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16. Exploration of Efficient HLA Haplotypes by Comparing the Proportion of Applicable Populations.

Author

Sunwoong, Paeng, Rim, Yeri Alice, Sohn, Yeowon, Nam, Yoojun, and Ju, Ji Hyeon

Subjects
HLA histocompatibility antigens, PLURIPOTENT stem cells, CELLULAR therapy, OLDER people, HAPLOTYPES
Abstract

With the aging population, the incidence of degenerative diseases such as dementia and arthritis is on the rise. To combat these diseases, cell therapies using induced pluripotent stem cells (iPSCs) are being developed worldwide. However, challenges such as high development costs and immune compatibility persist. Thus, methods such as generating patient-specific iPSCs or genetically edited iPSCs with deleted immune-related genes are being researched. Applying these approaches is limited due to high cost and safety concerns of gene editing. Therefore, we focused on an alternative method using human leukocyte antigen (HLA)-homozygous cell lines, which could overcome immune rejection issues economically. We investigated diseases that could potentially be treated with cell therapy and identified which HLA-homozygous cell lines could be most effectively used for the efficient production of therapeutic cell lines. The results of the study showed that cell therapy could be applied to a wide range of diseases, and expanding the population that can benefit from HLA-homozygous iPSC lines could help popularize these treatment methods. We highlight the necessity of a global HLA-homozygous iPSC bank. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Promoting Long‐Term Cultivation of Motor Neurons for 3D Neuromuscular Junction Formation of 3D In Vitro Using Central‐Nervous‐Tissue‐Derived Bioink

Author

Kong, Jeong Sik, primary, Huang, Xuan, additional, Choi, Yeong‐Jin, additional, Yi, Hee‐Gyeong, additional, Kang, Junsu, additional, Kim, Sejin, additional, Kim, Jongmin, additional, Lee, Hyungseok, additional, Rim, Yeri Alice, additional, Ju, Ji Hyeon, additional, Chung, Wan Kyun, additional, Woolf, Clifford J., additional, Jang, Jinah, additional, and Cho, Dong‐Woo, additional

Published
2021
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38. Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration

Author

Nam, Yoojun, Rim, Yeri Alice, Lee, Jennifer, and Ju, Ji Hyeon

Subjects
Article Subject
Abstract

The process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes uncontrollable or joint function completely fails. There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy. Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues. Cartilage may be an ideal target for stem cell treatment because it has a notoriously poor regenerative potential. In this review, we describe past, present, and future strategies to regenerate cartilage in patients. Specifically, this review compares a surgical regenerative technique (microfracture) and cell therapy, cell therapy with and without a scaffold, and therapy with nonaggregated and aggregated cells. We also review the chondrogenic potential of cells according to their origin, including autologous chondrocytes, mesenchymal stem cells, and induced pluripotent stem cells.

Published
2018
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39. Sodium Chloride Aggravates Arthritis via Th17 Polarization

Author

Jung, Seung Min, primary, Kim, Youngkyun, additional, Kim, Juryun, additional, Jung, Hyerin, additional, Yi, Hyoju, additional, Rim, Yeri Alice, additional, Park, Narae, additional, Kwok, Seung-Ki, additional, Park, Sung-Hwan, additional, and Ju, Ji Hyeon, additional

Published
2019
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45. Interrupting oral infection of Porphyromonas gingivalis with anti-FimA antibody attenuates bacterial dissemination to the arthritic joint and improves experimental arthritis

Author

Jeong, Sang Hoon, primary, Nam, Yoojun, additional, Jung, Hyerin, additional, Kim, Juryun, additional, Rim, Yeri Alice, additional, Park, Narae, additional, Lee, Kijun, additional, Choi, Seungjin, additional, Jang, Yeonsue, additional, Kim, Yena, additional, Moon, Ji-Hoi, additional, Jung, Seung Min, additional, Park, Sung-Hwan, additional, and Ju, Ji Hyeon, additional

Published
2018
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49. Recent progress of national banking project on homozygous HLA ‐typed induced pluripotent stem cells in S outh K orea

Author

Rim, Yeri Alice, primary, Park, Narae, additional, Nam, Yoojun, additional, Ham, Dong‐Sik, additional, Kim, Ji‐Won, additional, Ha, Hye‐Yeong, additional, Jung, Ji‐Won, additional, Jung, Seung Min, additional, Baek, In Cheol, additional, Kim, Su‐Yeon, additional, Kim, Tai‐Gyu, additional, Song, Jihwan, additional, Lee, Jennifer, additional, Park, Sung‐Hwan, additional, Chung, Nak‐Gyun, additional, Yoon, Kun‐Ho, additional, and Ju, Ji Hyeon, additional

Published
2017
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