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1. Computational study of the structure and catalytic mechanism of xylene monooxygenase from Pseudomonas putida

Author

Sassi, T, Arrigoni, F, Bertini, L, Rizza, F, Rebuzzini, G, Vanoni, M, Brambilla, L, Brambilla, L. G., Sassi, T, Arrigoni, F, Bertini, L, Rizza, F, Rebuzzini, G, Vanoni, M, Brambilla, L, and Brambilla, L. G.

Abstract

Xylene monooxygenase (XMO) from Pseudomonas putida stands out for its ability to oxidize inert substrates with a structure like toluene and xylene. Nevertheless, its catalytic efficacy is curtailed by a mysterious inhibition mechanism, the details of which remain elusive. Presently, our research endeavors focus on employing wet and computational methodologies to unravel the structural intricacies and catalytic dynamics of XMO atoms. This enzyme exhibits high sequence homology with alkane monooxygenase (alkB), with its distinctive catalytic site where two iron atoms are situated at an unusual distance of 6 Å within a histidine-rich environment. This peculiar catalytic site underlines a catalytic mechanism unknown to this day. While our investigation is ongoing, our preliminary molecular modeling and simulation efforts aim to shed light on the fundamental aspects of its function and inhibition. Through this ongoing work, we anticipate laying the groundwork for potential strategies to enhance the stability and efficiency of XMO. Our endeavors hold significant promise for advancing both the fundamental understanding and practical applications of XMO in biotechnological contexts such as industrial processes.

Published
2024

2. Genetic diversity in Mediterranean Brassica vegetables: seed phenotyping could be useful for sustainable crop production

Author

Wagner, M.H., primary, Aïssiou, F., additional, Badeck, F.W., additional, Deniot, G., additional, Ducournau, S., additional, Dupont, A., additional, Falentin, C., additional, Gay, L., additional, Geraci, A., additional, Glory, P., additional, Hadj-Arab, H., additional, Jarillo José, A., additional, Meglic, V., additional, Morcia, C., additional, Pipan, B., additional, Sinkovic, L., additional, Oddo, E., additional, Pernas, M., additional, Pineiro, M., additional, Richer, V., additional, Rizza, F., additional, Ronfort, J., additional, Schicchi, R., additional, Terzi, V., additional, and Chèvre, A.M., additional

Published
2023
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3. Toward Diiron Dithiolato Biomimetics with Rotated Conformation of the [FeFe]-Hydrogenase Active Site: A DFT Case Study on Electron-Rich, Isocyanide-Based Scaffolds

Author

Arrigoni, F, Rizza, F, Bertini, L, De Gioia, L, Zampella, G, Arrigoni F., Rizza F., Bertini L., De Gioia L., Zampella G., Arrigoni, F, Rizza, F, Bertini, L, De Gioia, L, Zampella, G, Arrigoni F., Rizza F., Bertini L., De Gioia L., and Zampella G.

Abstract

The electron rich Fe2(pdt)(RNC)6 1 (pdt=CH2(CH2S−)2) has been used as starting point for a DFT multi-functional study to assess the feasibility of designing a stable inverted (or rotated) disposition of the two FeL3 pyramidal moieties in the dimetallic core, a key feature of [FeFe]-hydrogenase cofactor. The choice of 1 was motivated by the presence of a rotated form in solution, slightly less stable than the unrotated stereoisomer. Aimed to find an upgraded version of 1, featuring the rotated isomer as ground state, various combinations of factors have been tested, for their effect on the relative stability of rotated vs unrotated isomers. The general result is that combining coordination asymmetry, electron donor presence and isocyanides R substituents able to establish intramolecular interactions is effective in stabilizing the rotated isomer. Our DFT study may inspire the design of synthetic biomimetics, with improved resemblance to the natural system.

Published
2022

5. Theoretical Investigation of Inorganic Particulate Matter: The Case of Water Adsorption on a NaCl Particle Model Studied Using Grand Canonical Monte Carlo Simulations

Author

Rizza, F, Rovaletti, A, Carbone, G, Miyake, T, Greco, C, Cosentino, U, Rizza, Fabio, Rovaletti, Anna, Carbone, Giorgio, Miyake, Toshiko, Greco, Claudio, Cosentino, Ugo, Rizza, F, Rovaletti, A, Carbone, G, Miyake, T, Greco, C, Cosentino, U, Rizza, Fabio, Rovaletti, Anna, Carbone, Giorgio, Miyake, Toshiko, Greco, Claudio, and Cosentino, Ugo

Abstract

Sodium chloride (NaCl) represents the principal component of atmospheric particulates of marine origin. To gain a molecular-level understanding of the adsorption process of water vapor on the NaCl surface, Monte Carlo simulations performed in the Grand Canonical ensemble were carried out, considering the water adsorption at different water pressures on a NaCl(001) surface. The calculated adsorption isotherm shows four different regions, whose coverages correspond to those of the low-, transition-, high-, and pre-solution-coverage regions experimentally observed. Detailed analysis reveals how the structure of the adsorbed water molecules (islands, layer, and multi-layer) changes depending on water pressure, and how their orientation with respect to the surface varies with the distance from the surface. This detailed information further supports the picture coming from previous experimental IR absorption spectroscopy studies.

Published
2023

6. Effect of Rehabilitation Treatments on Disability in Persons With Disorders of Consciousness: A Propensity Score Study

Author

Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., Semerjian M., Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, and Semerjian, M

Subjects
Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Propensity score, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Disorders of consciousness, Severity of Illness Index, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, Severity of illness, medicine, Humans, Longitudinal Studies, Aged, Vegetative state, Rehabilitation, business.industry, Minimally conscious state, Recovery of Function, Disability Rating Scale, Middle Aged, medicine.disease, Treatment Outcome, Italy, Propensity score matching, Physical therapy, Consciousness Disorders, Female, Observational study, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract

To evaluate the effects of rehabilitation (physical and cognitive) treatments on the diagnosis severity and Disability Rating Scale (DRS) scores, adjusted for a number of potential confounders measured at baseline, in a large cohort of patients with disorders of consciousness across time.An observational, longitudinal (2 evaluations), multicenter project was made in 90 Italian centers.Patients (N=364) with a diagnosis of disorders of consciousness.Primary outcome was the severity of diagnosis, expressed on an ordinal scale (OtherMCSVSdeath). In the Other group were included patients who emerged from an MCS and recovered consciousness. The secondary outcome was the DRS score (range of 0-30 with 30 being the worst value). The DRS is a tool used to define the level of residual disability, commonly used to classify the level of functional impairment in patients with acquired brain injury. Both outcomes were measured for each wave.A total of 364 subjects having a complete set of demographic, clinical, and pharmacologic data were included in the propensity score (PS) analysis. Results showed that the rehabilitation treatments (physical and cognitive) reduced the clinical worsening over time in both severity diagnosis and DRS (around 6.5 points) in patients with disorders of consciousness across different propensity score strategies (ie, PS matching, PS adjustment, and PS-weighted procedures). In addition, cognitive protocols seem to be limited to patients with a median value of DRS=23.Our propensity score analysis suggests that rehabilitation treatment protocols seem effective and should be applied to a broader spectrum of patients with disorders of consciousness.

Published
2020
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7. Antibacterial Activity of Rosemary Oil Against Propionibacterium acnes and The Formulation into Nanoemulsion System

Author

Sani Ega Priani, Rizza F. Nurasyfa, G.C. Eka Darma, Sri P. Fitraningsih, Livia Syafnir, and Robby Prayitno

Subjects
Applied Mathematics, General Mathematics
Abstract

Acne is an inflammatory condition of the pilosebaceous unit that can occur due to infection ofPropionibacterium acnes. Rosemary essential oil contains various active compounds that haveantibacterial activity. Nanoemulsions have been developed as a delivery system to the pilosebaceousunit. This study aimed to determine the antibacterial activity of rosemary oil against P. acnes anddevelop it into a nanoemulsion system. The antibacterial activity was conducted by the agar diffusionmethod. Rosemary oil contains 1,8-cineole as the main active compound and has antibacterial activityagainst P. acnes with an inhibitory zone of 11.315±0.069 mm at a concentration of 4%. Rosemaryoil was successfully developed into a nanoemulsion system using Tween 80 as a surfactant and acombination of ethanol and PEG 400 as a co-surfactant. The rosemary nanoemulsion has a clearphysical appearance with an average globule size of 33.50±0.01 nm and a PDI value of 0.45±0.03. Thepreparation has good physical stability based on centrifugation, heating cooling, and freeze-thaw tests.The study shows that rosemary oil has antibacterial activity against P. acnes and has been successfullydeveloped into nanoemulsion preparations with good characteristics and physical stability. Keywords: Acne vulgaris, Nanoemulsion, Propionibacterium acnes, Rosemary oil.

Published
2023
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11. Effect of Rehabilitation Treatments on Disability in Persons With Disorders of Consciousness: A Propensity Score Study

Author

Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, Semerjian, M, Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., Semerjian M., Sattin, D, Leonardi, M, Nelli, B, Bramanti, P, Marino, S, Ferro, S, Basaglia, N, Guido, D, Dolce, G, Lucca, L, Cortese, M, Ermio, C, Dattilo, T, Capomolla, S, Di Iasi, G, Estraneo, A, De Tanti, A, Maradini, N, Piperno, R, Ferri, A, Bergonzoni, A, Chiavaroli, F, Di Marco, F, Carli, S, Biasutti, E, Marin, D, Formisano, R, Rizza, F, Pisarri, F, Vichi, R, D'Urso, A, Grillo, G, Leto, A, Guerrasio, M, Taliento, C, Napolitano, F, Castelli, E, Lispi, M, Diverio, M, Barbieri, C, Bini, P, Angelino, G, Dada, O, Orlandi, A, Pistarini, C, Pisoni, C, Manera, M, Compostini, A, Aiachini, B, Pessina, A, Musio, A, Colombetti, E, Taraschi, S, Aluas, M, Croci, M, Negri, M, Zucchella, M, Guizzetti, G, Salamone, E, De Valle, G, Caroppi, S, Ramorino, E, Salina, D, Spannocchi, G, Strazzer, S, Villa, F, Guarnerio, C, Chiambretto, P, Dartizio, R, Feller, S, Franzoni, L, Giunco, F, Massironi, L, Azimonti, R, Marcolli, S, Meinecke, C, Buse, G, Marchesi, V, Molteni, F, Gramigna, C, Lanfranchi, M, Pisani, L, Sozzi, M, Borri, G, Cannata, A, Grillo, A, Roca, S, Locati, D, Arenare, F, Magnoni, A, Perin, C, Sussele, M, Quintana, T, Camici, M, Magistrelli, F, Samueli, T, San Felici, L, Manganelli, F, Vignati, M, Bellanova, L, Cattaneo, N, Ferraro, F, Olgiati, E, Brizioli, E, Vallasciani, M, Gironelli, L, Calderisi, E, Novelli, A, Scaramuzzo, R, Perino, C, Forno, R, Zamponi, E, Corna, S, Ferrario, S, Lamberti, G, Rosso, S, Colonna, F, Navarro, J, Trabacca, A, Gennaro, L, Bertolini, A, Addante, L, Amenduni, M, Fiore, P, Amoruso, M, Colella, D, Angelillo, M, Melis, G, Desogus, G, Baglieri, A, Galardi, G, Sant'Angelo, A, Posteraro, F, Forte, F, Logi, F, Potenza, F, Lino, M, Zaccara, G, Ragazzoni, A, Chiaramonti, R, March, A, Grober, G, Kaczor, M, Zelger, P, Mazzini, N, Monti, A, Zampolini, M, Scarponi, F, Avesani, R, Salvi, L, Tonin, P, Cosentino, E, Furlanetto, N, Bordin, M, Martinuzzi, A, Buffoni, M, Boldrini, P, Semerjian, M, Sattin D., Leonardi M., Nelli B., Bramanti P., Marino S., Ferro S., Basaglia N., Guido D., Dolce G., Lucca L. F, Cortese M. D., Ermio C., Dattilo T. L., Capomolla S., Di Iasi G., Estraneo A., De Tanti A., Maradini N., Piperno R., Ferri A., Basaglia N, Bergonzoni A., Chiavaroli F., Di Marco F., Carli S., Biasutti E., Marin D., Formisano R., Rizza F., Pisarri F. M., Vichi R., D'Urso A., Grillo G., Leto A., Guerrasio M., Taliento C., Napolitano F., Castelli E., Lispi M. L., Diverio M., Barbieri C., Bini P. P., Angelino G., Dada O., Orlandi A., Pistarini C., Pisoni C., Manera M., Compostini A., Aiachini B., Pessina A., Musio A., Colombetti E., Taraschi S., Aluas M., Croci M., Negri M., Zucchella M. A., Guizzetti G. B., Salamone E., De Valle G., Caroppi S. M., Ramorino E., Salina D., Spannocchi G., Strazzer S., Villa F., Guarnerio C., Chiambretto P., Dartizio R., Feller S., Franzoni L., Giunco F., Massironi L., Azimonti R., Marcolli S. S., Meinecke C., Buse G., Marchesi V, Molteni F., Gramigna C., Lanfranchi M., Pisani L., Sozzi M., Borri G., Cannata A. P., Grillo A., Roca S., Locati D., Arenare F., Magnoni A., Perin C., Sussele M., Quintana T. Y., Camici M. E., Magistrelli F., Samueli T., San Felici L., Manganelli F., Vignati M., Bellanova L., Cattaneo N., Ferraro F., Olgiati E., Brizioli E., Vallasciani M., Gironelli L., Calderisi E., Novelli A., Scaramuzzo R., Perino C., Forno R., Zamponi E., Corna S., Ferrario S., Lamberti G., Rosso S., Colonna F., Navarro J., Trabacca A., Gennaro L., Bertolini A., Addante L., Amenduni M. T., Fiore P., Amoruso M. T., Colella D., Angelillo M. T., Melis G., Desogus G., Baglieri A., Galardi G., Sant'Angelo A., Posteraro F., Forte F., Logi F., Potenza F., Lino M., Zaccara G., Ragazzoni A., Chiaramonti R., March A., Grober G., Kaczor M., Zelger P, Mazzini N., Monti A., Zampolini M., Scarponi F., Avesani R., Salvi L., Tonin P., Cosentino E., Furlanetto N., Bordin M., Martinuzzi A., Buffoni M., Boldrini P., and Semerjian M.

Abstract

Objective: To evaluate the effects of rehabilitation (physical and cognitive) treatments on the diagnosis severity and Disability Rating Scale (DRS) scores, adjusted for a number of potential confounders measured at baseline, in a large cohort of patients with disorders of consciousness across time. Design and Setting: An observational, longitudinal (2 evaluations), multicenter project was made in 90 Italian centers. Participants: Patients (N=364) with a diagnosis of disorders of consciousness. Main Outcome Measures: Primary outcome was the severity of diagnosis, expressed on an ordinal scale (Other

Published
2020

18. Use of a water stress index to identify barley genotypes adapted to rainfed and irrigated conditions

Author

Rizza, F., Badeck, F.W., Cattivelli, L., Lidestri, O., Di Fonzo, N., and Stanca, A.M.

Subjects
Barley -- Research, Agricultural industry, Business, Research
Abstract

Future climate changes are expected to increase risks of drought, which already represent the most common stress factor for stable barley (Hordeum vulgate L.) production in Mediterranean areas. It is important, therefore, to evaluate if there are needs of specific adaptive measures in selecting genotypes for these more stressful environments. Our objective was to study diversity of yield performance under raiufed (R) and irrigated (I) conditions in 89 barley genotypes of different origin, growth habit, and year of release, representing a sample of cultivars grown in Europe. The experiment was conducted at Foggia (southern Italy) for 3 yr. For each trial, a water stress index (WSI) was calculated on the basis of the daily potential and actual evapotranspiration in the growing season, estimated by Thornthwaite's method. The WSI explained most of the variation in yield ([R.sup.2] = 0.89 **) among years and treatments. We examined, using the yield vs. WSI regression, the behavior of a given genotype across trials. The intercept and slope values were used as measures of yield potential and adaptability under drought, respectively. Several cultivars showing high yield potential and minimal genotype x environment (GE) interaction were identified. Notably, they were characterized by a high slope of the yield vs. WSI regression. Furthermore, within the range of water stress here examined, high yield potential played a preeminent role in the performance of these barley genotypes. This explains why, in this specific context, a selection based on minimum yield decrease under stress with respect to favorable conditions failed to identify the best genotypes., THE MEDITERRANEAN REGION OF EUROPE is particularly sensitive to drought and potentially very vulnerable to future climate changes. Even if rainfall does not change, increased risks for drought will result [...]

Published
2004

24. Monitoring the quality of laboratories and the prevalence of resistance to antituberculosis drugs: Italy, 1998–2000

Author

Migliori, G. B., Fattorini, L., Vaccarino, R., Besozzi, G., Saltini, C., Orefici, G., Iona, E., Matteelli, A., Fiorentini, F., Codecasa, L. R., Casali, Lucio, Cassone, A., De Santis, A., Giorgio, V., Vinciguerra, P., Angarano, G., Petrozzi, L., Costa, D., Gozzellino, F., Perboni, A., Marchetti, D., Pascali, A., Falcone, F., Mariano, V., Rizza, F., Pretto, P., Turano, A., Carosi, G. P., Farris, A. G., Ligia, G. P., Orani, G., Farris, B., Foschi, C., Trucco, G., Aiolfi, S., Ceruti, T., Parpanesi, M., Calabro, S., Felisatti, G., Tortoli, E., Nutini, S., Montini, G., D'Ambrosio, V., Ceraminiello, A., Bernorio, S., Buono, L., Montesano, P., Vinci, E., Sabato, E., Gamba, S., Crepaldi, P., Magliano, E., Penati, V., Vaccarino, P., Astolfi, A., Bertoli, G., Rupianesi, F., Losi, M., Richeldi, L., Ferrara, Giovanni, Minuccio, E., Napolitano, G., Molinari, G. L., Saini, L., Garzone, A., Vertuccio, C., Marcias, S., Menozzi, M., Marone, P., Peona, V., Nascimbene, C., Pasi, A., Cascina, A., Monaco, A., Penza, O., Pasticci, Maria Bruna, Bistoni, F., Sposini, T., Colorizio, V., Confalonieri, M., Bottrighi, P., Macor, G., Moretti, G., Fatigante, R., Barbaro, A., Agati, G., Zaccara, F., Viola, S., Le Donne, R., Farinelli, G., Mancini, D., Ermeti, M., Longi, R., Tronci, M., Bisetti, A., Altieri, A., and Fadda, G.

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, Prevalence of resistance, Drug Resistance, Antitubercular Agents, Drug resistance, Proficiency testing, Drug, Immigrant, Susceptibility testing, Emigration and Immigration, Humans, Italy, Laboratories, Prevalence, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, Internal medicine, medicine, Ethambutol, business.industry, Public health, Isoniazid, Bacterial, Multidrug-Resistant, medicine.disease, Surgery, Streptomycin, business, Multiple, Rifampicin, medicine.drug
Abstract

In 1998 a network of 20 regional tuberculosis (TB) laboratories (the Italian Multicentre Study on Resistance to Antituberculosis drugs (SMIRA) network) was established in Italy to implement proficiency testing and to monitor the prevalence of drug resistance nationwide. The network managed 30% of all TB cases reported in Italy each year. The aim of the present report is to describe: 1) the accuracy of drug-susceptibility testing in the network; 2) the prevalence of drug resistance for the period 1998-2000. Data were collected from the network laboratories. Sensitivity to streptomycin and ethambutol increased from the first survey (1998-1999) to the second survey (2000) from 87.7 to 91.9%. Specificity, predictive values for resistance and susceptibility, efficiency and reproducibility were consistent in both surveys. In previously untreated cases, the prevalence of multidrug-resistance was the same in both surveys (1.2%), while a slight decrease from the first to the second survey was observed for monoresistance to rifampicin (from 0.8 to 0.4%) and isoniazid (from 2.9 to 2%). The significant association found between isoniazid resistance and immigration is a useful indicator for both clinicians managing individual tuberculosis cases and public health services planning control strategies.

Published
2003
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25. The epidemiology of Varicella Zoster Virus infection in Italy

Author

GABUTTI G, ROTA MC, GUIDO M, DE DONNO A, BELLA A, DEGLI ATTI ML, CROVARI P, SEROEPIDEMIOLOGY GROUP, BASSETTI D, BECHINI A, BOCCALINI S, BONANNI P, CACIAGLI P, CAMPER A, CAMPA AM, CARACCIO W, CAVALLARO A, CIAMARRA E, CLERICO L, CASENTINO L, DE SIMONE E, FAVERO A, FOCÀ A, GENNA L, GIAMMANCO, Anna, GIANCOTTI A, GOGLIO A, GRANDESSO S, ICARDI GC, LOLLI C, MARCHETTI D, MARSELLA M, MARTELLI P, MUCIGNAT L, PALLADINO D, PASSERINI C, PERANI V, PISCIONE E, RIZZA F, ROLLO MC, SIMULA L, SFORZA R, TAGLIATATELA D, TRONCI M, VILLALTA D., GABUTTI G, ROTA MC, GUIDO M, DE DONNO A, BELLA A, DEGLI ATTI ML, CROVARI P, SEROEPIDEMIOLOGY GROUP, BASSETTI D, BECHINI A, BOCCALINI S, BONANNI P, CACIAGLI P, CAMPER A, CAMPA AM, CARACCIO W, CAVALLARO A, CIAMARRA E, CLERICO L, CASENTINO L, DE SIMONE E, FAVERO A, FOCÀ A, GENNA L, GIAMMANCO A, GIANCOTTI A, GOGLIO A, GRANDESSO S, ICARDI GC, LOLLI C, MARCHETTI D, MARSELLA M, MARTELLI P, MUCIGNAT L, PALLADINO D, PASSERINI C, PERANI V, PISCIONE E, RIZZA F, ROLLO MC, SIMULA L, SFORZA R, TAGLIATATELA D, TRONCI M, and VILLALTA D

Subjects
Adult, Male, Herpesvirus 3, Human, Settore MED/07 - Microbiologia E Microbiologia Clinica, Pediatrics, medicine.medical_specialty, Adolescent, Cross-sectional study, Population, Varicella, medicine.disease_cause, Young Adult, Chickenpox, Seroepidemiologic Studies, Environmental health, Epidemiology, medicine, Humans, Seroprevalence, Preschool, Child, education, Varicella Zoster,epidemiology, infection in Italy, education.field_of_study, business.industry, lcsh:Public aspects of medicine, Herpesvirus 3, Infant, Newborn, Public Health, Environmental and Occupational Health, Varicella zoster virus, Infant, virus diseases, lcsh:RA1-1270, Middle Aged, Newborn, medicine.disease, Vaccination, Cross-Sectional Studies, Italy, Infectious disease (medical specialty), Child, Preschool, Female, business, Human, Research Article
Abstract

Background The epidemiological importance of varicella and zoster and the availability of an efficacious and safe vaccine have led to an important international debate regarding the suitability of mass vaccination. The objective of the study was to describe the epidemiology of varicella and zoster in Italy and to determine whether there have been changes with respect to observations provided by an analogous study conducted 8 years ago, in order to define the most appropriate vaccination strategy. Methods A number of data sources were evaluated, a cross-sectional population-based seroprevalence study was conducted on samples collected in 2004, and the results were compared with data obtained in 1996. Results The data from active and passive surveillance systems confirm that varicella is a widespread infectious disease which mainly affects children. VZV seroprevalence did not substantially differ from that found in the previous study. The sero-epidemiological profile in Italy is different from that in other European countries. In particular, the percentage of susceptible adolescents is at least nearly twice as high as in other European countries and in the age group 20–39 yrs, approximately 9% of individuals are susceptible to VZV. Conclusion The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination.

Published
2008
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26. Guida alla scelta delle migliori varietà di triticale

Author

RIZZA F, ALBERICI R, BELOCCHI A, CANNELLA V, CARBONI G, CODIANNI P, DI PRIMA G, FACCINI N, FORNARA M, FUSELLI D, GALLO G, MUSIO F, NOTARIO T, PAGANI D, PETRINI A, PRUNEDDU G, RANDAZZO B, SIGNOR M, SNIDARO M, VIRDIS A., GIAMBALVO, Dario, GRISTINA, Luciano, MOTTA, Valentina, POMA, Ignazio, VIOLA, Paolo, RIZZA F, ALBERICI R, BELOCCHI A, CANNELLA V, CARBONI G, CODIANNI P, DI PRIMA G, FACCINI N, FORNARA M, FUSELLI D, GALLO G, GIAMBALVO D, GRISTINA L, MOTTA V, MUSIO F, NOTARIO T, PAGANI D, PETRINI A, POMA I, PRUNEDDU G, RANDAZZO B, SIGNOR M, SNIDARO M, VIOLA P, and VIRDIS A

Published
2007

27. Risultati delle prove nazionali 2005-06 - Scelta delle varietà di triticale

Author

RIZZA F, ALBERICI R, BELLOCCI A, CANNELLA V, CARBONI G, CODIANNI P, DI PRIMA G, FACCINI N, FORNARA M, FUSELLI D, GALLO G, INVERNIZZI C, MUSIO F, NOTARIO T, PAGNI D, PETRINI A, RANDAZZO B, SIGNOR M, SNIDARO M, VIRDIS A., GIAMBALVO, Dario, GRISTINA, Luciano, POMA, Ignazio, STRINGI, Luigi, RIZZA F, ALBERICI R, BELLOCCI A, CANNELLA V, CARBONI G, CODIANNI P, DI PRIMA G, FACCINI N, FORNARA M, FUSELLI D, GALLO G, GIAMBALVO D, GRISTINA L, INVERNIZZI C, MUSIO F, NOTARIO T, PAGNI D, PETRINI A, POMA I, RANDAZZO B, SIGNOR M, SNIDARO M, STRINGI L, and VIRDIS A

Published
2006

29. Leaf CO2 assimilation irradiance-response of giant reed (Arundo donax L.): comparison of four models

Author

Badeck, F.W., Rizza, F., Soave, C., Di Candilo, M., and Ceotto, E.

Subjects
Biomass
Abstract

The scope of this study was to assess the adequacy of four models (Blackman response, negative exponential, rectangular hyperbola and non-rectangular hyperbola) for describing the CO2 assimilation irradiance¬response curve in leaves of giant reed, a promising energy crop with remarkable biomass productivity in Mediterranean areas. A field study was conducted in Anzola dell'Emilia (Bologna), Northern Italy, during the year 2011, on a crop stand of giant reed established in 2007. Periodical measures of CO2 assimilation were performed on leaves of giant reed, using a gas exchange analyzer LICOR 6400. Light response curves of CO2 assimilation were measured on the third leaf from top of the plant.While it is often indicated that giant reed is a C3 crop with very high photosynthetic efficiency, prior to the present study little was known about the photosynthetic response of the species to increasing light intensity. Thus, our findings fill a gap in the current knowledge., Proceedings of the 20th European Biomass Conference and Exhibition, 18-22 June 2012, Milan, Italy, pp. 574-577

Published
2012
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30. Proficiency testing of first- and second-line anti-tuberculosis drugs in Italy

Author

Fattorini, L, Migliori, Gb, Cassone, A, Mustazzolu, A, Piccaro, G, Filippini, P, Cirillo, Dm, Borroni, E, Piersimoni, C, Costa, D, Grimaldi, A, De Santis, A, Arosio, M, Goglio, A, Mazza, C, Squintani, L, Di Pede, B, Gaspari, G, Marchetti, D, Nanetti, A, Larcher, C, Frizzera, E, Rizza, F, Pinsi, G, Turano, A, Caddeu, R, Farris, Ag, Di Naso, C, Cavalcanti, P, Tomei, G, Mantini, G, Ceruti, T, Ferrari, L, Rossi, Mr, Tortoli, E, Montini, G, Senno, E, Nisticò, S, Colonna, C, Buono, L, Mazzola, E, Gesu, G, Penati, V, Vaccarino, P, Piana, F, Cichero, P, Lombardi, A, Mantovani, G, Fabio, A, Bertoli, G, Rumpianesi, F, Santoro, G, Molinari, Gl, Camaggi, A, Chirillo, Mg, Peracchi, M, Fallico, L, Menozzi, M, Dettori, G, Marone, P, Bono, L, Matteo, S, Mazzolla, R, Sposini, T, Tiecco, C, Barbaro, A, Vecchia, L, Piscina, A, Chiaradonna, P, Tronci, M, Bordi, E, De Mori, P, Diamare, F, Libanori, E, Panaiota, T, Milano, R, Mondo, A, Barbui, A, Fabbro, L, Centis, R, D'Ambrosio, L, Spanevello, Antonio, Caola, I, Mottola, A, Fabris, C, Scagnelli, M, Screm, Mc, and Scarparo, C.

Subjects
Pulmonary and Respiratory Medicine, Treatment Outcome, Italy, Tuberculosis, Multidrug-Resistant, Antitubercular Agents, Humans, Tuberculosis, Mycobacterium tuberculosis, Pulmonary, Multidrug-Resistant, Tuberculosis, Pulmonary, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Published
2012

31. Surveillance of anti-tuberculosis drug resistance: Results of the 1998/1999 proficiency testing in Italy

Author

Migliori GB, Ambrosetti M, Fattorini L, Penati V, Vaccarino P, Besozzi G, Ortona L, Saltini C, Orefici G, Moro ML, Iona E, Cassone A, De Santis A, Giorgio V, Vinciguerra P, Angarano G, Petrozzi L, Costa D, Gozzellino F, Perboni A, Marchetti D, Pascali A, Falcone F, Mariano V, Rizza F, Pretto P, Turano A, Matteelli A, Carosi GP, Tedoldi S, Pinsi G, Farris AG, Ligia GP, Orani G, Farris B, Foschi C, Trucco G, Aiolfi S, Ceruti T, Parpanesi M, Calabro S, Felisatti G, Tortoli E, Nutini S, Montini G, Fiorentini F, D'Ambrosio V, Ceraminiello A, Bernorio S, Buono L, Montesano P, Vinci E, Sabato E, Gamba S, Crepaldi P, Bertoli G, Rupianesi F, Losi M, Richeldi L, Ferrara G, Muccio E, Napolitano G, Molinari GL, Saini L, Garzone A, Vertuccio C, Marcias, Menozzi, Marone P, Peona, Nascimbene, Pasi, Cascina, Casali, Monaco, Penza, Pasticci, M.B., Bistoni, Sposini, Colorizio, Confalonieri M, Bottrighi P, Orsi, Schiavi, Macor, Moretti, Fatigante, Barbaro, Agati, Zacarra, Viola, Le Donne, Farinelli, Mancini, Ermeti, Migliori, Gb, Ambrosetti, M, Fattorini, L, Penati, V, Vaccarino, P, Besozzi, G, Ortona, L, Saltini, C, Orefici, G, Moro, Ml, Iona, E, Cassone, A, De Santis, A, Giorgio, V, Vinciguerra, P, Angarano, G, Petrozzi, L, Costa, D, Gozzellino, F, Perboni, A, Marchetti, D, Pascali, A, Falcone, F, Mariano, V, Rizza, F, Pretto, P, Turano, A, Matteelli, A, Carosi, Gp, Tedoldi, S, Pinsi, G, Farris, Ag, Ligia, Gp, Orani, G, Farris, B, Foschi, C, Trucco, G, Aiolfi, S, Ceruti, T, Parpanesi, M, Calabro, S, Felisatti, G, Tortoli, E, Nutini, S, Montini, G, Fiorentini, F, D'Ambrosio, V, Ceraminiello, A, Bernorio, S, Buono, L, Montesano, P, Vinci, E, Sabato, E, Gamba, S, Crepaldi, P, Bertoli, G, Rupianesi, F, Losi, M, Richeldi, L, Ferrara, G, Muccio, E, Napolitano, G, Molinari, Gl, Saini, L, Garzone, A, Vertuccio, C, Marcias, Menozzi, Marone, P, Peona, Nascimbene, Pasi, Cascina, Casali, Monaco, Penza, Pasticci, M., B., Bistoni, Sposini, Colorizio, Confalonieri, M, Bottrighi, P, Orsi, Schiavi, Macor, Moretti, Fatigante, Barbaro, Agati, Zacarra, Viola, Le, Donne, Farinelli, Mancini, and Ermeti

Subjects
Tuberculosi, Drug susceptibility testing, Proficiency testing
Published
2000

35. The epidemiology of mumps in Italy

Author

Gabutti, G, Guido, M, Rota, Mc, De Donno, A, Ciofi Degli Atti ML, Crovari, P, Seroepidemiology, Group, Bassetti, D, Bechini, Angela, Boccalini, Sara, Bonanni, Paolo, Caciagli, P, Camper, A, Campa, Am, Caraccio, W, Cavallaro, A, Ciamarra, E, Clerico, L, Casentino, L, de Simone, E, Favero, A, Focà, A, Genna, L, Giammanco, A, Giancotti, A, Goglio, A, Grandesso, S, Icardi, Gc, Lolli, C, Marchetti, D, Marsella, M, Martelli, P, Mucignat, L, Palladino, D, Passerini, C, Perani, V, Piscione, E, Rizza, F, Zizza, A, Simula, L, Sforza, R, Tagliatatela, D, Tronci, M, Villalta, D., GABUTTI G, GUIDO M, ROTA MC, DE DONNO A, CIOFI DEGLI ATTI ML, CROVARI P, THE SEROEPIDEMIOLOGY GROUP D BASSETTI, A BECHINI, S BOCCALINI, P BONANNI, P CACIAGLI, A CAMPER, AM CAMPA, W CARACCIO, A CAVALLARO, E CIAMARRA, L CLERICO, L CASENTINO, E DE SIMONE, A FAVERO, A FOC A, L GENNA, GIAMMANCO A, A GIANCOTTI, A GOGLIO, S GRANDESSO, GC ICARDI, LOLLI, D MARCHETTI, M MARSELLA, P MARTELLI, L MUCIGNAT, D PALLADINO, C PASSERINI, PERANI, E PISCIONE, F RIZZA, A ZIZZA, L SIMULA, R SFORZA, D TAGLIATATELA, M TRONCI, and AND D VILLALTA

Subjects
Adult, Male, medicine.medical_specialty, Settore MED/07 - Microbiologia E Microbiologia Clinica, Adolescent, Databases, Factual, Mumps, Seroprevalence, Vaccination, Age Factors, Child, Child, Preschool, Disease Outbreaks, Female, Humans, Immunoglobulin G, Infant, Italy, Middle Aged, Registries, Seroepidemiologic Studies, mumps, seroprevalence, vaccination, Serology, Databases, Epidemiology, medicine, Preschool, Factual, General Veterinary, General Immunology and Microbiology, business.industry, Public Health, Environmental and Occupational Health, Italian population, Virology, Mumps, Seroprevalence, Vaccination, Infectious Diseases, Vaccination coverage, Molecular Medicine, Viral disease, business, Demography
Abstract

In Italy, although vaccination has been recommended for a number of years, vaccination coverage for mumps is still sub-optimal. The objective of the present study was to evaluate the seroprevalence of mumps antibodies in the Italian population, stratified by age, gender and geographical area. The proportion of individuals positive for mumps antibodies remained stable in the age classes 0–11 months and 1 year (25.4% and 30.8%, respectively) and showed a continuous increase after the second year of life. The percentage of susceptible individuals was higher than 20% in persons 2–14 years of age and exceeded 10% in persons 15–39 years of age. No statistically significant differences were observed by gender or geographical area. Comparison between these results and the data obtained from a 1996 survey showed a statistically significant increase in seroprevalence in the age class 2–4 years. No changes were observed in the other age-groups. The results of this study confirm that the efforts made in recent years to improve vaccination coverage within the second year of life should be strengthened.

Published
2008

40. Mapping adaptation of barley to Mediterranean environments

Author

Francia, Enrico, Tondelli, A., Barabaschi, Delfina, Rizza, F., Li Destri Nicosia, O., Mastrangelo, A., Di Fonzo, N., and Pecchioni, Nicola

Subjects
resistenza alla siccità, single nucleotide polymorphisms, stress tolerance orzo, geni candidati, SNP, candidate genes, selezione assistita
Published
2004

47. Determinants of barley grain yield in drought-prone Mediterranean environments

Author

Francia, E., Tondelli, A., Rizza, F., Badeck, F.W., Thomas, W.T.B., van Eeuwijk, F., Romagosa, I., Stanca, A.M., Pecchioni, N., Francia, E., Tondelli, A., Rizza, F., Badeck, F.W., Thomas, W.T.B., van Eeuwijk, F., Romagosa, I., Stanca, A.M., and Pecchioni, N.

Abstract

The determinants of barley grain yield in drought-prone Mediterranean environments have been studied in the Nure x Tremois (NT) population. A large set of yield and other morpho-physiological data were recorded in 118 doubled-haploid lines of the population, in multi-environment field trials (18 site-year combination). Agrometeorological variables have been recorded and calculated at each site too. Four main periods of barley development were considered, vegetative, reproductive early and late grain filling phases, to dissect the effect on yield traits of the growth phases. Relationships between agrometeorological variables, grain yield (GY) and its main components (GN and GW) were also investigated by correlation. Results firstly gave a clear indication of the involvement of water consumption in determining GY and GW (r2=0.616, P=0.007 and r2=0.703, P=0.005, respectively) calculated from sowing to the early grain filling period, while GN showed its highest correlation with the total photothermal quotient (PQ) calculated for the same period (r2=0.646, P=0.013). With the only exception of total PQ calculated during the vegetative period, all significant correlations with GY were associated to water-dependent agrometeorological parameters. As a second result, the NT segregating population allowed us to weight the amount of interaction due to genotypes over environments or to environments in relation to genotypes by a GGE analysis; 47.67% of G+GE sum of squares was explained by the first two principal components. Then, the introduction of genomic information at major barley genes regulating the length of growth cycle allowed us to explain patterns of adaptation of different groups of NT lines according to the variants (alleles) harbored at venalization (Vrn-H1) in combination with earliness (Eam6) genes. The superiority of the lines carrying the Nure allele at Eam6 was confirmed by factorial ANOVA testing the four possible haplotypes obtained combining alternative alle

Published
2013

48. Proficiency testing of first- and second-line anti-tuberculosis drugs in Italy

Author

Fattorini, Lanfranco, Migliori, Giovanni Battista, Cassone, Antonio, Alessandromustazzolu, Null, Piccaro, Giovanni, Filippini, Perla, Cirillo, Danielamaria, Borroni, Emanuele, Piersimoni, C., Costa, Damiano, Grimaldi, Anna, De Santis, A., Arosio, M., Goglio, A., Mazza, C., Squintani, L., Di Pede, B., Gaspari, Giulia, Marchetti, Daniela, Nanetti, A., Larcher, C., Frizzera, Eliana, Rizza, F., Pinsi, G., Turano, A., Caddeu, R., Farris, A. G., Di Naso, C., Cavalcanti, Pietro, Tomei, G., Mantini, Giovanna, Ceruti, T., Ferrari, L., Rossi, M. R., Tortoli, E., Montini, G., Senno, E., Nistico', Salvatore, Colonna, C., Buono, L., Mazzola, Elena, Gesu, G., Penati, Valentina, Vaccarino, P., Piana, Federica, Cichero, P., Lombardi, A., Mantovani, Dario Giuseppe, Fabio, A., Bertoli, Giuseppe, Rumpianesi, F., Santoro, G., Molinari, G. L., Camaggi, A., Chirillo, M. G., Peracchi, M., Fallico, L., Menozzi, M., Dettori, G., Marone, P., Bono, L., Mazzolla, R., Sposini, T., Tiecco, C., Barbaro, A., Vecchia, Pier Luigi, Piscina, A., Chiaradonna, P., Tronci, M., Bordi, E., De Mori, P., Diamare, F., Libanori, E., Panaiota, T., Milano, Roberta, Mondo, A., Barbui, A., Fabbro, Lori, Centis, R., D'Ambrosio, L., Spanevello, A., Caola, I., Mottola, Antonella, Fabris, Cristina Angela, Scagnelli, M., Screm, M. C., Scarparo, C., Costa, D., Marchetti, D. (ORCID:0000-0003-0952-4006), Cavalcanti, P., Mantini, G. (ORCID:0000-0001-5303-4499), Nisticò, S., Fabbro, Loris, Fattorini, Lanfranco, Migliori, Giovanni Battista, Cassone, Antonio, Alessandromustazzolu, Null, Piccaro, Giovanni, Filippini, Perla, Cirillo, Danielamaria, Borroni, Emanuele, Piersimoni, C., Costa, Damiano, Grimaldi, Anna, De Santis, A., Arosio, M., Goglio, A., Mazza, C., Squintani, L., Di Pede, B., Gaspari, Giulia, Marchetti, Daniela, Nanetti, A., Larcher, C., Frizzera, Eliana, Rizza, F., Pinsi, G., Turano, A., Caddeu, R., Farris, A. G., Di Naso, C., Cavalcanti, Pietro, Tomei, G., Mantini, Giovanna, Ceruti, T., Ferrari, L., Rossi, M. R., Tortoli, E., Montini, G., Senno, E., Nistico', Salvatore, Colonna, C., Buono, L., Mazzola, Elena, Gesu, G., Penati, Valentina, Vaccarino, P., Piana, Federica, Cichero, P., Lombardi, A., Mantovani, Dario Giuseppe, Fabio, A., Bertoli, Giuseppe, Rumpianesi, F., Santoro, G., Molinari, G. L., Camaggi, A., Chirillo, M. G., Peracchi, M., Fallico, L., Menozzi, M., Dettori, G., Marone, P., Bono, L., Mazzolla, R., Sposini, T., Tiecco, C., Barbaro, A., Vecchia, Pier Luigi, Piscina, A., Chiaradonna, P., Tronci, M., Bordi, E., De Mori, P., Diamare, F., Libanori, E., Panaiota, T., Milano, Roberta, Mondo, A., Barbui, A., Fabbro, Lori, Centis, R., D'Ambrosio, L., Spanevello, A., Caola, I., Mottola, Antonella, Fabris, Cristina Angela, Scagnelli, M., Screm, M. C., Scarparo, C., Costa, D., Marchetti, D. (ORCID:0000-0003-0952-4006), Cavalcanti, P., Mantini, G. (ORCID:0000-0001-5303-4499), Nisticò, S., and Fabbro, Loris

Abstract

N/A

Published
2012

49. Surveillance of anti-tuberculosis drug resistance: Results of the 1998/1999 proficiency testing in Italy

Author

Migliori, Gb, Ambrosetti, M, Fattorini, L, Penati, V, Vaccarino, P, Besozzi, G, Ortona, L, Saltini, C, Orefici, G, Moro, Ml, Iona, E, Cassone, A, De Santis, A, Giorgio, V, Vinciguerra, P, Angarano, G, Petrozzi, L, Costa, D, Gozzellino, F, Perboni, A, Marchetti, D, Pascali, A, Falcone, F, Mariano, V, Rizza, F, Pretto, P, Turano, A, Matteelli, A, Carosi, Gp, Tedoldi, S, Pinsi, G, Farris, Ag, Ligia, Gp, Orani, G, Farris, B, Foschi, C, Trucco, G, Aiolfi, S, Ceruti, T, Parpanesi, M, Calabro, S, Felisatti, G, Tortoli, E, Nutini, S, Montini, G, Fiorentini, F, D'Ambrosio, V, Ceraminiello, A, Bernorio, S, Buono, L, Montesano, P, Vinci, E, Sabato, E, Gamba, S, Crepaldi, P, Bertoli, G, Rupianesi, F, Losi, M, Richeldi, L, Ferrara, G, Muccio, E, Napolitano, G, Molinari, Gl, Saini, L, Garzone, A, Vertuccio, C, Marcias, Menozzi, Marone, P, Peona, Nascimbene, Pasi, Cascina, Casali, Monaco, Penza, Pasticci, M. B., Bistoni, Sposini, Colorizio, Confalonieri, M, Bottrighi, P, Orsi, Schiavi, Macor, Moretti, Fatigante, Barbaro, Agati, Zacarra, Viola, Donne, Le, Farinelli, Mancini, and Ermeti

Subjects
Drug susceptibility testing, Tuberculosis, Proficiency testing
Published
2000

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