25 results on '"Rigotti, Erika"'
Search Results
2. Breastfeeding rates fell in an Italian baby friendly hospital during the 2020 COVID ‐19 pandemic year and difficulties increased
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Cinquetti, Mauro, primary, Marchiotto, Carolina, additional, Fingerle, Michele, additional, Salani, Marco, additional, Adami, Anna, additional, Dainese, Daniela, additional, Magaraggia, Silvia, additional, Rigotti, Erika, additional, and Piacentini, Giorgio, additional
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- 2023
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3. Surgical Antimicrobial Prophylaxis in Abdominal Surgery for Neonates and Paediatrics: A RAND/UCLA Appropriateness Method Consensus Study
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Bianchini, Sonia, Rigotti, Erika, Monaco, Sara, Nicoletti, Laura, Auriti, Cinzia, Castagnola, Elio, Conti, Giorgio, Galli, Luisa, Giuffrè, Mario, La Grutta, Stefania, Lancella, Laura, Lo Vecchio, Andrea, Maglietta, Giuseppe, Petrosillo, Nicola, Pietrasanta, Carlo, Principi, Nicola, Tesoro, Simonetta, Venturini, Elisabetta, Piacentini, Giorgio, Lima, Mario, Staiano, Annamaria, Esposito, Susanna, The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, null, Bianchini S., Rigotti E., Monaco S., Nicoletti L., Auriti C., Castagnola E., Conti G., Galli L., Giuffre M., La Grutta S., Lancella L., Lo Vecchio A., Maglietta G., Petrosillo N., Pietrasanta C., Principi N., Tesoro S., Venturini E., Piacentini G., Lima M., Staiano A., Esposito S., Bianchini, Sonia, Rigotti, Erika, Monaco, Sara, Nicoletti, Laura, Auriti, Cinzia, Castagnola, Elio, Conti, Giorgio, Galli, Luisa, Giuffrè, Mario, La Grutta, Stefania, Lancella, Laura, Lo Vecchio, Andrea, Maglietta, Giuseppe, Petrosillo, Nicola, Pietrasanta, Carlo, Principi, Nicola, Tesoro, Simonetta, Venturini, Elisabetta, Piacentini, Giorgio, Lima, Mario, Staiano, Annamaria, Esposito, Susanna, and The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Null
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Microbiology (medical) ,Infectious Diseases ,pancreas surgery ,Settore MED/41 - ANESTESIOLOGIA ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,abdominal surgery ,gastrointestinal endoscopy ,Biochemistry ,Microbiology ,appendectomy ,liver surgery - Abstract
Surgical site infections (SSIs), i.e., surgery-related infections that occur within 30 days after surgery without an implant and within one year if an implant is placed, complicate surgical procedures in up to 10% of cases, but an underestimation of the data is possible since about 50% of SSIs occur after the hospital discharge. Gastrointestinal surgical procedures are among the surgical procedures with the highest risk of SSIs, especially when colon surgery is considered. Data that were collected from children seem to indicate that the risk of SSIs can be higher than in adults. This consensus document describes the use of preoperative antibiotic prophylaxis in neonates and children that are undergoing abdominal surgery and has the purpose of providing guidance to healthcare professionals who take care of children to avoid unnecessary and dangerous use of antibiotics in these patients. The following surgical procedures were analyzed: (1) gastrointestinal endoscopy; (2) abdominal surgery with a laparoscopic or laparotomy approach; (3) small bowel surgery; (4) appendectomy; (5) abdominal wall defect correction interventions; (6) ileo-colic perforation; (7) colorectal procedures; (8) biliary tract procedures; and (9) surgery on the liver or pancreas. Thanks to the multidisciplinary contribution of experts belonging to the most important Italian scientific societies that take care of neonates and children, this document presents an invaluable reference tool for perioperative antibiotic prophylaxis in the paediatric and neonatal populations.
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- 2022
4. Surgical Antimicrobial Prophylaxis in Neonates and Children with Special High-Risk Conditions: A RAND/UCLA Appropriateness Method Consensus Study
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Bianchini, Sonia, Rigotti, Erika, Nicoletti, Laura, Monaco, Sara, Auriti, Cinzia, Castagnola, Elio, Castelli Gattinara, Guido, De Luca, Maia, Galli, Luisa, Garazzino, Silvia, La Grutta, Stefania, Lancella, Laura, Lo Vecchio, Andrea, Maglietta, Giuseppe, Montagnani, Carlotta, Petrosillo, Nicola, Pietrasanta, Carlo, Principi, Nicola, Simonini, Alessandra, Tesoro, Simonetta, Venturini, Elisabetta, Piacentini, Giorgio, Lima, Mario, Staiano, Annamaria, Esposito, Susanna, On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Null, Bianchini, Sonia, Rigotti, Erika, Nicoletti, Laura, Monaco, Sara, Auriti, Cinzia, Castagnola, Elio, Castelli Gattinara, Guido, De Luca, Maia, Galli, Luisa, Garazzino, Silvia, La Grutta, Stefania, Lancella, Laura, Lo Vecchio, Andrea, Maglietta, Giuseppe, Montagnani, Carlotta, Petrosillo, Nicola, Pietrasanta, Carlo, Principi, Nicola, Simonini, Alessandra, Tesoro, Simonetta, Venturini, Elisabetta, Piacentini, Giorgio, Lima, Mario, Staiano, Annamaria, Esposito, Susanna, and On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Null
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Microbiology (medical) ,immunosuppression ,multidrug resistant bacteria ,antibiotic allergy ,comorbidity ,MRSA ,MSSA ,splenectomy ,surgical antibiotic prophylaxis ,Keywords: antibiotic allergy ,Biochemistry ,Microbiology ,Infectious Diseases ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,surgical antibiotic prophylaxis 1. Introduction - Abstract
Surgical site infections (SSIs), which are a potential complications in surgical procedures, are associated with prolonged hospital stays and increased postoperative mortality rates, and they also have a significant economic impact on health systems. Data in literature regarding risk factors for SSIs in pediatric age are scarce, with consequent difficulties in the management of SSI prophylaxis and with antibiotic prescribing attitudes in the various surgical procedures that often tend to follow individual opinions. The lack of pediatric studies is even more evident when we consider surgeries performed in subjects with underlying conditions that may pose an increased risk of complications. In order to respond to this shortcoming, we developed a consensus document to define optimal surgical antimicrobial prophylaxis (SAP) in neonates and children with specific high-risk conditions. These included the following: (1) colonization by methicillin-resistant Staphylococcus aureus (MRSA) and by multidrug resistant (MDR) bacteria other than MRSA; (2) allergy to first-line antibiotics; (3) immunosuppression; (4) splenectomy; (5) comorbidity; (6) ongoing antibiotic therapy or prophylaxis; (7) coexisting infection at another site; (8) previous surgery in the last month; and (9) presurgery hospitalization lasting more than 2 weeks. This work, made possible by the multidisciplinary contribution of experts belonging to the most important Italian scientific societies, represents, in our opinion, the most up-to-date and comprehensive collection of recommendations relating to behaviors to be undertaken in a perioperative site in the presence of specific categories of patients at high-risk of complications during surgery. The application of uniform and shared protocols in these high-risk categories will improve surgical practice with a reduction in SSIs and consequent rationalization of resources and costs, as well as being able to limit the phenomenon of antimicrobial resistance.
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- 2022
5. Netherton syndrome plus atopic dermatitis: Two new genetic mutations in the same patient
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Moar, Agata, primary, Bruni, Manfredo, additional, Schena, Donatella, additional, Rigotti, Erika, additional, Colato, Chiara, additional, Novelli, Antonio, additional, Cesario, Claudia, additional, and Girolomoni, Giampiero, additional
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- 2021
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6. Surgical Antimicrobial Prophylaxis in Neonates and Children Undergoing Neurosurgery: A RAND/UCLA Appropriateness Method Consensus Study.
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Esposito, Susanna, Zucchelli, Mino, Bianchini, Sonia, Nicoletti, Laura, Monaco, Sara, Rigotti, Erika, Venditto, Laura, Auriti, Cinzia, Caminiti, Caterina, Castagnola, Elio, Conti, Giorgio, De Luca, Maia, Donà, Daniele, Galli, Luisa, Garazzino, Silvia, La Grutta, Stefania, Lancella, Laura, Lima, Mario, Maglietta, Giuseppe, and Pelizzo, Gloria
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CRANIOTOMY ,NEUROSURGERY ,SURGICAL anastomosis ,SURGICAL site infections ,SPINAL surgery ,NEWBORN infants - Abstract
Pediatric neurosurgery is a highly specialized branch of surgery in which surgical site infections (SSIs) are potentially serious complications that can also adversely affect a good surgical outcome, compromising functional recovery and, in some cases, even putting the patient's life at risk. The main aim of this consensus document is to provide clinicians with a series of recommendations on antimicrobial prophylaxis for neonates and children undergoing neurosurgery. The following scenarios were considered: (1) craniotomy or cranial/cranio-facial approach to craniosynostosis; (2) neurosurgery with a trans-nasal-trans-sphenoidal approach; (3) non-penetrating head injuries; (4) penetrating head fracture; (5) spinal surgery (extradural and intradural); (6) shunt surgery or neuroendoscopy; (7) neuroendovascular procedures. Patients undergoing neurosurgery often undergo peri-operative antibiotic prophylaxis, with different schedules, not always supported by scientific evidence. This consensus provides clear and shared indications, based on the most updated literature. This work has been made possible by the multidisciplinary contribution of experts belonging to the most important Italian scientific societies, and represents, in our opinion, the most complete and up-to-date collection of recommendations on the behavior to be held in the peri-operative setting in this type of intervention, in order to guide physicians in the management of the patient, standardize approaches and avoid abuse and misuse of antibiotics. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Newborn Screening for Biotinidase Deficiency. The Experience of a Regional Center in Italy
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Maguolo, Alice, primary, Rodella, Giulia, additional, Dianin, Alice, additional, Monge, Irene, additional, Messina, Martina, additional, Rigotti, Erika, additional, Pellegrini, Francesca, additional, Molinaro, Grazia, additional, Lupi, Fiorenzo, additional, Pasini, Andrea, additional, Campostrini, Natascia, additional, Ion Popa, Florina, additional, Teofoli, Francesca, additional, Vincenzi, Monica, additional, Camilot, Marta, additional, Piacentini, Giorgio, additional, and Bordugo, Andrea, additional
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- 2021
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8. Surgical Antimicrobial Prophylaxis in Patients of Neonatal and Pediatric Age Subjected to Eye Surgery: A RAND/UCLA Appropriateness Method Consensus Study.
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Bianchini, Sonia, Morini, Chiara, Nicoletti, Laura, Monaco, Sara, Rigotti, Erika, Caminiti, Caterina, Conti, Giorgio, De Luca, Maia, Donà, Daniele, Maglietta, Giuseppe, Lancella, Laura, Lo Vecchio, Andrea, Marchini, Giorgio, Pietrasanta, Carlo, Principi, Nicola, Simonini, Alessandro, Venturini, Elisabetta, Longo, Rosa, Gusson, Elena, and Boccuzzi, Domenico
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OPHTHALMIC surgery ,NEONATAL surgery ,PEDIATRIC surgery ,CHILD patients ,SURGICAL site infections ,CORNEAL transplantation ,LACRIMAL apparatus - Abstract
Ocular surgery encompasses a wide range of procedures, including surgery of the tear ducts, eyelid, cornea and conjunctiva, lens, ocular muscle, and vitreoretinal and iris surgery. Operations are also performed for the removal of tumors, repairs of ocular trauma and, finally, corneal transplantation. Antibiotic prophylaxis for the prevention of surgical site infections (SSIs) in ocular surgery is a complex field in which shared lines of action are absent. In light of the scarcity of shared evidence in the use of ocular antimicrobial prophylaxis for the pediatric population, this consensus document aims to provide clinicians with a series of recommendations on antimicrobial prophylaxis for patients of neonatal and pediatric age undergoing eye surgery. The following scenarios are considered: (1) intraocular surgery; (2) extraocular surgery; (3) ocular trauma; (4) ocular neoplasm; (5) ocular surface transplantations; (6) corneal grafts. This work has been made possible by the multidisciplinary contribution of experts belonging to the most important Italian scientific societies and represents, in our opinion, the most complete and up-to-date collection of recommendations regarding clinical actions in the peri-operative environment in eye surgery. The application of uniform and shared protocols aims to improve surgical practice, through the standardization of procedures, with a consequent reduction of SSIs, also limiting the phenomenon of antimicrobial resistance. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Peri-Operative Prophylaxis in Patients of Neonatal and Pediatric Age Subjected to Cardiac and Thoracic Surgery: A RAND/UCLA Appropriateness Method Consensus Study.
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Bianchini, Sonia, Nicoletti, Laura, Monaco, Sara, Rigotti, Erika, Corbelli, Agnese, Colombari, Annamaria, Auriti, Cinzia, Caminiti, Caterina, Conti, Giorgio, De Luca, Maia, Donà, Daniele, Galli, Luisa, Garazzino, Silvia, Inserra, Alessandro, La Grutta, Stefania, Lancella, Laura, Lima, Mario, Lo Vecchio, Andrea, Pelizzo, Gloria, and Petrosillo, Nicola
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CARDIAC catheterization ,THORACIC surgery ,CARDIAC surgery ,VIDEO-assisted thoracic surgery ,CHILD patients ,SURGICAL site infections ,SURGICAL complications - Abstract
Surgical site infections (SSIs) represent a potential complication of surgical procedures, with a significant impact on mortality, morbidity, and healthcare costs. Patients undergoing cardiac surgery and thoracic surgery are often considered patients at high risk of developing SSIs. This consensus document aims to provide information on the management of peri-operative antibiotic prophylaxis for the pediatric and neonatal population undergoing cardiac and non-cardiac thoracic surgery. The following scenarios were considered: (1) cardiac surgery for the correction of congenital heart disease and/or valve surgery; (2) cardiac catheterization without the placement of prosthetic material; (3) cardiac catheterization with the placement of prosthetic material; (4) implantable cardiac defibrillator or epicardial pacemaker placement; (5) patients undergoing ExtraCorporal Membrane Oxygenation; (6) cardiac tumors and heart transplantation; (7) non-cardiac thoracic surgery with thoracotomy; (8) non-cardiac thoracic surgery using video-assisted thoracoscopy; (9) elective chest drain placement in the pediatric patient; (10) elective chest drain placement in the newborn; (11) thoracic drain placement in the trauma setting. This consensus provides clear and shared indications, representing the most complete and up-to-date collection of practice recommendations in pediatric cardiac and thoracic surgery, in order to guide physicians in the management of the patient, standardizing approaches and avoiding the abuse and misuse of antibiotics. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Surgical Antimicrobial Prophylaxis in Pediatric Patients Undergoing Plastic Surgery: A RAND/UCLA Appropriateness Method Consensus Study.
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Esposito, Susanna, Sgarzani, Rossella, Bianchini, Sonia, Monaco, Sara, Nicoletti, Laura, Rigotti, Erika, Di Pietro, Marilia, Opri, Roberta, Caminiti, Caterina, Ciccia, Matilde, Conti, Giorgio, Donà, Daniele, Giuffré, Mario, La Grutta, Stefania, Lancella, Laura, Lima, Mario, Lo Vecchio, Andrea, Pelizzo, Gloria, Piacentini, Giorgio, and Pietrasanta, Carlo
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PLASTIC surgery ,CHILD patients ,ANTIBIOTIC prophylaxis ,SURGICAL site infections ,ELECTIVE surgery ,BITES & stings - Abstract
For many years, it was clearly shown that surgical procedures might be associated with surgical site infection (SSI). Many scientific institutions prepared guidelines to use in surgery to reduce abuse and misuse of antibiotics. However, in the general guidelines for surgical antibiotic prophylaxis, plastic surgical procedures are not addressed or are only marginally discussed, and children were almost systematically excluded. The main aim of this Consensus document is to provide clinicians with recommendations on antimicrobial prophylaxis for pediatric patients undergoing plastic surgery. The following scenarios were considered: clean plastic surgery in elective procedures with an exclusive skin and subcutis involvement; clean-contaminated/contaminated plastic surgery in elective procedures with an exclusive skin and subcutis involvement; elective plastic surgery with use of local flaps; elective plastic surgery with the use of grafts; prolonged elective plastic surgery; acute burns; clean contused lacerated wounds without bone exposure; high-risk contused lacerated wounds or with bone exposure; contused lacerated wound involving the oral mucosa; plastic surgery following human bite; plastic surgery following animal bite; plastic surgery with tissue expander insertion. Our Consensus document shows that antimicrobial perioperative prophylaxis in pediatric patients undergoing plastic surgery is recommended in selected cases. While waiting the results of further pediatric studies, the application of uniform and shared protocols in these procedures will improve surgical practice, with a reduction in SSIs and consequent rationalization of resources and costs, as well as limiting the phenomenon of antimicrobial resistance. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Childhood obesity and SARS-CoV2: dangerous liaisons
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Ferruzzi, Alessandro, primary, Gasparini, Ludovico, additional, Pietrobelli, Angelo, additional, Denina, Marco, additional, Rigotti, Erika, additional, and Piacentini, Giorgio, additional
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- 2021
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12. Immune regulatory cytokines in the milk of lactating women from farming and urban environments
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Peroni, Diego G., Pescollderungg, Lydia, Piacentini, Giorgio L., Rigotti, Erika, Maselli, Mara, Watschinger, Katherina, Piazza, Michele, Pigozzi, Roberta, and Boner, Attilio L.
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- 2010
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13. Airway inflammation in elite swimmers
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Piacentini, Giorgio L., Rigotti, Erika, Bodini, Alessandro, Peroni, Diego, and Boner, Attilio L.
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- 2007
14. Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands
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Bortolus, Renata, Blom, Fenneke, Filippini, Francesca, van Poppel, Mireille N. M., Leoncini, Emanuele, de Smit, Denhard J., Benetollo, Pier P., Cornel, Martina C., de Walle, Hermien E. K., Mastroiacovo, Pierpaolo, Compagni, Alessandra, Rigotti, Erika, di Lannoy, Antonella Noya, Coati, Marilisa, Manfrè, Silvia, Barbazza, Roberto, Zanconato, Giovanni, Zenorini, Maria Teresa, Travagliati, Vittorio, Mantovani, Elena, Angeli, Anna, Cavaliere, Elena, Cherubini, Greta, Negretto, Alice, Lavarini, Elena, Ozzi, Milena, Papadopoulos, Nikolaos, Di Mambro, Enrico, Vessella, Maddalena, Ettore, Giuseppe, Bianca, Sebastiano, Barone, Chiara, Cosmi, Erich, Visentin, Silvia, Camerin, Martina, Lanza, Paola, Marinangeli, Simonetta, Negrini, Giorgia, Ottaviani, Alberto, Zivelonghi, Laura, Baffoni, Andrea, Bertezzolo, Michaela, Pistolato, Mara, Ioverno, Enrico, Somigliana, Edgardo, Scarduelli, Claudia, Alagna, Federica, Santi, Giulia, Cesari, Elena, Zanini, Paola, Morandini, Achille, Cetin, Irene, Laoreti, Arianna, Tresso, Chiara, Grazia Salviato, Maria, Matterazzo, Marina, Failli, Carlo, Marzolini, Maurizia, Casaro, Anna, Balestreri, Debora, Benassi, Elena, Caloi, Elisa, Libero Giorgino, Francesco, Schiavo, Alessandra, Pietro Piazza, Gian, Ruffini, Renato, Jorizzo, Gianfranco, Cirelli, Gaetana, Arcidiacono, Francesca, De Toni, Anna, Rusconi, Silvia, Guaraldi, Claudia, Rosi, Patrizia, Mortaro, Graziella, Valotto, Laura, Guido, Angelo, Zanni, Giuliano, Vernier, Chiara, Sandri, Anna, Minisci, Nedelia, Human genetics, Public and occupational health, and EMGO - Quality of care
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Counseling ,Pediatrics ,Folic acid ,HEART-DEFECTS ,Severity of Illness Index ,Miscarriage ,law.invention ,Study Protocol ,Randomized controlled trial ,law ,Pregnancy ,Obstetrics and Gynaecology ,Community Health Services ,Netherlands ,Congenital malformations ,Obstetrics ,Medicine (all) ,Pregnancy Outcome ,Obstetrics and Gynecology ,Prenatal Care ,Vitamins ,Middle Aged ,MATERNAL SERUM FOLATE ,Italy ,Research Design ,Meta-analysis ,Vitamin B Complex ,Female ,NEURAL-TUBE DEFECTS ,Preconception Care ,Birth defects ,Birth weight ,Pre-eclampsia ,Prematurity ,Prevention ,Adolescent ,Adult ,Congenital Abnormalities ,Dietary Supplements ,Folic Acid ,Humans ,Pregnancy Complications ,Young Adult ,medicine.medical_specialty ,PRETERM BIRTH ,FOOD FORTIFICATION ,Prenatal care ,medicine ,GESTATIONAL-AGE BIRTHS ,business.industry ,PERICONCEPTIONAL MULTIVITAMIN USE ,OROFACIAL CLEFTS ,medicine.disease ,MOTHER-CHILD COHORT ,Small for gestational age ,FETAL-GROWTH ,Observational study ,business - Abstract
In 2010 a Cochrane review confirmed that folic acid (FA) supplementation prevents the first- and second-time occurrence of neural tube defects (NTDs). At present some evidence from observational studies supports the hypothesis that FA supplementation can reduce the risk of all congenital malformations (CMs) or the risk of a specific and selected group of them, namely cardiac defects and oral clefts. Furthermore, the effects on the prevention of prematurity, foetal growth retardation and pre-eclampsia are unclear. Although the most common recommendation is to take 0.4 mg/day, the problem of the most appropriate dose of FA is still open. The aim of this project is to assess the effect a higher dose of peri-conceptional FA supplementation on reducing the occurrence of all CMs. Other aims include the promotion of pre-conceptional counselling, comparing rates of selected CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age, abruptio placentae. This project is a joint effort by research groups in Italy and the Netherlands. Women of childbearing age, who intend to become pregnant within 12 months are eligible for the studies. Women are randomly assigned to receive 4 mg of FA (treatment in study) or 0.4 mg of FA (referent treatment) daily. Information on pregnancy outcomes are derived from women-and-physician information. We foresee to analyze the data considering all the adverse outcomes of pregnancy taken together in a global end point (e.g.: CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age). A total of about 1,000 pregnancies need to be evaluated to detect an absolute reduction of the frequency of 8%. Since the sample size needed for studying outcomes separately is large, this project also promotes an international prospective meta-analysis. The rationale of these randomized clinical trials (RCTs) is the hypothesis that a higher intake of FA is related to a higher risk reduction of NTDs, other CMs and other adverse pregnancy outcomes. Our hope is that these trials will act as catalysers, and lead to other large RCTs studying the effects of this supplementation on CMs and other infant and maternal outcomes. Italian trial: ClinicalTrials.gov Identifier: NCT01244347 . Dutch trial: Dutch Trial Register ID: NTR3161 .
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- 2014
15. Nasal nitric oxide for early diagnosis of primary ciliary dyskinesia: Practical issues in children
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Piacentini, Giorgio L., primary, Bodini, Alessandro, additional, Peroni, Diego, additional, Rigotti, Erika, additional, Pigozzi, Roberta, additional, Pradal, Ugo, additional, and Boner, Attilio L., additional
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- 2008
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16. Antimicrobial Prophylaxis in Neonates and Children Undergoing Dental, Maxillo-Facial or Ear-Nose-Throat (ENT) Surgery: A RAND/UCLA Appropriateness Method Consensus Study.
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Rigotti, Erika, Bianchini, Sonia, Nicoletti, Laura, Monaco, Sara, Carrara, Elena, Opri, Francesca, Opri, Roberta, Caminiti, Caterina, Donà, Daniele, Giuffré, Mario, Inserra, Alessandro, Lancella, Laura, Mugelli, Alessandro, Piacentini, Giorgio, Principi, Nicola, Tesoro, Simonetta, Venturini, Elisabetta, Staiano, Annamaria, Villani, Alberto, and Sesenna, Enrico
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PALATE surgery ,SURGICAL site infections ,NEWBORN infants ,OPERATIVE dentistry ,CLEFT palate ,CLEFT lip - Abstract
Surgical site infections (SSIs) represent a potential complication in surgical procedures, mainly because clean/contaminated surgery involves organs that are normally colonized by bacteria. Dental, maxillo-facial and ear-nose-throat (ENT) surgeries are among those that carry a risk of SSIs because the mouth and the first respiratory tracts are normally colonized by a bacterial flora. The aim of this consensus document was to provide clinicians with recommendations on surgical antimicrobial prophylaxis in neonates (<28 days of chronological age) and pediatric patients (within the age range of 29 days–18 years) undergoing dental, maxillo-facial or ENT surgical procedures. These included: (1) dental surgery; (2) maxilla-facial surgery following trauma with fracture; (3) temporo-mandibular surgery; (4) cleft palate and cleft lip repair; (5) ear surgery; (6) endoscopic paranasal cavity surgery and septoplasty; (7) clean head and neck surgery; (8) clean/contaminated head and neck surgery and (9) tonsillectomy and adenoidectomy. Due to the lack of pediatric data for the majority of dental, maxillo-facial and ENT surgeries and the fact that the recommendations for adults are currently used, there is a need for ad hoc studies to be rapidly planned for the most deficient areas. This seems even more urgent for interventions such as those involving the first airways since the different composition of the respiratory microbiota in children compared to adults implies the possibility that surgical antibiotic prophylaxis schemes that are ideal for adults may not be equally effective in children. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Antimicrobial Prophylaxis for Urologic Procedures in Paediatric Patients: A RAND/UCLA Appropriateness Method Consensus Study in Italy.
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Esposito, Susanna, Rigotti, Erika, Argentiero, Alberto, Caminiti, Caterina, Castagnola, Elio, Lancella, Laura, Venturini, Elisabetta, De Luca, Maia, La Grutta, Stefania, Lima, Mario, Tesoro, Simonetta, Ciccia, Matilde, Staiano, Annamaria, Autore, Giovanni, Piacentini, Giorgio, and Principi, Nicola
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CHILD patients ,URINARY tract infections ,HERNIA surgery ,SURGICAL site infections ,PEDIATRIC urology - Abstract
The main aim of surgical antimicrobial prophylaxis (SAP) in urologic procedures is to prevent bacteraemia, surgical site infections (SSIs), and postoperative urinary tract infections (ppUTIs). Guidelines for SAP in paediatric urology are lacking. Only some aspects of this complex topic have been studied, and the use of antibiotic prophylaxis prior to surgical procedures seems to be more often linked to institutional schools of thought or experts' opinions than to rules dictated by studies demonstrating the most correct and preferred management. Therefore, the aim of this Consensus document realized using the RAND/UCLA appropriateness method is to provide clinicians with a series of recommendations on SAP for the prevention of bacteraemia, SSIs, and ppUTIs after urologic imaging and surgical procedures in paediatric patients. Despite the few available studies, experts agree on some basilar concepts related to SAP for urologic procedures in paediatric patients. Before any urological procedure is conducted, UTI must be excluded. Clean procedures do not require SAP, with the exception of prosthetic device implantation and groin and perineal incisions where the SSI risk may be increased. In contrast, SAP is needed in clean-contaminated procedures. Studies have also suggested the safety of eliminating SAP in paediatric hernia repair and orchiopexy. To limit the emergence of resistance, every effort to reduce and rationalize antibiotic consumption for SAP must be made. Increased use of antibiotic stewardship can be greatly effective in this regard. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Surgical Antimicrobial Prophylaxis in Patients of Neonatal and Pediatric Age Undergoing Orthopedic and Hand Surgery: A RAND/UCLA Appropriateness Method Consensus Study.
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Opri, Francesca, Bianchini, Sonia, Nicoletti, Laura, Monaco, Sara, Opri, Roberta, Di Pietro, Marilia, Carrara, Elena, Rigotti, Erika, Auriti, Cinzia, Caminiti, Caterina, Donà, Daniele, Lancella, Laura, Lo Vecchio, Andrea, Pizzi, Simone, Principi, Nicola, Simonini, Alessandro, Tesoro, Simonetta, Venturini, Eisabetta, Villani, Alberto, and Staiano, Annamaria
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ORTHOPEDIC surgery ,ANTIBIOTIC prophylaxis ,PEDIATRIC surgery ,ELECTIVE surgery ,CHILD patients ,MEDICAL personnel ,SPINAL surgery - Abstract
Surgical site infections (SSIs) represent a potential complication in any type of surgery and can occur up to one year after the procedure in the case of implant placement. In the field of orthopedic and hand surgery, the rate of SSIs is a relevant issue, considering the need for the placement of synthesis devices and the type of some interventions (e.g., exposed fractures). This work aims to provide guidance on the management of peri-operative antibiotic prophylaxis for the pediatric and neonatal population undergoing orthopedic and hand surgery in order to standardize the management of patients and to reduce, on the one hand, the risk of SSI and, on the other, the development of antimicrobial resistance. The following scenarios were considered: (1) bloodless fracture reduction; (2) reduction of unexposed fracture and grade I and II exposed fracture; (3) reduction of grade III exposed fracture or traumatic amputation; (4) cruel fracture reduction with percutaneous synthesis; (5) non-traumatic amputation; (6) emergency intact skin trauma surgery and elective surgery without synthetic media placement; (7) elective orthopedic surgery with prosthetic and/or synthetic media placement and spinal surgery; (8) clean elective hand surgery with and without bone involvement, without use of synthetic means; (9) surgery of the hand on an elective basis with bone involvement and/or with use of synthetic means. This manuscript has been made possible by the multidisciplinary contribution of experts belonging to the most important Italian scientific societies and represents, in our opinion, the most complete and up-to-date collection of recommendations regarding the behavior to be adopted in the peri-operative setting in neonatal and pediatric orthopedic and hand surgery. The specific scenarios developed are aimed at guiding the healthcare professional in practice to ensure the better and standardized management of neonatal and pediatric patients, together with an easy consultation. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Update on the use of montelukast in pediatric asthma.
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Capristo, Carlo, Rigotti, Erika, and Boner, Attilio L.
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ASTHMA ,JUVENILE diseases ,PHENOTYPES ,PEDIATRICS ,PLACEBOS ,DRUGS - Abstract
Cysteinyl leukotrienes are inflammatory bioactive lipids produced by various cells. They are present in increased amounts in airway secretions of all different asthma phenotypes and can induce all the inflammatory changes observed in the airways of asthmatic patients. For this reason, an attempt to inhibit the actions of these mediators through the use of cysteinyl receptor antagonists appears rational. Montelukast belongs to this new class of drugs, which has been proved effective in asthmatic children and its safety profile is comparable with that of placebo. The major advantages of this drug are its once-daily oral administration, which increases adherence to the therapeutic regimen; its long-term persistent efficacy in the prevention of exercise-induced bronchoconstriction; its possible preventive activity on viral-induced asthma exacerbations; and its complementary and additive effects when used with inhaled corticosteroids. As established for all drugs commonly used in the treatment of asthma, there is an interindividual variability also in response to montelukast. Therefore, it is important that caregivers evaluate treatment effect objectively in every asthmatic child to provide the single patient with a therapeutic regimen allowing the best quality of life. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
20. Surgical Antimicrobial Prophylaxis in Neonates and Children Undergoing Neurosurgery: A RAND/UCLA Appropriateness Method Consensus Study
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Susanna, Esposito, Mino, Zucchelli, Sonia, Bianchini, Laura, Nicoletti, Sara, Monaco, Erika, Rigotti, Laura, Venditto, Cinzia, Auriti, Caterina, Caminiti, Elio, Castagnola, Giorgio, Conti, Maia, De Luca, Daniele, Donà, Luisa, Galli, Silvia, Garazzino, Stefania, La Grutta, Laura, Lancella, Mario, Lima, Giuseppe, Maglietta, Gloria, Pelizzo, Nicola, Petrosillo, Giorgio, Piacentini, Simone, Pizzi, Alessandro, Simonini, Simonetta, Tesoro, Elisabetta, Venturini, Fabio, Mosca, Annamaria, Staiano, Nicola, Principi, On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Esposito, Susanna, Zucchelli, Mino, Bianchini, Sonia, Nicoletti, Laura, Monaco, Sara, Rigotti, Erika, Venditto, Laura, Auriti, Cinzia, Caminiti, Caterina, Castagnola, Elio, Conti, Giorgio, De Luca, Maia, Donà, Daniele, Galli, Luisa, Garazzino, Silvia, La Grutta, Stefania, Lancella, Laura, Lima, Mario, Maglietta, Giuseppe, Pelizzo, Gloria, Petrosillo, Nicola, Piacentini, Giorgio, Pizzi, Simone, Simonini, Alessandro, Tesoro, Simonetta, Venturini, Elisabetta, Mosca, Fabio, Staiano, Annamaria, Principi, Nicola, and On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Null
- Subjects
Microbiology (medical) ,craniotomy ,Biochemistry ,Microbiology ,pediatric infectious disease ,Infectious Diseases ,surgical antibiotic prophylaxis ,antibiotics ,head fracture ,pediatric infectious diseases ,neurosurgery ,antibiotic ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,Keywords: antibiotic - Abstract
Pediatric neurosurgery is a highly specialized branch of surgery in which surgical site infections (SSIs) are potentially serious complications that can also adversely affect a good surgical outcome, compromising functional recovery and, in some cases, even putting the patient’s life at risk. The main aim of this consensus document is to provide clinicians with a series of recommendations on antimicrobial prophylaxis for neonates and children undergoing neurosurgery. The following scenarios were considered: (1) craniotomy or cranial/cranio-facial approach to craniosynostosis; (2) neurosurgery with a trans-nasal-trans-sphenoidal approach; (3) non-penetrating head injuries; (4) penetrating head fracture; (5) spinal surgery (extradural and intradural); (6) shunt surgery or neuroendoscopy; (7) neuroendovascular procedures. Patients undergoing neurosurgery often undergo peri-operative antibiotic prophylaxis, with different schedules, not always supported by scientific evidence. This consensus provides clear and shared indications, based on the most updated literature. This work has been made possible by the multidisciplinary contribution of experts belonging to the most important Italian scientific societies, and represents, in our opinion, the most complete and up-to-date collection of recommendations on the behavior to be held in the peri-operative setting in this type of intervention, in order to guide physicians in the management of the patient, standardize approaches and avoid abuse and misuse of antibiotics.
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- 2022
21. Peri-Operative Prophylaxis in Patients of Neonatal and Pediatric Age Subjected to Cardiac and Thoracic Surgery: A RAND/UCLA Appropriateness Method Consensus Study
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Sonia, Bianchini, Laura, Nicoletti, Sara, Monaco, Erika, Rigotti, Agnese, Corbelli, Annamaria, Colombari, Cinzia, Auriti, Caterina, Caminiti, Giorgio, Conti, Maia, De Luca, Daniele, Donà, Luisa, Galli, Silvia, Garazzino, Alessandro, Inserra, Stefania, La Grutta, Laura, Lancella, Mario, Lima, Andrea, Lo Vecchio, Gloria, Pelizzo, Nicola, Petrosillo, Giorgio, Piacentini, Carlo, Pietrasanta, Nicola, Principi, Matteo, Puntoni, Alessandro, Simonini, Simonetta, Tesoro, Elisabetta, Venturini, Annamaria, Staiano, Fabio, Caramelli, Gaetano Domenico, Gargiulo, Susanna, Esposito, On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Bianchini, Sonia, Nicoletti, Laura, Monaco, Sara, Rigotti, Erika, Corbelli, Agnese, Colombari, Annamaria, Auriti, Cinzia, Caminiti, Caterina, Conti, Giorgio, De Luca, Maia, Donà, Daniele, Galli, Luisa, Garazzino, Silvia, Inserra, Alessandro, La Grutta, Stefania, Lancella, Laura, Lima, Mario, Lo Vecchio, Andrea, Pelizzo, Gloria, Petrosillo, Nicola, Piacentini, Giorgio, Pietrasanta, Carlo, Principi, Nicola, Puntoni, Matteo, Simonini, Alessandro, Tesoro, Simonetta, Venturini, Elisabetta, Staiano, Annamaria, Caramelli, Fabio, Gargiulo, Gaetano, Esposito, Susanna, Bianchini, S., Nicoletti, L., Monaco, S., Rigotti, E., Corbelli, A., Colombari, A., Auriti, C., Caminiti, C., Conti, G., De Luca, M., Dona, D., Galli, L., Garazzino, S., Inserra, A., La Grutta, S., Lancella, L., Lima, M., Lo Vecchio, A., Pelizzo, G., Petrosillo, N., Piacentini, G., Pietrasanta, C., Principi, N., Puntoni, M., Simonini, A., Tesoro, S., Venturini, E., Staiano, A., Caramelli, F., Gargiulo, G. D., and Esposito, S.
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Settore MED/38 - Pediatria Generale e Specialistica ,Microbiology (medical) ,Biochemistry ,Microbiology ,thoracic surgery ,antibiotics ,pediatric infectious disease ,Infectious Diseases ,surgical antibiotic prophylaxis ,antibiotic ,Settore MED/41 - ANESTESIOLOGIA ,surgical antibiotic prophylaxi ,Pharmacology (medical) ,cardiac surgery ,ECMO ,pediatric infectious diseases ,General Pharmacology, Toxicology and Pharmaceutics ,Keywords: antibiotic - Abstract
Surgical site infections (SSIs) represent a potential complication of surgical procedures, with a significant impact on mortality, morbidity, and healthcare costs. Patients undergoing cardiac surgery and thoracic surgery are often considered patients at high risk of developing SSIs. This consensus document aims to provide information on the management of peri-operative antibiotic prophylaxis for the pediatric and neonatal population undergoing cardiac and non-cardiac thoracic surgery. The following scenarios were considered: (1) cardiac surgery for the correction of congenital heart disease and/or valve surgery; (2) cardiac catheterization without the placement of prosthetic material; (3) cardiac catheterization with the placement of prosthetic material; (4) implantable cardiac defibrillator or epicardial pacemaker placement; (5) patients undergoing ExtraCorporal Membrane Oxygenation; (6) cardiac tumors and heart transplantation; (7) non-cardiac thoracic surgery with thoracotomy; (8) non-cardiac thoracic surgery using video-assisted thoracoscopy; (9) elective chest drain placement in the pediatric patient; (10) elective chest drain placement in the newborn; (11) thoracic drain placement in the trauma setting. This consensus provides clear and shared indications, representing the most complete and up-to-date collection of practice recommendations in pediatric cardiac and thoracic surgery, in order to guide physicians in the management of the patient, standardizing approaches and avoiding the abuse and misuse of antibiotics.
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- 2022
22. Surgical Antimicrobial Prophylaxis in Pediatric Patients Undergoing Plastic Surgery: A RAND/UCLA Appropriateness Method Consensus Study
- Author
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Esposito S, Sgarzani R, Bianchini S, Monaco S, Nicoletti L, Rigotti E, Di Pietro M, Opri R, Caminiti C, Ciccia M, Conti G, Donà D, Giuffré M, La Grutta S, Lancella L, Lima M, Lo Vecchio A, Pelizzo G, Piacentini G, Pietrasanta C, Puntoni M, Simonini A, Venturini E, Staiano A, Principi N, On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group., Esposito S., Sgarzani R., Bianchini S., Monaco S., Nicoletti L., Rigotti E., Di Pietro M., Opri R., Caminiti C., Ciccia M., Conti G., Dona D., Giuffre M., La Grutta S., Lancella L., Lima M., Vecchio A.L., Pelizzo G., Piacentini G., Pietrasanta C., Puntoni M., Simonini A., Venturini E., Staiano A., Principi N., Esposito, Susanna, Sgarzani, Rossella, Bianchini, Sonia, Monaco, Sara, Nicoletti, Laura, Rigotti, Erika, Di Pietro, Marilia, Opri, Roberta, Caminiti, Caterina, Ciccia, Matilde, Conti, Giorgio, Donà, Daniele, Giuffré, Mario, La Grutta, Stefania, Lancella, Laura, Lima, Mario, Lo Vecchio, Andrea, Pelizzo, Gloria, Piacentini, Giorgio, Pietrasanta, Carlo, Puntoni, Matteo, Simonini, Alessandro, Venturini, Elisabetta, Staiano, Annamaria, and Principi, Nicola
- Subjects
Microbiology (medical) ,Settore MED/38 - Pediatria Generale e Specialistica ,wound ,Biochemistry ,Microbiology ,antibiotics ,burn ,pediatric infectious diseases ,plastic surgery ,surgical antibiotic prophylaxis ,pediatric infectious disease ,Infectious Diseases ,antibiotic ,Pharmacology (medical) ,surgical antibiotic prophylaxi ,General Pharmacology, Toxicology and Pharmaceutics ,Keywords: antibiotic - Abstract
For many years, it was clearly shown that surgical procedures might be associated with surgical site infection (SSI). Many scientific institutions prepared guidelines to use in surgery to reduce abuse and misuse of antibiotics. However, in the general guidelines for surgical antibiotic prophylaxis, plastic surgical procedures are not addressed or are only marginally discussed, and children were almost systematically excluded. The main aim of this Consensus document is to provide clinicians with recommendations on antimicrobial prophylaxis for pediatric patients undergoing plastic surgery. The following scenarios were considered: clean plastic surgery in elective procedures with an exclusive skin and subcutis involvement; clean-contaminated/contaminated plastic surgery in elective procedures with an exclusive skin and subcutis involvement; elective plastic surgery with use of local flaps; elective plastic surgery with the use of grafts; prolonged elective plastic surgery; acute burns; clean contused lacerated wounds without bone exposure; high-risk contused lacerated wounds or with bone exposure; contused lacerated wound involving the oral mucosa; plastic surgery following human bite; plastic surgery following animal bite; plastic surgery with tissue expander insertion. Our Consensus document shows that antimicrobial perioperative prophylaxis in pediatric patients undergoing plastic surgery is recommended in selected cases. While waiting the results of further pediatric studies, the application of uniform and shared protocols in these procedures will improve surgical practice, with a reduction in SSIs and consequent rationalization of resources and costs, as well as limiting the phenomenon of antimicrobial resistance.
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- 2022
23. Surgical Antimicrobial Prophylaxis in Patients of Neonatal and Pediatric Age Subjected to Eye Surgery: A RAND/UCLA Appropriateness Method Consensus Study
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Sonia, Bianchini, Chiara, Morini, Laura, Nicoletti, Sara, Monaco, Erika, Rigotti, Caterina, Caminiti, Giorgio, Conti, Maia, De Luca, Daniele, Donà, Giuseppe, Maglietta, Laura, Lancella, Andrea, Lo Vecchio, Giorgio, Marchini, Carlo, Pietrasanta, Nicola, Principi, Alessandro, Simonini, Elisabetta, Venturini, Rosa, Longo, Elena, Gusson, Domenico, Boccuzzi, Luca, Vigo, Fabio, Mosca, Annamaria, Staiano, Susanna, Esposito, On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Bianchini, Sonia, Morini, Chiara, Nicoletti, Laura, Monaco, Sara, Rigotti, Erika, Caminiti, Caterina, Conti, Giorgio, De Luca, Maia, Donà, Daniele, Maglietta, Giuseppe, Lancella, Laura, Lo Vecchio, Andrea, Marchini, Giorgio, Pietrasanta, Carlo, Principi, Nicola, Simonini, Alessandro, Venturini, Elisabetta, Longo, Rosa, Gusson, Elena, Boccuzzi, Domenico, Vigo, Luca, Mosca, Fabio, Staiano, Annamaria, Esposito, Susanna, and On Behalf Of The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Null
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Microbiology (medical) ,Settore MED/38 - Pediatria Generale e Specialistica ,genetic structures ,antibiotics ,eye ,pediatric infectious diseases ,pediatric ophthalmology ,ocular surgery ,surgical antimicrobial prophylaxis ,Biochemistry ,Microbiology ,eye diseases ,pediatric infectious disease ,Infectious Diseases ,Antibiotics ,antibiotic ,Settore MED/41 - ANESTESIOLOGIA ,Pharmacology (medical) ,sense organs ,General Pharmacology, Toxicology and Pharmaceutics - Abstract
Ocular surgery encompasses a wide range of procedures, including surgery of the tear ducts, eyelid, cornea and conjunctiva, lens, ocular muscle, and vitreoretinal and iris surgery. Operations are also performed for the removal of tumors, repairs of ocular trauma and, finally, corneal transplantation. Antibiotic prophylaxis for the prevention of surgical site infections (SSIs) in ocular surgery is a complex field in which shared lines of action are absent. In light of the scarcity of shared evidence in the use of ocular antimicrobial prophylaxis for the pediatric population, this consensus document aims to provide clinicians with a series of recommendations on antimicrobial prophylaxis for patients of neonatal and pediatric age undergoing eye surgery. The following scenarios are considered: (1) intraocular surgery; (2) extraocular surgery; (3) ocular trauma; (4) ocular neoplasm; (5) ocular surface transplantations; (6) corneal grafts. This work has been made possible by the multidisciplinary contribution of experts belonging to the most important Italian scientific societies and represents, in our opinion, the most complete and up-to-date collection of recommendations regarding clinical actions in the peri-operative environment in eye surgery. The application of uniform and shared protocols aims to improve surgical practice, through the standardization of procedures, with a consequent reduction of SSIs, also limiting the phenomenon of antimicrobial resistance.
- Published
- 2022
24. Antimicrobial Prophylaxis for Urologic Procedures in Paediatric Patients: A RAND/UCLA Appropriateness Method Consensus Study in Italy
- Author
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Susanna, Esposito, Erika, Rigotti, Alberto, Argentiero, Caterina, Caminiti, Elio, Castagnola, Laura, Lancella, Elisabetta, Venturini, Maia, De Luca, Stefania, La Grutta, Mario, Lima, Simonetta, Tesoro, Matilde, Ciccia, Annamaria, Staiano, Giovanni, Autore, Giorgio, Piacentini, Nicola, Principi, The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group, Esposito, Susanna, Rigotti, Erika, Argentiero, Alberto, Caminiti, Caterina, Castagnola, Elio, Lancella, Laura, Venturini, Elisabetta, De Luca, Maia, La Grutta, Stefania, Lima, Mario, Tesoro, Simonetta, Ciccia, Matilde, Staiano, Annamaria, Autore, Giovanni, Piacentini, Giorgio, and Principi, Nicola
- Subjects
Microbiology (medical) ,hypospadia ,kidney transplantation ,RAND/UCLA method ,surgical antimicrobial prophylaxis ,Biochemistry ,Microbiology ,nephrolithiasi ,Infectious Diseases ,surgical antimicrobial prophylaxi ,cystoscopy ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,hypospadias ,urology ,nephrolithiasis - Abstract
The main aim of surgical antimicrobial prophylaxis (SAP) in urologic procedures is to prevent bacteraemia, surgical site infections (SSIs), and postoperative urinary tract infections (ppUTIs). Guidelines for SAP in paediatric urology are lacking. Only some aspects of this complex topic have been studied, and the use of antibiotic prophylaxis prior to surgical procedures seems to be more often linked to institutional schools of thought or experts’ opinions than to rules dictated by studies demonstrating the most correct and preferred management. Therefore, the aim of this Consensus document realized using the RAND/UCLA appropriateness method is to provide clinicians with a series of recommendations on SAP for the prevention of bacteraemia, SSIs, and ppUTIs after urologic imaging and surgical procedures in paediatric patients. Despite the few available studies, experts agree on some basilar concepts related to SAP for urologic procedures in paediatric patients. Before any urological procedure is conducted, UTI must be excluded. Clean procedures do not require SAP, with the exception of prosthetic device implantation and groin and perineal incisions where the SSI risk may be increased. In contrast, SAP is needed in clean-contaminated procedures. Studies have also suggested the safety of eliminating SAP in paediatric hernia repair and orchiopexy. To limit the emergence of resistance, every effort to reduce and rationalize antibiotic consumption for SAP must be made. Increased use of antibiotic stewardship can be greatly effective in this regard.
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- 2022
25. Surgical Antimicrobial Prophylaxis in Abdominal Surgery for Neonates and Paediatrics: A RAND/UCLA Appropriateness Method Consensus Study.
- Author
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Bianchini S, Rigotti E, Monaco S, Nicoletti L, Auriti C, Castagnola E, Conti G, Galli L, Giuffrè M, La Grutta S, Lancella L, Lo Vecchio A, Maglietta G, Petrosillo N, Pietrasanta C, Principi N, Tesoro S, Venturini E, Piacentini G, Lima M, Staiano A, Esposito S, and The Peri-Operative Prophylaxis In Neonatal And Paediatric Age Pop-NeoPed Study Group
- Abstract
Surgical site infections (SSIs), i.e., surgery-related infections that occur within 30 days after surgery without an implant and within one year if an implant is placed, complicate surgical procedures in up to 10% of cases, but an underestimation of the data is possible since about 50% of SSIs occur after the hospital discharge. Gastrointestinal surgical procedures are among the surgical procedures with the highest risk of SSIs, especially when colon surgery is considered. Data that were collected from children seem to indicate that the risk of SSIs can be higher than in adults. This consensus document describes the use of preoperative antibiotic prophylaxis in neonates and children that are undergoing abdominal surgery and has the purpose of providing guidance to healthcare professionals who take care of children to avoid unnecessary and dangerous use of antibiotics in these patients. The following surgical procedures were analyzed: (1) gastrointestinal endoscopy; (2) abdominal surgery with a laparoscopic or laparotomy approach; (3) small bowel surgery; (4) appendectomy; (5) abdominal wall defect correction interventions; (6) ileo-colic perforation; (7) colorectal procedures; (8) biliary tract procedures; and (9) surgery on the liver or pancreas. Thanks to the multidisciplinary contribution of experts belonging to the most important Italian scientific societies that take care of neonates and children, this document presents an invaluable reference tool for perioperative antibiotic prophylaxis in the paediatric and neonatal populations.
- Published
- 2022
- Full Text
- View/download PDF
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