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Hyperglycemia and abnormal BMI are possible signs of metabolic disease. Diabetes mellitus is a disease of glucose metabolic disorders in which the body cannot or is not good at controlling the glucose that enters from food so that blood sugar levels are high. This study aims to determine the relationship between long suffering from type 2 diabetes mellitus and blood sugar levels with body mass index (BMI) in type 2 diabetes mellitus patients at Pertamina Bintang Amin Husada Hospital Bandar Lampung in 2021. This study used an observational analytic method and a cross sectional approach. It was found that the results of statistical tests on the relationship between long suffering from diabetes mellitus and body mass index obtained a p-value (0.011) so it can be concluded that there is a relationship between duration of suffering from type 2 diabetes mellitus and body mass index (BMI). Furthermore, the results of statistical tests on the relationship between blood sugar levels and body mass index obtained a p-value (0.170) so it can be concluded that there is no relationship between blood sugar levels and body mass index (BMI). It is known that there is a relationship between duration of suffering from type 2 diabetes mellitus and body mass index (BMI) with p value = 0.011 (p 0.05). Key words: Diabetes Melitus, Long Suffering, Blood Sugar Level, Body Mass Index ABSTRAK Hiperglikemia dan IMT abnormal adalah tanda-tanda kemungkinan penyakit metabolik. Diabetes melitus adalah suatu penyakit gangguan metabolik glukosa yang mana tubuh tidak dapat atau kurang baik dalam mengontrol glukosa yang masuk dari makanan sehingga kadar gula darah tinggi. Pada penelitian ini untuk mengetahui hubungan lama menderita diabetes melitus tipe 2 dan kadar gula darah dengan indeks massa tubuh (IMT) pada pasien diabetes melitus tipe 2 di Rumah Sakit Pertamina Bintang Amin Husada Bandar Lampung tahun 2021. Pada penelitian ini menggunakan metode analitik observasional dan dengan pendekatan cross sectional. Pada penelitian ini didapatkan pada hasil uji statistik tentang hubungan lama menderita diabetes melitus dengan indeks massa tubuh diperoleh nilai p-value (0,011) maka dapat disimpulkan bahwa terdapat hubungan antara lama menderita diabetes melitus tipe 2 dengan indeks massa tubuh (IMT). Selanjutnya pada hasil uji statistik tentang hubungan kadar gula darah dengan indeks massa tubuh diperoleh nilai p-value (0,170) maka dapat disimpulkan bahwa tidak terdapat hubungan antara kadar gula darah dengan indeks massa tubuh (IMT). Pada penelitian ini diketahui terdapat hubungan antara lama menderita diabetes melitus tipe 2 dengan indeks massa tubuh (IMT) dengan hasil p value = 0,011 (p0,05). Kata Kunci: Diabetes Melitus, Lama Menderita, Kadar Gula Darah, Indeks Massa Tubuh

Chronic hyperglycemia and insulin resistance in people with type 2 diabetes mellitus cause vascular damage that begins with endothelial dysfunction due to the process of glycosylation and oxidative stress in endothelial cells, where endothelial dysfunction is a condition where the endothelial loses its physiological function such as increasing vasodilation, fibrinolysis, and anti-platelet aggregation. The endothelial layer plays a role in facilitating physical barriers between blood vessel walls and the lumen, by secreting a number of mediators to regulate platelet aggregation, coagulation and fibrinolysis. To determine the relationship between the time blood sugar levels value and the platelet count in type 2 Diabetes mellitus patients at Hospital DR.H. Bob Bazar South Lampung. This research design is correlative analytic with cross sectional method using purposive sampling as many as 201 samples of type 2 Diabetes mellitus patients who match with the inculsion criteria. Data collecting begin in January 2021. The data on this research used secondary data in the form of medical records. After the dat collected, data will evaluated by the Spearman test. The research sample was 201 patients with type 2 diabetes with a minimum value of the time blood sugar levels levels contained in the data 120 mg / dl, the maximum value of the time blood sugar levels levels found in the data was 392 mg / dl and the average time blood sugar level was 227 mg / dl, for the number of platelets. obtained the maximum value of the number of platelets contained in the data is 556,000, the minimum value of the number of platelets in the data is 110,000 and the mean value of platelet count is 266,363. The results of the Spearman correlation showed that the value of p = 0.071 and the value of r = 0.128, because the value of p = 0.071> 0.05 so that it can be stated that Ha is rejected and Ho is accepted or there is no relationship between the two variables studied, with r = 0.128 which means there is no relationship or a weak correlation between time blood sugar levels and platelet counts in type 2 Diabetes mellitus patients at DR. H. Bob Bazar, SKM Hospital South Lampung. There is no relationship between time blood sugar levels and platelet counts in type 2 Diabetes Mellitus patients at DR.H. Bob Bazar, SKM Hospital South Lampung in 2020 with results of p = 0.071 and r = 0.128. Keywords: Diabetes Mellitus, Time Blood Sugar Levels , Platelet ABSTRAK Hiperglikemia kronik dan resistensi insulin pada penderita DM tipe 2 meyebabkan kerusakan vaskuler yang diawali dengan terjadinya disfungsi endotel akibat proses glikosilasi dan stres oksidatif pada sel endotel, dimana disfungsi endotel merupakan kondisi endotel kehilangan fungsi fisiologisnya seperti meningkatkan vasodilatasi, fibrinolysis, dan anti agregasi trombosit. Lapisan endotel berperan untuk memfasilitasi hambatan fisik antara dinding pembuluh darah dengan lumen, dengan cara menysekresikan sejumlah mediator guna mengatur agregasi trombosit, koagulasi dan fibrinolysis. Tujuan penelitian ini untuk mengetahui hubungan antara nilai GDS dengan jumlah trombosit pada pasien DM tipe 2 di Rumah Sakit DR.H. Bob Bazar Lampung Selatan. Jenis Penelitian ini adalah analitik korelatif dengan metode cross sectional menggunakan purposive sampling sebanyak 201 sampel pasien DM tipe 2 yang memenuhi kriteria inkulsi. Pengambilan data dimulai pada bulan Januari 2021. Data yang digunakan yaitu data sekunder berupa rekam medik. Data dievaluasi dengan uji Spearman. Didapatkan sampel penelitian berjumlah 201 pasien DM tipe 2 dengan nilai minimal dari Kadar GDS yang terdapat di data 120 mg/dl , nilai maksimal dari kadar GDS yang terdapat di data 392 mg/dl dan rerata Kadar GDS yaitu 227 mg/dl, untuk jumlah trombosit didapatkan nilai maksimal Jumlah trombosit yang terdapat di data yaitu 556.000 , nilai minimal Jumlah trombosit yang terdapat di data 110.000 dan nilai rerata Jumlah trombosit adalah 266.363. hasil korelasi Spearman didapatkan nilai p=0,071 dan nilai r=0,128, karena nilai p=0,071 > 0,05 sehingga dapat dinyatakan Ha ditolak dan Ho diterima atau tidak terdapat hubungan antara kedua variabel yang diteliti, dengan r=0,128 dapat diartikan tidak terdapat hubungan atau berhubungan lemah antara kadar GDS dengan jumlah trombosit pada pasien DM tipe 2 di Rumah Sakit DR. H. Bob Bazar, SKM Lampung Selatan. Tidak terdapat hubungan antara kadar GDS dengan jumlah trombosit pada pasien DM tipe 2 di Rumah Sakit DR.H. Bob Bazar, SKM Lampung Selatan tahun 2020 dengan hasil p=0,071 dan r=0,128. Kata Kunci: Diabetes Mellitus, Kadar GDS, Jumlah Trombosit

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action, or both (American Diabetes Association, 2017). DM is classified as a non-communicable disease where the sufferer is automatically unable to control the level of sugar in their blood. Globally, an estimated 422 million adults lived with diabetes in 2014, compared to 108 million in 1980. The International Diabetes Federation (IDF) Atlas 2017 reports that the DM epidemic in Indonesia is still showing an increasing trend. Type 2 DM in Indonesia itself is ranked seventh in the world after China, India, the United States, Brazil, Russia and Mexico. WHO predicts an increase in the number of DM sufferers in Indonesia by around 21.3 million in 2030 from 8.4 million in 2000. To determine the relationship between the time blood sugar levels value with urea levels in type 2 Diabetes mellitus patients at Hospital DR.H. Bob Bazar South Lampung in 2020. This type of research is correlative analytic with cross sectional method using purposive sampling as many as 201 samples of type 2 DM patients who meet the inclusion criteria. Data collection began in January 2021. The data used were secondary data in the form of medical records. The data were evaluated using the Spearman test. The research sample was 201 patients with type 2 diabetes with a minimum value of the GDS levels contained in the data 120 mg / dl, the maximum value of the GDS levels found in the data was 392 mg / dl and the average GDS level was 227 mg / dl, for urum levels. The highest urea level values found in the data were 117, the lowest urea levels were found in data 13 and the mean urea levels were 44.32. The results of the Spearman correlation obtained the value of p = 0.000 and the value of r = 0.695, because the value of p = 0.000

THE RELATIONSHIP OF LUPUS ERYTHEMATOSUS (SLE) SYSTEMIC DISEASE ACTIVITIES BASED ON MEX SLEDAI SCORES AND QUALITY OF LIFE IN ODAPUS COMMUNITIES BANDAR LAMPUNG Background: Systemic Lupus Erythematosus (SLE) is an autoimmune rheumatic disease characterized by widespread inflammation that affects every organ or system in the body. The clinical manifestations of LES vary depending on the organs involved, which can involve many organs in the human body with a complex and varied clinical course.Research objectives: This study aims to determine the relationship between disease activity systemic lupus erythematosus (sle)based on the MEX SLEDAI score with the quality of life in the Odapus community, Bandar Lampung City in 2020.Research method: The type of research used in this study was analytic with design total sampling. The sample used in this study were all Systemic Lupus Erythematosus (SLE) patients in the Odapus community, Bandar Lampung City in 2020 who met the inclusion criteria as many as 40 people. Data analysis used correlation test Spearman's.Results: The results of the study were found in SLE patients based on the MEX SLEDAI score, namely 17 people (42.5%) of moderate activity and 23 people (57.2%) of poor quality of life also obtained p-value = 0.002 and correlation = -0.474 .Conclusion: There is a relationship between disease activity systemic lupus erythematosus (SLE)based on the MEX SLEDAI score with the quality of life in the Odapus community, Bandar Lampung city in 2020. Keywords: SLE disease activity, MEX SLEDAI score, Quality of life INTISARI: HUBUNGAN AKTIVITAS PENYAKIT SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) BERDASARKAN SKOR MEX SLEDAI DENGAN KUALITAS HIDUP DI KOMUNITAS ODAPUS KOTA BANDAR LAMPUNG Latar Belakang: Systemic Lupus Erythematosus (SLE) adalah penyakit reumatik autoimun yang ditandai adanya inflamasi tersebar luas, yang mempengaruhi setiap organ atau sistem dalam tubuh. Manifestasi klinik dari LES beragam tergantung organ yang terlibat, dimana dapat melibatkan banyak organ dalam tubuh manusia dengan perjalanan klinis yang komplek dan bervariasi.Tujuan penelitian: Penelitian ini ditujukan untuk mengetahui hubungan aktivitas penyakit systemic lupus erythematosus (SLE) berdasarkan skor MEX SLEDAI dengan kualitas hidup di komunitas Odapus Kota Bandar Lampung Tahun 2020.Metode penelitian: Jenis penelitian yang digunakan dalam penelitian ini adalah analitik dengan desain Total Sampling. Sampel yang digunakan pada penelitian ini adalah seluruh pasien Systemic Lupus Erythematosus (SLE) di komunitas Odapus Kota Bandar Lampung Tahun 2020 yang memenuhi kriteria inklusi sebanyak 40 orang. Analisa data menggunakan uji korelasi Spearman’s.Hasil Penelitian: Didapatkan hasil penelitian pada pasien SLE berdasarkan skor MEX SLEDAI yaitu pada aktivitas sedang sebanyak 17 orang (42.5%) dan kualitas hidup yang buruk sebanyak 23 orang (57.2%), juga didapatkan nilai p-value =0.002 dan korelasi =-0.474.Kesimpulan: Ada hubungan aktivitas penyakit systemic lupus erythematosus (SLE) berdasarkan skor MEX SLEDAI dengan kualitas hidup di komunitas odapus kota Bandar Lampung Tahun 2020. Kata kunci: Aktivitas penyakit SLE, Skor MEX SLEDAI, Kualitas hidup

Systemic Lupus Erythematosus (SLE) is a participatory systemic autoimmune condition involving many organ systems in the body and high production of autoantibodies. Objective to see the relationship between the degree of disease activity and fibromyalgia in systemic lupus eriythematosus patients in the ODAPUS Lampung community in 2020. Cross-sectional analytic. Sampling was done using total sampling. Respondents of this study were all Lupus patients in the ODAPUS Community in Lampung, as many as 40 people. Showed that from 40 patient respondents, 5 respondents (12.5%) had the degree of mild disease activity, 35 respondents (87.5%) had no diagnosis. fibromyalgia 14 Respondents (35.0%), diagnosed with fibromyalgia 26 respondents (65.0%) Chi Square analysis results obtained p-value = 0.000 (p ≤ 0.05), which is a relationship between the degree of disease activity and fibromyalgia in systemic lupus patients eriythematosus in the ODAPUS community in Lampung. The existence of a relationship between the degree of disease activity and fibromyalgia in systemic lupus eriythematosus (SLE) patients in the Lampung ODAPUS community in 2020 with (p

Hemorrhoids, or people who are better known as hemorrhoids, are a common disease and have been around since time immemorial. The incidence of hemorrhoids tends to increase where the peak age is 45-65 years. Hemorrhoids can affect both men and women (Sunarto, 2016). This study aims to determine the factors associated with external hemorrhoids and internal hemorrhoids in PertaminaBintang Amin Hospital, Bandar Lampung in 2017-2019. The type of research used is quantitative research with observational analytic methods using a cross-sectional design. The sample in this study is all medical record data in 2017-2019 at Bintang Amin Hospital, Bandar Lampung, as many as 65 samples with total sampling technique. Data obtained through medical records. The data analysis technique to test the hypothesis was the chi-square statistical test. Results of analysis of factors associated with external hemorrhoids and internal hemorrhoids in hemorrhoid patients at Pertamina Bintang Amin Hospital 2017-2019. The age factor from the statistical results shows that there is a p-value = 0.101 which means it is greater than (p-value

Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks the immune system. Patients with SLE who are immunologically and genetically compromised are predisposed to infection. Currently the world, including Indonesia, is being hit by the COVID-19 pandemic, which is a respiratory tract infection caused by the corona virus. Because of the easy and fast way of transmission, the community is no exception for SLE sufferers who are more susceptible to infection for fear of contracting this virus, this can cause psychological conditions that can be experienced, namely anxiety. To determine the analysis of anxiety levels in patients with Systemic Lupus Erythematosus Community ODAPUS Lampung during the COVID-19 Pandemic. This type of research is descriptive with a cross sectional approach using the Zung Self-rating Anxiety Scale online questionnaire. The sample of this study was all patients diagnosed with Systemic Lupus Erythematosus in the ODAPUS Lampung community as many as 40 people. Data analysis used univariate analysis by using tables in presenting the data. The results of the study of 40 patients showed that the characteristics of SLE patients based on age were mostly adults (65%), the most gender were women (97.5%), the last education was college. (60%), most of the jobs are at university level. IRT (42.5%), on the level of anxiety obtained normal anxiety (50%) and mild anxiety (50%). It is known that the analysis of the level of anxiety in patients with Systemic Lupus Erythematosus Community ODAPUS Lampung during the COVID-19 pandemic showed that there were 20 patients with normal anxiety levels, 20 patients with mild anxiety, and no patients with mild anxiety. moderate or severe anxiety levels of a total of 40 patients. Keywords: SLE, COVID-19, Anxiety Level ABSTRAK Systemic lupus erythematosus (SLE) adalah suatu penyakit autoimun, yang menyerang kekebalan tubuh. Pasien dengan SLE yang terganggu imunologi serta genetik menjadi predisposisi terjadinya infeksi. Saat ini, dunia termasuk Indonesia sedang dilanda pandemi COVID-19 yang merupakan infeksi saluran pernapasan oleh corona virus. Karena cara penularannya yang mudah dan cepat membuat masyarakat tidak terkecuali pasien SLE yang lebih rentan terkena infeksi takut tertular oleh virus ini, hal ini dapat menyebabkan satu keadaan psikologi yang bisa dialami yaitu rasa cemas. Tujuan penelitian ini untuk mengetahui Analisis Tingkat Kecemasan pada pasien Systemic Lupus Erythematosus di Komunitas ODAPUS Lampung pada masa Pandemi COVID-19. Jenis penelitian ini adalah deskriptif dengan pendekatan Cross-sectional menggunakan kuesioner Zung Self-rating Anxiety Scale secara online. Sampel penelitian ini adalah seluruh pasien yang terdiagnosa Systemic Lupus Erythematosus di komunitas ODAPUS Lampung sebanyak 40 orang. Analisis data menggunakan analisis univariat dengan menggunakan tabel dalam penyajian data. Hasil penelitian dari 40 pasien tersebut didapatkan karakteristik pasien SLE berdasarkan usia terbanyak yaitu pada dewasa (65%), jenis kelamin terbanyak yaitu perempuan (97,5%), pendidikan terakhir terbanyak pada tingkat perguruan tinggi (60%), pekerjaan terbanyak pada IRT (42,5%), pada tingkat kecemasan didapatkan normal (50%) dan kecemasan ringan (50%). Diketahui analisis tingkat kecemasan pada pasien Systemic Lupus Erythematosus di Komunitas ODAPUS Lampung pada masa pandemi COVID-19 yaitu didapatkan tingkat kecemasan normal terdapat 20 pasien, kecemasan ringan 20 pasien dan tidak ditemukan pasien pada tingkat kecemasan sedang maupun berat dari total keseluruhan 40 pasien. Kata Kunci : SLE, COVID-19, Tingkat Kecemasan

DESCRIPTION OF THE QUALITY OF VISION FUNCTION IN SYSTEMIC LUPUS ERYTHEMA PATIENTS BASED ON THE NEI VFQ-25 QUESTIONNAIRE IN THE ODAPUS COMMUNITY OF LAMPUNGBackground: Systemic Lupus Erythematosus /Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease that has characteristic manifestations or symptoms and varied clinical behavior. Eye involvement can be found in about one-third of cases of SLE, and sometimes occurs early in the disease. To assess and measure the quality of vision function in patients with Systemic Lupus Erythematosus, a measuring instrument that can be used is the National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25) questionnaire. Objective: To describe the quality of vision function in patients with systemic lupus erythematosus based on the NEI VFQ-25 questionnaire in the ODAPUS community in Lampung 2020. Research Methods: This research is a descriptive survey with an approach cross-sectional using primary data in the form of a questionnaire. The sample of this study was all 40 patients who joined the ODAPUS community in Lampung. Data analysis used univariate analysis using tables and graphs in data presentation. Results: The results of the study were 40 patients who met the criteria for inclusion in the study. Of the 40 patients, the patient characteristics were obtained based on the quality of vision function, namely 26-45 years (65.0%), female (97.5%), tertiary education (65.0 %), IRT (42.5%), quality of vision function is not good (90 , 0%), low-dose corticosteroids (85.0%). Conclusion: Given picture quality visual functions of patients with systemic lupus erythematosus-based questionnaire NEI VFQ-25 in the community of Lampung odapus 2020 is not good. Keywords: Quality Vision Function, SLE INTISARI: GAMBARAN KUALITAS FUNGSI PENGLIHATAN PASIEN SYSTEMIC LUPUS ERYTHEMATOSUS BERDASARKAN KUESIONER NEI VFQ-25 DI KOMUNITAS ODAPUS LAMPUNG Latar Belakang: Lupus Eritematosus Sistemic/Systemic Lupus Erythematosus (SLE) adalah suatu penyakit autoimun multisistem yang memiliki manifestasi atau gejala khas dan perilaku klinis yang sangat bervariasi. Keterlibatan mata dapat ditemukan pada kurang lebih satu per tiga kasus SLE, dan kadang terjadi pada awal penyakit. Untuk menilai dan mengukur kualitas fungsi penglihatan pada pasien Systemic Lupus Erythematosus, alat ukur yang dapat digunakan yaitu dengan kuesioner National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25).Tujuan: Untuk mengetahui gambaran kualitas fungsi penglihatan pasien systemic lupus erythematosus berdasarkan kuesioner NEI VFQ-25 di komunitas ODAPUS Lampung 2020.Metode Penelitian: Jenis penelitian ini adalah survei deskriptif dengan pendekatan Cross- sectional menggunakan data primer berupa kuesioner. Sampel penelitian ini adalah seluruh pasien yang bergabung di komunitas ODAPUS Lampung sebanyak 40 orang. Analisis data menggunakan analisis univariat dengan menggunakan tabel dan grafik dalam penyajian data.Hasil: Hasil penelitian terdapat 40 pasien yang memenuhi kriteria untuk dimasukkan dalam penelitian. Dari 40 pasien tersebut didapatkan karakteristik pasien berdasarkan kualitas fungsi penglihatan yaitu terbanyak pada usia 26-45 tahun (65,0%), jenis kelamin perempuan (97,5%), pendidikan perguruan tinggi (65,0%), pekerjaan IRT (42,5%), kualitas fungsi penglihatan tidak baik (90,0%), dan penggunaan kortikosteroid dosis rendah (85,0%). Kesimpulan: Gambaran kualitas fungsi penglihatan pasien systemic lupus erythematosus berdasarkan kuesioner NEI VFQ-25 di komunitas ODAPUS Lampung 2020 yaitu tidak baik. Kata Kunci : Kualitas Fungsi Penglihatan, SLE

RELATIONSHIP OF SLE (SYSTEMIC LUPUS ERYTHEMATOSUS) ACTIVITIES BASED ON MEX-SLEDAI SCORING ON DEPRESSION IN ODAPUS COMMUNITIES BANDAR LAMPUNG Background: Depression is a clinical manifestation that can occur in patients with SLE and it is suspected that the level of SLE disease activity can affect these events (Nery, et al. 2007). Ironically, this section is a part that is often overlooked by many people, including the health sector. In fact, by understanding this point of view, cross-scientific collaborative treatment such as the Internal and Psychiatry Fields can be done to improve the treatment and quality of life of patients.Objective: To determine the relationship between SLE (Systemic lupus Erythematosus) disease activity based on MEX-SLEDAI Scoring against depression in the Odapus Community, Bandar Lampung City 2020.Methodology: The type of research used in this study is correlative analytic with cross-sectional design. The sample used in this study were patients with SLE (Systemic lupus Erythematosus) based on MEX-SLEDAI Scoring for depression in the Odapus Community, Bandar Lampung City 2020. Data analysis used the Spearman test.Results: In the activity variable SLE and depression, the P value = 0.001 (P

Rheumatoid Arthritis or RA disease is a chronic inflammatory and systemic disease associated with broad synovitis resulting in erosion of the articular cartilage and marginal bone causing joint damage. RA is an autoimmune disease with the discovery of an autoantibody, namely rheumatoid factor. The relevant antibody is anti-citrullinated protein (ACPA) antibody. Citullination on the introduction of several proteins such as fibrin, vimentin, fibronectin, collagen type II, which is expressed in the synovial membrane during inflammation by ACPA. In a recent study increased HDAC activity in the synovial tissue of RA patients has increased. Histone deacetylase or abbreviated as HDAC is an enzyme that is important in regulating gene transcription by altering the acetylation of histone proteins which results in an important regulation of repression in the implementation of inflammation. HDAC enzyme inhibitor (HDACi) is an HDAC enzyme inhibitor that can provide benefits for the treatment of various diseases including malignancy and inflammation. In inflammatory disease HDACi overcomes inflammatory cytokines such as TNF-α, IL-6 and IL-1β. One of the HDAC classes is HDAC1 which is highly expressed in the synovial fibroblasts of RA patients. HDACi can burden swollen joints, reduce mononuclear cell infiltration, request pannus orders, inhibit bone and cartilage damage.

Chronic Kidney Disease (CKD) merupakan masalah yang sangat serius, dimana terjadi kerusakan ginjal yang terjadi selama lebih dari 3 bulan, terapi yang biasa dilakukan untuk pasien ckd adalah dengan melakukan hemodialisa dimana digunakan untuk mengambil zat – zat nitrogen yang bersifat toksik dari dalam darah, tindakan tersebut mempunyai efek samping pada kondisi fisik serta psikologis penderita CKD. Trombosit memiliki peran penting yaitu melindungi integritas endotel pembuluh darah dalam proses hemostasis apabila terjadi kerusakan pada dinding pembuluh darah. Hasil pemeriksaan hitung trombosit dipengaruhi oleh suhu dan waktu sejak pengumpulan spesimen. Hasil pemeriksaan hitung trombosit dipengaruhi oleh suhu dan waktu sejak pengumpulan spesimen. Pada pemeriksaan laboratorium bisa terjadi kelainan pada trombosit yaitu trombositopenia dan trombositosis. Penelitian ini bersifat analitik retrospektif dengan desain cross sectional. Teknik pengambilan sampel secara total sampling, dengan sampel yang dipakai sebanyak 76. Berdasarkan lama menjalankan perawatan HD terhadap kadar trombosit diperoleh (p-value = 0,294), sedangkan lama waktu pelaksanaan HD terhadap kadar trombosit (p-value 0,014). Tidak terdapat hubungan yang signifikan lama menjalankan perawatan HD dengan kadar trombosit pada pasien CKD, dan terdapat hubungan yang signifikan lama proses HD dengan kadar trombosit pada pasien CKD di RSPBA Bandar Lampung Tahun 2019 – 2020.

Tekanan intraokular pada ablasio retina umumnya mengalami peningkatan/ penurunan, sehingga dibutuhkan operasi ablasio retina untuk mengembalikan tekanan intraokular menjadi normal. Ablasio retina (retinal detachment) merupakan keadaan terpisahnya bagian sensoris retina (fotoreseptor dan lapisan jaringan dalam) dari retinal pigment epithelium (RPE). Untuk mengetahui perubahan antara tekanan intraokular pre dan pasca operasi ablasio retina di RSPBA Bandar Lampung tahun 2020. Penelitian ini menggunakan metode komparatif dengan pendekatan cross sectional. Sampel dalam penelitian ini sebanyak 53 orang. Instrumen yang digunakan adalah data rekam medik. Hasil analisis statistik menggunakan uji Paired Sample T-Test menunjukkan p-value = 0,271 lebih besar dari 0,05 (α>0,05) dengan selisih rerata 1,24 yang berarti menunjukan tidak adanya perbedaan yang bermakna pada jumlah Tekanan Intraokular (TIO) sebelum dan sesudah pars plana vitrektomi, namun jika dilihat dari selisih reratanya ada perubahan antara sebelum dan sesudah pars plana vitrektomi. Tidak terdapat perbedaan bermakna antara Tekanan Intraokular sebelum dan sesudah pars plana vitrektomi.

Merokok merupakan salah satu kegiatan yang masih dilakukan individu dalam segala usia mulai dari anak-anak hingga dewasa dan tidak menutup kemungkinan untuk mereka yang sebelumnya sudah merokok, kemudian merokok kembali, ataupun bagi mereka yang sebelumnya belum pernah mencoba merokok pun menjadi tertarik untuk mencobanya. Perlahan seperti air, mereka selalu memiliki alasan untuk merokok. Prevalensi perokok aktif di Indonesia meningkat sangat cepat. Apabila pemerintah tidak sigap dengan kebijakan yang lebih efektif, diperkirakan pada tahun 2025 jumlah perokok di Indonesia akan bertambah sebanyak 90 juta orang