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Chronic wounds in diabetic patients represent an escalating health problem, leading to significant morbidity and mortality. Our group previously reported that whole body low-intensity vibration (LIV) can improve angiogenesis and wound healing in diabetic mice. The purpose of the current study was to determine whether effects of LIV on wound healing are frequency and/or amplitude dependent. Wound healing was assessed in diabetic (db/db) mice exposed to one of four LIV protocols with different combinations of two acceleration magnitudes (0.3 and 0.6 g) and two frequencies (45 and 90 Hz) or in non-vibration sham controls. The low acceleration, low frequency protocol (0.3 g and 45 Hz) was the only one that improved wound healing, increasing angiogenesis and granulation tissue formation, leading to accelerated re-epithelialization and wound closure. Other protocols had little to no impact on healing with some evidence that 0.6 g accelerations negatively affected wound closure. The 0.3 g, 45 Hz protocol also increased levels of insulin-like growth factor-1 and tended to increase levels of vascular endothelial growth factor in wounds, but had no effect on levels of basic fibroblast growth factor or platelet derived growth factor-bb, indicating that this LIV protocol induces specific growth factors during wound healing. Our findings demonstrate parameter-dependent effects of LIV for improving wound healing that can be exploited for future mechanistic and therapeutic studies.

Presentación realizada en la 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019.

The development and propagation of a gust front is shown to be an integral part of a thunderstorm's life cycle in conceptual models and schematics. This outflow boundary has the potential to initiate new storms as well as inhibit or enhance existing storms. However, not every thunderstorm produces a gust front, and the reasons are not well understood. This deficit in knowledge leads to a lack of criteria for forecasting which storms will produce gust fronts that may generate new storms. Therefore, it is important to understand why some storms produce gust fronts and others do not. This study examined two ordinary thunderstorms--one gust front (GF) storm and one non-gust front (NGF) storm--during the 2002 International H₂O Project (IHOP). The objective was to determine if GF and NGF storms exhibit differences in terms of storm characteristics and environmental conditions. The S-band Dual Polarization (S-Pol) Doppler radar provided measurements of reflectivity (Z), differential reflectivity (Zdr), and specific differential phase (Kdp) to describe each storm’s characteristics (microphysics). Standard parameters that characterized the environment were derived from soundings at different sites within S-Pol's range. Preliminary analyses indicate some similarities and differences between GF and NGF storms--more in storm characteristics (e.g., growth rate of Z, descent of 0 Zdr, strong gradients in Kdp) than in environment (e.g., nearly similar profiles). However, more storms need to be investigated to substantiate these preliminary findings, which can help improve our understanding of GF production and forecasting.

The Mycenaeans were Bronze Age Warriors who drove Chariots into battle. The above paper is a reconstruction of these chariots and a list of items which were needed in order to build them.

This is some information on the procedure of Interpreting the many finds from an Archaeological Excavation in General.