Search

Your search keyword '"Rieder, Florian"' showing total 1,288 results
Start Over Author "Rieder, Florian"
1,288 results on '"Rieder, Florian"'

2. A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice

Author

Bettenworth, Dominik, Baker, Mark E., Fletcher, Joel G., Jairath, Vipul, Lu, Cathy, Bemelman, Willem, d’Haens, Geert, d’Hoore, Andre, Dignass, Axel, Dotan, Iris, Feakins, Roger, Fleshner, Phillip, Ha, Christina, Henderson, Gaylyn, Lyu, Ruishen, Panes, Julian, Rogler, Gerhard, Mao, Ren, Rimola, Jordi, Sandborn, William J., Ng, Siew C., Siegmund, Britta, Silverberg, Mark, Taylor, Stuart A., Verstockt, Bram, Gordon, Ilyssa O., Bruining, David H., Feagan, Brian G., and Rieder, Florian

Published
2024
Full Text
View/download PDF

5. MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes

Author

Datta, Ritwik, Gholampour, Mohammad A, Yang, Christopher D, Volk, Regan, Lin, Sinan, Podolsky, Michael J, Arnold, Thomas, Rieder, Florian, Zaro, Balyn W, Verzi, Michael, Lehner, Richard, Abumrad, Nada, Lizama, Carlos O, and Atabai, Kamran

Subjects
Biochemistry and Cell Biology, Biological Sciences, Nutrition, Underpinning research, 1.1 Normal biological development and functioning, Animals, Mice, Antigens, Surface, Dietary Fats, Enterocytes, Fatty Acids, Hydrolases, Lipid Droplets, Lipid Metabolism, Milk Proteins, Transcription Factors, Triglycerides, CES1, CP: Metabolism, CP: Molecular biology, HNF4γ, MFGE8, dietary lipids, enterocytes, integrins, lipid droplets, postprandial lipemia, triglyceride hydrolases, Medical Physiology, Biological sciences
Abstract

Enterocytes modulate the extent of postprandial lipemia by storing dietary fats in cytoplasmic lipid droplets (cLDs). We have previously shown that the integrin ligand MFGE8 links absorption of dietary fats with activation of triglyceride (TG) hydrolases that catabolize cLDs for chylomicron production. Here, we identify CES1D as the key hydrolase downstream of the MFGE8-αvβ5 integrin pathway that regulates catabolism of diet-derived cLDs. Mfge8 knockout (KO) enterocytes have reduced CES1D transcript and protein levels and reduced protein levels of the transcription factor HNF4γ. Both Ces1d and Hnf4γ KO mice have decreased enterocyte TG hydrolase activity coupled with retention of TG in cLDs. Mechanistically, MFGE8-dependent fatty acid uptake through CD36 stabilizes HNF4γ protein level; HNF4γ then increases Ces1d transcription. Our work identifies a regulatory network that regulates the severity of postprandial lipemia by linking dietary fat absorption with protein stabilization of a transcription factor that increases expression of hydrolases responsible for catabolizing diet-derived cLDs.

Published
2023

6. International expert guidance for defining and monitoring small bowel strictures in Crohn's disease on intestinal ultrasound: a consensus statement

Author

Lu, Cathy, Rosentreter, Ryan, Parker, Claire E, Remillard, Julie, Wilson, Stephanie R, Baker, Mark E, Bhatnagar, Gauraang, Begun, Jakob, Bruining, David H, Bryant, Robert V, Christensen, Britt, Feagan, Brian G, Fletcher, Joel G, Gordon, Ilyssa, Henderson, Gaylyn, Jairath, Vipul, Knudsen, John, Kucharzik, Torsten, Lesack, Kyle, Maaser, Christian, Maconi, Giovanni, Novak, Kerri, Rimola, Jordi, Taylor, Stuart A, Wilkens, Rune, and Rieder, Florian

Published
2024
Full Text
View/download PDF

9. Patients With Low Drug Levels or Antibodies to a Prior Anti–Tumor Necrosis Factor Are More Likely to Develop Antibodies to a Subsequent Anti–Tumor Necrosis Factor

Author

Vande Casteele, Niels, Abreu, Maria T, Flier, Sarah, Papamichael, Konstantinos, Rieder, Florian, Silverberg, Mark S, Khanna, Reena, Okada, Lauren, Yang, Lei, Jain, Anjali, and Cheifetz, Adam S

Subjects
Biomedical and Clinical Sciences, Immunology, Autoimmune Disease, Digestive Diseases, Biotechnology, Prevention, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Good Health and Well Being, Adalimumab, Autoantibodies, Drug Monitoring, Genome-Wide Association Study, Humans, Inflammatory Bowel Diseases, Infliximab, Tumor Necrosis Factor Inhibitors, Clinical Sciences, Gastroenterology & Hepatology, Clinical sciences
Abstract

Therapeutic drug monitoring (TDM) with measurement of serum drug and antidrug antibodies (ADAb) is used widely to confirm therapeutic exposure, rule out immunogenicity, and optimize treatment of biologics in patients with inflammatory bowel diseases.1 A recent genome-wide association study found the variant HLA-DQA1∗05 to increase the risk of development of antibodies against infliximab (IFX) and adalimumab (ADM) 2-fold, regardless of concomitant immunomodulator use.2,3 However, there is currently limited evidence showing whether patients who develop antibodies to 1 anti-tumor necrosis factor (TNF) are prone to develop antibodies to the subsequent anti-TNF. Our aim was to investigate the risk of subsequent antibody development in cases (with ADAb to prior anti-TNF) versus control subjects (without ADAb to prior anti-TNF) using a large cohort of patients with inflammatory bowel diseases who underwent TDM with a drug-tolerant assay.

Published
2022

10. Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2

Author

Xie, Ying, Fontenot, Lindsey, Estrada, Andrea Chupina, Nelson, Becca, Wang, Jiani, Shih, David Q, Ho, Wendy, Mattai, S Anjani, Rieder, Florian, Jensen, Dane D, Bunnett, Nigel W, and Koon, Wai

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Nutrition, Inflammatory Bowel Disease, Clinical Research, Crohn's Disease, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Animals, Cathepsins, Collagen, Constriction, Pathologic, Crohn Disease, Elafin, Fibrosis, Humans, Intestinal Obstruction, Intestines, Mice, Peptide Hydrolases, Polymethacrylic Acids, Protease Inhibitors, Proteome, Receptor, PAR-2, Trinitrobenzenesulfonic Acid, Zinc Finger E-box-Binding Homeobox 1, Protease, Receptor, Biochemistry and cell biology, Clinical sciences
Abstract

Background & aimsMore than half of Crohn's disease patients develop intestinal fibrosis-induced intestinal strictures. Elafin is a human protease inhibitor that is down-regulated in the stricturing intestine of Crohn's disease patients. We investigated the efficacy of elafin in reversing intestinal fibrosis and elucidated its mechanism of action.MethodsWe developed a new method to mimic a stricturing Crohn's disease environment and induce fibrogenesis using stricturing Crohn's disease patient-derived serum exosomes to condition fresh human intestinal tissues and primary stricturing Crohn's disease patient-derived intestinal fibroblasts. Three mouse models of intestinal fibrosis, including SAMP1/YitFc mice, Salmonella-infected mice, and trinitrobenzene sulfonic acid-treated mice, were also studied. Elafin-Eudragit FS30D formulation and elafin-overexpressing construct and lentivirus were used.ResultsElafin reversed collagen synthesis in human intestinal tissues and fibroblasts pretreated with Crohn's disease patient-derived serum exosomes. Proteome arrays identified cathepsin S as a novel fibroblast-derived pro-fibrogenic protease. Elafin directly suppressed cathepsin S activity to inhibit protease-activated receptor 2 activity and Zinc finger E-box-binding homeobox 1 expression, leading to reduced collagen expression in intestinal fibroblasts. Elafin overexpression reversed ileal fibrosis in SAMP1/YitFc mice, cecal fibrosis in Salmonella-infected mice, and colonic fibrosis in trinitrobenzene sulfonic acid-treated mice. Cathepsin S, protease-activated receptor 2 agonist, and zinc finger E-box-binding homeobox 1 overexpression abolished the anti-fibrogenic effect of elafin in fibroblasts and all 3 mouse models of intestinal fibrosis. Oral elafin-Eudragit FS30D treatment abolished colonic fibrosis in trinitrobenzene sulfonic acid-treated mice.ConclusionsElafin suppresses collagen synthesis in intestinal fibroblasts via cathepsin S-dependent protease-activated receptor 2 inhibition and decreases zinc finger E-box-binding homeobox 1 expression. The reduced collagen synthesis leads to the reversal of intestinal fibrosis. Thus, modified elafin may be a therapeutic approach for intestinal fibrosis.

Published
2022

15. Stricturing Crohn’s Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions

Author

Mukherjee, Pranab K., Nguyen, Quang Tam, Li, Jiannan, Zhao, Shuai, Christensen, Stephen M., West, Gail A., Chandra, Jyotsna, Gordon, Ilyssa O., Lin, Sinan, Wang, Jie, Mao, Ren, Czarnecki, Douglas, Rayan, Carla, Goren, Idan, Banerjee, Suhanti, Kotak, Prerna, Plesec, Thomas, Lal, Samir, Fabre, Thomas, Asano, Shoh, Bound, Kathryn, Hart, Kevin, Park, Chanyoung, Martinez, Robert, Dower, Ken, Wynn, Thomas A., Hu, Shaomin, Naydenov, Nayden, Decaris, Martin, Turner, Scott, Holubar, Stefan D., Steele, Scott R., Fiocchi, Claudio, Ivanov, Andrei I., Kravarik, Kellie M., and Rieder, Florian

Published
2023
Full Text
View/download PDF

16. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis

Author

Akar, Alaa, Flemming, Cornelius, Felix, Flomm, Flosbach, Markus, Jäger, Julia, Jeromin, Niklas, Jung, Johannes, Ohms, Mareike, Reinshagen, Konrad, Rische, Johann, Sagebiel, Adrian, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Wesche, Jasmin, Shifteh Abedian, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Alberts, Rudi, Alizadeh, Behrooz, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bethge, Johannes, Bewshea, Claire, Bis, Joshua C., Bitton, Alain, BK, Thelma, Boucher, Gabrielle, Brain, Oliver, Brand, Stephan, Brant, Steven R., Cheon, Jae Hee, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Cooney, Rachel, Croft, Anthony, Daly, Mark J., D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Degenhardt, Frauke, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Drummond, Hazel E., Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Ellinghaus, David, Ellul, Pierre, Esaki, Motohiro, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Franke, Andre, Fuyuno, Yuta, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Goyette, Philippe, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Hold, Georgina L., Hong, Myhunghee, Hu, Xinli, Huang, Hailiang, Hugot, Jean-Pierre, Hui, Ken Y., Imielinski, Marcin, Jazayeri, Omid, Jonaitis, Laimas, Jostins, Luke, Juyal, Garima, Chandra Juyal, Ramesh, Kalla, Rahul, Karlsen, Tom H., Kennedy, Nicholas A., Khan, Mohammed Azam, Kim, Won Ho, Kitazono, Takanari, Kiudelis, Gediminas, Kubo, Michiaki, Kugathasan, Subra, Kupcinskas, Limas, Lamb, Christopher A., de Lange, Katrina M., Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Luo, Yang, Mahy, Gillian, Malekzadeh, Masoud Mohammad, Malekzadeh, Reza, Mansfield, John, Marriott, Suzie, Massey, Dunecan, Mathew, Christopher G., Matsui, Toshiyuki, McGovern, Dermot P.B., van der Meulen, Andrea, Midha, Vandana, Milgrom, Raquel, Mirzaei, Samaneh, Mitrovic, Mitja, Montgomery, Grant W., Mowat, Craig, Müller, Christoph, Newman, William G., Ng, Aylwin, Ng, Siew C., Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nöthen, Markus, Oikonomou, Ioannis, Okou, David, Orchard, Timothy R., Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Urõs, Poustchi, Hossein, Prescott, Natalie J., Proctor, Deborah D., Radford-Smith, Graham, Rahier, Jean- Francois, Regueiro, Miguel, Reinisch, Walter, Rieder, Florian, Rioux, John D., Roberts, Rebecca, Rogler, Gerhard, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Scharl, Michael, Schembri, John, Schreiber, Stefan, Schumm, L. Philip, Scott, Regan, Seielstad, Mark, Shah, Tejas, Sharma, Yashoda, Silverberg, Mark S., Simmons, Alison, Simms, Lisa A., Singh, Abhey, Skieceviciene, Jurgita, van Sommeren, Suzanne, Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sung, Joseph J.Y., Targan, Stephan R., Taylor, Kirstin M., Theatre, Emilie, Torkvist, Leif, Torres, Esther A., Tremelling, Mark, Uhlig, Holm H., Umeno, Junji, Vahedi, Homayon, Vasiliauskas, Eric, Velde, Anje ter, Ventham, Nicholas T., Vermeire, Severine, Verspaget, Hein W., De Vos, Martine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Weersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Wong, Sunny H., Xavier, Ramnik J., Yamazaki, Keiko, Yang, Suk-Kyun, Ye, Byong Duk, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wei, Zhao, Hongyu, Zhao, Zhen Z., Baumdick, Martin E., Niehrs, Annika, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H.M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen P., Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Altfeld, Marcus, and Bunders, Madeleine J.

Published
2023
Full Text
View/download PDF

22. Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation

Author

Lin, Si-Nan, Musso, Alessandro, Wang, Jie, Mukherjee, Pranab K., West, Gail A., Mao, Ren, Lyu, Ruishen, Li, Jiannan, Zhao, Shuai, Elias, Michael, Haberman, Yael, Denson, Lee A., Kugathasan, Subra, Chen, Min-Hu, Czarnecki, Doug, Dejanovic, Dina, Le, Hongnga T., Chandra, Jyotsna, Lipman, Jeremy, Steele, Scott R., Nguyen, Quang Tam, Fiocchi, Claudio, and Rieder, Florian

Published
2022
Full Text
View/download PDF

23. Test Characteristics of Cross-sectional Imaging and Concordance With Endoscopy in Postoperative Crohn’s Disease

Author

Bachour, Salam P., Shah, Ravi S., Lyu, Ruishen, Nakamura, Takahiro, Shen, Michael, Li, Terry, Dane, Bari, Barnes, Edward L., Rieder, Florian, Cohen, Benjamin, Qazi, Taha, Lashner, Bret, Achkar, Jean Paul, Philpott, Jessica, Holubar, Stefan D., Lightner, Amy L., Regueiro, Miguel, Axelrad, Jordan, Baker, Mark E., and Click, Benjamin

Published
2022
Full Text
View/download PDF

27. Serum Extracellular Matrix Molecules and Their Fragments as Biomarkers of Inflammation and Fibrosis in Inflammatory Bowel Diseases: A Systematic Review.

Author

Poulsen, Anja, Ovesen, Pernille Dige, Lu, Cathy, Bettenworth, Dominik, Jairath, Vipul, Feagan, Brian G, Seidelin, Jakob Benedict, and Rieder, Florian

Abstract

Background and Aim Contemporary techniques to assess disease activity or bowel damage in patients with inflammatory bowel disease [IBD], such as endoscopy and imaging, are either invasive or lack accuracy. Non-invasive biomarkers for this purpose remain an unmet medical need. Herein, we provide a comprehensive systematic review of studies evaluating blood extracellular matrix [ECM] biomarkers and their relevance in IBD. Methods We conducted a systematic review of PubMed, EMBASE, Web of Science, and Scopus to identify citations pertaining to ECM biomarkers of IBD up to March 1, 2024. Studies were categorized based on marker subtype and clinical use. Results Thirty-one ECM markers were identified, 28 of which demonstrated the ability to differentiate IBD disease activity. Collagen III emerged as the most extensively investigated [1212 IBD patients], with the degradation marker C3M and deposition marker PRO-C3 being associated with IBD and subtypes. Collagen V markers C5M and PRO-C5 emerged as the most accurate single markers for diagnosis of IBD, with an area under the curve of 0.91 and 0.93, respectively. Overall, studies were characterized by variable endpoints. None of the studies included histological grading of intestinal damage, repair, or fibrosis formation as the primary outcome in relation to the ECM blood markers. Conclusions Multiple ECM markers are linked with IBD and its phenotypes. However, more rigorous study designs and clearly defined endpoints are needed to ensure reproducibility and develop reliable and accurate biomarkers. ECM markers hold promise as they provide a 'window' into transmural tissue remodelling and fibrosis burden, warranting further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Radiomics to Detect Inflammation and Fibrosis on Magnetic Resonance Enterography in Stricturing Crohn's Disease.

Author

Chirra, Prathyush, Sleiman, Joseph, Gandhi, Namita S, Gordon, Ilyssa O, Hariri, Mohsen, Baker, Mark, Ottichilo, Ronald, Bruining, David H, Kurowski, Jacob A, Viswanath, Satish E, and Rieder, Florian

Abstract

Background and Aims Non-invasive cross-sectional imaging via magnetic resonance enterography [MRE] offers excellent accuracy for the diagnosis of stricturing complications in Crohn's disease [CD] but is limited in determining the degrees of fibrosis and inflammation within a stricture. We developed and validated a radiomics-based machine-learning model for separately characterizing the degree of histopathological inflammation and fibrosis in CD strictures and compared it to centrally read visual radiologist scoring of MRE. Methods This single-centre, cross-sectional study included 51 CD patients [ n  = 34 for discovery; n  = 17 for validation] with terminal ileal strictures confirmed on diagnostic MRE within 15 weeks of resection. Histopathological specimens were scored for inflammation and fibrosis and spatially linked with corresponding pre-surgical MRE sequences. Annotated stricture regions on MRE were scored visually by radiologists as well as underwent 3D radiomics-based machine learning analysis; both were evaluated against histopathology. Results Two distinct sets of radiomic features capturing textural heterogeneity within strictures were linked with each of severe inflammation or severe fibrosis across both the discovery (area under the curve [AUC = 0.69, 0.83] and validation [AUC = 0.67, 0.78] cohorts. Radiologist visual scoring had an AUC = 0.67 for identifying severe inflammation and AUC = 0.35 for severe fibrosis. Use of combined radiomics and radiologist scoring robustly augmented identification of severe inflammation [AUC = 0.79] and modestly improved assessment of severe fibrosis [AUC = 0.79 for severe fibrosis] over individual approaches. Conclusions Radiomic features of CD strictures on MRE can accurately identify severe histopathological inflammation and severe histopathological fibrosis, as well as augment performance of the radiologist visual scoring in stricture characterization. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

31. The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis

Author

Kobayashi, Hiroki, Gieniec, Krystyna A., Lannagan, Tamsin R.M., Wang, Tongtong, Asai, Naoya, Mizutani, Yasuyuki, Iida, Tadashi, Ando, Ryota, Thomas, Elaine M., Sakai, Akihiro, Suzuki, Nobumi, Ichinose, Mari, Wright, Josephine A., Vrbanac, Laura, Ng, Jia Q., Goyne, Jarrad, Radford, Georgette, Lawrence, Matthew J., Sammour, Tarik, Hayakawa, Yoku, Klebe, Sonja, Shin, Alice E., Asfaha, Samuel, Bettington, Mark L., Rieder, Florian, Arpaia, Nicholas, Danino, Tal, Butler, Lisa M., Burt, Alastair D., Leedham, Simon J., Rustgi, Anil K., Mukherjee, Siddhartha, Takahashi, Masahide, Wang, Timothy C., Enomoto, Atsushi, Woods, Susan L., and Worthley, Daniel L.

Published
2022
Full Text
View/download PDF

32. Postoperative Crohn’s Disease Recurrence Risk and Optimal Biologic Timing After Temporary Diversion Following Ileocolic Resection

Author

Joseph, Abel, primary, Bachour, Salam P, additional, Shah, Ravi, additional, El Halabi, Jessica, additional, Syed, Hareem, additional, Lyu, Ruishen, additional, Cohen, Benjamin, additional, Rieder, Florian, additional, Achkar, Jean-Paul, additional, Philpott, Jessica, additional, Qazi, Taha, additional, Hull, Tracy, additional, Lipman, Jeremy, additional, Wexner, Steven, additional, Holubar, Stefan D, additional, Regueiro, Miguel, additional, and Click, Benjamin, additional

Published
2024
Full Text
View/download PDF

33. Diagnosis of Inflammatory Bowel Disease–Associated Peripheral Arthritis: A Systematic Review

Author

Falloon, Katherine, primary, Dossaji, Zahra, additional, Mude, Pooja, additional, Abushamma, Suha, additional, Ananthakrishnan, Ashwin, additional, Barnes, Edward L, additional, Bhalla, Jaideep, additional, Bhattacharya, Abhik, additional, Cheemalavagu, Shashank, additional, Colombel, Jean-Fred, additional, Cross, Raymond K, additional, Ermann, Joerg, additional, Ha, Christina, additional, Herfarth, Hans, additional, Horst, Sara, additional, Hou, Jason, additional, Husni, M Elaine, additional, Kline, Theresa M, additional, Kuhn, Kristine A, additional, Long, Millie D, additional, Loftus, Edward V, additional, Lukin, Dana J, additional, Patel, Aditi, additional, Rubin, David T, additional, Scherl, Ellen J, additional, Shah, Samir A, additional, Siaton, Bernadette C, additional, Sleiman, Joseph, additional, Qazi, Taha, additional, Weisman, Michael H, additional, Cohen, Benjamin L, additional, Feagan, Brian G, additional, and Rieder, Florian, additional

Published
2024
Full Text
View/download PDF

34. An International Consensus to Standardize Integration of Histopathology in Ulcerative Colitis Clinical Trials

Author

Ma, Christopher, Sedano, Rocio, Almradi, Ahmed, Vande Casteele, Niels, Parker, Claire E., Guizzetti, Leonardo, Schaeffer, David F., Riddell, Robert H., Pai, Reetesh K., Battat, Robert, Sands, Bruce E., Rosty, Christophe, Dubinsky, Marla C., Rieder, Florian, Harpaz, Noam, Abreu, Maria T., Bryant, Robert V., Lauwers, Gregory Y., Kirsch, Richard, Valasek, Mark A., Crowley, Eileen, Sandborn, William J., Feagan, Brian G., Pai, Rish K., and Jairath, Vipul

Published
2021
Full Text
View/download PDF

35. Development and Validation of a Novel Computed-Tomography Enterography Radiomic Approach for Characterization of Intestinal Fibrosis in Crohn’s Disease

Author

Li, Xuehua, Liang, Dong, Meng, Jixin, Zhou, Jie, Chen, Zhao, Huang, Siyun, Lu, Baolan, Qiu, Yun, Baker, Mark E., Ye, Ziyin, Cao, Qinghua, Wang, Mingyu, Yuan, Chenglang, Chen, Zhihui, Feng, Shengyu, Zhang, Yuxuan, Iacucci, Marietta, Ghosh, Subrata, Rieder, Florian, Sun, Canhui, Chen, Minhu, Li, Ziping, Mao, Ren, Huang, Bingsheng, and Feng, Shi-Ting

Published
2021
Full Text
View/download PDF

38. Three-dimensional Pouchography: A Proof-of-concept Study of a Breakthrough Technique for Visualising Ileoanal Pouch Anatomy and Morphology in Normal and Mechanical Pouch Complication Patients.

Author

Holubar, Stefan D, Nachand, Douglas, Lavryk, Olga, Belkovsky, Mikhael, Brienza, Rita, Mohammed, Nour, Ream, Justin, Hull, Tracy, Steele, Scott R, Regueiro, Miguel, Cohen, Benjamin L, Qazi, Taha, and Rieder, Florian

Abstract

Background Herein, we present a proof-of-concept study of three-dimensional [3D] pouchography using virtual and printed 3D models of ileal pouch-anal anastomosis [IPAA] in patients with normal pouches and in cases of mechanical pouch complications. Methods We performed a retrospective, descriptive case series of a convenience sample of 10 pouch patients with or without pouch dysfunction, who had CT scans appropriate for segmentation who were identified from our pouch registry. The steps involved in clinician-driven automated 3D reconstruction are presented. Results We included three normal patients who underwent CT imaging and were found to have no primary pouch pathology, and seven patients with known pouch pathology identifiable with 3D reconstruction [including pouch strictures, megapouch, pouch volvulus, and twisted pouches], underwent 3D virtual modelling; one normal and one twisted pouch were 3D-printed. We discovered that 3D pouchography reliably identified staple lines [pouch body, anorectal circular and transverse, and tip of J], the relationship between staple lines, and variations in pouch morphology and pouch pathology. Conclusion Three-dimensional reconstruction of IPAA morphology is highly feasible using readily available technology. In our practice, we have found 3D pouchography to be an extremely useful adjunct to diagnose various mechanical pouch complications and improve planning for pouch salvage strategies. Given its ease of use and helpfulness in understanding the pouch structure and function, we have started to routinely integrate 3D pouchography into our clinical pouch referral practice. Further study is needed to formally assess the value of this technique to aid in the diagnosis of pouch pathology. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

39. Muscular hyperplasia in Crohn's disease strictures: through thick and thin.

Author

Veisman, Ido, Massey, William J., Goren, Idan, Liu, Weiwei, Chauhan, Gaurav, and Rieder, Florian

Subjects
CROHN'S disease, SMOOTH muscle, MUSCLE cells, GASTROINTESTINAL system, DRUG target
Abstract

Fibrostenosing Crohn's disease (CD) represents a challenging clinical condition characterized by the development of symptomatic strictures within the gastrointestinal tract. Despite therapeutic advancements in managing inflammation, the progression of fibrostenotic complications remains a significant concern, often necessitating surgical intervention. Recent investigations have unveiled the pivotal role of smooth muscle cell hyperplasia in driving luminal narrowing and clinical symptomatology. Drawing parallels to analogous inflammatory conditions affecting other organs, such as the airways and blood vessels, sheds light on common underlying mechanisms of muscular hyperplasia. This review synthesizes current evidence to elucidate the mechanisms underlying smooth muscle cell proliferation in CD-associated strictures, offering insights into potential therapeutic targets. By highlighting the emerging significance of muscle thickening as a novel therapeutic target, this review aims to inform future research endeavors and clinical strategies with the goal to mitigate the burden of fibrostenotic complications in CD and other conditions. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

42. Preventing fibrosis in IBD: update on immune pathways and clinical strategies.

Author

Wang, Jie, Yang, Bo, Chandra, Jyotsna, Ivanov, Andrei, Brown, J. Mark, and Rieder, Florian

Subjects
CROHN'S disease, INFLAMMATORY bowel diseases, FIBROSIS, ULCERATIVE colitis, CLINICAL drug trials
Abstract

Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases (IBD) driving stricture formation in Crohn's disease patients and leading to submucosal damage in ulcerative colitis. Recent studies provided novel insights into the role of immune and nonimmune components in the pathogenesis of intestinal fibrosis. Those new findings may accelerate the development of anti-fibrotic treatment in IBD patients. This review is designed to cover the recent progress in mechanistic research and therapeutic developments on intestinal fibrosis in IBD patients, including new cell clusters, cytokines, proteins, microbiota, creeping fat, and anti-fibrotic therapies. Due to the previously existing major obstacle of missing consensus on stricture definitions and the absence of clinical trial endpoints, testing of drugs with an anti-fibrotic mechanism is just starting in stricturing Crohn's disease (CD). A biomarker to stratify CD patients at diagnosis without any complications into at-risk populations for future strictures would be highly desirable. Further investigations are needed to identify novel mechanisms of fibrogenesis in the intestine that are targetable and ideally gut specific. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Collagenous Colitis Is Associated With HLA Signature and Shares Genetic Risks With Other Immune-Mediated Diseases

Author

Stahl, Eli, Roda, Giulia, Dobbyn, Amanda, Hu, Jianzhong, Zhang, Zhongyang, Westerlind, Helga, Bonfiglio, Ferdinando, Raj, Towfique, Torres, Joana, Chen, Anli, Petras, Robert, Pardi, Darrell S., Iuga, Alina C., Levi, Gabriel S., Cao, Wenqing, Jain, Prantesh, Rieder, Florian, Gordon, Ilyssa O., Cho, Judy H., D’Amato, Mauro, Harpaz, Noam, Hao, Ke, Colombel, Jean Frederic, and Peter, Inga

Published
2020
Full Text
View/download PDF

47. Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation

Author

Zhao, Shuai, Dejanovic, Dina, Yao, Peng, Bhilocha, Shardul, Sadler, Tammy, Schirbel, Anja, West, Gail, Doyon, Genevieve, Lopez, Rocio, Mao, Ren, Kurada, Satya, El Ouali, Sara, Grassl, Guntram, Fox, Paul L., Cruise, Michael, Worthley, Daniel L., de la Motte, Carol, Fiocchi, Claudio, and Rieder, Florian

Published
2020
Full Text
View/download PDF

48. Histopathology Scoring Systems of Stenosis Associated With Small Bowel Crohn’s Disease: A Systematic Review

Author

Gordon, Ilyssa O., Bettenworth, Dominik, Bokemeyer, Arne, Srivastava, Amitabh, Rosty, Christophe, de Hertogh, Gert, Robert, Marie E., Valasek, Mark A., Mao, Ren, Kurada, Satya, Harpaz, Noam, Borralho, Paula, Pai, Reetesh K., Pai, Rish K., Odze, Robert, Feakins, Roger, Parker, Claire E., Nguyen, Tran, Jairath, Vipul, Baker, Mark E., Bruining, David H., Fletcher, J.G., Feagan, Brian G., and Rieder, Florian

Published
2020
Full Text
View/download PDF

49. Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis

Author

Lin, Sinan, primary, Wang, Jie, additional, Mukherjee, Pranab K, additional, Mao, Ren, additional, West, Gail, additional, Czarnecki, Doug, additional, Zhao, Shuai, additional, Nguyen, Quang Tam, additional, Elias, Michael, additional, Massey, William J, additional, Liu, WeiWei, additional, Wang, Yan, additional, Prasad, Ankita, additional, Banerjee, Suhanti, additional, Goren, Idan, additional, Chandra, Jyotsna, additional, Le, Hongnga T, additional, Dejanovic, Dina, additional, Li, Jiannan, additional, Chen, Minhu, additional, Holubar, Stefan, additional, Olman, Mitchell, additional, Southern, Brian, additional, Hu, Shaomin, additional, Gordon, Ilyssa O, additional, Alabai, Kamran, additional, Fiocchi, Claudio, additional, and Rieder, Florian, additional

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results