31 results on '"Ringwald, Kai G."'
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2. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.
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Schijven, Dick, Postema, Merel C, Fukunaga, Masaki, Matsumoto, Junya, Miura, Kenichiro, de Zwarte, Sonja MC, van Haren, Neeltje EM, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa, Ortiz-García de la Foz, Víctor, Tordesillas-Gutierrez, Diana, Vázquez-Bourgon, Javier, Crespo-Facorro, Benedicto, Alnæs, Dag, Dahl, Andreas, Westlye, Lars T, Agartz, Ingrid, Andreassen, Ole A, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E, Schall, Ulrich, Scott, Rodney J, Carr, Vaughan J, Green, Melissa J, Henskens, Frans A, Loughland, Carmel M, Pantelis, Christos, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo TJ, Nenadić, Igor, Krämer, Bernd, Gruber, Oliver, Satterthwaite, Theodore D, Bustillo, Juan, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D, Ford, Judith M, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan, Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond, Sarró, Salvador, Pomarol-Clotet, Edith, Ciullo, Valentina, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N, Sim, Kang, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André, Borgwardt, Stefan, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, and Antonucci, Linda A
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Brain ,Cerebral Cortex ,Humans ,Magnetic Resonance Imaging ,Case-Control Studies ,Schizophrenia ,Female ,Male ,Functional Laterality ,asymmetry ,brain imaging ,cortical ,subcortical ,Clinical Research ,Mental Health ,Neurosciences ,Brain Disorders ,Mental health - Abstract
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
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- 2023
3. Brain Structural Network Connectivity of Formal Thought Disorder Dimensions in Affective and Psychotic Disorders
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Stein, Frederike, Gruber, Marius, Mauritz, Marco, Brosch, Katharina, Pfarr, Julia-Katharina, Ringwald, Kai G., Thomas-Odenthal, Florian, Wroblewski, Adrian, Evermann, Ulrika, Steinsträter, Olaf, Grumbach, Pascal, Thiel, Katharina, Winter, Alexandra, Bonnekoh, Linda M., Flinkenflügel, Kira, Goltermann, Janik, Meinert, Susanne, Grotegerd, Dominik, Bauer, Jochen, Opel, Nils, Hahn, Tim, Leehr, Elisabeth J., Jansen, Andreas, de Lange, Siemon C., van den Heuvel, Martijn P., Nenadić, Igor, Krug, Axel, Dannlowski, Udo, Repple, Jonathan, and Kircher, Tilo
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- 2024
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4. Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
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McWhinney, Sean R, Abé, Christoph, Alda, Martin, Benedetti, Francesco, Bøen, Erlend, del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J, Cannon, Dara M, Dannlowski, Udo, Díaz-Zuluaga, Ana M, Elvsåshagen, Torbjørn, Eyler, Lisa T, Fullerton, Janice M, Goikolea, Jose M, Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus CM, Hahn, Tim, Howells, Fleur M, Ingvar, Martin, Kircher, Tilo TJ, Krug, Axel, Kuplicki, Rayus T, Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F, Martyn, Fiona M, Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa MT, Mitchell, Philip B, Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A, Overs, Bronwyn J, Pfarr, Julia-Katharina, Pineda-Zapata, Julian A, Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G, Roberts, Gloria, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R, Sim, Kang, Stein, Dan J, Stein, Frederike, Temmingh, Henk S, Thiel, Katharina, van Haren, Neeltje EM, Gestel, Holly Van, Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N, Ching, Christopher RK, Andreassen, Ole, Thompson, Paul M, and Hajek, Tomas
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Biomedical Imaging ,Nutrition ,Brain Disorders ,Obesity ,Neurosciences ,Clinical Research ,Prevention ,Mental health ,Amygdala ,Bipolar Disorder ,Body Mass Index ,Brain ,Humans ,Magnetic Resonance Imaging ,ENIGMA Bipolar Disorders Working Group ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
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- 2021
5. Data-driven multivariate identification of gyrification patterns in a transdiagnostic patient cohort: A cluster analysis approach
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Pfarr, Julia-Katharina, Meller, Tina, Brosch, Katharina, Stein, Frederike, Thomas-Odenthal, Florian, Evermann, Ulrika, Wroblewski, Adrian, Ringwald, Kai G., Hahn, Tim, Meinert, Susanne, Winter, Alexandra, Thiel, Katharina, Flinkenflügel, Kira, Jansen, Andreas, Krug, Axel, Dannlowski, Udo, Kircher, Tilo, Gaser, Christian, and Nenadić, Igor
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- 2023
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6. Associations of gestational age with gyrification and neurocognition in healthy adults
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Schmitt, Simon, Ringwald, Kai G., Meller, Tina, Stein, Frederike, Brosch, Katharina, Pfarr, Julia-Katharina, Hahn, Tim, Lemke, Hannah, Meinert, Susanne, Repple, Jonathan, Thiel, Katharina, Waltemate, Lena, Winter, Alexandra, Grotegerd, Dominik, Dempfle, Astrid, Jansen, Andreas, Krug, Axel, Dannlowski, Udo, Nenadić, Igor, and Kircher, Tilo
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- 2023
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7. Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses
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Kalman, Janos L., Yoshida, Tomoya, Andlauer, Till F. M., Schulte, Eva C., Adorjan, Kristina, Alda, Martin, Ardau, Raffaela, Aubry, Jean-Michel, Brosch, Katharina, Budde, Monika, Chillotti, Caterina, Czerski, Piotr M., DePaulo, Raymond J., Forstner, Andreas, Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Grotegerd, Dominik, Hahn, Tim, Heilbronner, Maria, Hasler, Roland, Heilbronner, Urs, Heilmann-Heimbach, Stefanie, Kapelski, Pawel, Kato, Tadafumi, Kohshour, Mojtaba Oraki, Meinert, Susanne, Meller, Tina, Nenadić, Igor, Nöthen, Markus M., Novak, Tomas, Opel, Nils, Pawlak, Joanna, Pfarr, Julia-Katharina, Potash, James B., Reich-Erkelenz, Daniela, Repple, Jonathan, Richard-Lepouriel, Hélène, Rietschel, Marcella, Ringwald, Kai G., Rouleau, Guy, Schaupp, Sabrina, Senner, Fanny, Severino, Giovanni, Squassina, Alessio, Stein, Frederike, Stopkova, Pavla, Streit, Fabian, Thiel, Katharina, Thomas-Odenthal, Florian, Turecki, Gustavo, Twarowska-Hauser, Joanna, Winter, Alexandra, Zandi, Peter P., Kelsoe, John R., Falkai, Peter, Dannlowski, Udo, Kircher, Tilo, Schulze, Thomas G., and Papiol, Sergi
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- 2022
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8. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
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van Velzen, Laura S., Dauvermann, Maria R., Colic, Lejla, Villa, Luca M., Savage, Hannah S., Toenders, Yara J., Zhu, Alyssa H., Bright, Joanna K., Campos, Adrián I., Salminen, Lauren E., Ambrogi, Sonia, Ayesa-Arriola, Rosa, Banaj, Nerisa, Başgöze, Zeynep, Bauer, Jochen, Blair, Karina, Blair, Robert James, Brosch, Katharina, Cheng, Yuqi, Colle, Romain, Connolly, Colm G., Corruble, Emmanuelle, Couvy-Duchesne, Baptiste, Crespo-Facorro, Benedicto, Cullen, Kathryn R., Dannlowski, Udo, Davey, Christopher G., Dohm, Katharina, Fullerton, Janice M., Gonul, Ali Saffet, Gotlib, Ian H., Grotegerd, Dominik, Hahn, Tim, Harrison, Ben J., He, Mengxin, Hickie, Ian B., Ho, Tiffany C., Iorfino, Frank, Jansen, Andreas, Jollant, Fabrice, Kircher, Tilo, Klimes-Dougan, Bonnie, Klug, Melissa, Leehr, Elisabeth J., Lippard, Elizabeth T. C., McLaughlin, Katie A., Meinert, Susanne, Miller, Adam Bryant, Mitchell, Philip B., Mwangi, Benson, Nenadić, Igor, Ojha, Amar, Overs, Bronwyn J., Pfarr, Julia-Katharina, Piras, Fabrizio, Ringwald, Kai G., Roberts, Gloria, Romer, Georg, Sanches, Marsal, Sheridan, Margaret A., Soares, Jair C., Spalletta, Gianfranco, Stein, Frederike, Teresi, Giana I., Tordesillas-Gutiérrez, Diana, Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J., Vermeiren, Robert R. J. M., Winter, Alexandra, Wu, Mon-Ju, Yang, Tony T., Thompson, Paul M., Rentería, Miguel E., Jahanshad, Neda, Blumberg, Hilary P., van Harmelen, Anne-Laura, and Schmaal, Lianne
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- 2022
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9. Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders
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Brosch, Katharina, Stein, Frederike, Schmitt, Simon, Pfarr, Julia-Katharina, Ringwald, Kai G., Thomas-Odenthal, Florian, Meller, Tina, Steinsträter, Olaf, Waltemate, Lena, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Breuer, Fabian, Thiel, Katharina, Grotegerd, Dominik, Hahn, Tim, Jansen, Andreas, Dannlowski, Udo, Krug, Axel, Nenadić, Igor, and Kircher, Tilo
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- 2022
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10. Brain structural correlates of recurrence following the first episode in patients with major depressive disorder
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Lemke, Hannah, Klute, Hannah, Skupski, Jennifer, Thiel, Katharina, Waltemate, Lena, Winter, Alexandra, Breuer, Fabian, Meinert, Susanne, Klug, Melissa, Enneking, Verena, Winter, Nils R., Grotegerd, Dominik, Leehr, Elisabeth J., Repple, Jonathan, Dohm, Katharina, Opel, Nils, Stein, Frederike, Meller, Tina, Brosch, Katharina, Ringwald, Kai G., Pfarr, Julia-Katharina, Thomas-Odenthal, Florian, Hahn, Tim, Krug, Axel, Jansen, Andreas, Heindel, Walter, Nenadić, Igor, Kircher, Tilo, and Dannlowski, Udo
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- 2022
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11. Brain structural network connectivity of formal thought disorder dimensions in affective and psychotic disorders
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Stein, Frederike, primary, Gruber, Marius, additional, Mauritz, Marco, additional, Brosch, Katharina, additional, Pfarr, Julia-Katharina, additional, Ringwald, Kai G., additional, Thomas-Odenthal, Florian, additional, Wroblewski, Adrian, additional, Evermann, Ulrika, additional, Steinsträter, Olaf, additional, Grumbach, Pascal, additional, Thiel, Katharina, additional, Winter, Alexandra, additional, Bonnekoh, Linda M., additional, Flinkenflügel, Kira, additional, Goltermann, Janik, additional, Meinert, Susanne, additional, Grotegerd, Dominik, additional, Bauer, Jochen, additional, Opel, Nils, additional, Hahn, Tim, additional, Leehr, Elisabeth J., additional, Jansen, Andreas, additional, de Lange, Siemon C., additional, van den Heuvel, Martijn, additional, Nenadić, Igor, additional, Krug, Axel, additional, Dannlowski, Udo, additional, Repple, Jonathan, additional, and Kircher, Tilo, additional
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- 2023
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12. Shared and Specific Patterns of Structural Brain Connectivity Across Affective and Psychotic Disorders
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Repple, Jonathan, Gruber, Marius, Mauritz, Marco, de Lange, Siemon C., Winter, Nils Ralf, Opel, Nils, Goltermann, Janik, Meinert, Susanne, Grotegerd, Dominik, Leehr, Elisabeth J., Enneking, Verena, Borgers, Tiana, Klug, Melissa, Lemke, Hannah, Waltemate, Lena, Thiel, Katharina, Winter, Alexandra, Breuer, Fabian, Grumbach, Pascal, Hofmann, Hannes, Stein, Frederike, Brosch, Katharina, Ringwald, Kai G., Pfarr, Julia, Thomas-Odenthal, Florian, Meller, Tina, Jansen, Andreas, Nenadic, Igor, Redlich, Ronny, Bauer, Jochen, Kircher, Tilo, Hahn, Tim, van den Heuvel, Martijn, Dannlowski, Udo, Repple, Jonathan, Gruber, Marius, Mauritz, Marco, de Lange, Siemon C., Winter, Nils Ralf, Opel, Nils, Goltermann, Janik, Meinert, Susanne, Grotegerd, Dominik, Leehr, Elisabeth J., Enneking, Verena, Borgers, Tiana, Klug, Melissa, Lemke, Hannah, Waltemate, Lena, Thiel, Katharina, Winter, Alexandra, Breuer, Fabian, Grumbach, Pascal, Hofmann, Hannes, Stein, Frederike, Brosch, Katharina, Ringwald, Kai G., Pfarr, Julia, Thomas-Odenthal, Florian, Meller, Tina, Jansen, Andreas, Nenadic, Igor, Redlich, Ronny, Bauer, Jochen, Kircher, Tilo, Hahn, Tim, van den Heuvel, Martijn, and Dannlowski, Udo
- Abstract
BACKGROUND: Altered brain structural connectivity has been implicated in the pathophysiology of psychiatric disorders including schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). However, it is unknown which part of these connectivity abnormalities are disorder specific and which are shared across the spectrum of psychotic and affective disorders. We investigated common and distinct brain connectivity alterations in a large sample (N = 1743) of patients with SZ, BD, or MDD and healthy control (HC) subjects.METHODS: This study examined diffusion-weighted imaging-based structural connectome topology in 720 patients with MDD, 112 patients with BD, 69 patients with SZ, and 842 HC subjects (mean age of all subjects: 35.7 years). Graph theory-based network analysis was used to investigate connectome organization. Machine learning algorithms were trained to classify groups based on their structural connectivity matrices.RESULTS: Groups differed significantly in the network metrics global efficiency, clustering, present edges, and global connectivity strength with a converging pattern of alterations between diagnoses (e.g., efficiency: HC > MDD > BD > SZ, false discovery rate-corrected p = .028). Subnetwork analysis revealed a common core of edges that were affected across all 3 disorders, but also revealed differences between disorders. Machine learning algorithms could not discriminate between disorders but could discriminate each diagnosis from HC. Furthermore, dysconnectivity patterns were found most pronounced in patients with an early disease onset irrespective of diagnosis.CONCLUSIONS: We found shared and specific signatures of structural white matter dysconnectivity in SZ, BD, and MDD, leading to commonly reduced network efficiency. These results showed a compromised brain communication across a spectrum of major psychiatric disorders.
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- 2023
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13. Mega-analysis of association between obesity and cortical morphology in bipolar disorders:ENIGMA study in 2832 participants
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Mcwhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Boen, Erlend, Del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Diaz-Zuluaga, Ana M., Dietze, Lorielle M.F., Elvsåshagen, Torbjorn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C.M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Jahanshad, Neda, Kircher, Tilo T.J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, Mcdonald, Colm, Mcphilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M.T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Ross, Alex, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, Thomopoulos, Sophia I., Van Haren, Neeltje E.M., Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R.K., Andreassen, Ole A., Thompson, Paul M., Hajek, Tomas, Mcwhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Boen, Erlend, Del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Diaz-Zuluaga, Ana M., Dietze, Lorielle M.F., Elvsåshagen, Torbjorn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C.M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Jahanshad, Neda, Kircher, Tilo T.J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, Mcdonald, Colm, Mcphilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M.T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Ross, Alex, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, Thomopoulos, Sophia I., Van Haren, Neeltje E.M., Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R.K., Andreassen, Ole A., Thompson, Paul M., and Hajek, Tomas
- Abstract
Background: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact. Methods: We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations. Results: BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI. Conclusions: We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.
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- 2023
14. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
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Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, Francks, Clyde; https://orcid.org/0000-0002-9098-890X, Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, and Francks, Clyde; https://orcid.org/0000-0002-9098-890X
- Abstract
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
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- 2023
15. Temporal stability and state-dependence of retrospective self-reports of childhood maltreatment in healthy and depressed adults.
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Goltermann, Janik, primary, Meinert, Susanne, additional, Hülsmann, Carina, additional, Dohm, Katharina, additional, Grotegerd, Dominik, additional, Redlich, Ronny, additional, Waltemate, Lena, additional, Lemke, Hannah, additional, Thiel, Katharina, additional, Mehler, David M. A., additional, Enneking, Verena, additional, Borgers, Tiana, additional, Repple, Jonathan, additional, Gruber, Marius, additional, Winter, Nils, additional, Hahn, Tim, additional, Brosch, Katharina, additional, Meller, Tina, additional, Ringwald, Kai G., additional, Schmitt, Simon, additional, Stein, Frederike, additional, Pfarr, Julia-Katharina, additional, Krug, Axel, additional, Nenadić, Igor, additional, Kircher, Tilo, additional, Opel, Nils, additional, and Dannlowski, Udo, additional
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- 2023
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16. Shared and Specific Patterns of Structural Brain Connectivity Across Affective and Psychotic Disorders
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Repple, Jonathan, primary, Gruber, Marius, additional, Mauritz, Marco, additional, de Lange, Siemon C., additional, Winter, Nils Ralf, additional, Opel, Nils, additional, Goltermann, Janik, additional, Meinert, Susanne, additional, Grotegerd, Dominik, additional, Leehr, Elisabeth J., additional, Enneking, Verena, additional, Borgers, Tiana, additional, Klug, Melissa, additional, Lemke, Hannah, additional, Waltemate, Lena, additional, Thiel, Katharina, additional, Winter, Alexandra, additional, Breuer, Fabian, additional, Grumbach, Pascal, additional, Hofmann, Hannes, additional, Stein, Frederike, additional, Brosch, Katharina, additional, Ringwald, Kai G., additional, Pfarr, Julia, additional, Thomas-Odenthal, Florian, additional, Meller, Tina, additional, Jansen, Andreas, additional, Nenadic, Igor, additional, Redlich, Ronny, additional, Bauer, Jochen, additional, Kircher, Tilo, additional, Hahn, Tim, additional, van den Heuvel, Martijn, additional, and Dannlowski, Udo, additional
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- 2023
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17. Interaction of recent stressful life events and childhood abuse on orbitofrontal grey matter volume in adults with depression
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Ringwald, Kai G., primary, Pfarr, Julia-Katharina, additional, Schmitt, Simon, additional, Stein, Frederike, additional, Brosch, Katharina, additional, Meller, Tina, additional, Andrae, Jonathan, additional, Zech, Ronja, additional, Steinsträter, Olaf, additional, Meinert, Susanne, additional, Waltemate, Lena, additional, Lemke, Hannah, additional, Thiel, Katharina, additional, Winter, Alexandra, additional, Opel, Nils, additional, Goltermann, Janik, additional, Jansen, Andreas, additional, Dannlowski, Udo, additional, Krug, Axel, additional, Nenadić, Igor, additional, and Kircher, Tilo, additional
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- 2022
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18. Associations of gestational age with gyrification and neurocognition in healthy adults
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Schmitt, Simon, primary, Ringwald, Kai G., additional, Meller, Tina, additional, Stein, Frederike, additional, Brosch, Katharina, additional, Pfarr, Julia-Katharina, additional, Hahn, Tim, additional, Lemke, Hannah, additional, Meinert, Susanne, additional, Repple, Jonathan, additional, Thiel, Katharina, additional, Waltemate, Lena, additional, Winter, Alexandra, additional, Grotegerd, Dominik, additional, Dempfle, Astrid, additional, Jansen, Andreas, additional, Krug, Axel, additional, Dannlowski, Udo, additional, Nenadić, Igor, additional, and Kircher, Tilo, additional
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- 2022
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19. Shared and Specific Patterns of Structural Brain Connectivity Across Affective and Psychotic Disorders
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Repple, Jonathan, Gruber, Marius, Mauritz, Marco, de Lange, Siemon C, Winter, Nils Ralf, Opel, Nils, Goltermann, Janik, Meinert, Susanne, Grotegerd, Dominik, Leehr, Elisabeth J, Enneking, Verena, Borgers, Tiana, Klug, Melissa, Lemke, Hannah, Waltemate, Lena, Thiel, Katharina, Winter, Alexandra, Breuer, Fabian, Grumbach, Pascal, Hofmann, Hannes, Stein, Frederike, Brosch, Katharina, Ringwald, Kai G, Pfarr, Julia, Thomas-Odenthal, Florian, Meller, Tina, Jansen, Andreas, Nenadic, Igor, Redlich, Ronny, Bauer, Jochen, Kircher, Tilo, Hahn, Tim, van den Heuvel, Martijn, Dannlowski, Udo, Repple, Jonathan, Gruber, Marius, Mauritz, Marco, de Lange, Siemon C, Winter, Nils Ralf, Opel, Nils, Goltermann, Janik, Meinert, Susanne, Grotegerd, Dominik, Leehr, Elisabeth J, Enneking, Verena, Borgers, Tiana, Klug, Melissa, Lemke, Hannah, Waltemate, Lena, Thiel, Katharina, Winter, Alexandra, Breuer, Fabian, Grumbach, Pascal, Hofmann, Hannes, Stein, Frederike, Brosch, Katharina, Ringwald, Kai G, Pfarr, Julia, Thomas-Odenthal, Florian, Meller, Tina, Jansen, Andreas, Nenadic, Igor, Redlich, Ronny, Bauer, Jochen, Kircher, Tilo, Hahn, Tim, van den Heuvel, Martijn, and Dannlowski, Udo
- Abstract
BACKGROUND: Altered brain structural connectivity has been implicated in the pathophysiology of psychiatric disorders including schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). However, it is unknown which part of these connectivity abnormalities are disorder specific and which are shared across the spectrum of psychotic and affective disorders. We investigated common and distinct brain connectivity alterations in a large sample (N = 1743) of patients with SZ, BD, or MDD and healthy control (HC) subjects.METHODS: This study examined diffusion-weighted imaging-based structural connectome topology in 720 patients with MDD, 112 patients with BD, 69 patients with SZ, and 842 HC subjects (mean age of all subjects: 35.7 years). Graph theory-based network analysis was used to investigate connectome organization. Machine learning algorithms were trained to classify groups based on their structural connectivity matrices.RESULTS: Groups differed significantly in the network metrics global efficiency, clustering, present edges, and global connectivity strength with a converging pattern of alterations between diagnoses (e.g., efficiency: HC > MDD > BD > SZ, false discovery rate-corrected p = .028). Subnetwork analysis revealed a common core of edges that were affected across all 3 disorders, but also revealed differences between disorders. Machine learning algorithms could not discriminate between disorders but could discriminate each diagnosis from HC. Furthermore, dysconnectivity patterns were found most pronounced in patients with an early disease onset irrespective of diagnosis.CONCLUSIONS: We found shared and specific signatures of structural white matter dysconnectivity in SZ, BD, and MDD, leading to commonly reduced network efficiency. These results showed a compromised brain communication across a spectrum of major psychiatric disorders.
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- 2022
20. Association between stressful life events and grey matter volume in the medial prefrontal cortex: A 2‐year longitudinal study
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Ringwald, Kai G., primary, Pfarr, Julia‐Katharina, additional, Stein, Frederike, additional, Brosch, Katharina, additional, Meller, Tina, additional, Thomas‐Odenthal, Florian, additional, Meinert, Susanne, additional, Waltemate, Lena, additional, Breuer, Fabian, additional, Winter, Alexandra, additional, Lemke, Hannah, additional, Grotegerd, Dominik, additional, Thiel, Katharina, additional, Bauer, Jochen, additional, Hahn, Tim, additional, Jansen, Andreas, additional, Dannlowski, Udo, additional, Krug, Axel, additional, Nenadić, Igor, additional, and Kircher, Tilo, additional
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- 2022
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21. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
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Schijven, Dick, primary, Postema, Merel C., additional, Fukunaga, Masaki, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, de Zwarte, Sonja M.C., additional, van Haren, Neeltje E.M., additional, Cahn, Wiepke, additional, Hulshoff Pol, Hilleke E., additional, Kahn, René S., additional, Ayesa-Arriola, Rosa, additional, Ortiz-García de la Foz, Víctor, additional, Tordesillas-Gutierrez, Diana, additional, Vázquez-Bourgon, Javier, additional, Crespo-Facorro, Benedicto, additional, Alnæs, Dag, additional, Dahl, Andreas, additional, Westlye, Lars T., additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Jönsson, Erik G., additional, Kochunov, Peter, additional, Bruggemann, Jason M., additional, Catts, Stanley V., additional, Michie, Patricia T., additional, Mowry, Bryan J., additional, Quidé, Yann, additional, Rasser, Paul E., additional, Schall, Ulrich, additional, Scott, Rodney J., additional, Carr, Vaughan J., additional, Green, Melissa J., additional, Henskens, Frans A., additional, Loughland, Carmel M., additional, Pantelis, Christos, additional, Weickert, Cynthia Shannon, additional, Weickert, Thomas W., additional, de Haan, Lieuwe, additional, Brosch, Katharina, additional, Pfarr, Julia-Katharina, additional, Ringwald, Kai G., additional, Stein, Frederike, additional, Jansen, Andreas, additional, Kircher, Tilo T.J., additional, Nenadic, Igor, additional, Krämer, Bernd, additional, Gruber, Oliver, additional, Satterthwaite, Theodore D., additional, Bustillo, Juan, additional, Mathalon, Daniel H., additional, Preda, Adrian, additional, Calhoun, Vince D., additional, Ford, Judith M., additional, Potkin, Steven G., additional, Chen, Jingxu, additional, Tan, Yunlong, additional, Wang, Zhiren, additional, Xiang, Hong, additional, Fan, Fengmei, additional, Bernardoni, Fabio, additional, Ehrlich, Stefan, additional, Fuentes-Claramonte, Paola, additional, Garcia-Leon, Maria Angeles, additional, Guerrero-Pedraza, Amalia, additional, Salvador, Raymond, additional, Sarró, Salvador, additional, Pomarol-Clotet, Edith, additional, Ciullo, Valentina, additional, Piras, Fabrizio, additional, Vecchio, Daniela, additional, Banaj, Nerisa, additional, Spalletta, Gianfranco, additional, Michielse, Stijn, additional, van Amelsvoort, Therese, additional, Dickie, Erin W., additional, Voineskos, Aristotle N., additional, Sim, Kang, additional, Ciufolini, Simone, additional, Dazzan, Paola, additional, Murray, Robin M., additional, Kim, Woo-Sung, additional, Chung, Young-Chul, additional, Andreou, Christina, additional, Schmidt, André, additional, Borgwardt, Stefan, additional, McIntosh, Andrew M., additional, Whalley, Heather C., additional, Lawrie, Stephen M., additional, du Plessis, Stefan, additional, Luckhoff, Hilmar K., additional, Scheffler, Freda, additional, Emsley, Robin, additional, Grotegerd, Dominik, additional, Lencer, Rebekka, additional, Dannlowski, Udo, additional, Edmond, Jesse T., additional, Rootes-Murdy, Kelly, additional, Stephen, Julia M., additional, Mayer, Andrew R., additional, Antonucci, Linda A., additional, Fazio, Leonardo, additional, Pergola, Giulio, additional, Bertolino, Alessandro, additional, Díaz-Caneja, Covadonga M., additional, Janssen, Joost, additional, Lois, Noemi G., additional, Arango, Celso, additional, Tomyshev, Alexander S., additional, Lebedeva, Irina, additional, Cervenka, Simon, additional, Sellgren, Carl M., additional, Georgiadis, Foivos, additional, Kirschner, Matthias, additional, Kaiser, Stefan, additional, Hajek, Tomas, additional, Skoch, Antonin, additional, Spaniel, Filip, additional, Kim, Minah, additional, Kwak, Yoo Bin, additional, Oh, Sanghoon, additional, Kwon, Jun Soo, additional, James, Anthony, additional, Bakker, Geor, additional, Knöchel, Christian, additional, Stäblein, Michael, additional, Oertel, Viola, additional, Uhlmann, Anne, additional, Howells, Fleur M., additional, Stein, Dan J., additional, Temmingh, Henk S., additional, Diaz-Zuluaga, Ana M., additional, Pineda-Zapata, Julian A., additional, López-Jaramillo, Carlos, additional, Homan, Stephanie, additional, Ji, Ellen, additional, Surbeck, Werner, additional, Homan, Philipp, additional, Fisher, Simon E., additional, Franke, Barbara, additional, Glahn, David C., additional, Gur, Ruben C., additional, Hashimoto, Ryota, additional, Jahanshad, Neda, additional, Luders, Eileen, additional, Medland, Sarah E., additional, Thompson, Paul M., additional, Turner, Jessica A., additional, van Erp, Theo G.M., additional, and Francks, Clyde, additional
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- 2022
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22. Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group
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Abé, Christoph, primary, Ching, Christopher R.K., additional, Liberg, Benny, additional, Lebedev, Alexander V., additional, Agartz, Ingrid, additional, Akudjedu, Theophilus N., additional, Alda, Martin, additional, Alnæs, Dag, additional, Alonso-Lana, Silvia, additional, Benedetti, Francesco, additional, Berk, Michael, additional, Bøen, Erlend, additional, Bonnin, Caterina del Mar, additional, Breuer, Fabian, additional, Brosch, Katharina, additional, Brouwer, Rachel M., additional, Canales-Rodríguez, Erick J., additional, Cannon, Dara M., additional, Chye, Yann, additional, Dahl, Andreas, additional, Dandash, Orwa, additional, Dannlowski, Udo, additional, Dohm, Katharina, additional, Elvsåshagen, Torbjørn, additional, Fisch, Lukas, additional, Fullerton, Janice M., additional, Goikolea, Jose M., additional, Grotegerd, Dominik, additional, Haatveit, Beathe, additional, Hahn, Tim, additional, Hajek, Tomas, additional, Heindel, Walter, additional, Ingvar, Martin, additional, Sim, Kang, additional, Kircher, Tilo T.J., additional, Lenroot, Rhoshel K., additional, Malt, Ulrik F., additional, McDonald, Colm, additional, McWhinney, Sean R., additional, Melle, Ingrid, additional, Meller, Tina, additional, Melloni, Elisa M.T., additional, Mitchell, Philip B., additional, Nabulsi, Leila, additional, Nenadić, Igor, additional, Opel, Nils, additional, Overs, Bronwyn J., additional, Panicalli, Francesco, additional, Pfarr, Julia-Katharina, additional, Poletti, Sara, additional, Pomarol-Clotet, Edith, additional, Radua, Joaquim, additional, Repple, Jonathan, additional, Ringwald, Kai G., additional, Roberts, Gloria, additional, Rodriguez-Cano, Elena, additional, Salvador, Raymond, additional, Sarink, Kelvin, additional, Sarró, Salvador, additional, Schmitt, Simon, additional, Stein, Frederike, additional, Suo, Chao, additional, Thomopoulos, Sophia I., additional, Tronchin, Giulia, additional, Vieta, Eduard, additional, Westlye, Lars T., additional, White, Adam G., additional, Yatham, Lakshmi N., additional, Zak, Nathalia, additional, Thompson, Paul M., additional, Andreassen, Ole A., additional, and Landén, Mikael, additional
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- 2022
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23. Genetic risk for psychiatric illness is associated with the number of hospitalizations of bipolar disorder patients
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Kalman, Janos L., primary, Papiol, Sergi, additional, Grigoroiu-Serbanescu, Maria, additional, Adorjan, Kristina, additional, Anderson-Schmidt, Heike, additional, Brosch, Katharina, additional, Budde, Monika, additional, Comes, Ashley L., additional, Gade, Katrin, additional, Forstner, Andreas, additional, Grotegerd, Dominik, additional, Hahn, Tim, additional, Heilbronner, Maria, additional, Heilbronner, Urs, additional, Heilmann-Heimbach, Stefanie, additional, Klöhn-Saghatolislam, Farah, additional, Kohshour, Mojtaba Oraki, additional, Meinert, Susanne, additional, Meller, Tina, additional, Mullins, Niamh, additional, Nenadić, Igor, additional, Nöthen, Markus M, additional, Pfarr, Julia-Katharina, additional, Reich-Erkelenz, Daniela, additional, Rietschel, Marcella, additional, Ringwald, Kai G., additional, Schaupp, Sabrina, additional, Schulte, Eva C., additional, Senner, Fanny, additional, Stein, Frederike, additional, Streit, Fabian, additional, Vogl, Thomas, additional, Falkai, Peter, additional, Dannlowski, Udo, additional, Kircher, Tilo, additional, Schulze, Thomas G., additional, and Andlauer, Till F.M., additional
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- 2022
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24. Which traits predict elevated distress during the Covid-19 pandemic? Results from a large, longitudinal cohort study with psychiatric patients and healthy controls
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Brosch, Katharina, primary, Meller, Tina, additional, Pfarr, Julia-Katharina, additional, Stein, Frederike, additional, Schmitt, Simon, additional, Ringwald, Kai G., additional, Waltemate, Lena, additional, Lemke, Hannah, additional, Thiel, Katharina, additional, Schrammen, Elisabeth, additional, Hülsmann, Carina, additional, Meinert, Susanne, additional, Dohm, Katharina, additional, Leehr, Elisabeth J., additional, Opel, Nils, additional, Krug, Axel, additional, Dannlowski, Udo, additional, Nenadić, Igor, additional, and Kircher, Tilo, additional
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- 2022
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25. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results across 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
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van Velzen, Laura S., primary, Dauvermann, Maria R., additional, Colic, Lejla, additional, Villa, Luca M., additional, Savage, Hannah S., additional, Toenders, Yara J., additional, Zhu, Alyssa H., additional, Bright, Joanna K., additional, Campos, Adrián I., additional, Salminen, Lauren, additional, Ambrogi, Sonia, additional, Ayesa-Arriola, Rosa, additional, Banaj, Nerisa, additional, Başgöze, Zeynep, additional, Bauer, Jochen, additional, Blair, Karina, additional, Blair, Robert James, additional, Brosch, Katharina, additional, Cheng, Yuqi, additional, Colle, Romain, additional, Connolly, Colm G., additional, Corruble, Emmanuelle, additional, Couvy-Duchesne, Baptiste, additional, Crespo-Facorro, Benedicto, additional, Cullen, Kathryn R., additional, Dannlowski, Udo, additional, Davey, Christopher G., additional, Dohm, Katharina, additional, Fullerton, Janice M., additional, Gonul, Ali Saffet, additional, Gotlib, Ian H., additional, Grotegerd, Dominik, additional, Hahn, Tim, additional, Harrison, Ben J., additional, He, Mengxin, additional, Hickie, Ian B., additional, Ho, Tiffany C., additional, Iorfino, Frank, additional, Jansen, Andreas, additional, Jollant, Fabrice, additional, Kircher, Tilo, additional, Klimes-Dougan, Bonnie, additional, Klug, Melissa, additional, Leehr, Elisabeth J., additional, Lippard, Elizabeth T.C., additional, McLaughlin, Katie A., additional, Meinert, Susanne, additional, Miller, Adam Bryant, additional, Mitchell, Philip B., additional, Mwangi, Benson, additional, Nenadić, Igor, additional, Ojha, Amar, additional, Overs, Bronwyn J., additional, Pfarr, Julia-Katharina, additional, Piras, Fabrizio, additional, Ringwald, Kai G., additional, Roberts, Gloria, additional, Romer, Georg, additional, Sanches, Marsal, additional, Sheridan, Margaret A., additional, Soares, Jair C, additional, Spalletta, Gianfranco, additional, Stein, Frederike, additional, Teresi, Giana I., additional, Tordesillas-Gutiérrez, Diana, additional, Uyar-Demir, Aslihan, additional, van der Wee, Nic J.A., additional, van der Werff, Steven J., additional, Vermeiren, Robert R.J.M., additional, Winter, Alexandra, additional, Wu, Mon-Ju, additional, Yang, Tony T., additional, Thompson, Paul M., additional, Rentería, Miguel E., additional, Jahanshad, Neda, additional, Blumberg, Hilary P., additional, van Harmelen, Anne-Laura, additional, and Schmaal, Lianne, additional
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- 2021
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26. Temporal stability and state-dependence of retrospective self-reports of childhood maltreatment in major depression: a two-year longitudinal analysis of the childhood trauma questionnaire
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Goltermann, Janik, primary, Meinert, Susanne, additional, Hülsmann, Carina, additional, Dohm, Katharina, additional, Grotegerd, Dominik, additional, Redlich, Ronny, additional, Waltemate, Lena, additional, Lemke, Hannah, additional, Thiel, Katharina, additional, Mehler, David M. A., additional, Enneking, Verena, additional, Borgers, Tiana, additional, Repple, Jonathan, additional, Gruber, Marius, additional, Winter, Nils, additional, Hahn, Tim, additional, Brosch, Katharina, additional, Meller, Tina, additional, Ringwald, Kai G., additional, Schmitt, Simon, additional, Stein, Frederike, additional, Pfarr, Julia-Katharina, additional, Krug, Axel, additional, Nenadić, Igor, additional, Kircher, Tilo, additional, Opel, Nils, additional, and Dannlowski, Udo, additional
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- 2021
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27. Which traits predict elevated distress during the Covid-19 pandemic? Results from a large, longitudinal cohort study with psychiatric patients and healthy controls
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Brosch, Katharina, primary, Meller, Tina, additional, Pfarr, Julia-Katharina, additional, Stein, Frederike, additional, Schmitt, Simon, additional, Ringwald, Kai G., additional, Waltemate, Lena, additional, Lemke, Hannah, additional, Thiel, Katharina, additional, Schrammen, Elisabeth, additional, Hülsmann, Carina, additional, Meinert, Susanne, additional, Dohm, Katharina, additional, Leehr, Elisabeth J., additional, Opel, Nils, additional, Krug, Axel, additional, Dannlowski, Udo, additional, Nenadić, Igor, additional, and Kircher, Tilo, additional
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- 2021
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28. Interaction of developmental factors and ordinary stressful life events on brain structure in adults
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Ringwald, Kai G., primary, Meller, Tina, additional, Schmitt, Simon, additional, Andlauer, Till F.M., additional, Stein, Frederike, additional, Brosch, Katharina, additional, Pfarr, Julia-Katharina, additional, Steinsträter, Olaf, additional, Meinert, Susanne, additional, Lemke, Hannah, additional, Waltemate, Lena, additional, Thiel, Katharina, additional, Grotegerd, Dominik, additional, Enneking, Verena, additional, Klug, Melissa, additional, Jansen, Andreas, additional, Forstner, Andreas J., additional, Streit, Fabian, additional, Witt, Stephanie H., additional, Rietschel, Marcella, additional, Müller-Myhsok, Bertram, additional, Nöthen, Markus M., additional, Dannlowski, Udo, additional, Krug, Axel, additional, Nenadić, Igor, additional, and Kircher, Tilo, additional
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- 2021
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29. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals
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Sean R, McWhinney, Christoph, Abé, Martin, Alda, Francesco, Benedetti, Erlend, Bøen, Caterina, Del Mar Bonnin, Tiana, Borgers, Katharina, Brosch, Erick J, Canales-Rodríguez, Dara M, Cannon, Udo, Dannlowski, Ana M, Diaz-Zuluaga, Lorielle, Dietze, Torbjørn, Elvsåshagen, Lisa T, Eyler, Janice M, Fullerton, Jose M, Goikolea, Janik, Goltermann, Dominik, Grotegerd, Bartholomeus C M, Haarman, Tim, Hahn, Fleur M, Howells, Martin, Ingvar, Tilo T J, Kircher, Axel, Krug, Rayus T, Kuplicki, Mikael, Landén, Hannah, Lemke, Benny, Liberg, Carlos, Lopez-Jaramillo, Ulrik F, Malt, Fiona M, Martyn, Elena, Mazza, Colm, McDonald, Genevieve, McPhilemy, Sandra, Meier, Susanne, Meinert, Tina, Meller, Elisa M T, Melloni, Philip B, Mitchell, Leila, Nabulsi, Igor, Nenadic, Nils, Opel, Roel A, Ophoff, Bronwyn J, Overs, Julia-Katharina, Pfarr, Julian A, Pineda-Zapata, Edith, Pomarol-Clotet, Joaquim, Raduà, Jonathan, Repple, Maike, Richter, Kai G, Ringwald, Gloria, Roberts, Alex, Ross, Raymond, Salvador, Jonathan, Savitz, Simon, Schmitt, Peter R, Schofield, Kang, Sim, Dan J, Stein, Frederike, Stein, Henk S, Temmingh, Katharina, Thiel, Sophia I, Thomopoulos, Neeltje E M, van Haren, Holly, Van Gestel, Cristian, Vargas, Eduard, Vieta, Annabel, Vreeker, Lena, Waltemate, Lakshmi N, Yatham, Christopher R K, Ching, Ole A, Andreassen, Paul M, Thompson, Tomas, Hajek, Mcwhinney, Sean R, Abé, Christoph, Alda, Martin, Benedetti, Francesco, Bøen, Erlend, Del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J, Cannon, Dara M, Dannlowski, Udo, Diaz-Zuluaga, Ana M, Dietze, Lorielle, Elvsåshagen, Torbjørn, Eyler, Lisa T, Fullerton, Janice M, Goikolea, Jose M, Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C M, Hahn, Tim, Howells, Fleur M, Ingvar, Martin, Kircher, Tilo T J, Krug, Axel, Kuplicki, Rayus T, Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlo, Malt, Ulrik F, Martyn, Fiona M, Mazza, Elena, Mcdonald, Colm, Mcphilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M T, Mitchell, Philip B, Nabulsi, Leila, Nenadic, Igor, Opel, Nil, Ophoff, Roel A, Overs, Bronwyn J, Pfarr, Julia-Katharina, Pineda-Zapata, Julian A, Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G, Roberts, Gloria, Ross, Alex, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R, Sim, Kang, Stein, Dan J, Stein, Frederike, Temmingh, Henk S, Thiel, Katharina, Thomopoulos, Sophia I, van Haren, Neeltje E M, Van Gestel, Holly, Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N, Ching, Christopher R K, Andreassen, Ole, Thompson, Paul M, Hajek, Tomas, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry, Child and Adolescent Psychiatry / Psychology, and Clinical Child and Family Studies
- Subjects
obesity ,Bipolar Disorder ,body mass index ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,SCHIZOPHRENIA ,Cluster Analysis ,Humans ,BRAIN ,Biological Psychiatry ,Body mass index ,GRAY-MATTER VOLUME ,METABOLIC SYNDROME ,2. Zero hunger ,MAJOR DEPRESSIVE DISORDER ,INSULIN-RESISTANCE ,ABNORMALITIES ,1ST-EPISODE ,heterogeneit ,surface area ,cortical thickness ,Magnetic Resonance Imaging ,Temporal Lobe ,3. Good health ,030227 psychiatry ,Psychiatry and Mental health ,bipolar disorders ,WHITE ,heterogeneity ,030217 neurology & neurosurgery - Abstract
Aims: Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry. Methods: We obtained body mass index (BMI) and magnetic resonance imaging-derived regional cortical thickness, surface area from 836 bipolar disorders (BD) and 1600 control individuals from 14 sites within the ENIGMA-BD Working Group. We identified regionally specific profiles of cortical thickness using K-means clustering and studied clinical characteristics associated with individual cortical profiles. Results: We detected two clusters based on similarities among participants in cortical thickness. The lower thickness cluster (46.8% of the sample) showed thinner cortex, especially in the frontal and temporal lobes and was associated with diagnosis of BD, higher BMI, and older age. BD individuals in the low thickness cluster were more likely to have the diagnosis of bipolar disorder I and less likely to be treated with lithium. In contrast, clustering based on similarities in the cortical surface area was unrelated to BD or BMI and only tracked age and sex. Conclusions: We provide evidence that both BD and obesity are associated with similar alterations in cortical thickness, but not surface area. The fact that obesity increased the chance of having low cortical thickness could explain differences in cortical measures among people with BD. The thinner cortex in individuals with higher BMI, which was additive and similar to the BD-associated alterations, may suggest that treating obesity could lower the extent of cortical thinning in BD.
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- 2022
30. Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants.
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McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze LMF, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Jahanshad N, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen OA, Thompson PM, and Hajek T
- Abstract
Background: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact., Methods: We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations., Results: BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI., Conclusions: We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.
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- 2023
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31. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals.
- Author
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McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Diaz-Zuluaga AM, Dietze L, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, McPhilemy G, Meier S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, Overs BJ, Pfarr JK, Pineda-Zapata JA, Pomarol-Clotet E, Raduà J, Repple J, Richter M, Ringwald KG, Roberts G, Ross A, Salvador R, Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, Thomopoulos SI, van Haren NEM, Van Gestel H, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen OA, Thompson PM, and Hajek T
- Subjects
- Body Mass Index, Cluster Analysis, Humans, Magnetic Resonance Imaging, Obesity complications, Obesity diagnostic imaging, Temporal Lobe pathology, Bipolar Disorder diagnosis
- Abstract
Aims: Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry., Methods: We obtained body mass index (BMI) and magnetic resonance imaging-derived regional cortical thickness, surface area from 836 bipolar disorders (BD) and 1600 control individuals from 14 sites within the ENIGMA-BD Working Group. We identified regionally specific profiles of cortical thickness using K-means clustering and studied clinical characteristics associated with individual cortical profiles., Results: We detected two clusters based on similarities among participants in cortical thickness. The lower thickness cluster (46.8% of the sample) showed thinner cortex, especially in the frontal and temporal lobes and was associated with diagnosis of BD, higher BMI, and older age. BD individuals in the low thickness cluster were more likely to have the diagnosis of bipolar disorder I and less likely to be treated with lithium. In contrast, clustering based on similarities in the cortical surface area was unrelated to BD or BMI and only tracked age and sex., Conclusions: We provide evidence that both BD and obesity are associated with similar alterations in cortical thickness, but not surface area. The fact that obesity increased the chance of having low cortical thickness could explain differences in cortical measures among people with BD. The thinner cortex in individuals with higher BMI, which was additive and similar to the BD-associated alterations, may suggest that treating obesity could lower the extent of cortical thinning in BD., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2022
- Full Text
- View/download PDF
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