1. Patterns of adjuvant treatment and survival outcomes in stage I uterine carcinosarcoma
- Author
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Lori Cory, Colleen Brensinger, Robert A. Burger, Robert L. Giuntoli, II, Mark A. Morgan, Nawar Latif, Lilie L. Lin, and Emily M. Ko
- Subjects
stage I uterine carcinosarcoma ,Early stage ,Endometrial cancer ,Adjuvant therapy ,Radiation ,Chemotherapy ,Gynecology and obstetrics ,RG1-991 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective: To determine patterns in type and sequence of adjuvant treatment and associated differences in overall survival among women with Stage I uterine carcinosarcoma (UCS). Methods: Women with stage I UCS from 2000 to 2015 were identified through the National Cancer Institute’s Surveillance, Epidemiology and End Results database linked to Medicare-based claims follow-up data through 2016. Data including demographics, co-morbidities, surgical procedure, surgical pathology and type and sequence of adjuvant treatment were collected. The primary study outcome was overall survival (OS) by type and sequence of adjuvant therapy. Cancer specific survival was also analyzed. Results: A total of 755 women with Stage I UCS were identified. Of these, 56.3% (n = 445) received adjuvant therapy, whereas 43.7% (n = 330) did not. In comparison to no adjuvant treatment, an overall survival benefit was noted with receipt of chemotherapy alone for women with Stage I disease (log rank p 0.05 for all). Likewise, radiation alone and no treatment were associated with worse OS compared to chemotherapy alone (p
- Published
- 2022
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