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1. Contributors

Author

Agabiti-Rosei, Claudia, primary, Agabiti-Rosei, Enrico, additional, Agnoletti, Davide, additional, Alastruey, Jordi, additional, AlGhatrif, Majd, additional, Almada, Horacio, additional, Ángela, Sardella, additional, Argyris, Antonios, additional, Aristizabal, Dagnovar, additional, Armeni, Eleni, additional, Avolio, Alberto, additional, Badariene, Jolita, additional, Badhwar, Smriti, additional, Barbosa, Eduardo Costa Duarte, additional, Barroso, Weimar Kunz Sebba, additional, Bascetin, Rümeyza, additional, Baynard, Tracy, additional, Becerra, Carlos Ramos, additional, Bennett, Nadia, additional, Bianchini, Elisabetta, additional, Bohn, Lucimere, additional, Borghi, Claudio, additional, Bortolotto, Luiz Aparecido, additional, Boutouyrie, Pierre, additional, Bruno, Rosa Maria, additional, Burnier, Michel, additional, Butlin, Mark, additional, Calabria, Fabiana, additional, Camafort, Miguel, additional, Cavero-Redondo, Iván, additional, Challande, Pascal, additional, Chirinos, Julio A., additional, Climie, Rachel Emma, additional, Cockcroft, John, additional, Cotter, Jorge, additional, Cruickshank, J. Kennedy, additional, Cunha, Pedro Guimarães, additional, Damianaki, Aikaterini, additional, De Backer, Tine, additional, De Buyzere, Marc L., additional, De Caterina, Raffaele, additional, De Ciuceis, Carolina, additional, Debette, Stephanie, additional, Edsfeldt, Andreas, additional, Fernhall, Bo, additional, Ferreira, Isabel, additional, Fisher, Simon, additional, Forcada, Pedro, additional, S. Franklin, Stanley, additional, Garcia, Ricardo, additional, Georgiopoulos, Georgios, additional, Ghiadoni, Lorenzo, additional, Goncalves, Isabel, additional, Gottsäter, Mikael, additional, Graham, Delyth, additional, Greene, Katherine, additional, Guala, Andrea, additional, Hametner, Bernhard, additional, Hashimoto, Junichiro, additional, Hering, Dagmara, additional, Hibner, Brooks A., additional, Højlund, Kurt, additional, Hughes, Alun, additional, Ikonomidis, Ignatios, additional, Johansson, Madeleine, additional, Jordan, Jens, additional, Kario, Kazuomi, additional, Kotsis, Vasilios, additional, Kozakova, Michaela, additional, Lacolley, Patrick, additional, Lagrange, Jérémy, additional, Lakatta, Edward G., additional, Lambrinoudaki, Irene, additional, Laucyte-Cibulskiene, Agne, additional, Laurent, Stéphane, additional, Lopes, Wendell Arthur, additional, Lopez-Jaramillo, Patricio, additional, Magalhaes, Lucélia Batista Neves Cunha, additional, Magnussen, Costan G., additional, Mavraganis, Georgios, additional, Mayer, Christopher Clemens, additional, Maynard, Hannah, additional, McBride, Martin W., additional, McDonnell, Barry J., additional, McEniery, Carmel M., additional, Mota, Jorge, additional, Motl, Robert W., additional, Mozos, Ioana, additional, Muiesan, Maria Lorenza, additional, Muñoz, Ernesto Cardona, additional, Narkiewicz, Krzysztof, additional, Nemcsik, János, additional, Neves, Mario Fritsch, additional, Nilsson, Jan, additional, Nilsson, Peter M., additional, Oberhoffer-Fritz, Renate, additional, Ochoa, Juan Eugenio, additional, Okawa, Jaqueline Lyrio Bermudes, additional, Okawa, Rogério Toshiro Passos, additional, Olesen, Thomas Bastholm, additional, Oliveira, José, additional, Oliveras, Anna, additional, Hecht Olsen, Michael, additional, Ortiz, Luis Garcia, additional, Pahkala, Katja, additional, Paini, Anna, additional, Palombo, Carlo, additional, Parati, Gianfranco, additional, Park, Chloe, additional, Pavlidis, George, additional, Piani, Federica, additional, Pierce, Gary L., additional, Pizzala, Pablo G., additional, Protogerou, Athanase D., additional, Pucci, Giacomo, additional, Pupi, Luis María, additional, Pupi, Pablo María, additional, Raitakari, Olli T., additional, Rajkumar, C., additional, Ramirez, Agustín, additional, Raso, Francesco Mattace, additional, Recchia, Fabio Anastasio, additional, Regnault, Veronique, additional, Rietzschel, Ernst, additional, Rizzoni, Damiano, additional, Rodilla, Enrique, additional, Rovio, Suvi P., additional, Ryliskyte, Ligita, additional, Salvi, Paolo, additional, Sanchez, Ramiro, additional, Sáry, Javier Osvaldo, additional, Schillaci, Giuseppe, additional, Schmidt-Trucksäss, Arno, additional, Scuteri, Angelo, additional, Segers, Patrick, additional, Sharman, James, additional, Sierra, Cristina, additional, Stamatelopoulos, Kimon, additional, Steckelings, Ulrike M., additional, Stehouwer, Coen D.A., additional, Stoner, Lee, additional, Taddei, Stefano, additional, Terentes-Printzios, Dimitrios, additional, Tomiyama, Hirofumi, additional, Trivett, Cara, additional, Tsioufis, Costas, additional, Turroni, Silvia, additional, Urbina, Elaine M., additional, Van Bortel, L., additional, van de Laar, Roel J., additional, van der Heide, Frank C.T., additional, Vázquez, Susana, additional, Vishram-Nielsen, Julie, additional, Vlachopoulos, Charalambos, additional, Vlastos, Dimitrios, additional, Walker, Ashley, additional, Wang, Mingyi, additional, Weber, Thomas, additional, Xaplanteris, Panagiotis, additional, Zanoli, Luca, additional, and Zhou, Manshi, additional

Published
2024
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5. Diabetes and Microcirculation

Author

Rizzoni, Damiano, Agabiti-Rosei, Claudia, De Ciuceis, Carolina, Rosei, Agabiti, Mancia, Giuseppe, Series Editor, Agabiti Rosei, Enrico, Series Editor, and Berbari, Adel E., editor

Published
2023
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10. Comparison of the characteristics, morbidity and mortality of COVID-19 between first and second/third wave in a hospital setting in Lombardy: a retrospective cohort study

Author

Leidi, Francesca, Boari, Gianluca Edoardo Mario, Scarano, Ottavio, Mangili, Benedetta, Gorla, Giulia, Corbani, Andrea, Accordini, Beatrice, Napoli, Federico, Ghidelli, Chiara, Archenti, Giulia, Turini, Daniele, Saottini, Michele, Guarinoni, Vittoria, Ferrari-Toninelli, Giulia, Manzoni, Francesca, Bonetti, Silvia, Chiarini, Giulia, Malerba, Paolo, Braglia-Orlandini, Federico, Bianco, Gianluca, Faustini, Cristina, Agabiti-Rosei, Claudia, De Ciuceis, Carolina, and Rizzoni, Damiano

Published
2022
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12. RETINAL MICROVASCULAR ALTERATIONS IN PATIENTS WITH ERECTILE DYSFUNCTION

Author

Lemoli, Matteo, primary, Rosei, Claudia Agabiti, additional, Rossini, Claudia, additional, Delbarba, Andrea, additional, Laera, Nicola, additional, Facondo, Paolo, additional, Nardin, Matteo, additional, Malerba, Paolo, additional, Baresi, Mattia, additional, Leidi, Francesca, additional, Porteri, Enzo, additional, Rizzoni, Damiano, additional, Ferlin, Alberto, additional, and De Ciuceis, Carolina, additional

Published
2024
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13. RETINAL MICROVASCULAR ASSESSMENT IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES

Author

De Ciuceis, Carolina, primary, Famà, Francesca, additional, Rosei, Claudia Agabiti, additional, Zammarchi, Irene, additional, Salvotti, Francesca, additional, Petroboni, Beatrice, additional, Rossini, Claudia, additional, Lemoli, Matteo, additional, Bevacqua, Cristina, additional, Cattaneo, Chiara, additional, Sinaimeri, Gerta, additional, Buso, Giacomo, additional, Porteri, Enzo, additional, Rizzoni, Damiano, additional, Ricci, Chiara, additional, and Muiesan, Maria Lorenza, additional

Published
2024
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17. Retinal microvascular alterations in patients with active rheumatoid arthritis without cardiovascular risk factors: the potential effects of T cell co-stimulation blockade

Author

Piantoni, Silvia, primary, Regola, Francesca, additional, Angeli, Fabrizio, additional, Caproli, Alessia, additional, Trovati, Annalisa, additional, Tomasi, Cesare, additional, Chiarini, Giulia, additional, Rossini, Claudia, additional, Rosei, Claudia Agabiti, additional, De Ciuceis, Carolina, additional, Franceschini, Franco, additional, Muiesan, Maria Lorenza, additional, Rizzoni, Damiano, additional, and Airò, Paolo, additional

Published
2024
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18. Organ Damage

Author

Agabiti Rosei, Enrico, Rizzoni, Damiano, Agabiti-Rosei, Claudia, Paini, Anna, Muiesan, Maria Lorenza, Mancia, Giuseppe, Series Editor, Agabiti Rosei, Enrico, Series Editor, Morganti, Alberto, editor, and Mantero, Franco, editor

Published
2020
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23. Early use of low dose tocilizumab in patients with COVID-19: A retrospective cohort study with a complete follow-up

Author

De Rossi, Nicola, Scarpazza, Cristina, Filippini, Chiara, Cordioli, Cinzia, Rasia, Sarah, Mancinelli, Chiara Rosa, Rizzoni, Damiano, Romanelli, Giuseppe, Cossi, Stefania, Vettoretto, Nereo, Bove, Sergio, Manfredini, Silvano, Beindorf, Eva Andrea, Mosca, Carlo, Scipione, Vittorio, Flamminio, Gigliola, Albini, Elena Albini, Giansiracusa, Paola, and Capra, Ruggero

Published
2020
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24. The 2020 Italian Society of Arterial Hypertension (SIIA) practical guidelines for the management of primary aldosteronism

Author

Rossi, Gian Paolo, Bisogni, Valeria, Bacca, Alessandra Violet, Belfiore, Anna, Cesari, Maurizio, Concistrè, Antonio, Del Pinto, Rita, Fabris, Bruno, Fallo, Francesco, Fava, Cristiano, Ferri, Claudio, Giacchetti, Gilberta, Grassi, Guido, Letizia, Claudio, Maccario, Mauro, Mallamaci, Francesca, Maiolino, Giuseppe, Manfellotto, Dario, Minuz, Pietro, Monticone, Silvia, Morganti, Alberto, Muiesan, Maria Lorenza, Mulatero, Paolo, Negro, Aurelio, Parati, Gianfranco, Pengo, Martino F., Petramala, Luigi, Pizzolo, Francesca, Rizzoni, Damiano, Rossitto, Giacomo, Veglio, Franco, and Seccia, Teresa Maria

Published
2020
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27. Long-term impact of COVID-19 requiring elevated oxygen support and safety of prolonged positive pressure ventilation

Author

Salvotti, Francesca, primary, Pellegrinelli, Riccardo, additional, Geroldi, Veronica, additional, Leidi, Francesca, additional, Scipione, Vittorio, additional, Flamminio, Gigliola, additional, Pastori, Antonella, additional, Agabiti-Rosei, Claudia, additional, De Ciuceis, Carolina, additional, Rizzoni, Damiano, additional, and Boari, Gianluca Edoardo Mario, additional

Published
2023
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28. Prognostic significance of the wall to lumen ratio of retinal arterioles evaluated by adaptive optics in humans

Author

De Ciuceis, Carolina, primary, Rosei, Claudia Agabiti, additional, Malerba, Paolo, additional, Rossini, Claudia, additional, Nardin, Matteo, additional, Chiarini, Giulia, additional, Famà, Francesca, additional, Lemoli, Matteo, additional, Baresi, Mattia, additional, Petelca, Alina, additional, Bortoluzzi, Chiara, additional, Porteri, Enzo, additional, Salvetti, Massimo, additional, Muiesan, Maria Lorenza, additional, Rosei, Enrico Agabiti, additional, and Rizzoni, Damiano, additional

Published
2023
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32. Influence of Perivascular Adipose Tissue on Microcirculation: A Link Between Hypertension and Obesity.

Author

Agabiti-Rosei, Claudia, Saxton, Sophie N., De Ciuceis, Carolina, Muiesan, Maria Lorenza, Rizzoni, Damiano, Agabiti Rosei, Enrico, and Heagerty, Anthony M.

Abstract

Alterations in microcirculation play a crucial role in the pathogenesis of cardiovascular and metabolic disorders such as obesity and hypertension. The small resistance arteries of these patients show a typical remodeling, as indicated by an increase of media or total wall thickness to lumen diameter ratio that impairs organ flow reserve. The majority of blood vessels are surrounded by a fat depot which is termed perivascular adipose tissue (PVAT). In recent years, data from several studies have indicated that PVAT is an endocrine organ that can produce a variety of adipokines and cytokines, which may participate in the regulation of vascular tone, and the secretory profile varies with adipocyte phenotype and disease status. The PVAT of lean humans largely secretes the vasodilator adiponectin, which will act in a paracrine fashion to reduce peripheral resistance and improve nutrient uptake into tissues, thereby protecting against the development of hypertension and diabetes. In obesity, PVAT becomes enlarged and inflamed, and the bioavailability of adiponectin is reduced. The inevitable consequence is a rise in peripheral resistance with higher blood pressure. The interrelationship between obesity and hypertension could be explained, at least in part, by a cross-talk between microcirculation and PVAT. In this article, we propose an integrated pathophysiological approach of this relationship, in order to better clarify its role in obesity and hypertension, as the basis for effective and specific prevention and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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34. The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Author

Mengozzi, Alessandro, primary, de Ciuceis, Carolina, additional, Dell’oro, Raffaella, additional, Georgiopoulos, Georgios, additional, Lazaridis, Antonios, additional, Nosalski, Ryszard, additional, Pavlidis, George, additional, Tual-Chalot, Simon, additional, Agabiti-Rosei, Claudia, additional, Anyfanti, Panagiota, additional, Camargo, Livia L., additional, Dąbrowska, Edyta, additional, Quarti-Trevano, Fosca, additional, Hellmann, Marcin, additional, Masi, Stefano, additional, Mavraganis, Georgios, additional, Montezano, Augusto C., additional, Rios, Francesco J., additional, Winklewski, Pawel J., additional, Wolf, Jacek, additional, Costantino, Sarah, additional, Gkaliagkousi, Eugenia, additional, Grassi, Guido, additional, Guzik, Tomasz J., additional, Ikonomidis, Ignatios, additional, Narkiewicz, Krzysztof, additional, Paneni, Francesco, additional, Rizzoni, Damiano, additional, Stamatelopoulos, Kimon, additional, Stellos, Konstantinos, additional, Taddei, Stefano, additional, Touyz, Rhian M., additional, Triantafyllou, Areti, additional, and Virdis, Agostino, additional

Published
2023
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35. PROGNOSTIC SIGNIFICANCE OF THE WALL TO LUMEN RATIO OF RETINAL ARTERIOLES EVALUATED BY ADAPTIVE OPTICS IN HUMAN HYPERTENSION

Author

Ciuceis, Carolina De, primary, Rosei, Claudia Agabiti, additional, Malerba, Paolo, additional, Brami, Valeria, additional, Chiarini, Giulia, additional, Fama’, Francesca, additional, Rossini, Claudia, additional, Gaggero, Andrea, additional, Lemoli, Matteo, additional, Nardin, Matteo, additional, Petelca, Alina, additional, Bortoluzzi, Chiara, additional, Baresi, Mattia, additional, Porteri, Enzo, additional, Muiesan, Maria Lorenza, additional, Rosei, Enrico Agabiti, additional, and Rizzoni, Damiano, additional

Published
2023
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36. ONGOING ANTI-HYPERTENSIVE TREATMENT DOESN’T IMPACT ON OUTCOME ON MEDIUM-LONG TERM SEQUELAE OF PATIENTS WITH MODERATE TO SEVERE COVID-19 PNEUMONIA

Author

Cattaneo, Chiara, primary, Salvotti, Francesca, additional, Leidi, Francesca, additional, Pellegrinelli, Riccardo, additional, Geroldi, Veronica, additional, Loro, Giorgia, additional, Reale, Scilla, additional, Vaccarello, Paola, additional, Cherubini, Fabio, additional, Borghi, Erika, additional, Napoli, Federico, additional, Malerba, Paolo, additional, Ciuceis, Carolina De, additional, Rosei, Claudia Agabiti, additional, Rizzoni, Damiano, additional, and Boari, Gianluca E.M., additional

Published
2023
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37. Organ Damage

Author

Agabiti Rosei, Enrico, primary, Rizzoni, Damiano, additional, Agabiti-Rosei, Claudia, additional, Paini, Anna, additional, and Muiesan, Maria Lorenza, additional

Published
2020
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38. Challenges in the evaluation of endothelial cell dysfunction: a statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors

Author

Rossi, Gian Paolo, Barton, Matthias, Dhaun, Neeraj, Rizzoni, Damiano, and Seccia, Teresa M

Subjects
kidney, hypertension, endothelium, Physiology, blood pressure, arterial, endothelial dysfunction, blood vessels, atherosclerosis, chronic kidney disease, miRNA, Internal Medicine, Cardiology and Cardiovascular Medicine
Published
2022

40. The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Author

Mengozzi, Alessandro, de Ciuceis, Carolina, Dell'oro, Raffaella, Georgiopoulos, Georgios, Lazaridis, Antonios, Nosalski, Ryszard, Pavlidis, George, Tual-Chalot, Simon, Agabiti-Rosei, Claudia, Anyfanti, Panagiota, Camargo, Livia L, Dąbrowska, Edyta, Quarti-Trevano, Fosca, Hellmann, Marcin, Masi, Stefano, Mavraganis, Georgios, Montezano, Augusto C, Rios, Francesco J, Winklewski, Pawel J, Wolf, Jacek, Costantino, Sarah, Gkaliagkousi, Eugenia, Grassi, Guido, Guzik, Tomasz J, Ikonomidis, Ignatios, Narkiewicz, Krzysztof, Paneni, Francesco, Rizzoni, Damiano, Stamatelopoulos, Kimon, Stellos, Konstantinos, Taddei, Stefano, Touyz, Rhian M, Triantafyllou, Areti, and Virdis, Agostino

Abstract

Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted by environmental stressors and consequently involved in the development and progression of ageing and age-related disease. Microvascular dysfunction, if not targeted, leads to a steady derangement of the phenotype, which cumulates comorbidities and eventually results in a nonrescuable, very high-cardiovascular risk. Along the broad spectrum of pathologies, both shared and distinct molecular pathways and pathophysiological alteration are involved in the disruption of microvascular homeostasis, all pointing to microvascular inflammation as the putative primary culprit. This position paper explores the presence and the detrimental contribution of microvascular inflammation across the whole spectrum of chronic age-related diseases, which characterise the 21st-century healthcare landscape. The manuscript aims to strongly affirm the centrality of microvascular inflammation by recapitulating the current evidence and providing a clear synoptic view of the whole cardiometabolic derangement. Indeed, there is an urgent need for further mechanistic exploration to identify clear, very early or disease-specific molecular targets to provide an effective therapeutic strategy against the otherwise unstoppable rising prevalence of age-related diseases.

Published
2023

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