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2. PLCL/PCL Dressings with Platelet Lysate and Growth Factors Embedded in Fibrin for Chronic Wound Regeneration

Author

Táborská J, Blanquer A, Brynda E, Filová E, Stiborová L, Jenčová V, Havlíčková K, Riedelová Z, and Riedel T

Subjects
human platelet lysate, diabetic ulcer, fibrin coating, growth factors, nanofibers, bioactive dressing, Medicine (General), R5-920
Abstract

Johanka Táborská,1 Andreu Blanquer,2,3 Eduard Brynda,1 Elena Filová,2 Lenka Stiborová,1 Věra Jenčová,4 Kristýna Havlíčková,4 Zuzana Riedelová,1 Tomáš Riedel1 1Department of Chemistry and Physics of Surfaces and Biointerfaces, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, Czech Republic; 2Department of Biomaterials and Tissue Engineering, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic; 3Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, Bellaterra, Spain; 4Department of Chemistry, Technical University of Liberec, Liberec, Czech RepublicCorrespondence: Tomáš Riedel, Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho namesti 2, 162 00 Prague 6, Czech Republic, Tel +420 296 809 333, Email riedel@imc.cas.czIntroduction: The formation of diabetic ulcers (DU) is a common complication for diabetic patients resulting in serious chronic wounds. There is therefore, an urgent need for complex treatment of this problem. This study examines a bioactive wound dressing of a biodegradable electrospun nanofibrous blend of poly(L-lactide-co-ϵ-caprolactone) and poly(ϵ-caprolactone) (PLCL/PCL) covered by a thin fibrin layer for sustained delivery of bioactive molecules.Methods: Electrospun PLCL/PCL nanofibers were coated with fibrin-based coating prepared by a controlled technique and enriched with human platelet lysate (hPL), fibroblast growth factor 2 (FGF), and vascular endothelial growth factor (VEGF). The coating was characterized by scanning electron microscopy and fluorescent microscopy. Protein content and its release rate and the effect on human saphenous vein endothelial cells (HSVEC) were evaluated.Results: The highest protein amount is achieved by the coating of PLCL/PCL with a fibrin mesh containing 20% v/v hPL (NF20). The fibrin coating serves as an excellent scaffold to accumulate bioactive molecules from hPL such as PDGF-BB, fibronectin (Fn), and α-2 antiplasmin. The NF20 coating shows both fast and a sustained release of the attached bioactive molecules (Fn, VEGF, FGF). The dressing significantly increases the viability of human saphenous vein endothelial cells (HSVECs) cultivated on a collagen-based wound model. The exogenous addition of FGF and VEGF during the coating procedure further increases the HSVECs viability. In addition, the presence of α-2 antiplasmin significantly stabilizes the fibrin mesh and prevents its cleavage by plasmin.Discussion: The NF20 coating supplemented with FGF and VEGF provides a promising wound dressing for the complex treatment of DU. The incorporation of various bioactive molecules from hPL and growth factors has great potential to support the healing processes by providing appropriate stimuli in the chronic wound.Keywords: human platelet lysate, diabetic ulcer, fibrin coating, growth factors, nanofibers, bioactive dressing

Published
2023

3. Born into an isolating world: family-centred care for babies born to mothers with COVID-19

Author

Dowse, G., Perkins, E.J., Tingay, D.G., De Luca, D., Stein, H.M., Carvalho, W.B., Danhaive, O., Elsayed, Y., Chidini, G., Kneyber, M.C.J., MedinaVillanueva, A., Polito, A., Shoemaker, J., Piersigilli, B., Bekkouch, O., Rooze, S., Gonçalves Ferri, W.A., Oliveira, A.A., Morello, R., Krebs, V., Buonsenso, D., Valentini, P., Al-Naqeeb, N., Sabbour, S.M.H., Hegazi, A.E.A., Torpiano, P., Sammut, P., Pace, D., Vetter-Laracy, S., Roldán, M., Pilar-Orive, F.J., Rogdo, B., Cetinkaya, M., Yasa, B., Letamendia-Richard, E., Regiroli, G., Vivanti, A., Centorrino, R., Oliveira, N.F., Dittrich, M.H.M., Felgueira, R., Neves, C., Tissieres, P., Amigoni, A., Daverio, M., Tosoni, A., Andre, M.C., Wagner, B., Riedel, T., Rimensberger, P., Ramelet, A.-S., Perez, M.-H., Marston, M., Chanez, V., Longchamp, D., Natterer, J., Ferry, T., Brotschi, B., Elsayed, Y.N., AlNaqeeb, N., Medina, A., and Brouwer, C.N.M.

Published
2023
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4. Assessing forest availability for wood supply in Europe

Author

Alberdi, I., Bender, S., Riedel, T., Avitable, V., Boriaud, O., Bosela, M., Camia, A., Cañellas, I., Castro Rego, F., Fischer, C., Freudenschuß, A., Fridman, J., Gasparini, P., Gschwantner, T., Guerrero, S., Kjartansson, B.T., Kucera, M., Lanz, A., Marin, G., Mubareka, S., Notarangelo, M., Nunes, L., Pesty, B., Pikula, T., Redmond, J., Rizzo, M., Seben, V., Snorrason, A., Tomter, S., and Hernández, L.

Published
2020
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5. Equations for estimating belowground biomass of Silver Birch, Oak and Scots Pine in Germany

Author

Röhling S, Demant B, Dunger K, Neubauer M, Oehmichen K, Riedel T, and Stümer W

Subjects
Belowground Biomass, Allometric Equations, National Greenhouse Gas Inventory, Betula pendula, Quercus robur, Quercus petraea, Pinus sylvestris, Forestry, SD1-669.5
Abstract

In this study we derived allometric functions for estimating the belowground biomass (BGB) of Silver Birch (Betula pendula Roth), Pedunculate Oak (Quercus robur L.), Sessile Oak (Quercus petraea (Matt.) Liebl.) and Scots Pine (Pinus sylvestris L.) in Germany. To assess the impact on German greenhouse gas (GHG) reporting, these new functions were further compared with BGB functions currently used in France and Sweden. For developing new BGB functions 48 Silver Birches, 39 Pedunculate and Sessile Oaks and 54 Scots Pines were destructively sampled. The sampled trees spanned a DBH range from 8.2 to 52.9 cm for Silver Birch, from 7.4 to 42.0 cm for Oak and from 7.2 to 53.2 cm for Scots Pine. After fitting the data, the following values of model efficiency were achieved: 0.81 for Silver Birch, 0.98 for Oak and 0.95 for Scots Pine. The model root mean square error varies between 5.2 kg for Oak, 13.7 kg for Scots pine and 26.9 kg for Silver Birch. Comparison with the currently applied BGB functions in the German GHG inventory from France and Sweden showed that the use of these functions results in systematically different estimates for the BGB of Silver Birch and Oak. Thus, our findings indicate that BGB functions recommended for other European countries (in particular France and Sweden) are not appropriate for estimating the BGB for the tree species concerned in Germany. Currently, the derived data-set for BGB of Silver Birch, Oak and Scots Pine is the largest in Germany and the developed functions are thus the best available for estimating national BGB stock and stock change in Germany at the moment.

Published
2019
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9. Protein nanocoatings on synthetic polymeric nanofibrous membranes designed as carriers for skin cells

Author

Bacakova M, Pajorova J, Stranska D, Hadraba D, Lopot F, Riedel T, Brynda E, Zaloudkova M, and Bacakova L

Subjects
skin tissue engineering, nanocoating, nanofibers, skin cells, fibrin, collagen, Medicine (General), R5-920
Abstract

Marketa Bacakova,1,2 Julia Pajorova,1,2 Denisa Stranska,3 Daniel Hadraba,1,4 Frantisek Lopot,4 Tomas Riedel,5 Eduard Brynda,5 Margit Zaloudkova,6 Lucie Bacakova1 1Department of Biomaterials and Tissue Engineering, Institute of Physiology, Czech Academy of Sciences, 2Second Faculty of Medicine, Charles University, Prague, 3InStar Technologies, Liberec, 4Department of Anatomy and Biomechanics, Faculty of Physical Education and Sport, Charles University, 5Department of Chemistry and Physics of Surfaces and Biointerfaces, Institute of Macromolecular Chemistry, 6Department of Composites and Carbon Materials, Institute of Rock Structure and Mechanics, Czech Academy of Sciences, Prague, Czech Republic Abstract: Protein-coated resorbable synthetic polymeric nanofibrous membranes are promising for the fabrication of advanced skin substitutes. We fabricated electrospun polylactic acid and poly(lactide-co-glycolic acid) nanofibrous membranes and coated them with fibrin or collagen I. Fibronectin was attached to a fibrin or collagen nanocoating, in order further to enhance the cell adhesion and spreading. Fibrin regularly formed a coating around individual nanofibers in the membranes, and also formed a thin noncontinuous nanofibrous mesh on top of the membranes. Collagen also coated most of the fibers of the membrane and randomly created a soft gel on the membrane surface. Fibronectin predominantly adsorbed onto a thin fibrin mesh or a collagen gel, and formed a thin nanofibrous structure. Fibrin nanocoating greatly improved the attachment, spreading, and proliferation of human dermal fibroblasts, whereas collagen nanocoating had a positive influence on the behavior of human HaCaT keratinocytes. In addition, fibrin stimulated the fibroblasts to synthesize fibronectin and to deposit it as an extracellular matrix. Fibrin coating also showed a tendency to improve the ultimate tensile strength of the nanofibrous membranes. Fibronectin attached to fibrin or to a collagen coating further enhanced the adhesion, spreading, and proliferation of both cell types. Keywords: skin-tissue engineering, nanocoating, nanofibers, skin cells, fibrin, collagen

Published
2017

10. Correction to: Febrile illness in high-risk children: a prospective, international observational study (European Journal of Pediatrics, (2022), 182, 2, (543-554), 10.1007/s00431-022-04642-1)

Author

van der Velden, F.J.S. de Vries, G. Martin, A. Lim, E. von Both, U. Kolberg, L. Carrol, E.D. Khanijau, A. Herberg, J.A. De, T. Galassini, R. Kuijpers, T.W. Martinón-Torres, F. Rivero-Calle, I. Vermont, C.L. Hagedoorn, N.N. Pokorn, M. Pollard, A.J. Schlapbach, L.J. Tsolia, M. Elefhteriou, I. Yeung, S. Zavadska, D. Fink, C. Voice, M. Zenz, W. Kohlmaier, B. Agyeman, P.K.A. Usuf, E. Secka, F. de Groot, R. Levin, M. van der Flier, M. Emonts, M. Cunnington, A. Herberg, J. Kaforou, M. Wright, V. Baumard, L. Bellos, E. D’Souza, G. Habgood-Coote, D. Hamilton, S. Hoggart, C. Hourmat, S. Jackson, H. Maconochie, I. Menikou, S. Lin, N. Nichols, S. Nijman, R. Powell, O. Pena Paz, I. Shah, P. Shen, C.-F. Vito, O. Wilson, C. Abdulla, A. Ali, L. Darnell, S. Jorgensen, R. Mustafa, S. Persand, S. Stevens, M.M. Kim, N. Kim, E. Fidler, K. Dudley, J. Richmond, V. Tavliavini, E. Shen, C.-F. Liu, C.-C. Wang, S.-M. Salas, A. González, F.Á. Farto, C.B. Barral-Arca, R. Castro, M.´B. Bello, X. García, M.B. Carnota, S. Cebey-López, M. Curras-Tuala, M.J. Suárez, C.D. Vicente, L.G. Gómez-Carballa, A. Rial, J.G. Iglesias, P.L. Martinón-Torres, N. Sánchez, J.M.M. Pérez, B.M. Pardo-Seco, J. Rodríguez, L.P. Pischedda, S. Vázquez, S.R. Calle, I.R. Rodríguez-Tenreiro, C. Redondo-Collazo, L. Ora, M.S. Salas, A. Fernández, S.S. Trasorras, C.S. Iglesias, M.V. Balode, A. Barzdina, A. Deksne, D. Gardovska, D. Gravele, D. Grope, I. Meiere, A. Nokalna, I. Pavare, J. Pucuka, Z. Selecka, K. Rudzate, A. Svile, D. Urbane, U.N. Bojang, K. Zaman, S.M.A. Anderson, S. Sarr, A.R.I. Saidykhan, M. Darboe, S. Ceesay, S. D’alessandro, U. Moll, H.A. Vermont, C.L. Borensztajn, D.M. Tan, C. Zachariasse, J. Dik, W. Agyeman, P.K. Berger, C. Giannoni, E. Stocker, M. Posfay-Barbe, K.M. Heininger, U. Bernhard-Stirnemann, S. Niederer-Loher, A. Kahlert, C.R. Natalucci, G. Relly, C. Riedel, T. Aebi, C. Schlapbach, L.J. Carrol, E.D. Cocklin, E. Jennings, R. Johnston, J. Leigh, S. Lewis-Burke, N. Newall, K. Romaine, S. Eleftheriou, I. and van der Velden, F.J.S. de Vries, G. Martin, A. Lim, E. von Both, U. Kolberg, L. Carrol, E.D. Khanijau, A. Herberg, J.A. De, T. Galassini, R. Kuijpers, T.W. Martinón-Torres, F. Rivero-Calle, I. Vermont, C.L. Hagedoorn, N.N. Pokorn, M. Pollard, A.J. Schlapbach, L.J. Tsolia, M. Elefhteriou, I. Yeung, S. Zavadska, D. Fink, C. Voice, M. Zenz, W. Kohlmaier, B. Agyeman, P.K.A. Usuf, E. Secka, F. de Groot, R. Levin, M. van der Flier, M. Emonts, M. Cunnington, A. Herberg, J. Kaforou, M. Wright, V. Baumard, L. Bellos, E. D’Souza, G. Habgood-Coote, D. Hamilton, S. Hoggart, C. Hourmat, S. Jackson, H. Maconochie, I. Menikou, S. Lin, N. Nichols, S. Nijman, R. Powell, O. Pena Paz, I. Shah, P. Shen, C.-F. Vito, O. Wilson, C. Abdulla, A. Ali, L. Darnell, S. Jorgensen, R. Mustafa, S. Persand, S. Stevens, M.M. Kim, N. Kim, E. Fidler, K. Dudley, J. Richmond, V. Tavliavini, E. Shen, C.-F. Liu, C.-C. Wang, S.-M. Salas, A. González, F.Á. Farto, C.B. Barral-Arca, R. Castro, M.´B. Bello, X. García, M.B. Carnota, S. Cebey-López, M. Curras-Tuala, M.J. Suárez, C.D. Vicente, L.G. Gómez-Carballa, A. Rial, J.G. Iglesias, P.L. Martinón-Torres, N. Sánchez, J.M.M. Pérez, B.M. Pardo-Seco, J. Rodríguez, L.P. Pischedda, S. Vázquez, S.R. Calle, I.R. Rodríguez-Tenreiro, C. Redondo-Collazo, L. Ora, M.S. Salas, A. Fernández, S.S. Trasorras, C.S. Iglesias, M.V. Balode, A. Barzdina, A. Deksne, D. Gardovska, D. Gravele, D. Grope, I. Meiere, A. Nokalna, I. Pavare, J. Pucuka, Z. Selecka, K. Rudzate, A. Svile, D. Urbane, U.N. Bojang, K. Zaman, S.M.A. Anderson, S. Sarr, A.R.I. Saidykhan, M. Darboe, S. Ceesay, S. D’alessandro, U. Moll, H.A. Vermont, C.L. Borensztajn, D.M. Tan, C. Zachariasse, J. Dik, W. Agyeman, P.K. Berger, C. Giannoni, E. Stocker, M. Posfay-Barbe, K.M. Heininger, U. Bernhard-Stirnemann, S. Niederer-Loher, A. Kahlert, C.R. Natalucci, G. Relly, C. Riedel, T. Aebi, C. Schlapbach, L.J. Carrol, E.D. Cocklin, E. Jennings, R. Johnston, J. Leigh, S. Lewis-Burke, N. Newall, K. Romaine, S. Eleftheriou, I.

Abstract

In the original published version of the above article, the names of members of the PERFORM consortium were not introduced in the authorship section. The names are now properly displayed. The complete consortium list has been added as Supplementary material to the original article. The original article has been corrected. © 2023, The Author(s).

Published
2023

11. Ulnaschaftfraktur («Parierfraktur»), konservativ funktionell

Author

Schmidt, Jörg, Riedel, Tobias, Grundler, Stefan, Schmidt, J ( Jörg ), Riedel, T ( Tobias ), Grundler, S ( Stefan ), Heining, Sandro M; https://orcid.org/0000-0002-6085-2315, Schmidt, Jörg, Riedel, Tobias, Grundler, Stefan, Schmidt, J ( Jörg ), Riedel, T ( Tobias ), Grundler, S ( Stefan ), and Heining, Sandro M; https://orcid.org/0000-0002-6085-2315

Published
2023

12. Wann verordne ich was?

Author

Schmidt, Jörg, Riedel, Tobias, Grundler, Stefan, Schmidt, J ( Jörg ), Riedel, T ( Tobias ), Grundler, S ( Stefan ), Heining, Sandro M; https://orcid.org/0000-0002-6085-2315, Schmidt, Jörg, Riedel, Tobias, Grundler, Stefan, Schmidt, J ( Jörg ), Riedel, T ( Tobias ), Grundler, S ( Stefan ), and Heining, Sandro M; https://orcid.org/0000-0002-6085-2315

Published
2023

13. The potential applications of fibrin-coated electrospun polylactide nanofibers in skin tissue engineering

Author

Bacakova M, Musilkova J, Riedel T, Stranska D, Brynda E, Zaloudkova M, and Bacakova L

Subjects
nanofibers, skin tissue engineering, fibroblasts, fibrin, collagen, ascorbic acid, Medicine (General), R5-920
Abstract

Marketa Bacakova,1,2 Jana Musilkova,1 Tomas Riedel,3 Denisa Stranska,4 Eduard Brynda,3 Margit Zaloudkova,5 Lucie Bacakova1 1Department of Biomaterials and Tissue Engineering, Institute of Physiology, Czech Academy of Sciences, 2Second Faculty of Medicine, Charles University in Prague, 3Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague, 4InStar Technologies, Liberec, 5Institute of Rock Structure and Mechanics, Czech Academy of Sciences, Prague, Czech Republic Abstract: Fibrin plays an important role during wound healing and skin regeneration. It is often applied in clinical practice for treatment of skin injuries or as a component of skin substitutes. We prepared electrospun nanofibrous membranes made from poly(L-lactide) modified with a thin fibrin nanocoating. Fibrin surrounded the individual fibers in the membrane and also formed a thin fibrous mesh on several places on the membrane surface. The cell-free fibrin nanocoating remained stable in the cell culture medium for 14 days and did not change its morphology. On membranes populated with human dermal fibroblasts, the rate of fibrin degradation correlated with the degree of cell proliferation. The cell spreading, mitochondrial activity, and cell population density were significantly higher on membranes coated with fibrin than on nonmodified membranes, and this cell performance was further improved by the addition of ascorbic acid in the cell culture medium. Similarly, fibrin stimulated the expression and synthesis of collagen I in human dermal fibroblasts, and this effect was further enhanced by ascorbic acid. The expression of beta1-integrins was also improved by fibrin, and on pure polylactide membranes, it was slightly enhanced by ascorbic acid. In addition, ascorbic acid promoted deposition of collagen I in the form of a fibrous extracellular matrix. Thus, the combination of nanofibrous membranes with a fibrin nanocoating and ascorbic acid seems to be particularly advantageous for skin tissue engineering. Keywords: electrospun nanofibers, nanocoating, skin tissue engineering, fibroblasts, fibrin, ascorbic acid, nanotechnology, nanomedicine, collagen I synthesis, beta1-integrins

Published
2016

14. Pediatric neck rescue: randomized comparison of two emergency approaches to the trachea in an advanced simulated rabbit model

Author

Riva, T., Fuchs, A., Greif, R., Disma, N., Riedel, T., and Ulmer, F.

Subjects
610 Medicine & health
Abstract

Background and Goal of Study: The rapid-sequence-tracheotomy (RST) and the scalpel-bougie-tracheotomy (SBT) are two recently introduced approaches that have explored establishing emergency front of neck access (eFONA) in an unanticipated difficult paediatric airway situation using a rabbit cadaver as a simulator. The objective of this study was to assess the two techniques in a simulated environment with enhanced realism including operative haemorrhage. Materials and Methods: 30 doctors were allocated to two groups for this randomized controlled cross-over equivalence trial. Af ter watching an illustrated training video and practicing one of the eFONA techniques four times, participants performed one final tracheotomy which was video recorded and rated. This sequence was then repeated for the other eFONA technique. Randomization determined whether the RST or SBT-technique was done first. Primary outcome was the comparison of the performance times between two surgical rescue techniques. Secondary outcomes included success rate, structural injuries, and subjective participant self-evaluation of their performance. Rabbit cadavers were acquired commercially and had been slaughtered exclusively for food purposes in accordance with the Swiss law in the presence of the cantonal veterinarian of the canton of Aargau. Based on previous data, we chose an equivalence margin of Δ= ±10 seconds with respect to the duration of the procedure. Results and Discussion: The two techniques were not equivalent with respect to the predefined margin of +/- 10 seconds. The median-time difference of 11.0 (95% CI: -4.9 – 29.0) seconds serves as weak evidence suggesting shorter performance time for the the SBT, yet there was no significant difference between the performance times of the two techniques (p = 0.07). The overall success rate was 93.3% (CI: 83.8% – 98.2%). Participants expressed a significant highly preference for the SBT-technique (p < 0.001). The median performance time difference exceeded our equivalence margin of 10 seconds and therefore we did not find equivalency between the two techniques. Nonetheless there was no significant difference between the performance times of the two techniques. Conclusion(s): Previously inexperienced clinicians can acquire the skillset needed to perform eFONA in small children in about a minute, by watching training videos. Fewer tracheal injuries and participants’ indicated preferences may favour the SBT.

Published
2023
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17. Implicit Middleware : A Ubiquitous Abstract Machine

Author

Riedel, T., Beigl, M., Berchtold, M., Decker, C., Puder, A., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Meersman, Robert, editor, Tari, Zahir, editor, and Herrero, Pilar, editor

Published
2008
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18. OP052 [Infections » Sepsis]: VALIDATION OF PEDIATRIC ORGAN DYSFUNCTION SCORES IN CHILDREN WITH BLOODCULTURE PROVEN INFECTION – A NATIONAL PROSPECTIVE COHORT STUDY

Author

Schlapbach, L. J., primary, Goertz, S., additional, Hagenbuch, N., additional, Aubert, B., additional, Papis, S., additional, Giannoni, E., additional, Posfay Barbe, K. M., additional, Stocker, M., additional, Heininger, U., additional, Bernhard, S., additional, Niederer Loher, A., additional, Kahlert, C., additional, Natalucci, G., additional, Relly, C., additional, Riedel, T., additional, Aebi, C., additional, Berger, C., additional, and Agyeman, P., additional

Published
2022
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20. Prediction of recovery from multiple organ dysfunction syndrome in pediatric sepsis patients

Author

Fan, B., Klatt, J., Moor, M., Daniels, L., Swiss Pediatric Sepsis, S., Agyeman, P., Berger, C., Giannoni, E., Stocker, M., Posfay-Barbe, K., Heininger, U., Bernhard-Stirnemann, S., Niederer-Loher, A., Kahlert, C., Natalucci, G., Relly, C., Riedel, T., Aebi, C., Schlapbach, L., Sanchez-Pinto, L., and Borgwardt, K.

Subjects
Statistics and Probability, Multiple Organ Failure, 610 Medicine & health, Intensive Care Units, Pediatric, Biochemistry, Computer Science Applications, Cohort Studies, Computational Mathematics, Computational Theory and Mathematics, ROC Curve, Sepsis, Humans, Child, Molecular Biology
Abstract

Motivation Sepsis is a leading cause of death and disability in children globally, accounting for ∼3 million childhood deaths per year. In pediatric sepsis patients, the multiple organ dysfunction syndrome (MODS) is considered a significant risk factor for adverse clinical outcomes characterized by high mortality and morbidity in the pediatric intensive care unit. The recent rapidly growing availability of electronic health records (EHRs) has allowed researchers to vastly develop data-driven approaches like machine learning in healthcare and achieved great successes. However, effective machine learning models which could make the accurate early prediction of the recovery in pediatric sepsis patients from MODS to a mild state and thus assist the clinicians in the decision-making process is still lacking. Results This study develops a machine learning-based approach to predict the recovery from MODS to zero or single organ dysfunction by 1 week in advance in the Swiss Pediatric Sepsis Study cohort of children with blood-culture confirmed bacteremia. Our model achieves internal validation performance on the SPSS cohort with an area under the receiver operating characteristic (AUROC) of 79.1% and area under the precision-recall curve (AUPRC) of 73.6%, and it was also externally validated on another pediatric sepsis patients cohort collected in the USA, yielding an AUROC of 76.4% and AUPRC of 72.4%. These results indicate that our model has the potential to be included into the EHRs system and contribute to patient assessment and triage in pediatric sepsis patient care. Availability and implementation Code available at https://github.com/BorgwardtLab/MODS-recovery. The data underlying this article is not publicly available for the privacy of individuals that participated in the study. Supplementary information Supplementary data are available at Bioinformatics online.

Published
2022
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22. Guideline adherence in febrile children below 3 months visiting European Emergency Departments: an observational multicenter study

Author

Tan, C.D. van der Walle, E.E.P.L. Vermont, C.L. von Both, U. Carrol, E.D. Eleftheriou, I. Emonts, M. van der Flier, M. de Groot, R. Herberg, J. Kohlmaier, B. Levin, M. Lim, E. Maconochie, I.K. Martinon-Torres, F. Nijman, R.G. Pokorn, M. Rivero-Calle, I. Tsolia, M. Yeung, S. Zenz, W. Zavadska, D. Moll, H.A. Levin, M. Cunnington, A. De, T. Herberg, J. Kaforou, M. Wright, V. Baumard, L. Bellos, E. D’Souza, G. Galassini, R. Habgood-Coote, D. Hamilton, S. Hoggart, C. Hourmat, S. Jackson, H. Maconochie, I. Menikou, S. Lin, N. Nichols, S. Nijman, R. Pena Paz, I. Shah, P. Shen, C.-F. Vito, O. Wilson, C. Abdulla, A. Ali, L. Darnell, S. Jorgensen, R. Mustafa, S. Persand, S. Stevens, M. Kim, E. Pierce, B. Fidler, K. Dudley, J. Richmond, V. Tavliavini, E. Liu, C.-C. Wang, S.-M. Martinón-Torres, F. Salas, A. Álvez González, F. Balo Farto, C. Barral-Arca, R. Barreiro Castro, M. Bello, X. García, M.B. Carnota, S. Cebey-López, M. Curras-Tuala, M.J. Durán Suárez, C. García Vicente, L. Gómez-Carballa, A. Gómez Rial, J. Leboráns Iglesias, P. Martinón-Torres, F. Martinón-Torres, N. Martinón Sánchez, J.M. Mosquera Pérez, B. Pardo-Seco, J. Piñeiro Rodríguez, L. Pischedda, S. Vázquez, S.R. Rivero Calle, I. Rodríguez-Tenreiro, C. Redondo-Collazo, L. Sadiki Ora, M. Salas, A. Serén Fernández, S. Serén Trasorras, C. Vilas Iglesias, M. Zavadska, D. Balode, A. Bārzdiņa, A. Deksne, D. Gardovska, D. Grāvele, D. Grope, I. Meiere, A. Nokalna, I. Pavāre, J. Pučuka, Z. Selecka, K. Sidorova, A. Svile, D. Urbāne, U.N. Usuf, E. Bojang, K. Zaman, S.M.A. Secka, F. Anderson, S. Roca, A. Sarr, I. Saidykhan, M. Darboe, S. Ceesay, S. D’alessandro, U. Moll, H.A. Borensztajn, D.M. Hagedoorn, N.N. Tan, C. Vermont, C.L. Zachariasse, J. Dik, W. Agyeman, P. Schlapbach, L.J. Aebi, C. Wyss, V. Usman, M. Agyeman, P. Schlapbach, L.J. Giannoni, E. Stocker, M. Posfay-Barbe, K.M. Heininger, U. Bernhard-Stirnemann, S. Niederer-Loher, A. Kahlert, C. Natalucci, G. Relly, C. Riedel, T. Aebi, C. Berger, C. Carrol, E.D. Paulus and Tan, C.D. van der Walle, E.E.P.L. Vermont, C.L. von Both, U. Carrol, E.D. Eleftheriou, I. Emonts, M. van der Flier, M. de Groot, R. Herberg, J. Kohlmaier, B. Levin, M. Lim, E. Maconochie, I.K. Martinon-Torres, F. Nijman, R.G. Pokorn, M. Rivero-Calle, I. Tsolia, M. Yeung, S. Zenz, W. Zavadska, D. Moll, H.A. Levin, M. Cunnington, A. De, T. Herberg, J. Kaforou, M. Wright, V. Baumard, L. Bellos, E. D’Souza, G. Galassini, R. Habgood-Coote, D. Hamilton, S. Hoggart, C. Hourmat, S. Jackson, H. Maconochie, I. Menikou, S. Lin, N. Nichols, S. Nijman, R. Pena Paz, I. Shah, P. Shen, C.-F. Vito, O. Wilson, C. Abdulla, A. Ali, L. Darnell, S. Jorgensen, R. Mustafa, S. Persand, S. Stevens, M. Kim, E. Pierce, B. Fidler, K. Dudley, J. Richmond, V. Tavliavini, E. Liu, C.-C. Wang, S.-M. Martinón-Torres, F. Salas, A. Álvez González, F. Balo Farto, C. Barral-Arca, R. Barreiro Castro, M. Bello, X. García, M.B. Carnota, S. Cebey-López, M. Curras-Tuala, M.J. Durán Suárez, C. García Vicente, L. Gómez-Carballa, A. Gómez Rial, J. Leboráns Iglesias, P. Martinón-Torres, F. Martinón-Torres, N. Martinón Sánchez, J.M. Mosquera Pérez, B. Pardo-Seco, J. Piñeiro Rodríguez, L. Pischedda, S. Vázquez, S.R. Rivero Calle, I. Rodríguez-Tenreiro, C. Redondo-Collazo, L. Sadiki Ora, M. Salas, A. Serén Fernández, S. Serén Trasorras, C. Vilas Iglesias, M. Zavadska, D. Balode, A. Bārzdiņa, A. Deksne, D. Gardovska, D. Grāvele, D. Grope, I. Meiere, A. Nokalna, I. Pavāre, J. Pučuka, Z. Selecka, K. Sidorova, A. Svile, D. Urbāne, U.N. Usuf, E. Bojang, K. Zaman, S.M.A. Secka, F. Anderson, S. Roca, A. Sarr, I. Saidykhan, M. Darboe, S. Ceesay, S. D’alessandro, U. Moll, H.A. Borensztajn, D.M. Hagedoorn, N.N. Tan, C. Vermont, C.L. Zachariasse, J. Dik, W. Agyeman, P. Schlapbach, L.J. Aebi, C. Wyss, V. Usman, M. Agyeman, P. Schlapbach, L.J. Giannoni, E. Stocker, M. Posfay-Barbe, K.M. Heininger, U. Bernhard-Stirnemann, S. Niederer-Loher, A. Kahlert, C. Natalucci, G. Relly, C. Riedel, T. Aebi, C. Berger, C. Carrol, E.D. Paulus

Abstract

Febrile children below 3 months have a higher risk of serious bacterial infections, which often leads to extensive diagnostics and treatment. There is practice variation in management due to differences in guidelines and their usage and adherence. We aimed to assess whether management in febrile children below 3 months attending European Emergency Departments (EDs) was according to the guidelines for fever. This study is part of the MOFICHE study, which is an observational multicenter study including routine data of febrile children (0–18 years) attending twelve EDs in eight European countries. In febrile children below 3 months (excluding bronchiolitis), we analyzed actual management compared to the guidelines for fever. Ten EDs applied the (adapted) NICE guideline, and two EDs applied local guidelines. Management included diagnostic tests, antibiotic treatment, and admission. We included 913 children with a median age of 1.7 months (IQR 1.0–2.3). Management per ED varied as follows: use of diagnostic tests 14–83%, antibiotic treatment 23–54%, admission 34–86%. Adherence to the guideline was 43% (374/868) for blood cultures, 29% (144/491) for lumbar punctures, 55% (270/492) for antibiotic prescriptions, and 67% (573/859) for admission. Full adherence to these four management components occurred in 15% (132/868, range 0–38%), partial adherence occurred in 56% (484/868, range 35–77%). Conclusion: There is large practice variation in management. The guideline adherence was limited, but highest for admission which implies a cautious approach. Future studies should focus on guideline revision including new biomarkers in order to optimize management in young febrile children.What is Known:• Febrile children below 3 months have a higher risk of serious bacterial infections, which often leads to extensive diagnostics and treatment.• There is practice variation in management of young febrile children due to differences in guidelines and their usage and adherence.What is New

Published
2022

23. Nachbehandlungsempfehlungen 2022 Arbeitskreis Nachbehandlungsempfehlungen Sektion Physikalische Therapie und Rehabilitation der DGOU

Author

Schmidt, Jörg, Riedel, Tobias, Grundler, Stefan, Belzl, Harry, Detzel, Dagmar, Ernst, Ulrich, Gahr, Patrick, Heining, Sandro, Held, Jeremia, Janssen, Larissa, Petzold, Ronny, Rädlein, Andrea, Ridder, Eva, Simmel, Stefan, Schmidt, J ( Jörg ), Riedel, T ( Tobias ), Grundler, S ( Stefan ), Belzl, H ( Harry ), Detzel, D ( Dagmar ), Ernst, U ( Ulrich ), Gahr, P ( Patrick ), Heining, S ( Sandro ), Held, J ( Jeremia ), Janssen, L ( Larissa ), Petzold, R ( Ronny ), Rädlein, A ( Andrea ), Ridder, E ( Eva ), Simmel, S ( Stefan ), Schmidt, Jörg, Riedel, Tobias, Grundler, Stefan, Belzl, Harry, Detzel, Dagmar, Ernst, Ulrich, Gahr, Patrick, Heining, Sandro, Held, Jeremia, Janssen, Larissa, Petzold, Ronny, Rädlein, Andrea, Ridder, Eva, Simmel, Stefan, Schmidt, J ( Jörg ), Riedel, T ( Tobias ), Grundler, S ( Stefan ), Belzl, H ( Harry ), Detzel, D ( Dagmar ), Ernst, U ( Ulrich ), Gahr, P ( Patrick ), Heining, S ( Sandro ), Held, J ( Jeremia ), Janssen, L ( Larissa ), Petzold, R ( Ronny ), Rädlein, A ( Andrea ), Ridder, E ( Eva ), and Simmel, S ( Stefan )

Published
2022

25. RACE IT - A prospective, single arm, multicenter, phase II-trial to assess safety and efficacy of preoperative RAdiation therapy before radical CystEctomy combined with ImmunoTherapy in locally advanced urothelial carcinoma of the bladder (AB 65/18)

Author

Schmid, S.C., primary, Schiller, K., additional, Seitz, A.K., additional, Koll, F.J., additional, Beckert, F., additional, Korn, P., additional, Lewerich, J., additional, Maisch, P., additional, Sauter, A., additional, Rödel, C., additional, Flentje, M., additional, Riedel, T., additional, Combs, S., additional, Zengerling, F., additional, Bolenz, C., additional, Kübler, H., additional, Gschwend, J.E., additional, and Retz, M., additional

Published
2022
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27. Towards high-capacity HTS flywheel systems

Author

Werfel, F.N., Floegel-Delor, U., Riedel, T., Rothfeld, R., Wippich, D., Goebel, B., Reiner, G., and Wehlau, N.

Subjects
Flywheels -- Design and construction, Flywheels -- Energy use, High temperature superconductors -- Usage, Rotors -- Design and construction, Business, Electronics, Electronics and electrical industries
Published
2010

28. HTS magnetic bearings in prototype application

Author

Werfel, F.N., Floegel-Delor, U., Riedel, T., Rothfeld, R., Wippich, D., and Goebel, B.

Subjects
Cryostat -- Usage, Flywheels -- Design and construction, High temperature superconductors -- Usage, Magnetic bearings -- Design and construction, Magnetic suspension -- Analysis, Business, Electronics, Electronics and electrical industries
Published
2010

31. Nozzle geometry and injection duration effects on diesel sprays measured by x-ray radiography

Author

Kastengren, A.L., Powell, C.F., Riedel, T., Cheong, S.-K., Im, K.-S., Liu, X., Wang, Y.J., and Wang, J.

Subjects
Radiography -- Methods, Spray nozzles -- Design and construction, Spray nozzles -- Mechanical properties, Fluid dynamics -- Research, Injectors -- Design and construction, Injectors -- Mechanical properties, Engineering and manufacturing industries, Science and technology
Abstract

X-ray radiography was used to measure the behavior of four fuel sprays from a light-duty common-rail diesel injector. The sprays were at 250 bar injection pressure and 1 bar ambient pressure. Injection durations of 400 [micro]s and 1000 [micro]s were tested, as were axial single-hole nozzles with hydroground and nonhydroground geometries. The X-ray data provide quantitative measurements of the internal mass distribution of the spray, including near the injector orifice. Such measurements are not possible with optical diagnostics. The 400 [micro]s sprays from the hydroground and nonhydroground nozzles appear qualitatively similar. The 1000 [micro]s spray from the nonhydroground nozzle has a relatively consistent moderate width, while that from the hydroground nozzle is quite wide before transitioning into a narrow jet. The positions of the leading- and trailing-edges of the spray have also been determined, as has the amount of fuel residing in a concentrated structure near the leading edge of the spray. [DOI: 10.111511.2903516]

Published
2008

32. 1293MO Safety and efficacy of hypo- and conventionally fractionated thoracic radiotherapy plus durvalumab in elderly or frail NSCLC stage III patients unfit for chemotherapy: Interim results from the TRADE-hypo trial

Author

Bozorgmehr, F., Buchmeier, E.L., Hammer-Hellmig, M., Nestle, U., Meyer zum Bueschenfelde, C., Weykamp, F., Classen, J., Schuett, P., Riedel, T., Wehler, T., Hey-Koch, S., Overbeck, T.R., Alt, J., Schmidberger, H., Behnisch, R., Chung, I., Thomas, M., and Rieken, S.

Published
2023
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36. P0500 / #2092: CHRONIC CRITICAL ILLNESS IN PEDIATRIC INTENSIVE CARE (OCTOPUS STUDY): PICU RESOURCE USE AND NURSING WORKLOAD

Author

Grandjean, C., primary, Perez, M.-H., additional, Fazan, M.-C., additional, Rio, L., additional, Trachsel, D., additional, Marston, M., additional, Humpl, T., additional, Schnidrig, S., additional, Polito, A., additional, Bochaton, N., additional, Riedel, T., additional, Van Kleef, P., additional, Neuhaus, T., additional, Stalder, S., additional, Rodgo, B., additional, Wild, E., additional, Brotschi, B., additional, Frey, B., additional, Schlüer, B., additional, Von Arx, F., additional, and Ramelet, A.-S., additional

Published
2021
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37. P0469 / #762: CHRONIC CRITICAL ILLNESS IN PEDIATRIC INTENSIVE CARE IN SWITZERLAND (OCTOPUS): CHILDREN’ CARE CHARACTERISTICS AND NURSING WORKLOAD

Author

Grandjean, C., primary, Perez, M.-H., additional, Fazan, M.-C., additional, Rio, L., additional, Lauria, A.-L., additional, Trachsel, D., additional, Marston, M., additional, Humpl, T., additional, Schnidrig, S., additional, Polito, A., additional, Bochaton, N., additional, Riedel, T., additional, Van Kleef, P., additional, Neuhaus, T., additional, Stalder, S., additional, Rodgo, B., additional, Wild, E., additional, Frey, B., additional, Schlüer, B., additional, Von Arx, F., additional, and Ramelet, A.-S., additional

Published
2021
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38. DEGRO 2004: 10. Jahreskongress der Deutschen Gesellschaft für Radioonkologie

Author

Wendt, Thomas G., Gademann, G., Pambor, C., Grießbach, I., von Specht, H., Martin, T., Baltas, D., Kurek, R., Röddiger, S., Tunn, U. W., Zamboglou, N., Eich, H. T., Staar, S., Gossmann, A., Hansemann, K., Semrau, R., Skripnitchenko, R., Diehl, V., Müller, R.-P., Sehlen, S., Willich, N., Rühl, U., Lukas, P., Dühmke, E., Engel, K., Tabbert, E., Bolck, M., Knaack, S., Annweiler, H., Krempien, R., Hoppe, H., Harms, W., Daeuber, S., Schorr, O., Treiber, M., Debus, J., Alber, M., Paulsen, F., Birkner, M., Bakai, A., Belka, C., Budach, W., Grosser, K.-H., Kramer, R., Kober, B., Reinert, M., Schneider, P., Hertel, A., Feldmann, H., Csere, P., Hoinkis, C., Rothe, G., Zahn, P., Alheit, H., Cavanaugh, S. X., Kupelian, P., Reddy, C., Pollock, B., Fuss, M., Roeddiger, S., Dannenberg, T., Rogge, B., Drechsler, D., Herrmann, T., Alberti, W., Schwarz, R., Graefen, M., Krüll, A., Rudat, V., Huland, H., Fehr, C., Baum, C., Glocker, S., Nüsslin, F., Heil, T., Lemnitzer, H., Knips, M., Baumgart, O., Thiem, W., Kloetzer, K.-H., Hoffmann, L., Neu, B., Hültenschmidt, B., Sautter-Bihl, M.-L., Micke, O., Seegenschmiedt, M. H., Köppen, D., Klautke, G., Fietkau, R., Schultze, J., Schlichting, G., Koltze, H., Kimmig, B., Glatzel, M., Fröhlich, D., Bäsecke, S., Krauß, A., Strauß, D., Buth, K.-J., Böhme, R., Oehler, W., Bottke, D., Keilholz, U., Heufelder, K., Wiegel, T., Hinkelbein, W., Rödel, C., Papadopoulos, T., Munnes, M., Wirtz, R., Sauer, R., Rödel, F., Lubgan, D., Distel, L., Grabenbauer, G. G., Sak, A., Stüben, G., Pöttgen, C., Grehl, S., Stuschke, M., Müller, K., Pfaffendorf, C., Mayerhofer, A., Köhn, F. M., Ring, J., van Beuningen, D., Meineke, V., Neubauer, S., Keller, U., Wittlinger, M., Riesenbeck, D., Greve, B., Exeler, R., Ibrahim, M., Liebscher, C., Severin, E., Ott, O., Pötter, R., Hammer, J., Hildebrandt, G., Beckmann, M. W., Strnad, V., Fehlauer, F., Tribius, S., Bajrovic, A., Höller, U., Rades, D., Warszawski, A., Baumann, R., Madry-Gevecke, B., Karstens, J. H., Grehn, C., Hensley, F., Berns, C., Wannenmacher, M., Semrau, S., Reimer, T., Gerber, B., Ketterer, P., Koepcke, E., Hänsgen, G., Strauß, H. G., Dunst, J., Füller, J., Kalb, S., Wendt, T., Weitmann, H. D., Waldhäusl, C., Knocke, T.-H., Lamprecht, U., Classen, J., Kaulich, T. W., Aydeniz, B., Bamberg, M., Wiezorek, T., Banz, N., Salz, H., Scheithauer, M., Schwedas, M., Lutterbach, J., Bartelt, S., Frommhold, H., Lambert, J., Hornung, D., Swiderski, S., Walke, M., Siefert, A., Pöllinger, B., Krimmel, K., Schaffer, M., Koelbl, O., Bratengeier, K., Vordermark, D., Flentje, M., Hero, B., Berthold, F., Combs, S. E., Gutwein, S., Schulz-Ertner, D., van Kampen, M., Thilmann, C., Kocher, M., Kunze, S., Schild, S., Ikezaki, K., Müller, B., Sieber, R., Weiß, C., Wolf, I., Wenz, F., Weber, K.-J., Schäfer, J., Engling, A., Laufs, S., Veldwijk, M. R., Milanovic, D., Fleckenstein, K., Zeller, W., Fruehauf, S., Herskind, C., Weinmann, M., Jendrossek, V., Rübe, C., Appold, S., Kusche, S., Hölscher, T., Brüchner, K., Geyer, P., Baumann, M., Kumpf, R., Zimmermann, F., Schill, S., Geinitz, H., Nieder, C., Jeremic, B., Molls, M., Liesenfeld, S., Petrat, H., Hesselmann, S., Schäfer, U., Bruns, F., Horst, E., Wilkowski, R., Assmann, G., Nolte, A., Diebold, J., Löhrs, U., Fritz, P., Hans-Jürgen, K., Mühlnickel, W., Bach, P., Wahlers, B., Kraus, H.-J., Wulf, J., Hädinger, U., Baier, K., Krieger, T., Müller, G., Hof, H., Herfarth, K., Brunner, T., Hahn, S. M., Schreiber, F. S., Rustgi, A. K., McKenna, W. G., Bernhard, E. J., Guckenberger, M., Meyer, K., Willner, J., Schmidt, M., Kolb, M., Li, M., Gong, P., Abdollahi, A., Trinh, T., Huber, P. E., Christiansen, H., Saile, B., Neubauer-Saile, K., Tippelt, S., Rave-Fränk, M., Hermann, R. M., Dudas, J., Hess, C. F., Schmidberger, H., Ramadori, G., Andratschke, N., Price, R., Ang, K.-K., Schwarz, S., Kulka, U., Busch, M., Schlenger, L., Bohsung, J., Eichwurzel, I., Matnjani, G., Sandrock, D., Richter, M., Wurm, R., Budach, V., Feussner, A., Gellermann, J., Jordan, A., Scholz, R., Gneveckow, U., Maier-Hauff, K., Ullrich, R., Wust, P., Felix, R., Waldöfner, N., Seebass, M., Ochel, H.-J., Dani, A., Varkonyi, A., Osvath, M., Szasz, A., Messer, P. M., Blumstein, N. M., Gottfried, H.-W., Schneider, E., Reske, S. N., Röttinger, E. M., Grosu, A.-L., Franz, M., Stärk, S., Weber, W., Heintz, M., Indenkämpen, F., Beyer, T., Lübcke, W., Levegrün, S., Hayen, J., Czech, N., Mbarek, B., Köster, R., Thurmann, H., Todorovic, M., Schuchert, A., Meinertz, T., Münzel, T., Grundtke, H., Hornig, B., Hehr, T., Dilcher, C., Chan, R. C., Mintz, G. S., Kotani, J.-I., Shah, V. M., Canos, D. A., Weissman, N. J., Waksman, R., Wolfram, R., Bürger, B., Schrappe, M., Timmermann, B., Lomax, A., Goitein, G., Schuck, A., Mattke, A., Int-Veen, C., Brecht, I., Bernhard, S., Treuner, J., Koscielniak, E., Heinze, F., Kuhlen, M., von Schorlemer, I., Ahrens, S., Hunold, A., Könemann, S., Winkelmann, W., Jürgens, H., Gerstein, J., Polivka, B., Sykora, K.-W., Bremer, M., Thamm, R., Höpfner, C., Gumprecht, H., Jäger, R., Leonardi, M. A., Frank, A. M., Trappe, A. E., Lumenta, C. B., Östreicher, E., Pinsker, K., Müller, A., Fauser, C., Arnold, W., Henzel, M., Groß, M. W., Engenhart-Cabillic, R., Schüller, P., Palkovic, S., Schröder, J., Wassmann, H., Block, A., Bauer, R., Keffel, F.-W., Theophil, B., Wisser, L., Rogger, M., Niewald, M., van Lengen, V., Mathias, K., Welzel, G., Bohrer, M., Steinvorth, S., Schleußner, C., Leppert, K., Röhrig, B., Strauß, B., van Oorschot, B., Köhler, N., Anselm, R., Winzer, A., Schneider, T., Koch, U., Schönekaes, K., Mücke, R., Büntzel, J., Kisters, K., Scholz, C., Keller, M., Winkler, C., Prause, N., Busch, R., Roth, S., Haas, I., Willers, R., Schultze-Mosgau, S., Wiltfang, J., Kessler, P., Neukam, F. W., Röper, B., Nüse, N., Auer, F., Melzner, W., Geiger, M., Lotter, M., Kuhnt, T., Müller, A. C., Jirsak, N., Gernhardt, C., Schaller, H.-G., Al-Nawas, B., Klein, M. O., Ludwig, C., Körholz, J., Grötz, K. A., Huppers, K., Kunkel, M., Olschewski, T., Bajor, K., Lang, B., Lang, E., Kraus-Tiefenbacher, U., Hofheinz, R., von Gerstenberg-Helldorf, B., Willeke, F., Hochhaus, A., Roebel, M., Oertel, S., Riedl, S., Buechler, M., Foitzik, T., Ludwig, K., Klar, E., Meyer, A., Meier zu Eissen, J., Schwab, D., Meyer, T., Höcht, S., Siegmann, A., Sieker, F., Pigorsch, S., Milicic, B., Acimovic, L., Milisavljevic, S., Radosavljevic-Asic, G., Presselt, N., Baum, R. P., Treutler, D., Bonnet, R., Schmücking, M., Sammour, D., Fink, T., Ficker, J., Pradier, O., Lederer, K., Weiss, E., Hille, A., Welz, S., Sepe, S., Friedel, G., Spengler, W., Susanne, E., Kölbl, O., Hoffmann, W., Wörmann, B., Günther, A., Becker-Schiebe, M., Güttler, J., Schul, C., Nitsche, M., Körner, M. K., Oppenkowski, R., Guntrum, F., Malaimare, L., Raub, M., Schöfl, C., Averbeck, T., Hacker, I., Blank, H., Böhme, C., Imhoff, D., Eberlein, K., Weidauer, S., Böttcher, H. D., Edler, L., Tatagiba, M., Molina, H., Ostertag, C., Milker-Zabel, S., Zabel, A., Schlegel, W., Hartmann, A., Wildfang, I., Kleinert, G., Hamm, K., Reuschel, W., Wehrmann, R., Kneschaurek, P., Münter, M. W., Nikoghosyan, A., Didinger, B., Nill, S., Rhein, B., Küstner, D., Schalldach, U., Eßer, D., Göbel, H., Wördehoff, H., Pachmann, S., Hollenhorst, H., Dederer, K., Evers, C., Lamprecht, J., Dastbaz, A., Schick, B., Fleckenstein, J., Plinkert, P. K., Rübe, Chr., Merz, T., Sommer, B., Mencl, A., Ghilescu, V., Astner, S., Martin, A., Momm, F., Volegova-Neher, N. J., Schulte-Mönting, J., Guttenberger, R., Buchali, A., Blank, E., Sidow, D., Huhnt, W., Gorbatov, T., Heinecke, A., Beckmann, G., Bentia, A.-M., Schmitz, H., Spahn, U., Heyl, V., Prott, P.-J., Galalae, R., Schneider, R., Voith, C., Scheda, A., Hermann, B., Bauer, L., Melchert, F., Kröger, N., Grüneisen, A., Jänicke, F., Zander, A., Zuna, I., Schlöcker, I., Wagner, K., John, E., Dörk, T., Lochhas, G., Houf, M., Lorenz, D., Link, K.-H., Prott, F.-J., Thoma, M., Schauer, R., Heinemann, V., Romano, M., Reiner, M., Quanz, A., Oppitz, U., Bahrehmand, R., Tine, M., Naszaly, A., Patonay, P., Mayer, Á., Markert, K., Mai, S.-K., Lohr, F., Dobler, B., Pinkawa, M., Fischedick, K., Treusacher, P., Cengiz, D., Mager, R., Borchers, H., Jakse, G., Eble, M. J., Asadpour, B., Krenkel, B., Holy, R., Kaplan, Y., Block, T., Czempiel, H., Haverkamp, U., Prümer, B., Christian, T., Benkel, P., Weber, C., Gruber, S., Reimann, P., Blumberg, J., Krause, K., Fischedick, A.-R., Kaube, K., Steckler, K., Henzel, B., Licht, N., Loch, T., Krystek, A., Lilienthal, A., Alfia, H., Claßen, J., Spillner, P., Knutzen, B., Souchon, R., Schulz, I., Grüschow, K., Küchenmeister, U., Vogel, H., Wolff, D., Ramm, U., Licner, J., Rudolf, F., Moog, J., Rahl, C. G., Mose, S., Vorwerk, H., Weiß, E., Engert, A., Seufert, I., Schwab, F., Dahlke, J., Zabelina, T., Krüger, W., Kabisch, H., Platz, V., Wolf, J., Pfistner, B., Stieltjes, B., Wilhelm, T., Schmuecking, M., Junker, K., Treutier, D., Schneider, C. P., Leonhardi, J., Niesen, A., Hoeffken, K., Schmidt, A., Mueller, K.-M., Schmid, I., Lehmann, K., Blumstein, C. G., Kreienberg, R., Freudenberg, L., Kühl, H., Stahl, M., Elo, B., Erichsen, P., Stattaus, H., Welzel, T., Mende, U., Heiland, S., Salter, B. J., Schmid, R., Stratakis, D., Huber, R. M., Haferanke, J., Zöller, N., Henke, M., Lorenzen, J., Grzyska, B., Kuhlmey, A., Adam, G., Hamelmann, V., Bölling, T., Job, H., Panke, J. E., Feyer, P., Püttmann, S., Siekmeyer, B., Jung, H., Gagel, B., Militz, U., Piroth, M., Schmachtenberg, A., Hoelscher, T., Verfaillie, C., Kaminski, B., Lücke, E., Mörtel, H., Eyrich, W., Fritsch, M., Georgi, J.-C., Plathow, C., Zieher, H., Kiessling, F., Peschke, P., Kauczor, H.-U., Licher, J., Schneider, O., Henschler, R., Seidel, C., Kolkmeyer, A., Nguyen, T. P., Janke, K., Michaelis, M., Bischof, M., Stoffregen, C., Lipson, K., Weber, K., Ehemann, V., Jürgen, D., Achanta, P., Thompson, K., Martinez, J. L., Körschgen, T., Pakala, R., Pinnow, E., Hellinga, D., O’Tio, F., Katzer, A., Kaffer, A., Kuechler, A., Steinkirchner, S., Dettmar, N., Cordes, N., Frick, S., Kappler, M., Taubert, H., Bartel, F., Schmidt, H., Bache, M., Frühauf, S., Wenk, T., Litzenberger, K., Erren, M., van Valen, F., Liu, L., Yang, K., Palm, J., Püsken, M., Behe, M., Behr, T. M., Marini, P., Johne, A., Claussen, U., Liehr, T., Steil, V., Moustakis, C., Griessbach, I., Oettel, A., Schaal, C., Reinhold, M., Strasssmann, G., Braun, I., Vacha, P., Richter, D., Osterham, T., Wolf, P., Guenther, G., Miemietz, M., Lazaridis, E. A., Forthuber, B., Sure, M., Klein, J., Saleske, H., Riedel, T., Hirnle, P., Horstmann, G., Schoepgens, H., Van Eck, A., Bundschuh, O., Van Oosterhut, A., Xydis, K., Theodorou, K., Kappas, C., Zurheide, J., Fridtjof, N., Ganswindt, U., Weidner, N., Buchgeister, M., Weigel, B., Müller, S. B., Glashörster, M., Weining, C., Hentschel, B., Sauer, O. A., Kleen, W., Beck, J., Lehmann, D., Ley, S., Fink, C., Puderbach, M., Hosch, W., Schmähl, A., Jung, K., Stoßberg, A., Rolf, E., Damrau, M., Oetzel, D., Maurer, U., Maurer, G., Lang, K., Zumbe, J., Hahm, D., Fees, H., Robrandt, B., Melcher, U., Niemeyer, M., Mondry, A., Kanellopoulos-Niemeyer, V., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Schiebe, M., Pinkert, U., Piasswilm, L., Pohl, F., Garbe, S., Wolf, K., Nour, Y., Barwig, P., Trog, D., Schäfer, C., Herbst, M., Dietl, B., Cartes, M., Schroeder, F., Sigingan-Tek, G., Feierabend, R., Theden, S., Schlieck, A., Gotthardt, M., Glowalla, U., Kremp, S., Hamid, O., Riefenstahl, N., Michaelis, B., Schaal, G., Liebermeister, E., Niewöhner-Desbordes, U., Kowalski, M., Franz, N., Stahl, W., Baumbach, C., Thale, J., Wagner, W., Justus, B., Huston, A. L., Seaborn, R., Rai, P., Rha, S.-W., Sakas, G., Wesarg, S., Zogal, P., Schwald, B., Seibert, H., Berndt-Skorka, R., Seifert, G., Schoenekaes, K., Bilecen, C., Ito, W., Matschuck, G., and Isik, D.

Published
2004
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40. Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants

Author

van Kaam, Anton H, De Jaegere, Anne P, Rimensberger, Peter C, Debeer, A., Chemin, A., Norbert, K., Autret, F., Andreou, A., Kroon, A., Minić, A., Schwindt, J., Brouwers, H., van Reempts, P., Hummler, H., van Veenendaal, M., Sarafidis, K., Lopriore, E., Mosca, F., McCormick, K., Schaible, T., Jaarsma, A., Polimeni, V., Plavka, R., Patkai, J., Moriette, G., Valls, A., Soler, I., Clarke, P., Migliori, C., Hentschel, R., Sigalas, J., Ehlen, M., Fremerey, C., Roujou-Gris, M., Stamatin, M., Mok, Q., Ata, S., Günther, M., Kühr, J., Seitz, U., Vermeulen, M., Knol, R., Le Bouedec, S., Szekessy, D., Wauer, R., Petropoulou, C., Moreno Hernando, J., Jonsson, B., Mulder, T., Sweet, D., Herting, E., Goepel, W., Dimitriou, G., Stuchlíková, H., Baltogianni, M., Santillo, V., Ferrero, F., Arnault, I., Dort, J., Blanc, T., Rocha, G., Guimarães, H., Virella, D., Costa, A., Pedro Frutuoso, S., Biolek, J., Stoicescu, S., Schroth, M., Cirstoveanu, C., de Boode, W., Medbo, S., Müller-Hansen, I., Poets, C., Riedel, T., Palmer, K., Martano, C., Stucin Gantar, I., Biban, P., Chatfield, S., Ghesquiere, J., Theret, B., Samperiz, S., Berger, T., Rigo, V., Balato, A., Gresa Munoz, M., Nunes, A., Molendijk, H., Beuger, S., Puzas, A., Hiedl, S., Genzel-Boroviczeny, O., Anhalt, D., Möller, J., Ingemansson, F., Halbertsma, F., de Cesaris, V., Saarela, T., Karagianni, P., Tsakalidis, C., Tølløfsrud, P., Bougatef, A., Sindelar, R., Wisborg, K., Brink Henriksen, T., Flumini, C., Carnielli, V., Giannuzzo, S., Dussart, A., Brault, D., Samy, M., van Wien, A., Cunha, M., Paulino, E., Schneider, H., Sandvoss, A., Dahlem, P., Koester, B., Olhanger, E., Wentzell, R., Ramos, C., Augusta Areias, M., Verber, I., Presta, G., Magaldi, R., Agostino, R., Lund, O., Ulriksen, J., Steder, U., Faas, D., Jensen, R., Baroutis, G., Gouder de Beauregard, V., Zaharie, G., Eng-Schwartz, A., Heldmann, M., Cezanne, T., Pereira, A., Nelle, M., Uxa, F., Norman, M., Siegel, J., Welsch, M., Schiffmann, H., Haftel, L., Wild, F., Bühr, P., Simma, B., Thirumurugan, A., Mortensen, S., Ciccotti, R., Carli, G., Milligan, D., Gerleve, H., Kumararatne, B., Hakansson, S., OʼDonovan, D., Reiterer, F., Rimensberger, P., Nietsch, L., Nakstad, B., Gancia, P., Swanstrom, S., Maton, P., Cavatorta, E., Tvarijonoviciene, R., Hogan, M., Zinn, P., Freff, M., Reigstad, H., Olariu, G., Gonçalves, G., Escumalha, M., Ornelas, H., Serrano, A., Anderssen, S., Garcia, P., Mendes Da Graça, A., Bender, C., Wald, M., Bohn, M., Schnelke, A., Trips, T., Ladekjaer, J., Thompson, F., Lindberg, E., Frigerio, M., Pederzini, F., De Nisi, G., Saur, G., Losa, M., Toma, A., Matu, E., Eckhardt, S., Bellettato, M., Fahnenstich, H., Hetzel, P., Bland, J., Øglænd, B., Lehtonen, L., Eichler, T., Roth, M., Meberg, A., Kuehn, T., and Emeis, M.

Published
2013
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41. Progress toward 500 kg HTS bearings

Author

Werfel, F.N., Floegel-Delor, U., Riedel, T., Rothfeld, R., Wippich, D., Goebel, B., Kummeth, P., Neumueller, H.W., and Nick, W.

Subjects
Superconductors -- Research, Superconductive devices -- Research, Magnetic bearings -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Research involving HTS radial bearings is described. The bearings are for use in motors, generators and flywheels.

Published
2003

42. Current transport and FCL properties of polycrystalline melt textured YBCO

Author

Floegel-Delor, U., Riedel, T., Rothfeld, R., Wippich, D., Goebel, B., and Werfel, F.N.

Subjects
Superconductive devices -- Research, Superconductors -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Current transport and fault current limiter (FCL) properties of polycrystalline melt textured YBCO devices are examined and discussed.

Published
2003

47. Implicit Middleware

Author

Riedel, T., primary, Beigl, M., additional, Berchtold, M., additional, Decker, C., additional, and Puder, A., additional

Published
2008
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