1. Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
- Author
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Montserrat Muñoz, Amanda Cano, M. Pujol, Josefina Prat, Elena Sánchez-López, Eliana B. Souto, Maria Luisa García, Marta Espina, Robert Gironés Petit, A. Ortiz, Patrícia Severino, Universidade do Minho, Fundação para a Ciência e a Tecnologia (Portugal), and European Commission
- Subjects
0301 basic medicine ,QH301-705.5 ,Skin inflammatory diseases ,Dermatitis ,Review ,Disease ,Bioinformatics ,Models, Biological ,Catalysis ,Inorganic Chemistry ,Pathogenesis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Clinical trials ,Psoriasis ,medicine ,Genetic predisposition ,Animals ,Humans ,Nanotechnology ,Physical and Theoretical Chemistry ,Biology (General) ,Molecular Biology ,QD1-999 ,Spectroscopy ,Psoriasis versus atopic dermatitis ,Psoriasi ,Clinical Trials as Topic ,Biodegradable nanoparticles ,Science & Technology ,business.industry ,Organic Chemistry ,General Medicine ,Effective drug concentration ,medicine.disease ,3. Good health ,Computer Science Applications ,Clinical trial ,Skin diseases ,Chemistry ,Nanomedicine ,030104 developmental biology ,Innovative Therapies ,Malalties de la pell ,Drug delivery ,business ,Microneedles - Abstract
Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases., This research was funded by the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE), under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020, granted to EBS., info:eu-repo/semantics/publishedVersion
- Published
- 2021