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164 results on '"Robinson, Victoria L."'

1. Integrating Technology during Student Teaching: An Examination of Teacher Work Samples

Author

Henning, John E., Robinson, Victoria L., Herring, Mary Corwin, and McDonald, Terri

Abstract

This study examined the teacher work samples of 197 student teachers to determine their level of technology integration during student teaching. Findings indicated that most student teachers planned to use some kind of technology, although only 40% planned to include computers and less than 20% planned for the use of computers by students. The barriers to technology integration were most often related to instruction (e.g., the technology did not serve the learning goals and the technology was not developmentally appropriate) rather than a lack of available resources and time. These findings may be explained in part by the unique character of the teacher work sample (TWS) data, which prompts student teachers to report on their technology use during a single unit of instruction. (Contains 2 tables and 2 figures.)

Published
2007

7. The Basic Biology of Metastasis

Author

Robinson, Victoria L., Kauffman, Eric C., Sokoloff, Mitchell H., Rinker-Schaeffer, Carrie W., Rosen, Steven T., editor, Keller, Evan T., editor, and Chung, Leland W. K., editor

Published
2004
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8. Jagged Edges of the Glass Ceiling

Author

Robinson, Victoria L.

Abstract

Although many aspiring young women might believe the glass ceiling was shattered a decade ago, they still need to understand how that glass ceiling impacted an older generation of women in educational leadership. They also must be aware that some segments of the glass ceiling might still exist. This article provides a historical overview of the external barriers faced by women in educational leadership and presents mentoring recommendations to both generations.

Published
2004

15. Salmonella enterica serovar Typhimurium BipA exhibits two distinct ribosome binding modes

Author

deLivron, Megan A. and Robinson, Victoria L.

Subjects
Salmonella -- Physiological aspects, Salmonella -- Genetic aspects, Salmonella -- Research, Guanosine triphosphatase -- Health aspects, Guanosine triphosphatase -- Genetic aspects, Guanosine triphosphatase -- Research, Protein binding -- Research, Ribosomal proteins -- Physiological aspects, Ribosomal proteins -- Research, Biological sciences
Abstract

BipA is a highly conserved prokaryotic GTPase that functions to influence numerous cellular processes in bacteria. In Escherichia coli and Salmonella enterica serovar Typhimurium, BipA has been implicated in controlling bacterial motility, modulating attachment and effacement processes, and upregulating the expression of virulence genes and is also responsible for avoidance of host defense mechanisms. In addition, BipA is thought to be involved in bacterial stress responses, such as those associated with virulence, temperature, and symbiosis. Thus, BipA is necessary for securing bacterial survival and successful invasion of the host. Steady-state kinetic analysis and pelleting assays were used to assess the GTPase and ribosome-binding properties of S. enterica BipA. Under normal bacterial growth, BipA associates with the ribosome in the GTP-bound state. However, using sucrose density gradients, we demonstrate that the association of BipA and the ribosome is altered under stress conditions in bacteria similar to those experienced during virulence. The data show that this differential binding is brought about by the presence of ppGpp, an alarmone that signals the onset of stress-related events in bacteria.

Published
2008

16. Phenotypic characterization of a virulence-associated protein, VagH, of Yersinia pseudotuberculosis reveals a tight link between VagH and the type III secretion system

Author

Garbom, Sara, Olofsson, Martina, Bjornfot, Ann-Catrin, Srivastava, Manoj Kumar, Robinson, Victoria L., Oyston, Petra C.F., Titball, Richard W., and Wolf-Watz, Hans

Subjects
Phenotype, Proteins, Pseudotuberculosis, Yersinia, Biological sciences
Abstract

Recently, a number of attenuated mutants of Yersinia pseudotuberculosis have been identified using a bioinformatics approach. One of the target genes identified in that study was vagH, which the authors now characterized further. VagH shows homology to HemK of Escherichia coli, possessing methyltransferase activity similar to that of HemK, and targeting release factors 1 and 2. Microarray studies comparing the wild-type and the vagH mutant revealed that the mRNA levels of only a few genes were altered in the mutant. By proteome analysis, expression of the virulence determinant YopD was found to be increased, indicating a possible connection between VagH and the virulence plasmid-encoded type III secretion system (T3SS). Further analysis showed that Yop expression and secretion were repressed in a vagH mutant. This phenotype could be suppressed by trans-complementation with the wild-type vagH gene or by deletion of the negative regulator yopD. Also, in a similar manner to a T3SS-negative mutant, the avirulent vagH mutant was rapidly cleared from Peyer's patches and could not reach the spleen after oral infection of mice. In a manner analogous to that of T3SS mutants, the vagH mutant could not block phagocytosis by macrophages. However, a vagH mutant showed no defects in the T3SS-independent ability to proliferate intracellularly and replicated to levels similar to those of the wild-type in macrophages. In conclusion, the vagH mutant exhibits a virulence phenotype similar to that of a T3SS-negative mutant, indicating a tight link between VagH and type III secretion in Y. pseudotuberculosis. DOI 10.1099/mic.0.2006/000323-0

Published
2007

19. Two-component signal transduction

Author

Stock, Ann M., Robinson, Victoria L., and Goudreau, Paul N.

Subjects
Cellular signal transduction -- Research, Protein kinases -- Physiological aspects, Histidine -- Physiological aspects, Enzymes -- Regulation, Phosphorylation -- Physiological aspects, Proteins -- Conformation, Biological sciences
Abstract

The signal-transduction systems in prokaryotic and eukaryotic systems and the differences in the composition of the pathway components in each systems are reviewed. Data reveal that over-all the pathway shows a two-component configuration consisting of a histidine protein kinase and a response regulator protein.

Published
2000

21. FYN is overexpressed in human prostate cancer

Author

Posadas, Edwin M., Al-Ahmadie, Hikmat, Robinson, Victoria L., Jagadeeswaran, Ramasamy, Otto, Kristen, Kasza, Kristen E., Tretiakov, Maria, Siddiqui, Javed, Pienta, Kenneth J., Stadler, Walter M., Rinker-Schaeffer, Carrie, and Salgia, Ravi

Published
2009

26. A novel domain in translational GTPase BipA mediates interaction with the 70S ribosome and influences GTP hydrolysis

Author

deLivron, Megan A., Makanji, Heeren S., Lane, Maura C., and Robinson, Victoria L.

Subjects
Guanosine triphosphatase -- Structure, Guanosine triphosphatase -- Chemical properties, Protein binding -- Analysis, Ribosomes -- Chemical properties, Genetic translation -- Analysis, Biological sciences, Chemistry
Abstract

Several data analyses are conducted to explain the contribution of the domains of the translational GTPase BipA in determining the biological properties of the protein. The GTPase activities are shown to be highly related to the ribosome binding of the protein.

Published
2009

28. A pH-dependent aquomet-to-hemichrome transition in crystalline horse methemoglobin

Author

Robinson, Victoria L., smith, Benjamin B., and Arnone, Arthur

Subjects
Structure-activity relationships (Biochemistry) -- Analysis, Hemoproteins -- Physiological aspects, Hydrogen-ion concentration -- Physiological aspects, Hydrogen-ion concentration -- Influence, Hemoglobin, Biological sciences, Chemistry
Abstract

Crystal structures of the crystalline horse methemoglobin at pH 7.1 and 5.4 at 1.6 and 2.1 angstroms, respectively, are described. Data reveal that during the pH transition from basic to acidic, the iron alpha heme groups are transformed from the aquomet to the hemichrome form, which leads to tertiary structure transition in an eight-residue segment of the enzyme.

Published
2003

35. Loss of the Urothelial Differentiation Marker FOXA1 Is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation

Author

DeGraff, David J., primary, Clark, Peter E., additional, Cates, Justin M., additional, Yamashita, Hironobu, additional, Robinson, Victoria L., additional, Yu, Xiuping, additional, Smolkin, Mark E., additional, Chang, Sam S., additional, Cookson, Michael S., additional, Herrick, Mary K., additional, Shariat, Shahrokh F., additional, Steinberg, Gary D., additional, Frierson, Henry F., additional, Wu, Xue-Ru, additional, Theodorescu, Dan, additional, and Matusik, Robert J., additional

Published
2012
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40. S1698 MiR-143 and miR-145 are Differentially Expressed in the Right and Left Colon and Likely Regulate Differential Expression of K-RAS and Irs-1: Implications for Colon Cancer

Author

Pekow, Joel, primary, Dougherty, Urszula, additional, Zhu, Hongyan, additional, Robinson, Victoria L., additional, Mustafi, Reba, additional, Venu, Nanda, additional, Kim, Karen E., additional, Joseph, Loren J., additional, Fichera, Alessandro, additional, and Bissonnette, Marc, additional

Published
2010
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44. FYN is overexpressed in human prostate cancer

Author

Posadas, Edwin M., primary, Al‐Ahmadie, Hikmat, additional, Robinson, Victoria L., additional, Jagadeeswaran, Ramasamy, additional, Otto, Kristen, additional, Kasza, Kristen E., additional, Tretiakov, Maria, additional, Siddiqui, Javed, additional, Pienta, Kenneth J., additional, Stadler, Walter M., additional, Rinker‐Schaeffer, Carrie, additional, and Salgia, Ravi, additional

Published
2008
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