Search

Your search keyword '"Robertson, Courtney"' showing total 255 results
Start Over Author "Robertson, Courtney"
255 results on '"Robertson, Courtney"'

1. Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.

Author

Mainali, Shraddha, Aiyagari, Venkatesh, Alexander, Sheila, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Brown, Emery, Brown, Jeremy, Claassen, Jan, Edlow, Brian, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Frontera, Jennifer, Geocadin, Romergryko, Giacino, Joseph, Gilmore, Emily, Gosseries, Olivia, Hammond, Flora, Helbok, Raimund, Claude Hemphill, J, Hirsch, Karen, Kim, Keri, Laureys, Steven, Lewis, Ariane, Ling, Geoffrey, Livesay, Sarah, McCredie, Victoria, McNett, Molly, Menon, David, Molteni, Erika, Olson, DaiWai, OPhelan, Kristine, Park, Soojin, Polizzotto, Len, Javier Provencio, Jose, Puybasset, Louis, Venkatasubba Rao, Chethan, Robertson, Courtney, Rohaut, Benjamin, Rubin, Michael, Sharshar, Tarek, Shutter, Lori, Sampaio Silva, Gisele, Smith, Wade, Stevens, Robert, Thibaut, Aurore, Vespa, Paul, Wagner, Amy, Ziai, Wendy, Zink, Elizabeth, and I Suarez, Jose

Subjects
Coma, Curing Coma Campaign, Disorders of consciousness, National Institute of Health, Proceedings, Coma, Consciousness, Consciousness Disorders, Humans, National Institutes of Health (U.S.), United States
Abstract

This proceedings article presents actionable research targets on the basis of the presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) symposium held from May 3 to May 5, 2021. Here, we summarize the background, research priorities, panel discussions, and deliverables discussed during the symposium across six major domains related to disorders of consciousness. The six domains include (1) Biology of Coma, (2) Coma Database, (3) Neuroprognostication, (4) Care of Comatose Patients, (5) Early Clinical Trials, and (6) Long-term Recovery. Following the 1st Curing Coma NIH virtual symposium held on September 9 to September 10, 2020, six workgroups, each consisting of field experts in respective domains, were formed and tasked with identifying gaps and developing key priorities and deliverables to advance the mission of the Curing Coma Campaign. The highly interactive and inspiring presentations and panel discussions during the 3-day virtual NIH symposium identified several action items for the Curing Coma Campaign mission, which we summarize in this article.

Published
2022

3. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Author

Vespa, Paul M, Shrestha, Vikesh, Abend, Nicholas, Agoston, Denes, Au, Alicia, Bell, Michael J, Bleck, Thomas P, Blanco, Manuel Buitrago, Claassen, Jan, Diaz-Arrastia, Ramon, Duncan, Dominique, Ellingson, Ben, Foreman, Brandon, Gilmore, Emily J, Hirsch, Lawrence, Hunn, Martin, Kamnaksh, Alaa, McArthur, David, Morokoff, Andrew, O'Brien, Terrence, O'Phelan, Kristine, Robertson, Courtney L, Rosenthal, Eric, Staba, Richard, Toga, Arthur, Willyerd, Frederick A, Zimmermann, Lara, Yam, Elisa, Martinez, Susana, Real, Courtney, and Engel, Jerome

Subjects
Biomedical and Clinical Sciences, Neurosciences, Precision Medicine, Clinical Research, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Neurodegenerative, Epilepsy, Traumatic Head and Spine Injury, Traumatic Brain Injury (TBI), 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Good Health and Well Being, Biomarkers, Brain, Brain Injuries, Traumatic, Computational Biology, Epilepsy, Post-Traumatic, Humans, Longitudinal Studies, Observational Studies as Topic, Prospective Studies, Clinical Sciences, Neurology & Neurosurgery, Biochemistry and cell biology
Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

Published
2019

6. Correction to: Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

Author

Mainali, Shraddha, Aiyagari, Venkatesh, Alexander, Sheila, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Brown, Emery, Brown, Jeremy, Claassen, Jan, Edlow, Brian L., Fink, Ericka L., Fins, Joseph J., Foreman, Brandon, Frontera, Jennifer, Geocadin, Romergryko G., Giacino, Joseph, Gilmore, Emily J., Gosseries, Olivia, Hammond, Flora, Helbok, Raimund, Claude Hemphill, J., Hirsch, Karen, Kim, Keri, Laureys, Steven, Lewis, Ariane, Ling, Geoffrey, Livesay, Sarah L., McCredie, Victoria, McNett, Molly, Menon, David, Molteni, Erika, Olson, DaiWai, O’Phelan, Kristine, Park, Soojin, Polizzotto, Len, Javier Provencio, Jose, Puybasset, Louis, Venkatasubba Rao, Chethan P., Robertson, Courtney, Rohaut, Benjamin, Rubin, Michael, Sharshar, Tarek, Shutter, Lori, Sampaio Silva, Gisele, Smith, Wade, Stevens, Robert D., Thibaut, Aurore, Vespa, Paul, Wagner, Amy K., Ziai, Wendy C., Zink, Elizabeth, and Suarez, Jose I.

Published
2022
Full Text
View/download PDF

8. The Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID): Development of Case Report Forms for Global Use

Author

McNett, Molly, Fink, Ericka L., Schober, Michelle, Mainali, Shraddha, Helbok, Raimund, Robertson, Courtney L., Mejia-Mantilla, Jorge, Kurtz, Pedro, Righy, Cássia, Roa, Juan D., Villamizar-Rosales, Carlos, Altamirano, Valeria, Frontera, Jennifer A., Maldonado, Nelson, Menon, David, Suarez, Jose, and Chou, Sherry H. Y.

Published
2020
Full Text
View/download PDF

11. A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City

Author

Frontera, Jennifer A., Sabadia, Sakinah, Lalchan, Rebecca, Fang, Taolin, Flusty, Brent, Millar-Vernetti, Patricio, Snyder, Thomas, Berger, Stephen, Yang, Dixon, Granger, Andre, Morgan, Nicole, Patel, Palak, Gutman, Josef, Melmed, Kara, Agarwal, Shashank, Bokhari, Matthew, Andino, Andres, Valdes, Eduard, Omari, Mirza, Kvernland, Alexandra, Lillemoe, Kaitlyn, Chou, Sherry H.-Y., McNett, Molly, Helbok, Raimund, Mainali, Shraddha, Fink, Ericka L., Robertson, Courtney, Schober, Michelle, Suarez, Jose I., Ziai, Wendy, Menon, David, Friedman, Daniel, Friedman, David, Holmes, Manisha, Huang, Joshua, Thawani, Sujata, Howard, Jonathan, Abou-Fayssal, Nada, Krieger, Penina, Lewis, Ariane, Lord, Aaron S., Zhou, Ting, Kahn, D. Ethan, Czeisler, Barry M., Torres, Jose, Yaghi, Shadi, Ishida, Koto, Scher, Erica, de Havenon, Adam, Placantonakis, Dimitris, Liu, Mengling, Wisniewski, Thomas, Troxel, Andrea B., Balcer, Laura, and Galetta, Steven

Published
2021
Full Text
View/download PDF

15. Challenges and opportunities for pediatric severe TBI—review of the evidence and exploring a way forward

Author

Bell, Michael J., Adelson, P. David, Wisniewski, Stephen R., Agrawal, Shruti, Mahoney, Sarah, Gupta, Deepak, Beca, John, Loftis, Laura, Morris, Kevin, Piper, Lauren, Slater, Anthony, Walson, Karen, Bennett, Tellen, Kilbaugh, Todd, O’Meara, A. M. Iqbal, Dean, Nathan, Chima, Ranjit S., Biagas, Katherine, Wildschut, Enno, Peters, Mark, LaRovere, Kerri, Balcells, Joan, Robertson, Courtney, Gertz, Shira, Deep, Akash, Cooper, Sian, Wainwright, Mark, Murphy, Sarah, Kuluz, John, Butt, Warwick, O’Brien, Nicole, Thomas, Neal J., Buttram, Sandra, Erickson, Simon, Samuel, J. Mahil, Agbeko, Rachel, Edwards, Richard, Ramakrishnan, Kesava Ananth, Winkler, Margaret, Borasino, Santiago, Natale, Joanne, Giza, Christopher, Hilfiker, Mary, Shellington, David, Figaji, Anthony, Newell, Elizabeth, Truemper, Edward, Clark, Robert, Newth, Kit, Shafi, Nadeem, Miles, Darryl, Schober, Michelle, Ferrazzano, Peter, Pineda, Jose, Sarnik, Ajit, and for the Investigators of the ADAPT Study,

Published
2017
Full Text
View/download PDF

25. Considerations in Implementing Intervention Assistance Teams to Support English Language Learners

Author

Ortiz, Alba A., Wilkinson, Cheryl Y., and Robertson-Courtney, Phyllis

Abstract

Intervention assistance teams (IATs) can help teachers design and implement interventions to improve the performance of English language learners (ELLs) who are experiencing academic or behavioral difficulties, providing the supports needed to resolve many such difficulties within the context of general education. If interventions are unsuccessful and ELLs are subsequently referred for special education, eligibility decisions are informed by documentation that students did not make adequate progress despite general education problem solving and that students' problems cannot be explained by such factors as limited English proficiency or cultural differences. To be successful, however, IATs must accurately interpret data about ELLs and design culturally and linguistically responsive interventions. This article presents considerations in implementing IATs for ELLs, including team membership, the knowledge base needed by team members, intervention design, and record keeping.

Published
2006
Full Text
View/download PDF

27. Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C

Author

Fink, Ericka L., primary, Robertson, Courtney L., additional, Wainwright, Mark S., additional, Roa, Juan D., additional, Lovett, Marlina E., additional, Stulce, Casey, additional, Yacoub, Mais, additional, Potera, Renee M., additional, Zivick, Elizabeth, additional, Holloway, Adrian, additional, Nagpal, Ashish, additional, Wellnitz, Kari, additional, Czech, Theresa, additional, Even, Katelyn M., additional, Brunow de Carvalho, Werther, additional, Rodriguez, Isadora Souza, additional, Schwartz, Stephanie P., additional, Walker, Tracie C., additional, Campos-Miño, Santiago, additional, Dervan, Leslie A., additional, Geneslaw, Andrew S., additional, Sewell, Taylor B., additional, Pryce, Patrice, additional, Silver, Wendy G., additional, Lin, Jieru Egeria, additional, Vargas, Wendy S., additional, Topjian, Alexis, additional, Alcamo, Alicia M., additional, McGuire, Jennifer L., additional, Domínguez Rojas, Jesus Angel, additional, Muñoz, Jaime Tasayco, additional, Hong, Sue J., additional, Muller, William J., additional, Doerfler, Matthew, additional, Williams, Cydni N., additional, Drury, Kurt, additional, Bhagat, Dhristie, additional, Nelson, Aaron, additional, Price, Dana, additional, Dapul, Heda, additional, Santos, Laura, additional, Kahoud, Robert, additional, Francoeur, Conall, additional, Appavu, Brian, additional, Guilliams, Kristin P., additional, Agner, Shannon C., additional, Walson, Karen H., additional, Rasmussen, Lindsey, additional, Janas, Anna, additional, Ferrazzano, Peter, additional, Farias-Moeller, Raquel, additional, Snooks, Kellie C., additional, Chang, Chung-Chou H., additional, Yun, James, additional, and Schober, Michelle E., additional

Published
2022
Full Text
View/download PDF

28. Marine Attack Squadron 214 Transitions to the F-35

Author

Bodner, Zachary and Robertson, Courtney

Subjects
United States. Marine Corps, Air bases, Soldiers, Jet planes, Military, Military and naval science
Abstract

MARINE CORPS AIR STATION YUMA, Ariz. -- Marine Attack Squadron (VMA) 214, Marine Aircraft Group (MAG) 13, 3rd Marine Aircraft Wing (MAW), conducted a redesignation ceremony March 25 at Marine [...]

Published
2022

30. Common Data Elements for COVID-19 Neuroimaging: A GCS-NeuroCOVID Proposal

Author

Edlow, Brian L., Boly, Melanie, Chou, Sherry H.Y., Fischer, David, Kondziella, Daniel, Li, Lucia M., Mac Donald, Christine L., McNett, Molly, Newcombe, Virginia F.J., Stevens, Robert D., Menon, David K., Chou, Sherry, Helbok, Raimund, Mainali, Shraddha, Robertson, Courtney, Schober, Michelle, Fink, Ericka L., Edlow, Brian L [0000-0001-7235-8456], Apollo - University of Cambridge Repository, and Edlow, Brian L. [0000-0001-7235-8456]

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Neurology, Common Data Elements, Coronavirus disease 2019 (COVID-19), business.industry, Extramural, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), International Cooperation, MEDLINE, Clinical Neurology, COVID-19, Neuroimaging, Critical Care and Intensive Care Medicine, Special Article, medicine, Humans, Neurology (clinical), Neurosurgery, Nervous System Diseases, business, Intensive care medicine
Abstract

Funder: National Institute of Neurological Disorders and Stroke; doi: http://dx.doi.org/10.13039/100000065, Funder: James S. McDonnell Foundation; doi: http://dx.doi.org/10.13039/100000913, Funder: National Institute of Health Research, Funder: United Kingdom Research and Innovation, Funder: Addenbrooke’s Charitable Trust

Published
2021

31. Perioperative Management of Pediatric Patients with Moyamoya Arteriopathy

Author

Gardner Yelton, Sarah E., additional, Williams, Monica A., additional, Young, Mollie, additional, Fields, Jennifer, additional, Pearl, Monica S., additional, Casella, James F., additional, Lawrence, Courtney E., additional, Felling, Ryan J., additional, Jackson, Eric M., additional, Robertson, Courtney, additional, Scafidi, Susanna, additional, Lee, Jennifer K., additional, Cohen, Alan R., additional, and Sun, Lisa R., additional

Published
2021
Full Text
View/download PDF

32. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

Author

Tubi, Meral A., Lutkenhoff, Evan, Blanco, Manuel Buitrago, McArthur, David, Villablanca, Pablo, Ellingson, Benjamin, Diaz-Arrastia, Ramon, Van Ness, Paul, Real, Courtney, Shrestha, Vikesh, Engel, Jerome, Vespa, Paul M., Agoston, Denes, Au, Alicia, Bell, Michael J., Bleck, Tom, Branch, Craig, Buitrago Blanco, Manuel, Bullock, Ross, Burrows, Brian T., Claassen, Jan, Clarke, Robert, Cloyd, James, Coles, Lisa, Crawford, Karen, Duncan, Dominique, Foreman, Brandon, Galanopoulou, Aristea, Gilmore, Emily, Olli, Grohn, Harris, Neil, Hartings, Jed, Lawrence, Hirsch, Hunn, Martin, Jette, Nathalie, Johnston, Leigh, Jones, Nigel, Kanner, Andres, Monti, Martin, Morokoff, Andrew, Moshe, Solomon, Mowrey, Wenzhu, O’Brien, Terence, O’Phelan, Kristine, Pitkanen, Asla, Raman, Rema, Robertson, Courtney, Rosenthal, Eric, Shultz, Sandy, Snutch, Terrance, Staba, Richard, Toga, Arthur, Van Horn, Jack, Vespa, Paul, Willyerd, Frederick, and Zimmermann, Lara

Subjects
0301 basic medicine, Male, Traumatic, Pediatrics, Brain atrophy, Neurodegenerative, Epileptogenesis, Severity of Illness Index, Epilepsy, 0302 clinical medicine, Brain Injuries, Traumatic, 2.1 Biological and endogenous factors, Longitudinal Studies, Prospective Studies, Post-traumatic epilepsy, Aetiology, Coma, Prospective cohort study, Status epilepticus, screening and diagnosis, Head injury, Temporal Lobe, Detection, Neurology, Neurological, Female, medicine.symptom, Adult, medicine.medical_specialty, Physical Injury - Accidents and Adverse Effects, Traumatic brain injury, Clinical Sciences, Traumatic Brain Injury (TBI), Article, Temporal lobe, lcsh:RC321-571, 03 medical and health sciences, Brain trauma, Clinical Research, Seizures, medicine, Humans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Traumatic Head and Spine Injury, Neurology & Neurosurgery, business.industry, Prevention, Neurosciences, Epilepsy, Post-Traumatic, medicine.disease, Brain Disorders, 4.1 Discovery and preclinical testing of markers and technologies, 030104 developmental biology, Brain Injuries, Post-Traumatic, business, 030217 neurology & neurosurgery
Abstract

OBJECTIVE: Injury severity after traumatic brain injury (TBI) is a well-established risk factor for the development of post-traumatic epilepsy (PTE). However, whether lesion location influences the susceptibility of seizures and development of PTE longitudinally has yet to be defined. We hypothesized that lesion location, specifically in the temporal lobe, would be associated with an increased incidence of both early seizures and PTE. As secondary analysis measures, we assessed the degree of brain atrophy and functional recovery, and performed a between-group analysis, comparing patients who developed PTE with those who did not develop PTE. METHODS: We assessed early seizure incidence (n = 90) and longitudinal development of PTE (n = 46) in a prospective convenience sample of patients with moderate-severe TBI. Acutely, patients were monitored with prospective cEEG and a high-resolution Magnetic Resonance Imaging (MRI) scan for lesion location classification. Chronically, patients underwent a high-resolution MRI, clinical assessment, and were longitudinally monitored for development of epilepsy for a minimum of 2 years post-injury. RESULTS: Early seizures, occurring within the first week post-injury, occurred in 26.7% of the patients (n = 90). Within the cohort of subjects who had evidence of early seizures (n = 24), 75% had a hemorrhagic temporal lobe injury on admission. For longitudinal analyses (n = 46), 45.7% of patients developed PTE within a minimum of 2 years post-injury. Within the cohort of subjects who developed PTE (n = 21), 85.7% had a hemorrhagic temporal lobe injury on admission and 38.1% had early (convulsive or non-convulsive) seizures on cEEG monitoring during their acute ICU stay. In a between-group analysis, patients with PTE (n = 21) were more likely than patients who did not develop PTE (n = 25) to have a hemorrhagic temporal lobe injury (p < 0.001), worse functional recovery (p = 0.003), and greater temporal lobe atrophy (p = 0.029). CONCLUSION: Our results indicate that in a cohort of patients with a moderate-severe TBI, 1) lesion location specificity (e.g. the temporal lobe) is related to both a high incidence of early seizures and longitudinal development of PTE, 2) early seizures, whether convulsive or non-convulsive in nature, are associated with an increased risk for PTE development, and 3) patients who develop PTE have greater chronic temporal lobe atrophy and worse functional outcomes, compared to those who do not develop PTE, despite matched injury severity characteristics. This study provides the foundation for a future prospective study focused on elucidating the mechanisms and risk factors for epileptogenesis.

Published
2019

38. A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City

Author

Frontera, Jennifer A., primary, Sabadia, Sakinah, additional, Lalchan, Rebecca, additional, Fang, Taolin, additional, Flusty, Brent, additional, Millar-Vernetti, Patricio, additional, Snyder, Thomas, additional, Berger, Stephen, additional, Yang, Dixon, additional, Granger, Andre, additional, Morgan, Nicole, additional, Patel, Palak, additional, Gutman, Josef, additional, Melmed, Kara, additional, Agarwal, Shashank, additional, Bokhari, Matthew, additional, Andino, Andres, additional, Valdes, Eduard, additional, Omari, Mirza, additional, Kvernland, Alexandra, additional, Lillemoe, Kaitlyn, additional, Chou, Sherry H.-Y., additional, McNett, Molly, additional, Helbok, Raimund, additional, Mainali, Shraddha, additional, Fink, Ericka L., additional, Robertson, Courtney, additional, Schober, Michelle, additional, Suarez, Jose I., additional, Ziai, Wendy, additional, Menon, David, additional, Friedman, Daniel, additional, Friedman, David, additional, Holmes, Manisha, additional, Huang, Joshua, additional, Thawani, Sujata, additional, Howard, Jonathan, additional, Abou-Fayssal, Nada, additional, Krieger, Penina, additional, Lewis, Ariane, additional, Lord, Aaron S., additional, Zhou, Ting, additional, Kahn, D. Ethan, additional, Czeisler, Barry M., additional, Torres, Jose, additional, Yaghi, Shadi, additional, Ishida, Koto, additional, Scher, Erica, additional, de Havenon, Adam, additional, Placantonakis, Dimitris, additional, Liu, Mengling, additional, Wisniewski, Thomas, additional, Troxel, Andrea B., additional, Balcer, Laura, additional, and Galetta, Steven, additional

Published
2020
Full Text
View/download PDF

39. NeuroCOVID: it's time to join forces globally

Author

Helbok, Raimund, primary, Chou, Sherry Hsiang-Yi, additional, Beghi, Ettore, additional, Mainali, Shraddha, additional, Frontera, Jennifer, additional, Robertson, Courtney, additional, Fink, Ericka, additional, Schober, Michelle, additional, Moro, Elena, additional, McNett, Molly, additional, and Bassetti, Claudio L, additional

Published
2020
Full Text
View/download PDF

40. Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity.

Author

Francoeur, Conall, Alcamo, Alicia M., Robertson, Courtney L., Wainwright, Mark S., Roa, Juan D., Lovett, Marlina E., Stulce, Casey, Yacoub, Mais, Potera, Renee M., Zivick, Elizabeth, Holloway, Adrian, Nagpal, Ashish, Wellnitz, Kari, Even, Katelyn M., Brunow de Carvalho, Werther, Rodriguez, Isadora S., Schwartz, Stephanie P., Walker, Tracie C., Campos-Miño, Santiago, and Dervan, Leslie A.

Published
2024
Full Text
View/download PDF

46. Administration of a 20-HETE synthesis inhibitor improves outcome in a rat model of pediatric traumatic brain injury

Author

Shu, Shiyu, Zhang, Zhi, Spicer, Dawn, Kulikowicz, Ewa, Hu, Ke, Babapoor-Farrokhran, Savalan, Kannan, Sujatha, Koehler, Raymond C., and Robertson, Courtney L.

Subjects
Inflammation, Male, Rats, Sprague-Dawley, Disease Models, Animal, Reperfusion Injury, Brain Injuries, Traumatic, Hydroxyeicosatetraenoic Acids, Amidines, Animals, Brain, Cytokines, Article
Abstract

The arachidonic acid pathway metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to ischemia/reperfusion brain injury. Inhibition of 20-HETE formation can protect the developing brain from global ischemia. Here, we examined whether treatment with the 20-HETE synthesis inhibitor N-hydroxy-N-4-butyl-2-methylphenylformamidine (HET0016) can protect the immature brain from traumatic brain injury (TBI). Male rats at postnatal day 9-10 underwent controlled cortical impact followed by intraperitoneal injection with vehicle or HET0016 (1 mg/kg, 5 min and 3 h post-injury). HET0016 decreased the lesion volume by over 50% at 3 days of recovery, and this effect persisted at 30 days as the brain matured. HET0016 decreased peri-lesion gene expression of proinflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin-1β [IL-1β]) at 1 day and increased reparative cytokine (IL-4, IL-10) expression at 3 days. It also partially preserved microglial ramified processes, consistent with less activation. HET0016 decreased contralateral hindlimb foot faults and improved outcome on the novel object recognition memory task 30 days after TBI. In cultured BV2 microglia, HET0016 attenuated the lipopolysaccharide-evoked increase in release of TNF-α. Our data show that HET0016 improves acute and long-term histologic and functional outcomes, in association with an attenuated neuroinflammatory response after contusion of an immature rat brain.

Published
2019

47. Robertson_supplementary_tables_1 – Supplemental material for The Impact of Externally Worn Diabetes Technology on Sexual Behavior and Activity, Body Image, and Anxiety in Type 1 Diabetes

Author

Robertson, Courtney, Lin, Ashleigh, Smith, Grant, Yeung, Anna, Strauss, Penelope, Nicholas, Jennifer, Davis, Elizabeth, Jones, Tim, Gibson, Lisa, Richters, Juliet, and Bock, Martin De

Subjects
111708 Health and Community Services, FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, Medicine, FOS: Health sciences, 110306 Endocrinology
Abstract

Supplemental material, Robertson_supplementary_tables_1 for The Impact of Externally Worn Diabetes Technology on Sexual Behavior and Activity, Body Image, and Anxiety in Type 1 Diabetes by Courtney Robertson, Ashleigh Lin, Grant Smith, Anna Yeung, Penelope Strauss, Jennifer Nicholas, Elizabeth Davis, Tim Jones, Lisa Gibson, Juliet Richters and Martin de Bock in Journal of Diabetes Science and Technology

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results