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BackgroundWhite matter hyperintensities (WMH), identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness, are a major risk factor of stroke, dementia, and death. There are no large-scale studies testing associations between WMH and circulating metabolites.MethodsWe studied up to 9290 individuals (50.7% female, average age 61 years) from 15 populations of 8 community-based cohorts. WMH volume was quantified from T2-weighted or fluid-attenuated inversion recovery images or as hypointensities on T1-weighted images. Circulating metabolomic measures were assessed with mass spectrometry and nuclear magnetic resonance spectroscopy. Associations between WMH and metabolomic measures were tested by fitting linear regression models in the pooled sample and in sex-stratified and statin treatment-stratified subsamples. Our basic models were adjusted for age, sex, age×sex, and technical covariates, and our fully adjusted models were also adjusted for statin treatment, hypertension, type 2 diabetes, smoking, body mass index, and estimated glomerular filtration rate. Population-specific results were meta-analyzed using the fixed-effect inverse variance-weighted method. Associations with false discovery rate (FDR)-adjusted P values (PFDR)

Eomysticetidae are a clade of early diverging functionally toothless, longirostrine and likely baleen-bearing stem mysticete whales. Eomysticetid fossils are rare but known worldwide from Oligocene strata. The richest assemblage of eomysticetids has been uncovered in New Zealand from the Kokoamu Greensand and Otekaike Limestone (North Otago and South Canterbury regions, South Island). This includes some of the largest known eomysticetids, Tokarahia kauaeroa and Tokarahia lophocephalus, some older and more archaic forms such as Matapanui waihao, the fragmentary Tohoraata raekohao and Tohoraata waitakiensis, and the well-known Waharoa ruwhenua represented by several well-preserved skulls and mandibles of adults and juveniles. Studies of these New Zealand fossils strongly indicates monophyly of Eomysticetidae and suggest possible skim feeding behaviour, possession of non-functional teeth and baleen, extreme rostral lengthening during growth and peramorphic evolution, rostral kinesis, use of Zealandia as a calving ground, and probable extinction at or near the Oligo-Miocene boundary. [ABSTRACT FROM AUTHOR]

The Late Oligocene is a period of high penguin diversity, following major changes in the marine environment at the Eocene/Oligocene boundary and prior to the emergence of crown penguins in the Miocene. Historically, a large morphological gap existed between the most crownward Platydyptes among the Oligocene penguins from New Zealand and the Early Miocene stem penguins such as Palaeospheniscus from South America. Here we describe a new species that contributes to filling this gap. Pakudyptes hakataramea gen. et sp. nov. is the earliest tiny penguin, overlapping in size with the little penguin Eudyptula minor. Its distinctive combination of a well-developed proximal end of the humerus and an archaic elbow joint provides clues to the evolution of penguin wings. Phylogenetic analysis indicates that penguin wings evolved rapidly from the Late Oligocene to the Early Miocene, together with the acquisition of morphofunctional and hydrodynamical characteristics that enable the excellent swimming ability of modern penguins. As an indicator of aquatic adaptation, bone microanatomy shows a comparable structure to that of Eudyptula. The appearance of the smallest body size and the evolution of modern wings may have led to the ecological diversity of modern penguins, which confirms the importance of Zealandia in penguin evolution. [ABSTRACT FROM AUTHOR]

Albatrosses are among the most intensely studied groups of living birds, yet their fossil record remains sparse. Despite modern albatrosses being more abundant and widespread in the Southern Hemisphere, the vast majority of fossil albatrosses identified to date come from Northern Hemisphere localities. Here, we describe Plotornis archaeonautes sp. nov., a new albatross species from the earliest Miocene that represents the earliest record of Procellariiformes in New Zealand and the earliest uncontroversial record of the clade Pan-Diomedeidae from the Southern Hemisphere. Phylogenetic analyses support the placement of Plotornis outside of the clade uniting all extant albatrosses. The new fossil reveals that stem lineage albatrosses were widespread by the onset of the Neogene. Although the humerus of Plotornis archaeonautes exhibits a short processus supracondylaris dorsalis, this early species may have possessed at least one of the unique ossifications associated with the patagial bracing system present in modern albatrosses. [ABSTRACT FROM AUTHOR]

The 47 vertebrate type specimens held in the University of Otago Geology Department are catalogued in detail. A short history of the collection is followed by lists of the type specimens under the Classes Actinopterygii, Reptilia, Aves and Mammalia. A fish trace-fossil is included at the end of the Actinopterygii. Where appropriate, the name changes of the genus or species are given in chronological order. The specimens are briefly described, locality and geological age information is provided. [ABSTRACT FROM AUTHOR]

The fossil record of the genus Carcharodon (Lamniformes: Lamnidae) dates to the late Oligocene and has a near global distribution. Today the genus is represented by a single species, the white shark Carcharodon carcharias. However, multiple extinct species are recognised in the Cenozoic including Carcharodon hastalis, Carcharodon hubbelli and Carcharodon planus comb. nov. Here we present the first occurrences of Carcharodon hubbelli and Carcharodon planus from New Zealand/Aotearoa, from the South Island/Te Waipounamu. Carcharodon hubbelli is previously reported from late Miocene deposits in the Pacific basin of North and South America, Asia, and Australia. Whereas Carcharodon planus has been reported from the Miocene of North America and Asia. One tooth from Carcharodon hubbelli is reported from the presumed late Miocene of Motunau Beach, North Canterbury, while one upper early Miocene tooth recovered from the Kakahu River, South Canterbury and an earliest Miocene tooth from the Big River mouth, Tasman District are referred to Carcharodon planus. In addition to being the first reported occurrences of these two species in New Zealand, the teeth of Carcharodon planus represent some of the earliest occurrences of the taxon as well as its southernmost occurrence. [ABSTRACT FROM AUTHOR]

In March, 2019, a trackway of seven footprints was found at a riverbank outcrop of Maniototo Conglomerate Formation in the Kyeburn River, Central Otago, South Island, New Zealand. In this study, we describe this first known occurrence of moa (Dinornithiformes) footprints to be found and recovered in Te Waipounamu/South Island. Footprints of the trackway were ∼46 mm deep, 272–300 mm wide and 260–294 mm in length. An associated separate footprint was 448 mm wide and 285 mm long. Cosmogenic nuclide dating of adjacent overlying beds from the same formation establishes a mean minimum age of burial age for the tracks of 3.57 Ma (+1.62/−1.18 Ma) with a mode of 2.9 Ma, which we interpret to be Late Pliocene, with a conservative age range of Pliocene to Early Pleistocene. The trackway maker is identified as a moa from the Emeidae family, probably from the genus Pachyornis, with a mean mass of 84.61 kg that was travelling at a speed of 2.61 kmh−1. The single adjacent footprint was made by an individual from the family Dinornithidae, most likely from the genus Dinornis with an estimated mass of 158 kg. These moa footprints represent the second earliest fossil record of moa. [ABSTRACT FROM AUTHOR]

The earliest Miocene (Aquitanian, 23–20 Ma) remains a critically under-sampled 'dark age' in cetacean evolution. This is especially true of baleen whales (mysticetes), Aquitanian specimens of which remain almost entirely unknown. Across the globe, the nature of the cetacean fossil record radically shifts at the Oligocene-Miocene boundary, with mysticetes and some archaic odontocete lineages suddenly disappearing despite the availability of cetacean-bearing rock units. New Zealand is the only place worldwide where this change is not readily apparent, with baleen whales apparently persisting into the earliest Miocene. Whether this is a genuine pattern has so far remained obscured by a lack of biostratigraphic resolution associated with the Oligo-Miocene boundary. Here, we report 23 new strontium (87Sr/86Sr) dates from Lentipecten shells associated with 16 mysticete and seven odontocete specimens, respectively. Of these, eight fall within the Early Miocene and seven – including five mysticetes – specifically within the Aquitanian. Our findings confirm the unique nature and global importance of the cetacean fossil record from New Zealand, and provide a foundation for investigations into the causes and effects of the Early Miocene cetacean 'dark age'. [ABSTRACT FROM AUTHOR]

Background Growing evidence suggests that population mental health outcomes have worsened since the pandemic started. The extent that these changes have altered common age-related trends in psychological distress, where distress typically rises until midlife and then falls after midlife in both sexes, is unknown. We aimed to analyse whether long-term pre-pandemic psychological distress trajectories were disrupted during the pandemic, and whether these changes have been different across cohorts and by sex. Methods and findings We used data from three nationally representative birth cohorts comprising all people born in Great Britain in a single week of 1946 (National Survey of Health and Development, NSHD), 1958 (National Child Development Study, NCDS), or 1970 (British Cohort Study, BCS70). The follow-up data used spanned 39 years in NSHD (1982 to 2021), 40 years in NCDS (1981 to 2001), and 25 years in BCS70 (1996 to 2021). We used psychological distress factor scores, as measured by validated self-reported questionnaires (NSHD: Present State Examination, Psychiatric Symptoms Frequency, and 28- and 12-item versions of General Health Questionnaire; NCDS and BCS70: Malaise Inventory; all: 2-item versions of Generalized Anxiety Disorder scale and Patient Health Questionnaire). We used a multilevel growth curve modelling approach to model the trajectories of distress across cohorts and sexes and obtained estimates of the differences between the distress levels observed during the pandemic and those observed at the most recent pre-pandemic assessment and at the peak in the cohort-specific pre-pandemic distress trajectory, located at midlife. We further analysed whether pre-existing cohort and sex inequalities had changed with the pandemic onset using a difference-in-differences (DiD) approach. The analytic sample included 16,389 participants. By September/October 2020, distress levels had reached or exceeded the levels of the peak in the pre-pandemic life-course trajectories, with larger increases in younger cohorts (standardised mean differences [SMD] and 95% confidence intervals of SMD.sub.NSHD,pre-peak = -0.02 [-0.07, 0.04], SMD.sub.NCDS,pre-peak = 0.05 [0.02, 0.07], and SMD.sub.BCS70,pre-peak = 0.09 [0.07, 0.12] for the 1946, 1958, and 1970 birth cohorts, respectively). Increases in distress were larger among women than men, widening pre-existing sex inequalities (DiD and 95% confidence intervals of DiD.sub.NSHD,sex,pre-peak = 0.17 [0.06, 0.28], DiD.sub.NCDS,sex,pre-peak = 0.11 [0.07, 0.16], and DiD.sub.BCS70,sex,pre-peak = 0.11 [0.05, 0.16] when comparing sex inequalities in the pre-pandemic peak in midlife to those observed by September/October 2020). As expected in cohort designs, our study suffered from high proportions of attrition with respect to the original samples. Although we used non-response weights to restore sample representativeness to the target populations (those born in the United Kingdom in 1946, 1958, and 1970, alive and residing in the UK), results may not be generalisable to other sections within the UK population (e.g., migrants and ethnic minority groups) and countries different than the UK. Conclusions Pre-existing long-term psychological distress trajectories of adults born between 1946 and 1970 were disrupted during the COVID-19 pandemic, particularly among women, who reached the highest levels ever recorded in up to 40 years of follow-up data. This may impact future trends of morbidity, disability, and mortality due to common mental health problems., Author(s): Darío Moreno-Agostino 1,2,*, Helen L. Fisher 2,3, Alissa Goodman 1, Stephani L. Hatch 2,4, Craig Morgan 2,5, Marcus Richards 6, Jayati Das-Munshi 2,4,7, George B. Ploubidis 1,2 Introduction Mental [...]

INTRODUCTION: Limited observational windows lead to conflicting results in studies examining educational differences in Alzheimer's disease and related dementias (ADRD) risk, due to observational window bias relative to onset of accelerated cognitive decline. This study tested a novel model to address observational window bias and tested for the presence and sources of disparities in accelerated cognitive declines due to ADRD. METHODS: The sample examined 167,314 cognitive assessments from 32,441 Health and Retirement Study participants. We implemented a parametric non‐linear nested longitudinal regression and reported multivariable‐adjusted nodal incidence ratios (aNIR). RESULTS: University degrees were associated with lower incidence (aNIR = 0.253, 95% confidence interval [CI] = [0.221 to 0.289], p < 0.001), while black participants had a higher incidence (aNIR = 1.995, [1.858 to 2.141], p < 0.001) of accelerated cognitive decline, adjusting for demographic, sociobehavioral, and medical risk factors. Sex‐stratified analyses identified diminished educational returns for women and increased incidence among minoritized women. DISCUSSION: Addressing observational window bias reveals large social inequalities in the onset of accelerated cognitive declines indicative of ADRD. Highlights: This study identifies observational window bias as a source of conflicting results among previous studies of educational achievement in Alzheimer's disease and related dementias (ADRD) disparities.The study locates preclinical accelerated cognitive decline, which is indicative of ADRD while occurring 10+ years prior to symptom onset, as a site to study ADRD disparities that mitigates observational window bias.A novel method, nested non‐linear regression, is developed to test for differences in the onset of accelerated cognitive decline.Educational and racial/ethnic disparities are demonstrated in the onset of accelerated cognitive decline, as are their intersecting differences with sex/gender. [ABSTRACT FROM AUTHOR]