Search

Your search keyword '"Roberts, Sheridan L."' showing total 12 results
Start Over Author "Roberts, Sheridan L."
12 results on '"Roberts, Sheridan L."'

7. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve

Author

Roberts, Sheridan L., primary, Dun, Xin-peng, additional, Doddrell, Robin D. S., additional, Mindos, Thomas, additional, Drake, Louisa K., additional, Onaitis, Mark W., additional, Florio, Francesca, additional, Quattrini, Angelo, additional, Lloyd, Alison C., additional, D'Antonio, Maurizio, additional, and Parkinson, David B., additional

Published
2017
Full Text
View/download PDF

9. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity

Author

Mindos, Thomas, primary, Dun, Xin-peng, additional, North, Katherine, additional, Doddrell, Robin D.S., additional, Schulz, Alexander, additional, Edwards, Philip, additional, Russell, James, additional, Gray, Bethany, additional, Roberts, Sheridan L., additional, Shivane, Aditya, additional, Mortimer, Georgina, additional, Pirie, Melissa, additional, Zhang, Nailing, additional, Pan, Duojia, additional, Morrison, Helen, additional, and Parkinson, David B., additional

Published
2017
Full Text
View/download PDF

11. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve.

Author

Roberts, Sheridan L., Xin-peng Dun, Doddrell, Robin D. S., Mindos, Thomas, Drake, Louisa K., Onaitis, Mark W., Florio, Francesca, Quattrini, Angelo, Lloyd, Alison C., D'Antonio, Maurizio, and Parkinson, David B.

Subjects
*SCHWANN cells, *MYELINATION, *PERIPHERAL nervous system
Abstract

Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and following peripheral nerve injury and repair. The Sox2 transcription factor is well known for its roles in the development andmaintenance of progenitor and stem cell populations, but has also been proposed in vitro as a negative regulator of myelination in Schwann cells. We wished to test fully whether Sox2 regulates myelination in vivo and show here that, in mice, sustained Sox2 expression in vivo blocks myelination in the peripheral nerves and maintains Schwann cells in a proliferative non-differentiated state, which is also associated with increased inflammation within the nerve. The plasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show that re-myelination is also blocked by Sox2 expression in Schwann cells. These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results