Search

Your search keyword '"Rivas, Agustina"' showing total 20 results
Start Over Author "Rivas, Agustina"
20 results on '"Rivas, Agustina"'

1. Feasibility of a screening algorithm for chronic thromboembolic pulmonary hypertension: The OSIRIS study

Author

Otero, Remedios, Lobo, José Luis, López, Raquel, Fernández, Carmen, Jiménez, David, Muriel, Alfonso, Alfonso, María, Ballaz, Aitor, Núñez-Ares, Ana, Rodríguez-Matute, Consolación, de Miguel-Díez, Javier, Rodríguez-Chiaradía, Diego Agustín, Alcalde, Mercedes, Elías, Teresa, Jara-Palomares, Luis, Rivas, Agustina, Alonso, Ángel, García-Ortega, Alberto, Sancho, Teresa, Morillo, Raquel, García-Bragado, Fernando, Hernández-Blasco, Luis, Uresandi, Fernando, Madridano, Olga, Agüero, Ramón, and Monreal, Manuel

Published
2023
Full Text
View/download PDF

4. Outcome of Patients with Venous Thromboembolism and Factor V Leiden or Prothrombin 20210 Carrier Mutations During the Course of Anticoagulation

Author

Decousus, Hervé, Prandoni, Paolo, Brenner, Benjamin, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Tzoran, Inna, Reis, Abilio, Bosevski, Marijan, Bounameaux, Henri, Malý, Radovan, Wells, Philip, Papadakis, Manolis, Adarraga, M.D., Aibar, M.A., Alfonso, M., Arcelus, J.I., Barba, R., Barrón, M., Barrón-Andrés, B., Bascuñana, J., Blanco-Molina, A., Bueso, T., Cañada, G., Cañas, I., Chic, N., del Pozo, R., del Toro, J., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Falgá, C., Fernández-Capitán, C., Fidalgo, M.A., Font, C., Font, L., Gallego, P., García, A., García, M.A., García-Bragado, F., García-Brotons, P., Gavín, O., Gómez, C., Gómez, V., González, J., González-Marcano, D., Grau, E., Grimón, A., Guijarro, R., Gutiérrez, J., Hernández-Comes, G., Hernández-Blasco, L., Hermosa-Los Arcos, M.J., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Joya, M.D., Llamas, P., Lecumberri, R., Lobo, J.L., López, P., López-Jiménez, L., López-Reyes, R., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Maestre, A., Marchena, P.J., Martín-Martos, F., Monreal, M., Nieto, J.A., Nieto, S., Núñez, A., Núñez, M.J., Odriozola, M., Otero, R., Pedrajas, J.M., Pérez, G., Pérez-Ductor, C., Peris, M.L., Porras, J.A., Reig, O., Riera-Mestre, A., Riesco, D., Rivas, A., Rodríguez, C., Rodríguez-Dávila, M.A., Rosa, V., Ruiz-Giménez, N., Sahuquillo, J.C., Sala-Sainz, M.C., Sampériz, A., Sánchez-Martínez, R., Sánchez Simón-Talero, R., Sanz, O., Soler, S., Suriñach, J.M., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Valero, B., Valle, R., Vela, J., Vicente, M.P., Villalobos, A., Vanassche, T., Verhamme, P., Wells, P., Hirmerova, J., Malý, R., Tomko, T., del Pozo, G., Salgado, E., Sánchez, G.T., Bertoletti, L., Bura-Riviere, A., Mahé, I., Merah, A., Moustafa, F., Papadakis, M., Braester, A., Brenner, B., Tzoran, I., Antonucci, G., Barillari, G., Bilora, F., Bortoluzzi, C., Cattabiani, C., Ciammaichella, M., Di Biase, J., Di Micco, P., Duce, R., Ferrazzi, P., Giorgi-Pierfranceschi, M., Grandone, E., Imbalzano, E., Lodigiani, C., Maida, R., Mastroiacovo, D., Pace, F., Pesavento, R., Pinelli, M., Poggio, R., Prandoni, P., Rota, L., Tiraferri, E., Tonello, D., Tufano, A., Visonà, A., Zalunardo, B., Gibietis, V., Skride, A., Vitola, B., Monteiro, P., Ribeiro, J.L., Sousa, M.S., Bosevski, M., Zdraveska, M., Bounameaux, H., Calanca, L., Erdmann, A., Mazzolai, L., Fidalgo, Ángeles, Rivas, Agustina, Wells, Philip S., Gavín, Olga, Adarraga, María Dolores, Moustafa, Farès, and Monreal, Manuel

Published
2017
Full Text
View/download PDF

5. Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Author

Bikdeli, Behnood, primary, Jiménez, David, additional, del Toro, Jorge, additional, Piazza, Gregory, additional, Rivas, Agustina, additional, Fernández‐Reyes, José Luis, additional, Sampériz, Ángel, additional, Otero, Remedios, additional, Suriñach, José María, additional, Siniscalchi, Carmine, additional, Martín‐Guerra, Javier Miguel, additional, Castro, Joaquín, additional, Muriel, Alfonso, additional, Lip, Gregory Y. H., additional, Goldhaber, Samuel Z., additional, Monreal, Manuel, additional, Prandoni, Paolo, additional, Brenner, Benjamin, additional, Farge‐Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Schellong, Sebastian, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, María Dolores, additional, Agud, María, additional, Aibar, Jesús, additional, Aibar, Miguel Ángel, additional, Amado, Cristina, additional, Arcelus, Juan Ignacio, additional, Baeza, Carlos, additional, Ballaz, Aitor, additional, Barbagelata, Cristina, additional, Barrón, Manuel, additional, Barrón‐Andrés, Belén, additional, Blanco‐Molina, Ángeles, additional, Botella, Ernesto, additional, Camon, Ana María, additional, Cañas, Inmaculada, additional, Casado, Ignacio, additional, Chasco, Leyre, additional, Criado, Juan, additional, de Ancos, Cristina, additional, de Miguel, Javier, additional, Demelo‐Rodríguez, Pablo, additional, Díaz‐Peromingo, José Antonio, additional, Di Campli, Mario Virgilio, additional, Díez‐Sierra, Javier, additional, Domínguez, Irene Milagros, additional, Escribano, José Carlos, additional, Falgá, Conxita, additional, Farfán‐Sedano, Ana Isabel, additional, Fernández‐Capitán, Carmen, additional, Fernández‐Reyes, Jose Luis, additional, Fidalgo, María Ángeles, additional, Flores, Katia, additional, Font, Carme, additional, Font, Llorenç, additional, Francisco, Iria, additional, Gabara, Cristina, additional, Galeano‐Valle, Francisco, additional, Galindo, David, additional, García, María Angelina, additional, García‐Bragado, Ferrán, additional, García de Herreros, Marta, additional, García‐Hernáez, Raquel, additional, García‐Mullor, María Mar, additional, García‐Raso, Arantxa, additional, Gavín‐Sebastián, Olga, additional, Gil‐Díaz, Aida, additional, Gómez‐Cuervo, Covadonga, additional, Grau, Enric, additional, Guirado, Leticia, additional, Gutiérrez, Javier, additional, Hernández‐Blasco, Luis, additional, Hernando, Elena, additional, Herreros, Miguel, additional, Jara‐Palomares, Luis, additional, Jaras, María Jesús, additional, Jiménez, Rafael, additional, Joya, Maria Dolores, additional, León, José Manuel, additional, Lima, Jorge, additional, Llamas, Pilar, additional, Lobo, José Luis, additional, López‐Jiménez, Luciano, additional, López‐Miguel, Patricia, additional, López‐Núñez, Juan José, additional, López‐Reyes, Raquel, additional, López‐Ruiz, Antonio, additional, López‐Sáez, Juan Bosco, additional, Lorenzo, Alicia, additional, Madridano, Olga, additional, Maestre, Ana, additional, Marchena, Pablo Javier, additional, Martín del Pozo, Mar, additional, Martín‐Martos, Francisco, additional, Mella, Carmen, additional, Mellado, Meritxell, additional, Mercado, Maria Isabel, additional, Moisés, Jorge, additional, del Valle Morales, María, additional, Muñoz‐Blanco, Arturo, additional, Muñoz‐Rivas, Nuria, additional, Navas, María Sierra, additional, Nieto, Jose Antonio, additional, Núñez‐Fernández, Manuel Jesús, additional, Obispo, Berta, additional, Olid, Mónica, additional, Olivares, María Carmen, additional, Orcastegui, José Luis, additional, Ortega‐Michel, Clara, additional, Osorio, Jeisson, additional, Otalora, Sonia, additional, Parra, Pedro, additional, Parra, Virginia, additional, Pedrajas, José María, additional, Pellejero, Galadriel, additional, Porras, José Antonio, additional, Portillo, José, additional, Riera‐Mestre, Antoni, additional, Rivera‐Civico, Francisco, additional, Rodríguez‐Chiaradía, Diego Agustín, additional, Rodríguez‐Cobo, Ana, additional, Rodríguez‐Matute, Consolación, additional, Rogado, Jacobo, additional, Roig, Sonia, additional, Rosa, Vladimir, additional, Ruiz‐Artacho, Pedro, additional, Ruiz‐Giménez, Nuria, additional, Ruiz‐Ruiz, Justo, additional, Ruiz‐Sada, Pablo, additional, Salgueiro, Giorgina, additional, Sánchez‐Martínez, Rosario, additional, Sánchez‐Muñoz‐Torrero, Juan Francisco, additional, Sancho, Teresa, additional, Sirisi, Merçe, additional, Soler, Silvia, additional, Tirado, Raimundo, additional, Torres, María Isabel, additional, Tolosa, Carles, additional, Trujillo‐Santos, Javier, additional, Uresandi, Fernando, additional, Valero, Beatriz, additional, Valle, Reina, additional, Vela, Jerónimo Ramón, additional, Vidal, Gemma, additional, Villares, Paula, additional, Zamora, Carles, additional, Gutiérrez, Paula, additional, Vázquez, Fernando Javier, additional, Engelen, Matthias, additional, Vanassche, Thomas, additional, Hirmerova, Jana, additional, Salgado, Estuardo, additional, Ait Abdallah, Nassim, additional, Bura‐Riviere, Alessandra, additional, Crichi, Benjamin, additional, Debourdeau, Philippe, additional, Olivier, Espitia, additional, Falvo, Nicolas, additional, Galliazzo, Silvia, additional, Helfer, Hélène, additional, Mahé, Isabelle, additional, Moustafa, Farès, additional, Poenou, Geraldine, additional, Braester, Andrei, additional, Bilora, Franca, additional, Bucherini, Eugenio, additional, Ciammaichella, Maurizio, additional, Imbalzano, Egidio, additional, Maida, Rosa, additional, Mastroiacovo, Daniela, additional, Pace, Federica, additional, Pesavento, Raffaele, additional, Pomero, Fulvio, additional, Quintavalla, Roberto, additional, Rocci, Anna, additional, Romualdi, Roberta, additional, Tufano, Antonella, additional, Visonà, Adriana, additional, Zalunardo, Beniamino, additional, Gibietis, Valdis, additional, Kigitovica, Dana, additional, Skride, Andris, additional, Fonseca, Samuel, additional, Martins, Filipa, additional, Meireles, Jose, additional, Mazzolai, Lucia, additional, Bikdeli, Behnood, additional, Tafur, Alfonso J., additional, Ochoa‐Chaar, Cassius Iyad, additional, Weinberg, Ido, additional, and Wilkins, Hannah, additional

Published
2021
Full Text
View/download PDF

7. Association between preexisting versus newly identified atrial fibrillation and outcomes of patients with acute pulmonary embolism

Author

Bikdeli, Behnood, Jiménez, David, Toro, Jorge del, Piazza, Gregory, Rivas, Agustina, Fernández-Reyes, José Luis, Otero Candelera, Remedios, Monreal, Manuel, Universidad de Sevilla. Departamento de Medicina, and Sanofi Spain

Subjects
Pulmonary embolism, Mortality, Atrial fibrillation, Outcome
Abstract

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.

Published
2021

8. Prediction of early mortality in patients with cancer-associated thrombosis in the rIete Database

Author

Fuentes, Harry E., Tafur, Alfonso J., Caprini, Joseph A., Alatri, Adriano, Trujillo-santos, Javier, Farge-bancel, Dominique, Rosa, Vladimir, Font, Llorenc, Vilaseca, Alicia, Monreal, Manuel, Adarraga, Maria D., Aibar, Miguel A., Aibar, Jesus, Amado, Cristina, Aranda, Carlos, Arcelus Juan, I, Ballaz, Aitor, Barba, Raquel, Barillari, Giovanni, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Benzidia, Ilham, Bertoletti, Laurent, Blanco-Molina, Angeles, Bilora, Franca, Bortoluzzi, Cristiano, Bosevski, Marijan, Bounameaux, Henri, Braester, Andrei, Brandolin, Barbara, Brenner, Benjamin, Bucherini, Eugenio, Hanh My Bui, Bura-Riviere, Alessandra, Camon, Ana M., Carrasco, Cristina, Castro, Joaquin, Cesta, Alisia, Ciammaichella, Maurizio, Cruz, Javier A., de Ancos, Cristina, del Toro, Jorge, Demelo, Pablo, Dentali, Francesco, del Carmen Diaz-pedroche, Maria, Diaz-Peromingo, Jose A., Di Micco, Pierpaolo, Di Pangrazio, Marco, Ellis, Martin, Encabo, Marta, Falga, Conxita, Falvo, Nicolas, Farfan Ana, Fernandez-Capitan, Carmen, Angeles Fidalgo, Maria, Font, Carme, Fresa, Marco, Furest, Ildefonso, Garcia, Maria A., Garcia-Braoado, Ferran, Garcia-Morillo, Marcia, Garcia-Raso, Aranzazu, Gavin, Olga, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grandone, Elvira, Grau, Enric, Guijarro, Ricardo, Gutierrez, Javier, Gutierrez, Paula, Hernandez-Blasco, Luis, Hu, Adrian, Hirmerova, Jana, Imbalzano, Egidio, Jara-Palomares, Luis, Jaras, Maria J., Jimenez, David, Jou, Ines, Joya, Maria D., Krstevski, Gorjan, Lessiani, Gianfranco, Lima, Jorge, Llamas, Pilar, Lobo, Jose L., Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Lopez-Nunez, Juan J., Lopez-Reyes, Raquel, Lopez-Saez, Juan B., Lorente, Manuel A., Lorenzo, Alicia, Loring, Monica, Lumbierres, Marina, Mahe, Isabelle, Maida, Rosa, Maly, Radovan, Manrique-Abos, Isabel, Marchena, Pablo J., Martin-Fernandez, Miguel, Martin-Guerra, Javier M., Martin-Romero, Miguel, Mastroiacovo, Danicla, Mazzolai, Lucia, Mellado, Meritxell, Merah, Adel, del Valle Morales, Maria, Moustafa, Fares, Ney, Barbara, Nieto, Jose A., Nunez, Manuel J., del Carmen Olivares, Maria, Otalora, Sonia, Otero, Remedios, Pace, Federica, Parisi, Roberto, Pedrajas, Jose Maria, Pellejero, Galadriel, Perez-Ductor, Cristina, Perez-Jacoiste, Asuncion, Perez-Rus, Gloria, Peris, Maria L., Pesavento, Raffaele, Pesce, Maria L., Porras, Jose A., Prandoni, Paolo, Quinta-Valla, Roberto, Riesco, David, Rivas, Agustina, Rocci, Anna, Rodriguez-Davila, Maria A., Rodriguez-Hernandez, Adela, Rubio, Carmen M., Ruiz-Alcaraz, Sandra, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Ruiz-Torregrosa, Paloma, Sahuquillo, Joan C., Sala-Sainz, Carmen, Salgado, Estuardo, Samperiz, Angel, Sanchez-Munoz-Torrero, Juan F., Sancho, Teresa, Sanoja, Indra D., Siniscalchi, Carmine, Skride, Andris, Soler, Silvia, Sotgiu, Pietro, Soto, Maria J., Surinach, Jose M., Tiraferri, Eros, Tonello, Diego, Torres Maria, Tufano, Antonella, Tzoran, Inns, Uresandi, Fernando, Usandizaga, Esther, Valle, Reins, Vanassche, Thomas, Vandenbriele, Christophe, Vazquez, Fernando J., Verhamme, Peter, Villalobos, Aurora, Visona, Adriana, Ngoc Vo Hong, Yoo, Hugo H., Zdraveska, Marija, Fuentes, Harry E., Tafur, Alfonso J., Caprini, Joseph A., Alatri, Adriano, Trujillo-santos, Javier, Farge-bancel, Dominique, Rosa, Vladimir, Font, Llorenc, Vilaseca, Alicia, Monreal, Manuel, Adarraga, Maria D., Aibar, Miguel A., Aibar, Jesu, Amado, Cristina, Aranda, Carlo, Arcelus, Juan, I, Ballaz, Aitor, Barba, Raquel, Barillari, Giovanni, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Benzidia, Ilham, Bertoletti, Laurent, Blanco-Molina, Angele, Bilora, Franca, Bortoluzzi, Cristiano, Bosevski, Marijan, Bounameaux, Henri, Braester, Andrei, Brandolin, Barbara, Brenner, Benjamin, Bucherini, Eugenio, Hanh My, Bui, Bura-Riviere, Alessandra, Camon, Ana M., Carrasco, Cristina, Castro, Joaquin, Cesta, Alisia, Ciammaichella, Maurizio, Cruz, Javier A., de Ancos, Cristina, del Toro, Jorge, Demelo, Pablo, Dentali, Francesco, del Carmen Diaz-pedroche, Maria, Diaz-Peromingo, Jose A., Di Micco, Pierpaolo, Di Pangrazio, Marco, Ellis, Martin, Encabo, Marta, Falga, Conxita, Falvo, Nicola, Farfan, Ana, Fernandez-Capitan, Carmen, Angeles Fidalgo, Maria, Font, Carme, Fresa, Marco, Furest, Ildefonso, Garcia, Maria A., Garcia-Braoado, Ferran, Garcia-Morillo, Marcia, Garcia-Raso, Aranzazu, Gavin, Olga, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grandone, Elvira, Grau, Enric, Guijarro, Ricardo, Gutierrez, Javier, Gutierrez, Paula, Hernandez-Blasco, Lui, Hu, Adrian, Hirmerova, Jana, Imbalzano, Egidio, Jara-Palomares, Lui, Jaras, Maria J., Jimenez, David, Jou, Ine, Joya, Maria D., Krstevski, Gorjan, Lessiani, Gianfranco, Lima, Jorge, Llamas, Pilar, Lobo, Jose L., Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Lopez-Nunez, Juan J., Lopez-Reyes, Raquel, Lopez-Saez, Juan B., Lorente, Manuel A., Lorenzo, Alicia, Loring, Monica, Lumbierres, Marina, Mahe, Isabelle, Maida, Rosa, Maly, Radovan, Manrique-Abos, Isabel, Marchena, Pablo J., Martin-Fernandez, Miguel, Martin-Guerra, Javier M., Martin-Romero, Miguel, Mastroiacovo, Danicla, Mazzolai, Lucia, Mellado, Meritxell, Merah, Adel, del Valle Morales, Maria, Moustafa, Fare, Ney, Barbara, Nieto, Jose A., Nunez, Manuel J., del Carmen Olivares, Maria, Otalora, Sonia, Otero, Remedio, Pace, Federica, Parisi, Roberto, Pedrajas, Jose Maria, Pellejero, Galadriel, Perez-Ductor, Cristina, Perez-Jacoiste, Asuncion, Perez-Rus, Gloria, Peris, Maria L., Pesavento, Raffaele, Pesce, Maria L., Porras, Jose A., Prandoni, Paolo, Quinta-Valla, Roberto, Riesco, David, Rivas, Agustina, Rocci, Anna, Rodriguez-Davila, Maria A., Rodriguez-Hernandez, Adela, Rubio, Carmen M., Ruiz-Alcaraz, Sandra, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Ruiz-Torregrosa, Paloma, Sahuquillo, Joan C., Sala-Sainz, Carmen, Salgado, Estuardo, Samperiz, Angel, Sanchez-Munoz-Torrero, Juan F., Sancho, Teresa, Sanoja, Indra D., Siniscalchi, Carmine, Skride, Andri, Soler, Silvia, Sotgiu, Pietro, Soto, Maria J., Surinach, Jose M., Tiraferri, Ero, Tonello, Diego, Torres, Maria, Tufano, Antonella, Tzoran, Inn, Uresandi, Fernando, Usandizaga, Esther, Valle, Rein, Vanassche, Thoma, Vandenbriele, Christophe, Vazquez, Fernando J., Verhamme, Peter, Villalobos, Aurora, Visona, Adriana, Ngoc Vo, Hong, Yoo, Hugo H., and Zdraveska, Marija

Subjects
Adult, Male, Internationality, Adolescent, Population, 030204 cardiovascular system & hematology, 030230 surgery, computer.software_genre, Logistic regression, Risk Assessment, Cohort Studies, Young Adult, 03 medical and health sciences, Mortality, Neoplasms, Premature, Thrombosis, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Humans, Medicine, Registries, Child, education, Aged, education.field_of_study, Framingham Risk Score, Database, business.industry, Infant, Newborn, Infant, Venous Thromboembolism, Odds ratio, Middle Aged, medicine.disease, Pulmonary embolism, Logistic Models, Child, Preschool, Predictive value of tests, Multivariate Analysis, Female, Cardiology and Cardiovascular Medicine, Risk assessment, business, computer, Cohort study
Abstract

BACKGROUND: Proper risk stratification of patients for early mortality after cancer-associated thrombosis may lead to personalized anticoagulation protocols. Therefore, we aimed to derive and validate a scoring system to predict early mortality in this population. To this end, we selected patients with active cancer and thrombosis from the Computerized Registry of Patients with Venous Thromboembolism database. METHODS: The main outcome was all cause mortality within the month following a thrombotic event. We used a simple random selection to split are data in a derivation and a validation cohort. In the derivation cohort, we used recursive partitioning and binary logistic regression to identify groups at risk and to determine the likelihood of the primary outcome. The risk score was developed based on odds ratios from the final multivariate model, and then tested in the validation cohort. RESULTS: In 10,025 eligible patients, we identified 6 predictors of 30-day mortality: leukocytosis =11.5x109/L; platelet count =160x109/L, metastasis, recent immobility, initial presentation as pulmonary embolism and Body Mass Index

Published
2019

9. Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

Author

Jara-Palomares, Luis, Alfonso, Maria, Maestre, Ana, Jimenez, David, Garcia-Bragado, Fernando, Font, Carme, Lopez Reyes, Raquel, Hernandez Blasco, Luis, Vidal, Gemma, Otero, Remedios, Monreal, Manuel, Adarraga, Ma Dolores, Angel Aibar, Miguel, Aibar, Jesus, Amado, Cristina, Ignacio Arcelus, Juan, Ballaz, Aitor, Barba, Raquel, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Blanco-Molina, Angeles, Maria Camon, Ana, Canas, Inmaculada, Carrasco, Cristina, Castro, Joaquin, de Ancos, Cristina, Del Toro, Jorge, Demelo, Pablo, Antonio Diaz-Peromingo, Jose, Diaz-Simon, Raquel, Falga, Conxita, Isabel Farfan, Ana, Fernandez-Capitan, Carmen, Del Carmen Fernandez-Criado, Maria, Fernandez-Nunez, Sandra, Fidalgo, Angeles, Font, Llorenc, Angelina Garcia, Maria, Garcia-Morillo, Marcial, Garcia-Raso, Aranzzu, Gavin-Sebastian, Olga, del Carmen Gayol, Maria, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grau, Enric, Gutierrez, Javier, Gutierrez-Gonzalez, Sara, Iglesias, Marina, Jaras, Ma Jesus, Jou, Ines, Dolores Joya, Maria, Lalueza, Antonio, Lima, Jorge, Llamas, Pilar, Luis Lobo, Jose, Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Jose Lopez-Nunez, Juan, Bosco Lopez-Saez, Juan, Alejandro Lorente, Manuel, Lorenzo, Alicia, Loring, Monica, Madridano, Olga, Javier Marchena, Pablo, Miguel Martin, Javier, Mellado, Meritxell, del Valle Morales, Ma, Luisa Nieto, Maria, Antonio Nieto, Jose, Jesus Nunez, Manuel, Carmen Olivares, Maria, Maria Pedrajas, Jose, Pellejero, Galadriel, Prez-Rus, Gloria, Peris, Ma Luisa, Antonio Porras, Jose, Rivas, Agustina, Angeles Rodriguez-Davila, Ma, Adela Rodriguez-Hernandez, A, Rubio, Carmen Ma, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Carles Sahuquillo, Joan, Salazar, Vladimir, Samperiz, Angel, Sanchez Munoz-Torrero, Juan Francisco, Sancho, Teresa, Soler, Silvia, Maria Surinach, Jose, Tapia, Elena, Tolosa, Caries, Isabel Torres, Maria, Trujillo-Santos, Javier, Uresandi, Fernando, Valle, Reina, Villares, Paula, Gutierrez, Paula, Javier Vazquez, Fernando, Vilaseca, Alicia, Vanassche, Thomas, Vandenbriele, Christophe, Verhamme, Peter, Hirmerova, Jana, Maly, Radovan, Celis, Gregory, del Pozo, Gustavo, Salgado, Estuardo, Benzidia, Ilham, Bertoletti, Laurent, Bura-Riviere, Alessandra, Debourdeau, Philippe, Farge-Bancel, Dominique, Hij, Adrian, Mahe, Isabelle, Moustafa, Fares, Schellong, Sebastian, Braester, Andrei, Brenner, Benjamin, Tzoran, Inna, Sharif-Kashani, Babak, Barillari, Giovanni, Bilora, Franca, Bortoluzzi, Cristiano, Brandolin, Barbara, Bucherini, Eugenio, Ciammaichella, Maurizio, Dentali, Francesco, Di Micco, Pierpaolo, Maida, Rosa, Mastroiacovo, Daniela, Mumoli, Nicola, Pace, Federica, Parisi, Roberto, Pesavento, Raffaelle, Prandoni, Paolo, Quintavalla, Roberto, Rocci, Anna, Romualdi, Roberta, Sinicalchi, Carmine, Tufano, Antonella, Visona, Adriana, Hong, Ngoc Vo, Zalunardo, Beniamino, Gibietis, Valdis, Kigitovica, Dana, Skride, Andris, Bosevski, Marijan, Bounameaux, Henri, Mazzolai, Lucia, Caprini, Joseph A, Hanh, My Bui, Khanh, Quoc Pham, Reis, Abilio, UCH. Departamento de Medicina (Extinguido), Producción Científica UCH 2019, UCH. Departamento de Medicina y Cirugía, Sanofi España, Bayer, Sociedad Española de Neumología y Cirugía Torácica, Jara-Palomares, L., Alfonso, M., Maestre, A., Jimenez, D., Garcia-Bragado, F., Font, C., Reyes, R. L., Blasco, L. H., Vidal, G., Otero, R., Monreal, M., Adarraga, M. ªD., Aibar, M. A., Aibar, J., Amado, C., Arcelus, J. I., Ballaz, A., Barba, R., Barron, M., Barron-Andres, B., Bascunana, J., Blanco-Molina, A., Camon, A. M., Canas, I., Carrasco, C., Castro, J., de Ancos, C., Del Toro, J., Demelo, P., Diaz-Peromingo, J. A., Diaz-Simon, R., Falga, C., Farfan, A. I., Fernandez-Capitan, C., del Carmen Fernandez-Criado, M., Fernandez-Nunez, S., Fidalgo, A., Font, L., Garcia, M. A., Garcia-Morillo, M., Garcia-Raso, A., Gavin-Sebastian, O., del Carmen Gayol, M., Gil-Diaz, A., Gomez, V., Gomez-Cuervo, C., Gonzalez-Martinez, J., Grau, E., Gutierrez, J., Gutierrez-Gonzalez, S., Iglesias, M., Jaras, M. ªJ., Jou, I., Joya, M. D., Lalueza, A., Lima, J., Llamas, P., Lobo, J. L., Lopez-Jimenez, L., Lopez-Miguel, P., Lopez-Nunez, J. J., Lopez-Saez, J. B., Lorente, M. A., Lorenzo, A., Loring, M., Madridano, O., Marchena, P. J., Martin, J. M., Mellado, M., Morales, M. ªV., Nieto, M. L., Nieto, J. A., Nunez, M. J., Olivares, M. C., Pedrajas, J. M., Pellejero, G., Perez-Rus, G., Peris, M. ªL., Porras, J. A., Rivas, A., Rodriguez-Davila, M. ªA., Adela Rodriguez-Hernandez, A., Rubio, C. M., Ruiz-Artacho, P., Ruiz-Ruiz, J., Ruiz-Sada, P., Sahuquillo, J. C., Salazar, V., Samperiz, A., Munoz-Torrero, J. F. S., Sancho, T., Soler, S., Surinach, J. M., Tapia, E., Tolosa, C., Torres, M. I., Trujillo-Santos, J., Uresandi, F., Valle, R., Villares, P., Gutierrez, P., Vazquez, F. J., Vilaseca, A., Vanassche, T., Vandenbriele, C., Verhamme, P., Hirmerova, J., Maly, R., Celis, G., del Pozo, G., Salgado, E., Benzidia, I., Bertoletti, L., Bura-Riviere, A., Debourdeau, P., Farge-Bancel, D., Hij, A., Mahe, I., Moustafa, F., Schellong, S., Braester, A., Brenner, B., Tzoran, I., Sharif-Kashani, B., Barillari, G., Bilora, F., Bortoluzzi, C., Brandolin, B., Bucherini, E., Ciammaichella, M., Dentali, F., Di Micco, P., Maida, R., Mastroiacovo, D., Mumoli, N., Pace, F., Parisi, R., Pesavento, R., Prandoni, P., Quintavalla, R., Rocci, A., Romualdi, R., Sinicalchi, C., Tufano, A., Visona, A., Hong, N. V., Zalunardo, B., Gibietis, V., Kigitovica, D., Skride, A., Bosevski, M., Bounameaux, H., Mazzolai, L., Caprini, J. A., Bui, H. M., Pham, K. Q., and Reis, A.

Subjects
PREDICTION, Embolism, Aparato circulatorio - Enfermedades - Pronóstico, Cardiovascular system - Diseases - Prognosis, lcsh:Medicine, 030204 cardiovascular system & hematology, 0302 clinical medicine, Retrospective Studie, Risk Factors, 030212 general & internal medicine, lcsh:Science, INDEX, education.field_of_study, Multidisciplinary, Middle Aged, Prognosis, Predictive value, Pulmonary embolism, Multidisciplinary Sciences, DERIVATION, Science & Technology - Other Topics, Major bleeding, Human, medicine.medical_specialty, ANTITHROMBOTIC THERAPY, Disease-free survival, Prognosi, Population, DIAGNOSIS, VALIDATION, Article, 03 medical and health sciences, STRATIFICATION, Thromboembolism, Internal medicine, medicine, Humans, In patient, education, Retrospective Studies, OLDER, VENOUS THROMBOEMBOLISM, Science & Technology, business.industry, Risk Factor, lcsh:R, CLINICAL PRESENTATION, Retrospective cohort study, medicine.disease, Embolia pulmonar - Pronóstico, Shock index, Pulmonary embolism - Prognosis, Spain, lcsh:Q, business, Pulmonary Embolism
Abstract

The RIETE investigators., In young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm, PREP, shock index and RIETE) in patients aged, This study received funding: SEPAR (1/2016) grupo GeCIR. We express our gratitude to Sanofi Spain for supporting this Registry with an unrestricted educational grant. We also wish to thank Bayer Pharma AG for supporting this Registry. Bayer Pharma AG’s support was limited to the part of RIETE outside Spain, which accounts for a 25.20% of the total patients included in the RIETE Registry.

Published
2019

10. Patient-Level, Institutional, and Temporal Variations in Use of Imaging Modalities to Confirm Pulmonary Embolism

Author

Mehdipoor, Ghazaleh, primary, Jimenez, David, additional, Bertoletti, Laurent, additional, Fidalgo, Ángeles, additional, Sanchez Muñoz-Torrero, Juan Francisco, additional, Gonzalez-Martinez, José Pedro, additional, Blanco-Molina, Ángeles, additional, Ángel Aibar, Miguel, additional, Bonnefoy, Pierre-Benoît, additional, Khorasani, Ramin, additional, Prince, Martin R., additional, Bikdeli, Behnood, additional, Monreal, Manuel, additional, Adarraga, María Dolores, additional, Agud, María, additional, Azcarate-Agüero, Pedro, additional, Aibar, Jesús, additional, Alfonso, Joaquín, additional, Amado, Cristina, additional, Ignacio Arcelus, Juan, additional, Ballaz, Aitor, additional, Barba, Raquel, additional, Barrón, Cristina Barbagelata, Manuel, additional, Barrón-Andrés, Belén, additional, Camon, Ana María, additional, Cañas, Inmaculada, additional, Criado, Juan, additional, Ancos, Cristina de, additional, Miguel, Javier de, additional, del Toro, Jorge, additional, Demelo-Rodríguez, Pablo, additional, Díaz-Pedroche, Carmen, additional, Díaz-Peromingo, José Antonio, additional, Díaz-Simón, Raquel, additional, Díez-Sierra, Javier, additional, Milagros Domínguez, Irene, additional, Escribano, José Carlos, additional, Farfán, Ana Isabel, additional, Fernández-Capitán, Carmen, additional, Fernández-Reyes, José Luis, additional, Flores, Katia, additional, Font, Carme, additional, Font, Llorenç, additional, Francisco, Iria, additional, Gabara, Cristina, additional, Galeano-Valle, Francisco, additional, Ángeles García, María, additional, García-Bragado, Ferran, additional, García-García, María, additional, García-Raso, Aránzazu, additional, Gavín-Blanco, Olga, additional, Gavín-Sebastián, Olga, additional, Carmen Gayol, María, additional, Gil-Díaz, Aída, additional, Gómez-Cuervo, Covadonga, additional, Grau, Enric, additional, Gutiérrez-Guisado, Javier, additional, Hernández-Blasco, Luis, additional, Iglesias, Marina, additional, Jara-Palomares, Luis, additional, Jesús Jaras, María, additional, Joya, María Dolores, additional, Jou, Inés, additional, Lacruz, Beatriz, additional, Lalueza, Antonio, additional, Lecumberri, Ramón, additional, Lima, Jorge, additional, Llamas, Pilar, additional, Luis Lobo, José, additional, López-Jiménez, Luciano, additional, López-Miguel, Patricia, additional, José López-Núñez, Juan, additional, López-Reyes, Raquel, additional, Bosco López-Sáez, Juan, additional, Alejandro Lorente, Manuel, additional, Lorenzo, Alicia, additional, Loring, Mónica, additional, Lumbierres, Marina, additional, Madridano, Olga, additional, Maestre, Ana, additional, Javier Marchena, Pablo, additional, Martín-Fernández, Miguel, additional, Miguel Martín-Guerra, Javier, additional, Martín-Martos, Francisco, additional, Mellado, Meritxel, additional, Mercado, María Isabel, additional, Moisés, Jorge, additional, del Valle Morales, María, additional, Muñoz-Blanco, Arturo, additional, Muñoz-Guglielmetti, Diego, additional, Antonio Nieto, José, additional, Jesús Núñez, Manuel, additional, Ortega-Michel, María Carmen Olivares, Clara, additional, Dolores Ortega-Recio, María, additional, Osorio, Jeisson, additional, Otero, Remedios, additional, Paredes, Diana, additional, Parra, Pedro, additional, Parra, Virginia, additional, Pedrajas, José María, additional, Pellejero, Galadriel, additional, Pérez-Ductor, Cristina, additional, Asunción Pérez-Jacoíste, María, additional, Pesántez, David, additional, Porras, José Antonio, additional, Portillo, José, additional, Reig, Lluis, additional, Riera-Mestre, Antoni, additional, Rivas, Agustina, additional, Rodríguez-Cobo, Ana, additional, Rodríguez-Galán, Irene, additional, Rodríguez-Matute, Consolación, additional, Rosa, Vladimir, additional, María Rubio, Carmen, additional, Ruiz-Artacho, Pedro, additional, Ruiz-Giménez, Nuria, additional, Ruiz-Ruiz, Justo, additional, Ruiz-Sada, Pablo, additional, Ruiz-Torregrosa, Paloma, additional, Carles Sahuquillo, Joan, additional, Salgueiro, Giorgina, additional, Sampériz, Ángel, additional, Sancho, Teresa, additional, Soler, Silvia, additional, Suárez, Susana, additional, María Suriñach, José, additional, Tiberio, Gregorio, additional, Isabel Torres, María, additional, Tolosa, Carlos, additional, Trujillo-Santos, Javier, additional, Uresandi, Fernando, additional, Usandizaga, Esther, additional, Valle, Reina, additional, Ramón Vela, Jeronimo, additional, Vidal, Gemma, additional, Villares, Paula, additional, Zamora, Carles, additional, Gutiérrez, Paula, additional, Javier Vázquez, Fernando, additional, Vanassche, Thomas, additional, Vandenbriele, Christophe, additional, Verhamme, Peter, additional, Hirmerova, Jana, additional, Malý, Radovan, additional, Salgado, Estuardo, additional, Benzidia, Ilham, additional, Bura-Riviere, Alessandra, additional, Crichi, Benjamin, additional, Debourdeau, Philippe, additional, Farge-Bancel, Dominique, additional, Helfer, Hélène, additional, Mahé, Isabelle, additional, Moustafa, Farès, additional, Poenou, Geraldine, additional, Schellong, Sebastian, additional, Braester, Andrei, additional, Brenner, Benjamin, additional, Tzoran, Inna, additional, Amitrano, María, additional, Bilora, Franca, additional, Bortoluzzi, Cristiano, additional, Brandolin, Barbara, additional, Bucherini, Eugenio, additional, Ciammaichella, Maurizio, additional, Colaizzo, Donatella, additional, Dentali, Francesco, additional, Micco, Pierpaolo Di, additional, Giammarino, Eliana, additional, Grandone, Elvira, additional, Maggi, Fabio, additional, Mangiacapra, Sara, additional, Mastroiacovo, Daniela, additional, Maida, Rosa, additional, Pace, Federica, additional, Pesavento, Raffaele, additional, Pomero, Fulvio, additional, Prandoni, Paolo, additional, Quintavalla, Roberto, additional, Rocci, Anna, additional, Siniscalchi, Carmine, additional, Tiraferri, Eros, additional, Tufano, Antonella, additional, Visonà, Adriana, additional, Hong, Ngoc Vo, additional, Zalunardo, Beniamino, additional, Kalejs, Roberts V., additional, Kigitovica, Dana, additional, Skride, Andris, additional, Ferreira, Melanie, additional, Meireles, Jose, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Krstevski, Gorjan, additional, Zdraveska, Marija, additional, Bounameaux, Henri, additional, Mazzolai, Lucia, additional, Caprini, Joseph A., additional, Tafur, Alfonso J., additional, Weinberg, Ido, additional, Wilkins, Hannah, additional, and My Bui, Hanh, additional

Published
2020
Full Text
View/download PDF

11. Clinical characteristics and outcomes of venous thromboembolic events after hallux valgus surgery: insights from the RIETE registry

Author

Bikdeli, Bavand, primary, Visvanathan, Renuka, additional, Weinberg, Ido, additional, Rivas, Agustina, additional, Nieto, José Antonio, additional, Sampériz, Ángel, additional, Loring, Mónica, additional, Vázquez, Fernando Javier, additional, Yoo, Hugo Hyung Bok, additional, Bikdeli, Behnood, additional, and Monreal, Manuel, additional

Published
2020
Full Text
View/download PDF

12. Predicting the risk for major bleeding in elderly patients with venous thromboembolism using the Charlson index. Findings from the RIETE.

Author

Gómez-Cuervo, Covadonga, Rivas, Agustina, Visonà, Adriana, Ruiz-Giménez, Nuria, Blanco-Molina, Ángeles, Cañas, Inmaculada, Portillo, José, López-Miguel, Patricia, Flores, Katia, Monreal, Manuel, the RIETE Investigators, Prandoni, Paolo, Brenner, Benjamin, Farge-Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, and Reis, Abilio

Abstract

Old patients receiving anticoagulant therapy for venous thromboembolism (VTE) are at an increased risk for bleeding. We used data from the RIETE registry to assess the prognostic ability of the Comorbidity Charlson Index (CCI) to predict the risk for major bleeding in patients aged > 75 years receiving anticoagulation for VTE beyond the third month. We calculated the area under the receiver-operating characteristic curve (AUC), the category-based net reclassification index (NRI) and the net benefit (NB). We included 4303 patients with a median follow-up of 706 days (interquartile range [IQR] 462–1101). Of these, 147 (3%) developed major bleeding (27 died of bleeding). The AUC was 0.569 (95% CI 0.524–0.614). Patients with CCI ≤ 4 points were at a lower risk for adverse outcomes than those with CCI > 10 (major bleeding 0.81 (95% CI 0.53–1.19) vs. 2.21 (95% CI 1.18–3.79) per 100 patient-years; p < 0.05; all-cause death 1.9 (95% CI 1.45–2.44) vs. 15.67 (95% CI 12.63–19.22) per 100 patient-years; p < 0.05). A cut-off point of 4 points (CCI4) had a sensitivity of 82% (95% CI 75–89) and a specificity of 30% (95% CI 29–31) to predict major bleeding beyond the third month. CCI4 reclassification improved the NB of the RIETE bleeding score to predict bleeding beyond the third month (CCI4 NB 1.78% vs. RIETE NB 0.44%). Although the AUC of the CCI to predict major bleeding was modest, it could become an additional help to select patients aged > 75 years that obtain more benefit of extended anticoagulation, due to a lower risk for bleeding and better survival. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

14. Edoxaban for the Long‐Term Therapy of Venous Thromboembolism: Should the Criteria for Dose Reduction be Revised?

Author

Camporese, Giuseppe, Simioni, Paolo, Di Micco, Pierpaolo, Fernández‐Capitán, Carmen, Rivas, Agustina, Font, Carme, Sahuquillo, Joan Carles, Villares, Paula, Prandoni, Paolo, and Monreal, Manuel

Subjects
THROMBOEMBOLISM, DRUG efficacy, EDOXABAN, METADATA, DEATH rate
Abstract

Edoxaban is used for venous thromboembolism (VTE) treatment. Real‐life data are lacking about its use in long‐term therapy. We aimed to assess the efficacy and the safety of edoxaban for long‐term VTE treatment in a real‐life setting. Patients with VTE included in the Registro Informatizado Enfermedad TromboEmbólica (RIETE) registry, receiving edoxaban 60 or 30 mg daily were prospectively followed up to validate the benefit of using different dosages. The main outcome was the composite of VTE recurrences or major bleeding in patients with or without criteria for dose reduction. Multivariable analysis to identify predictors for the composite outcome was performed. From October 2015 to November 2019, 562 patients received edoxaban for long‐term therapy. Most (94%) of the 416 patients not meeting criteria for dose reduction received 60 mg daily, and 92 patients meeting criteria (63%) received 30 mg daily. During treatment, two patients developed recurrent VTE, six had major bleeding and nine died (2 from fatal bleeding). Among patients not meeting criteria for dose reduction, those receiving 30 mg daily had a higher rate of the composite event (hazard ratio (HR) 8.37; 95% confidence interval (CI) 1.12–42.4) and a significant higher mortality rate (HR 31.1; 95% CI 4.63–262) than those receiving 60 mg. Among patients meeting criteria for dose reduction, those receiving 60 mg daily had no events, and a nonsignificantly higher mortality rate (HR 5.04; 95% CI 0.54–133) than those receiving 30 mg daily. In conclusion, edoxaban seems to be effective and safe for long‐term VTE treatment in real life. Criteria for dose reduction should be reformulated. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

18. Outcome of Patients with Venous Thromboembolism and Factor V Leiden or Prothrombin 20210 Carrier Mutations During the Course of Anticoagulation

Author

Tzoran, Inna, primary, Papadakis, Manolis, additional, Brenner, Benjamin, additional, Fidalgo, Ángeles, additional, Rivas, Agustina, additional, Wells, Philip S., additional, Gavín, Olga, additional, Adarraga, María Dolores, additional, Moustafa, Farès, additional, Monreal, Manuel, additional, Decousus, Hervé, additional, Prandoni, Paolo, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Wells, Philip, additional, Adarraga, M.D., additional, Aibar, M.A., additional, Alfonso, M., additional, Arcelus, J.I., additional, Barba, R., additional, Barrón, M., additional, Barrón-Andrés, B., additional, Bascuñana, J., additional, Blanco-Molina, A., additional, Bueso, T., additional, Cañada, G., additional, Cañas, I., additional, Chic, N., additional, del Pozo, R., additional, del Toro, J., additional, Díaz-Pedroche, M.C., additional, Díaz-Peromingo, J.A., additional, Falgá, C., additional, Fernández-Capitán, C., additional, Fidalgo, M.A., additional, Font, C., additional, Font, L., additional, Gallego, P., additional, García, A., additional, García, M.A., additional, García-Bragado, F., additional, García-Brotons, P., additional, Gavín, O., additional, Gómez, C., additional, Gómez, V., additional, González, J., additional, González-Marcano, D., additional, Grau, E., additional, Grimón, A., additional, Guijarro, R., additional, Gutiérrez, J., additional, Hernández-Comes, G., additional, Hernández-Blasco, L., additional, Hermosa-Los Arcos, M.J., additional, Jara-Palomares, L., additional, Jaras, M.J., additional, Jiménez, D., additional, Joya, M.D., additional, Llamas, P., additional, Lecumberri, R., additional, Lobo, J.L., additional, López, P., additional, López-Jiménez, L., additional, López-Reyes, R., additional, López-Sáez, J.B., additional, Lorente, M.A., additional, Lorenzo, A., additional, Maestre, A., additional, Marchena, P.J., additional, Martín-Martos, F., additional, Monreal, M., additional, Nieto, J.A., additional, Nieto, S., additional, Núñez, A., additional, Núñez, M.J., additional, Odriozola, M., additional, Otero, R., additional, Pedrajas, J.M., additional, Pérez, G., additional, Pérez-Ductor, C., additional, Peris, M.L., additional, Porras, J.A., additional, Reig, O., additional, Riera-Mestre, A., additional, Riesco, D., additional, Rivas, A., additional, Rodríguez, C., additional, Rodríguez-Dávila, M.A., additional, Rosa, V., additional, Ruiz-Giménez, N., additional, Sahuquillo, J.C., additional, Sala-Sainz, M.C., additional, Sampériz, A., additional, Sánchez-Martínez, R., additional, Sánchez Simón-Talero, R., additional, Sanz, O., additional, Soler, S., additional, Suriñach, J.M., additional, Torres, M.I., additional, Trujillo-Santos, J., additional, Uresandi, F., additional, Valero, B., additional, Valle, R., additional, Vela, J., additional, Vicente, M.P., additional, Villalobos, A., additional, Vanassche, T., additional, Verhamme, P., additional, Wells, P., additional, Hirmerova, J., additional, Malý, R., additional, Tomko, T., additional, del Pozo, G., additional, Salgado, E., additional, Sánchez, G.T., additional, Bertoletti, L., additional, Bura-Riviere, A., additional, Mahé, I., additional, Merah, A., additional, Moustafa, F., additional, Papadakis, M., additional, Braester, A., additional, Brenner, B., additional, Tzoran, I., additional, Antonucci, G., additional, Barillari, G., additional, Bilora, F., additional, Bortoluzzi, C., additional, Cattabiani, C., additional, Ciammaichella, M., additional, Di Biase, J., additional, Di Micco, P., additional, Duce, R., additional, Ferrazzi, P., additional, Giorgi-Pierfranceschi, M., additional, Grandone, E., additional, Imbalzano, E., additional, Lodigiani, C., additional, Maida, R., additional, Mastroiacovo, D., additional, Pace, F., additional, Pesavento, R., additional, Pinelli, M., additional, Poggio, R., additional, Prandoni, P., additional, Rota, L., additional, Tiraferri, E., additional, Tonello, D., additional, Tufano, A., additional, Visonà, A., additional, Zalunardo, B., additional, Gibietis, V., additional, Skride, A., additional, Vitola, B., additional, Monteiro, P., additional, Ribeiro, J.L., additional, Sousa, M.S., additional, Bosevski, M., additional, Zdraveska, M., additional, Bounameaux, H., additional, Calanca, L., additional, Erdmann, A., additional, and Mazzolai, L., additional

Published
2017
Full Text
View/download PDF

19. Sex Differences in Patients With Occult Cancer After Venous Thromboembolism.

Author

Jara-Palomares, Luis, Otero, Remedios, Jiménez, David, Praena-Fernández, Juan Manuel, Rivas, Agustina, Font, Carme, Wells, Philip S., López-Reyes, Raquel, González-Martínez, José, and Monreal, Manuel

Abstract

In patients with venous thromboembolism (VTE), male sex has been associated with an increased risk of occult cancer. The influence of sex on clinical characteristics, treatment, cancer sites, and outcome has not been thoroughly investigated yet. We used the Registro Informatizado Enfermedad TromboEmbólica registry to compare the clinical characteristics, treatment strategies, cancer sites, and clinical outcomes in patients with VTE having occult cancer, according to sex. As of June 2014, 5864 patients were recruited, of whom 444 (7.6%; 95% confidence interval: 6.8-8.2) had occult cancer. Of these, 246 (55%) were men. Median time elapsed from VTE to occult cancer was 4 months (interquartile range: 2-8.4), with no sex differences. Women were older, weighed less, and were less likely to have chronic lung disease than men. The most common cancer sites were the lung (n = 63), prostate (n = 42), and colorectal (n = 29) in men and colorectal (n = 38), breast (n = 23), uterine (n = 18), hematologic (n = 17), or pancreas (n = 15) in women. Men were more likely to have lung cancer than women (2.18% vs 0.30%; P < .01) and less likely to have pancreatic cancer (0.17% vs 0.5%; P = .03). Interestingly, breast cancer was more likely found in women aged ≥50 years than in those aged <50 years (0.97% vs 0.14%; P = .03). This study highlights the existence of sex differences in patients with VTE having occult cancer. One in every 2 men had lung, prostate, or colorectal cancer. In women, there is a heterogeneity of cancer sites, increasing risk of breast cancer in those aged >50 years. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

20. Edoxaban for the Long-Term Therapy of Venous Thromboembolism: Should the Criteria for Dose Reduction be Revised?

Author

Camporese G, Simioni P, Di Micco P, Fernández-Capitán C, Rivas A, Font C, Sahuquillo JC, Villares P, Prandoni P, and Monreal M

Subjects
Aged, Aged, 80 and over, Anticoagulants adverse effects, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Hemorrhage chemically induced, Hemorrhage prevention & control, Humans, Male, Middle Aged, Practice Guidelines as Topic, Prospective Studies, Pyridines adverse effects, Recurrence, Registries statistics & numerical data, Thiazoles adverse effects, Time Factors, Venous Thromboembolism mortality, Anticoagulants administration & dosage, Drug Tapering standards, Hemorrhage epidemiology, Pyridines administration & dosage, Thiazoles administration & dosage, Venous Thromboembolism drug therapy
Abstract

Edoxaban is used for venous thromboembolism (VTE) treatment. Real-life data are lacking about its use in long-term therapy. We aimed to assess the efficacy and the safety of edoxaban for long-term VTE treatment in a real-life setting. Patients with VTE included in the Registro Informatizado Enfermedad TromboEmbólica (RIETE) registry, receiving edoxaban 60 or 30 mg daily were prospectively followed up to validate the benefit of using different dosages. The main outcome was the composite of VTE recurrences or major bleeding in patients with or without criteria for dose reduction. Multivariable analysis to identify predictors for the composite outcome was performed. From October 2015 to November 2019, 562 patients received edoxaban for long-term therapy. Most (94%) of the 416 patients not meeting criteria for dose reduction received 60 mg daily, and 92 patients meeting criteria (63%) received 30 mg daily. During treatment, two patients developed recurrent VTE, six had major bleeding and nine died (2 from fatal bleeding). Among patients not meeting criteria for dose reduction, those receiving 30 mg daily had a higher rate of the composite event (hazard ratio (HR) 8.37; 95% confidence interval (CI) 1.12-42.4) and a significant higher mortality rate (HR 31.1; 95% CI 4.63-262) than those receiving 60 mg. Among patients meeting criteria for dose reduction, those receiving 60 mg daily had no events, and a nonsignificantly higher mortality rate (HR 5.04; 95% CI 0.54-133) than those receiving 30 mg daily. In conclusion, edoxaban seems to be effective and safe for long-term VTE treatment in real life. Criteria for dose reduction should be reformulated., (© 2020 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of the American Society of Clinical Pharmacology & Therapeutics.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results