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O shunt portossistêmico congênito extra-hepático é uma anomalia vascular que consiste na comunicação entre a circulação portal e a sistêmica, fazendo com que substâncias normalmente metabolizadas e excretadas pelo fígado sejam desviadas diretamente para a circulação sistêmica e desencadeiem alterações nos sistemas neurológico, gastrointestinal e urinário. O diagnóstico se dá através de exames de imagem, como ultrassonografia e tomografia computadorizada. Para estabilização do paciente, é muito indicado o tratamento clínico inicial, especialmente para os que manifestam sinais de encefalopatia hepática, e o tratamento definitivo é a atenuação cirúrgica gradual. As técnicas mais indicadas atualmente para a oclusão do shunt são o anel constritor ameróide e a banda de celofane, os quais têm bons resultados a longo prazo. O prognóstico dos pacientes submetidos ao procedimento cirúrgico varia de acordo com o estado geral do paciente no momento do diagnóstico e as complicações que podem ocorrer no trans e pós-operatório, como hipertensão portal, convulsões, hipoglicemia e falha no fechamento do shunt. Este trabalho tem como objetivo relatar um caso de atenuação cirúrgica de shunt gastrocaval direito extra-hepático utilizando a técnica com banda de celofane. O paciente canino, Pug, com oito meses de idade, foi atendido no Hospital Veterinário da Universidade Federal do Paraná apresentando sinais clínicos neurológicos e com diagnóstico prévio de shunt portossistêmico. Para determinar a origem do vaso anômalo e otimizar o planejamento cirúrgico, foi indicada angiotomografia computadorizada. O tratamento clínico foi instituído e, após 15 dias, foi performada a atenuação cirúrgica do shunt utilizando a banda de celofane fixada com clipes de titânio. O paciente apresentou sinais de hipertensão portal, ascite e hipoglicemia pós-operatórias, as quais foram tratadas no período de internação. Após 15 dias da alta hospitalar, o paciente retornou ao Hospital Veterinário com bom estado geral, ausência de ascite e sinais neurológicos e não foram evidenciadas alterações significativas nos exames laboratoriais, demonstrando a eficácia da técnica cirúrgica escolhida.

Background : The thrombotic aortic disease in dogs and cats is characterized by the pathological formation of blood clots that can rupture and obstruct the blood flow. Abdominal ultrasonography can identify the location and extension of thrombus in the main vasculature and using the doppler it is possible to observe the blood flow around the thrombus. Stents are expandable tube-shaped endoprosthesis characterized as a metal mesh and used to prevent or repair stenoses, allowing liquid, gas, or solids to flow. This report aims to describe the surgical and medical treatment of aortic thrombotic disease followed by coronary stents placement in a bitch. Case : An 8-year-old Shih Tzu bitch, presented for evaluation of a 1-month progressive hind limbs paresis. Nociception was present in both limbs, but the patient presented discomfort and vocalization when manipulating the pelvic limbs. A complete blood count demonstrated anemia, mild neutrophilia, and lymphopenia. Serum biochemistry found an increase in ALT, ALP, blood urea nitrogen, and CK. Abdominal ultrasonography detected mild bulging of the caudal aorta and trifurcation of the iliac arteries. Increased intraluminal echogenicity and absence of blood flow were also detected using duplex doppler. The initial medical treatment was ineffective in improving clinical signs, therefore surgical repair was performed. The aorta was isolated and clamped with Satinsky forceps and incised. The thrombus fragmented during removal. A non-compliant high-pressure balloon was used to dilated and remove small fragments of blood clots from the right and left external iliac arteries. Coronary stents of 32 mm length by 2.75 mm diameter were placed to keep both iliac arteries free. Immediately after the procedure, there was a detectable distal pulse in both hind limbs. Despite intensive medical treatment, the patient evolved to respiratory distress and died on the sixth day after surgery. At necropsy, there were thrombi in the lumen of the arteries and several organs in addition to a large hyaline thrombus occluding 80-90% of the aortic lumen and left femoral artery. In the trifurcation region, clots were present, and stents placed in the iliac arteries were also occluded. Discussion : The occurrence of aortic and iliac thrombosis is associated with several conditions, including neoplasia, chronic kidney disease, heart failure, gastric dilatation-volvulus, hypothyroidism, and hyperadrenocorticism (HAC). In this case, the underlying cause of thromboembolism was supposed to be related to an endocrine condition, since the patient had clinical signs compatible with HAC; however, the low-dose dexamethasone suppression test was borderline and further examination could not be afforded. The diagnosis of thrombosis at the iliac trifurcation was obtained through ultrasonographic examination. Computed tomographic and nuclear resonance imaging could have been applied as well. The medical management of the thromboembolic disease was based on anticoagulant therapy with both heparin and clopidogrel in association with surgical thrombectomy and coronary stents placement. Despite the efforts, the patient died shortly after the surgical procedure, which was expected since high rates of mortality and morbidity is often related to the thromboembolic ischemia. The necroscopic examination of the animal found thrombi at the stents, cranial aorta, and microscopically in several tissues. The failure to directly treat the cause of the thrombus, which could not be diagnosed in time, may negatively interfered in patient survival time. The thrombectomy and coronary stents placement reestablished the femoral pulse immediately after surgery, which has been reported in other studies. The surgical resolution of aortic thrombus should be addressed in further studies.

Na Medicina Veterinária o uso de métodos alternativos tem sido explorado com intuito de substituir a utilização de animais como recurso didático. O objetivo deste estudo foi analisar a opinião dos estudantes em relação ao uso de um modelo de baixo custo para treinamento de ovariosalpingohisterectomia em pequenos animais antes da realização no animal in vivo. Foram envolvidos 21 estudantes da graduação da disciplina de Técnica Cirúrgica Veterinária, que realizaram o treinamento no modelo, antes de realizar a cirurgia no animal e depois responderam um questionário a respeito do uso do modelo, incluindo organização da equipe, segurança emocional e treinamento da técnica. A maioria dos estudantes (95,2%) consideraram que o treinamento melhorou o fluxo de tarefas, 85,7% sentiram-se mais seguros em realizar a cirurgia no animal vivo após o treinamento com o modelo e 76,2% consideraram que o treinamento acarretou melhora na habilidade cirúrgica para realização da cirurgia. Também houve redução em 23,2% (32 minutos) no tempo cirúrgico no animal vivo, comparado à turma do ano anterior sem treinamento no modelo. A utilização do modelo teve resultados positivos, pois além de ser bem aceita pelos estudantes, trouxe maior confiança e habilidade técnica durante a cirurgia, diminuindo o tempo de procedimento.

The agreement between the electrocardiographic waves measured from tracings recorded in right lateral recumbency and several other unusual body positions was assessed. Electrocardiograms were recorded in 160 healthy dogs in right lateral, left lateral, dorsal and sternal recumbencies, as well as in standing position. Considering the right lateral recordings as the gold standard, the lowest biases for the majority of ECG parameters were calculated from left lateral recordings, whereas the highest biases were documented from dorsal and standing positions. For the mean electrical axis, the dorsal recumbency produced the lowest bias, while the greatest one was identified in sternal position. An analysis of variance indicated differences when the means of P wave duration and amplitude, duration of QRS and QT, and mean electrical axis obtained in unusual positions were compared with right lateral. In conclusion, left lateral recumbency produced the most similar measurements as compared to right lateral, but the wide limits of agreement preclude the use and interpretation of these positions interchangeably.

RESUMO O stent endovascular autoexpansível pode ser utilizado como forma de tratamento para estenose uretral em cães. O stent de nitinol é composto por uma liga de níquel e titânio que permite mudanças em suas estruturas sob a influência da temperatura corporal e tem excelente biocompatibilidade na uretra canina. Este estudo relata o caso de um cão, sem raça definida, 14 anos de idade, com histórico de disúria há duas semanas, diagnosticado com grande quantidade de cálculos e microcálculos na bexiga, no colo vesical e na uretra prostática, também cistite e hiperplasia prostática. Depois de tratamento para cistite, orquiectomia e cistotomia para retirada dos cálculos, porém sem melhora clínica após 30 dias de acompanhamento, com o paciente apresentando disúria, foi realizada uretrocistografia retrógrada, que evidenciou estenose da uretra prostática. Esse paciente foi encaminhado para procedimento de implantação de um stent de nitinol na uretra prostática. Imediatamente após o procedimento e até o presente momento, o paciente apresenta micção espontânea, sem qualquer sinal de disúria, sendo este o primeiro relato no Brasil do uso dessa técnica. ABSTRACT The endovascular stent is used for treatment of urethral stricture in dogs. The nitinol stent is composed by nickel and titanium alloy that allows changes in its structures under the influence of body temperature and has excellent biocompatibility in the canine urethra. This study aims to report a case of a 14 - year - old male dog without defined breed with dysuria for two weeks. Ultrasonographic evaluation revealed microcalculi and calculi in bladder, prostatic urethral obstruction and prostatic hyperplasia. Cystotomy was performed to remove uroliths, but after 30 days of hospitalization there was no clinical improvement. A double-contrast retrograde urethrocystography was performed and showed persistence of prostatic urethral obstruction. The pacient was submitted to a new surgery to place a self-expanding nitinol stent and presented spontaneous urination after the procedure. This is the first report of this technique in Brazil.

Ventricular systolic dynamics involves the contraction of transverse and longitudinal myocardial fibers. Unfortunately, only the activity of the transverse myocardial fibers is foreseen by the standard systolic echocardiographic parameters. Although strain and strain rate have been used to assess the radial, circumferential and longitudinal planes of cardiac contraction, such analysis requires advanced equipment which is not always available in veterinary medicine. On the contrary, some unusual parameters may be recorded via standard methodology, allowing for the specific evaluation of left ventricular longitudinal contractility. In this study, the longitudinal contractile activity was evaluated using the long-axis fractional shortening and the mitral annulus motion, which were compared with several standard echocardiographic parameters in 14 beagles, including seven with asymptomatic mitral valve disease. The long-axis fractional shortening was positively correlated with both the mitral annulus motion and the end-diastolic left-ventricular diameter. Also, a significant correlation was found to exist between the mitral annulus motion and the left-ventricular end-diastolic diameter, which is likely supportive of its preload dependency. Even though no difference was documented in either mitral annulus motion or long-axis fractional shortening between healthy dogs and dogs with mitral valve disease, the latter only included animals with minimal cardiac remodeling, with no overt compromise of systolic function. Since it is possible to obtain these two parameters with any echocardiographic equipment, their inclusion in the routine exam would probably add information regarding the activity of the longitudinal myocardial fibers, whose functional deterioration supposedly occurs prior to the impairment of transverse fibers.

Spirocerca lupi is a nematode parasite that can be found in the esophagus and aorta of carnivores, including humans. Affected animals may develop mild to severe lesions, depending on the degree of infection, route of larval migration and the inflammatory response. The present work describes the occurrence of S. lupi in a 16-year old male Chow Chow dog, presenting a chronic esophagus infection, associated with a critical obstruction. After the identification of the parasite egg by faecal exam, the patient was treated with milbemycin in combination with praziquantel P.O., in days zero, seven and 28 after the diagnose. An esophagogram was also performed, confirming the secondary megaesophagus. The team of clinicians decide to perform a euthanasia due to the complication of the patient's condition, even after the anthelmintic treatment. This report is important as it describes a case after 18 years of epidemiological silence in the Metropolitan region of Curitiba, PR, Brazil. The present data aims to raise awareness about the prevalence of this zoonotic disease and the importance of a specific clinical and radiographic diagnose in dogs. It is noteworthy to report the difficulty to reduce the size of the associated esophagus mass even after a potent anthelmintic treatment.

Although only a few studies have focused on the cardiac alterations inLeishmaniaspp. infected dogs, myocardial inflammation ascribed to such parasite has been documented in some animals. In spite of the increasing popularity of cardiac biomarkers in veterinary medicine in recent years, it remains unknown how most of these substances would perform in dogs with visceral leishmaniasis. In this study, we hypothesised thatLeishmaniaspp. would damage cardiac myofibers resulting in increased circulating levels of cardiac specific markers in dogs. Therefore, biomarkers of myocyte injury and stress were investigated in 18 dogs with naturally-occurring visceral leishmaniasis presenting varying clinical signs, including completely asymptomatic animals. The median (min-max) concentrations of NT-proANP, NT-proBNP, cTnI, and CK-MB were 1138.0 (875-1175) pmol/L, 1160.0 (803-2034) fmol/L, 0.22 (0.15-0.51) ng/mL, and 116.7 (113-222) U/L, respectively. No differences were documented for the concentration of the natriuretic peptides and CK-MB in accordance with the severity of clinical signs, but for cTnI a significant difference was reported when comparing asymptomatic and symptomatic animals. Also, the compromise of renal tubular function seemed to interfere with the concentration of the natriuretic peptides and cTnI. In conclusion, all cardiac-specific biomarkers were elevated when compared to the normal range previously proposed for dogs. Measuring specific cardiac biomarkers has the potential to non-invasively document myocardial injuries attributable to visceral leishmaniasis., A pesar de que solo unos pocos estudios se han centrado en las alteraciones cardíacas en perros infectados por laLeishmaniaspp., la inflamación miocárdica atribuida a este parásito ha sido documentada en algunos animales. Los marcadores cardiacos en medicina veterinaria han experimentado una creciente popularidad en los últimos años, sin embargo aún no se sabe cómo la mayoría de estas substancias se comporta en perros con leishmaniasis visceral. En este estudio, se presume queLeishmaniaspp. dañaría fibras cardiacas causando un aumento de los niveles circulantes de marcadores cardiacos en perros. Biomarcadores de lesión y de estrés de los miocitos fueron investigados en 18 perros con infección natural porLeishmaniaspp. y que presentaban diversos signos clínicos, incluyendo los animales totalmente asintomáticos. La mediana (mín-máx) de las concentraciones de NT-proANP, NT-proBNP, cTnI, CK-MB fueron 1138,0 (875-1175) pmol/L, 1160,0 (803-2034) fmol/L, 0,22 (0,15 -0,51) ng/mL y 116,7 (113-222) U/L, respectivamente. No se registraron diferencias para la concentración de los péptidos natriuréticos y CK-MB de conformidad con la gravedad de los síntomas clínicos, pero para la cTnI se observó diferencia significativa al comparar los animales sintomáticos y asintomáticos. Además, el compromiso de función tubular renal parece interferir con la concentración de los péptidos natriuréticos y la cTnI. En conclusión, todos los cardiobiomarcadores específicos estaban elevados en comparación con el rango normal anteriormente propuesto para perros. La cuantificación de determinados biomarcadores cardíacos tiene el potencial de identificar, de forma no invasiva, lesiones miocárdicas atribuidas a la leishmaniasis visceral.

The Tei index of myocardial performance is a noninvasive echocardiographic parameter that combines systolic and diastolic time intervals to assess global cardiac performance. It was demonstrated to be a reliable indicator of myocardial dysfunction in dogs with varying clinical conditions. Because only a few studies focused on the measurement of the index in healthy dogs, this cross-sectional study was conceived to investigate how it performs in a large population of clinically healthy Beagle dogs. Our results showed no correlation between the index and body weight, heart rate, and several standard echocardiographic measures which are estimates of preload and afterload. There was no difference between de index calculated for males or females. Also, results indicated strong intra-observer and inter-observer correlations. In conclusion, the Tei index was shown to perform independently of loading conditions, besides being a straightforward and easily reproducible parameter. &nbsp, El índice de rendimiento miocárdico es un parámetro ecocardiográfico no invasivo que combina intérvalos de tiempo sistólico y diastólico para evaluar el rendimiento cardiaco total. Se ha demostrado que es un indicador fiable de disfunción miocárdica en perros con diferentes condiciones clínicas. Debido a que pocos estudios se centraron en la medición de este índice en perros sanos, este estudio transversal fue concebido para investigar este rendimiento en una gran población de perros Beagle clínicamente sanos. Nuestros resultados no muestran correlación entre el índice y el peso corporal, la frecuencia cardiaca, y varias medidas ecocardiográficas que son estimaciones estándar de precarga y poscarga. No hubo diferencia entre machos y hembras para el índice calculado. Además, los resultados indicaron notorias correlaciones intraobservador e interobservador. En conclusión, el índice de Tei se mostró como un parámetro independiente de las condiciones de la carga, que además de ser fácil de calcular también es un parámetro de fácil reproducción. &nbsp

Measurement of body temperature is a routine part of the clinical assessment of a patient. However, this procedure may be time-consuming and stressful to most animals because the standard site of temperature acquisition remains the rectal mucosa. Although an increasing number of clinicians have been using auricular temperature to estimate core body temperature, evidence is still lacking regarding agreement between these two methods in cats. In this investigation, we evaluated the agreement between temperatures measured in the rectum and ear in 29 healthy cats over a 2-week period. Temperatures were measured in the rectum (using digital and mercury-in-glass thermometers) and ear once a day for 14 consecutive days, producing 406 temperature readings for each thermometer. Mean temperature and confidence intervals were similar between methods, and Bland–Altman plots showed small biases and narrow limits of agreement acceptable for clinical purposes. The interobserver variability was also checked, which indicated a strong correlation between two near-simultaneous temperature readings. Results are consistent with auricular thermometry being a reliable alternative to rectal thermometry for assessing core body temperature in healthy cats.

It was studied fortuitous cardiorespiratory and bispectral index changes in dogs anesthetized with isoflurane associated or not to tramadol. Sixteen dogswere distributed in two groups named CG (control group) and TG (tramadol group). General anesthesia was induced in all animals with isoflurane via mask. After 10 minutes, the animals of CG received 0.05ml/kg of saline solution at 0.9%, and TG received 2mg/kg of tramadol, both via intramuscular. It was evaluated heart rate, systolic, diastolic and mean arterial pressures; electrocardiography; respiratory rate; oxihemoglobin saturation; end tidal carbon dioxide; bispectral index and recovery of anesthesia. The administration of tramadol in dogs anesthetized with isoflurane did not produce changes in cardiorespiratory variables, bispectral index and anesthetic recovery time. In addition, this association promoted good quality of anesthetic recovery. Foram avaliadas possíveis alterações cardiorrespiratórias e no índice biespectral em cães anestesiados pelo isofluorano, associado ou não ao tramadol. Utilizaram-se 16 animais, distribuídos em dois grupos denominados GC (grupo-controle) e GT (grupo tramadol). Todos os cães foram induzidos e mantidos sob anestesia com isofluorano. Os animais do GC receberam 0,05ml/kg de solução salina a 0,9% e os do GT 2mg/kg de tramadol, ambos por via intramuscular. Foram avaliados: freqüência cardíaca, pressão arterial sistólica, diastólica e média, eletrocardiografia, freqüência respiratória, saturação de oxiemoglobina, concentração de dióxido de carbono ao final da expiração, índice biespectral e recuperação da anestesia. Concluiu-se que a administração de tramadol em cães anestesiados pelo isofluorano não produz alterações nas variáveis cardiorrespiratórias, no índice biespectral e no tempo de recuperação da anestesia, porém proporciona boa qualidade de recuperação anestésica.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:55:47Z No. of bitstreams: 1 S0102-09352006000600012.pdf: 280157 bytes, checksum: 690eca2ab59c40b750f3404f59600f2f (MD5) Made available in DSpace on 2013-08-22T18:55:47Z (GMT). No. of bitstreams: 1 S0102-09352006000600012.pdf: 280157 bytes, checksum: 690eca2ab59c40b750f3404f59600f2f (MD5) Previous issue date: 2006-12-01 Made available in DSpace on 2013-09-30T19:49:03Z (GMT). No. of bitstreams: 2 S0102-09352006000600012.pdf: 280157 bytes, checksum: 690eca2ab59c40b750f3404f59600f2f (MD5) S0102-09352006000600012.pdf.txt: 37490 bytes, checksum: 319f8b66202e252a5f92102a15e5fd73 (MD5) Previous issue date: 2006-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:12:59Z No. of bitstreams: 2 S0102-09352006000600012.pdf: 280157 bytes, checksum: 690eca2ab59c40b750f3404f59600f2f (MD5) S0102-09352006000600012.pdf.txt: 37490 bytes, checksum: 319f8b66202e252a5f92102a15e5fd73 (MD5) Made available in DSpace on 2014-05-20T15:12:59Z (GMT). No. of bitstreams: 2 S0102-09352006000600012.pdf: 280157 bytes, checksum: 690eca2ab59c40b750f3404f59600f2f (MD5) S0102-09352006000600012.pdf.txt: 37490 bytes, checksum: 319f8b66202e252a5f92102a15e5fd73 (MD5) Previous issue date: 2006-12-01 Estudaram-se possíveis alterações hemodinâmicas e intracranianas em cães submetidos à hemorragia aguda e anestesiados pelo isofluorano. Verificou-se também a influência do anestésico no mecanismo de auto-regulação cerebral. Utilizaram-se 20 cães adultos que foram induzidos à anestesia geral com isofluorano por máscara naso-oral a 3,5V% (volume %). Após a intubação orotraqueal, reajustou-se o vaporizador para 2,1V%. Induziu-se a hipovolemia retirando-se volume total de 35ml/kg de sangue. Avaliaram-se pressão intracraniana (PIC), temperaturas intracraniana (TIC) e corpórea (T), pressão de perfusão cerebral (PPC), pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM), freqüências cardíaca (FC) e respiratória (FR), índices cardíaco (IC) e sistólico (IS), pressão venosa central (PVC), pressão da artéria pulmonar (PAP), concentração de dióxido de carbono ao final da expiração (ETCO2) e saturação de oxihemoglobina (SpO2). Imediatamente após a hipovolemia, houve redução significativa da PIC, PPC, PAS, PAD, PAM, IC, IS e PAP. Após 10 minutos, houve aumento gradativo das médias, permanecendo neste patamar até o final do período experimental. Concluiu-se que a hemorragia aguda promoveu redução das variáveis hemodinâmicas, sendo possível verificar a ativação de mecanismos compensatórios. Além disso, houve redução da perfusão sangüínea e ativação do mecanismo de auto-regulação cerebral, conseqüentes à hipovolemia associada à anestesia com isofluorano. Intracranial and hemodynamic alterations in 20 adult dogs anesthetized with isoflurane and submitted to acute hemorrhage were studied. Anesthetic influence on cerebral auto-regulation mechanism was also observed. General anesthesia was induced with at 3.5V% (volume %) isoflurane. Thereafter, orotracheal intubation was performed and vaporizer was calibrated to 2.1V%. To induce hypovolemia, a total amount of 35 ml/kg-1 of blood was taken from each dog. Intracranial pressure (ICP); intracranial (ICT) and body temperatures (BT); cerebral perfusion pressure (CPP); systolic (SAP), diastolic (DAP) and mean arterial pressures (MAP); heart (HR) and respiratory rates (RR); cardiac (CI) and stroke indexes (SI); central venous pressure (CVP); pulmonary arterial pressure (PAP); end tidal dioxide carbon (ETCO2); and oxyhemoglobin saturation (SpO2) were evaluated. Immediately after hypovolemia, there was significative reduction of ICP, CPP, SAP, DAP, MAP, CI, SI, and PAP. Ten minutes after, the values increased gradually until the end of the experimental period. Indeed, acute hemorrhage caused reduction of hemodynamic variables and activation of the compensatory mechanisms. Cerebral blood perfusion was reduced and cerebral auto-regulation mechanism was activated due to hypovolemia associated to isoflurane anesthesia. UNESP Faculdade de Ciências Agrárias e Veterinárias UNESP Faculdade de Ciências Agrárias e Veterinárias

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:41Z No. of bitstreams: 1 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) Made available in DSpace on 2013-08-22T18:59:41Z (GMT). No. of bitstreams: 1 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) Previous issue date: 2005-12-01 Made available in DSpace on 2013-09-30T19:56:48Z (GMT). No. of bitstreams: 2 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) S0103-84782005000600019.pdf.txt: 28008 bytes, checksum: f498f80b5c201817f8a5a7e821df584f (MD5) Previous issue date: 2005-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:46Z No. of bitstreams: 2 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) S0103-84782005000600019.pdf.txt: 28008 bytes, checksum: f498f80b5c201817f8a5a7e821df584f (MD5) Made available in DSpace on 2014-05-20T15:14:46Z (GMT). No. of bitstreams: 2 S0103-84782005000600019.pdf: 53049 bytes, checksum: cace24a9ef47e7a0f17356ce18660ef2 (MD5) S0103-84782005000600019.pdf.txt: 28008 bytes, checksum: f498f80b5c201817f8a5a7e821df584f (MD5) Previous issue date: 2005-12-01 Avaliaram-se os efeitos da hipovolemia aguda em cães anestesiados pelo isofluorano sobre a eletrocardiografia com a duração e amplitude da onda P (Pms e PmV, respectivamente); intervalo entre as ondas P e R (P-R); duração do complexo QRS (QRS); amplitude da onda R (RmV); intervalo entre as ondas Q e T (Q-T) e intervalo entre as duas ondas (R-R), freqüência cardíaca (FC), índice cardíaco (IC), índice sistólico (IS) e pressões arteriais sistólica (PAS), diastólica (PAD) e média (PAM). Verificou-se também a possível influência do anestésico sobre a resposta compensatória à hipovolemia aguda. Para tal, foram utilizados 20 cães hígidos, sem raça definida, adultos, machos e fêmeas. Induziu-se a anestesia geral com isofluorano por meio de máscara naso-oral a 2,5 CAM e, após a intubação orotraqueal, o vaporizador foi ajustado em 1,5 CAM. Induziu-se a hipovolemia nos animais retirando-se volume total de 35 mlkg-1 de sangue. As mensurações foram realizadas antes da hipovolemia (M0), imediatamente após a retirada do volume total de sangue calculado (M1), e aos dez (M2), trinta (M3) e sessenta (M4) minutos. A avaliação estatística das variáveis foi efetuada por meio de Análise de Variância (ANOVA), seguida pelo teste de Tukey, considerando nível de significância de 5% (P

Bei funf unsedierten gesunden Hunden wurden die Auswirkungen einer Dobutamin Stressuntersuchung (10 bis 40 mg/kg/Min) auf das EKG studiert. Untersucht wurden Veranderungen der Dauer/Amplitude der P-Welle, des PR-Intervalls, des QRS-Komplexes, der R-Zacke, des QT-Intervalls sowie der Herzfrequenz. Zusatzlich wurde auf das Auftreten von Arrhythmien und ST-Segment Veranderungen geachtet. Es wurde festgestellt, das Dobutamin bei hoheren Infusionsraten die Uberleitung im AV-Knoten und die Dauer der totalen elektrischen Systole signifikant beeinflusst. Bei einem Hund wurde eine Episode einer anhaltenden ventrikularen Tachykardie beobachtet, welche sofort zu einem Sinusrhythmus konvertierte, nachdem die Dobutamin Infusion gestoppt worden war. Veranderungen am ST-Segment wurden keine festgestellt. Aus diesen Beobachtungen wird geschlossen, dass wahrend einem Dobutamin Stress-Test bei hoheren Dosierungen EKG-Veranderungen auftreten.

The development of a dose-dependent cardiomyopathy is the main limitation for the use of doxorubicin in chemotherapy protocols in both humans and animals. In this setting, the global myocardial function may be compromised resulting in signs of congestive heart failure. In this study, we investigated the ability of the Tei index of myocardial performance to identify myocardial dysfunction in healthy dogs receiving doxorubicin to a cumulative dose of 210 mg/m2over 147 days, comparing it with other standard echocardiographic indicators of systolic and diastolic function. Our results indicated that the Tei index, the isovolumic relaxation time, pre-ejection period and the pre-ejection period-to-left ventricular ejection time ratio were able to identify the cardiotoxic effects of doxorubicin on cardiac function when only 60 mg/m2had been administered, while the standard systolic and diastolic parameters, including left ventricular diameter at systole, ejection fraction, and fractional shortening needed at least 120 mg/mg2to deteriorate. We concluded that prolonged anthracycline therapy compromises both systolic and diastolic functions, which may be documented earlier by including the Tei index evaluation to the standard echocardiographic assessment of animals receiving doxorubicin. &nbsp, El desarrollo de una cardiomiopatía dosis dependiente es la principal limitación para el uso de doxorrubicina en protocolos de quimioterapia tanto en seres humanos como en animales. En estos casos, la función global del miocardio puede ser cedida, teniendo como resultado signos atribuibles a la insuficiencia cardíaca congestiva. En este estudio, nosotros investigamos la capacidad del índice de desempeño miocárdico de Tei para identificar disfunción de miocardio en perros sanos tratados con doxorrubicina a una dosis cumulativa de 210 mg/m2en un periodo de 147 días, comparándolo con otros indicadores ecográficos estándar de función sistólica y diastólica. Nuestros resultados indicaron que el índice de Tei, el tiempo de relajación isovolumétrica, el período de pre-eyección, y la relación período de pre-eyección/tiempo de eyección ventricular izquierda pudieron identificar los efectos cardiotóxicos de doxorrubicina en la función cardíaca cuando sólo 60 mg/m2habían sido administrados, mientras los parámetros estándar sistólicos y diastólicos, incluso el diámetro sistólico del ventrículo izquierdo, la fracción de eyección y la fracción de acortamiento, necesitaron por lo menos 120 mg/mg2para empeorar. Se concluye que la terapia prolongada con antraciclinas perjudica las funciones sistólica y diastólica, que pueden ser documentadas antes adicionándose el índice de Tei a la evaluación ecográfica estándar en animales que reciben doxorrubicina. &nbsp

As myocarditis and arrhythmias have been shown to occur in both human beings and dogs with leishmaniasis, electrocardiograms of 105 dogs serologically positive for this disease were assessed for rhythm disturbances and changes in ECG waves. A few expressive alterations were seen, including sinus arrest, right bundle branch block, and atrial premature beats in 14.3%, 4.8%, and 4.8% of the studied subjects, respectively. Also, the analysis of ECG waves showed changes suggestive of left atrium and ventricle enlargements, and myocardial hypoxia in some animals. Although cardiac compromise has been previously reported in dogs with leishmaniasis, only a small subset of dogs showed any alteration in the electrocardiogram, which cannot support the occurrence of myocarditis in this investigation.

This study assessed the effects of a single intracoronary injection of autologous stem cells on the cardiac function of dogs with Chagas cardiomyopathy. Bone-marrow-derived stem cells were delivered into the right and left coronary arteries of 5 mature dogs with mildly compromised cardiac function due to chronic Chagas cardiomyopathy. Blood pressure and electrocardiographic and echocardiographic parameters were recorded at monthly intervals for 6 mo in the 3 dogs that survived. Although no changes were observed in the electrocardiogram and blood pressure, there was a significant increase in peak velocity of aortic flow 3 mo after stem cell transplantation. Pre-ejection period, isovolumic relaxation time, and the Tei index of myocardial performance were reduced significantly 4 mo after the procedure. All significant changes persisted to the end of the study. The results suggest that the transplantation of autologous bone-marrow-derived stem cells into the coronary arteries of dogs with Chagas cardiomyopathy may have a beneficial effect but the small number of dogs studied was a limitation.

Objective To evaluate the influence of different inspired oxygen fractions (FiO 2 ) on pulmonary oxygen exchange and Tei‐index of myocardial performance in propofol‐anesthetized dogs. Study design Prospective crossover, randomized, experimental trial. Animals Eight adult dogs weighing 8.6 ± 1.8 kg. Methods The animals were anesthetized on five occasions, receiving either an FiO 2 = 1.0 (F100), 0.8 (F80), 0.6 (F60), 0.4 (F40) or 0.21 (F21). Propofol was used for induction (6.45 ± 0.69 mgkg −1 IV) followed by a continuous rate infusion (CRI, 0.7 mgkg −1 minute −1 ). The dogs breathed spontaneously. The initial measurements of arterial partial pressures of oxygen (PaO 2 ) and carbon dioxide (PaCO 2 ), arterial hemoglobin saturation (SaO 2 ), heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), stroke index (SI), pre‐ejection period (PEP) and left ventricular ejection time (LVET) were performed 30 minutes after beginning the CRI (T0) and then, at 15‐minute intervals (T15–T60). From these measurements the following were calculated; alveolar oxygen partial pressure (PAO 2 ), alveolar‐arterial oxygen gradient (AaDO 2 ), arterial oxygen partial pressure/inspired oxygen fraction ratio (PaO 2 /FiO 2 ), arterial‐to‐alveolar oxygen tension ratio (PaO 2 /PAO 2 ), respiratory index (RI), oxygen delivery ( D ˙ O 2 ), PEP/LVET ratio, isovolumic relaxation time (IVRT) and Tei‐index. Results At T30, PaCO 2 in F100 was higher than in F21. The AaDO 2 mean in F100 was greater than in other treatments. PaO 2 /FiO 2 in F21 was lower than F100 and F80 at T0 and than in F80 and F60 at T15. At T15, PaO 2 /PAO 2 and RI in F100 were higher than in F80, F60 and F21. At T30, PaO 2 /PAO 2 in F21 was lower than in F100 and F60. At T30, PEP/LVET in F100 was higher than F80, F40 and F21, which was lower than F80 and F40. Conclusion The Tei‐index and cardiovascular parameters are not affected by different FiO 2 . Clinical Relevance An FiO 2 of 1.0 and 0.21 impaired respiratory efficiency.

The present study aimed to obtain information about the uterine inflammatory response (number of polymorphonuclear neutrophilic granulocytes - PMNs) in bitches after artificial insemination (AI) and identify the uterine microflora present after the following treatments: insemination using semen with extender (n=6), insemination with fresh semen (n=6) and no inseminated (n=6). The percentage of PMNs on the endometrial surface and within histological sections was evaluated together with the presence of aerobic bacteria in the uterine lumen. For endometrial cytology, there was no significative difference on the number of inflammatory cells between bitches not inseminated (3.05 ± 1.74 PMNs) and those inseminated with fresh semen (3.55 ± 1.51 PMNs); There was a significative difference in both groups compared to the inseminated with semen plus extender (7.80 ± 1.67 PMNs) (p

Objective To compare cardiac output (CO) measured by Doppler echocardiography and thermodilution techniques in spontaneously breathing dogs during continuous infusion of propofol. To do so, CO was obtained using the thermodilution method (CO TD ) and Doppler evaluation of pulmonary flow (CO DP ) and aortic flow (CO DA ). Study design Prospective cohort study. Animals Eight adult dogs weighing 8.3 ± 2.0 kg. Methods Propofol was used for induction (7.5 ± 1.9 mg kg −1 IV) followed by a continuous rate infusion at 0.7 mg kg −1 minute −1 . The animals were positioned in left lateral recumbency on an echocardiography table that allowed for positioning of the transducer at the 3rd and 5th intercostal spaces of the left hemithorax for Doppler evaluation of pulmonary and aortic valves, respectively. CO DP and CO DA were calculated from pulmonary and aortic velocity spectra, respectively. A pulmonary artery catheter was inserted via the jugular vein and positioned inside the lumen of the pulmonary artery in order to evaluate CO TD . The first measurement of CO TD , CO DP and CO DA was performed 30 minutes after beginning continuous infusion (T0) and then at 15‐minute intervals (T15, T30, T45 and T60). Numeric data were submitted to two‐way anova for repeated measurements, Pearson’s correlation coefficient and Bland & Altman analysis. Data are presented as mean ± SD. Results At T0, CO TD was lower than CO DA . CO DA was higher than CO TD and CO DP at T30, T45 and T60. The difference between the CO TD and CO DP , when all data were included, was −0.04 ± 0.22 L minute −1 and Pearson’s correlation coefficient ( r ) was 0.86. The difference between the CO TD and CO DA was −0.87 ± 0.54 L minute −1 and r = 0.69. For CO TD and CO DP , the difference was −0.82 ± 0.59 L minute −1 and r = 0.61. Conclusion Doppler evaluation of pulmonary flow was a clinically acceptable method for assessing the CO in propofol‐anesthetized dogs.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:22Z No. of bitstreams: 1 S0102-09352010000200009.pdf: 177511 bytes, checksum: bf1b376a69785f9d34747cabe35f19e3 (MD5) Made available in DSpace on 2013-08-22T18:56:22Z (GMT). No. of bitstreams: 1 S0102-09352010000200009.pdf: 177511 bytes, checksum: bf1b376a69785f9d34747cabe35f19e3 (MD5) Previous issue date: 2010-04-01 Made available in DSpace on 2013-09-30T19:50:12Z (GMT). No. of bitstreams: 2 S0102-09352010000200009.pdf: 177511 bytes, checksum: bf1b376a69785f9d34747cabe35f19e3 (MD5) S0102-09352010000200009.pdf.txt: 29096 bytes, checksum: d21b7f0b17afa0f99cdb338e4aa4bf61 (MD5) Previous issue date: 2010-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:13:08Z No. of bitstreams: 2 S0102-09352010000200009.pdf: 177511 bytes, checksum: bf1b376a69785f9d34747cabe35f19e3 (MD5) S0102-09352010000200009.pdf.txt: 29096 bytes, checksum: d21b7f0b17afa0f99cdb338e4aa4bf61 (MD5) Made available in DSpace on 2014-05-20T15:13:08Z (GMT). No. of bitstreams: 2 S0102-09352010000200009.pdf: 177511 bytes, checksum: bf1b376a69785f9d34747cabe35f19e3 (MD5) S0102-09352010000200009.pdf.txt: 29096 bytes, checksum: d21b7f0b17afa0f99cdb338e4aa4bf61 (MD5) Previous issue date: 2010-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Avaliaram-se os efeitos da infusão contínua de propofol ou de etomidato sobre as variáveis intracranianas em cães nomocapneicos. Foram utilizados 20 cães adultos distribuídos aleatoriamente em dois grupos: grupo propofol (GP) e grupo etomidato (GE). Para o GP, os animais foram induzidos à anestesia com propofol (10mg/kg) e, ato contínuo, iniciaram-se a infusão do fármaco (0,6mg/kg/min) e a ventilação controlada. No GE, o etomidato foi usado para indução (5mg/kg) e manutenção empregando-se a dose de 0,5mg/kg/min nos 10 minutos iniciais e, em seguida, de 0,2mg/kg/min. Após 30 minutos da implantação do cateter de fibra óptica do monitor de pressão intracraniana (PIC) na superfície do córtex cerebral direito, realizaram-se as primeiras mensurações (M1) da PIC, da pressão de perfusão cerebral (PPC), da temperatura intracraniana (TIC), de temperatura corpórea (TC), da pressão arterial média (PAM) e da frequência cardíaca (FC). As demais mensurações ocorreram em intervalos de 20 minutos (M2, M3 e M4). O propofol e o etomidato não ocasionaram alterações significativas nas variáveis estudadas com exceção da TC e TIC. Concluiu-se que a infusão contínua desses fármacos em cães mantém a perfusão cerebral e a autorregulação cerebral. Cães anestesiados com etomidato apresentam efeitos adversos intensos e redução gradativa da temperatura corpórea e intracraniana. The effects of total intravenous infusion of propofol or etomidate on intracranial variables in normocapneic dogs were evaluated. Twenty adult mongrel dogs were randomly allotted to: propofol group (GP) or etomidate group (GE). In GP animals, the propofol was used for induction (10mg/kg), followed by immediate continuous infusion of the drug (0.6mg/kg/min) and controlled ventilation. In GE dogs, the etomidate was used for induction (5mg/kg), followed by a continuous rate infusion (CRI) at 0.5mg/kg/min during the first ten minutes and, right after, it was changed to 0.2mg/kg/min. The initial measurement (M1) was recorded 30 minutes after the implant of the fiber optic catheter and, after that, every 20 minutes (M2, M3, and M4). The studied parameters were intracranial pressure (ICP), cerebral perfusion pressure (CPP), intracranial temperature (ICT), body temperature (BT), mean arterial pressure (MAP), and heart rate (HR). The propofol and etomidate did not change the studied variables, except the ICT and BT. It was concluded that the continuous infusion of these drugs maintains the cerebral perfusion and autoregulation. Dogs anesthetized with etomidate have adverse effects and body and intracranial temperature decrease. UNESP Faculdade de Ciências Agrárias e Veterinárias Universidade de Franc UFTO Escola de Medicina Veterinária e Zootecnia UNESP FMVA UNESP Faculdade de Ciências Agrárias e Veterinárias UNESP FMVA

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:13Z No. of bitstreams: 1 S0102-09352009000200010.pdf: 188938 bytes, checksum: 7dbe9e7b960fa46a028d2cc8929f4828 (MD5) Made available in DSpace on 2013-08-22T18:56:13Z (GMT). No. of bitstreams: 1 S0102-09352009000200010.pdf: 188938 bytes, checksum: 7dbe9e7b960fa46a028d2cc8929f4828 (MD5) Previous issue date: 2009-04-01 Made available in DSpace on 2013-09-30T19:49:55Z (GMT). No. of bitstreams: 2 S0102-09352009000200010.pdf: 188938 bytes, checksum: 7dbe9e7b960fa46a028d2cc8929f4828 (MD5) S0102-09352009000200010.pdf.txt: 33549 bytes, checksum: 90fff0421ced58d3156c425b7a478779 (MD5) Previous issue date: 2009-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:00Z No. of bitstreams: 2 S0102-09352009000200010.pdf: 188938 bytes, checksum: 7dbe9e7b960fa46a028d2cc8929f4828 (MD5) S0102-09352009000200010.pdf.txt: 33549 bytes, checksum: 90fff0421ced58d3156c425b7a478779 (MD5) Made available in DSpace on 2014-05-20T13:14:00Z (GMT). No. of bitstreams: 2 S0102-09352009000200010.pdf: 188938 bytes, checksum: 7dbe9e7b960fa46a028d2cc8929f4828 (MD5) S0102-09352009000200010.pdf.txt: 33549 bytes, checksum: 90fff0421ced58d3156c425b7a478779 (MD5) Previous issue date: 2009-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Avaliaram-se os efeitos do fornecimento de diferentes frações inspiradas de oxigênio (FiO2) em cães anestesiados com infusão contínua de propofol e mantidos em ventilação espontânea sobre os parâmetros ecocardiográficos, obtidos em modo M. Oito cães adultos foram submetidos a cinco protocolos anestésicos diferenciando um do outro pela FiO2 fornecida ao paciente. Formaram-se cinco grupos denominados G100 (FiO2=1), G80 (FiO2=0,8), G60 (FiO2=0,6), G40 (FiO2=0,4) e G20 (FiO2=0,21). Os animais foram induzidos à anestesia com propofol na dose necessária para intubação e, ato contínuo, iniciou-se a infusão do fármaco. Os cães receberam oxigênio conforme a FiO2 determinada para cada grupo. As primeiras mensurações foram efetuadas antes da administração do fármaco (M0), aos 30 minutos (M30) após o início da infusão do anestésico e a cada 15 minutos (M45, M60, M75 e M90) durante 60 minutos. Para espessura do septo interventricular ao final da sístole (ESIVs) registrada em M60, a média de G100 foi maior do que as obtidas de G60 e G20. em M30, o espessamento fracional da parede livre do ventrículo esquerdo (ELPVE) de G100 foi menor que de G80, e, em M75, G80 foi maior que G40. em relação ao índice de volume ventricular esquerdo ao final da sístole (IVVEFs), em M45, G40 foi maior que G80. Conclui-se que as variáveis ecocardiográficas estudadas não são afetadas pelo emprego de diferentes FiO2. The effects of several inspired oxygen fractions (FiO2) on the echocardiographic parameters by M-mode were evaluated in eight adult spontaneously breathing mongrel dogs anesthetized with continuous infusion of propofol. Each animal underwent five anesthesia procedures. In each procedure, the patient was allowed to breath a different FiO2, thereby resulting in five groups, namely: G100 (FiO2 = 1), G80 (FiO2 = 0.8), G60 (FiO2 =0.6), G40 (FiO2 = 0.4), and G20 (FiO2 = 0.21). To induce anesthesia, propofol was given until the animals allowed orotracheal intubation, followed by immediate continuous infusion of propofol. The initial measurement (M0) was performed before any drug administration, the second was recorded 30 minutes after the infusion of propofol (M30), and additional recordings were performed at 15-minute intervals (M45, M60, M75, and M90), during 60 minutes. At M60, for the end-systolic interventricular septum thickness (IVSs), the mean of G100 was greater than G60 and G20. Regarding left ventricular wall fractional thickness (LVWF) at M30, G100 was lower than G80; and at M75, G80 was greater than G40. In relation to left ventricular end-systolic volume index (ESVI), at M45, G40 was greater than G80. In conclusion, different FiO2 does not impair echocardiographic parameters. UNESP FCAV UNESP Faculdade de Ciências Agrárias e Veterinárias UFTO Escola de Medicina Veterinária e Zootecnia UNIFRAN Curso Mestrado em Cirurgia e Anestesiologia Veterinária UNESP FO Curso de Medicina Veterinária UNESP FCAV UNESP Faculdade de Ciências Agrárias e Veterinárias UNESP FO Curso de Medicina Veterinária

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:55Z No. of bitstreams: 1 S0103-84782008000300021.pdf: 60047 bytes, checksum: a84e7d4497ffb5302a4d43f8828fc742 (MD5) Made available in DSpace on 2013-08-22T18:59:55Z (GMT). No. of bitstreams: 1 S0103-84782008000300021.pdf: 60047 bytes, checksum: a84e7d4497ffb5302a4d43f8828fc742 (MD5) Previous issue date: 2008-06-01 Made available in DSpace on 2013-09-30T19:57:29Z (GMT). No. of bitstreams: 2 S0103-84782008000300021.pdf: 60047 bytes, checksum: a84e7d4497ffb5302a4d43f8828fc742 (MD5) S0103-84782008000300021.pdf.txt: 32228 bytes, checksum: 2d5e10659adb25575949e02c16b6535d (MD5) Previous issue date: 2008-06-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:14:05Z No. of bitstreams: 2 S0103-84782008000300021.pdf: 60047 bytes, checksum: a84e7d4497ffb5302a4d43f8828fc742 (MD5) S0103-84782008000300021.pdf.txt: 32228 bytes, checksum: 2d5e10659adb25575949e02c16b6535d (MD5) Made available in DSpace on 2014-05-20T13:14:05Z (GMT). No. of bitstreams: 2 S0103-84782008000300021.pdf: 60047 bytes, checksum: a84e7d4497ffb5302a4d43f8828fc742 (MD5) S0103-84782008000300021.pdf.txt: 32228 bytes, checksum: 2d5e10659adb25575949e02c16b6535d (MD5) Previous issue date: 2008-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Avaliaram-se os efeitos do fornecimento de diferentes frações inspiradas de oxigênio (FiO2) sobre os parâmetros hemodinâmicos em cães submetidos à infusão contínua de propofol e mantidos em ventilação espontânea. Foram utilizados oito cães, os quais foram empregados em cinco grupos com diferentes FiO2, G100 (FiO2 = 1), G80 (FiO2 = 0,8), G60 (FiO2 = 0,6), G40 (FiO2 = 0,4) e G20 (FiO2 = 0,21), respeitando-se um intervalo de dez dias entre cada procedimento anestésico. Os animais foram induzidos e mantidos sob anestesia com propofol na dose de 0,7mg kg-1 min-1 e, após a intubação orotraqueal, iniciou-se o fornecimento de oxigênio conforme a FiO2 determinada para cada grupo. As primeiras mensurações, da freqüência cardíaca (FC), das pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM), da resistência vascular periférica e pulmonar (RPT e RPV), do débito cardíaco (DC); da pressão venosa central (PVC), da pressão média da artéria pulmonar (PMAP), da pressão média capilar pulmonar (PMCP), da pressão parcial de oxigênio (PaO2) e do dióxido de carbono (PaCO2) no sangue arterial, foram efetuadas 30 minutos após o início da infusão do anestésico (M0), seguidas de intervalos de 15 minutos (M15, M30, M45 e M60). Os dados numéricos obtidos foram submetidos à Análise de Variância, seguida pelo teste Tukey (P

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:03Z No. of bitstreams: 1 S0102-09352008000200014.pdf: 191323 bytes, checksum: 95e43b2db6f57d7e63de4371787be9eb (MD5) Made available in DSpace on 2013-08-22T18:56:04Z (GMT). No. of bitstreams: 1 S0102-09352008000200014.pdf: 191323 bytes, checksum: 95e43b2db6f57d7e63de4371787be9eb (MD5) Previous issue date: 2008-04-01 Made available in DSpace on 2013-09-30T19:49:33Z (GMT). No. of bitstreams: 2 S0102-09352008000200014.pdf: 191323 bytes, checksum: 95e43b2db6f57d7e63de4371787be9eb (MD5) S0102-09352008000200014.pdf.txt: 33462 bytes, checksum: c2f922d7137035de8c99f452355fe137 (MD5) Previous issue date: 2008-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:13:59Z No. of bitstreams: 2 S0102-09352008000200014.pdf: 191323 bytes, checksum: 95e43b2db6f57d7e63de4371787be9eb (MD5) S0102-09352008000200014.pdf.txt: 33462 bytes, checksum: c2f922d7137035de8c99f452355fe137 (MD5) Made available in DSpace on 2014-05-20T13:13:59Z (GMT). No. of bitstreams: 2 S0102-09352008000200014.pdf: 191323 bytes, checksum: 95e43b2db6f57d7e63de4371787be9eb (MD5) S0102-09352008000200014.pdf.txt: 33462 bytes, checksum: c2f922d7137035de8c99f452355fe137 (MD5) Previous issue date: 2008-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Avaliaram-se os efeitos do fornecimento de diferentes frações inspiradas de oxigênio (FiO2) sobre o índice biespectral (BIS) em cães submetidos a infusão contínua de propofol e mantidos em ventilação espontânea. Oito cães foram submetidos a cinco anestesias, diferenciando-se uma da outra pela FiO2 fornecida. Formaram-se cinco grupos denominados G100 (FiO2 = 1); G80 (FiO2 = 0,8); G60 (FiO2 = 0,6); G40 (FiO2 = 0,4) e G20 (FiO2 = 0,21). Os animais foram induzidos à anestesia com propofol na dose necessária para intubação, e, ato contínuo, iniciaram-se a infusão do fármaco e o fornecimento de oxigênio, conforme a FiO2 determinada para cada grupo. As primeiras mensurações (M0) foram efetuadas 30 minutos após o início da infusão do anestésico e, depois, em intervalos de 15 minutos (M15, M30, M45 e M60). A pressão parcial de oxigênio no sangue arterial (PaO2) variou conforme a FiO2, ou seja, quanto maior a FiO2, maior foi a PaO2. Para a pressão parcial de dióxido de carbono no sangue arterial (PaCO2), foram registradas diferenças em M30, no qual G100 foi maior que G20. Não foram observadas diferenças significativas nas variáveis estudadas do BIS. Os intervalos de médias registrados para o BIS foram, para G100, de 68 a 62; G80, de 71 a 58; G60, de 72 a 62; G40, de 76 a 68; e G20, de 77 a 68. Conclui-se que as variáveis relacionadas ao BIS não são afetadas pelo emprego de diferentes FiO2, e sugere-se que o monitoramento pelo BIS foi capaz de detectar alterações no equilíbrio do fluxo sangüíneo cerebral, oriundas das alterações ocasionadas na dinâmica respiratória pelo emprego de diferentes frações inspiradas de oxigênio. The effects of several inspired oxygen fractions (FiO2) on the bispectral index in spontaneously breathing dogs submitted to continuous infusion of propofol were evaluated. Eight adult mongrel dogs were used. Each animal was submitted to five anesthesias. In each procedure, the patient was allowed to breathe a different FiO2, thereby resulting in five groups, namely: G100 (FiO2 = 1), G80 (FiO2 = 0.8), G60 (FiO2 =0.6), G40 (FiO2 = 0.4), and G20 (FiO2 = 0.21). To induce anesthesia, propofol was given until the animals allowed orotracheal intubation, followed by immediate continuous infusion of drug. The initial measurement (M0) was recorded 30 minutes after the infusion of propofol onset. Additional recordings were performed at 15-minute intervals during 60 minutes (M15, M30, M45, and M60). No significant differences on BIS parameters were recorded. Regarding arterial partial pressure of carbon dioxide (PaCO2), the mean of G100 was greater than G20 at M30, whereas arterial partial pressure of oxygen (PaO2) varied according to the changes in oxygen. The mean intervals of BIS were: for G100, from 68 to 62; for G80, from 71 to 58; for G60, from 72 to 62; for G40 from 76 to 68; and for G20, from 77 to 68. In conclusion, different FiO2 does not impair BIS parameters. However, it is suggested that BIS was able to detect changes in the balance of cerebral blood flow, which was a result of changes in respiratory dynamic by the use of several inspired fractions. UNESP FCAV UNESP Faculdade de Ciências Agrárias e Veterinárias Faculdade de Medicina Veterinária de Araçatuba UNESP FCAV UNESP Faculdade de Ciências Agrárias e Veterinárias

Objective To study the echocardiographic effects of isoflurane at an end-tidal concentration approximating 1.0 times the minimum alveolar concentration (MAC) in healthy unpremedicated dogs. Study design Prospective experimental trial. Animals Sixteen mature mongrel dogs of either sex weighing 11.06 ± 2.72 kg. Methods After performing a baseline echocardiogram in the awake animal, anesthesia was induced with increasing inspired concentrations of isoflurane via a face mask until tracheal intubation was possible. Following intubation, the end-tidal concentration was decreased to 1.4% for the rest of the anesthetic period. Serial echocardiograms were recorded at 25, 40, and 55 minutes after the end-tidal concentration was reached. Results No changes were observed in heart rate. However, significant decreases were seen in left ventricular end-diastolic diameter (Mean maximal change: 13.8%), interventricular septal thickness during systole (15.2%), interventricular septal thickening fraction (72.2%), left ventricular free wall thickening fraction (63.5%), ejection fraction (39.9%), and fractional shortening (46.7%). In addition, peak flow velocities across mitral, pulmonic, and aortic valves were significantly lower than baseline values. Decreases were also observed in end-diastolic left ventricular volume index (approximately 32.1% from the awake value), stroke index (58.2%), and cardiac index (55.3%) when compared with awake measurements. Conclusions and clinical relevance Our results indicate that 1 × MAC isoflurane caused significant myocardial depression in healthy dogs. These changes in myocardial function need to be considered carefully when isoflurane is to be used in dogs with poor cardiovascular reserve.

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:22:44Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:46:05Z : No. of bitstreams: 1 2-s2.0-75849123353.pdf: 764274 bytes, checksum: ff1e174c2d8c56ecffc81ff8ea1181e9 (MD5) Made available in DSpace on 2014-05-27T11:22:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-12-01 The effects of several inspired oxygen fractions (FiO 2) on the respiratory dynamics in spontaneously breathing dogs submitted to continuous infusion of propofol were evaluated. Eight adult mongrel dogs were used. Each animal underwent five anesthesias, in each procedure the patient was allowed to breath a different FiO 2, thereby resulting in five groups, namely: G100 (FiO 2 = 1), G80 (FiO 2 = 0.8), G60 (FiO 2 =0.6), G40 (FiO 2 = 0.4), and G20 (FiO 2 = 0.21). To induce anesthesia, propofol was given until the animals allowed orotracheal intubation, followed by immediate continuous infusion of drug. The initial measurement (M0) was recorded thirty minutes after the infusion of propofol has begun. Additional recordings were performed at 15 minute intervals for 60 minutes (M15, M30, M45 and M60). Numeric data were submitted to Analysis of Variance followed by Tukey Test (p

Recently, the Tei-index, a noninvasive index that combines systolic and diastolic time intervals, has been proposed to assess global cardiac performance. However, the effects of isoflurane on the Tei-index have not been characterized. This study aimed at studying the effects of 1.0 minimal alveolar concentration isoflurane anesthesia on the pre-ejection period (PEP), left ventricular ejection time (LVET), PEP/LVET ratio, isovolumic relaxation time (IVRT), stroke index (SI), cardiac index (CI), heart rate (HR), and the Tei-index in healthy unpre-medicated dogs. We observed significant increases in PEP, PEP/LVET ratio, IVRT, and TEI, whose maximal increases obtained throughout the study were 47%, 48%, 78%, and 56%, respectively. The LVET and HR did not change significantly, whereas the SI and CI decreased during anesthesia (29% and 26%, respectively). In conclusion, isoflurane produced direct effects on the Tei-index. The changes in systolic and diastolic parameters were supportive of this finding and were consistent with an overall impairment of left ventricular function during anesthesia.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:55:51Z No. of bitstreams: 1 S0102-09352007000200009.pdf: 152930 bytes, checksum: 97b242b0d34451ec5594f8727fcf6999 (MD5) Made available in DSpace on 2013-08-22T18:55:51Z (GMT). No. of bitstreams: 1 S0102-09352007000200009.pdf: 152930 bytes, checksum: 97b242b0d34451ec5594f8727fcf6999 (MD5) Previous issue date: 2007-04-01 Made available in DSpace on 2013-09-30T19:49:12Z (GMT). No. of bitstreams: 2 S0102-09352007000200009.pdf: 152930 bytes, checksum: 97b242b0d34451ec5594f8727fcf6999 (MD5) S0102-09352007000200009.pdf.txt: 17067 bytes, checksum: e0707425dcb52d6f8883ddf50e5f6fd8 (MD5) Previous issue date: 2007-04-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:15:18Z No. of bitstreams: 2 S0102-09352007000200009.pdf: 152930 bytes, checksum: 97b242b0d34451ec5594f8727fcf6999 (MD5) S0102-09352007000200009.pdf.txt: 17067 bytes, checksum: e0707425dcb52d6f8883ddf50e5f6fd8 (MD5) Made available in DSpace on 2014-05-20T13:15:18Z (GMT). No. of bitstreams: 2 S0102-09352007000200009.pdf: 152930 bytes, checksum: 97b242b0d34451ec5594f8727fcf6999 (MD5) S0102-09352007000200009.pdf.txt: 17067 bytes, checksum: e0707425dcb52d6f8883ddf50e5f6fd8 (MD5) Previous issue date: 2007-04-01 Foram avaliados os efeitos do propofol associado ao sufentanil sobre o balanço das atividades simpática e parassimpática do coração, investigando-se um possível efeito dose dependente do opióide. Analisou-se a variabilidade da freqüência cardíaca (VFC) de 12 cães adultos pré-medicados com maleato de acepromazina e anestesiados com propofol e três doses diferentes de sufentanil, que variou de 0,025 a 0,1µg/kg/min. Registrou-se o eletrocardiograma 15 minutos após a medicação pré-anestésica e 15, 30, 60, 90 e 120 minutos após a indução anestésica. A VFC foi calculada no domínio da freqüência, mediante análise de 10 intervalos RR consecutivos. Houve redução acentuada da freqüência cardíaca, mas a VFC permaneceu relativamente inalterada. The effects of propofol and sufentanil on cardiac sympathetic and parasympathetic balance were studied, in order to evaluate if sufentanil plays a role in this balance. The heart rate variability of 12 adult dogs was assessed, after premedication with acepromazine and anesthetized with propofol and three different doses of sufentanil, ranging from 0.025 to 0.1µg/kg/min. Electrocardiograms were recorded 15 minutes after premedication and 15, 30, 60, 90, and 120 minutes after anesthetic induction. Heart rate variability was calculated in frequency domain through the analysis of 10 consecutive RR intervals. Results showed an absence of important changes in heart rate variability, although a significant decrease in heart rate was observed. UNESP FCAV Faculdade de Jaguariúna UNESP Curso de Medicina Veterinária UNESP FCAV UNESP Curso de Medicina Veterinária

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:59:22Z No. of bitstreams: 1 S0103-84782002000500008.pdf: 35273 bytes, checksum: ac626164745f3dbc1caaf98f397a3461 (MD5) Made available in DSpace on 2013-08-22T18:59:22Z (GMT). No. of bitstreams: 1 S0103-84782002000500008.pdf: 35273 bytes, checksum: ac626164745f3dbc1caaf98f397a3461 (MD5) Previous issue date: 2002-10-01 Made available in DSpace on 2013-09-30T19:56:09Z (GMT). No. of bitstreams: 2 S0103-84782002000500008.pdf: 35273 bytes, checksum: ac626164745f3dbc1caaf98f397a3461 (MD5) S0103-84782002000500008.pdf.txt: 23779 bytes, checksum: 81f967ea74a4f8fc91d2f4190869987e (MD5) Previous issue date: 2002-10-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:14:37Z No. of bitstreams: 2 S0103-84782002000500008.pdf: 35273 bytes, checksum: ac626164745f3dbc1caaf98f397a3461 (MD5) S0103-84782002000500008.pdf.txt: 23779 bytes, checksum: 81f967ea74a4f8fc91d2f4190869987e (MD5) Made available in DSpace on 2014-05-20T15:14:37Z (GMT). No. of bitstreams: 2 S0103-84782002000500008.pdf: 35273 bytes, checksum: ac626164745f3dbc1caaf98f397a3461 (MD5) S0103-84782002000500008.pdf.txt: 23779 bytes, checksum: 81f967ea74a4f8fc91d2f4190869987e (MD5) Previous issue date: 2002-10-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A cetamina, fármaco derivado da fenciclidina, há muito é usada na anestesia veterinária, sendo que o seu isômero (+), a cetamina S, recém-lançada no mercado, tem tido emprego principalmente na anestesia humana. em vista disso, objetivou-se, com este experimento avaliar comparativamente, as possíveis alterações eletrocardiográficas em cães anestesiados com cetamina S ou cetamina e avaliar as freqüências respiratória e cardíaca, saturação de oxihemoglobina e pressão arterial. Para tanto, foram utilizados 10 cães adultos, machos e fêmeas, sem raça definida e hígidos. Os animais foram distribuídos em dois grupos (G1 e G2) de igual número. Ao G1 administrou-se, por via intramuscular, cetamina S na dose de 20mg/kg, e ao G2, cetamina na mesma dose e via de administração empregados no G1. As observações das variáveis tiveram início imediatamente antes da aplicação dos fármacos (M1) e a cada 10 minutos (M2, M3 e M4, respectivamente). Os dados numéricos foram submetidos ao teste de Tukey, para análises repetidas no grupo, a fim de verificar significado estatístico ou não entre as médias, nos vários momentos, sendo considerado o nível de significância de 5% (p

The article has no abstract. O artigo não apresenta resumo.

Foram avaliados os prontuarios de 1.153 caes submetidos a anestesia geral inalatoria no Hospital Veterinario Governador Laudo Natel, da Universidade Estadual Paulista, Campus de Jaboticabal-SP, no periodo de Julho de 2000 a Janeiro de 2003. Objetivou-se determinar a incidencia de mortalidade e morbidade, tentando correlaciona-las com os agentes anestesicos empregados para manutencao anestesica e a classificacao do paciente de acordo com a American Society of Anesthesiologists (ASA). A taxa de morbidade e mortalidade foi de, respectivamente, 9,19% e 1,13%. A analise dos dados revelou que as complicacoes e obitos podem ocorrer em pacientes cuja previsao de risco e inicialmente pequena, ou ainda naqueles onde os agentes anestesicos considerados mais seguros e estaveis foram utilizados. Entretanto, de acordo com a analise estatistica, nao houve correlacao entre morbidade ou mortalidade e a classificacao ASA, do paciente ou o agente anestesico utilizado.

O artigo não apresenta resumo.