26 results on '"Riew, K D"'
Search Results
2. Induction of Bone Formation Using a Recombinant Adenoviral Vector Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model
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Riew, K. D., Wright, N. M., Cheng, S.-L., Avioli, L. V., and Lou, J.
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- 1998
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3. Adjacent Segment Disease Following Cervical Spine Surgery
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Cho, S. K., primary and Riew, K. D., additional
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- 2012
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4. Anti-Apoptotic Effects of Caspase Inhibitors on Rat Intervertebral Disc Cells
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Park, J.-B., primary, Park, I.-C., additional, Park, S.-J., additional, Jin, H.-O., additional, Lee, J.-K., additional, and Riew, K. D., additional
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- 2006
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5. In Vitro and In Vivo Induction of Bone Formation Using a Recombinant Adenoviral Vector Carrying the Human BMP-2 Gene.
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Cheng, S.-L., Lou, J., Wright, N. M., Lai, C.-F., Avioli, L. V., and Riew, K. D.
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BONE growth ,BONE morphogenetic proteins ,GROWTH factors ,ADENOVIRUSES ,GENETIC vectors ,STEM cells ,GENE therapy ,TRANSPLANTATION of organs, tissues, etc. - Abstract
It has been well established that bone morphogenetic protein-2 (BMP-2) can induce bone formation both in vivo and in vitro, although high concentrations (up to milligrams) of BMP-2 have been required to achieve this effect in vivo. Further, clinical applications are usually limited to a single dose at the time of implantation. In an attempt to prolong the transforming effect of BMP-2 we used a recombinant adenoviral vector carrying the human BMP-2 gene (Adv-BMP2) to transduce marrow-derived mesenchymal stem cells (MSC) of skeletally mature male New Zealand white rabbits. The pluripotential MSC were incubated with Adv-BMP2 overnight followed by culture in growth medium for 1 week. Assays on tissue cultures demonstrated that these Adv-BMP2 transduced MSC produced BMP-2 protein, differentiated into an osteoprogenitor line, and induced bone formation in vitro. These MSC had increased alkaline phosphatase activity, increased expression of type I collagen, osteopontin, and osteocalcin mRNA, and induced matrix mineralization compared with both non-transduced cells and cells transduced with a control adenoviral construct. To analyze the osteogenic potential in vivo, Adv-BMP2-transduced MSC were autologously implanted into the intertransverse process space between L5 and L6 of the donor rabbits. The production of new bone was demonstrated by radiographic examination 4 weeks later in areas implanted with cells transduced with Adv-BMP2, whereas no bone was evident at sites implanted with cells transduced with the control adenoviral construct. Histological examination further confirmed the presence of new bone formation. These accumulated data indicate that it is possible to successfully transduce mesenchymal stem cells with a recombinant adenoviral vector carrying the gene for BMP-2 such that these cells will produce BMP-2, differentiate into an osteoprogenitor line, and induce bone formation both in vitro and in vivo. Moreover, incubation of the Adv-BMP2-transduced cells for an additional 7 days in culture before transplantation enhances the success rate in bone formation (three out of three) as compared with our previous report (one out of five, Calcif Tissue Int 63:357–360, 1998). [ABSTRACT FROM AUTHOR]
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- 2001
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6. The effect of nerve-root injections on the need for operative treatment of lumbar radicular pain. A prospective, randomized, controlled, double-blind study.
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Riew KD, Yin Y, Gilula L, Bridwell KH, Lenke LG, Lauryssen C, Goette K, Riew, K D, Yin, Y, Gilula, L, Bridwell, K H, Lenke, L G, Lauryssen, C, and Goette, K
- Abstract
Background: The purpose of the present study was to determine the effectiveness of selective nerve-root injections in obviating the need for an operation in patients with lumbar radicular pain who were otherwise considered to be operative candidates. Although selective nerve-root injections are used widely, we are not aware of any prospective, randomized, controlled, double-blind studies demonstrating their efficacy.Methods: Fifty-five patients who were referred to four spine surgeons because of lumbar radicular pain and who had radiographic confirmation of nerve-root compression were prospectively randomized into the study. All of the patients had to have requested operative intervention and had to be considered operative candidates by the treating surgeon. They then were randomized and referred to a radiologist who performed a selective nerve-root injection with either bupivacaine alone or bupivacaine with betamethasone. The treating physicians and the patients were blinded to the medication. The patients were allowed to choose to receive as many as four injections. The treatment was considered to have failed if the patient proceeded to have the operation, which he or she could opt to do at any point in the study.Results: Twenty-nine of the fifty-five patients, all of whom had initially requested operative treatment, decided not to have the operation during the follow-up period (range, thirteen to twenty-eight months) after the nerve-root injections. Of the twenty-seven patients who had received bupivacaine alone, nine elected not to have the operation. Of the twenty-eight patients who had received bupivacaine and betamethasone, twenty decided not to have the operation. The difference in the operative rates between the two groups was highly significant (p < 0.004).Conclusions: Our data demonstrate that selective nerve-root injections of corticosteroids are significantly more effective than those of bupivacaine alone in obviating the need for a decompression for up to thirteen to twenty-eight months following the injections in operative candidates. This finding suggests that patients who have lumbar radicular pain at one or two levels should be considered for treatment with selective nerve-root injections of corticosteroids prior to being considered for operative intervention. [ABSTRACT FROM AUTHOR]- Published
- 2000
7. Analysis of titanium mesh cages in adults with minimum two-year follow-up.
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Eck KR, Bridwell KH, Ungacta FF, Lapp MA, Lenke LG, Riew KD, Eck, K R, Bridwell, K H, Ungacta, F F, Lapp, M A, Lenke, L G, and Riew, K D
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- 2000
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8. Synovial chondromatosis in a facet joint of a cervical vertebra.
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Kyriakos, M, Totty, W G, and Riew, K D
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- 2000
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9. Complications of buttress plate stabilization of cervical corpectomy.
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Riew KD, Sethi NS, Devney J, Goette K, Choi K, Riew, K D, Sethi, N S, Devney, J, Goette, K, and Choi, K
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- 1999
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10. Comparison of computed tomography myelography and magnetic resonance imaging in the evaluation of cervical spondylotic myelopathy and radiculopathy.
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Shafaie, F F, Wippold, F J 2nd, Gado, M, Pilgram, T K, and Riew, K D
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- 1999
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11. Neurologic complications of pediatric femoral nailing.
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Riew, K. Daniel, Sturm, Peter F., Rosenbaum, Donald, Robertson Jr., William W., Yamaguchi, Ken, Riew, K D, Sturm, P F, Rosenbaum, D, Robertson, W W Jr, and Yamaguchi, K
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- 1996
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12. Association of myelopathy scores with cervical sagittal balance and normalized spinal cord volume: analysis of 56 preoperative cases from the AOSpine North America Myelopathy study
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Smith, J. S., Virginie Lafage, Ryan, D. J., Shaffrey, C. I., Schwab, F. J., Patel, A. A., Brodke, D. S., Arnold, P. M., Riew, K. D., Traynelis, V. C., Radcliff, K., Vaccaro, A. R., Fehlings, M. G., and Ames, C. P.
13. Undetected vertebral artery groove and foramen violations during C1 lateral mass and C2 pedicle screw placement
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Yeom, J. S., Buchowski, J. M., Park, K. W., Chang, B. S., Choon-Ki Lee, and Riew, K. D.
14. Addressing a national crisis: the spine hospital and department's response to the COVID-19 pandemic in New York City.
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Lombardi, JM, Bottiglieri, T, Desai, N, Riew, KD, Boddapati, V, Weller, M, Bourgois, C, McChrystal, S, Lehman, RA, Lombardi, J M, Riew, K D, and Lehman, R A
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COVID-19 pandemic , *SPINE , *COVID-19 , *HOSPITAL personnel , *HOSPITALS - Abstract
In a very brief period, the COVID-19 pandemic has swept across the planet leaving governments, societies, and healthcare systems unprepared and under-resourced. New York City now represents the global viral epicenter with roughly one-third of all mortalities in the United States. To date, our hospital has treated thousands of COVID-19 positive patients and sits at the forefront of the United States response to this pandemic. The goal of this paper is to share the lessons learned by our spine division during a crisis when hospital resources and personnel are stretched thin. Such experiences include management of elective and emergent cases, outpatient clinics, physician redeployment, and general health and wellness. As peak infections spread across the United States, we hope this article will serve as a resource for other spine departments on how to manage patient care and healthcare worker deployment during the COVID-19 crisis. [ABSTRACT FROM AUTHOR]
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- 2020
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15. Results of cervical arthroplasty compared with anterior discectomy and fusion: four-year clinical outcomes in a prospective, randomized controlled trial.
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Sasso RC, Anderson PA, Riew KD, and Heller JG
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- Cervical Vertebrae physiopathology, Disability Evaluation, Diskectomy adverse effects, Humans, Intervertebral Disc Degeneration physiopathology, Pain, Postoperative Complications, Prospective Studies, Prostheses and Implants, Spinal Fusion adverse effects, Total Disc Replacement adverse effects, Total Disc Replacement instrumentation, Treatment Outcome, Cervical Vertebrae surgery, Diskectomy methods, Intervertebral Disc Degeneration surgery, Spinal Fusion methods, Total Disc Replacement methods
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- 2011
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16. Value of diagnostic lumbar selective nerve root block: a prospective controlled study.
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Yeom JS, Lee JW, Park KW, Chang BS, Lee CK, Buchowski JM, and Riew KD
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- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity, Low Back Pain diagnosis, Low Back Pain therapy, Nerve Block methods
- Abstract
Background and Purpose: Although diagnostic lumbar selective nerve root blocks are often used to confirm the pain-generating nerve root level, the reported accuracy of these blocks has been variable and their usefulness is controversial. The purpose of this study was to evaluate the accuracy of diagnostic lumbar selective nerve root blocks to analyze potential causes of false results in a prospective, controlled, single-blinded manner., Materials and Methods: A total of 105 block anesthetics were performed under fluoroscopic guidance in 47 consecutive patients with pure radiculopathy from a single confirmed level: 47 blocks were performed at the symptomatic level, and 58 were performed at the adjacent asymptomatic "control" level. Contrast and local anesthetics were injected, and spot radiographs were taken in all cases. We calculated the diagnostic value of the block anesthetics using concordance with the injected level. We analyzed the potential causes of false results using spot radiographs., Results: On the basis of a definition of a positive block as 70% pain relief, determined by receiver-operator characteristic (ROC) analysis, diagnostic lumbar selective nerve root block anesthetics had a sensitivity of 57%, a specificity of 86%, an accuracy of 73%, a positive predictive value of 77%, and a negative predictive value of 71%. False-negatives were due to the following causes identifiable on spot radiographs: insufficient infiltration, insufficient passage of the injectate, and intraepineural injections. On the other hand, false-positives resulted from overflow of the injectate from the injected asymptomatic level into either the epidural space or symptomatic level., Conclusion: The accuracy of diagnostic lumbar selective nerve root blocks is only moderate. To improve the accuracy, great care should be taken to avoid inadequate blocks and overflow, and to precisely interpret spot radiographs.
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- 2008
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17. Complications and results of long adult deformity fusions down to l4, l5, and the sacrum.
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Eck KR, Bridwell KH, Ungacta FF, Riew KD, Lapp MA, Lenke LG, Baldus C, and Blanke K
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- Adult, Equipment Failure, Humans, Middle Aged, Orthopedic Fixation Devices adverse effects, Palliative Care, Pseudarthrosis etiology, Radiography, Recovery of Function, Reoperation, Scoliosis physiopathology, Spinal Diseases diagnostic imaging, Spinal Diseases etiology, Surgical Wound Infection, Treatment Outcome, Lumbar Vertebrae surgery, Sacrum surgery, Scoliosis surgery, Spinal Fusion adverse effects
- Abstract
Study Design: This is a consecutive study of patients having undergone surgical treatment of adult lumbar scoliosis. Follow-up ranged from 2 to 13 years (average 5 years)., Objectives: To assess the complications and outcomes of patients with long fusions to L4 (n=23), L5 (n=21), or the sacrum (n=15) and determine if a "deeply seated" L5 segment is protective., Summary of Background Data: Few studies assess outcomes and complications in adults fused from the thoracic spine to L4, L5, or the sacrum with minimum 2-year follow-up., Methods: Fifty-eight patients (59 cases; average age 43 years; range 21 to 60) with minimum 2-year follow-up were analyzed for subsequent spinal degeneration and complications. Outcomes were assessed from questionnaires administered at latest follow-up., Results: Sixteen percent of cases (7 of 44) fused short of the sacrum displayed subsequent postoperative distal spinal degeneration, although only three patients were symptomatic. Compared with the group with no subsequent degeneration, this group had a lower improvement in function and pain relief. Other complications for patients fused short of the sacrum included two cases with crosslink breakage, one with neurologic deficit, three with pseudarthroses, one with hook pullout, and one with L5 screw pullout. For cases fused to the sacrum, two cases with deep wound infections and one with loose iliac screw requiring removal were observed. Because two of four cases fused to L5 with subsequent degeneration at L5-S1 were observed to have "deeply seated" L5 segments and two of the four did not, the authors could conclude only that "deep seating" of L5 is not absolute protection., Conclusions: Fusions short of the sacrum did not have predictable long-term results. Those fused short of the sacrum who developed distal spinal degeneration had worse outcomes. Patients fused to the sacrum did not have a higher complication rate. A "deeply seated" L5 segment does not necessarily protect the L5-S1 disc.
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- 2001
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18. Diagnosing basilar invagination in the rheumatoid patient. The reliability of radiographic criteria.
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Riew KD, Hilibrand AS, Palumbo MA, Sethi N, and Bohlman HH
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- Adult, Aged, Aged, 80 and over, Arthritis, Rheumatoid diagnostic imaging, Female, Humans, Joint Deformities, Acquired etiology, Male, Middle Aged, Observer Variation, Odontoid Process diagnostic imaging, Platybasia diagnostic imaging, Radiography, Reproducibility of Results, Sensitivity and Specificity, Arthritis, Rheumatoid complications, Atlanto-Axial Joint, Joint Deformities, Acquired diagnostic imaging, Occipital Bone diagnostic imaging, Occipital Bone pathology
- Abstract
Background: Basilar invagination can be difficult to diagnose with plain radiography in patients with rheumatoid arthritis. Although numerous radiographic criteria have been described, few studies have addressed the reliability of these parameters in the rheumatoid population. The purpose of the present study was to validate and compare the most widely accepted plain radiographic criteria for basilar invagination in this patient population., Methods: Cervical radiographs of 131 rheumatoid patients were examined. Of these patients, sixty-seven (twenty-nine with basilar invagination and thirty-eight without it) were also evaluated with tomograms, magnetic resonance imaging, and/or sagittally reconstructed computed tomography scans to detect the presence of basilar invagination. Three observers who were blinded with regard to the diagnosis independently scored each radiograph as positive, negative, or indeterminate according to the established criteria for invagination proposed by Clark et al., McRae and Barnum, Chamberlain, McGregor, Redlund-Johnell and Pettersson, Ranawat et al., Fischgold and Metzger, and Wackenheim. Interobserver and intraobserver variability, sensitivity, specificity, total percentage of correct results, and negative and positive predictive values were determined for each criterion as well as for various combinations of the criteria., Results: No single test had a sensitivity and a negative predictive value of greater than 90% as well as a reasonable specificity and a reasonable positive predictive value. The combination of the Clark station, the Redlund-Johnell criterion, and the Ranawat criterion, scored as positive for basilar invagination if any of the three were positive, proved to be better than any single criterion; the sensitivity of the combined criteria was 94%, and the negative predictive value was 91%., Conclusions: A screening test for basilar invagination should have a high sensitivity and a high negative predictive value, so that the disease will not be missed, and yet be specific, so that the disease will not be overdiagnosed. Our data suggest that none of the widely utilized plain radiographic criteria meet these goals. We recommend that measurements be made according to the methods described by Clark et al., Redlund-Johnell et al., and Ranawat et al. and, if any of these suggests basilar invagination, tomography or magnetic resonance imaging should be performed. Since approximately 6% of the cases of basilar invagination in rheumatoid patients would still be missed with this approach, tomography or magnetic resonance imaging should be performed on a rheumatoid patient whenever plain radiographs leave any doubt about the diagnosis of basilar invagination.
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- 2001
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19. Radiographic assessment of anterior titanium mesh cages.
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Eck KR, Lenke LG, Bridwell KH, Gilula LA, Lashgari CJ, and Riew KD
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- Adolescent, Adult, Aged, Aged, 80 and over, Child, Follow-Up Studies, Humans, Internal Fixators, Middle Aged, Postoperative Complications pathology, Prostheses and Implants, Radiography, Spinal Fusion, Spine diagnostic imaging, Spine pathology, Titanium adverse effects, Treatment Failure, Postoperative Complications diagnostic imaging, Postoperative Complications etiology, Spine surgery, Titanium therapeutic use
- Abstract
Carbon fiber and titanium cage implantation for anterior column support during spinal fusions is an alternative to the use of more traditional structural allografts and autografts. The authors report instrumentation and cage failure for patients who underwent spinal fusion with structural titanium mesh cages implanted into the anterior column a minimum of 2 years after surgery. They wanted to determine whether plain radiographic techniques can be used to critically assess disk space and corpectomy fusions after implantation of these radioopaque cages. Fifty patients having undergone spinal fusions using structural titanium mesh cages in the anterior column had 99 anterior levels fused with at least 1 (maximum of 2) titanium mesh cage, resulting in a total of 131 cages used. The cages were examined for evidence of settling, migration, or failure. The anterior and posterior instrumentation was assessed for evidence of failure, and the spine was examined for evidence of successful fusion. Radiographic cage settling (>2 mm) into the vertebral body end plates was observed, but cage migration or failure were not. An average lordotic correction of 10 degrees was observed, with loss of correction into kyphosis from immediately after operation to final follow-up averaging 2 degrees. As an average of all reviewers, using a strict radiographic fusion assessment, definite or probable anterior fusion was graded at 81% of the levels, probably not or no at 5% of the levels, and could not be assessed at 14% of the levels. Definite or probable posterior fusion as an average of all reviewers was graded at 44% of the posterior fusion levels, questionable at 4%, no at 5%, and could not be assessed at 47%. The use of anterior-only, posterior-only, or anterior and posterior instrumentation with structural titanium mesh cages in the anterior spine along with proper autogenous bone grafting techniques provided anterior column support with a low rate of radiographic complications. Acceptable anterior spinal fusion rates, as assessed by a consensus agreement of reviewers, were observed primarily by evaluation of the fusion mass around the cages (extracage fusion), because intracage fusion was difficult to assess.
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- 2000
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20. Complications in the surgical treatment of pediatric high-grade, isthmic dysplastic spondylolisthesis. A comparison of three surgical approaches.
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Molinari RW, Bridwell KH, Lenke LG, Ungacta FF, and Riew KD
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- Adolescent, Adult, Child, Decompression, Surgical, Female, Humans, Incidence, Male, Nervous System Diseases etiology, Orthopedic Fixation Devices, Pseudarthrosis diagnostic imaging, Pseudarthrosis epidemiology, Pseudarthrosis etiology, Radiography, Reoperation, Spinal Fusion, Spine diagnostic imaging, Treatment Outcome, Postoperative Complications, Spondylolisthesis surgery
- Abstract
Study Design: An analysis of consecutive pediatric patients treated surgically for high-grade spondylolisthesis by one of three surgical procedures with emphasis on complications and functional outcomes., Objective: Complications, radiographic results and patient-assessed function, pain, and satisfaction were assessed among three surgical procedures., Summary of Background Data: The existing literature is in disagreement about whether it is better to fuse without instrumented reduction or to use instrumentation and reduce high-grade dysplastic spondylolisthesis., Methods: Thirty-two patients had 37 surgical procedures for Meyerding Grade 3 or 4 isthmic dysplastic spondylolisthesis. Eleven patients were treated with an in situ L4-sacrum posterior fusion without decompression (Group 1), 7 had posterior decompression with posterior instrumentation and posterior fusion (Group 2), and 19 patients had reduction and a circumferential fusion procedure (Group 3). All patients had new radiographs taken at time of follow-up (average, 3.1 years; range, 2 years-10 years, 1 month) and completed a functional outcome questionnaire., Results: The incidence of pseudarthrosis was 45% (5 of 11) in Group 1, 29% (2 of 7) in Group 2, and 0% (0 of 19) in Group 3. All seven who had pseudarthrosis had small L5 transverse process surface area (< 2 cm2; P = 0.004). Only one patient had a neurologic deficit (unilateral extensor hallucis longus weakness) at time of follow-up. There were no significant differences among the groups in function, pain, and satisfaction in patients in whom solid fusion was obtained, but the scores were highest in Group 3., Conclusions: In situ fusion surgery in patients with high-grade spondylolisthesis with small L5 transverse processes (surface area, < 2 cm2) results in a high rate of pseudarthrosis. Circumferential procedures result in the highest rate of fusion and are effective in achieving fusion in those patients with established pseudarthrosis. The use of long (> 60 mm) iliac screws bilaterally (n = 21) in addition to bicortical sacral screws (four-point sacral-pelvis fixation) along with anterior column fusion reduces the risk of instrumentation failure in a decompression and reduction procedure. Outcomes of function, pain, and satisfaction are excellent in those in whom fusion is achieved. The risks in circumferential fusion-reduction procedures are acceptable.
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- 1999
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21. Anterior cervical corpectomy in patients previously managed with a laminectomy: short-term complications.
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Riew KD, Hilibrand AS, Palumbo MA, and Bohlman HH
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- Adult, Aged, Bone Plates, Bone Transplantation, Bone Wires, Cervical Vertebrae diagnostic imaging, Female, Follow-Up Studies, Humans, Immobilization, Male, Middle Aged, Postoperative Complications diagnostic imaging, Reoperation, Retrospective Studies, Spinal Cord Compression diagnostic imaging, Tomography, X-Ray Computed, Treatment Outcome, Cervical Vertebrae surgery, Laminectomy, Postoperative Complications surgery, Spinal Cord Compression surgery, Spinal Fusion
- Abstract
Background: The purpose of this study was to evaluate the complications of anterior cervical corpectomy and arthrodesis in patients who had had a previous cervical laminectomy. The results of previous studies have suggested that these patients can be managed with anterior decompression and an arthrodesis with either plate fixation or immobilization in a halo vest. However, no studies that we are aware of have specifically focused on the complications of these types of procedures., Methods: The records and radiographs of eighteen patients who had been managed with a one to four-level corpectomy with strut-grafting were retrospectively reviewed. The reviews were independently performed by the three of us who were not involved in the original operation. The interval between the laminectomy and the corpectomy ranged from one month to twenty-two years (mean, eight years)., Results: Eleven of the eighteen patients sustained a total of sixteen complications during the follow-up period, which averaged 2.7 years (range, seven months to six years and four months), and nine of the eleven had graft-related complications. Five grafts extruded or collapsed, or both. There were four reoperations. Immobilization in a halo vest did not prevent extrusions, as three of the four extrusions occurred while the patient wore a halo vest. Four patients had a pseudarthrosis. In three patients, the kyphosis increased by 10 degrees or more from the immediate preoperative period to the most recent follow-up evaluation. Two patients had respiratory distress that necessitated reintubation, one patient had a small dural tear, and one had transient dysphagia., Conclusions: Our data suggest that anterior cervical corpectomy without instrumentation in a patient who has had a previous laminectomy is associated with a great risk of graft-related complications despite the use of a halo vest. This previously unreported finding is relevant in that it contradicts the recommendation previously made by Zdeblick and the senior one of us, who advocated postoperative immobilization in a halo vest for these patients. Anterior cervical corpectomy should be performed with caution and knowledge of the potential complications in a patient who has had a previous laminectomy.
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- 1999
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22. Dural tears secondary to operations on the lumbar spine. Management and results after a two-year-minimum follow-up of eighty-eight patients.
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Wang JC, Bohlman HH, and Riew KD
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- Bed Rest, Female, Follow-Up Studies, Humans, Intraoperative Complications therapy, Male, Middle Aged, Postoperative Care, Prevalence, Reoperation, Suction, Time Factors, Dura Mater injuries, Intraoperative Complications epidemiology, Lumbar Vertebrae surgery
- Abstract
We reviewed the results of acute management of patients who had sustained a dural tear during an operation on the lumbar spine, and we attempted to determine the long-term sequelae of this complication. In the five years from July 1989 to July 1994, 641 consecutive patients had a decompression of the lumbar spine, performed by the senior one of us; of these patients, eighty-eight (14 percent) sustained a dural tear, which was repaired during the operation. The duration of follow-up ranged from two to eight years (average, 4.3 years). Postoperative management consisted of closed suction wound drainage for an average of 2.1 days and bed rest for an average of 2.9 days. Of the eighty-eight procedures that resulted in a dural tear, forty-five were revisions; these revisions were performed after an average of 2.2 previous operations on the lumbar spine, all of which resulted in a scar adherent to the dura. Only eight patients had headaches related to the spinal procedure and photophobia in the postoperative period; these symptoms resolved in all but two patients, both of whom had had a revision operation. Each of the two patients had symptoms of a persistent leak of spinal fluid and needed a reoperation for repair. Overall, seventy-six patients had a good or excellent result and twelve had a poor or satisfactory result with some residual back pain. One patient had arachnoiditis, and another had symptoms of viral meningitis one month postoperatively. A dural tear that occurs during an operation on the lumbar spine can be treated successfully with primary repair followed by bed rest. Such a tear does not appear to have any long-term deleterious effects or to increase the risk of postoperative infection, neural damage, or arachnoiditis. Closed suction wound drainage does not seem to aggravate the leak and can be used safely in the presence of a dural repair.
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- 1998
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23. Failed anterior cervical discectomy and arthrodesis. Analysis and treatment of thirty-five patients.
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Zdeblick TA, Hughes SS, Riew KD, and Bohlman HH
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- Adult, Aged, Cervical Vertebrae diagnostic imaging, Female, Humans, Intervertebral Disc Displacement surgery, Kyphosis surgery, Male, Middle Aged, Radiography, Spinal Diseases diagnostic imaging, Treatment Failure, Arthrodesis, Cervical Vertebrae surgery, Diskectomy, Spinal Diseases surgery
- Abstract
Thirty-five patients were managed operatively after failure of an anterior cervical discectomy and arthrodesis. Failure was classified as the absence of fusion without deformity but with neck pain or radiculopathy, or both; the absence of fusion after anterior or posterior dislodgment of the graft; or kyphosis due to collapse of the graft or to an unrecognized posterior soft-tissue injury. Twenty-three patients had failure of the arthrodesis without deformity (with neck pain only, neck and arm pain, radiculopathy, or myelopathy). Four patients had dislodgment of the graft; in two of them the graft migrated anteriorly after a multilevel Robinson arthrodesis, and in two it migrated posteriorly after a Cloward arthrodesis. Eight patients had a failure because of a kyphotic deformity. Five of them had had a Cloward arthrodesis; one, a discectomy; and two, a Robinson arthrodesis. Six had received allograft bone. Operative treatment of the pseudarthrosis consisted of repeat resection of the disc space in the area of the failed arthrodesis followed by repeat anterior Robinson arthrodesis with decompression of the nerve root if the patient had radiculopathy. It consisted of anterior corpectomy or vertebral-body resection and strut-grafting with reduction of the deformity if the patient had migration of the graft and kyphosis. The reoperations were performed four months to fourteen years (average, thirty-two months) after the initial operation. The duration of follow-up after the second operation averaged forty-four months (range, twenty-four to 216 months). The result was excellent for twenty-nine patients, good for one, fair for four, and poor for one. We concluded that, in patients who have persistent symptoms after an anterior cervical arthrodesis, an excellent result can be achieved with repeat anterior decompression and autogenous bone-grafting.
- Published
- 1997
24. Biceps activity during shoulder motion: an electromyographic analysis.
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Yamaguchi K, Riew KD, Galatz LM, Syme JA, and Neviaser RJ
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- Adult, Arm physiology, Electromyography, Humans, Middle Aged, Muscle Contraction physiology, Prospective Studies, Rotator Cuff Injuries, Rupture, Movement physiology, Muscle, Skeletal physiology, Shoulder physiology
- Abstract
Electromyographic responses in 44 shoulders from 30 subjects were examined. Fourteen shoulders from 13 patients had documented rotator cuff tears. The remaining volunteers had normal cuff integrity by history and examination. Electromyographic responses were recorded from the long head of the biceps, brachioradialis (elbow control), and from the supraspinatus (shoulder control). Elbow related biceps activity was minimized by using a brace locked in neutral forearm rotation and 100 degrees flexion. Analysis of normal and rotator cuff deficient data was performed in a masked fashion and electromyographic activity normalized as a percent of maximal muscle contraction during 10 shoulder motions based on the scapular plane. Normal shoulders in all ranges of active motion exhibited significant supraspinatus activity (20%-50% maximum muscle contraction). The response followed patterns expected for a shoulder stabilizer. In contrast, with every normal shoulder, biceps and brachioradialis activity remained insignificant (1.7%-3.6% maximum muscle contraction) and did not follow a patterned response. In patients with rotator cuff tears, biceps activity remained low (1.6%-4.4% maximum muscle contraction). As opposed to previous studies using electromyography about the shoulder, this trial examined shoulder specific biceps activity by relaxing the elbow. No significant biceps activity was observed in any shoulder, including patients with rotator cuff tears. Given these findings, any function of the long head of the biceps in shoulder motion does not involve active contractions.
- Published
- 1997
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25. Orientation of the lumbar facet joints: association with degenerative disc disease.
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Boden SD, Riew KD, Yamaguchi K, Branch TP, Schellinger D, and Wiesel SW
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- Adult, Humans, Intervertebral Disc pathology, Joints anatomy & histology, Joints pathology, Lumbar Vertebrae anatomy & histology, Magnetic Resonance Imaging, Osteoarthritis pathology, Reproducibility of Results, Intervertebral Disc Displacement pathology, Lumbar Vertebrae pathology, Spondylolisthesis pathology
- Abstract
The orientation of the lumbar facet joints was studied with magnetic resonance imaging in 140 subjects to determine if there is an association between facet tropism and intervertebral disc disease or between the orientation of the facet joints and degenerative spondylolisthesis. The 140 subjects were divided into four groups: sixty-seven asymptomatic volunteers, forty-six of whom did not have a herniated disc on magnetic resonance scans (Group I) and twenty-one who did (Group II); forty-six symptomatic patients who had a herniated disc confirmed operatively (Group III); and twenty-seven patients who had degenerative spondylolisthesis at the interspace between the fourth and fifth lumbar vertebrae (Group IV). Axial scans were made at each lumbar level and digitized, and the facet joint angle was measured by two independent observers with use of image analysis software in a personal computer. The technique of measurement of the facet angles on magnetic resonance scans was validated with a subset of subjects who also had computed tomography scans made. Similar values were obtained with the two methods (r = 0.92; p = 0.00001). For the forty-six asymptomatic volunteers who did not have a herniated disc on the magnetic resonance scans (Group I), the median facet tropism was 5 to 6 degrees and was more than 10 degrees in 24 per cent (eleven) of the subjects. There was no association between increased facet tropism and disc degeneration. At the level of the fourth and fifth lumbar vertebrae, the median facet tropism was 10.3 degrees in the symptomatic patients who had a herniated disc at the same level and 5.4 degrees in the asymptomatic volunteers (Group I) (p = 0.05). The mean orientation of the lumbar facet angles relative to the coronal plane was more sagittal at all levels in the patients who had degenerative spondylolisthesis. The greatest difference was at the level of the fourth and fifth lumbar vertebrae (p = 0.000001). The mean facet angle was 41 degrees (95 per cent confidence interval, 37.6 to 44.6 degrees) in the asymptomatic volunteers and 60 degrees (95 per cent confidence interval, 52.7 to 67.1 degrees) in the patients who had degenerative spondylolisthesis. Furthermore, both the left and the right facet joints were more sagittally oriented in the patients who had degenerative spondylolisthesis. An individual in who both facet-joint angles at the level of the fourth and fifth lumbar vertebrae were more than 45 degrees relative to the coronal plane was twenty-five times more likely to have degenerative spondylolisthesis (95 per cent confidence interval, seven to ninety-eight times). The increase in facet angles at levels other than that of the spondylolisthesis suggests that increased facet angles represent variations in anatomy rather than a secondary result of spondylolisthesis.
- Published
- 1996
- Full Text
- View/download PDF
26. Reversal of a calcium-mediated vasoconstrictor component in patients with congestive heart failure.
- Author
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Cody RJ, Riew KD, and Kubo SH
- Subjects
- Calcium Channels drug effects, Dose-Response Relationship, Drug, Female, Hemodynamics drug effects, Humans, Infusions, Intra-Arterial, Male, Middle Aged, Reference Values, Regional Blood Flow drug effects, Vascular Resistance drug effects, Forearm blood supply, Heart Failure physiopathology, Nicardipine administration & dosage, Vasoconstriction drug effects
- Abstract
The influx of calcium into vascular smooth muscle cells is a major determinant of vasoconstriction, yet this concept has not been explored in congestive heart failure (CHF). We therefore used an "isolated" forearm model to assess the direct effects of the inhibition of calcium influx into vascular smooth muscle in 11 patients who had CHF, with use of the soluble dihydropyridine, nicardipine. Nicardipine produced a dose-dependent increase of forearm blood flow and a reduction of resistance, without producing a systemic hemodynamic effect. Patients with the lowest baseline forearm blood flow levels had the greatest percentage increases in forearm blood flow (r = -0.729, p less than 0.01), and a favorable metabolic effect was documented by a reduction in oxygen extraction across the forearm. This study demonstrated the importance of vascular smooth muscle intracellular calcium as a determinant of vasoconstriction in patients who have CHF.
- Published
- 1989
- Full Text
- View/download PDF
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