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2. Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) scientific statement on the simplification of the drug regimen for secondary cardiovascular prevention

Author

De Luca, Leonardo, Di Fusco, Stefania Angela, Iannopollo, Gianmarco, Mistrulli, Raffaella, Rizzello, Vittoria, Aimo, Alberto, Navazio, Alessandro, Bilato, Claudio, Corda, Marco, Di Marco, Massimo, Geraci, Giovanna, Iacovoni, Attilio, Milli, Massimo, Pascale, Vittorio, Riccio, Carmine, Scicchitano, Pietro, Tizzani, Emanuele, Gabrielli, Domenico, Grimaldi, Massimo, Colivicchi, Furio, and Oliva, Fabrizio

Abstract

The issue of suboptimal drug regimen adherence in secondary cardiovascular prevention presents a significant barrier to improving patient outcomes. To address this, the utilization of drug combinations, specifically single pill combinations (SPCs) and polypills, was proposed as a strategy to simplify treatment regimens. This approach aims to enhance treatment accessibility, affordability, and adherence, thereby reducing healthcare costs and improving patient health. The document is an Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) scientific statement on simplifying drug regimens for secondary cardiovascular prevention. It discusses the underuse of treatments despite available, effective, and accessible options, highlighting a significant gap in secondary prevention across different socio-economic statuses and countries. The statement explores barriers to implementing evidence-based treatments, including patient, healthcare provider, and system-related challenges. The paper also reviews international guidelines, the role of SPCs and polypills in clinical practice, and their economic impact, advocating for their use in secondary prevention to improve patient outcomes and adherence.

Published
2024
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14. Persistent Activation of Nuclear Factor Kappa-B Signaling Pathway in Patients With Unstable Angina and Elevated Levels of C-Reactive Protein: Evidence for a Direct Proinflammatory Effect of Azide and Lipopolysaccharide-Free C-Reactive Protein on Human Monocytes Via Nuclear Factor Kappa-B Activation

Author

Liuzzo, Giovanna, Santamaria, Matteo, Biasucci, Luigi M., Narducci, Michela, Colafrancesco, Valeria, Porto, Annalisa, Brugaletta, Salvatore, Pinnelli, Michela, Rizzello, Vittoria, Maseri, Attilio, and Crea, Filippo

Published
2007
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15. Long-term prediction of mortality in elderly persons by dobutamine stress echocardiography

Author

Biagini, Elena, Elhendy, Abdou, Schinkel, Arend F.L., Rizzello, Vittoria, Bax, Jeroen J., Sozzi, Fabiola B., Kertai, Miklos D., van Domburg, Ron T., Krenning, Boudewijn J., Branzi, Angelo, Rapezzi, Claudio, Simoons, Maarten L., and Poldermans, Don

Subjects
Echocardiography -- Usage, Aged -- Research, Aged -- Patient outcomes, Mortality -- Research, Health, Seniors
Abstract

Background. Dobutamine stress echocardiography (DSE) was shown to provide incremental prognostic information. However, its role in the prediction of mortality in elderly persons is not well defined. We assessed the value of DSE in the prediction of mortality and hard cardiac events during long-term follow-up in patients older than 65 years. Methods. We studied 1434 patients >65 years old (mean age 72 [+ or -] 3 years) who underwent DSE for evaluation of coronary artery disease. Ischemia was defined as new or worsening wall motion abnormalities. Follow-up events were total mortality and hard cardiac events (cardiac mortality and nonfatal myocardial infarction). Multivariable Cox regression analysis was used to identify the independent predictors of follow-up events. Results. Ischemia was detected in 675 patients (47%). Five hundred six patients (35%) had a normal study, and 253 (18%) had fixed wall motion abnormalities. During a mean follow-up of 6.5 years, 532 (37%) deaths occurred, of which 249 (17%) were due to cardiac causes. A nonfatal myocardial infarction occurred in 45 patients (3%). Independent predictors of all-cause mortality in a multivariate analysis model were age (hazard ratio [HR] 1.06; 95% confidence interval [CI], 1.05-1.08), male sex (HR 1.5; 95% CI, 1.2-1.8), hypertension (HR 1.2; 95% CI, 1.1-1.4), smoking (HR 1.3; 95% CI, 1.1-1.6), diabetes (HR 1.4; 95% CI, 1.1-1.8), rest wall motion abnormalities (HR 1.07; 95% CI, 1.06-1.09), and ischemia (HR 1.3; 95% CI, 1.1-1.6). Independent predictors of hard cardiac events were age (HR 1.07; 95% CI, 1.05-1.09), male sex (HR 1.3; 95% CI, 1.1-1.7), smoking (HR 1.3; 95% CI, 1.1-1.6), diabetes (HR 1.6; 95% CI, 1.2-2.2), rest wall motion abnormalities (HR 1.13; 95% CI, 1.12-1.16), and ischemia (HR 2.1; 95% CI, 1.5-2.8). Conclusion. DSE provides independent prognostic information to predict all-cause mortality and hard cardiac events in elderly patients.

Published
2005

20. Paradoxical preservation of vascular function in severe obesity

Author

Biasucci, Luigi Marzio, Graziani, Francesca, Rizzello, Vittoria, Liuzzo, Giovanna, Guidone, Caterina, De Caterina, Alberto Ranieri, Brugaletta, Salvatore, Mingrone, Gertrude, and Crea, Filippo

Subjects
Obesity -- Complications and side effects, Obesity -- Research, Coronary heart disease -- Patient outcomes, Coronary heart disease -- Risk factors, Coronary heart disease -- Research, Inflammation -- Research, Inflammation -- Risk factors, Health, Health care industry
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2010.02.016 Byline: Luigi Marzio Biasucci (a), Francesca Graziani (a), Vittoria Rizzello (a), Giovanna Liuzzo (a), Caterina Guidone (b), Alberto Ranieri De Caterina (a), Salvatore Brugaletta (a), Gertrude Mingrone (b), Filippo Crea (a) Keywords: Endothelial function; Inflammation; Obesity Abstract: Obesity is associated with a high risk of coronary artery disease morbidity and mortality. Yet, postmortem studies have shown that severely obese subjects exhibit smooth coronary arteries, thus suggesting that they may be protected from atherosclerosis. We assessed vascular function and its possible determinants in a cohort of normal-weight to severely obese insulin-sensitive subjects (body mass index [BMI] 23.2-49 kg/m.sup.2). Author Affiliation: (a) Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy (b) Institute of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy Article Note: (footnote) Funding: The study was funded by grant 70200400 from Catholic University of the Sacred Heart, Rome, Italy., Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript., Authorship: All authors had access to the data and played a role in writing this manuscript.

Published
2010

30. Chronic aspirin and statin therapy in patients with impaired renal function and acute coronary syndromes: results from the IN-ACS Outcome Registry

Author

Sciahbasi, Alessandro, primary, Rizzello, Vittoria, additional, Gonzini, Lucio, additional, Giampaoli, Simona, additional, Greco, Cesare, additional, Di Pasquale, Giuseppe, additional, Mureddu, Gian Francesco, additional, Di Chiara, Antonio, additional, Lioy, Ernesto, additional, and Boccanelli, Alessandro, additional

Published
2012
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32. Role of the CD14 C(−260)T promoter polymorphism in determining the first clinical manifestation of coronary artery disease

Author

Rizzello, Vittoria, primary, Liuzzo, Giovanna, additional, Trabetti, Elisabetta, additional, Di Giannuario, Giovanna, additional, Brugaletta, Salvatore, additional, Santamaria, Matteo, additional, Piro, Maddalena, additional, Boccanelli, Alessandro, additional, Pignatti, Pier Franco, additional, Biasucci, Luigi M, additional, and Crea, Filippo, additional

Published
2010
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37. 1059G/C polymorphism within the exon 2 of the C-reactive protein gene: relationship to C-reactive protein levels and prognosis in unstable angina

Author

Rizzello, Vittoria, primary, Liuzzo, Giovanna, additional, Giannuario, Giovanna Di, additional, Trabetti, Elisabetta, additional, Brugaletta, Salvatore, additional, Santamaria, Matteo, additional, Piro, Maddalena, additional, Pignatti, Pier Franco, additional, Maseri, Attilio, additional, Biasucci, Luigi M., additional, and Crea, Filippo, additional

Published
2007
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43. Pacemaker stress echocardiography predicts cardiac events in patients with permanent pacemaker

Author

Biagini, Elena, primary, Schinkel, Arend F.L., additional, Elhendy, Abdou, additional, Bax, Jeroen J., additional, Rizzello, Vittoria, additional, van Domburg, Ron T., additional, Krenning, Boudewijn J., additional, Schouten, Olaf, additional, Branzi, Angelo, additional, Rocchi, Guido, additional, Simoons, Maarten L., additional, and Poldermans, Don, additional

Published
2005
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45. Relation of Improvement in Left Ventricular Ejection Fraction Versus Improvement in Heart Failure Symptoms After Coronary Revascularization in Patients With Ischemic Cardiomyopathy

Author

Rizzello, Vittoria, primary, Poldermans, Don, additional, Biagini, Elena, additional, Schinkel, Arend F.L., additional, Elhendy, Abdou, additional, Leone, Antonio Maria, additional, Crea, Filippo, additional, Maat, Alexander, additional, Roelandt, Jos R.T.C., additional, and Bax, Jeroen J., additional

Published
2005
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47. Myocardial Technetium-99m-Tetrofosmin Single-Photon Emission Computed Tomography Compared With 18F-Fluorodeoxyglucose Imaging to Assess Myocardial Viability

Author

Schinkel, Arend F.L., primary, Bax, Jeroen J., additional, Biagini, Elena, additional, Elhendy, Abdou, additional, van Domburg, Ron T., additional, Valkema, Roelf, additional, Rizzello, Vittoria, additional, Schouten, Olaf, additional, Simoons, Maarten, additional, and Poldermans, Don, additional

Published
2005
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49. Comparison of All-Cause Mortality in Women With Known or Suspected Coronary Artery Disease Referred for Dobutamine Stress Echocardiography With Normal Versus Abnormal Test Results

Author

Biagini, Elena, primary, Elhendy, Abdou, additional, Schinkel, Arend F.L., additional, Rizzello, Vittoria, additional, van Domburg, Ron T., additional, Krenning, Boudewijn J., additional, Schouten, Olaf, additional, Sozzi, Fabiola B., additional, Branzi, Angelo, additional, Rocchi, Guido, additional, Simoons, Maarten L., additional, Bax, Jeroen J., additional, and Poldermans, Don, additional

Published
2005
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50. Seven-year follow-up after dobutamine stress echocardiography

Author

Biagini, Elena, primary, Elhendy, Abdou, additional, Bax, Jeroen J., additional, Rizzello, Vittoria, additional, Schinkel, Arend F.L., additional, van Domburg, Ron T., additional, Kertai, Miklos D., additional, Krenning, Boudewijn J., additional, Bountioukos, Manolis, additional, Rapezzi, Claudio, additional, Branzi, Angelo, additional, Simoons, Maarten L., additional, and Poldermans, Don, additional

Published
2005
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