Michael Maul
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History ,State (polity) ,media_common.quotation_subject ,Sacred music ,Prosperity ,Musical ,Singing ,Leipzig school ,Order (virtue) ,media_common ,Visual arts - Abstract
Singing for endowments and the growth of the school: a causal relationship To understand why around the turn of the seventeenth century the St. Thomas School was transformed into a music school that became famous far beyond Leipzig, we must look at a passage in the new Leipzig school regulations of 1634, the first ever to be printed. The beginning of chapter VII says that a boy desiring admission to the St. Thomas School as a boarder would have to demonstrate above-average vocal and musical abilities. The passage goes on to refer to an important relationship: That the school's progress and prosperity in previous years were manifestly furthered because the boys who were selected and admitted had a greater aptitude for music than those at the St. Nicholas school and performed in both churches, at funerals and weddings, and, finally, in the rounds of street singing, is beyond any doubt. For many people, sacred music, when sung in the churches and elsewhere, gives rise to an especially intense state of devotion, which is not the least of the reasons why in former times various legacies stipulated the better provisioning of the boys in the said school, and also some people, while still living, generously made weekly or monthly donations to be used for that purpose. For that reason, it is only proper to ensure, when auditioning and admitting boys who are over twelve years of age and desire to board at the school, that they are not untutored in the art of music but are sufficiently experienced, and can perform a piece of music in an accomplished and appropriately artful manner. In other words, the Thomaners’ singing in the churches, at special occasions, and in the streets had made the school rich from performance fees and donations by the Leipzig townspeople, and in order to continue this success story, it became an iron-clad rule that the St. Thomas boarders all had to be musical. This passage in the 1634 school regulations would have read very differently had it been written three years previously.
- Published
- 2018
7. School for Scholars or ‘Conservatory of Music’? An ongoing conflict, 1730–1804
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Richard Howe and Michael Maul
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media_common.quotation_subject ,Unanimity ,Political science ,Foreign language ,Town hall ,Town council ,Praise ,Plenary session ,Classics ,media_common ,Lexicography - Abstract
Good times for cantors: Johann Matthias Gesner's rectorate (1730–1734) On June 6, 1730, the elders’ council met at the town hall to deal with the vacancy in the St. Thomas rectorate. Applications and recommendations had been received in great numbers. The last of these candidates, presented by Mayor Born, was the rector of the Ansbach Gymnasium, Johann Matthias Gesner (plate 51). In Born's eyes, Gesner was most qualified candidate – above all because the highestranking princely-electoral education official in Saxony, the president of the superior consistory, Heinrich Count von Bunau, would ‘praise him highly’. Gesner had been ‘informed of the conditions at the school here’ and he had promised to accept the office ‘if he were called to it legitimately’. Of course, if the Ansbach rector were to be hired, it would still be necessary to ‘ensure’ that he would accept ‘no profession’, i.e., no parallel office at the university. Christian Gottlieb Jocher, who would later be famous as a lexicographer, was also still being considered as a more or less equally qualified candidate. The first of the mayors to vote, Mayor Lange, rejected Mayor Born's candidate. He spoke emphatically in favor of Jocher or the conrector of the St. Thomas School, Hebenstreit, who was lauded on all sides, but had been declared unelectable on account of his deficient authority. The third mayor, however, Adrian Steger, jumped in to support Mayor Born. Since Hebenstreit ‘had not won the school's respect’, Steger preferred Gesner ‘most of all’, especially since the president of the superior consistory had already ‘written to Ansbach on his behalf’. In the end, all the other town council members voted for Gesner, a unanimity of opinion that also dominated the plenary session of the three councils two days later. Once again Born referred to Count von Bunau, who had praised Gesner's knowledge of foreign languages. In addition, he stressed that the agreement with the new rector regarding his not accepting a professorship at the university had to be written in such a way that Gesner would have to give up his position at the school immediately in the event of his accepting a call from the university.
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- 2018
8. Bach's Famous Choir
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Michael Maul and Richard Howe
- Published
- 2018
9. Cambridge Technicals Level 3 Digital Media
- Author
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Victoria Allen, Karl Davis, Richard Howe, Ian Marshall, Kevin Wells, Victoria Allen, Karl Davis, Richard Howe, Ian Marshall, and Kevin Wells
- Subjects
- Digital media--Textbooks
- Abstract
Exam Board: CambridgeLevel: KS4Subject: Digital MediaFirst Teaching: September 2016First Exam: June 2018Support your teaching of the new Cambridge Technicals 2016 suite with Cambridge Technical Level 3 Digital Media, developed in partnership between OCR and Hodder Education; this textbook covers each specialist pathway and ensures your ability to deliver a flexible course that is both vocationally focused and academically thorough.Cambridge Technical Level 3 Digital Media is matched exactly to the new specification and follows specialist pathways in digital content for interactive media, and moving image and audio production.- Ensures effective teaching of each specialist pathway offered within the qualification.- Focuses learning on the skills, knowledge and understanding demanded from employers and universities.- Provides ideas and exercises for the application of practical skills and knowledge.- Developed in partnership between Hodder Education and OCR, guaranteeing quality resources which match the specification perfectlyHodder Education have worked with OCR to make updates to our Cambridge Technicals textbooks to bring them more closely in line with the model assignment course requirements. We would like to let you know about a recent change to this textbook, updated pages which are now available free of charge as a PDF when you click on the'Amended Pages'link on the left of this webpage.
- Published
- 2016
10. New high-resolution geodynamic and landscape evolution models for Africa from the Permian to the present day
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Henry Wareham, Tom Wiggins, Abigail Redmile, Laura Duthie, Peter Phillips, Dorothea Eue, David Sagi, Richard Howe, Laura Hagan, James Martin, Amanda Galsworthy, and Kate Benny
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Paleontology ,Permian ,Earth science ,High resolution ,Present day ,Geology - Published
- 2016
11. Forest education and research in the United Kingdom
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Richard Howe, Peter Freer‐Smith, Kristina Plenderleith, and Jeffery Burley
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Environmental studies ,Government ,Development studies ,Wood production ,Sustainability ,Forestry ,Minor (academic) ,Woodland ,Cubic metre ,Management, Monitoring, Policy and Law ,Agricultural economics - Abstract
The total area of woodland in Great Britain (GB) is 2.7 m hectares of which one‐third is State‐owned and two‐thirds private; total annual wood production approximates 12 m cubic meters, while total imports of forest products approximate 48 m cubic meters. Public and government interest in forests and woodlands is significant and growing. However, support for four long‐established forestry educational institutions is diminishing accompanied by a decline in the number of applicants for university and college places in forestry courses (325 in 1996 to 156 in 2003). At the same time, there is an increase in the number of institutions (44 in 2004) offering forestry‐related subjects at postgraduate, undergraduate and technical levels although many of these are minor components within wider courses of anthropology, biology, conservation, development studies, environmental studies, geography and zoology. While these are laudable, there is concern within the forestry profession at the potential decline in educatio...
- Published
- 2005
12. Abstracts from The Cold Weather Operations Conference 2021
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Arne Johan Norheim, Bård Rannestad, Richard Howes, Erling Bekkestad Rein, Ellen Jørum, Karl Friedl, George Havenith, Hilde Kristin Teien, James Brian Mercer, Jørgen Melau, Louis de Weerd, Michael Smith, Natalie Taylor, Øyvind Albert Voie, Pål Bergan-Skar, Steve Andrews, Torvind Næsheim, and Tuva Steinberg
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Cold weather injury ,freezing cold injury ,hypothermia ,military ,snow avalanche ,non-freezing cold injury ,Arctic medicine. Tropical medicine ,RC955-962 - Abstract
A common effort for both military and civil healthcare is to achieve knowledge-based health care in cold weather injuries and fatal accidents in harsh arctic environment. The Cold Weather Operations Conference in November 2021, having more than 300 participants from 20 countries, was addressing the prevention and treatment of injuries and trauma care in cold weather conditions and the challenges for military prehospital casualty care. The intention of the programme was to stimulate further research and systematic knowledge-based clinical work. The abstracts from the conference present cold weather research and clinical experience relevant for readers of the International Journal of Circumpolar Health.
- Published
- 2022
- Full Text
- View/download PDF
13. Field study of the annoyance of low-frequency runway sideline noise
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Sanford Fidell, Laura Silvati, Stephen J. Lind, Richard Howe, and Karl S. Pearsons
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geography ,geography.geographical_feature_category ,Acoustics and Ultrasonics ,Noise pollution ,Acoustics ,Ambient noise level ,Annoyance ,Octave (electronics) ,Residential area ,Noise ,Arts and Humanities (miscellaneous) ,Environmental science ,Runway ,Noise barrier - Abstract
Noise from aircraft ground operations often reaches residences in the vicinity of airports via grazing incidence paths that attenuate high-frequency noise more than air-to-ground propagation paths, thus increasing the relative low-frequency content of such noise with respect to overflight noise. Outdoor A-weighted noise measurements may not appropriately reflect low-frequency noise levels that can induce potentially annoying secondary emissions inside residences near runways. Contours of low-frequency noise levels were estimated in a residential area adjacent to a busy runway from multi-site measurements of composite maximum spectra of runway sideline noise in the one-third octave bands between 25 and 80 Hz, inclusive. Neighborhood residents were interviewed to determine the prevalence of annoyance attributable to runway sideline noise at frequencies below 100 Hz, and of its audible manifestations inside homes. Survey respondents highly annoyed by rattle and vibration were concentrated in areas with low-frequency sound levels due to aircraft operations in excess of 75 to 80 dB.
- Published
- 1999
14. Field study of noise‐induced sleep disturbance
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David S. Barber, Richard Howe, Laura Silvati, Karl S. Pearsons, Sanford Fidell, and Barbara G. Tabachnick
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medicine.medical_specialty ,Sleep disorder ,Acoustics and Ultrasonics ,Meteorology ,Noise induced ,Noise pollution ,Audiology ,medicine.disease ,Sound exposure ,Noise ,Noise exposure ,Arts and Humanities (miscellaneous) ,medicine ,Sound sources ,Environmental science - Abstract
Behaviorally confirmed awakenings were recorded during nighttime hours for periods of approximately one month in 45 homes of 82 test participants. Measurements of awakening and of both indoor and outdoor noise exposure were made for a total of 632 subject nights near a military airfield, 783 subject nights near a civil airport, and 472 subject nights in neighborhoods with community noise exposure of nonaircraft origin. Sound exposure levels of individual noise intrusions were much more closely associated with awakenings than long‐term noise exposure levels. The slope of the relationship between awakening and sound exposure level was rather shallow, however. Although the present findings do not resemble those of laboratory studies of noise‐induced sleep interference, they are in good agreement with the results of other field studies.
- Published
- 1995
15. Individual common variants exert weak effects on the risk for autism spectrum disorderspi
- Author
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Anney, Richard Klei, Lambertus Pinto, Dalila Almeida, Joana and Bacchelli, Elena Baird, Gillian Bolshakova, Nadia and Boelte, Sven Bolton, Patrick F. Bourgeron, Thomas Brennan, Sean Brian, Jessica Casey, Jillian Conroy, Judith and Correia, Catarina Corsello, Christina Crawford, Emily L. de Jonge, Maretha Delorme, Richard Duketis, Eftichia Duque, Frederico Estes, Annette Farrar, Penny Fernandez, Bridget A. and Folstein, Susan E. Fombonne, Eric Gilbert, John and Gillberg, Christopher Glessner, Joseph T. Green, Andrew and Green, Jonathan Guter, Stephen J. Heron, Elizabeth A. Holt, Richard Howe, Jennifer L. Hughes, Gillian Hus, Vanessa and Igliozzi, Roberta Jacob, Suma Kenny, Graham P. Kim, Cecilia and Kolevzon, Alexander Kustanovich, Vlad Lajonchere, Clara M. and Lamb, Janine A. Law-Smith, Miriam Leboyer, Marion Le Couteur, Ann Leventhal, Bennett L. Liu, Xiao-Qing Lombard, Frances Lord, Catherine Lotspeich, Linda Lund, Sabata C. and Magalhaes, Tiago R. Mantoulan, Carine McDougle, Christopher J. and Melhem, Nadine M. Merikangas, Alison Minshew, Nancy J. and Mirza, Ghazala K. Munson, Jeff Noakes, Carolyn Nygren, Gudrun Papanikolaou, Katerina Pagnamenta, Alistair T. and Parrini, Barbara Paton, Tara Pickles, Andrew Posey, David J. and Poustka, Fritz Ragoussis, Jiannis Regan, Regina Roberts, Wendy Roeder, Kathryn Roge, Bernadette Rutter, Michael L. and Schlitt, Sabine Shah, Naisha Sheffield, Val C. Soorya, Latha Sousa, Ines Stoppioni, Vera Sykes, Nuala Tancredi, Raffaella Thompson, Ann P. Thomson, Susanne Tryfon, Ana and Tsiantis, John Van Engeland, Herman Vincent, John B. and Volkmar, Fred Vorstman, J. A. S. Wallace, Simon Wing, Kirsty and Wittemeyer, Kerstin Wood, Shawn Zurawiecki, Danielle and Zwaigenbaum, Lonnie Bailey, Anthony J. Battaglia, Agatino and Cantor, Rita M. Coon, Hilary Cuccaro, Michael L. Dawson, Geraldine Ennis, Sean Freitag, Christine M. Geschwind, Daniel H. Haines, Jonathan L. Klauck, Sabine M. McMahon, William M. Maestrini, Elena Miller, Judith Monaco, Anthony P. Nelson, Stanley F. Nurnberger, Jr., John I. Oliveira, Guiomar Parr, Jeremy R. Pericak-Vance, Margaret A. Piven, Joseph Schellenberg, Gerard D. Scherer, StephenW. Vicente, Astrid M. Wassink, Thomas H. Wijsman, Ellen M. Betancur, Catalina Buxbaum, Joseph D. Cook, Edwin H. Gallagher, Louise and Gill, Michael Hallmayer, Joachim Paterson, Andrew D. and Sutcliffe, James S. Szatmari, Peter Vieland, Veronica J. and Hakonarson, Hakon Devlin, Bernie
- Subjects
mental disorders - Abstract
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm 1). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
- Published
- 2012
16. Confirmation of the superior performance of the causal Graphical Analysis Using Genetics (cGAUGE) pipeline in comparison to various competing alternatives [version 1; peer review: 2 approved]
- Author
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Heather J. Cordell and Richard Howey
- Subjects
Causal inference ,Mendelian randomization ,Bayesian networks ,eng ,Medicine ,Science - Abstract
Various methods exist that utilise information from genetic predictors to help identify potential causal relationships between measured biological or clinical traits. Here we conduct computer simulations to investigate the performance of a recently proposed causal Graphical Analysis Using Genetics (cGAUGE) pipeline, used as a precursor to Mendelian randomization analysis, in comparison to our previously proposed Bayesian Network approach for addressing this problem. We use the same simulation (and analysis) code as was used by the developers of cGAUGE, adding in a comparison with the Bayesian Network approach. Overall, we find the optimal method (in terms of giving high power and low false discovery rate) is the cGAUGE pipeline followed by subsequent analysis using the MR-PRESSO Mendelian randomization approach.
- Published
- 2022
- Full Text
- View/download PDF
17. Effects on sleep disturbance of changes in aircraft noise near three airports
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Richard Howe, Karl S. Pearsons, Barbara G. Tabachnick, and Sanford Fidell
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Sleep Wake Disorders ,Sleep disorder ,Acoustics and Ultrasonics ,Aircraft noise ,Meteorology ,Aircraft ,Noise pollution ,Flight operations ,Poison control ,Environmental Exposure ,medicine.disease ,International airport ,Noise ,Arts and Humanities (miscellaneous) ,medicine ,Environmental science ,Humans ,Runway - Abstract
Field measurements were conducted of potential sleep disturbance associated with changes in nighttime aircraft noise exposure near three airports. One study was conducted near Stapleton International Airport (DEN) and Denver International Airport (DIA) in anticipation of the closure of the former and opening of the latter. Sleep behavior was monitored in 57 homes located near runway ends at the two airports. A second study was conducted in the vicinity of DeKalb-Peachtree Airport (PDK), a large general aviation airport that expected increased nighttime flight operations due to the Olympic Games in July and August of 1996. Similar methods of measuring nighttime noise levels and sleep disturbance in the two studies were maintained over the course of 2717 and 686 subject-nights of observations, respectively. No major differences in noise-induced sleep disturbance were observed as a function of changes in nighttime aircraft noise exposure.
- Published
- 2000
18. A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships.
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Richard Howey, Alexander D Clark, Najib Naamane, Louise N Reynard, Arthur G Pratt, and Heather J Cordell
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Genetics ,QH426-470 - Abstract
Bayesian networks can be used to identify possible causal relationships between variables based on their conditional dependencies and independencies, which can be particularly useful in complex biological scenarios with many measured variables. Here we propose two improvements to an existing method for Bayesian network analysis, designed to increase the power to detect potential causal relationships between variables (including potentially a mixture of both discrete and continuous variables). Our first improvement relates to the treatment of missing data. When there is missing data, the standard approach is to remove every individual with any missing data before performing analysis. This can be wasteful and undesirable when there are many individuals with missing data, perhaps with only one or a few variables missing. This motivates the use of imputation. We present a new imputation method that uses a version of nearest neighbour imputation, whereby missing data from one individual is replaced with data from another individual, their nearest neighbour. For each individual with missing data, the subsets of variables to be used to select the nearest neighbour are chosen by sampling without replacement the complete data and estimating a best fit Bayesian network. We show that this approach leads to marked improvements in the recall and precision of directed edges in the final network identified, and we illustrate the approach through application to data from a recent study investigating the causal relationship between methylation and gene expression in early inflammatory arthritis patients. We also describe a second improvement in the form of a pseudo-Bayesian approach for upweighting certain network edges, which can be useful when there is prior evidence concerning their directions.
- Published
- 2021
- Full Text
- View/download PDF
19. Field Studies of Habituation to Change in Nighttime Aircraft Noise and of Sleep Motility Measurement Methods
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Sanford Fidell, Laura Silvati, Matthew Sneddon, Richard Howe, Barbara G. Tabachnick, Karl S. Pearsons, and Elizabeth Fletcher
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Measurement method ,Sleep disorder ,medicine.medical_specialty ,Meteorology ,Aircraft noise ,Upon Awakening ,Audiology ,medicine.disease ,Sound exposure ,Geography ,Duration (music) ,medicine ,Sleep (system call) ,Habituation - Abstract
A field study of habituation to aircraft noise-induced sleep disturbance was conducted near DeKalb-Peachtree Airport (PDK), a large general aviation airport north of Atlanta, Georgia. Increased aircraft operations were expected in nighttime hours due to the Olympic Games in Atlanta in July/August 1996. Indoor and outdoor measurements of aircraft and other nighttime noises were made in 12 homes in a community north of PDK for a period of approximately 6 weeks, beginning 2-1/2 weeks prior to the Olympics and ending one week after their conclusion. Sleep disturbance information suitable for analysis was measured during 686 subject-nights by self-report, behaviorally-confirmed awakening (button pushes upon awakening) and sleep motility (via a wrist-worn recording accelerometer). No major differences were noted in sleep disturbance during or after the Olympics. Inclusion of data from all time periods with results of prior studies did not affect a prior dosage-response relationship between awakening and sound exposure level. A subsequent study involving an additional 117 subject-nights was undertaken to compare the sensitivity and interpretability of sleep motility measurements made in analysis epochs ranging from 2 to 30 seconds in duration. The pattern of findings of the methodological study revealed little benefit of analyzing motility measurements in short duration epochs.
- Published
- 1998
20. Effects of aircraft overflights on wilderness recreationists
- Author
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Thomas Buchanan, Richard Howe, Karl S. Pearsons, Richard C. Knopf, James H. Gramann, Sanford Fidell, Laura Silvati, and Barbara G. Tabachnick
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Acoustics and Ultrasonics ,Aircraft noise ,Aircraft ,Noise pollution ,media_common.quotation_subject ,Annoyance ,Acoustics ,Direct measure ,Geography ,Noise exposure ,Arts and Humanities (miscellaneous) ,Environmental health ,Humans ,Wilderness ,Noise ,Recreation ,media_common ,Wilderness area - Abstract
On‐site and telephone opinion surveys were conducted to assess outdoor recreationists’ annoyance with aircraft overflights of wilderness areas. Although current technology for measuring noise exposure does not yet permit accurate and cost‐effective estimates of dosage‐response relationships in outdoor recreational settings, it was nonetheless possible to construct a rough relationship between estimated aircraft noise exposure and annoyance from the data of the on‐site study. In the second survey, telephone interviews were administered to another sample of outdoor recreationists within 2 weeks of their return from visits to 12 wilderness areas. The prevalence of aircraft noise‐induced annoyance (in any degree) among respondents in all wilderness areas ranged from 5% to 32%. The prevalence of a consequential degree of aircraft noise‐induced annoyance among respondents was less than 5% in all wilderness areas combined. Noise‐induced annoyance proved to be a more direct measure of the effects of aircraft overflights on recreationists than more global measures such as visit satisfaction or intent to revisit.
- Published
- 1996
21. Comparison of noise metrics for predicting the annoyance of aircraft overflight noise
- Author
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Richard Howe, Karl S. Pearsons, Sanford Fidell, Laura Silvati, and Matthew Sneddon
- Subjects
Background noise ,Noise ,Acoustics and Ultrasonics ,Arts and Humanities (miscellaneous) ,Anechoic chamber ,Aircraft noise ,Computer science ,Acoustics ,Active listening ,Annoyance ,Psychoacoustics ,Loudness - Abstract
Two groups of 30 audiometrically screened test participants judged the relative annoyance of two comparison (variable level) signals and 30–34 standard (fixed level) signals in an adaptive paired comparison psychoacoustic study. The signal ensemble included primarily stage II and stage III aircraft overflights, as well as synthesized aircraft noise signatures. Test signals were presented for judgment as heard indoors (test 1) and outdoors (test 2), in the presence of continuous background noise, under free‐field listening conditions in an anechoic chamber. For both tests, analyses of the performance of 30 noise metrics as predictors of these annoyance judgments confirmed that the more complex metrics were generally more accurate and precise predictors than the simpler methods. EPNL was slightly less accurate and precise as a predictor of the annoyance judgments than a duration‐adjusted variant of Zwicker’s loudness level. [Research was supported by NASA, Langley Research Center, Hampton, Virginia.]
- Published
- 1997
22. Insufficiency of an environmental sound's power spectrum as a predictor of its annoyance
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Sanford Fidell, Matthew Sneddon, Richard Howe, and Karl S. Pearsons
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geography ,geography.geographical_feature_category ,Acoustics and Ultrasonics ,Mechanical Engineering ,Acoustics ,Public Health, Environmental and Occupational Health ,Aerospace Engineering ,Spectral density ,Annoyance ,Building and Construction ,Industrial and Manufacturing Engineering ,Automotive Engineering ,Environmental science ,Sound (geography) - Published
- 2002
23. Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data.
- Author
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Richard Howey, So-Youn Shin, Caroline Relton, George Davey Smith, and Heather J Cordell
- Subjects
Genetics ,QH426-470 - Abstract
Mendelian randomization (MR) implemented through instrumental variables analysis is an increasingly popular causal inference tool used in genetic epidemiology. But it can have limitations for evaluating simultaneous causal relationships in complex data sets that include, for example, multiple genetic predictors and multiple potential risk factors associated with the same genetic variant. Here we use real and simulated data to investigate Bayesian network analysis (BN) with the incorporation of directed arcs, representing genetic anchors, as an alternative approach. A Bayesian network describes the conditional dependencies/independencies of variables using a graphical model (a directed acyclic graph) with an accompanying joint probability. In real data, we found BN could be used to infer simultaneous causal relationships that confirmed the individual causal relationships suggested by bi-directional MR, while allowing for the existence of potential horizontal pleiotropy (that would violate MR assumptions). In simulated data, BN with two directional anchors (mimicking genetic instruments) had greater power for a fixed type 1 error than bi-directional MR, while BN with a single directional anchor performed better than or as well as bi-directional MR. Both BN and MR could be adversely affected by violations of their underlying assumptions (such as genetic confounding due to unmeasured horizontal pleiotropy). BN with no directional anchor generated inference that was no better than by chance, emphasizing the importance of directional anchors in BN (as in MR). Under highly pleiotropic simulated scenarios, BN outperformed both MR (and its recent extensions) and two recently-proposed alternative approaches: a multi-SNP mediation intersection-union test (SMUT) and a latent causal variable (LCV) test. We conclude that BN incorporating genetic anchors is a useful complementary method to conventional MR for exploring causal relationships in complex data sets such as those generated from modern "omics" technologies.
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- 2020
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24. Design of a large‐scale, in‐home study of noise‐induced sleep disturbance
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Lawrence S. Finegold, Richard Howe, Sanford Fidell, and Karl S. Pearsons
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Sleep disorder ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Noise induced ,Work (physics) ,Audiology ,medicine.disease ,Noise ,Noise exposure ,Arts and Humanities (miscellaneous) ,Scale (social sciences) ,medicine ,Sleep (system call) ,Home study ,Psychology - Abstract
Pearsons, Barber, and Tabachnick (1990) have documented large differences in the findings of laboratory and home studies of the ability of noise to disturb sleep. More recently, preliminary analyses of data collected in a large‐scale, in‐home study of sleep disturbance [Ollerhead et al. (1992)] suggest a lower probability of awakening than indicated by a dosage–response relationship recommended by Federal Interagency Committee on Noise [FICON (1992)]. The U.S. Air Force is currently conducting an in‐home study of sleep disturbance, intended in part to clarify several issues not fully resolved in prior work. These include the definition of sleep disturbance and the temporal linkage between noise exposure and sleep disturbance. The rationale, design, and progress of the Air Force study are described.
- Published
- 1993
25. Causal modeling in a multi-omic setting: insights from GAW20
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Jonathan Auerbach, Richard Howey, Lai Jiang, Anne Justice, Liming Li, Karim Oualkacha, Sergi Sayols-Baixeras, and Stella W. Aslibekyan
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Genomics ,Epigenomics ,Causal inference ,Mendelian randomization ,Bayesian networks ,Structural equation modeling ,Genetics ,QH426-470 - Abstract
Abstract Background Increasingly available multilayered omics data on large populations has opened exciting analytic opportunities and posed unique challenges to robust estimation of causal effects in the setting of complex disease phenotypes. The GAW20 Causal Modeling Working Group has applied complementary approaches (eg, Mendelian randomization, structural equations modeling, Bayesian networks) to discover novel causal effects of genomic and epigenomic variation on lipid phenotypes, as well as to validate prior findings from observational studies. Results Two Mendelian randomization studies have applied novel approaches to instrumental variable selection in methylation data, identifying bidirectional causal effects of CPT1A and triglycerides, as well as of RNMT and C6orf42, on high-density lipoprotein cholesterol response to fenofibrate. The CPT1A finding also emerged in a Bayesian network study. The Mendelian randomization studies have implemented both existing and novel steps to account for pleiotropic effects, which were independently detected in the GAW20 data via a structural equation modeling approach. Two studies estimated indirect effects of genomic variation (via DNA methylation and/or correlated phenotypes) on lipid outcomes of interest. Finally, a novel weighted R2 measure was proposed to complement other causal inference efforts by controlling for the influence of outlying observations. Conclusions The GAW20 contributions illustrate the diversity of possible approaches to causal inference in the multi-omic context, highlighting the promises and assumptions of each method and the benefits of integrating both across methods and across omics layers for the most robust and comprehensive insights into disease processes.
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- 2018
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26. Influence of low‐frequency content on rate of growth of annoyance of high‐energy impulsive sounds
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Richard Howe, Karl S. Pearsons, Stephen J. Lind, Sanford Fidell, and Laura Silvati
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Noise ,High energy ,Test facility ,Acoustics and Ultrasonics ,Arts and Humanities (miscellaneous) ,Octave band ,Acoustics ,Environmental science ,Annoyance ,Low frequency ,Rate of growth ,Sonic boom - Abstract
Various ‘‘corrections’’ have been suggested to measures of high‐energy impulsive sounds to account for their seemingly anomalous annoyance, some on the basis of the findings of studies that may not have accurately reproduced the low‐frequency content of high‐energy impulses. The present study measured rates of growth of annoyance of impulsive and nonimpulsive sounds by adaptive paired comparisons of the annoyance of five variable level signals and 29 impulsive and nonimpulsive fixed level signals. All test sounds were presented for judgment in a specially designed low‐frequency test facility. When the annoyance of an aircraft flyover was compared to that of a low‐frequency band of noise and of sonic booms accompanied by rattle, the relative rates of growth of annoyance were not much different from 1:1. When the annoyance of sonic booms that were not accompanied by rattle was compared with that of sounds containing more higher‐frequency energy (an aircraft flyover and an octave band of noise centered at 1 ...
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- 1998
27. Initial results of study of aircraft noise effects on residential sleep disturbance
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David S. Barber, Sanford Fidell, Richard Howe, Barbara G. Tabachnick, Karl S. Pearsons, and Laura Silvati
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Sound exposure ,Noise ,Sleep disorder ,Acoustic testing ,Acoustics and Ultrasonics ,Arts and Humanities (miscellaneous) ,Aircraft noise ,Meteorology ,Noise pollution ,medicine ,Environmental science ,Occupational exposure ,medicine.disease - Abstract
More than 1800 subject‐nights of observations have been completed in a large‐scale, in‐home study of awakenings associated with nighttime aircraft noise exposure in the vicinity of an Air Force base, a major civil airport, and several sites in urban neighborhoods with negligible nighttime aircraft noise exposure. A statistically reliable relationship was found between behaviorally confirmed awakenings and indoor sound exposure of individual noise events. This relationship is similar to one reported in another recent large‐scale field study, and also with a relationship summarizing the findings of several earlier field studies of noise‐induced sleep disturbance. The findings do not, however, agree well with those typically found in laboratory studies of sleep disturbance, nor with an interim dosage‐response relationship adopted by the Federal Interagency Committee on Noise. [Research sponsored by U.S. Air Force Armstrong Laboratory, Wright‐Patterson Air Force Base, OH.]
- Published
- 1994
28. Review
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Margaret Anderson, David Lowenthal, Richard Howe, David Gray, Nancy Stedman, Brian Goodey, and Mark Leaf
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Geography, Planning and Development ,Management, Monitoring, Policy and Law ,Nature and Landscape Conservation ,General Environmental Science - Published
- 1988
29. Further investigations of the W-test for pairwise epistasis testing [version 1; referees: 2 approved]
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Richard Howey and Heather J. Cordell
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Bioinformatics ,Genomics ,Statistical Methodologies & Health Informatics ,Medicine ,Science - Abstract
Background: In a recent paper, a novel W-test for pairwise epistasis testing was proposed that appeared, in computer simulations, to have higher power than competing alternatives. Application to genome-wide bipolar data detected significant epistasis between SNPs in genes of relevant biological function. Network analysis indicated that the implicated genes formed two separate interaction networks, each containing genes highly related to autism and neurodegenerative disorders. Methods: Here we investigate further the properties and performance of the W-test via theoretical evaluation, computer simulations and application to real data. Results: We demonstrate that, for common variants, the W-test is closely related to several existing tests of association allowing for interaction, including logistic regression on 8 degrees of freedom, although logistic regression can show inflated type I error for low minor allele frequencies, whereas the W-test shows good/conservative type I error control. Although in some situations the W-test can show higher power, logistic regression is not limited to tests on 8 degrees of freedom but can instead be taylored to impose greater structure on the assumed alternative hypothesis, offering a power advantage when the imposed structure matches the true structure. Conclusions: The W-test is a potentially useful method for testing for association - without necessarily implying interaction - between genetic variants disease, particularly when one or more of the genetic variants are rare. For common variants, the advantages of the W-test are less clear, and, indeed, there are situations where existing methods perform better. In our investigations, we further uncover a number of problems with the practical implementation and application of the W-test (to bipolar disorder) previously described, apparently due to inadequate use of standard data quality-control procedures. This observation leads us to urge caution in interpretation of the previously-presented results, most of which we consider are highly likely to be artefacts.
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- 2017
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30. Sheep movement networks and the transmission of infectious diseases.
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Victoriya V Volkova, Richard Howey, Nicholas J Savill, and Mark E J Woolhouse
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Medicine ,Science - Abstract
Various approaches have been used to investigate how properties of farm contact networks impact on the transmission of infectious diseases. The potential for transmission of an infection through a contact network can be evaluated in terms of the basic reproduction number, R(0). The magnitude of R(0) is related to the mean contact rate of a host, in this case a farm, and is further influenced by heterogeneities in contact rates of individual hosts. The latter can be evaluated as the second order moments of the contact matrix (variances in contact rates, and co-variance between contacts to and from individual hosts). Here we calculate these quantities for the farms in a country-wide livestock network: >15,000 Scottish sheep farms in each of 4 years from July 2003 to June 2007. The analysis is relevant to endemic and chronic infections with prolonged periods of infectivity of affected animals, and uses different weightings of contacts to address disease scenarios of low, intermediate and high animal-level prevalence.Analysis of networks of Scottish farms via sheep movements from July 2003 to June 2007 suggests that heterogeneities in movement patterns (variances and covariances of rates of movement on and off the farms) make a substantial contribution to the potential for the transmission of infectious diseases, quantified as R(0), within the farm population. A small percentage of farms (80%) and these farms could be efficiently targeted by interventions aimed at reducing spread of diseases via animal movement.
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- 2010
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31. Fertility Preservation for Cancer Patients: A Review
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Tosin Ajala, Junaid Rafi, Peter Larsen-Disney, and Richard Howell
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Gynecology and obstetrics ,RG1-991 - Abstract
Infertility can arise as a consequence of treatment of oncological conditions. The parallel and continued improvement in both the management of oncology and fertility cases in recent times has brought to the fore-front the potential for fertility preservation in patients being treated for cancer. Oncologists must be aware of situations where their treatment will affect fertility in patients who are being treated for cancer and they must also be aware of the pathways available for procedures such as cryopreservation of gametes and/or embryos. Improved cancer care associated with increased cure rates and long term survival, coupled with advances in fertility treatment means that it is now imperative that fertility preservation is considered as part of the care offered to these patients. This can only be approached within a multidisciplinary setting. There are obvious challenges that still remain to be resolved, especially in the area of fertility preservation in prepubertal patients. These include ethical issues, such as valid consent and research in the area of tissue retrieval, cryopreservation, and transplantation.
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- 2010
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32. Passatempo al Cembalo, Sonate
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Richard Howe, Baldassare Galuppi, and Franco Piva
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Library and Information Sciences ,Music - Published
- 1969
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