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25 results on '"Richey, Justin"'

1. Data from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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2. Supplementary Video 2 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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3. Supplementary Methods from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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4. Supplementary Video 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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5. Supplementary Video 4 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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6. Supplementary Figure and Movie Legends from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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7. Supplementary Figure 3 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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8. Supplementary Figure 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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9. Supplementary Figure 2 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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10. Supplementary Video 3 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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19. Topical Application of a Platelet Activating Factor Receptor Agonist Suppresses Phorbol Ester-Induced Acute and Chronic Inflammation and Has Cancer Chemopreventive Activity in Mouse Skin

Author

Sahu, Ravi P., primary, Rezania, Samin, additional, Ocana, Jesus A., additional, DaSilva-Arnold, Sonia C., additional, Bradish, Joshua R., additional, Richey, Justin D., additional, Warren, Simon J., additional, Rashid, Badri, additional, Travers, Jeffrey B., additional, and Konger, Raymond L., additional

Published
2014
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20. The Expression Patterns of p53 and p16 and an Analysis of a Possible Role of HPV in Primary Adenocarcinoma of the Urinary Bladder

Author

Alexander, Riley E., primary, Williamson, Sean R., additional, Richey, Justin, additional, Lopez-Beltran, Antonio, additional, Montironi, Rodolfo, additional, Davidson, Darrell D., additional, Idrees, Muhammad T., additional, Jones, Carol L., additional, Zhang, Shaobo, additional, Wang, Lisha, additional, Rao, Qiu, additional, Pedrosa, Jose A., additional, Kaimakliotis, Hristos Z., additional, Monn, M. Francesca, additional, Koch, Michael O., additional, and Cheng, Liang, additional

Published
2014
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22. CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, additional, Pei, Xin-Yan, additional, Myers, Jennifer, additional, Wang, Li, additional, Kramer, Lora B., additional, Garnett, Mandy, additional, Schwartz, Daniella M., additional, Su, Florence, additional, Simmons, Gary L., additional, Richey, Justin D., additional, Larsen, Dustin G., additional, Dent, Paul, additional, Orlowski, Robert Z., additional, and Grant, Steven, additional

Published
2012
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23. Abstract 4649: Nbk/Bik induced by flavopiridol switches GX15-070-induced autophagy to apoptosis in human multiple myeloma cells

Author

Dai, Yun, primary, Chen, Shuang, additional, Wang, Li, additional, Pei, Xin-Yan, additional, Myers, Jennifer, additional, Schwartz, Daniella, additional, Thompson, Nadine, additional, Larsen, Dustin, additional, Richey, Justin, additional, Su, Florence, additional, Orlowski, Robert Z., additional, and Grant, Steven, additional

Published
2012
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24. CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies.

Author

Shuang Chen, Yun Dai, Xin-Yan Pei, Myers, Jennifer, Li Wang, Kramer, Lora B., Garnett, Mandy, Schwartz, Daniella M., Su, Florence, Simmons, Gary L., Richey, Justin D., Larsen, Dustin G., Dent, Paul, Orlowski, Robert Z., and Grant, Steven

Subjects
*CYCLIN-dependent kinase inhibitors, *PROTEIN research, *MULTIPLE myeloma, *PHARMACODYNAMICS, *APOPTOSIS, *GENETIC transcription
Abstract

BH3 mimetic drugs induce cell death by antagonizing the activity of antiapoptotic Bcl-2 family proteins. Cyclindependent kinase (CDK) inhibitors that function as transcriptional repressors downregulate the Bcl-2 family member Mcl-1 and increase the activity of selective BH3 mimetics that fail to target this protein. In this study, we determined whether CDK inhibitors potentiate the activity of pan-BH3 mimetics directly neutralizing Mcl-1. Specifically, we evaluated interactions between the prototypical pan-CDK inhibitor flavopiridol and the pan-BH3 mimetic obatoclax in multiple myeloma (MM) cells in which Mcl-1 is critical for survival. Coadministration of flavopiridol and obatoclax synergistically triggered apoptosis in both drug-naïve and drug-resistant MM cells. Mechanistic investigations revealed that flavopiridol inhibited Mcl-1 transcription but increased transcription of Bim and its binding to Bcl-2/Bcl-xL. Obatoclax prevented Mcl-1 recovery and caused release of Bim from Bcl-2/Bcl-xL and Mcl-1, accompanied by activation of Bax/Bak. Whether administered singly or in combination with obatoclax, flavopiridol also induced upregulation of multiple BH3-only proteins, including BimEL, BimL, Noxa, and Bik/NBK. Notably, short hairpin RNA knockdown of Bim or Noxa abrogated lethality triggered by the flavopiridol/obatoclax combination in vitro and in vivo. Together, our findings show that CDK inhibition potentiates pan-BH3 mimetic activity through a cooperative mechanism involving upregulation of BH3-only proteins with coordinate downregulation of their antiapoptotic counterparts. These findings have immediate implications for the clinical trial design of BH3 mimetic-based therapies that are presently being studied intensively for the treatment of diverse hematopoietic malignancies, including lethal multiple myeloma. [ABSTRACT FROM AUTHOR]

Published
2012
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25. Multiple atypical vascular lesions following breast-conserving surgery and radiation.

Author

Berrebi KG, Orlowski GM, Richey JD, and Levin NA

Subjects
Adult, Breast Neoplasms pathology, Combined Modality Therapy, Female, Humans, Breast Neoplasms therapy, Hemangiosarcoma prevention & control, Mastectomy methods, Mastectomy, Segmental methods
Abstract

Atypical vascular lesions (AVLs) of the breast are purple papules or nodules that have been reported in breast cancer patients following radiation treatment, typically presenting with fewer than 5 lesions at diagnosis. We report a patient with 29 lesions within previously irradiated breast tissue. Due to the large number of lesions and concern for development of angiosarcoma, the patient's case was brought before a multidisciplinary tumor board that decided she should undergo a radical mastectomy with flap reconstruction. We discuss the dermatologist's role in managing this complex and increasingly common disorder.

Published
2019

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