5 results on '"Ripollés E"'
Search Results
2. Análisis de las pinturas murales de la capilla de los Santos Corporales de Daroca (Zaragoza)
- Author
-
Perrero, J.L., Roldan, C., Juanes, David, Alvaret, M., Rollano, Empar, Tato, A., Ripollés, E., and Núñez, M.
- Abstract
La capilla de los Santos Corporales, ubicada en la Iglesia Colegial de Santa María de Daroca (Zaragoza), alberga una muestra importante de pintura mural medieval de los siglos XIV y XVI. Durante su reciente proceso de restauración, la Unidad de Arqueometría del I.C.M.U.V. ha analizado los pigmentos que inte gran sus pinturas murales. Se han efectuado análisis in situ de fluorescencia de rayos X dispersiva en energía (EDXRF) de una pintura mural que forma parte de un ábside románico del s. XIV, de un relieve que forma parte del retablo relicario cuya policromía data del XVI y de la decoración que se le dio a las bóvedas de las capillas del s. XVI. Adicionalmente se tomaron muestras de pigmentos procedentes de la bóveda del s. XIV que han sido analizadas mediante EDXRF, difracción de ra yos X (XRD) y microscopía electrónica de bamdo (SEM).
- Published
- 1999
3. Profile of plasma microRNAs as a potential biomarker of Wilson's disease.
- Author
-
Sánchez-Monteagudo A, Ripollés E, Murillo O, Domènech S, Álvarez-Sauco M, Girona E, Sastre-Bataller I, Bono A, García-Villarreal L, Tugores A, García-García F, González-Aseguinolaza G, Berenguer M, and Espinós C
- Subjects
- Humans, Animals, Male, Female, Mice, Adult, MicroRNAs blood, MicroRNAs genetics, Disease Progression, Mice, Knockout, Liver pathology, Liver metabolism, Prognosis, Disease Models, Animal, Alanine Transaminase blood, Aspartate Aminotransferases blood, Young Adult, Adolescent, Cohort Studies, gamma-Glutamyltransferase blood, Case-Control Studies, Circulating MicroRNA blood, Circulating MicroRNA genetics, Hepatolenticular Degeneration genetics, Hepatolenticular Degeneration blood, Hepatolenticular Degeneration diagnosis, Copper-Transporting ATPases genetics, Biomarkers blood
- Abstract
Background: Wilson's disease (WD) is a rare condition resulting from autosomal recessive mutations in ATP7B, a copper transporter, manifesting with hepatic, neurological, and psychiatric symptoms. Timely diagnosis and appropriate treatment yield a positive prognosis, while delayed identification and/or insufficient therapy lead to a poor outcome. Our aim was to establish a prognostic method for WD by characterising biomarkers based on circulating microRNAs., Methods: We conducted investigations across three cohorts: discovery, validation (comprising unrelated patients), and follow-up (revisiting the discovery cohort 3 years later). All groups were compared to age- and gender-matched controls. Plasma microRNAs were analysed via RNA sequencing in the discovery cohort and subsequently validated using quantitative PCR in all three cohorts. To assess disease progression, we examined the microRNA profile in Atp7b
-/- mice, analysing serum samples from 6 to 44 weeks of age and liver samples at three time points: 20, 30, and 40 weeks of age., Results: In patients, elevated levels of the signature microRNAs (miR-122-5p, miR-192-5p, and miR-885-5p) correlated with serum activities of aspartate transaminase, alanine aminotransferase and gamma-glutamyl transferase. In Atp7b-/- mice, levels of miR-122-5p and miR-192-5p (miR-885-5p lacking a murine orthologue) increased from 12 weeks of age in serum, while exhibiting fluctuations in the liver, possibly attributable to hepatocyte regenerative capacity post-injury and the release of hepatic microRNAs into the bloodstream., Conclusions: The upregulation of the signature miR-122-5p, miR-192-5p, and miR-885-5p in patients and their correlation with liver disease progression in WD mice support their potential as biomarkers of WD., (© 2024. The Author(s).)- Published
- 2024
- Full Text
- View/download PDF
4. Wilson's Disease: Facing the Challenge of Diagnosing a Rare Disease.
- Author
-
Sánchez-Monteagudo A, Ripollés E, Berenguer M, and Espinós C
- Abstract
Wilson disease (WD) is a rare disorder caused by mutations in ATP7B , which leads to the defective biliary excretion of copper. The subsequent gradual accumulation of copper in different organs produces an extremely variable clinical picture, which comprises hepatic, neurological psychiatric, ophthalmological, and other disturbances. WD has a specific treatment, so that early diagnosis is crucial to avoid disease progression and its devastating consequences. The clinical diagnosis is based on the Leipzig score, which considers clinical, histological, biochemical, and genetic data. However, even patients with an initial WD diagnosis based on a high Leipzig score may harbor other conditions that mimic the WD's phenotype (Wilson-like). Many patients are diagnosed using current available methods, but others remain in an uncertain area because of bordering ceruloplasmin levels, inconclusive genetic findings and unclear phenotypes. Currently, the available biomarkers for WD are ceruloplasmin and copper in the liver or in 24 h urine, but they are not solid enough. Therefore, the characterization of biomarkers that allow us to anticipate the evolution of the disease and the monitoring of new drugs is essential to improve its diagnosis and prognosis.
- Published
- 2021
- Full Text
- View/download PDF
5. Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson's disease based on DJ-1 deficiency.
- Author
-
Solana-Manrique C, Sanz FJ, Ripollés E, Bañó MC, Torres J, Muñoz-Soriano V, and Paricio N
- Subjects
- Animals, Drosophila genetics, Drosophila metabolism, Glycolysis, Humans, Nerve Tissue Proteins metabolism, Oxidative Stress, Protein Deglycase DJ-1 genetics, Drosophila Proteins genetics, Parkinson Disease drug therapy, Parkinson Disease genetics
- Abstract
Parkinson's disease (PD) is a neurodegenerative debilitating disorder characterized by progressive disturbances in motor, autonomic and psychiatric functions. One of the genes involved in familial forms of the disease is DJ-1, whose mutations cause early-onset PD. Besides, it has been shown that an over-oxidized and inactive form of the DJ-1 protein is found in brains of sporadic PD patients. Interestingly, the DJ-1 protein plays an important role in cellular defense against oxidative stress and also participates in mitochondrial homeostasis. Valuable insights into potential PD pathogenic mechanisms involving DJ-1 have been obtained from studies in cell and animal PD models based on DJ-1 deficiency such as Drosophila. Flies mutant for the DJ-1β gene, the Drosophila ortholog of human DJ-1, exhibited disease-related phenotypes such as motor defects, increased reactive oxygen species production and high levels of protein carbonylation. In the present study, we demonstrate that DJ-1β mutants also show a significant increase in the activity of several regulatory glycolytic enzymes. Similar results were obtained in DJ-1-deficient SH-SY5Y neuroblastoma cells, thus suggesting that loss of DJ-1 function leads to an increase in the glycolytic rate. In such a scenario, an enhancement of the glycolytic pathway could be a protective mechanism to decrease ROS production by restoring ATP levels, which are decreased due to mitochondrial dysfunction. Our results also show that meclizine and dimethyl fumarate, two FDA-approved compounds with different clinical applications, are able to attenuate PD-related phenotypes in both models. Moreover, we found that they may exert their beneficial effect by increasing glycolysis through the activation of key glycolytic enzymes. Taken together, these results are consistent with the idea that increasing glycolysis could be a potential disease-modifying strategy for PD, as recently suggested. Besides, they also support further evaluation and potential repurposing of meclizine and dimethyl fumarate as modulators of energy metabolism for neuroprotection in PD., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.