4 results on '"Rishi Deshmukh"'
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2. HARMONI at ELT: overview of the capabilities and expected performance of the ELT's first light, adaptive optics assisted integral field spectrograph
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Niranjan . Thatte, Dave Melotte, Benoit Neichel, David Le Mignant, Ian Bryson, Fraser Clarke, Vanessa Ferraro-Wood, Thierry Fusco, Oscar Gonzalez, Hermine Schnetler, Matthias Tecza, Sandi Wilson, Alonso Álvarez Urueña, Heribert A. Vilaseca, Santiago Arribas Mocoroa, Gonzalo José Carracedo Carballale, Alejandro Crespo, Alberto Estrada Piqueras, Miriam García García, Cecilia Martínez Martín, Miguel Pereira Santaella, Michele Perna, Javier Piqueras López, Niolas Bouché, Didier Boudon, Eric Daguisé, Karen Disseau, Jérémy J. Fensch, Adrien Girardot, Matthieu Guibert, Aurélien Jarno, Alexandre Jeanneau, Jens-Kristian Krogager, Florence Laurent, Magali Loupias, Jean-Emmanuel Migniau, Laure Piqueras, Alban Remillieux, Johan Richard, Arlette Pecontal, Lisa F. Bardou, David Barr, Sylvain Cetre, Rishi Deshmukh, Sofia Dimoudi, Marc Dubbledam, Andrew Dunn, Dimitra Gadotti, Joss J. Guy, David L. King, David J. Little, Anna McLeod, Simon Morris, Tim Morris, Kieran S. O'Brien, Emily Ronson, Russell Smith, Lazar Staykov, Mark Swinbank, Matthew Townson, Matteo Accardo, Domingo Alvarez Mendez, Elizabeth George, Joshua Hopgood, Derek Ives, Leander Mehrgan, Eric Mueller, Javier Reyes-Moreno, Ralf Conzelmann, Pablo Gutierrez Cheetham, Ángel Alonso-Sánchez, Giuseppina Battaglia, Miguel Angel Cagigas Garcia, Haresh M. Chulani, Graciela C. Delgado García, Patricia Fernández-Izquierdo, Ana Belén Fragoso López, Begoña García-Lorenzo, Alberto Hernández González, Elvio Hernández Suárez, Jose Miguel Herreros Linares, Enrique Joven, Roberto López López, Alejandro Antonio Lujan Gonzalez, Yolanda Martín, Evencio Mediavilla, Saúl Menéndez Mendoza, Luz Maria Montoya Martínez, José Peñate Castro, Álvaro Pérez, José Luis Rasilla, Rafael Rebolo-López, Luis Fernando Rodríguez-Ramos, Afrodisio Vega Moreno, Teodora Viera-Curbelo, Natacha Zanon Dametto, Alexis Carlotti, Jean-Jacques Correia, Stéphane Curaba, Alain Delboulbé, Sylvain Guieu, Adrien Hours, Zoltan Hubert, Laurent Jocou, Yves Magnard, Thibaut Moulin, Fabrice Pancher, Patrick Rabou, Eric Stadler, Maxime Vérove, Thierry Contini, Marie Larrieu, Olivier Boebion, Yan Fantéï-Caujolle, Daniel Lecron, Sylvain Rousseau, Philippe Amram, Olivier Beltramo-Martin, William Bon, Anne Bonnefoi, William Ceria, Zalpha Challita, Yannick Charles, Elodie Choquet, Carlos Correia, Anne Costille, Kjetil Dohlen, Franck Ducret, Kacem El Hadi, Jean-Luc Gach, Jean-Luc Gimenez, Olivier Groussin, Marc Jaquet, Pierre Jouve, Fabrice Madec, Felipe Pedreros Bustos, Edgard Renault, Patrice Sanchez, Arthur Vigan, Pascal Vola, Annie Zavago, Romain Fétick, Caroline Lim, Cyril Petit, Jean-Francois Sauvage, Nicolas Védrenne, Fehim Taha Bagci, Martin E. Caldwell, Ellis Elliott, Peter Hiscock, Emma Johnson, Murali Nalagatla, Aristea Seitis, Mark Wells, Martin Black, Charlotte Z. Bond, Saskia Brierley, Kenneth Campbell, Neil Campbell, James Carruthers, William Cochrane, Chris Evans, Joel Harman, William Humphreys, Thomas Louth, Chris Miller, David Montgomery, Meenu Murali, John Murray, Norman O'Malley, Ruben Sanchez-Janssen, Noah Schwartz, Patrick Smith, Jonathan Strachan, Stephen Todd, Stuart Watt, Martyn Wells, Asim Yaqoob, Eric Bell, Oleg O. Gnedin, Kayhan Gultekin, Mario Mateo, Michael Meyer, Munadi Ahmad, Jayne Birkby, Michael Booth, Michele Cappellari, Edgar Castillo Dominguez, Jorge Chao Ortiz, David Gooding, Kearn Grisdale, Andrea Hidalgo Valadez, Laurence Hogan, James Kariuki, Ian Lewis, Adam Lowe, Zeynep Ozer, Laurence Routledge, Dimitra Rigopoulou, Alec York, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay [Palaiseau], ONERA-Université Paris-Saclay, DOTA, ONERA, Université Paris Saclay [Châtillon], DOTA, ONERA [Salon], and ONERA
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ELT ,[PHYS]Physics [physics] ,[SPI]Engineering Sciences [physics] ,[SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO] ,OPTIQUE ADAPTATIVE ,[PHYS.ASTR.SR]Physics [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR] ,[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM] - Abstract
International audience; HARMONI is the first light, adaptive optics assisted, integral field spectrograph for the European Southern Observatory’s Extremely Large Telescope (ELT). A work-horse instrument, it provides the ELT’s diffraction limited spectroscopic capability across the near-infrared wavelength range. HARMONI will exploit the ELT’s unique combination of exquisite spatial resolution and enormous collecting area, enabling transformational science. The design of the instrument is being finalized, and the plans for assembly, integration and testing are being detailed. We present an overview of the instrument’s capabilities from a user perspective, and provide a summary of the instrument’s design. We also include recent changes to the project, both technical and programmatic, that have resulted from red-flag actions. Finally, we outline some of the simulated HARMONI observations currently being analyzed.
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- 2022
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3. The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy
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Hong Soon Kang, Anton M. Jetten, Kevin Gerrish, Amir Aghajanian, Ju Youn Beak, Brian C. Jensen, Seok Jae Hong, Wei Huang, Rishi Deshmukh, and Nishi Kadakia
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HIF-1α, hypoxia-inducible factor-1α ,Caveolin 3 ,PINK1, PTEN-induced putative kinase 1 ,LC3B-II, microtubule-associated protein light chain beta 3-II ,Mitochondrion ,Biochemistry ,CMKO, cardiomyocyte-specific RORα KO ,JC-1, 5, 5′, 6, 6′-tetrachloro-1, 1′, 3, 3′-tetraethylbenzimidazolylcarbocyanine iodide ,Mitochondria, Heart ,Mice ,Mitophagy ,OCR, oxygen consumption rate ,Myocytes, Cardiac ,Cav-3, caveolin-3 ,mt-Keima, mitochondrial-targeted Keima ,shCtrl, scrambled shRNA ,Cardioprotection ,Gene knockdown ,LDH, lactate dehydrogenase ,Bnip3, BCL2 interacting protein 3 ,HRP, horseradish peroxidase ,Nuclear Receptor Subfamily 1, Group F, Member 1 ,shRORα, shRNA against RORα ,Cell biology ,ChIP, chromatin immunoprecipitation ,BFA1, bafilomycin A1 ,SDH, succinate dehydrogenase ,NRVMs, neonatal rat ventricular myocytes ,qRT-PCR, quantitative RT-PCR ,Research Article ,caveolin-3 ,mPTP, mitochondrial permeability transition pore ,cardiomyocyte mitochondrial physiology ,Biology ,ROS, reactive oxygen species ,Downregulation and upregulation ,Animals ,TEM, transmission electron microscopy ,Molecular Biology ,ROR, retinoic acid–related orphan nuclear receptor ,Ang II, angiotensin II ,hypoxia ,Autophagy ,Cell Biology ,RAR-related orphan receptor alpha (ROR-alpha) ,Nuclear receptor ,Hsp60, heat shock protein 60 ,PFA, paraformaldehyde - Abstract
Preserving optimal mitochondrial function is critical in the heart, which is the most ATP-avid organ in the body. Recently, we showed that global deficiency of the nuclear receptor RORα in the "staggerer" mouse exacerbates angiotensin II-induced cardiac hypertrophy and compromises cardiomyocyte mitochondrial function. However, the mechanisms underlying these observations have not been defined previously. Here, we used pharmacological and genetic gain- and loss-of-function tools to demonstrate that RORα regulates cardiomyocyte mitophagy to preserve mitochondrial abundance and function. We found that cardiomyocyte mitochondria in staggerer mice with lack of functional RORα were less numerous and exhibited fewer mitophagy events than those in WT controls. The hearts of our novel cardiomyocyte-specific RORα KO mouse line demonstrated impaired contractile function, enhanced oxidative stress, increased apoptosis, and reduced autophagic flux relative to Cre(-) littermates. We found that cardiomyocyte mitochondria in "staggerer" mice with lack of functional RORα were upregulated by hypoxia, a classical inducer of mitophagy. The loss of RORα blunted mitophagy and broadly compromised mitochondrial function in normoxic and hypoxic conditions in vivo and in vitro. We also show that RORα is a direct transcriptional regulator of the mitophagy mediator caveolin-3 in cardiomyocytes and that enhanced expression of RORα increases caveolin-3 abundance and enhances mitophagy. Finally, knockdown of RORα impairs cardiomyocyte mitophagy, compromises mitochondrial function, and induces apoptosis, but these defects could be rescued by caveolin-3 overexpression. Collectively, these findings reveal a novel role for RORα in regulating mitophagy through caveolin-3 and expand our currently limited understanding of the mechanisms underlying RORα-mediated cardioprotection.
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- 2021
4. HARMONI: first light spectroscopy for the ELT: instrument final design and quantitative performance predictions
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Sofia Dimoudi, Jorge Chao Ortiz, Alexandre Jeanneau, Joel Vernet, Eric Daguisé, Adrien Hours, William Bon, Laurence Routledge, Ian Tosh, Eric Stadler, Ana Monreal, Kearn Grisdale, Ruben Sanchez-Janssen, Luis Fernando Rodriguez-Ramos, Jim Lynn, Alvaro Menduina, Angel Alonso Sanchez, Javier Piqueras López, Sylvain Guieu, Aurélien Jarno, Lazar Staykov, Teodora Viera, Joshua Hopgood, Chris Miller, David King, Vanessa Ferraro-Wood, Edgard Renault, Sandi Wilson, Matteo Accardo, James Carruthers, Alberto Estrada Piqueras, Matthieu Guibert, Cyril Petit, Angus Gallie, Zoltan Hubert, William Cochrane, Patricia Fernández Izquierdo, Kenny Campbell, Afrodisio Vega Moreno, Thierry Fusco, David Gooding, Patrice Sanchez, Madeline Close, Mark Swinbank, Jose Luis Rasilla, Arthur Vigan, Andrea Melissa Hidalgo, Romain Fétick, Miguel Pereira Santaella, Adam Lowe, Hermine Schnetler, Michael Meyer, E. Joven, Jean-Luc Gach, Yves Magnard, Josh Anderson, Benoit Neichel, Andy Born, José Peñate Castro, Simon L. Morris, José Linares, Kayhan Gültekin, Nicholas Bouché, Naomi Dobson, Chris Evans, John Capone, Jean-François Sauvage, Yolanda Martín Hernando, Miguel A. Cagigas, Jean-Emmanuel Migniau, Lynn Ritchie, Noah Schwartz, Didier Boudon, Ian Bryson, Alejandro Crespo, Neil Campbell, Jose Miguel Delgado, Alexis Carlotti, Johan Richard, Benoit Epinat, Matthew J. Townson, Stuart Watt, Charlotte Bond, Monica Valluri, Martin Black, Ellis Elliott, Pascal Vola, Elvio Hernandez Suarez, Miriam García García, Magali Loupias, Kacem El-Hadi, Fraser Clarke, John Murray, Matthias Tecza, Patrick Smith, Domingo Avarez Mendez, Leander Mehrgan, Nick Cann, Kjetil Dohlen, Frédéric Gonté, Karen Disseau, Lisa Bardou, Michael J. Booth, David Montgomery, Dave Melotte, Laurent Jocou, Nicola Vedrenne, Florence Laurent, Ana Belén. Fragoso López, Carlos Correia, Tom Louth, William Humphreys, Felipe Pedreros, David Henry, James Kariuki, David Le Mignant, Patrick Rabou, Elizabeth George, Olivier Beltramo-Martin, Sebastian Egner, Olivier Groussin, C. B. Lim, S. Rousseau, Myriam Rodrigues, Jean-Jacques Correia, Martyn Wells, Marc Llored, Thierry Contini, Ralf Conzelmann, Thibaut Moulin, Tea Seitis, Taha Bagci, Joel Le Merrer, Jeremy Blaizot, Oscar A. Gonzalez, Anne Bonnefoi, A. Remillieux, Diane Chapuis, Tim Morris, Derek Ives, Niranjan Thatte, Dimitra Rigopoulou, Roy Preece, Elodie Choquet, Laure Piqueras, Maria Begoña. Garcia-Lorenzo, Fabrice Pancher, Alain Delboulbe, Marie Larrieu, Battaglia Giuseppina, William Ceria, Mario Mateo, Michele Cappellari, Celine Peroux, Rishi Deshmukh, Arlette Pécontal-Rousset, Santiago Arribas, Roberto López, Joel Harman, Norman O'Malley, E. Mueller, Issa Jaafar, Zeynep Ozer, Kieran O'Brien, Anne Costille, Franck Ducret, Yan Fantei-Caujolle, Eddy Younger, Ian Lewis, Marc Dubbledam, Rafael Rebolo, Munadi Ahmad, Evencio Mediavilla, Daniel Lecron, DOTA, ONERA, Université Paris Saclay [Châtillon], and ONERA-Université Paris-Saclay
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[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph] ,Computer science ,Integration testing ,First light ,01 natural sciences ,010309 optics ,Integral field spectrograph ,0103 physical sciences ,Systems engineering ,Milestone (project management) ,Extremely Large Telescope ,Adaptive optics ,010303 astronomy & astrophysics ,ComputingMilieux_MISCELLANEOUS ,Design review - Abstract
HARMONI is the adaptive optics assisted, near-infrared and visible light integral field spectrograph for the Extremely Large Telescope (ELT). A first light instrument, it provides the work-horse spectroscopic capability for the ELT. As the project approaches its Final Design Review milestone, the design of the instrument is being finalized, and the plans for assembly, integration and testing are being detailed. We present an overview of the instrument's capabilities from a user perspective, provide a summary of the instrument's design, including plans for operations and calibrations, and provide a brief glimpse of the predicted performance for a specific observing scenario. The paper also provides some details of the consortium composition and its evolution since the project commenced in 2015.
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- 2020
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