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3,799 results on '"Riedel‐Heller, Steffi"'

1. A meta-analysis of genome-wide studies of resilience in the German population

Author

Herrera-Rivero, Marisol, Garvert, Linda, Horn, Katrin, Löbner, Margrit, Weitzel, Elena Caroline, Stoll, Monika, Lichtner, Peter, Teismann, Henning, Teumer, Alexander, Van der Auwera, Sandra, Völzke, Henry, Völker, Uwe, Andlauer, Till F. M., Meinert, Susanne, Heilmann-Heimbach, Stefanie, Forstner, Andreas J., Streit, Fabian, Witt, Stephanie H., Kircher, Tilo, Dannlowski, Udo, Scholz, Markus, Riedel-Heller, Steffi G., Grabe, Hans J., Baune, Bernhard T., and Berger, Klaus

Published
2025
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4. Selbsthilfeangebote für Menschen mit schwerer psychischer Erkrankung – wer nutzt welches Format?

Author

Richter, Daniel, Breilmann, Johanna, Becker, Thomas, Allgöwer, Andreas, Kilian, Reinhold, Hasan, Alkomiet, Falkai, Peter, Ajayi, Klemens, Halms, Theresa, Brieger, Peter, Frasch, Karel, Heres, Stephan, Jäger, Markus, Küthmann, Andreas, Putzhammer, Albert, Riedel-Heller, Steffi G., Schneeweiß, Bertram, Schwarz, Michael, Kösters, Markus, and Gühne, Uta

Published
2025
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7. Evidence Synthesis of Digital Interventions to Mitigate the Negative Impact of the COVID-19 Pandemic on Public Mental Health: Rapid Meta-review

Author

Rauschenberg, Christian, Schick, Anita, Hirjak, Dusan, Seidler, Andreas, Paetzold, Isabell, Apfelbacher, Christian, Riedel-Heller, Steffi G, and Reininghaus, Ulrich

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundAccumulating evidence suggests the COVID-19 pandemic has negative effects on public mental health. Digital interventions that have been developed and evaluated in recent years may be used to mitigate the negative consequences of the pandemic. However, evidence-based recommendations on the use of existing telemedicine and internet-based (eHealth) and app-based mobile health (mHealth) interventions are lacking. ObjectiveThe aim of this study was to investigate the theoretical and empirical base, user perspective, safety, effectiveness, and cost-effectiveness of digital interventions related to public mental health provision (ie, mental health promotion, prevention, and treatment of mental disorders) that may help to reduce the consequences of the COVID-19 pandemic. MethodsA rapid meta-review was conducted. The MEDLINE, PsycINFO, and CENTRAL databases were searched on May 11, 2020. Study inclusion criteria were broad and considered systematic reviews and meta-analyses that investigated digital tools for health promotion, prevention, or treatment of mental health conditions and determinants likely affected by the COVID-19 pandemic. ResultsOverall, 815 peer-reviewed systematic reviews and meta-analyses were identified, of which 83 met the inclusion criteria. Our findings suggest that there is good evidence on the usability, safety, acceptance/satisfaction, and effectiveness of eHealth interventions. Evidence on mHealth apps is promising, especially if social components (eg, blended care) and strategies to promote adherence are incorporated. Although most digital interventions focus on the prevention or treatment of mental disorders, there is some evidence on mental health promotion. However, evidence on process quality, cost-effectiveness, and long-term effects is very limited. ConclusionsThere is evidence that digital interventions are particularly suited to mitigating psychosocial consequences at the population level. In times of physical distancing, quarantine, and restrictions on social contacts, decision makers should develop digital strategies for continued mental health care and invest time and efforts in the development and implementation of mental health promotion and prevention programs.

Published
2021
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8. Internet Use in Old Age: Results of a German Population-Representative Survey

Author

Quittschalle, Janine, Stein, Janine, Luppa, Melanie, Pabst, Alexander, Löbner, Margrit, Koenig, Hans-Helmut, and Riedel-Heller, Steffi G

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundThe internet has the potential to foster healthy lifestyles and to support chronic disease management. Older adults could benefit from using the internet and other information and communication technology to access health-related information and interventions available online. ObjectiveThe aim of this study was to investigate factors influencing internet use in older and oldest age groups and to determine the frequency of internet use for health-related purposes. MethodsUsing data from a nationally representative telephone survey of older adults aged 75 years and over, a sample of 999 people was assessed using structured clinical interviews. Descriptive and binary logistic regression analyses were performed. ResultsOverall, 42.6% (418/999) of participants used the internet. Among those, 55.7% (233/417) searched the internet for health-related information. Regression analyses revealed that internet use was significantly associated with younger age (odds ratio [OR] 0.89, 95% CI 0.85-0.92; P

Published
2020
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10. X‐chromosome-wide association study for Alzheimer’s disease

Author

Le Borgne, Julie, Gomez, Lissette, Heikkinen, Sami, Amin, Najaf, Ahmad, Shahzad, Choi, Seung Hoan, Bis, Joshua, Grenier-Boley, Benjamin, Rodriguez, Omar Garcia, Kleineidam, Luca, Young, Juan, Tripathi, Kumar Parijat, Wang, Lily, Varma, Achintya, Campos-Martin, Rafael, van der Lee, Sven, Damotte, Vincent, de Rojas, Itziar, Palmal, Sagnik, Lipton, Richard, Reiman, Eric, McKee, Ann, De Jager, Philip, Bush, William, Small, Scott, Levey, Allan, Saykin, Andrew, Foroud, Tatiana, Albert, Marilyn, Hyman, Bradley, Petersen, Ronald, Younkin, Steven, Sano, Mary, Wisniewski, Thomas, Vassar, Robert, Schneider, Julie, Henderson, Victor, Roberson, Erik, DeCarli, Charles, LaFerla, Frank, Brewer, James, Swerdlow, Russell, Van Eldik, Linda, Hamilton-Nelson, Kara, Paulson, Henry, Naj, Adam, Lopez, Oscar, Chui, Helena, Crane, Paul, Grabowski, Thomas, Kukull, Walter, Asthana, Sanjay, Craft, Suzanne, Strittmatter, Stephen, Cruchaga, Carlos, Leverenz, James, Goate, Alison, Kamboh, M. Ilyas, George-Hyslop, Peter St, Valladares, Otto, Kuzma, Amanda, Cantwell, Laura, Riemenschneider, Matthias, Morris, John, Slifer, Susan, Dalmasso, Carolina, Castillo, Atahualpa, Küçükali, Fahri, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Deckert, Jürgen, Riedel-Heller, Steffi, Hausner, Lucrezia, Molina-Porcel, Laura, Düzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Dols-Icardo, Oriol, Moreno, Fermin, Pérez-Tur, Jordi, Bullido, María J., Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis M., Piñol-Ripoll, Gerard, García-Alberca, Jose María, Royo, Jose Luís, Rodriguez-Rodriguez, Eloy, Soininen, Hilkka, de Mendonça, Alexandre, Mehrabian, Shima, Traykov, Latchezar, Hort, Jakub, Vyhnalek, Martin, Thomassen, Jesper Qvist, Pijnenburg, Yolande A. L., Holstege, Henne, van Swieten, John, Ramakers, Inez, Verhey, Frans, Scheltens, Philip, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Deleuze, Jean-François, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stéphanie, Grünblatt, Edna, Popp, Julius, Ghidoni, Roberta, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Spallazzi, Marco, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Bossù, Paola, Masullo, Carlo, Rossi, Giacomina, Jessen, Frank, Fernandez, Victoria, Kehoe, Patrick Gavin, Frikke-Schmidt, Ruth, Tsolaki, Magda, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Haines, Jonathan, Farrer, Lindsay, Mayeux, Richard, Wang, Li-San, Sims, Rebecca, DeStefano, Anita, Schellenberg, Gerard D., Seshadri, Sudha, Amouyel, Philippe, Williams, Julie, van der Flier, Wiesje, Ramirez, Alfredo, Pericak-Vance, Margaret, Andreassen, Ole A., Van Duijn, Cornelia, Hiltunen, Mikko, Ruiz, Agustín, Dupuis, Josée, Martin, Eden, Lambert, Jean-Charles, Kunkle, Brian, and Bellenguez, Céline

Published
2024
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11. An Investigation into the Relationship of Circulating Gut Microbiome Molecules and Inflammatory Markers with the Risk of Incident Dementia in Later Life

Author

Oluwagbemigun, Kolade, Anesi, Andrea, Vrhovsek, Urska, Mattivi, Fulvio, Martino Adami, Pamela, Pentzek, Michael, Scherer, Martin, Riedel-Heller, Steffi G., Weyerer, Siegfried, Bickel, Horst, Wiese, Birgitt, Schmid, Matthias, Cryan, John F., Ramirez, Alfredo, Wagner, Michael, and Nöthlings, Ute

Published
2024
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15. Dietary changes following a lifestyle-based intervention for dementia risk reduction – results from the AgeWell.de study

Author

Zülke, Andrea E., Blotenberg, Iris, Luppa, Melanie, Löbner, Margrit, Döhring, Juliane, Williamson, Martin, Kosilek, Robert P., Michel, Irina, Oey, Anke, Brettschneider, Christian, Gensichen, Jochen, Czock, David, Wiese, Birgitt, König, Hans-Helmut, Frese, Thomas, Kaduszkiewicz, Hanna, Hoffmann, Wolfgang, Thyrian, René, and Riedel-Heller, Steffi G.

Published
2025
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16. [Not Available].

Author

Van Asbroeck, Stephanie, Köhler, Sebastian, van Boxtel, Martin, Lipnicki, Darren, Crawford, John, Castro-Costa, Erico, Lima-Costa, Maria, Blay, Sergio, Shifu, Xiao, Wang, Tao, Yue, Ling, Lipton, Richard, Katz, Mindy, Derby, Carol, Guerchet, Maëlenn, Preux, Pierre-Marie, Mbelesso, Pascal, Norton, Joanna, Ritchie, Karen, Skoog, Ingmar, Najar, Jenna, Sterner, Therese, Scarmeas, Nikolaos, Yannakoulia, Mary, Dardiotis, Themis, Rolandi, Elena, Davin, Annalisa, Rossi, Michele, Gureje, Oye, Ojagbemi, Akin, Bello, Toyin, Kim, Ki, Han, Ji, Oh, Dae, Trompet, Stella, Gussekloo, Jacobijn, Riedel-Heller, Steffi, Röhr, Susanne, Pabst, Alexander, Shahar, Suzana, Rivan, Nurul, Singh, Devinder, Jacobsen, Erin, Ganguli, Mary, Hughes, Tiffany, Haan, Mary, Aiello, Allison, Ding, Ding, Zhao, Qianhua, Xiao, Zhenxu, Narazaki, Kenji, Chen, Tao, Chen, Sanmei, Ng, Tze, Gwee, Xinyi, Gao, Qi, Brodaty, Henry, Trollor, Julian, Kochan, Nicole, Lobo, Antonio, Santabárbara, Javier, Gracia-Garcia, Patricia, Sachdev, Perminder, and Deckers, Kay

Subjects
age, dementia, dementia risk reduction, education, effect modification, ethnicity, individual participant data meta‐analysis, interaction, lifestyle, primary prevention, region, risk factor, risk personalization, sex, socioeconomic, Humans, Dementia, Life Style, Male, Female, Risk Factors, Aged, Prospective Studies, Incidence
Abstract

INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.

Published
2024

18. Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial

Author

Kosilek, Robert P., Wendel, Flora, Zöllinger, Isabel, Knecht, Hanna Lea, Blotenberg, Iris, Weise, Solveig, Fankhänel, Thomas, Döhring, Juliane, Williamson, Martin, Luppa, Melanie, Zülke, Andrea E., Brettschneider, Christian, Wiese, Birgitt, Hoffmann, Wolfgang, Frese, Thomas, König, Hans-Helmut, Kaduszkiewicz, Hanna, Thyrian, Jochen René, Riedel-Heller, Steffi G., and Gensichen, Jochen

Published
2024
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19. Quality of life in a high-risk group of elderly primary care patients: characteristics and potential for improvement

Author

Döhring, Juliane, Williamson, Martin, Brettschneider, Christian, Fankhänel, Thomas, Luppa, Melanie, Pabst, Alexander, Weißenborn, Marina, Zöllinger, Isabel, Czock, David, Frese, Thomas, Gensichen, Jochen, Hoffmann, Wolfgang, König, Hans-Helmut, Thyrian, Jochen René, Wiese, Birgitt, Riedel-Heller, Steffi, and Kaduszkiewicz, Hanna

Published
2024
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21. Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway

Author

Choe, Kyonghwan, Ali, Muhammad, Lardenoije, Roy, Riemens, Renzo J.M., Pishva, Ehsan, Bickel, Horst, Weyerer, Siegfried, Hoffmann, Per, Pentzek, Michael, Riedel-Heller, Steffi, Wiese, Birgitt, Scherer, Martin, Wagner, Michael, Mastroeni, Diego, Coleman, Paul D., Ramirez, Alfredo, Ramakers, Inez H.G.B., Verhey, Frans R.J., Rutten, Bart P.F., Kenis, Gunter, and van den Hove, Daniel L.A.

Published
2024
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22. General practitioners’ perspectives on lifestyle interventions for cognitive preservation in dementia prevention

Author

Kappe, Josefine, Wittmann, Felix, Luppa, Melanie, Cardona, Maria Isabel, Weise, Solveign, Fuchs, Stephan, Kosilek, Robert Philipp, Sanftenberg, Linda, Brettschneider, Christian, Döhring, Juliane, Escales, Catharina, Czock, David, Wiese, Birgitt, Thyrian, Jochen René, Hoffmann, Wolfgang, Frese, Thomas, Gensichen, Jochen, König, Hans-Helmut, Kaduszkiewicz, Hanna, and Riedel-Heller, Steffi Gerlinde

Published
2024
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26. Adherence to a lifestyle intervention – just a question of self-efficacy? Analysis of the AgeWell.de-intervention against cognitive decline

Author

Wittmann, Felix G., Pabst, Alexander, Zülke, Andrea, Luppa, Melanie, Oey, Anke, Boekholt, Melanie, Weise, Solveig, Fankhänel, Thomas, Kosilek, Robert P., Brettschneider, Christian, Döhring, Juliane, Lunden, Laura, Wiese, Birgitt, Hoffmann, Wolfgang, Frese, Thomas, Gensichen, Jochen, König, Hans-Helmut, Kaduszkiewicz, Hanna, Thyrian, Jochen René, and Riedel-Heller, Steffi G.

Published
2024
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29. Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium.

Author

Gong, Jessica, Harris, Katie, Lipnicki, Darren, Castro-Costa, Erico, Lima-Costa, Maria, Diniz, Breno, Xiao, Shifu, Lipton, Richard, Katz, Mindy, Wang, Cuiling, Preux, Pierre-Marie, Guerchet, Maëlenn, Gbessemehlan, Antoine, Ritchie, Karen, Ancelin, Marie-Laure, Skoog, Ingmar, Najar, Jenna, Sterner, Therese, Scarmeas, Nikolaos, Yannakoulia, Mary, Kosmidis, Mary, Guaita, Antonio, Rolandi, Elena, Davin, Annalisa, Gureje, Oye, Trompet, Stella, Gussekloo, Jacobijn, Riedel-Heller, Steffi, Pabst, Alexander, Röhr, Susanne, Shahar, Suzana, Singh, Devinder, Rivan, Nurul, Boxtel, Martin, Köhler, Sebastian, Ganguli, Mary, Chang, Chung-Chou, Jacobsen, Erin, Ding, Ding, Zhao, Qianhua, Xiao, Zhenxu, Narazaki, Kenji, Chen, Tao, Chen, Sanmei, Ng, Tze, Gwee, Xinyi, Numbers, Katya, Mather, Karen, Scazufca, Marcia, Lobo, Antonio, De-la-Cámara, Concepción, Lobo, Elena, Sachdev, Perminder, Brodaty, Henry, Hackett, Maree, Peters, Sanne, Woodward, Mark, and Haan, Mary

Subjects
data harmonization, dementia, diversity, risk factor, sex difference, Humans, Male, Female, Sex Characteristics, Risk Factors, Alcohol Drinking, Dementia, Sex Factors
Abstract

INTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.

Published
2023

31. Social isolation in the oldest-old: determinants and the differential role of family and friends

Author

Moormann, Katharina Isabelle, Pabst, Alexander, Bleck, Franziska, Löbner, Margrit, Kaduszkiewicz, Hanna, van der Leeden, Carolin, Hajek, André, Brettschneider, Christian, Heser, Kathrin, Kleineidam, Luca, Werle, Jochen, Fuchs, Angela, Weeg, Dagmar, Bickel, Horst, Pentzek, Michael, Weyerer, Siegfried, Wiese, Birgitt, Wagner, Michael, Maier, Wolfgang, Scherer, Martin, König, Hans-Helmut, and Riedel-Heller, Steffi G.

Published
2024
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37. The relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual-participant data from 15 international studies.

Author

Mewton, Louise, Visontay, Rachel, Hoy, Nicholas, Lipnicki, Darren, Sunderland, Matthew, Lipton, Richard, Guerchet, Maëlenn, Ritchie, Karen, Najar, Jenna, Scarmeas, Nikolaos, Kim, Ki-Woong, Riedel Heller, Steffi, van Boxtel, Martin, Jacobsen, Erin, Brodaty, Henry, Anstey, Kaarin, Scazufca, Marcia, Lobo, Elena, Sachdev, Perminder, and Haan, Mary

Subjects
Alcohol, cross-national comparison, dementia, epidemiology, individual participant data meta-analysis, older adults, Humans, Female, Aged, Middle Aged, Aged, 80 and over, Male, Prospective Studies, Alcohol Drinking, Ethanol, Proportional Hazards Models, Dementia, Risk Factors
Abstract

AIM: To synthesize international findings on the alcohol-dementia relationship, including representation from low- and middle-income countries. METHODS: Individual participant data meta-analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. Cox regression investigated the dementia risk associated with alcohol use in older adults aged over 60 years. Additional analyses assessed the alcohol-dementia relationship in the sample stratified by sex and by continent. Participants included 24 478 community dwelling individuals without a history of dementia at baseline and at least one follow-up dementia assessment. The main outcome measure was all-cause dementia as determined by clinical interview. RESULTS: At baseline, the mean age across studies was 71.8 (standard deviation = 7.5, range = 60-102 years), 14 260 (58.3%) were female and 13 269 (54.2%) were current drinkers. During 151 636 person-years of follow-up, there were 2124 incident cases of dementia (14.0 per 1000 person-years). When compared with abstainers, the risk for dementia was lower in occasional [hazard ratio (HR) = 0.78; 95% confidence interval (CI) = 0.68-0.89], light-moderate (HR = 0.78; 95% CI = 0.70-0.87) and moderate-heavy drinkers (HR = 0.62; 95% CI = 0.51-0.77). There was no evidence of differences between life-time abstainers and former drinkers in terms of dementia risk (HR = 0.98; 95% CI = 0.81-1.18). In dose-response analyses, moderate drinking up to 40 g/day was associated with a lower risk of dementia when compared with lif-time abstaining. Among current drinkers, there was no consistent evidence for differences in terms of dementia risk. Results were similar when the sample was stratified by sex. When analysed at the continent level, there was considerable heterogeneity in the alcohol-dementia relationship. CONCLUSIONS: Abstinence from alcohol appears to be associated with an increased risk for all-cause dementia. Among current drinkers, there appears to be no consistent evidence to suggest that the amount of alcohol consumed in later life is associated with dementia risk.

Published
2023

38. The effect of depressive symptoms on quality of life and its different facets in the oldest age population: evidence from the AgeQualiDe prospective cohort study

Author

Liegert, Paula, Pabst, Alexander, Conrad, Ines, van den Bussche, Hendrik, Eisele, Marion, Hajek, André, Heser, Kathrin, Kleineidam, Luca, Weyerer, Siegfried, Werle, Jochen, Pentzek, Michael, Weeg, Dagmar, Mösch, Edelgard, Wiese, Birgitt, Oey, Anke, Wagner, Michael, Maier, Wolfgang, König, Hans-Helmut, Riedel-Heller, Steffi G., Scherer, Martin, and Luppa, Melanie

Published
2024
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39. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Author

Holstege, Henne, Hulsman, Marc, Charbonnier, Camille, Grenier-Boley, Benjamin, Quenez, Olivier, Grozeva, Detelina, van Rooij, Jeroen GJ, Sims, Rebecca, Ahmad, Shahzad, Amin, Najaf, Norsworthy, Penny J, Dols-Icardo, Oriol, Hummerich, Holger, Kawalia, Amit, Amouyel, Philippe, Beecham, Gary W, Berr, Claudine, Bis, Joshua C, Boland, Anne, Bossù, Paola, Bouwman, Femke, Bras, Jose, Campion, Dominique, Cochran, J Nicholas, Daniele, Antonio, Dartigues, Jean-François, Debette, Stéphanie, Deleuze, Jean-François, Denning, Nicola, DeStefano, Anita L, Farrer, Lindsay A, Fernández, Maria Victoria, Fox, Nick C, Galimberti, Daniela, Genin, Emmanuelle, Gille, Johan JP, Le Guen, Yann, Guerreiro, Rita, Haines, Jonathan L, Holmes, Clive, Ikram, M Arfan, Ikram, M Kamran, Jansen, Iris E, Kraaij, Robert, Lathrop, Marc, Lemstra, Afina W, Lleó, Alberto, Luckcuck, Lauren, Mannens, Marcel MAM, Marshall, Rachel, Martin, Eden R, Masullo, Carlo, Mayeux, Richard, Mecocci, Patrizia, Meggy, Alun, Mol, Merel O, Morgan, Kevin, Myers, Richard M, Nacmias, Benedetta, Naj, Adam C, Napolioni, Valerio, Pasquier, Florence, Pastor, Pau, Pericak-Vance, Margaret A, Raybould, Rachel, Redon, Richard, Reinders, Marcel JT, Richard, Anne-Claire, Riedel-Heller, Steffi G, Rivadeneira, Fernando, Rousseau, Stéphane, Ryan, Natalie S, Saad, Salha, Sanchez-Juan, Pascual, Schellenberg, Gerard D, Scheltens, Philip, Schott, Jonathan M, Seripa, Davide, Seshadri, Sudha, Sie, Daoud, Sistermans, Erik A, Sorbi, Sandro, van Spaendonk, Resie, Spalletta, Gianfranco, Tesi, Niccolo’, Tijms, Betty, Uitterlinden, André G, van der Lee, Sven J, Visser, Pieter Jelle, Wagner, Michael, Wallon, David, Wang, Li-San, Zarea, Aline, Clarimon, Jordi, van Swieten, John C, Greicius, Michael D, Yokoyama, Jennifer S, Cruchaga, Carlos, Hardy, John, and Ramirez, Alfredo

Subjects
Biological Sciences, Genetics, Dementia, Alzheimer's Disease, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Human Genome, Prevention, Acquired Cognitive Impairment, Neurodegenerative, Aging, Clinical Research, Biotechnology, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Humans, Adenosine Triphosphatases, Alzheimer Disease, ATP Binding Cassette Transporter 1, Genome-Wide Association Study, Risk Factors, Exosomes, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Alzheimer's disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70%1. The genetic component of AD has been mainly assessed using genome-wide association studies, which do not capture the risk contributed by rare variants2. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals-16,036 AD cases and 16,522 controls. Next to variants in TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Additionally, the rare-variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential drivers of respective AD-genome-wide association study loci. Variants associated with the strongest effect on AD risk, in particular loss-of-function variants, are enriched in early-onset AD cases. Our results provide additional evidence for a major role for amyloid-β precursor protein processing, amyloid-β aggregation, lipid metabolism and microglial function in AD.

Published
2022

42. Independent and joint associations of cardiometabolic multimorbidity and depression on cognitive function: findings from multi-regional cohorts and generalisation from community to clinic

Author

Zhao, Xuhao, Xu, Xiaolin, Yan, Yifan, Lipnicki, Darren M., Pang, Ting, Crawford, John D., Chen, Christopher, Cheng, Ching-Yu, Venketasubramanian, Narayanaswamy, Chong, Eddie, Blay, Sergio Luis, Lima-Costa, Maria Fernanda, Castro-Costa, Erico, Lipton, Richard B., Katz, Mindy J., Ritchie, Karen, Scarmeas, Nikolaos, Yannakoulia, Mary, Kosmidis, Mary H., Gureje, Oye, Ojagbemi, Akin, Bello, Toyin, Hendrie, Hugh C., Gao, Sujuan, Guerra, Ricardo Oliveira, Auais, Mohammad, Gomez, José Fernando, Rolandi, Elena, Davin, Annalisa, Rossi, Michele, Riedel-Heller, Steffi G., Löbner, Margit, Roehr, Susanne, Ganguli, Mary, Jacobsen, Erin P., Chang, Chung-Chou H., Aiello, Allison E., Ho, Roger, Sanchez-Juan, Pascual, Valentí-Soler, Meritxell, Ser, Teodoro del, Lobo, Antonio, De-la-Cámara, Concepción, Lobo, Elena, Sachdev, Perminder S., and Xu, Xin

Published
2024
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43. Comparison of Patient Health Questionnaire-9, Edinburgh Postnatal Depression Scale and Hospital Anxiety and Depression – Depression subscale scores by administration mode: An individual participant data differential item functioning meta-analysis

Author

Azar, Marleine, Bhandari, Parash Mani, Chiovitti, Matthew J., He, Chen, Imran, Mahrukh, Krishnan, Ankur, Negeri, Zelalem, Neupane, Dipika, Riehm, Kira E., Yan, Xin Wei, Kloda, Lorie A., Henry, Melissa, Ismail, Zahinoor, Loiselle, Carmen G., Mitchell, Nicholas D., Al-Adawi, Samir, Alvarado, Rubén, Amtmann, Dagmar, Arroll, Bruce, Ayalon, Liat, Baradaran, Hamid R., Barnes, Jacqueline, Beck, Kevin R., Beck, Cheryl Tatano, Bernstein, Charles N., Bindt, Carola, Bombardier, Charles H., Boye, Birgitte, Büel-Drabe, Natalie, Buji, Ryna Imma, Bunevicius, Adomas, Butterworth, Peter, Can, Ceyhun, Carter, Gregory, Chagas, Marcos H., Chan, Juliana C.N., Chan, Lai Fong, Chen, Chih-Ken, Chibanda, Dixon, Chorwe-Sungani, Genesis, Clover, Kerrie, Conroy, Ronán M., Conway, Aaron, Conwell, Yeates, Correa, Humberto, Couto, Thiago Castro e, Cukor, Daniel, Daray, Federico M., de Man-van Ginkel, Janneke M., De Souza, Jennifer, Downing, Marina G., Eapen, Valsamma, Fann, Jesse R., Favez, Nicolas, Felice, Ethel, Fellmeth, Gracia, Ferentinos, Panagiotis P., Fernandes, Michelle, Field, Sally, Figueiredo, Barbara, Fischer, Felix H., Fisher, Jane R.W., Flint, Alastair J., Fujimori, Maiko, Fung, Daniel S.S., Gallagher, Pamela, Gandy, Milena, Gelaye, Bizu, Gholizadeh, Leila, Gibson, Lorna J., Goodyear-Smith, Felicity, Grassi, Luigi, Green, Eric P., Greeno, Catherine G., Hall, Brian J., Hantsoo, Liisa, Haroz, Emily E., Härter, Martin, Hegerl, Ulrich, Helle, Nadine, Hernando, Asuncion, Hides, Leanne, Hobfoll, Stevan E., Honikman, Simone, Howard, Louise M., Hyphantis, Thomas, Iglesias-González, Maria, Inagaki, Masatoshi, Jenewein, Josef, Jeon, Hong Jin, Jetté, Nathalie, Julião, Miguel, Kettunen, Pirjo A., Khamseh, Mohammad E., Kiely, Kim M., Kim, Sung-Wan, Kjærgaard, Marie, Kohlhoff, Jane, Kohrt, Brandon A., König, Hans-Helmut, Kozinszky, Zoltán, Kwan, Yunxin, Lamers, Femke, Lara, María Asunción, Leonardou, Angeliki A., Levin-Aspenson, Holly F., Liu, Shen-Ing, Löbner, Margrit, Loosman, Wim L., Lotrakul, Manote, Loureiro, Sonia R., Love, Anthony W., Löwe, Bernd, Luitel, Nagendra P., Lund, Crick, Maes, Michael, Malt, Ulrik F., Marrie, Ruth Ann, Marsh, Laura, Martínez, Pablo, Marx, Brian P., Matsuoka, Yutaka, McGuire, Anthony, Mehnert, Anja, Michopoulos, Ioannis, Sidik, Sherina Mohd, Müller-Nordhorn, Jacqueline, Muramatsu, Kumiko, Radoš, Sandra Nakić, Navarrete, Laura, Nelson, Christian J., Ng, Chong Guan, Nishi, Daisuke, O'Donnell, Meaghan L., O'Rourke, Suzanne J., Osório, Flávia L., Pabst, Alexander, Pasco, Julie A., Pawlby, Susan J., Peceliuniene, Jurate, Pence, Brian W., Persoons, Philippe, Petersen, Inge, Picardi, Angelo, Ponsford, Jennie L., Pugh, Stephanie L., Pulido, Federico, Quinn, Terence J., Quispel, Chantal, Rathod, Sujit D., Reme, Silje E., Reuter, Katrin, Riedel-Heller, Steffi G., Rooney, Alasdair G., Santos, Iná S., Saracino, Rebecca M., Schellekens, Melanie P.J., Schwarzbold, Marcelo L., Cankorur, Vesile Senturk, Shaaban, Juwita, Sharp, Deborah J., Sharpe, Louise, Shinn, Eileen H., Sidebottom, Abbey, Simard, Sébastien, Singer, Susanne, Skalkidou, Alkistis, Smith-Nielsen, Johanne, Spangenberg, Lena, Stafford, Lesley, Stein, Alan, Stewart, Robert C., Strobel, Natalie A., Su, Kuan-Pin, Sultan, Serge, Sundström-Poromaa, Inger, Sung, Sharon C., Suzuki, Keiko, Tadinac, Meri, Tan, Pei Lin Lynnette, Tandon, S. Darius, Taylor-Rowan, Martin, Teixeira, Antonio L., Tendais, Iva, Tiringer, Istvan, Töreki, Annamária, Tran, Thach D., Trevillion, Kylee, Tschorn, Mira, Turner, Alyna, Væver, Mette S., van der Feltz-Cornelis, Christina M., van Heyningen, Thandi, Vega-Dienstmaier, Johann M., Wagner, Michael, Wagner, Lynne I., Wang, Liang-Jen, Wang, Jian Li, Watson, David, Weyerer, Siegfried B., White, Jennifer, Whooley, Mary A., Wiese, Birgitt, Williams, Lana J., Winkley, Kirsty, Wynter, Karen, Yamada, Mitsuhiko, Yonkers, Kimberly A., Zeng, Qing Zhi, Zhang, Yuying, Harel, Daphna, Wu, Yin, Levis, Brooke, Fan, Suiqiong, Sun, Ying, Xu, Mingyao, Rice, Danielle B., Boruff, Jill, Markham, Sarah, Ioannidis, John P.A., Takwoingi, Yemisi, Patten, Scott B., Ziegelstein, Roy C., Cuijpers, Pim, Gilbody, Simon, Vigod, Simone, Akena, Dickens, Benedetti, Andrea, and Thombs, Brett D.

Published
2024
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44. Individual patient data meta-analysis estimates the minimal detectable change of the Geriatric Depression Scale-15

Author

Krishnan, Ankur, He, Chen, Santo, Tiffany Dal, Neupane, Dipika, Brehaut, Eliana, Bhandari, Parash M., Qiu, Xia, Li, Letong, Imran, Mahrukh, Nassar, Elsa-Lynn, Adams, Kathryn Betts, Allgaier, Antje-Kathrin, Baillon, Sarah F., Caramelli, Paulo, Castro-Costa, Erico, Chagas, Marcos H.N., Cullum, Sarah, Dias, Filipi L.C., Isik, Ahmet Turan, Jetté, Nathalie, Katz, Patricia, Kim, Wonhyoung, König, Hans-Helmut, Lima-Costa, Maria Fernanda, Löbner, Margrit, Malakouti, Seyed Kazem, Marsh, Laura, Moon, Heehyul E., Mougias, Antonis A., Nelson, Christian J., Pabst, Alexander, Quinn, Terence J., Riedel-Heller, Steffi G., Saracino, Rebecca, Scherer, Martin, Volz, Matthias, Wagner, Michael, Weyerer, Siegfried B., González-Domínguez, Nadia P., Wu, Yin, Fan, Suiqiong, Levis, Brooke, Sun, Ying, Gilbody, Simon, Ioannidis, John P.A., Harel, Daphna, Vigod, Simone N., Markham, Sarah, Ziegelstein, Roy C., Cuijpers, Pim, Patten, Scott B., Boruff, Jill T., Thombs, Brett D., and Benedetti, Andrea

Published
2024
Full Text
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