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2. Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop

Author

Whittaker, Jackie L., Kalsoum, Raneem, Bilzon, James, Conaghan, Philip G., Crossley, Kay, Dodge, George R., Getgood, Alan, Li, Xiaojuan, Losina, Elena, Mason, Deborah J., Pietrosimone, Brian, Risberg, May Arna, Roemer, Frank, Felson, David, Culvenor, Adam G., Meuffels, Duncan, Gerwin, Nicole, Simon, Lee S., Lohmander, L. Stefan, Englund, Martin, and Watt, Fiona E.

Published
2024
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4. Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis

Author

Brown, Jenny, Ingram, Carol, Hickson, Sheila, Taylor, Robert, Walker, Christine, Abbott, J Haxby, Allen, Kelli, Bennell, Kim, Bossen, Daniel, Chaipinyo, Kanda, Cochrane, Tom, de Rooij, Mariëtte, Risberg, May Arna, Fitzgerald, G Kelley, French, Helen, Hale, Leigh, Henriksen, Marius, Hinman, Rana S, Hopman-Rock, Marijke, Hurley, Michael, Keogh, Justin, Veenhof, Cindy, Knoop, Jesper, Krauss, Inga, Levinger, Pazit, McCarthy, Christopher, Messier, Stephen P, Heinonen, Ari, Osteras, Havard, Anwer, Shahnawaz, Lacerda, Ana Cristina R, Ganesh, Shankar, Steinhilber, Benjamin, Suzuki, Yusuke, Hunt, Michael A, Talbot, Laura, Teirlinck, Carolien, Doherty, Michael, Tsai, Pao-Feng, Wallis, Jason A, Yilmaz Menek, Merve, Holden, Melanie A, Hattle, Miriam, Runhaar, Jos, Riley, Richard D, Healey, Emma L, Quicke, Jonathan, van der Windt, Danielle A, Dziedzic, Krysia, van Middelkoop, Marienke, Burke, Danielle, Corp, Nadia, Legha, Amardeep, Bierma-Zeinstra, Sita, and Foster, Nadine E

Published
2023
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8. Toward designing human intervention studies to prevent osteoarthritis after knee injury:A report from an interdisciplinary OARSI 2023 workshop

Author

Whittaker, Jackie L., Kalsoum, Raneem, Bilzon, James, Conaghan, Philip G., Crossley, Kay, Dodge, George R., Getgood, Alan, Li, Xiaojuan, Losina, Elena, Mason, Deborah J., Pietrosimone, Brian, Risberg, May Arna, Roemer, Frank, Felson, David, Culvenor, Adam G., Meuffels, Duncan, Gerwin, Nicole, Simon, Lee S., Lohmander, L. Stefan, Englund, Martin, Watt, Fiona E., Whittaker, Jackie L., Kalsoum, Raneem, Bilzon, James, Conaghan, Philip G., Crossley, Kay, Dodge, George R., Getgood, Alan, Li, Xiaojuan, Losina, Elena, Mason, Deborah J., Pietrosimone, Brian, Risberg, May Arna, Roemer, Frank, Felson, David, Culvenor, Adam G., Meuffels, Duncan, Gerwin, Nicole, Simon, Lee S., Lohmander, L. Stefan, Englund, Martin, and Watt, Fiona E.

Abstract

Objective: The global impact of osteoarthritis is growing. Currently no disease modifying osteoarthritis drugs/therapies exist, increasing the need for preventative strategies. Knee injuries have a high prevalence, distinct onset, and strong independent association with post-traumatic osteoarthritis (PTOA). Numerous groups are embarking upon research that will culminate in clinical trials to assess the effect of interventions to prevent knee PTOA despite challenges and lack of consensus about trial design in this population. Our objectives were to improve awareness of knee PTOA prevention trial design and discuss state-of-the art methods to address the unique opportunities and challenges of these studies. Design: An international interdisciplinary group developed a workshop, hosted at the 2023 Osteoarthritis Research Society International Congress. Here we summarize the workshop content and outputs, with the goal of moving the field of PTOA prevention trial design forward. Results: Workshop highlights included discussions about target population (considering risk, homogeneity, and possibility of modifying osteoarthritis outcome); target treatment (considering delivery, timing, feasibility and effectiveness); comparators (usual care, placebo), and primary symptomatic outcomes considering surrogates and the importance of knee function and symptoms other than pain to this population. Conclusions: Opportunities to test multimodal PTOA prevention interventions across preclinical models and clinical trials exist. As improving symptomatic outcomes aligns with patient and regulator priorities, co-primary symptomatic (single or aggregate/multidimensional outcome considering function and symptoms beyond pain) and structural/physiological outcomes may be appropriate for these trials. To ensure PTOA prevention trials are relevant and acceptable to all stakeholders, future research should address critical knowledge gaps and challenges.

Published
2024

11. 23 Exploring rehabilitation following periacetabular osteotomy for acetabular dysplasia: a qualitative study on patients’ challenges, aspirations and expectations

Author

Jacobsen, Julie Sandell, primary, O´Brien, Michael JM, additional, Christensen, Jeanette Reffstrup, additional, Risberg, May Arna, additional, Lachlan, Milne, additional, Balakumar, Jitendra, additional, Jakobsen, Stig Storgaard, additional, Mechlenburg, Inger, additional, and Kemp, Joanne, additional

Published
2024
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12. Risk Factors for the Development of Osteoarthritis Across the Lifespan: A Systematic Review and Meta-Analysis

Author

Duong, Vicky, primary, Abdel Shaheed, Christina, additional, Ferreira, Manuela L., additional, Narayan, Sujita W., additional, Venkatesha, Venkatesha, additional, Hunter, David. J., additional, Zhu, Jimmy, additional, Atukorala, Inoshi, additional, Kobayashi, Sarah, additional, Goh, Siew Li, additional, Brigs, Andrew, additional, Cross, Marita, additional, Espinosa-Morales, Rolando, additional, Fu, Kai, additional, Guillemin, Francis, additional, Keefe, Francis J., additional, Lohmander, L. Stefan, additional, March, Lyn, additional, Milne, George, additional, Mei, Yifang, additional, Mobasheri, Ali, additional, Namane, Mosedi, additional, Peat, George, additional, Risberg, May Arna, additional, Sharma, Saurab, additional, Sit, Regina WS, additional, Telles, Rosa Weiss, additional, Zhang, Yuqing, additional, and Cooper, Cyrus, additional

Published
2024
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16. Nonoperative Management of ACL Rupture

Author

Snyder-Mackler, Lynn, Arundale, Amelia, Failla, Mathew, Wellsandt, Elizabeth, Grindem, Hege, Ricci, Margherita, Villa, Stefano Della, Risberg, May Arna, Nakamura, Norimasa, editor, Zaffagnini, Stefano, editor, Marx, Robert G., editor, and Musahl, Volker, editor

Published
2017
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18. Establishing outcome measures in early knee osteoarthritis

Author

Emery, Carolyn A., Whittaker, Jackie L., Mahmoudian, Armaghan, Lohmander, L. Stefan, Roos, Ewa M., Bennell, Kim L., Toomey, Clodagh M., Reimer, Raylene A., Thompson, Dylan, Ronsky, Janet L., Kuntze, Gregor, Lloyd, David G., Andriacchi, Thomas, Englund, Martin, Kraus, Virginia B., Losina, Elena, Bierma-Zeinstra, Sita, Runhaar, Jos, Peat, George, Luyten, Frank P., Snyder-Mackler, Lynn, Risberg, May Arna, Mobasheri, Ali, Guermazi, Ali, Hunter, David J., and Arden, Nigel K.

Published
2019
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19. Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis

Author

Holden, Melanie A, primary, Hattle, Miriam, additional, Runhaar, Jos, additional, Riley, Richard D, additional, Healey, Emma L, additional, Quicke, Jonathan, additional, van der Windt, Danielle A, additional, Dziedzic, Krysia, additional, van Middelkoop, Marienke, additional, Burke, Danielle, additional, Corp, Nadia, additional, Legha, Amardeep, additional, Bierma-Zeinstra, Sita, additional, Foster, Nadine E, additional, Brown, Jenny, additional, Ingram, Carol, additional, Hickson, Sheila, additional, Taylor, Robert, additional, Walker, Christine, additional, Abbott, J Haxby, additional, Allen, Kelli, additional, Bennell, Kim, additional, Bossen, Daniel, additional, Chaipinyo, Kanda, additional, Cochrane, Tom, additional, de Rooij, Mariëtte, additional, Risberg, May Arna, additional, Fitzgerald, G Kelley, additional, French, Helen, additional, Hale, Leigh, additional, Henriksen, Marius, additional, Hinman, Rana S, additional, Hopman-Rock, Marijke, additional, Hurley, Michael, additional, Keogh, Justin, additional, Veenhof, Cindy, additional, Knoop, Jesper, additional, Krauss, Inga, additional, Levinger, Pazit, additional, McCarthy, Christopher, additional, Messier, Stephen P, additional, Heinonen, Ari, additional, Osteras, Havard, additional, Anwer, Shahnawaz, additional, Lacerda, Ana Cristina R, additional, Ganesh, Shankar, additional, Steinhilber, Benjamin, additional, Suzuki, Yusuke, additional, Hunt, Michael A, additional, Talbot, Laura, additional, Teirlinck, Carolien, additional, Doherty, Michael, additional, Tsai, Pao-Feng, additional, Wallis, Jason A, additional, and Yilmaz Menek, Merve, additional

Published
2023
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21. The Delaware‐Oslo ACL Cohort treatment algorithm yields superior outcomes to usual care 9–12 years after anterior cruciate ligament reconstruction.

Author

Urhausen, Anouk P., Grindem, Hege, Engebretsen, Lars, Grävare Silbernagel, Karin, Axe, Michael J., Snyder‐Mackler, Lynn, and Risberg, May Arna

Subjects
ANTERIOR cruciate ligament surgery, PREOPERATIVE education, KNEE pain, PREHABILITATION, KNEE osteoarthritis, PATIENT reported outcome measures, PATIENT education
Abstract

Purpose: Patient‐reported outcomes were compared between participants who followed the treatment algorithm of the Delaware‐Oslo ACL Cohort, consisting of progressive preoperative and postoperative rehabilitation, patient education, clinical testing and shared decision‐making about treatment choice, and those who followed usual care 9–12 years after anterior cruciate ligament reconstruction (ACLR). Methods: Participants with primary ACLR were included from the Norwegian arm of the Delaware‐Oslo ACL Cohort and the Norwegian Knee Ligament Registry (usual care). The Knee Injury and Osteoarthritis Outcome Score (KOOS) subscale scores and the International Knee Documentation Committee‐Subjective Knee Form (IKDC‐SKF) scores were compared. KOOS scores for the usual care group were converted to IKDC‐SKF scores with recently published validated crosswalk. The percentages of participants with scores above predefined thresholds for patient acceptable symptom state (PASS) were also calculated. Results: Eighty of 100 (80%) participants from the Delaware‐Oslo ACL Cohort and 1588 of 3248 (49%) from the usual care group participated in the follow‐up. Participants from the Delaware‐Oslo ACL Cohort had higher KOOS subscale (p < 0.001) and IKDC‐SKF scores (p < 0.001), and a higher percentage reached PASS (84%–96% vs. 62%–76%, p ≤ 0.002) for KOOS Pain, symptoms, activities of daily living and sports compared to the usual care group. No significant differences were found for KOOS quality of life scores (not significant [n.s.]) or PASS percentages (80% vs. 74%, n.s.). Conclusion: Participants with ACLR who followed the Delaware‐Oslo ACL Cohort treatment algorithm had reduced knee symptoms, superior function and higher percentages of satisfactory outcomes than participants who followed usual care. Level of Evidence: Level II. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis

Author

Holden, Melanie A, Hattle, Miriam, Runhaar, Jos, Riley, Richard D, Healey, Emma L, Quicke, Jonathan, van der Windt, Danielle A, Dziedzic, Krysia, van Middelkoop, Marienke, Burke, Danielle, Corp, Nadia, Legha, Amardeep, Bierma-Zeinstra, Sita, Foster, Nadine E, Brown, Jenny, Ingram, Carol, Hickson, Sheila, Taylor, Robert, Walker, Christine, Abbott, J Haxby, Allen, Kelli, Bennell, Kim, Bossen, Daniel, Chaipinyo, Kanda, Cochrane, Tom, de Rooij, Mariëtte, Risberg, May Arna, Fitzgerald, G Kelley, French, Helen, Hale, Leigh, Henriksen, Marius, Hinman, Rana S, Hopman-Rock, Marijke, Hurley, Michael, Keogh, Justin, Veenhof, Cindy, Knoop, Jesper, Krauss, Inga, Levinger, Pazit, McCarthy, Christopher, Messier, Stephen P, Heinonen, Ari, Osteras, Havard, Anwer, Shahnawaz, Lacerda, Ana Cristina R, Ganesh, Shankar, Steinhilber, Benjamin, Suzuki, Yusuke, Hunt, Michael A, Talbot, Laura, Teirlinck, Carolien, Doherty, Michael, Tsai, Pao-Feng, Wallis, Jason A, Yilmaz Menek, Merve, Holden, Melanie A, Hattle, Miriam, Runhaar, Jos, Riley, Richard D, Healey, Emma L, Quicke, Jonathan, van der Windt, Danielle A, Dziedzic, Krysia, van Middelkoop, Marienke, Burke, Danielle, Corp, Nadia, Legha, Amardeep, Bierma-Zeinstra, Sita, Foster, Nadine E, Brown, Jenny, Ingram, Carol, Hickson, Sheila, Taylor, Robert, Walker, Christine, Abbott, J Haxby, Allen, Kelli, Bennell, Kim, Bossen, Daniel, Chaipinyo, Kanda, Cochrane, Tom, de Rooij, Mariëtte, Risberg, May Arna, Fitzgerald, G Kelley, French, Helen, Hale, Leigh, Henriksen, Marius, Hinman, Rana S, Hopman-Rock, Marijke, Hurley, Michael, Keogh, Justin, Veenhof, Cindy, Knoop, Jesper, Krauss, Inga, Levinger, Pazit, McCarthy, Christopher, Messier, Stephen P, Heinonen, Ari, Osteras, Havard, Anwer, Shahnawaz, Lacerda, Ana Cristina R, Ganesh, Shankar, Steinhilber, Benjamin, Suzuki, Yusuke, Hunt, Michael A, Talbot, Laura, Teirlinck, Carolien, Doherty, Michael, Tsai, Pao-Feng, Wallis, Jason A, and Yilmaz Menek, Merve

Abstract

Background Many international clinical guidelines recommend therapeutic exercise as a core treatment for knee and hip osteoarthritis. We aimed to identify individual patient-level moderators of the effect of therapeutic exercise for reducing pain and improving physical function in people with knee osteoarthritis, hip osteoarthritis, or both. Methods We did a systematic review and individual participant data (IPD) meta-analysis of randomised controlled trials comparing therapeutic exercise with non-exercise controls in people with knee osteoathritis, hip osteoarthritis, or both. We searched ten databases from March 1, 2012, to Feb 25, 2019, for randomised controlled trials comparing the effects of exercise with non-exercise or other exercise controls on pain and physical function outcomes among people with knee osteoarthritis, hip osteoarthritis, or both. IPD were requested from leads of all eligible randomised controlled trials. 12 potential moderators of interest were explored to ascertain whether they were associated with short-term (12 weeks), medium-term (6 months), and long-term (12 months) effects of exercise on self-reported pain and physical function, in comparison with non-exercise controls. Overall intervention effects were also summarised. This study is prospectively registered on PROSPERO (CRD42017054049). Findings Of 91 eligible randomised controlled trials that compared exercise with non-exercise controls, IPD from 31 randomised controlled trials (n=4241 participants) were included in the meta-analysis. Randomised controlled trials included participants with knee osteoarthritis (18 [58%] of 31 trials), hip osteoarthritis (six [19%]), or both (seven [23%]) and tested heterogeneous exercise interventions versus heterogeneous non-exercise controls, with variable risk of bias. Summary meta-analysis results showed that, on average, compared with non-exercise controls, therapeutic exercise reduced pain on a standardised 0–100 scale (with 100 corresponding to

Published
2023

27. OPTIKNEE 2022: consensus recommendations to optimise knee health after traumatic knee injury to prevent osteoarthritis

Author

Whittaker, Jackie L, primary, Culvenor, Adam G, additional, Juhl, Carsten Bogh, additional, Berg, Bjørnar, additional, Bricca, Alessio, additional, Filbay, Stephanie Rose, additional, Holm, Pætur, additional, Macri, Erin, additional, Urhausen, Anouk P, additional, Ardern, Clare L, additional, Bruder, Andrea M, additional, Bullock, Garrett S, additional, Ezzat, Allison M, additional, Girdwood, Michael, additional, Haberfield, Melissa, additional, Hughes, Mick, additional, Ingelsrud, Lina Holm, additional, Khan, Karim M, additional, Le, Christina Y, additional, Losciale, Justin M, additional, Lundberg, Matilde, additional, Miciak, Maxi, additional, Øiestad, Britt Elin, additional, Patterson, Brooke, additional, Räisänen, Anu M, additional, Skou, Søren T, additional, Thorlund, Jonas Bloch, additional, Toomey, Clodagh, additional, Truong, Linda K, additional, Meer, Belle L. van, additional, West, Thomas James, additional, Young, James Justin, additional, Lohmander, L Stefan, additional, Emery, Carolyn, additional, Risberg, May Arna, additional, van Middelkoop, Marienke, additional, Roos, Ewa M, additional, and Crossley, Kay M, additional

Published
2022
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29. Clinically Relevant Subgroups Among Athletes Who Have Ruptured Their Anterior Cruciate Ligaments: A Delaware‐OsloCohort Study

Author

Arhos, Elanna K., Pohlig, Ryan T., Di Stasi, Stephanie, Risberg, May Arna, Snyder‐Mackler, Lynn, and Silbernagel, Karin Grävare

Abstract

To identify subgroups of individuals with anterior cruciate ligament (ACL) injuries based on patient characteristics, self‐reported outcomes, and functional performance at baseline, and to associate subgroups with long‐term outcomes after ACL rupture. A total of 293 participants (45.7% male, mean ± SD age 26.2 ± 9.4 years, days from injury 58 ± 35) were enrolled after effusion, pain, and range of motion impairments were resolved and quadriceps strength was at least 70% of the uninvolved limb. Mixture modeling was used to uncover latent subgroups without a prior group classification using probabilistic assignment. Variables include demographics, functional testing, and self‐reported outcome measures. Radiographic evidence of osteoarthritis (OA; i.e., Kellgren/Lawrence grade of ≥1) in the involved knee at 5 years after injury was the primary outcome of interest. Chi‐square tests assessed differences in the presence of radiographic OA in the involved knee between subgroups at 5 years after ACL rupture. Secondary outcomes of interest included radiographic OA in the uninvolved knee, return to preinjury sport by 2 years, operative status, and clinical OA (classified using Luyten et al criteria) at 5 years. Four distinct subgroups exist after ACL rupture (younger good self‐report, younger poor self‐report, older poor self‐report, older good self‐report) with 30%, 31%, 47%, and 53%, respectively, having involved knee OA. The percentage of radiographic OA was not significantly different between the groups (P= 0.059). The prevalence of OA in all subgroups is highly concerning. These results suggest there are unique subgroupings of individuals that may guide treatment after ACL rupture and reconstruction by providing support for developing a patient‐centered approach.

Published
2023
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35. A Framework to Guide the Development of Health Care Professional Education and Training in Best Evidence Osteoarthritis Care

Author

Kobayashi, Sarah, primary, Allen, Kelli, additional, Bennell, Kim, additional, Bowden, Jocelyn L., additional, Briggs, Andrew M., additional, Burgess, Annette, additional, Hinman, Rana S., additional, Holden, Melanie, additional, Østerås, Nina, additional, Godaker Risberg, May Arna, additional, Sharma, Saurab, additional, van der Esch, Martin, additional, and Eyles, Jillian P., additional

Published
2022
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36. Association of Quadriceps Strength Symmetry and Surgical Status with Clinical Osteoarthritis 5 Years after Anterior Cruciate Ligament Rupture

Author

Arhos, Elanna K., Thoma, Louise M., Grindem, Hege, Logerstedt, David, Risberg, May Arna, and Snyder-Mackler, Lynn

Subjects
Adult, Male, Anterior Cruciate Ligament Reconstruction, Anterior Cruciate Ligament Injuries, Humans, Female, Muscle Strength, Prospective Studies, Osteoarthritis, Knee, Article, Follow-Up Studies, Quadriceps Muscle
Abstract

OBJECTIVE: The objective of this study was to examine the association of quadriceps strength symmetry and surgical status (ACL reconstruction or nonoperative management) with early clinical knee OA 5 years after ACL injury or reconstruction. METHODS: 204/300 athletes were analyzed 5 years after ACL injury or reconstruction (ACLR). Quadriceps strength was measured and reported as a limb symmetry index. We identified participants with early clinical knee OA using criteria that two of four Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales score ≤85% (Luyten et al. 2018). We calculated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression, adjusted for age, sex, meniscal injury, and BMI, to examine the associations between quadriceps strength and surgical status with clinical knee OA. RESULTS: 21% of participants met KOOS criteria for clinical knee OA (Luyten et al. 2018). For every 1% increase in quadriceps limb symmetry index, there was 4% lower odds of clinical OA (adjusted OR 0.96, 95% CI 0.93–0.99) at 5 years. Surgical status was not associated with clinical knee OA (adjusted OR 0.58, 95% CI 0.23, 1.50). CONCLUSIONS: More symmetrical quadriceps strength, but not surgical status, 5 years after ACL injury or reconstruction was associated with lower odds of clinical knee OA.

Published
2022

37. sj-pdf-1-ajs-10.1177_03635465221116313 – Supplemental material for Four Distinct 5-Year Trajectories of Knee Function Emerge in Patients Who Followed the Delaware-Oslo ACL Cohort Treatment Algorithm

Author

Pedersen, Marie, Grindem, Hege, Berg, Bjørnar, Engebretsen, Lars, Axe, Michael J., Snyder-Mackler, Lynn, and Risberg, May Arna

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-ajs-10.1177_03635465221116313 for Four Distinct 5-Year Trajectories of Knee Function Emerge in Patients Who Followed the Delaware-Oslo ACL Cohort Treatment Algorithm by Marie Pedersen, Hege Grindem, Bjørnar Berg, Lars Engebretsen, Michael J. Axe, Lynn Snyder-Mackler and May Arna Risberg in The American Journal of Sports Medicine

Published
2022
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39. 343 - RISK FACTORS FOR INCIDENT KNEE OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author

Duong, Vicky, Abdel-shaheed, Christina, Ferreira, Manuela L., Narayan, Sujita W., Venkatesha, Venkatesha, Hunter, David, Zhu, Jimmy, Atukorala, inoshi, Kobayashi, Sarah, Goh, Siew Li, Briggs, Andrew M., Cross, Marita, Espinosa-Morales, Rolando, Fu, Kai, Guillemin, Francis, Keefe, Francis, Lohmander, Stefan, March, Lyn, Milne, George, Mei, Yifang, Mobasheri, Ali, Namane, Mosedi, Peat, George, Risberg, May Arna, Sharma, Saurab, Sit, Regina Wing-Shan, Telles, Rosa Weiss, and Cooper, Cyrus

Published
2024
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40. Long-term effect of exercise therapy and patient education on impairments and activity limitations in people with hip osteoarthritis: secondary outcome analysis of a randomized clinical trial

Author

Svege, Ida, Fernandes, Linda, Nordsletten, Lars, Holm, Inger, and Risberg, May Arna

Subjects
Patient education -- Analysis, Osteoarthritis -- Patient outcomes -- Care and treatment -- Research, Exercise therapy -- Health aspects -- Research, Health
Abstract

Background. The effect of exercise on specific impairments and activity limitations in people with hip osteoarthritis (OA) is limited. Objective. The study objective was to evaluate the long-term effect of exercise therapy and patient education on range of motion (ROM), muscle strength, physical fitness, walking capacity, and pain during walking in people with hip OA. Design. This was a secondary outcome analysis of a randomized clinical trial. Setting. The setting was a university hospital. Participants. One hundred nine people with clinically and radiographically evident hip OA were randomly allocated to receive both exercise therapy and patient education (exercise group) or patient education only (control group). Intervention. All participants attended a patient education program consisting of 3 group meetings led by 2 physical therapists. Two other physical therapists were responsible for providing the exercise therapy program, consisting of 2 or 3 weekly sessions of strengthening, functional, and stretching exercises over 12 weeks. Both interventions were conducted at a sports medicine clinic. Measurements. Outcome measures included ROM, isokinetic muscle strength, predicted maximal oxygen consumption determined with the Astrand bicycle ergometer test, and distance and pain during the Six-Minute Walk Test (6MWT). Follow-up assessments were conducted 4, 10, and 29 months after enrollment by 5 physical therapists who were unaware of group allocations. Results. No significant group differences were found for ROM, muscle strength, predicted maximal oxygen consumption, or distance during the 6MWT over the follow-up period, but the exercise group had less pain during the 6MWT than the control group at 10 months (mean difference=--8.5 mm; 95% confidence interval = -16.1, -0.9) and 29 months (mean difference=-9-3 mm; 95% confidence interval = - 18.1, -0.6). Limitations. Limitations of the study were reduced statistical power and 53% rate of adherence to the exercise therapy program. Conclusions. The previously described effect of exercise on self-reported function was not reflected by beneficial results for ROM, muscle strength, physical fitness, and walking capacity, but exercise in addition to patient education resulted in less pain during walking in the long term., Osteoarthritis (OA) of the hip is present in 5% to 11% of the general adult population, and prevalence increases with age. (1-4) Pain, stiffness, and functional impairments are the major [...]

Published
2016
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45. What tests should be used to assess functional performance in youth and young adults following anterior cruciate ligament or meniscal injury? A systematic review of measurement properties for the OPTIKNEE consensus.

Author

Berg, Bjørnar, Urhausen, Anouk P., Øiestad, Britt Elin, Whittaker, Jackie L., Culvenor, Adam G., Roos, Ewa M., Crossley, Kay M., Juhl, Carsten B., and Risberg, May Arna

Abstract

Objectives: To critically appraise and summarise measurement properties of functional performance tests in individuals following anterior cruciate ligament (ACL) or meniscal injury.Design: Systematic review.Data Sources: Systematic searches were performed in Medline (Ovid), Embase (Ovid), CINAHL (EBSCO) and SPORTSDiscus (EBSCO) on 7 July 2021.Eligibility Criteria For Selecting Studies: Studies evaluating at least one measurement property of a functional performance test including individuals following an ACL tear or meniscal injury with a mean injury age of ≤30 years. The COnsensus-based Standards for the selection of health Measurement INstruments Risk of Bias checklist was used to assess methodological quality. A modified Grading of Recommendations Assessment, Development and Evaluation assessed evidence quality.Results: Thirty studies evaluating 26 functional performance tests following ACL injury were included. No studies were found in individuals with an isolated meniscal injury. Included studies evaluated reliability (n=5), measurement error (n=3), construct validity (n=26), structural validity (n=1) and responsiveness (n=1). The Single Leg Hop and Crossover Hop tests showed sufficient intrarater reliability (high and moderate quality evidence, respectively), construct validity (low-quality and moderate-quality evidence, respectively) and responsiveness (low-quality evidence).Conclusion: Frequently used functional performance tests for individuals with ACL or meniscal injury lack evidence supporting their measurement properties. The Single Leg Hop and Crossover Hop are currently the most promising tests following ACL injury. High-quality studies are required to facilitate stronger recommendations of performance-based outcomes following ACL or meniscal injury. [ABSTRACT FROM AUTHOR]

Published
2022
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