1. The prognostic role of preoperative neutrophil-to-lymphocyte ratio in upper tract urothelial carcinoma
- Author
-
Rudra Prasad Ghorai, Brusabhanu Nayak, Ritesh Goel, Prashant Gupta, Rahul Raj, Seema Kaushal, Rishi Nayyar, Rajeev Kumar, and Amlesh Seth
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction: The blood-based inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), is a reliable prognostic biomarker for several cancers. Although the literature supports the correlation between preoperative NLR, clinicopathological characteristics, and oncological outcomes in upper tract urothelial carcinoma (UTUC), the cutoff of NLR is still debated. This study aimed to determine the prognostic value of NLR in patients with UTUC. Methods: This was a retrospective analysis of prospectively collected data from July 2012 to December 2022 evaluating patients with UTUC who underwent radical nephroureterectomy (RNU). NLR was calculated using the neutrophil and lymphocyte counts obtained a day before the surgery and the cutoff value was set as 2.5. Kaplan–Meier and Cox’s proportional hazards regression were used to analyze the association between NLR and the oncological outcomes. Results: The study included 91 patients (78 males, 13 females) in the final analysis with a median follow-up of 49 months (8–130). The mean age of the patients with NLR
- Published
- 2024
- Full Text
- View/download PDF