222 results on '"Rietzschel, E"'
Search Results
2. Lipid management in patients with high and very high cardiovascular risk: Data from routine clinical practice in Europe (SANTORINI study)
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Ray, K., primary, Aguiar, C., additional, Arca, M., additional, Connolly, D., additional, Eriksson, M., additional, Ferrieres, J., additional, Laufs, U., additional, Mostaza, J., additional, Nanchen, D., additional, Blackburn, C., additional, Soronen, J., additional, Lamparter, M., additional, Rietzschel, E., additional, Strandberg, T., additional, Toplak, H., additional, Visseren, F., additional, and Catapano, A., additional
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- 2023
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3. Ethnic-Specific Normative Reference Values for Echocardiographic LA and LV Size, LV Mass, and Systolic Function: The EchoNoRMAL Study
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Poppe, K.K., Doughty, R.N., Gardin, J.M., Hobbs, F.D.R., McMurray, J.J.V., Nagueh, S.F., Senior, R., Thomas, L., Whalley, G.A., Aune, E., Brown, A., Badano, L.P., Cameron, V., Chadha, D.S., Chahal, N., Chien, K.L., Daimon, M., Dalen, H., Detrano, R., Akif Duzenli, M., Ezekowitz, J., de Simone, G., Di Pasquale, P., Fukuda, S., Gill, P.S., Grossman, E., Kim, H.-K., Kuznetsova, T., Leung, N.K.W., Linhart, A., McDonagh, T.A., McGrady, M., Mill, J.G., Mogelvang, R., Muiesan, M.L., Ng, A.C.T., Ojji, D., Otterstad, J.E., Petrovic, D.J., Prendergast, B., Rietzschel, E., Schirmer, H., Schvartzman, P., Simova, I., Sliwa, K., Stewart, S., Squire, I.B., Takeuchi, M., Altman, D.G., Perera, R., Triggs, C.M., Au Yeung, H., Beans Picón, G.A., Anderson, T., Dyck, J., Ezekowitz, J.A., Chirinos, J.A., De Buyzere, M.L., Gillebert, T.C., Segers, P., Van daele, C.M., Walsh, H.A., Izzo, R., De Luca, N., Trimarco, B., Goel, K., Misra, A., Chen, P.-C., Lin, H.-J., Su, T.-C., Richards, A.M., Troughton, R., Skov Jensen, J., Paterna, S., Davies, M.K., Davis, R.C., Roalfe, A., Calvert, M., Freemantle, N., Lip, G.Y.H., Staessen, J.A., Dargie, H.J., Ford, I., Galasko, G., Lahiri, A., Carrington, M., Krum, H., Zeitz, C., Blauwet, L., Moelmen Hansen, H.E., Støylen, A., Thorstensen, A., Watanabe, H., Yoshikawa, J., Chambers, J.C., Kooner, J., Davies, J., Loke, I., Ng, L., Leung, D.Y., Arnold, L., Coffey, S., d'Arcy, J., Hammond, C., Mabbett, C., Lima, C., Loudon, M., Pinheiro, N., Reynolds, R., Muraru, D., Peluso, D., Dal Bianco, L., Petrovic, J., Fuchs, F.D., Katova, T., Kaku, K., Boyd, A., Chia, E.M., Angelo, L.C., Pereira, A.C., Krieger, J.E., Rodrigues, S.L., Paini, A., Agabiti Rosei, E., and Salvetti, M.
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- 2015
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4. Relation Between Left Ventricular Relaxation Rate and Arterial Loading
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Claessens, Tom, Rietzschel, E. R., De Buyzere, M. L., De Bacquer, D., De Backer, G., Gillebert, T. C., Verdonck, P. R., Segers, P., Magjarevic, R., editor, Nagel, J. H., editor, Vander Sloten, Jos, editor, Verdonck, Pascal, editor, Nyssen, Marc, editor, and Haueisen, Jens, editor
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- 2009
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5. Factors associated with clinical inertia: an integrative review
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Aujoulat I, Jacquemin P, Rietzschel E, Scheen A, Tréfois P, Wens J, Darras E, and Hermans MP
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Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Isabelle Aujoulat,1 Patricia Jacquemin,1 Ernst Rietzschel,2 André Scheen,3 Patrick Tréfois,4 Johan Wens,5 Elisabeth Darras,1 Michel P Hermans6 1Université Catholique de Louvain, Institute of Health and Society, Brussels, 2Ghent University, Department of Cardiovascular Diseases and Department of Public Health, Faculty of Medicine and Health Sciences, Ghent, 3University of Liège, Division of Diabetes, Nutrition and Metabolic Disorders and Clinical Pharmacology Unit, CHU Liège, Liège, 4Société Scientifique de Médecine Générale, Brussels, 5University of Antwerp, Faculty of Medicine and Health Sciences, Primary and Interdisciplinary Care Antwerp, 6Université Catholique de Louvain, Institute of Experimental and Clinical Research and Cliniques Universitaires Saint-Luc, Department of Endocrinology and Nutrition, Brussels, Belgium Abstract: Failure to initiate or intensify therapy according to evidence-based guidelines is increasingly being acknowledged as a phenomenon that contributes to inadequate management of chronic conditions, and is referred to as clinical inertia. However, the number and complexity of factors associated with the clinical reasoning that underlies the decision-making processes in medicine calls for a critical examination of the consistency of the concept. Indeed, in the absence of information on and justification of treatment decisions that were made, clinical inertia may be only apparent, and actually reflect good clinical practice. This integrative review seeks to address the factors generally associated with clinical inaction, in order to better delineate the concept of true clinical inertia. Keywords: clinical inertia, evidence-based medicine, clinical decision, integrative review, concept clarification, physician adherence to guidelines
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- 2014
6. Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization
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Descamps, O.S., Tenoutasse, S., Stephenne, X., Gies, I., Beauloye, V., Lebrethon, M.-C., De Beaufort, C., De Waele, K., Scheen, A., Rietzschel, E., Mangano, A., Panier, J.P., Ducobu, J., Langlois, M., Balligand, J.-L., Legat, P., Blaton, V., Muls, E., Van Gaal, L., Sokal, E., Rooman, R., Carpentier, Y., De Backer, G., and Heller, F.R.
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- 2011
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7. The relationship between diet and subclinical atherosclerosis: results from the Asklepios Study
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Hoebeeck, L I, Rietzschel, E R, Langlois, M, De Buyzere, M, De Bacquer, D, De Backer, G, Maes, L, Gillebert, T, and Huybrechts, I
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- 2011
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8. MODERATED POSTER SESSION: Diseases impact on left ventricular function: Friday 5 December 2014, 08: 30–18: 00Location: Moderated Poster area
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Gillebert, T C, Chirinos, J A, Rietzschel, E R, Shiva-Kumar, P, De Buyzere, M L, Zamani, P, Claessens, T C, Akers, S R, De Bacquer, D, and Segers, P
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- 2014
9. Poster session 3: Thursday 4 December 2014, 14: 00–18: 00Location: Poster area
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Gillebert, T C, Chirinos, J A, Claessens, T C, Raja, M W, De Buyzere, M L, Segers, P, and Rietzschel, E R
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- 2014
10. A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study
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Doughty, R. N., Gardin, J. M., Hobbs, F. D. R., McMurray, J. J. V., Nagueh, S. F., Poppe, K. K., Senior, R., Thomas, L., Whalley, G. A., Aune, E., Brown, A., Badano, L. P., Cameron, V., Chadha, D. S., Chahal, N., Chien, K. L., Daimon, M., Dalen, H., Detrano, R., Akif Duzenli, M., Ezekowitz, J., de Simone, G., Di Pasquale, P., Fukuda, S., Gill, P. S., Grossman, E., Hobbs, F. D. R., Kim, H. –K., Kuznetsova, T., Leung, N. K. W., Linhart, A., McDonagh, T. A., McGrady, M., McMurray, J. J. V., Mill, J. G., Mogelvang, R., Muiesan, M. L., Ng, A. C. T., Ojji, D., Otterstad, J. E., Petrovic, D. J., Poppe, K. K., Prendergast, B., Rietzschel, E., Schirmer, H., Schvartzman, P., Senior, R., Simova, I., Sliwa, K., Stewart, S., Squire, I. B., Takeuchi, M., Thomas, L., Whalley, G. A., Altman, D., Perera, R., Poppe, K. K., Triggs, C. M., Au Yeung, H., Beans Picón, G. A., Poppe, K. K., and Whalley, G. A.
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- 2014
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11. The reservoir pressure concept: the 3-element windkessel model revisited? Application to the Asklepios population study
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Vermeersch, S. J., Rietzschel, E. R., De Buyzere, M. L., Van Bortel, L. M., Gillebert, T. C., Verdonck, P. R., and Segers, P.
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- 2009
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12. What creative cognition and goal interrelations have in common? Personality as a common predictor
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Wronska, M. K., Rietzschel, E. F., Nijstad, B. A., Organizational Psychology, and SOM OB
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- 2020
13. Evaluation of contemporary treatment of high- and very high-risk patients for the prevention of cardiovascular events in Europe:methodology and rationale for the multinational observational SANTORINI study
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Ray, K. K. (Kausik K.), Haq, I. (Inaam), Bilitou, A. (Aikaterini), Aguiar, C. (Carlos), Arca, M. (Marcello), Connolly, D. L. (Derek L), Eriksson, M. (Mats), Ferrières, J. (Jean), Hildebrandt, P. (Per), Laufs, U. (Ulrich), Mostaza, J. M. (Jose M.), Nanchen, D. (David), Rietzschel, E. (Ernst), Strandberg, T. (Timo), Toplak, H. (Hermann), Visseren, F. L. (Frank L. J.), Catapano, A. L. (Alberico L.), Ray, K. K. (Kausik K.), Haq, I. (Inaam), Bilitou, A. (Aikaterini), Aguiar, C. (Carlos), Arca, M. (Marcello), Connolly, D. L. (Derek L), Eriksson, M. (Mats), Ferrières, J. (Jean), Hildebrandt, P. (Per), Laufs, U. (Ulrich), Mostaza, J. M. (Jose M.), Nanchen, D. (David), Rietzschel, E. (Ernst), Strandberg, T. (Timo), Toplak, H. (Hermann), Visseren, F. L. (Frank L. J.), and Catapano, A. L. (Alberico L.)
- Abstract
Background and aims: Clinical practice before 2019 suggests a substantial proportion of high and very high CV risk patients taking lipid-lowering therapy (LLT) would not achieve the new LDL-C goals recommended in the 2019 ESC/EAS guidelines (<70 and <55 mg/dL, respectively). To what extent practice has changed since the last ESC/EAS guideline update is uncertain, and quantification of remaining implementation gaps may inform health policy. Methods: The SANTORINI study is a multinational, multicentre, prospective, observational, non-interventional study documenting patient data at baseline (enrolment) and at 12-month follow-up. The study recruited 9606 patients ≥18 years of age with high and very high CV risk (as assigned by the investigators) requiring LLT, with no formal patient or comparator groups. The primary objective is to document, in the real-world setting, the effectiveness of current treatment modalities in managing plasma levels of LDL-C in high- and very high-risk patients requiring LLT. Key secondary effectiveness objectives include documenting the relationship between LLT and levels of other plasma lipids, high-sensitivity C-reactive protein (hsCRP) and overall predicted CV risk over one year. Health economics and patient-relevant parameters will also be assessed. Conclusions: The SANTORINI study, which commenced after the 2019 ESC/EAS guidelines were published, is ideally placed to provide important contemporary insights into the evolving management of LLT in Europe and highlight factors contributing to the low levels of LDL-C goal achievement among high and very high CV risk patients. It is hoped the findings will help enhance patient management and reduce the burden of ASCVD in Europe.
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- 2021
14. Sex differences in the association between arterial hypertension, blood pressure and sleep apnea in the general population
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Bauters, F, primary, Hertegonne, K, additional, Pevernagie, D, additional, De Buyzere, M, additional, Chirinos, J, additional, and Rietzschel, E, additional
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- 2021
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15. Modest opposite associations of endogenous testosterone and oestradiol with left ventricular remodelling and function in healthy middle-aged men
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Ruige, J. B., Rietzschel, E. R., De Buyzere, M. L., Bekaert, S., Segers, P., De Bacquer, D., De Backer, G., Gillebert, T. C, and Kaufman, J. M.
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- 2011
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16. Effects of a single dose of cocoa flavanols on blood pressure in patients with type 2 diabetes compared to healthy people
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Tanghe, A., primary, Heyman, E., additional, Shadid, S., additional, Rietzschel, E., additional, Lespagnol, E., additional, Celie, B., additional, and Calders, P., additional
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- 2020
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17. Validation of a new automated IMT measurement algorithm
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Vermeersch, S J, Rietzschel, E R, De Buyzere, M L, Van Bortel, L M, D'Asseler, Y, Gillebert, T C, Verdonck, P R, and Segers, P
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- 2007
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18. Influence and interference of isosorbide dinitrate and food intake on superior mesenteric artery impedance in humans
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De Buyzere, M., Rietzschel, E., Duprez, D., Voet, D., Mareels, S., and Afschrift, M.
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- 1995
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19. Abnormal Aortic Wall Properties in Women with Turner Syndrome
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Bons, Lidia, Hoven, Allard, Malik, Maira, van den Bosch, Annemien, Mcghie, Jackie, Duijnhouwer, Anthonie, Siebelink, H-MJ, Hirsch, Alexander, Devos, D, Rietzschel, E, von der Thüsen, Jan, De Graaf - van de Laar, Ingrid, Verhagen, Judith, van der Pluijm, Ingrid, Budde, Ricardo, Roos - Hesselink, Jolien, Bons, Lidia, Hoven, Allard, Malik, Maira, van den Bosch, Annemien, Mcghie, Jackie, Duijnhouwer, Anthonie, Siebelink, H-MJ, Hirsch, Alexander, Devos, D, Rietzschel, E, von der Thüsen, Jan, De Graaf - van de Laar, Ingrid, Verhagen, Judith, van der Pluijm, Ingrid, Budde, Ricardo, and Roos - Hesselink, Jolien
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- 2020
20. P10.1 Arterial Stiffness and the “Phenotype” Metabolic Syndrome: A Cross-Country Study. The Mare Consortium
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Scuteri, A., Cunha, P., Cockroft, J., Cucca, F., Laurent, S., Raso, F., Muiesan, M., Rietzschel, E., Ryliskyte, L., Vlachopoulos, C., Nilsson, P., and Lakatta, E.
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- 2014
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21. 620 Normalized stroke volume in severe aortic stenosis with preserved ejection fraction: reference values and outcome implications
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Bohbot, Y, primary, Rusinaru, D, additional, Rietzschel, E, additional, De Buyzere, M, additional, Buicuic, O, additional, Marechaux, S, additional, Gilebert, T, additional, and Tribouilloy, T, additional
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- 2020
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22. Normalized stroke volume in severe aortic stenosis with preserved ejection fraction: Reference values and outcome implications
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Rusinaru, D., primary, Bohbot, Y., additional, Rietzschel, E., additional, De Buyzere, M., additional, Buiciuc, O., additional, Maréchaux, S., additional, Gilebert, T., additional, and Tribouilloy, C., additional
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- 2019
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23. A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study
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Anderson T., Dyck J., Ezekowitz J. A., Chirinos J. A., De Buyzere M. L., Gillebert T. C., Rietzschel E., Segers P., Van Daele C. M., Doughty R. N., Poppe K. K., Walsh H. A., Whalley G. A., Chen P. C., Chien K. L., Lin H. J., Su, T. C., Mogelvang R., Jensen J. S., Chadha D. S., Goel K., Misra A., Detrano R., Cameron V., Richards A. M., Troughton R., Di Pasquale P., Paterna S., Duzenli M. A., Hobbs F. D. R., Davies M. K., Davis R. C., Roalfe A., Calvert M., Freemantle N., Gill, P. S., Lip G. Y. H., Kuznetsova T., Staessen J. A., Dargie H. J., Ford I., McDonagh T. A., McMurray J. J. V., Grossman E., Galasko G., Lahiri A., Senior R., Blauwet L., Sliwa K., Stewart S., Brown A., Carrington M., Krum H., McGrady M., Zeitz C., Dalen H., Hansen H. E. M., Støylen A., Thorstensen A., Daimon M., Watanabe H., Yoshikawa J., Fukuda S., Kim H. K., Leung N. K. W., Linhart A., Chahal N., Chambers J. C., Kooner J., Davies J., Loke I., Ng, L., Squire I. B., Aune E., Otterstad J. E., Leung D. Y., Ng A. C. T., Ojji D., Arnold L., Coffey S., D'Arcy J., Hammond C., Mabbett C., Lima C., Loudon M., Pinheiro N., Prendergast B., Reynolds R., Badano L. P., Muraru D., Peluso D., Dal Bianco L., Petrovic D. J., Petrovic J., Schvartzman P., Fuchs F. D., Katova T., Simova I., Kaku K., Takeuchi M., Boyd A., Thomas L., Chia E. M., Schirmer H., Angelo L. C., Pereira A. C., Krieger J. E., Mill J. G., Rodrigues S. L., Muiesan M. L., Paini A., Rosei E. A., Salvetti M., Gardin J. M., Nagueh S. F., Altman D., Perera R., Triggs C. M., Au Yeung H., Beans Picon G. A., IZZO, RAFFAELE, DE LUCA, NICOLA, TRIMARCO, BRUNO, DE SIMONE, GIOVANNI, Anderson, T., Dyck, J., Ezekowitz, J. A., Chirinos, J. A., De Buyzere, M. L., Gillebert, T. C., Rietzschel, E., Segers, P., Van Daele, C. M., Doughty, R. N., Poppe, K. K., Walsh, H. A., Whalley, G. A., Izzo, Raffaele, DE LUCA, Nicola, Trimarco, Bruno, DE SIMONE, Giovanni, Chen, P. C., Chien, K. L., Lin, H. J., Su, T. C., Mogelvang, R., Jensen, J. S., Chadha, D. S., Goel, K., Misra, A., Detrano, R., Cameron, V., Richards, A. M., Troughton, R., Di Pasquale, P., Paterna, S., Duzenli, M. A., Hobbs, F. D. R., Davies, M. K., Davis, R. C., Roalfe, A., Calvert, M., Freemantle, N., Gill, P. S., Lip, G. Y. H., Kuznetsova, T., Staessen, J. A., Dargie, H. J., Ford, I., Mcdonagh, T. A., Mcmurray, J. J. V., Grossman, E., Galasko, G., Lahiri, A., Senior, R., Blauwet, L., Sliwa, K., Stewart, S., Brown, A., Carrington, M., Krum, H., Mcgrady, M., Zeitz, C., Dalen, H., Hansen, H. E. M., Støylen, A., Thorstensen, A., Daimon, M., Watanabe, H., Yoshikawa, J., Fukuda, S., Kim, H. K., Leung, N. K. W., Linhart, A., Chahal, N., Chambers, J. C., Kooner, J., Davies, J., Loke, I., Ng, L., Squire, I. B., Aune, E., Otterstad, J. E., Leung, D. Y., Ng, A. C. T., Ojji, D., Arnold, L., Coffey, S., D'Arcy, J., Hammond, C., Mabbett, C., Lima, C., Loudon, M., Pinheiro, N., Prendergast, B., Reynolds, R., Badano, L. P., Muraru, D., Peluso, D., Dal Bianco, L., Petrovic, D. J., Petrovic, J., Schvartzman, P., Fuchs, F. D., Katova, T., Simova, I., Kaku, K., Takeuchi, M., Boyd, A., Thomas, L., Chia, E. M., Schirmer, H., Angelo, L. C., Pereira, A. C., Krieger, J. E., Mill, J. G., Rodrigues, S. L., Muiesan, M. L., Paini, A., Rosei, E. A., Salvetti, M., Gardin, J. M., Nagueh, S. F., Altman, D., Perera, R., Triggs, C. M., Au Yeung, H., Beans Picon, G. A., and Badano, L
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Male ,Pediatrics ,International Cooperation ,Left ,Ethnic Group ,Sex Factor ,Ventricular Function, Left ,Heart Ventricle ,Cohort Studies ,Echocardiography ,Meta-analysis ,Reference ranges ,Adolescent ,Adult ,Age Factors ,Aged ,Aged, 80 and over ,Atrial Function, Left ,Ethnic Groups ,Female ,Heart Atria ,Heart Ventricles ,Humans ,Middle Aged ,Reference Standards ,Sex Factors ,Young Adult ,Cardiology and Cardiovascular Medicine ,Radiology, Nuclear Medicine and Imaging ,Nuclear Medicine and Imaging ,80 and over ,Ethnicity ,Ventricular Function ,Age Factor ,Young adult ,education.field_of_study ,General Medicine ,Atrial Function ,Parametric Regression Method ,Cohort ,Cardiology ,Radiology ,Human ,Cohort study ,medicine.medical_specialty ,Population ,Internal medicine ,medicine ,Meta-analysi ,Radiology, Nuclear Medicine and imaging ,education ,business.industry ,Reference range ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Quantile regression ,Reference Standard ,Normative ,Cohort Studie ,business - Abstract
Aim: To develop age-, sex-, and ethnic-Appropriate normative reference ranges for standard echocardiographic measurements of the left heart by combining echocardiographic measurements obtained from adult volunteers without clinical cardiovascular disease or significant cardiovascular risk factors, from multiple studies around the world.Methods and results: The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) collaboration was established and population-based data sets of echocardiographic measurements combined to perform an individual person data meta-Analysis. Data from 43 studies were received, representing 51 222 subjects, of which 22 404 adults aged 18-80 years were without clinical cardiovascular or renal disease, hypertension or diabetes. Quantile regression or an appropriate parametric regression method will be used to derive reference values at the 5th and 95th centile of each measurement against age. Conclusion: This unique data set represents a large, multi-ethnic cohort of subjects resident in a wide range of countries. The resultant reference ranges will have wide applicability for normative data based on age, sex, and ethnicity. © The Author 2013.
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- 2013
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24. Evolocumab and clinical outcomes in patients with cardiovascular disease
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Sabatine, Marc S., Giugliano, Robert P., Keech, Anthony C., Honarpour, Narimon, Wiviott, Stephen D., Murphy, Sabina A., Kuder, Julia F., Wang, Huei, Liu, Thomas, Wasserman, Scott M., Sever, Peter S., Pedersen, Fish MP, Terje R., Abrahamsen, Te, Im, K, Kanevsky, E, Bonaca, Mp, Lira Pineda, A, Hanlon, K, Knusel, B, Somaratne, R, Kurtz, C, Scott, R, Accini Mendoza JL, Amerena, J, Badariene, J, Burgess, L, Ceska, R, Charng, Mj, Choi, D, Cobos, Jl, Dan, Ga, De Ferrari GM, Deedwania, Pc, Chopra, Vk, Erglis, A, Ezhov, Mv, Ferreira, J, Filipová, S, Gaciong, Za, Pasierski, T, Georgiev, Bg, Gonzalez-Galvez, G, Gouni-Berthold, I, Schäufele, T, Hirayama, A, Huber, K, Rammer, M, Kjaerulf Jensen, H, Wermuth, S, Jiang, L, Jukema, Jw, Kraydashenko, O, Leiter, La, Lewis, Bs, López-Miranda, J, Lorenzatti, Aj, Mach, F, Mcadam, B, Nilsson, L, Olsson, Å, Rallidis, L, Rogelio, Gg, Kerr Saraiva JF, Scheen, A, Schiele, F, Scott, Rs, Connolly, D, Siu, Cw, Tay, L, Thorgeirsson, G, Tikkanen, Mj, Tokgozoglu, Sl, Toth, K, Viigimaa, M, Wan Ahmad WA, Hennekens, Ch, Andreotti, F, Baigent, C, Brown, Wv, Davis, Br, Newcomer, Jw, Wood, Sk, Larosa, J, Ansell, B, Olsson, A, Lowe, C, Zahn, L, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Mackinnon, I, Vogel, Dr, Leon de la Fuente, R, Perna, E, Amuchastegui, M, Pacora, F, Hershson, A, Blumberg, E, Glenny, Ja, Colombo, H, Cuadrado, Ja, Nicolosi, L, Rojas, Cg, Ulla, Mr, Hasbani, Eg, Cuneo, C, Lopez Santi RG, Sanabria, Hd, Hrabar, A, Lozada, A, Begg, A, Lehman, S, Wittert, G, Juergens, C, Kostner, K, Beltrame, J, Simpson, R, Sinhal, A, Adams, M, Kritharides, L, Roberts Thomson, P, Cross, D, Thompson, P, Van Gaal, W, Cox, N, Farshid, A, Hammett, C, Garrahy, P, Prasan, A, Horrigan, M, Ebenbichler, C, Hanusch, U, Prager, R, Schernthaner, G, Luger, A, Siostrzonek, P, Toplak, H, Bergler-Klein, J, Paulweber, B, Sinzinger, H, Buysschaert, I, Thoeng, J, 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Tahirkheli, N, Delgado, E, Derian, W, Greenwald, J, Harris, M, Jackson, R, Marhefka, G, Mcelveen, W, Mooss, A, Morris, P, Murray, J, Pearlstein, P, Raisinghani, A, Rezkalla, S, Sakhrani, L, Schreibman, D, Shaoulian, E, Steinsapir, J, Yataco, A, De La Cruz, A, Fredrick, M, Goldenberg, E, Lee, D, Mccullum, K, Mclellan, B, Stephens, L, Wilson, S, Alfieri, A, Mandviwala, M, Orourke, D, Samal, A, Schmedtje, J, Waxman, F, Carhart, R, Clements, B, Dyke, C, Ghali, J, Gruberg, L, Hack, T, Jehle, A, Pogue, B, Schooley, C, and Shifrin, G
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Male ,STATIN THERAPY ,2700 General Medicine ,Disease ,Cardiovascular ,PLACEBO-CONTROLLED TRIAL ,Gastroenterology ,0302 clinical medicine ,Anticholesteremic Agent ,Medicine ,Myocardial infarction ,11 Medical and Health Sciences ,ddc:616 ,Incidence ,Antibodies, Monoclonal ,General Medicine ,Cholesterol ,Cardiovascular Diseases ,Monoclonal ,Drug Therapy, Combination ,Proprotein Convertase 9 ,Antibody ,Aged ,Anticholesteremic Agents ,Atherosclerosis ,Cholesterol, LDL ,Double-Blind Method ,Female ,Follow-Up Studies ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Hypercholesterolemia ,Least-Squares Analysis ,Middle Aged ,Medicine (all) ,REDUCING LIPIDS ,Human ,medicine.medical_specialty ,Evinacumab ,Clinical Trials and Supportive Activities ,PCSK9 INHIBITION ,Follow-Up Studie ,LDL ,03 medical and health sciences ,Drug Therapy ,Clinical Research ,LDL-C ,Least-Squares Analysi ,Science & Technology ,Unstable angina ,PCSK9 ,medicine.disease ,chemistry ,Clinical Biochemistry ,030204 cardiovascular system & hematology ,Bococizumab ,FOURIER Steering Committee and Investigators ,Medical and Health Sciences ,chemistry.chemical_compound ,Antibodies monoclonal ,Cardiovascular Disease ,030212 general & internal medicine ,Stroke ,Humanized ,RISK ,biology ,PCSK9 Inhibitors ,10051 Rheumatology Clinic and Institute of Physical Medicine ,Heart Disease ,Atherosclerosi ,6.1 Pharmaceuticals ,Combination ,Cardiology ,Life Sciences & Biomedicine ,Antibodies, Monoclonal, Humanized ,EZETIMIBE ,610 Medicine & health ,Antibodies ,Medicine, General & Internal ,General & Internal Medicine ,Internal medicine ,CORONARY-HEART-DISEASE ,In patient ,Heart Disease - Coronary Heart Disease ,Alirocumab ,Ldl cholesterol ,business.industry ,Evaluation of treatments and therapeutic interventions ,Evolocumab ,Good Health and Well Being ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,biology.protein ,MODERATE ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business - Abstract
Background Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin–kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. Methods We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. Results At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P
- Published
- 2017
25. Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
- Author
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Vallejo-Vaz, A.J. Marco, M.D. Stevens, C.A.T. Akram, A. Freiberger, T. Hovingh, G.K. Kastelein, J.J.P. Mata, P. Raal, F.J. Santos, R.D. Soran, H. Watts, G.F. Abifadel, M. Aguilar-Salinas, C.A. Al-Khnifsawi, M. Alkindi, F.A. Alnouri, F. Alonso, R. Al-Rasadi, K. Al-Sarraf, A. Ashavaid, T.F. Binder, C.J. Bogsrud, M.P. Bourbon, M. Bruckert, E. Chlebus, K. Corral, P. Descamps, O. Durst, R. Ezhov, M. Fras, Z. Genest, J. Groselj, U. Harada-Shiba, M. Kayikcioglu, M. Lalic, K. Lam, C.S.P. Latkovskis, G. Laufs, U. Liberopoulos, E. Lin, J. Maher, V. Majano, N. Marais, A.D. März, W. Mirrakhimov, E. Miserez, A.R. Mitchenko, O. Nawawi, H.M. Nordestgaard, B.G. Paragh, G. Petrulioniene, Z. Pojskic, B. Postadzhiyan, A. Reda, A. Reiner, Ž. Sadoh, W.E. Sahebkar, A. Shehab, A. Shek, A.B. Stoll, M. Su, T.-C. Subramaniam, T. Susekov, A.V. Symeonides, P. Tilney, M. Tomlinson, B. Truong, T.-H. Tselepis, A.D. Tybjærg-Hansen, A. Vázquez-Cárdenas, A. Viigimaa, M. Vohnout, B. Widén, E. Yamashita, S. Banach, M. Gaita, D. Jiang, L. Nilsson, L. Santos, L.E. Schunkert, H. Tokgözoğlu, L. Car, J. Catapano, A.L. Ray, K.K. Schreier, L. Pang, J. Dieplinger, H. Hanauer-Mader, G. Desutter, J. Langlois, M. Mertens, A. Rietzschel, E. Wallemacq, C. Isakovic, D. Dzankovic, A.M. Obralija, J. Pojskic, L. Sisic, I. Stimjanin, E. Torlak, V.A. Jannes, C.E. Krieger, J.E. Pereira, A.C. Ruel, I. Asenjo, S. Cuevas, A. Pećin, I. Miltiadous, G. Panayiotou, A.G. Vrablik, M. Benn, M. Heinsar, S. Béliard, S. Gouni-Berthold, I. Hengstenberg, W. Julius, U. Kassner, U. Klose, G. König, C. König, W. Otte, B. Parhofer, K. Schatz, U. Schmidt, N. Steinhagen-Thiessen, E. Vogt, A. Antza, C. Athyros, V. Bilianou, E. Boufidou, A. Chrousos, G. Elisaf, M. Garoufi, A. Katsiki, N. Kolovou, G. Kotsis, V. Rallidis, L. Rizos, C. Skalidis, E. Skoumas, I. Tziomalos, K. Shawney, J.P.S. Abbaszadegan, M.R. Aminzadeh, M. Hosseini, S. Mobini, M. Vakili, R. Zaeri, H. Agar, R. Boran, G. Colwell, N. Crowley, V. Durkin, M. Griffin, D. Kelly, M. Rakovac-Tisdall, A. Bitzur, R. Cohen, H. Eliav, O. Ellis, A. Gavish, D. Harats, D. Henkin, Y. Knobler, H. Leavit, L. Leitersdorf, E. Schurr, D. Shpitzen, S. Szalat, A. Arca, M. Averna, M. Bertolini, S. Calandra, S. Tarugi, P. Erglis, A. Gilis, D. Nesterovics, G. Saripo, V. Upena-Roze, A. Elbitar, S. Jambart, S. Khoury, P.E. Gargalskaite, U. Kutkiene, S. Al-Khateeb, A. An, C.Y. Ismail, Z. Kasim, S. Ibrahim, K.S. Radzi, A.B.M. Kasim, N.A. Nor, N.S.M. Ramli, A.S. Razak, S.A. Muid, S. Rosman, A. Sanusi, A.R. Razman, A.Z. Nazli, S.A. Kek, T.L. Azzopardi, C. Aguilar Salinas, C.A. Galán, G. Rubinstein, A. Magaña-Torres, M.T. Martagon, A. Mehta, R. Wittekoek, M.E. Isara, A.R. Obaseki, D.E. Ohenhen, O.A. Holven, K.B. Gruchała, M. Baranowska, M. Borowiec-Wolny, J. Gilis-Malinowska, N. Michalska-Grzonkowska, A. Pajkowski, M. Parczewska, A. Romanowska-Kocejko, M. Stróżyk, A. Żarczyńska-Buchowiecka, M. Kleinschmidt, M. Alves, A.C. Medeiros, A.M. Ershova, A. Korneva, V. Kuznetsova, T. Malyshev, P. Meshkov, A. Rozhkova, T. Popovic, L. Lukac, S.S. Stosic, L. Rasulic, I. Lalic, N.M. Chua, T.S.J. Ting, S.P.L. Raslova, K. Battelino, T. Cevc, M. Jug, B. Kovac, J. Podkrajsek, K.T. Sustar, U. Trontelj, K.J. Marais, D. Isla, L.P. Martin, F.J. Charng, M.-J. Chen, P.-L. Kayikçioglu, M. Dell’oca, N. Fernández, G. Ressia, A. Reyes, X. Zelarayan, M. Alieva, R.B. Hoshimov, S.U. Nizamov, U.I. Kurbanov, R.D. Lima-Martínez, M.M. Nguyen, M.-N.T. Do, D.-L. Kim, N.-T. Le, T.-T. Le, H.-A.
- Abstract
Background and aims: Management of familial hypercholesterolaemia (FH) may vary across different settings due to factors related to population characteristics, practice, resources and/or policies. We conducted a survey among the worldwide network of EAS FHSC Lead Investigators to provide an overview of FH status in different countries. Methods: Lead Investigators from countries formally involved in the EAS FHSC by mid-May 2018 were invited to provide a brief report on FH status in their countries, including available information, programmes, initiatives, and management. Results: 63 countries provided reports. Data on FH prevalence are lacking in most countries. Where available, data tend to align with recent estimates, suggesting a higher frequency than that traditionally considered. Low rates of FH detection are reported across all regions. National registries and education programmes to improve FH awareness/knowledge are a recognised priority, but funding is often lacking. In most countries, diagnosis primarily relies on the Dutch Lipid Clinics Network criteria. Although available in many countries, genetic testing is not widely implemented (frequent cost issues). There are only a few national official government programmes for FH. Under-treatment is an issue. FH therapy is not universally reimbursed. PCSK9-inhibitors are available in ∼2/3 countries. Lipoprotein-apheresis is offered in ∼60% countries, although access is limited. Conclusions: FH is a recognised public health concern. Management varies widely across countries, with overall suboptimal identification and under-treatment. Efforts and initiatives to improve FH knowledge and management are underway, including development of national registries, but support, particularly from health authorities, and better funding are greatly needed. © 2018 Elsevier B.V.
- Published
- 2018
26. Arterial stiffness and influences of the metabolic syndrome: A cross-countries study
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Scuteri, A., Cunha, P. G., AGABITI ROSEI, Enrico, Badariere, J., Bekaert, S., Cockcroft, J. R., Cotter, J., Cucca, F., M. L., De, Meyer, T. D., Ferrucci, L., Franco, O., Gale, N., Gillebert, T. C., Langlois, M., Laucevicius, A., Laurent, S., F. U. S., Morrell, C. H., Muiesan, Maria Lorenza, Munnery, M. M., Navickas, R., Oliveira, P., Orru', M., Pilia, M. G., Rietzschel, E. R., Ryliskyte, L., Salvetti, Massimo, Schlessinger, D., Sousa, N., Stefanadis, C., Strait, J., Daele, C. V., Villa, I., Vlachopoulos, C., Witteman, J., Xaplanteris, P., Nilsson, P., Lakatta, E. G., Hofman, A., M. A. R., Universidade do Minho, Epidemiology, and Internal Medicine
- Subjects
Male ,Comorbidity ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Pulse wave velocity ,Abdominal obesity ,Metabolic Syndrome ,education.field_of_study ,arterial stiffness, metabolic syndrome, aortic stiffness ,Anthropometry ,Smoking ,Middle Aged ,Arterial stiffness ,Metabolic syndrome ,3. Good health ,Europe ,Hypertension ,Cohort ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,aortic stiffness ,Population ,Pulse Wave Analysis ,Article ,03 medical and health sciences ,Sex Factors ,Vascular Stiffness ,SDG 3 - Good Health and Well-being ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Humans ,Cross-cultural comparison ,Risk factor ,education ,Aged ,Dyslipidemias ,Science & Technology ,business.industry ,medicine.disease ,United States ,Cross-Sectional Studies ,Endocrinology ,business - Abstract
Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in >= 3 of the 5 components: abdominal obesity (W), high triglycerides (T), low HDL cholesterol (H), elevated blood pressure (B), and elevated fasting glucose (G). PWV measured in each cohort was "normalized" to account for different acquisition methods. MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components - even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus - in all the MARE cohorts. In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV). (C) 2014 Elsevier Ireland Ltd. All rights reserved., NIH -National Institutes of Health
- Published
- 2014
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27. P3.01: Effect of Body Side on Atherosclerotic Plaque Distribution in the Carotid and Femoral Arteries
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Bossuyt, J., De Buyzere, M., Van daele, C., De Backer, T., Van Bortel, L., and Rietzschel, E.
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- 2013
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28. P3.25: The Effect of Diastolic Asymptotic Pressure on the Reservoir Pressure in Human
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Borlotti, A., Vermeersch, S., Rietzschel, E. R., Segers, P., and Khir, A. W.
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- 2013
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29. One-year experience with monoclonal antibodies against PCSK9 in belgian patients with familial hypercholesterolemia
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De Fays, C., primary, Persu, A., additional, Beauloye, C., additional, Balligand, J.L., additional, Wallemacq, C., additional, Rietzschel, E., additional, Vanoverschelde, J.L., additional, and Descamps, O.S., additional
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- 2018
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30. P2.04 Pulse Wave Velocity and Wave Intensity in the Carotid Artery of Healthy Human: Windkessel and Windkessel-Less Analysis
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Borlotti, A., Vermeersch, S., Rietzschel, E. R., De Buyzere, M. L., Segers, P., and Khir, A. W.
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- 2012
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31. Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
- Author
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Vallejo-Vaz, A.J. Marco, M.D. Stevens, C.A.T. Akram, A. Freiberger, T. Hovingh, G.K. Kastelein, J.J.P. Mata, P. Raal, F.J. Santos, R.D. Soran, H. Watts, G.F. Abifadel, M. Aguilar-Salinas, C.A. Al-Khnifsawi, M. Alkindi, F.A. Alnouri, F. Alonso, R. Al-Rasadi, K. Al-Sarraf, A. Ashavaid, T.F. Binder, C.J. Bogsrud, M.P. Bourbon, M. Bruckert, E. Chlebus, K. Corral, P. Descamps, O. Durst, R. Ezhov, M. Fras, Z. Genest, J. Groselj, U. Harada-Shiba, M. Kayikcioglu, M. Lalic, K. Lam, C.S.P. Latkovskis, G. Laufs, U. Liberopoulos, E. Lin, J. Maher, V. Majano, N. Marais, A.D. März, W. Mirrakhimov, E. Miserez, A.R. Mitchenko, O. Nawawi, H.M. Nordestgaard, B.G. Paragh, G. Petrulioniene, Z. Pojskic, B. Postadzhiyan, A. Reda, A. Reiner, Ž. Sadoh, W.E. Sahebkar, A. Shehab, A. Shek, A.B. Stoll, M. Su, T.-C. Subramaniam, T. Susekov, A.V. Symeonides, P. Tilney, M. Tomlinson, B. Truong, T.-H. Tselepis, A.D. Tybjærg-Hansen, A. Vázquez-Cárdenas, A. Viigimaa, M. Vohnout, B. Widén, E. Yamashita, S. Banach, M. Gaita, D. Jiang, L. Nilsson, L. Santos, L.E. Schunkert, H. Tokgözoğlu, L. Car, J. Catapano, A.L. Ray, K.K. Schreier, L. Pang, J. Dieplinger, H. Hanauer-Mader, G. Desutter, J. Langlois, M. Mertens, A. Rietzschel, E. Wallemacq, C. Isakovic, D. Dzankovic, A.M. Obralija, J. Pojskic, L. Sisic, I. Stimjanin, E. Torlak, V.A. Jannes, C.E. Krieger, J.E. Pereira, A.C. Ruel, I. Asenjo, S. Cuevas, A. Pećin, I. Miltiadous, G. Panayiotou, A.G. Vrablik, M. Benn, M. Heinsar, S. Béliard, S. Gouni-Berthold, I. Hengstenberg, W. Julius, U. Kassner, U. Klose, G. König, C. König, W. Otte, B. Parhofer, K. Schatz, U. Schmidt, N. Steinhagen-Thiessen, E. Vogt, A. Antza, C. Athyros, V. Bilianou, E. Boufidou, A. Chrousos, G. Elisaf, M. Garoufi, A. Katsiki, N. Kolovou, G. Kotsis, V. Rallidis, L. Rizos, C. Skalidis, E. Skoumas, I. Tziomalos, K. Shawney, J.P.S. Abbaszadegan, M.R. Aminzadeh, M. Hosseini, S. Mobini, M. Vakili, R. Zaeri, H. Agar, R. Boran, G. Colwell, N. Crowley, V. Durkin, M. Griffin, D. Kelly, M. Rakov and Vallejo-Vaz, A.J. Marco, M.D. Stevens, C.A.T. Akram, A. Freiberger, T. Hovingh, G.K. Kastelein, J.J.P. Mata, P. Raal, F.J. Santos, R.D. Soran, H. Watts, G.F. Abifadel, M. Aguilar-Salinas, C.A. Al-Khnifsawi, M. Alkindi, F.A. Alnouri, F. Alonso, R. Al-Rasadi, K. Al-Sarraf, A. Ashavaid, T.F. Binder, C.J. Bogsrud, M.P. Bourbon, M. Bruckert, E. Chlebus, K. Corral, P. Descamps, O. Durst, R. Ezhov, M. Fras, Z. Genest, J. Groselj, U. Harada-Shiba, M. Kayikcioglu, M. Lalic, K. Lam, C.S.P. Latkovskis, G. Laufs, U. Liberopoulos, E. Lin, J. Maher, V. Majano, N. Marais, A.D. März, W. Mirrakhimov, E. Miserez, A.R. Mitchenko, O. Nawawi, H.M. Nordestgaard, B.G. Paragh, G. Petrulioniene, Z. Pojskic, B. Postadzhiyan, A. Reda, A. Reiner, Ž. Sadoh, W.E. Sahebkar, A. Shehab, A. Shek, A.B. Stoll, M. Su, T.-C. Subramaniam, T. Susekov, A.V. Symeonides, P. Tilney, M. Tomlinson, B. Truong, T.-H. Tselepis, A.D. Tybjærg-Hansen, A. Vázquez-Cárdenas, A. Viigimaa, M. Vohnout, B. Widén, E. Yamashita, S. Banach, M. Gaita, D. Jiang, L. Nilsson, L. Santos, L.E. Schunkert, H. Tokgözoğlu, L. Car, J. Catapano, A.L. Ray, K.K. Schreier, L. Pang, J. Dieplinger, H. Hanauer-Mader, G. Desutter, J. Langlois, M. Mertens, A. Rietzschel, E. Wallemacq, C. Isakovic, D. Dzankovic, A.M. Obralija, J. Pojskic, L. Sisic, I. Stimjanin, E. Torlak, V.A. Jannes, C.E. Krieger, J.E. Pereira, A.C. Ruel, I. Asenjo, S. Cuevas, A. Pećin, I. Miltiadous, G. Panayiotou, A.G. Vrablik, M. Benn, M. Heinsar, S. Béliard, S. Gouni-Berthold, I. Hengstenberg, W. Julius, U. Kassner, U. Klose, G. König, C. König, W. Otte, B. Parhofer, K. Schatz, U. Schmidt, N. Steinhagen-Thiessen, E. Vogt, A. Antza, C. Athyros, V. Bilianou, E. Boufidou, A. Chrousos, G. Elisaf, M. Garoufi, A. Katsiki, N. Kolovou, G. Kotsis, V. Rallidis, L. Rizos, C. Skalidis, E. Skoumas, I. Tziomalos, K. Shawney, J.P.S. Abbaszadegan, M.R. Aminzadeh, M. Hosseini, S. Mobini, M. Vakili, R. Zaeri, H. Agar, R. Boran, G. Colwell, N. Crowley, V. Durkin, M. Griffin, D. Kelly, M. Rakov
- Abstract
Background and aims: Management of familial hypercholesterolaemia (FH) may vary across different settings due to factors related to population characteristics, practice, resources and/or policies. We conducted a survey among the worldwide network of EAS FHSC Lead Investigators to provide an overview of FH status in different countries. Methods: Lead Investigators from countries formally involved in the EAS FHSC by mid-May 2018 were invited to provide a brief report on FH status in their countries, including available information, programmes, initiatives, and management. Results: 63 countries provided reports. Data on FH prevalence are lacking in most countries. Where available, data tend to align with recent estimates, suggesting a higher frequency than that traditionally considered. Low rates of FH detection are reported across all regions. National registries and education programmes to improve FH awareness/knowledge are a recognised priority, but funding is often lacking. In most countries, diagnosis primarily relies on the Dutch Lipid Clinics Network criteria. Although available in many countries, genetic testing is not widely implemented (frequent cost issues). There are only a few national official government programmes for FH. Under-treatment is an issue. FH therapy is not universally reimbursed. PCSK9-inhibitors are available in ∼2/3 countries. Lipoprotein-apheresis is offered in ∼60% countries, although access is limited. Conclusions: FH is a recognised public health concern. Management varies widely across countries, with overall suboptimal identification and under-treatment. Efforts and initiatives to improve FH knowledge and management are underway, including development of national registries, but support, particularly from health authorities, and better funding are greatly needed. © 2018 Elsevier B.V.
- Published
- 2018
32. P6.16: Determination of Carotid and Femoral Wave Speed and Distensibility in A Healthy Population Using A New Non-Invasive Technique
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Borlotti, A., Vermeersch, S., Rietzschel, E., Segers, P., and Khir, A. W.
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- 2011
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33. P11.07 Difference Between Systolic and Diastolic Carotid Artery Stiffness is Independently Associated with Left Ventricular Mass Index in Healthy Middle-Aged Subjects
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Reesink, K. D., Hermeling, E., Vermeersch, S. J., Rietzschel, E. R., De Buyzere, M. L., Gillebert, T., van de Laar, R. J., Ferreira, I., Hoeks, A. P. G., van Bortel, L. M., Reneman, R. S., and Segers, P.
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- 2010
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34. 5.6 Quantification of Both Systolic and Diastolic Local Arterial Stiffness Improves Identification of Arterial Stiffening With Normal Aging
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Reesink, K., Hermeling, E., Vermeersch, S., Rietzschel, E., De Buyzere, M., Reneman, R. S., Hoeks, A. P. G., and Segers, P.
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- 2009
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35. P1.38 Conversion Between Definitions of Pulse Wave Velocity
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Vermeersch, S. J., Rietzschel, E., Gillebert, T. C., Laurent, S., Boutouyrie, P., and Segers, P.
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- 2008
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36. 07.06 Long Term Oral Contraceptive use is an Independent Risk Factor for Arterial Stiffening
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Rietzschel, E. R., De Buyzere, M. L., Segers, P., Bekaert, S., De Bacquer, D., De Backer, G. G., and Gillebert, T. C.
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- 2008
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37. 03.05 Estimated Central Blood Pressure: Importance of Radial Artery Pressure Waveform Calibration
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Mahieu, D., Rietzschel, E. R., De Buyzere, M. L., Verbeke, F., Gillebert, T. C., De Backer, G., De Bacquer, D., Verdonck, P., Van Bortel, L. M., and Segers, P.
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- 2008
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38. P2.23 The Reservoir Pressure Concept: The 3-Element Windkessel Model Revisited? Application to the Asklepios Population Study
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Vermeersch, S. J., Rietzschel, E., De Buyzere, M. L., De Backer, D., De Bacquer, G., Van Bortel, L. M., Gillebert, T. C., Verdonck, P. R., and Segers, P.
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- 2008
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39. 06.07 Evaluation of a Method of Wave Reflection Assessment Via Triangular Flow Wave Approximation
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Kips, J. G., Rietzschel, E. R., De Buyzere, M. L., Gillebert, T. C., Van Bortel, L. M., and Segers, P.
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- 2007
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40. P.055 Common Carotid Artery Stiffness: More Sensitive to Age and Gender Related Large Artery Stiffening than Aortic Pulse Wave Velocity?
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Vermeersch, S. J., Rietzschel, E. R., De Buyzere, M. L., De Bacquer, D., De Backer, G., Van Bortel, L. M., Gillebert, T. C., Verdonck, P. R., and Segers, P.
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- 2007
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41. P.081 Validity of the One-Third Rule to Calculate Mean Arterial Pressure
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Mahieu, D., Rietzschel, E., De Buyzere, M., Gillebert, T., Segers, P., and Van Bortel, L
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- 2007
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42. P.073 Integrated Arterial System Analysis in a Population of Healthy Middle-Aged Men and Women: Augmentation Index Versus Wave Reflection Indices
- Author
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Segers, P., Rietzschel, E. R., De Buyzere, M. L., Vermeersch, S. J., De Bacquer, D., Van Bortel, L. M., De Backer, G., Gillebert, T. C., and Verdonck, P. R.
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- 2006
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43. A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension
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Olsen M, Angell S, Asma S, Boutouyrie P, Burger D, Chirinos J, Damasceno A, Delles C, Gimenez-Roqueplo A, Hering D, Lopez-Jaramillo P, Martinez F, Perkovic V, Rietzschel E, Schillaci G, Schutte A, Scuteri A, Sharman J, Wachtell K, and Wang J
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- 2016
44. MR Pulse Wave Velocity Increases With Age Faster in the Thoracic Aorta Than in the Abdominal Aorta
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Devos, D.G.H., Rietzschel, E., Heyse, C., Vandemaele, P., Bortel, L. van, Babin, D., Segers, P., Westenberg, J.M., and Achten, R.
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arterial stiffness ,thoracic aorta ,pulse wave velocity ,aging ,abdominal aorta - Published
- 2015
45. Evolocumab and clinical outcomes in patients with cardiovascular disease
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H., Desire, A., Hershon, K., Napoli, M., Tami, L., Rothschild, R., Khurana, S., Gupta, D., Cheung, D., Hearne, S., Grubb, S., Miller, A., Baird, I., Marcus, A., Srivastava, S., Forgosh, L., Fritz, R., Mays, M., Bertolet, B., Reddy, J., Khan, M., Nakhle, S., Dill, S., Fishbein, G., Khan, B., Marais, H., Reschak, M., Malone, M., Nadar, V., Whitney, R., Reichman, A., Reyes, H., El Shahawy, M., Rabinowitz, A., Weinstein, D., Farhat, N., Onyema, D., Potu, R., Runquist, L., Barnum, O., Crater, T., Fialkow, J., Shah, A., Thompson, C., Wiseman, A., Doyle, T., Henderson, D., Herzog, W., Schnitzler, R., Carr, K., Davis, M., Nagajothi, N., Olsen, S., Rogers, W., Rubino, J., Singh, I., Tarleton, G., Bhagwat, R., Clardy, D., Jardula, M., Robinson, J., Torres, M., Vijay, N., Farris, N., Lillo, J., Moriarty, P., Recknor, C., Berlacher, P., Christensen, T., Gabra, N., Issa, M., Janik, M., Lawless, A., Molter, D., Stout, E., Brezina, B., Claxton, E., Linsky, R., Poock, J., Remler, R., Roseman, H., Schramm, E., Al-Joundi, T., Amin, J., Hitchcock, J., Isserman, S., Kirstein, J., Rider, J., Shalek, M., Sherman, H., Bernstein, M., Chandra, L., Hatharasinghe, R., Ibrahim, H., Iteld, B., Linzmeyer, K., Seaton, B., Zeig, S., Christofides, E., Dunbar, R., Griffin, S., Kohli, N., Koren, M., Pharr, W., Purdy, D., Spencer, R., Yeoman, G., Banerjee, S., Cheek, H. B., Engel, E., Hamroff, G., Huling, R., Kozlowski, L., Levin, P., Makam, S., Meengs, M., Bhushan, R., Erickson, B., Herman, L., Lo, E., Mcdowell, E., Mcgrew, F., Miller, M., Ord, J., Webel, R., Wilhoit, G., Wise, J., Yang, E., Budoff, M., Collins, J., Dauber, I., Dobkin, L., Focil, A., Gandy, W., Pasquini, J., Ramos, M., Rodriguez, D., Rosenson, R., Sanford, K., Schlau, A., Snyder, B., Stonesifer, L., Tang, A., De Souza, J., Elam, M., French, J., Guyton, J., Hage Korban, E., Kereiakes, D., King, M., Loh, I., Navarro, J., Simons, R., Tobin, T., Younis, L., Aboufakher, R., Baldari, D., Ballantyne, C., Broughton, R., Eaton, C., Johnston, J., Simon, W., Thomson, S., Vora, K., Youngman, D., Alzohaili, O., Auerbach, E., Brown, C., Burrough, B., Chen, Y., Gilpatrick, M., Landzberg, J., Mitchell, C., Rice, L., Rubenfire, M., Sofley, C. W., Strobl, D., Atassi, K., Davila, W., Diogo, J., Fagan, T., Joffe, I., Krishna, J., Osea, E., Penny, W., Rowe, W., Shapiro, M., Welker, J., Benton, R., Dobratz, D., Fortuin, F., Graham, J., Henry, B., Kusnick, B., Lutskiy, M., Mcrae, A., Saway, W., Scott, J., Shah, M., Weinberg, B., Zarich, S., Acheatel, R., Case, C., Earl, J., Fernandez, S., Giugliano, G., Handelsman, Y., Hermany, P., Holder, S., Kashyap, M., Khan, A., Lader, E., Peniston, J., Raoof, T., Sacco, J., Shore, K., Spriggs, D., Stringam, S., Tahirkheli, N., Delgado, E., Derian, W., Greenwald, J., Harris, M., Jackson, R., Marhefka, G., Mcelveen, W., Mooss, A., Morris, P., Murray, J., Pearlstein, P., Raisinghani, A., Rezkalla, S., Sakhrani, L., Schreibman, D., Shaoulian, E., Steinsapir, J., Yataco, A., De La Cruz, A., Fredrick, M., Goldenberg, E., Lee, D., Mccullum, K., Mclellan, B., Stephens, L., Wilson, S., Alfieri, A., Mandviwala, M., Orourke, D., Samal, A., Schmedtje, J., Waxman, F., Carhart, R., Clements, B., Dyke, C., Ghali, J., Gruberg, L., Hack, T., Jehle, A., Pogue, B., Schooley, C., Shifrin, G., and Biasucci L. M. (ORCID:0000-0002-6921-6497)
- Abstract
BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reacti
- Published
- 2017
46. Ethnic-specific normative reference values for echocardiographic la and LV size, LV mass, and systolic function: The EchoNoRMAL study
- Author
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Poppe, K. K., Doughty, R. N., Gardin, J. M., Nagueh, S. F., Whalley, G. A., Cameron, V., Chadha, D. S., Chien, K. L., Detrano, R., Akif Duzenli, M., Ezekowitz, J., Di Pasquale, P., Mogelvang, R., Altman, D. G., Perera, R., Triggs, C. M., Au Yeung, H., Beans Picon, G. A., Anderson, T., Dyck, J., Ezekowitz, J. A., Chirinos, J. A., De Buyzere, M. L., Gillebert, T. C., Rietzschel, E., Segers, P., Van daele, C. M., Walsh, H. A., Izzo, R., De Luca, N., Trimarco, B., De Simone, G., Goel, K., Misra, A., Chen, P. C., Lin, H. J., T. C., Su, Richards, A. M., Troughton, R., Skov Jensen, J., Paterna, S., Hobbs, F. D. R., Davies, M. K., Davis, R. C., Roalfe, A., Calvert, M., Freemantle, N., Gill, P. S., Lip, G. Y. H., Kuznetsova, T., Staessen, J. A., Dargie, H. J., Ford, I., Mcdonagh, T. A., Mcmurray, J. J. V., Grossman, E., Galasko, G., Lahiri, A., Senior, R., Brown, A., Carrington, M., Krum, H., Mcgrady, M., Stewart, S., Zeitz, C., Blauwet, L., Sliwa, K., Dalen, H., Moelmen Hansen, H. E., Stoylen, A., Thorstensen, A., Daimon, M., Watanabe, H., Yoshikawa, J., Fukuda, S., Kim, H. K., Leung, N. K. W., Linhart, A., Chahal, N., Chambers, J. C., Kooner, J., Davies, J., Loke, I., Ng, L., Squire, I. B., Aune, E., Otterstad, J. E., Leung, D. Y., A. C. T., Ng, Ojji, D., Arnold, L., Coffey, S., D'Arcy, J., Hammond, C., Mabbett, C., Lima, C., Loudon, M., Pinheiro, N., Prendergast, B., Reynolds, R., Badano, L. P., Muraru, D., Peluso, D., DAL BIANCO, Laura, Petrovic, D. J., Petrovic, J., Schvartzman, P., Fuchs, F. D., Katova, T., Simova, I., Kaku, K., Takeuchi, M., Boyd, A., Chia, E. M., Thomas, L., Schirmer, H., Angelo, L. C., Pereira, A. C., Krieger, J. E., Mill, J. G., Rodrigues, S. L., Muiesan, Maria Lorenza, Paini, Anna, AGABITI ROSEI, Enrico, and Salvetti, Massimo
- Subjects
Nuclear Medicine and Imaging ,echocardiography ,ethnic appropriate ,reference ranges ,Cardiology and Cardiovascular Medicine ,Radiology, Nuclear Medicine and Imaging ,Radiology - Published
- 2015
47. Productivity is not enough: A comparison of interactive and nominal groups in idea generation and selection
- Author
-
Rietzschel, E., Nijstad, B.A., Stroebe, W., Social Psychology, Heymans Institute for Psychological Research, Research programme OB, and Arbeids- en Organisatie Psychologie (Psychologie, FMG)
- Abstract
The conclusion that nominal brainstorming groups outperform interactive brainstorming groups has been exclusively based on studies of idea generation. This study tested whether the productivity advantage of nominal groups would also result in better idea selection. Nominal and interactive groups performed a task that involved idea generation and selection. Idea generation and selection were strictly separated for half the groups, but were combined for the other half. Nominal groups generated more ideas than interactive groups, and the ideas generated by nominal groups were more original and less feasible than the ideas generated by interactive groups. However, there were no differences among conditions in quality of the selected ideas. Further, idea selection was not significantly better than chance. This suggests that high productivity in brainstorming is not sufficient to lead to better solutions.
- Published
- 2006
48. Early vascular ageing in translation: from laboratory investigations to clinical applications in cardiovascular prevention
- Author
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Nilsson, P, Boutouyrie, P, Cunhac, P, Kotsis, V, Narkiewicz, K, Parati, G, Rietzschel, E, Scuteri, A, Laurent, S, Nilsson, PM, Laurent, S., PARATI, GIANFRANCO, Nilsson, P, Boutouyrie, P, Cunhac, P, Kotsis, V, Narkiewicz, K, Parati, G, Rietzschel, E, Scuteri, A, Laurent, S, Nilsson, PM, Laurent, S., and PARATI, GIANFRANCO
- Abstract
The ageing of the vascular tree is a fundamental reflection of biological ageing in general and a determinant of organ function. In the arterial wall this is characterized by a reduction in the elastin content, as well as by an increased content of collagen and its cross-linkages, leading to increased arterial stiffness and elevated central as well as brachial blood pressure, accompanied by increased SBP variability. In recent years a better understanding of these processes have led to the proposal of a condition named early vascular ageing (EVA) in patients with increased arterial stiffness for their age and sex. This is a condition that could increase cardiovascular risk and is associated with various degrees of cognitive dysfunction, as well as other features of biological ageing. This brief review aims to give an update on EVA and how the concept can be used in clinical practice.
- Published
- 2013
49. Management of familial hypercholesterolemia in children and young adults : consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization
- Author
-
UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Unité d'endocrinologie pédiatrique, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service de pédiatrie générale, Descamps, O.S., Tenoutasse, S, Stephenne, X, Gies, I., Beauloye, Véronique, Lebrethon, M-C, De Beaufort, C, De Waele, K., Scheen, A., Rietzschel, E., Mangano, A., Panier, J.P., Ducobu, J., Langlois, M., Balligand, Jean-Luc, Legat, P., Blaton, V., Muls, E., Van Gaal, L., Sokal, Etienne, Rooman, R., Carpentier, Y., De Backer, G., Heller, F.R., UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Unité d'endocrinologie pédiatrique, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service de pédiatrie générale, Descamps, O.S., Tenoutasse, S, Stephenne, X, Gies, I., Beauloye, Véronique, Lebrethon, M-C, De Beaufort, C, De Waele, K., Scheen, A., Rietzschel, E., Mangano, A., Panier, J.P., Ducobu, J., Langlois, M., Balligand, Jean-Luc, Legat, P., Blaton, V., Muls, E., Van Gaal, L., Sokal, Etienne, Rooman, R., Carpentier, Y., De Backer, G., and Heller, F.R.
- Abstract
Since heterozygous familial hypercholesterolemia (HeFH) is a disease that exposes the individual from birth onwards to severe hypercholesterolemia with the development of early cardiovascular disease, a clear consensus on the management of this disease in young patients is necessary. In Belgium, a panel of paediatricians, specialists in (adult) lipid management, general practitioners and representatives of the FH patient organization agreed on the following common recommendations. 1. Screening for HeFH should be performed only in children older than 2 years when HeFH has been identified or is suspected (based on a genetic test or clinical criteria) in one parent.2. The diagnostic procedure includes, as a first step, the establishment of a clear diagnosis of HeFH in one of the parents. If this precondition is satisfied, a low-density-lipoprotein cholesterol (LDL-C) levelabove 3.5 mmol/L (135 mg/dL) in the suspected child is predictive for differentiating affected from non-affected children. 3. A low saturated fat and low cholesterol diet should be started after 2 years, under the supervision of a dietician or nutritionist.4. The pharmacological treatment, using statins as first line drugs, should usually be started after 10 years if LDL-C levels remain above 5 mmol/L (190 mg/dL), or above 4 mmol/L (160 mg/dL) in the presence of a causative mutation, a family history of early cardiovascular disease or severe risk factors. The objective is to reduce LDL-C by at least 30% between 10 and 14 years and, thereafter, to reach LDL-C levels of less than 3.4 mmol/L (130 mg/dL).CONCLUSION: The aim of this consensus statement is to achieve more consistent management in the identification and treatment of children with HeFH in Belgium.
- Published
- 2011
50. Management of familial hypercholesterolemia in children and young adults: Consensus paper developed by a panel of lipidologists, cardiologists, paediatricians, nutritionists, gastroenterologists, general practitioners and a patient organization
- Author
-
Descamps, O. S., Tenoutasse, S., Stephenne, X., Gies, I., Beauloye, V., Lebrethon, M.-C., De Beaufort, Carine, De Waele, K., Scheen, A., Rietzschel, E., Mangano, A., Panier, J. P., Ducobu, J., Langlois, M., Balligand, J.-L., Legat, P., Blaton, V., Muls, E., Van Gaal, L., Sokal, E., Rooman, R., Carpentier, Y., De Backer, G., Heller, F. R., Descamps, O. S., Tenoutasse, S., Stephenne, X., Gies, I., Beauloye, V., Lebrethon, M.-C., De Beaufort, Carine, De Waele, K., Scheen, A., Rietzschel, E., Mangano, A., Panier, J. P., Ducobu, J., Langlois, M., Balligand, J.-L., Legat, P., Blaton, V., Muls, E., Van Gaal, L., Sokal, E., Rooman, R., Carpentier, Y., De Backer, G., and Heller, F. R.
- Abstract
Since heterozygous familial hypercholesterolemia (HeFH) is a disease that exposes the individual from birth onwards to severe hypercholesterolemia with the development of early cardiovascular disease, a clear consensus on the management of this disease in young patients is necessary. In Belgium, a panel of paediatricians, specialists in (adult) lipid management, general practitioners and representatives of the FH patient organization agreed on the following common recommendations.1.Screening for HeFH should be performed only in children older than 2 years when HeFH has been identified or is suspected (based on a genetic test or clinical criteria) in one parent.2.The diagnostic procedure includes, as a first step, the establishment of a clear diagnosis of HeFH in one of the parents. If this precondition is satisfied, a low-density-lipoprotein cholesterol (LDL-C) level above 3.5mmol/L (135mg/dL) in the suspected child is predictive for differentiating affected from non-affected children.3.A low saturated fat and low cholesterol diet should be started after 2 years, under the supervision of a dietician or nutritionist.4.The pharmacological treatment, using statins as first line drugs, should usually be started after 10 years if LDL-C levels remain above 5mmol/L (190mg/dL), or above 4mmol/L (160mg/dL) in the presence of a causative mutation, a family history of early cardiovascular disease or severe risk factors. The objective is to reduce LDL-C by at least 30% between 10 and 14 years and, thereafter, to reach LDL-C levels of less than 3.4mmol/L (130mg/dL).Conclusion: The aim of this consensus statement is to achieve more consistent management in the identification and treatment of children with HeFH in Belgium. © 2011 Elsevier Ireland Ltd.
- Published
- 2011
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