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581 results on '"Rieg, Siegbert"'

1. Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023

Author

Zink, Alicia, Hofer, Juliana, Schneider, Christian, Kessler, Franziska, Klenze, Hannes, Klauwer, Dietrich, Maleki, Klaudia, Müller, Andreas, Goretzki, Sarah, Wang, Shubei, Kobbe, Robin, Ramirez, Andrea Vanegas, Bode, Sebastian, Janda, Ales, Fressle, Roland, Remppis, Jonathan, Henneke, Philipp, Rieg, Siegbert, Berger, Anja, Sing, Andreas, Hufnagel, Markus, and Spielberger, Benedikt D.

Published
2024
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2. Role and benefits of infectious diseases specialists in the COVID-19 pandemic: Multilevel analysis of care provision in German hospitals using data from the Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS) cohort

Author

Tscharntke, Lene T., Jung, Norma, Hanses, Frank, Koll, Carolin E. M., Pilgram, Lisa, Rieg, Siegbert, Borgmann, Stefan, de Miranda, Susana M. Nunes, Scherer, Margarete, Spinner, Christoph D., Rüthrich, Maria, Vehreschild, Maria J. G. T., von Bergwelt-Baildon, Michael, Wille, Kai, Merle, Uta, Hower, Martin, Rothfuss, Katja, Nadalin, Silvio, Klinker, Hartwig, Fürst, Julia, Greiffendorf, Ingo, Raichle, Claudia, Friedrichs, Anette, Rauschning, Dominic, de With, Katja, Eberwein, Lukas, Riedel, Christian, Milovanovic, Milena, Worm, Maximilian, Schultheis, Beate, Schubert, Jörg, Bota, Marc, Beutel, Gernot, Glück, Thomas, Schmid, Michael, Wintermantel, Tobias, Peetz, Helga, Steiner, Stephan, Ribel, Elena, Schäfer, Harald, Vehreschild, Jörg Janne, and Stecher, Melanie

Published
2024
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4. Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals: a prospectively evaluated multicentre cohort study from 2016 to 2020 of the R-Net study group

Author

Hornuss, Daniel, Göpel, Siri, Walker, Sarah V., Tobys, David, Häcker, Georg, Seifert, Harald, Higgins, Paul G., Xanthopoulou, Kyriaki, Gladstone, Beryl Primrose, Cattaneo, Chiara, Mischnik, Alexander, Rohde, Anna M., Imirzalioglu, Can, Trauth, Janina, Fritzenwanker, Moritz, Falgenhauer, Jane, Gastmeier, Petra, Behnke, Michael, Kramme, Evelyn, Käding, Nadja, Rupp, Jan, Peter, Silke, Schmauder, Kristina, Eisenbeis, Simone, Kern, Winfried V., Tacconelli, Evelina, and Rieg, Siegbert

Published
2024
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8. Imported Toxigenic Corynebacterium Diphtheriae in Refugees with Polymicrobial Skin Infections, Germany, 2022

Author

Spielberger, Benedikt Daniel, Hansel, Anna, Nazary, Alea, Kleissle, Eva- Maria, Lehr, Claus-Georg, Utz, Marcel, Hofer, Juliana, Rieg, Siegbert, and Kern, Winfried V.

Subjects
Respiratory tract diseases -- Health aspects, Bacterial proteins -- Health aspects, Infection -- Health aspects, Methicillin -- Health aspects -- International trade, Skin -- Health aspects, Resveratrol -- Health aspects, Health
Abstract

Diphtheria is a potentially lethal upper respiratory tract infection that causes systemic illness associated with toxemia. Cases are mostly caused by toxigenic Corynebacterium diphtheriae and, rarely, by C. ulcerans through [...]

Published
2023
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12. Gonorrhoe bei Erwachsenen und Adoleszenten

Author

Bremer, Viviane, Brockmeyer, Norbert H., Buder, Susanne, Eigentler, Angelika, Esser, Stefan, Hagedorn, Hans-Jochen, Hartmann, Martin, Hörauf, Achim, Kern, Winfried, Kohl, Peter K., Köhler, Elisabeth, Köhn, Frank-Michael, Kresken, Michael, Mayr, Christoph, Meyer, Thomas, Möst, Johannes, Mylonas, Ioannis, Nitschke, Heidrun, Petry, Karl-Ulrich, Plettenberg, Andreas, Potthoff, Anja, Rieg, Siegbert, Spornraft-Ragaller, Petra, Rasokat, Heinrich, Schöfer, Helmut, Schneede, Peter, Throm, Waltraud, Walter, Gisela, Weidner, Wolfgang, and Wichelhaus, Thomas A.

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

According to WHO estimates, Neisseria gonorrhoeae accounted for illion infections in 2008, a number of cases approximately matching those of Chlamydia infections. Gonococcal infections thus represent one of the most common causes of sexually transmitted diseases worldwide, second only to trichomonas vaginalis infections.This guideline aims to improve patient care by optimizing the diagnosis and treatment of infections due to Neisseria gonorrhoeae and to raise awareness among medical professionals of current treatment options.

Published
2014
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13. Covid-19 triage in the emergency department 2.0: how analytics and AI transform a human-made algorithm for the prediction of clinical pathways

Author

Bartenschlager, Christina C., Grieger, Milena, Erber, Johanna, Neidel, Tobias, Borgmann, Stefan, Vehreschild, Jörg J., Steinbrecher, Markus, Rieg, Siegbert, Stecher, Melanie, Dhillon, Christine, Ruethrich, Maria M., Jakob, Carolin E. M., Hower, Martin, Heller, Axel R., Vehreschild, Maria, Wyen, Christoph, Messmann, Helmut, Piepel, Christiane, Brunner, Jens O., Hanses, Frank, and Römmele, Christoph

Published
2023
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15. Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial

Author

Valiente, Adoración, de Cueto, Marina, Rodríguez, Ángel, Molina, José, Fischer, Julia, Paul, Gregor, Gallien, Sébastien, Fihman, Vincent, Lacasse, Marion, Coustillères, Francois, Becker, Christian, Fuchs, André, Morata, Laura, Weis, Sebastian, Ponscarme, Diane, Khatchatourian, Lydie, Rouveix, Elisabeth, Merrien, Dominique, Lecomte, Raphaël, Veenemans, Jacobien, Vilchez, Helem H., Kessel, Johanna, Bonten, Marc J.M., Rupp, Jan, Hocqueloux, Laurent, Lucht, Frederic, Stahl, Jean-Paul, Vlek, Anne, Prinz-Langenohl, Reinhild, Tolsma, Violaine, Kaasch, Achim J, López-Cortés, Luis Eduardo, Rodríguez-Baño, Jesús, Cisneros, José Miguel, Dolores Navarro, M, Fätkenheuer, Gerd, Jung, Norma, Rieg, Siegbert, Lepeule, Raphaël, Coutte, Laetitia, Bernard, Louis, Lemaignen, Adrien, Kösters, Katrin, MacKenzie, Colin R, Soriano, Alex, Hagel, Stefan, Fantin, Bruno, Lafaurie, Matthieu, Talarmin, Jean-Philippe, Dinh, Aurélien, Guimard, Thomas, Boutoille, David, Welte, Tobias, Reuter, Stefan, Kluytmans, Jan, Martin, Maria Luisa, Forestier, Emmanuel, Stocker, Hartmut, Vitrat, Virginie, Tattevin, Pierre, Rommerskirchen, Anna, Noret, Marion, Adams, Anne, Kern, Winfried V, Hellmich, Martin, and Seifert, Harald

Published
2024
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16. Ethical and coordinative challenges in setting up a national cohort study during the COVID-19 pandemic in Germany

Author

Tilch, Katharina, Hopff, Sina M., Appel, Katharina, Kraus, Monika, Lorenz-Depiereux, Bettina, Pilgram, Lisa, Anton, Gabi, Berger, Sarah, Geisler, Ramsia, Haas, Kirsten, Illig, Thomas, Krefting, Dagmar, Lorbeer, Roberto, Mitrov, Lazar, Muenchhoff, Maximilian, Nauck, Matthias, Pley, Christina, Reese, Jens-Peter, Rieg, Siegbert, Scherer, Margarete, Stecher, Melanie, Stellbrink, Christoph, Valentin, Heike, Winter, Christof, Witzenrath, Martin, and Vehreschild, J. Janne

Published
2023
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17. Validation of an internationally derived patient severity phenotype to support COVID-19 analytics from electronic health record data

Author

Klann, Jeffrey G, Estiri, Hossein, Weber, Griffin M, Moal, Bertrand, Avillach, Paul, Hong, Chuan, Tan, Amelia LM, Beaulieu-Jones, Brett K, Castro, Victor, Maulhardt, Thomas, Geva, Alon, Malovini, Alberto, South, Andrew M, Visweswaran, Shyam, Morris, Michele, Samayamuthu, Malarkodi J, Omenn, Gilbert S, Ngiam, Kee Yuan, Mandl, Kenneth D, Boeker, Martin, Olson, Karen L, Mowery, Danielle L, Follett, Robert W, Hanauer, David A, Bellazzi, Riccardo, Moore, Jason H, Loh, Ne-Hooi Will, Bell, Douglas S, Wagholikar, Kavishwar B, Chiovato, Luca, Tibollo, Valentina, Rieg, Siegbert, Li, Anthony LLJ, Jouhet, Vianney, Schriver, Emily, Xia, Zongqi, Hutch, Meghan, Luo, Yuan, Kohane, Isaac S, EHR, The Consortium for Clinical Characterization of COVID-19 by, Brat, Gabriel A, and Murphy, Shawn N

Subjects
Health Services and Systems, Health Sciences, Patient Safety, HIV/AIDS, Good Health and Well Being, COVID-19, Electronic Health Records, Hospitalization, Humans, Machine Learning, Prognosis, ROC Curve, Sensitivity and Specificity, Severity of Illness Index, novel coronavirus, disease severity, computable phenotype, medical informatics, data networking, data interoperability, Consortium for Clinical Characterization of COVID-19 by EHR (4CE), Information and Computing Sciences, Engineering, Medical and Health Sciences, Medical Informatics, Biomedical and clinical sciences, Health sciences, Information and computing sciences
Abstract

ObjectiveThe Consortium for Clinical Characterization of COVID-19 by EHR (4CE) is an international collaboration addressing coronavirus disease 2019 (COVID-19) with federated analyses of electronic health record (EHR) data. We sought to develop and validate a computable phenotype for COVID-19 severity.Materials and methodsTwelve 4CE sites participated. First, we developed an EHR-based severity phenotype consisting of 6 code classes, and we validated it on patient hospitalization data from the 12 4CE clinical sites against the outcomes of intensive care unit (ICU) admission and/or death. We also piloted an alternative machine learning approach and compared selected predictors of severity with the 4CE phenotype at 1 site.ResultsThe full 4CE severity phenotype had pooled sensitivity of 0.73 and specificity 0.83 for the combined outcome of ICU admission and/or death. The sensitivity of individual code categories for acuity had high variability-up to 0.65 across sites. At one pilot site, the expert-derived phenotype had mean area under the curve of 0.903 (95% confidence interval, 0.886-0.921), compared with an area under the curve of 0.956 (95% confidence interval, 0.952-0.959) for the machine learning approach. Billing codes were poor proxies of ICU admission, with as low as 49% precision and recall compared with chart review.DiscussionWe developed a severity phenotype using 6 code classes that proved resilient to coding variability across international institutions. In contrast, machine learning approaches may overfit hospital-specific orders. Manual chart review revealed discrepancies even in the gold-standard outcomes, possibly owing to heterogeneous pandemic conditions.ConclusionsWe developed an EHR-based severity phenotype for COVID-19 in hospitalized patients and validated it at 12 international sites.

Published
2021

18. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium

Author

Aaron, James R., Adam, Atif, Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., Angoulvant, François, Anthony, Li LLJ., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Panickan, Vidul Ayakulangara, Azevedo, Paula S., Badenes, Rafael, Balshi, James, Batugo, Ashley, Beaulieu-Jones, Brendin R., Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Boeker, Martin, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Cattelan, Anna Maria, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, García-Barrio, Noelia, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Goh, Rachel SJ., González, Tomás González, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Guzzi, Pietro H., Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Honerlaw, Jacqueline P., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kainth, Mundeep K., Kate, Kernan F., Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Kernan, Kate F., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Makwana, Simran, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Maripuri, Monika, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mazzotti, Diego R., Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku FM., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Ashley C., Pfaff, Emily R., Pillion, Danielle, Pizzimenti, Sara, Priya, Tanu, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Romero-Garcia, Nekane, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin A., Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Sperotto, Francesca, Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia LM., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma MS., Torti, Carlo, Trecarichi, Enrico M., Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zachariasse, Joany M., Zahner, Janet J., Zambelli, Alberto, Zhang, Harrison G., Zöller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Li, Xiudi, Rofeberg, Valerie N., Elias, Matthew D., Laird-Gion, Jessica, and Newburger, Jane W.

Published
2023
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19. Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study

Author

Aaron, James R., Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., François Angoulvant, Anthony, Li L.L.J., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Azevedo, Paula S., Balshi, James, Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, Barrio, Noelia García, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Le, Trang T., Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku F.M., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Emily R., Pfaff, Ashley C., Pillion, Danielle, Pizzimenti, Sara, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin, Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia L.M., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma M.S., Torti, Carlo, Trecarichi, Enrico M., Tseng, Yi-Ju, Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zambelli, Alberto, Zhang, Harrison G., Zo¨ller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Mesa, Rebecca, and Verdy, Guillame

Published
2023
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22. Vancomycin-resistant Enterococcus faecium: admission prevalence, sequence types and risk factors–a cross-sectional study in seven German university hospitals from 2014 to 2018

Author

Bader, Barisch, Biehl, Lena, Buhl, Michael, Dinkelacker, Ariane, Fritzenwanker, Moritz, Gölz, Hanna, Hennelly, Catriona, Herold, Susanne, Lengler, Azita, Lenke, Dana, Peyerl-Hoffmann, Gabriele, Peña Diaz, Luis Alberto, Pilarski, Georg, Proske, Susanna, Schmiedel, Judith, Spitznagel, Heike, Spohn, Katrin, Thoma, Norbert, Vavra, Martina, Wille, Thorsten, Vehreschild, Maria J.G.T., Rohde, Anna M., Walker, Sarah, Behnke, Michael, Eisenbeis, Simone, Falgenhauer, Linda, Falgenhauer, Jane C., Häcker, Georg, Hölzl, Florian, Imirzalioglu, Can, Käding, Nadja, Kern, Winfried V., Kola, Axel, Kramme, Evelyn, Mischnik, Alexander, Peter, Silke, Rieg, Siegbert, Rupp, Jan, Schneider, Christian, Schwab, Frank, Seifert, Harald, Tacconelli, Evelina, Tobys, David, Trauth, Janina, Weber, Anna, Xanthopoulou, Kyriaki, Zweigner, Janine, Higgins, Paul G., and Gastmeier, Petra

Published
2023
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23. Impact of adherence to individual quality-of-care indicators on the prognosis of bloodstream infection due to Staphylococcus aureus: a prospective observational multicentre cohort

Author

Escrihuela-Vidal, Francesc, Kaasch, Achim J., Von Cube, Maja, Rieg, Siegbert, Kern, Winfried V., Seifert, Harald, Song, Kyoung-Ho, Liao, Chun-Hsing, Tilley, Robert, Gott, Hannah, Scarborough, Matt, Gordon, Claire, Llewelyn, Martin J., Kuehl, Richard, Morata, Laura, Soriano, Alex, Edgeworth, Jonathan, De Gopegui, Enrique Ruiz, Nsutebu, Emmanuel, Cisneros, José Miguel, Fowler, Vance G., Thwaites, Guy, López-Contreras, Joaquín, Barlow, Gavin, Ternavasio-De La Vega, Hugo Guillermo, Rodríguez-Baño, Jesús, and López-Cortés, Luis Eduardo

Published
2023
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25. Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies

Author

Akbil, Bengisu, Meyer, Tim, Stubbemann, Paula, Thibeault, Charlotte, Staudacher, Olga, Niemeyer, Daniela, Jansen, Jenny, Mühlemann, Barbara, Doehn, Jan, Tabeling, Christoph, Nusshag, Christian, Hirzel, Cédric, Sanchez, David Sökler, Nieters, Alexandra, Lother, Achim, Duerschmied, Daniel, Schallner, Nils, Lieberum, Jan Nikolaus, August, Dietrich, Rieg, Siegbert, Falcone, Valeria, Hengel, Hartmut, Kölsch, Uwe, Unterwalder, Nadine, Hübner, Ralf-Harto, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Warnatz, Klaus, Spinetti, Thibaud, Schefold, Joerg C., Dörner, Thomas, Sander, Leif Erik, Corman, Victor M., Merle, Uta, Kurth, Florian, von Bernuth, Horst, Meisel, Christian, and Goffinet, Christine

Published
2022
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26. SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals

Author

Lang-Meli, Julia, Luxenburger, Hendrik, Wild, Katharina, Karl, Vivien, Oberhardt, Valerie, Salimi Alizei, Elahe, Graeser, Anne, Reinscheid, Matthias, Roehlen, Natascha, Reeg, David B., Giese, Sebastian, Ciminski, Kevin, Götz, Veronika, August, Dietrich, Rieg, Siegbert, Waller, Cornelius F., Wengenmayer, Tobias, Staudacher, Dawid, Huzly, Daniela, Bengsch, Bertram, Kochs, Georg, Schwemmle, Martin, Emmerich, Florian, Boettler, Tobias, Thimme, Robert, Hofmann, Maike, and Neumann-Haefelin, Christoph

Published
2022
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27. Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease

Author

Gauchel, Nadine, Rieder, Marina, Krauel, Krystin, Goller, Isabella, Jeserich, Maren, Salzer, Ulrich, Venhoff, Ana Cecilia, Baldus, Niklas, Pollmeier, Luisa, Wirth, Luisa, Kern, Winfried, Rieg, Siegbert, Busch, Hans-Jörg, Hofmann, Maike, Bode, Christoph, Duerschmied, Daniel, Lother, Achim, and Heger, Lukas A.

Published
2022
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28. Prediction of COVID-19 deterioration in high-risk patients at diagnosis: an early warning score for advanced COVID-19 developed by machine learning

Author

Jakob, Carolin E. M., Mahajan, Ujjwal Mukund, Oswald, Marcus, Stecher, Melanie, Schons, Maximilian, Mayerle, Julia, Rieg, Siegbert, Pletz, Mathias, Merle, Uta, Wille, Kai, Borgmann, Stefan, Spinner, Christoph D., Dolff, Sebastian, Scherer, Clemens, Pilgram, Lisa, Rüthrich, Maria, Hanses, Frank, Hower, Martin, Strauß, Richard, Massberg, Steffen, Er, Ahmet Görkem, Jung, Norma, Vehreschild, Jörg Janne, Stubbe, Hans, Tometten, Lukas, and König, Rainer

Published
2022
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29. Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study

Author

Lemke, Elke, Thoma, Norbert, Wolke, Solvy, Imirzalioglu, Can, Herold, Susanne, Tewes, Nicole, Fritzenwanker, Moritz, Vehreschild, Jörg Janne, Classen, Annika Yanina, Tobys, David, Higgins, Paul, Blum, Yannic, Kleipaß, Matthias, Höltig, Lisa, Nagel, Katharina, Schmauder, Kristina, Künstle, Larissa, Stoll, Elisabeth, Dinkelacker, Ariane Gertraud, Peyerl-Hoffmann, Gabriele, Häcker, Georg, Spitznagel, Heike, Olawumi-Hurter, Sara Christina, Tacconelli, Evelina, Göpel, Siri, Gladstone, Beryl P, Eisenbeis, Simone, Hölzl, Florian, Buhl, Michael, Górska, Anna, Cattaneo, Chiara, Mischnik, Alexander, Rieg, Siegbert, Rohde, Anna M, Kohlmorgen, Britta, Falgenhauer, Jane, Trauth, Janina, Käding, Nadja, Kramme, Evelyn, Biehl, Lena M, Walker, Sarah V, Peter, Silke, Gastmeier, Petra, Chakraborty, Trinad, Vehreschild, Maria JGT, Seifert, Harald, Rupp, Jan, and Kern, Winfried V

Published
2022
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30. Pre-medication with oral anticoagulants is associated with better outcomes in a large multinational COVID-19 cohort with cardiovascular comorbidities

Author

Rieder, Marina, Gauchel, Nadine, Kaier, Klaus, Jakob, Carolin, Borgmann, Stefan, Classen, Annika Y., Schneider, Jochen, Eberwein, Lukas, Lablans, Martin, Rüthrich, Maria, Dolff, Sebastian, Wille, Kai, Haselberger, Martina, Heuzeroth, Hanno, Bode, Christoph, von zur Mühlen, Constantin, Rieg, Siegbert, and Duerschmied, Daniel

Published
2022
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32. COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation

Author

Reinscheid, Matthias, Luxenburger, Hendrik, Karl, Vivien, Graeser, Anne, Giese, Sebastian, Ciminski, Kevin, Reeg, David B., Oberhardt, Valerie, Roehlen, Natascha, Lang-Meli, Julia, Heim, Kathrin, Gross, Nina, Baum, Christina, Rieg, Siegbert, Speer, Claudius, Emmerich, Florian, Breisinger, Susanne, Steinmann, Daniel, Bengsch, Bertram, Boettler, Tobias, Kochs, Georg, Schwemmle, Martin, Thimme, Robert, Neumann-Haefelin, Christoph, and Hofmann, Maike

Published
2022
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33. In Which Patients Does the 2023 Duke-ISCVID Criteria for Infective Endocarditis Increase the Diagnosis of "Definite Endocarditis"?—A Preliminary Analysis in the Prospectively Evaluated DERIVE Cohort.

Author

Schmidt-Hellerau, Kirsten, Camp, Johannes, Marmulla, Philipp Alexander, Rieg, Siegbert, and Jung, Norma

Subjects
ENDOCARDITIS, DIAGNOSIS, VALVES, DEFINITIONS, MICROORGANISMS, INFECTIVE endocarditis
Abstract

Background/Objectives: Recently, an update of the Duke criteria for the diagnosis of infectious endocarditis has been published: the 2023 Duke-ISCVID criteria. To gain an insight into which proportion of patients are affected by the new criteria, and which criteria might be the most relevant for the expected increase in sensitivity, we analysed data from a registry of cardiovascular infections. Methods: The 2023 Duke-ISCVID criteria were applied to patients who were diagnosed with and treated for endocarditis after having been classified as "possible" endocarditis according to the 2015 ESC Modified Duke criteria. In patients thus newly classified as "definite endocarditis", diagnostic factors leading to this reclassification were described. Results: Of 397 patients, 48 (12%) did not fulfil the definition "definite infectious endocarditis" according to the 2015 ESC Modified Duke criteria. Of these, six (13%) fulfilled the definition when the 2023 Duke-ISCVID criteria were applied. A main factor triggering this reclassification was the consideration of microorganisms identified using valve PCR. Conclusions: As expected, the sensitivity of the new 2023 Duke-ISCVID criteria is increased in this cohort, mainly through the incorporation of new diagnostic methods in the criteria. Further studies are required to assess the effect on specificity in detail. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Antimicrobial resistance is not increasing in subsequent cases of ischaemic foot infections, a single‐centre cohort from 2012 to 2021.

Author

Salm, Jonas, Ikker, Franziska, Noory, Elias, Beschorner, Ulrich, Kramer, Tobias Siegfried, Rieg, Siegbert, Westermann, Dirk, and Zeller, Thomas

Subjects
ANTIBIOTICS, AMPUTATION, ISCHEMIA, DRUG resistance in microorganisms, RETROSPECTIVE studies, REVASCULARIZATION (Surgery), ENDOVASCULAR surgery, MULTIDRUG resistance, DESCRIPTIVE statistics, STAPHYLOCOCCUS aureus, LONGITUDINAL method, REINFECTION, FOOT diseases, DISEASE risk factors
Abstract

Patients with chronic limb‐threatening ischaemia (CLTI) are at risk of foot infections, which is associated with an increase in amputation rates. The use of antibiotics may lead to a higher incidence of antimicrobial resistance (AMR) in subsequent episodes of ischaemic foot infections (IFI). This retrospective single‐centre cohort study included 130 patients with IFI undergoing endovascular revascularisation. Staphylococcus aureus and Pseudomonas aeruginosa were the two most common pathogens, accounting for 20.5% and 10.8% of cases, respectively. The prevalence of antimicrobial resistance (AMR) and multi‐drug resistance did not significantly increase between episodes (10.2% vs. 13.4%, p = 0.42). In 59% of subsequent episodes, the identified pathogens were unrelated to the previous episode. However, the partial concordance of identified pathogens significantly increased to 66.7% when S. aureus was identified (p = 0.027). Subsequent episodes of IFI in the same patient are likely to differ in causative pathogens. However, in the case of S. aureus, the risk of reinfection, particularly with S. aureus, is increased. Multi‐drug resistance does not appear to change between IFI episodes. Therefore, recommendations for empirical antimicrobial therapy should be based on local pathogen and resistance statistics without the need to broaden the spectrum of antibiotics in subsequent episodes. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Machine Learning Based Prediction of COVID-19 Mortality Suggests Repositioning of Anticancer Drug for Treating Severe Cases

Author

Linden, Thomas, Hanses, Frank, Domingo-Fernández, Daniel, DeLong, Lauren Nicole, Kodamullil, Alpha Tom, Schneider, Jochen, Vehreschild, Maria J.G.T., Lanznaster, Julia, Ruethrich, Maria Madeleine, Borgmann, Stefan, Hower, Martin, Wille, Kai, Feldt, Torsten, Rieg, Siegbert, Hertenstein, Bernd, Wyen, Christoph, Roemmele, Christoph, Vehreschild, Jörg Janne, Jakob, Carolin E.M., Stecher, Melanie, Kuzikov, Maria, Zaliani, Andrea, and Fröhlich, Holger

Published
2021
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38. The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population—A comparison of two German registries

Author

Hasseli, Rebecca, primary, Hanses, Frank, additional, Stecher, Melanie, additional, Specker, Christof, additional, Weise, Tobias, additional, Borgmann, Stefan, additional, Hasselberger, Martina, additional, Hertenstein, Bernd, additional, Hower, Martin, additional, Hoyer, Bimba F., additional, Koll, Carolin, additional, Krause, Andreas, additional, von Lilienfeld-Toal, Marie, additional, Lorenz, Hanns-Martin, additional, Merle, Uta, additional, Nunes de Miranda, Susana M., additional, Pletz, Mathias W., additional, Regierer, Anne C., additional, Richter, Jutta G., additional, Rieg, Siegbert, additional, Roemmele, Christoph, additional, Ruethrich, Maria M., additional, Schmeiser, Tim, additional, Schulze-Koops, Hendrik, additional, Strangfeld, Anja, additional, Vehreschild, Maria J.G.T., additional, Voit, Florian, additional, Voll, Reinhard E., additional, Vehreschild, Jörg Janne, additional, Müller-Ladner, Ulf, additional, and Pfeil, Alexander, additional

Published
2024
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39. Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals – a prospectively evaluated multicentre cohort study from 2016-2020 of the R-Net study group

Author

Hornuss, Daniel, primary, Göpel, Siri, additional, Walker, Sarah V., additional, Tobys, David, additional, Häcker, Georg, additional, Seifert, Harald, additional, Higgins, Paul G., additional, Xanthopoulou, Kyriaki, additional, Gladstone, Beryl Primrose, additional, Cattaneo, Chiara, additional, Mischnik, Alexander, additional, Rohde, Anna M., additional, Imirzalioglu, Can, additional, Trauth, Janina, additional, Fritzenwanker, Moritz, additional, Falgenhauer, Jane, additional, Gastmeier, Petra, additional, Behnke, Michael, additional, Kramme, Evelyn, additional, Käding, Nadja, additional, Rupp, Jan, additional, Peter, Silke, additional, Schmauder, Kristina, additional, Eisenbeis, Simone, additional, Kern, Winfried V., additional, Tacconelli, Evelina, additional, and Rieg, Siegbert, additional

Published
2024
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40. Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial

Author

Kaasch, Achim J, primary, López-Cortés, Luis Eduardo, additional, Rodríguez-Baño, Jesús, additional, Cisneros, José Miguel, additional, Dolores Navarro, M, additional, Fätkenheuer, Gerd, additional, Jung, Norma, additional, Rieg, Siegbert, additional, Lepeule, Raphaël, additional, Coutte, Laetitia, additional, Bernard, Louis, additional, Lemaignen, Adrien, additional, Kösters, Katrin, additional, MacKenzie, Colin R, additional, Soriano, Alex, additional, Hagel, Stefan, additional, Fantin, Bruno, additional, Lafaurie, Matthieu, additional, Talarmin, Jean-Philippe, additional, Dinh, Aurélien, additional, Guimard, Thomas, additional, Boutoille, David, additional, Welte, Tobias, additional, Reuter, Stefan, additional, Kluytmans, Jan, additional, Martin, Maria Luisa, additional, Forestier, Emmanuel, additional, Stocker, Hartmut, additional, Vitrat, Virginie, additional, Tattevin, Pierre, additional, Rommerskirchen, Anna, additional, Noret, Marion, additional, Adams, Anne, additional, Kern, Winfried V, additional, Hellmich, Martin, additional, Seifert, Harald, additional, Valiente, Adoración, additional, de Cueto, Marina, additional, Rodríguez, Ángel, additional, Molina, José, additional, Fischer, Julia, additional, Paul, Gregor, additional, Gallien, Sébastien, additional, Fihman, Vincent, additional, Lacasse, Marion, additional, Coustillères, Francois, additional, Becker, Christian, additional, Fuchs, André, additional, Morata, Laura, additional, Weis, Sebastian, additional, Ponscarme, Diane, additional, Khatchatourian, Lydie, additional, Rouveix, Elisabeth, additional, Merrien, Dominique, additional, Lecomte, Raphaël, additional, Veenemans, Jacobien, additional, Vilchez, Helem H., additional, Kessel, Johanna, additional, Bonten, Marc J.M., additional, Rupp, Jan, additional, Hocqueloux, Laurent, additional, Lucht, Frederic, additional, Stahl, Jean-Paul, additional, Vlek, Anne, additional, Prinz-Langenohl, Reinhild, additional, and Tolsma, Violaine, additional

Published
2024
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41. Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine

Author

Oberhardt, Valerie, Luxenburger, Hendrik, Kemming, Janine, Schulien, Isabel, Ciminski, Kevin, Giese, Sebastian, Csernalabics, Benedikt, Lang-Meli, Julia, Janowska, Iga, Staniek, Julian, Wild, Katharina, Basho, Kristi, Marinescu, Mircea Stefan, Fuchs, Jonas, Topfstedt, Fernando, Janda, Ales, Sogukpinar, Oezlem, Hilger, Hanna, Stete, Katarina, Emmerich, Florian, Bengsch, Bertram, Waller, Cornelius F., Rieg, Siegbert, Sagar, Boettler, Tobias, Zoldan, Katharina, Kochs, Georg, Schwemmle, Martin, Rizzi, Marta, Thimme, Robert, Neumann-Haefelin, Christoph, and Hofmann, Maike

Published
2021
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42. Characterization of pre-existing and induced SARS-CoV-2-specific CD8.sup.+ T cells

Author

Schulien, Isabel, Kemming, Janine, Oberhardt, Valerie, Wild, Katharina, Seidel, Lea M., Killmer, Saskia, Daul, Franziska, Lago, Marilyn Salvat, Decker, Annegrit, Luxenburger, Hendrik, Binder, Benedikt, Bettinger, Dominik, Sogukpinar, Oezlem, Rieg, Siegbert, Panning, Marcus, Huzly, Daniela, Schwemmle, Martin, Kochs, Georg, Waller, Cornelius F., Nieters, Alexandra, Duerschmied, Daniel, Emmerich, Florian, Mei, Henrik E., Schulz, Axel Ronald, Llewellyn-Lacey, Sian, Price, David A., Boettler, Tobias, Bengsch, Bertram, Thimme, Robert, Hofmann, Maike, and Neumann-Haefelin, Christoph

Subjects
T cells -- Physiological aspects, Biological sciences, Health
Abstract

Emerging data indicate that SARS-CoV-2-specific CD8.sup.+ T cells targeting different viral proteins are detectable in up to 70% of convalescent individuals.sup.1-5. However, very little information is currently available about the abundance, phenotype, functional capacity and fate of pre-existing and induced SARS-CoV-2-specific CD8.sup.+ T cell responses during the natural course of SARS-CoV-2 infection. Here, we define a set of optimal and dominant SARS-CoV-2-specific CD8.sup.+ T cell epitopes. We also perform a high-resolution ex vivo analysis of pre-existing and induced SARS-CoV-2-specific CD8.sup.+ T cells, applying peptide-loaded major histocompatibility complex class I (pMHCI) tetramer technology. We observe rapid induction, prolonged contraction and emergence of heterogeneous and functionally competent cross-reactive and induced memory CD8.sup.+ T cell responses in cross-sectionally analyzed individuals with mild disease following SARS-CoV-2 infection and three individuals longitudinally assessed for their T cells pre- and post-SARS-CoV-2 infection. SARS-CoV-2-specific memory CD8.sup.+ T cells exhibited functional characteristics comparable to influenza-specific CD8.sup.+ T cells and were detectable in SARS-CoV-2 convalescent individuals who were seronegative for anti-SARS-CoV-2 antibodies targeting spike (S) and nucleoprotein (N). These results define cross-reactive and induced SARS-CoV-2-specific CD8.sup.+ T cell responses as potentially important determinants of immune protection in mild SARS-CoV-2 infection. Functionally competent memory CD8.sup.+ T cells specific for different viral epitopes are induced by SARS-CoV-2 infection and can be detected in the absence of virus-specific antibodies., Author(s): Isabel Schulien [sup.1] , Janine Kemming [sup.1] [sup.2] , Valerie Oberhardt [sup.1] [sup.2] , Katharina Wild [sup.1] [sup.3] , Lea M. Seidel [sup.1] [sup.2] [sup.4] [sup.5] , Saskia Killmer [...]

Published
2021
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43. Increasing numbers and complexity of Staphylococcus aureus bloodstream infection—14 years of prospective evaluation at a German tertiary care centre with multi-centre validation of findings

Author

Bader, Barisch, Blum, Yannic, Buhl, Michael, Cattaneo, Chiara, Dinkelacker, Ariane Gertraud, Gladstone, Beryl Primerose, Kleipaß, Matthias, Lenke, Dana, Olawumi-Hurter, Sara Christina, Diaz, Luis Alberto Peña, Pilarski, Georg, Proske, Susanna, Thoma, Norbert, Mathé, Philipp, Göpel, Siri, Hornuss, Daniel, Tobys, David, Käding, Nadja, Eisenbeis, Simone, Kohlmorgen, Britta, Trauth, Janina, Gölz, Hanna, Walker, Sarah V., Mischnik, Alexander, Peter, Silke, Hölzl, Florian, Rohde, Anna M., Behnke, Michael, Fritzenwanker, Moritz, Häcker, Georg, Steffens, Benedict, Vehreschild, Maria, Kramme, Evelyn, Falgenhauer, Jane, Peyerl-Hoffmann, Gabriele, Seifert, Harald, Rupp, Jan, Gastmeier, Petra, Imirzalioglu, Can, Tacconelli, Evelina, Kern, Winfried, and Rieg, Siegbert

Published
2023
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44. Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study

Author

Kuehl, Richard, Morata, Laura, Boeing, Christian, Subirana, Isaac, Seifert, Harald, Rieg, Siegbert, Kern, Winfried V., Kim, Hong Bin, Kim, Eu Suk, Liao, Chun-Hsing, Tilley, Robert, Lopez-Cortés, Luis Eduardo, Llewelyn, Martin J., Fowler, Vance G., Thwaites, Guy, Cisneros, José Miguel, Scarborough, Matt, Nsutebu, Emmanuel, Gurgui Ferrer, Mercedes, Pérez, José L., Barlow, Gavin, Hopkins, Susan, Ternavasio-de la Vega, Hugo Guillermo, Török, Estée, Wilson, Peter, Kaasch, Achim J., Soriano, Alex, Bernasch, Christian, Jung, Norma, Lamarca Soria, Karuna, Rivera Martínez, Maria Alba, Prim, Nuria, Martínez, José Antonio, Marcos, Miguel, Baño, Jesús Rodríguez, De Cueto, Marina, Sung, Kyoung-Ho, Kim, Chung-Jong, Kang, Chang Kyung, Park, Jung In, Morris-Jones, Stephen, Kamfose, Musa, Young, Bernadette, Gott, Hannah, Gouliouris, Theodore, Bedford, Luke, Price, James, Kern, Winfried V, Llewelyn, Martin J, Fowler, Vance G, Pérez, José L, Török, M Estée, and Kaasch, Achim J

Published
2020
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45. First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”

Author

Jakob, Carolin E. M., Borgmann, Stefan, Duygu, Fazilet, Behrends, Uta, Hower, Martin, Merle, Uta, Friedrichs, Anette, Tometten, Lukas, Hanses, Frank, Jung, Norma, Rieg, Siegbert, Wille, Kai, Grüner, Beate, Klinker, Hartwig, Gersbacher-Runge, Nicole, Hellwig, Kerstin, Eberwein, Lukas, Dolff, Sebastian, Rauschning, Dominic, von Bergwelt-Baildon, Michael, Lanznaster, Julia, Strauß, Richard, Trauth, Janina, de With, Katja, Ruethrich, Maria, Lueck, Catherina, Nattermann, Jacob, Tscharntke, Lene, Pilgram, Lisa, Fuhrmann, Sandra, Classen, Annika, Stecher, Melanie, Schons, Maximilian, Spinner, Christoph, and Vehreschild, Jörg Janne

Published
2021
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46. Health care utilisation of asylum seekers and refugees in the South-West of Germany.

Author

Bockey, Annabelle J., Braun, Cornelia, Camp, Johannes, Janda, Aleš, Kern, Winfried V., Müller, Anne-Maria, Stete, Katarina, Rieg, Siegbert R., and Lange, Berit

Subjects
MEDICAL care use, RIGHT of asylum, POLITICAL refugees, TIME series analysis, HEALTH services accessibility, CLINICS
Abstract

Background: Limited evidence on utilisation of health care by recently arrived asylum seekers and refugees in high-income countries is available. This study aims to describe the implementation of an integrated care facility (ICF) in an initial reception centre and measure the utilisation of care and the influence of operational parameters. Methods: In a retrospective cohort study design, using medical records, we followed inhabitants of a reception centre in Germany between 11.10.2015 and 30.05.2018. We assessed frequency of visits and revisits to a newly established integrated care facility (ICF), and the effects of the ICF on visits to the local emergency department (LED) in the regional tertiary hospital using survival analysis and time series regression. We also explore the influence of operational parameters on the different implementation phases; phase 1: provisional clinic with 1–2 hours of physician presence daily, phase 2: implementation of ICF with 2–4 hours of care by a team of doctors and nurses daily, phase 3: routine running of ICF with daily operational hours of 10am–2pm with care provided by an interdisciplinary team of doctors and nurses. Results: 14,419 total medical visits were recorded from 1,883 persons seeking health care in the ICF. The absolute number of visits per day remained similar over the study period (19·9/day), yet the relative number of visits changed from 2·2 to 15 per 100 inhabitants from phase 2 to 3, respectively. Most visits were due to respiratory infections (612/3080, 20%), and trauma and musculoskeletal conditions (441/3080, 14%). The rate of revisits to ICF was 2·9 per person per month (95%CI 2·9–3), more for those older, female, from North Africa and those with a translator present. The ratio of visits to the LED changed from 0·3/100 inhabitants per day to 0·14/100 inhabitants after implementation of the ICF and back to 0·3/100 inhabitants during the routine running. Conclusions: Though seasonal variation and referral practices must be considered, a high rate of revisits to the ICF were recorded. While visits to the LED decreased after the implementation of the ICF, visits returned to the pre-ICF levels during the routine running of the ICF. The results show that AS&R require reliable access to health care, yet the needs of specific groups of migrants may be different, especially those with language barriers, minority groups or those from certain regions. As such, care should be migrant sensitive and adapt to the changing needs of the population. Though more research is required to better understand the differing needs of migrants, this study may help to inform guidelines surrounding migrant sensitive standards of care in Germany. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Vaccination protects against acute respiratory distress syndrome (ARDS) in hospitalized patients with COVID-19

Author

Madrid, Julian, primary, Agarwal, Prerana, additional, Müller-Peltzer, Katharina, additional, Askani, Marvin, additional, Benning, Leo, additional, Selig, Mischa, additional, Diehl, Philipp, additional, Kalbhenn, Johannes, additional, Trummer, Georg, additional, Utzolino, Stefan, additional, Wengenmeyer, Tobias, additional, Busch, Hans-Jörg, additional, Stolz, Daiana, additional, Rieg, Siegbert, additional, Panning, Marcus, additional, Schlett, Christopher L., additional, Bamberg, Fabian, additional, and Askani, Esther, additional

Published
2023
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49. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium

Author

Sperotto, Francesca, primary, Gutiérrez-Sacristán, Alba, additional, Makwana, Simran, additional, Li, Xiudi, additional, Rofeberg, Valerie N., additional, Cai, Tianxi, additional, Bourgeois, Florence T., additional, Omenn, Gilbert S., additional, Hanauer, David A., additional, Sáez, Carlos, additional, Bonzel, Clara-Lea, additional, Bucholz, Emily, additional, Dionne, Audrey, additional, Elias, Matthew D., additional, García-Barrio, Noelia, additional, González, Tomás González, additional, Issitt, Richard W., additional, Kernan, Kate F., additional, Laird-Gion, Jessica, additional, Maidlow, Sarah E., additional, Mandl, Kenneth D., additional, Ahooyi, Taha Mohseni, additional, Moraleda, Cinta, additional, Morris, Michele, additional, Moshal, Karyn L., additional, Pedrera-Jiménez, Miguel, additional, Shah, Mohsin A., additional, South, Andrew M., additional, Spiridou, Anastasia, additional, Taylor, Deanne M., additional, Verdy, Guillaume, additional, Visweswaran, Shyam, additional, Wang, Xuan, additional, Xia, Zongqi, additional, Zachariasse, Joany M., additional, Newburger, Jane W., additional, Avillach, Paul, additional, Aaron, James R., additional, Adam, Atif, additional, Agapito, Giuseppe, additional, Albayrak, Adem, additional, Albi, Giuseppe, additional, Alessiani, Mario, additional, Alloni, Anna, additional, Amendola, Danilo F., additional, Angoulvant, François, additional, Anthony, Li LLJ., additional, Aronow, Bruce J., additional, Ashraf, Fatima, additional, Atz, Andrew, additional, Panickan, Vidul Ayakulangara, additional, Azevedo, Paula S., additional, Badenes, Rafael, additional, Balshi, James, additional, Batugo, Ashley, additional, Beaulieu-Jones, Brendin R., additional, Beaulieu-Jones, Brett K., additional, Bell, Douglas S., additional, Bellasi, Antonio, additional, Bellazzi, Riccardo, additional, Benoit, Vincent, additional, Beraghi, Michele, additional, Bernal-Sobrino, José Luis, additional, Bernaux, Mélodie, additional, Bey, Romain, additional, Bhatnagar, Surbhi, additional, Blanco-Martínez, Alvar, additional, Boeker, Martin, additional, Booth, John, additional, Bosari, Silvano, additional, Bradford, Robert L., additional, Brat, Gabriel A., additional, Bréant, Stéphane, additional, Brown, Nicholas W., additional, Bruno, Raffaele, additional, Bryant, William A., additional, Bucalo, Mauro, additional, Burgun, Anita, additional, Cannataro, Mario, additional, Carmona, Aldo, additional, Cattelan, Anna Maria, additional, Caucheteux, Charlotte, additional, Champ, Julien, additional, Chen, Jin, additional, Chen, Krista Y., additional, Chiovato, Luca, additional, Chiudinelli, Lorenzo, additional, Cho, Kelly, additional, Cimino, James J., additional, Colicchio, Tiago K., additional, Cormont, Sylvie, additional, Cossin, Sébastien, additional, Craig, Jean B., additional, Cruz-Bermúdez, Juan Luis, additional, Cruz-Rojo, Jaime, additional, Dagliati, Arianna, additional, Daniar, Mohamad, additional, Daniel, Christel, additional, Das, Priyam, additional, Devkota, Batsal, additional, Duan, Rui, additional, Dubiel, Julien, additional, DuVall, Scott L., additional, Esteve, Loic, additional, Estiri, Hossein, additional, Fan, Shirley, additional, Follett, Robert W., additional, Ganslandt, Thomas, additional, Garmire, Lana X., additional, Gehlenborg, Nils, additional, Getzen, Emily J., additional, Geva, Alon, additional, Goh, Rachel SJ., additional, Gradinger, Tobias, additional, Gramfort, Alexandre, additional, Griffier, Romain, additional, Griffon, Nicolas, additional, Grisel, Olivier, additional, Guzzi, Pietro H., additional, Han, Larry, additional, Haverkamp, Christian, additional, Hazard, Derek Y., additional, He, Bing, additional, Henderson, Darren W., additional, Hilka, Martin, additional, Ho, Yuk-Lam, additional, Holmes, John H., additional, Honerlaw, Jacqueline P., additional, Hong, Chuan, additional, Huling, Kenneth M., additional, Hutch, Meghan R., additional, Jannot, Anne Sophie, additional, Jouhet, Vianney, additional, Kainth, Mundeep K., additional, Kate, Kernan F., additional, Kavuluru, Ramakanth, additional, Keller, Mark S., additional, Kennedy, Chris J., additional, Key, Daniel A., additional, Kirchoff, Katie, additional, Klann, Jeffrey G., additional, Kohane, Isaac S., additional, Krantz, Ian D., additional, Kraska, Detlef, additional, Krishnamurthy, Ashok K., additional, L'Yi, Sehi, additional, Leblanc, Judith, additional, Lemaitre, Guillaume, additional, Lenert, Leslie, additional, Leprovost, Damien, additional, Liu, Molei, additional, Will Loh, Ne Hooi, additional, Long, Qi, additional, Lozano-Zahonero, Sara, additional, Luo, Yuan, additional, Lynch, Kristine E., additional, Mahmood, Sadiqa, additional, Makoudjou, Adeline, additional, Malovini, Alberto, additional, Mao, Chengsheng, additional, Maram, Anupama, additional, Maripuri, Monika, additional, Martel, Patricia, additional, Martins, Marcelo R., additional, Marwaha, Jayson S., additional, Masino, Aaron J., additional, Mazzitelli, Maria, additional, Mazzotti, Diego R., additional, Mensch, Arthur, additional, Milano, Marianna, additional, Minicucci, Marcos F., additional, Moal, Bertrand, additional, Moore, Jason H., additional, Morris, Jeffrey S., additional, Mousavi, Sajad, additional, Mowery, Danielle L., additional, Murad, Douglas A., additional, Murphy, Shawn N., additional, Naughton, Thomas P., additional, Breda Neto, Carlos Tadeu, additional, Neuraz, Antoine, additional, Newburger, Jane, additional, Ngiam, Kee Yuan, additional, Njoroge, Wanjiku FM., additional, Norman, James B., additional, Obeid, Jihad, additional, Okoshi, Marina P., additional, Olson, Karen L., additional, Orlova, Nina, additional, Ostasiewski, Brian D., additional, Palmer, Nathan P., additional, Paris, Nicolas, additional, Patel, Lav P., additional, Pfaff, Ashley C., additional, Pfaff, Emily R., additional, Pillion, Danielle, additional, Pizzimenti, Sara, additional, Priya, Tanu, additional, Prokosch, Hans U., additional, 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2023
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