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1,038 results on '"Roccaro, Aldo M."'

2. Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia

Author

Dogliotti, Irene, Jiménez, Cristina, Varettoni, Marzia, Talaulikar, Dipti, Bagratuni, Tina, Ferrante, Martina, Pérez, José, Drandi, Daniela, Puig, Noemí, Gilestro, Milena, García-Álvarez, María, Owen, Roger, Jurczak, Wojciech, Tedeschi, Alessandra, Leblond, Veronique, Kastritis, Efstathios, Kersten, Marie José, D’Sa, Shirley, Kaščák, Michal, Willenbacher, Wolfgang, Roccaro, Aldo M., Poulain, Stephanie, Morel, Pierre, Kyriakou, Charalampia, Fend, Falko, Vos, Josephine M. I., Dimopoulos, Meletios A., Buske, Christian, Ferrero, Simone, and García-Sanz, Ramón

Published
2023
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3. Targeting the immune microenvironment in Waldenström macroglobulinemia via halting the CD40/CD40-ligand axis

Author

Sacco, Antonio, Desantis, Vanessa, Celay, Jon, Giustini, Viviana, Rigali, Fabio, Savino, Francesco D., Cea, Michele, Soncini, Debora, Cagnetta, Antonia, Solimando, Antonio G., D’Aliberti, Deborah, Spinelli, Silvia, Ramazzotti, Daniele, Almici, Camillo, Todoerti, Katia, Neri, Antonino, Anastasia, Antonella, Tucci, Alessandra, Motta, Marina, Chiarini, Marco, Kawano, Yawara, Martinez-Climent, Jose A., Piazza, Rocco, and Roccaro, Aldo M.

Published
2023
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5. SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response

Author

Alberici, Federico, Affatato, Stefania, Moratto, Daniele, Mescia, Federica, Delbarba, Elisa, Guerini, Alice, Tedesco, Martina, Burbelo, Peter D., Zani, Roberta, Castagna, Ilaria, Gallico, Agnese, Tonoli, Mattia, Venturini, Margherita, Roccaro, Aldo M., Giacomelli, Mauro, Cohen, Jeffrey I., Giustini, Viviana, Dobbs, Kerry, Su, Helen C., Fiorini, Chiara, Quaresima, Virginia, Viola, Fabio Battista, Vizzardi, Valerio, Gaggiotti, Mario, Bossini, Nicola, Gaggia, Paola, Badolato, Raffaele, Notarangelo, Luigi D., Chiarini, Marco, and Scolari, Francesco

Published
2022
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6. Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia

Author

Morelli, Eugenio, Hunter, Zachary R., Fulciniti, Mariateresa, Gullà, Annamaria, Perrotta, Ida Daniela, Zuccalà, Valeria, Federico, Cinzia, Juli, Giada, Manzoni, Martina, Ronchetti, Domenica, Romeo, Enrica, Gallo Cantafio, Maria Eugenia, Soncini, Debora, Maltese, Lorenza, Rossi, Marco, Roccaro, Aldo M., Cea, Michele, Tassone, Pierfrancesco, Neri, Antonino, Treon, Steven C., Munshi, Nikhil C., Viglietto, Giuseppe, and Amodio, Nicola

Published
2022
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8. Editor's Note: Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia

Author

Azab, Feda, primary, Azab, Abdel Kareem, additional, Maiso, Patricia, additional, Calimeri, Teresa, additional, Flores, Ludmila, additional, Liu, Yang, additional, Quang, Phong, additional, Roccaro, Aldo M., additional, Sacco, Antonio, additional, Ngo, Hai T., additional, Zhang, Yong, additional, Morgan, Brittany L., additional, Carrasco, Ruben D., additional, and Ghobrial, Irene M., additional

Published
2024
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13. Epigenetics in Multiple Myeloma

Author

Glavey, Siobhan V., Manier, Salomon, Sacco, Antonio, Salem, Karma, Kawano, Yawara, Bouyssou, Juliette, Ghobrial, Irene M., Roccaro, Aldo M., Rosen, Steven T., Series editor, Roccaro, Aldo M., editor, and Ghobrial, Irene M., editor

Published
2016
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14. Vascular and Stromal Contributions to Tumor Bone-Homing: Focus on Multiple Myeloma

Author

Federico, Cinzia, primary, Sacco, Antonio, additional, Belotti, Angelo, additional, Ribolla, Rossella, additional, Cancelli, Valeria, additional, Giacomini, Arianna, additional, Ronca, Roberto, additional, Chiarini, Marco, additional, Imberti, Luisa, additional, Marini, Mirella, additional, Rossi, Giuseppe, additional, Presta, Marco, additional, and Roccaro, Aldo M., additional

Published
2020
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17. Prognostic role of circulating exosomal miRNAs in multiple myeloma

Author

Manier, Salomon, Liu, Chia-Jen, Avet-Loiseau, Hervé, Park, Jihye, Shi, Jiantao, Campigotto, Federico, Salem, Karma Z., Huynh, Daisy, Glavey, Siobhan V., Rivotto, Bradley, Sacco, Antonio, Roccaro, Aldo M., Bouyssou, Juliette, Minvielle, Stéphane, Moreau, Philippe, Facon, Thierry, Leleu, Xavier, Weller, Edie, Trippa, Lorenzo, and Ghobrial, Irene M.

Published
2017
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18. Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression

Author

Kawano, Yawara, Zavidij, Oksana, Park, Jihye, Moschetta, Michele, Kokubun, Katsutoshi, Mouhieddine, Tarek H., Manier, Salomon, Mishima, Yuji, Murakami, Naoka, Bustoros, Mark, Pistofidis, Romanos Sklavenitis, Reidy, Mairead, Shen, Yu.J., Rahmat, Mahshid, Lukyanchykov, Pavlo, Karreci, Esilida Sula, Tsukamoto, Shokichi, Shi, Jiantao, Takagi, Satoshi, Huynh, Daisy, Sacco, Antonio, Tai, Yu-Tzu, Chesi, Marta, Bergsagel, P. Leif, Roccaro, Aldo M., Azzi, Jamil, and Ghobrial, Irene M.

Subjects
Cancer research, Multiple myeloma -- Development and progression, Immunotherapy -- Research, Interferon -- Physiological aspects -- Health aspects, Cytokine receptors -- Health aspects, T cells -- Physiological aspects -- Health aspects, Health care industry
Abstract

Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive mechanisms that is believed to play a role in myeloma progression is the expansion of regulatory T cells (Tregs). In this study, we demonstrate that myeloma cells drive Treg expansion and activation by secreting type 1 interferon (IFN). Blocking IFN [alpha] and [beta] receptor 1 (IFNAR1) on Tregs significantly decreases both myeloma-associated Treg immunosuppressive function and myeloma progression. Using syngeneic transplantable murine myeloma models and bone marrow (BM) aspirates of MM patients, we found that Tregs were expanded and activated in the BM microenvironment at early stages of myeloma development. Selective depletion of Tregs led to a complete remission and prolonged survival in mice injected with myeloma cells. Further analysis of the interaction between myeloma cells and Tregs using gene sequencing and enrichment analysis uncovered a feedback loop, wherein myeloma-cell-secreted type 1 IFN induced proliferation and expansion of Tregs. By using IFNAR1-blocking antibody treatment and IFNAR1-knockout Tregs, we demonstrated a significant decrease in myeloma-associated Treg proliferation, which was associated with longer survival of myeloma-injected mice. Our results thus suggest that blocking type 1 IFN signaling represents a potential strategy to target immunosuppressive Treg function in MM., Introduction Immunotherapy has shown promising results in clinical trials against both solid (1) and hematological malignancies (2), such as Hodgkin lymphoma (3). Even though targeting the immune microenvironment can lead [...]

Published
2018
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19. Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche

Author

Tsukamoto, Shokichi, Løvendorf, Marianne B., Park, Jihye, Salem, Karma Z., Reagan, Michaela R., Manier, Salomon, Zavidij, Oksana, Rahmat, Mahshid, Huynh, Daisy, Takagi, Satoshi, Kawano, Yawara, Kokubun, Katsutoshi, Thrue, Charlotte Albæk, Nagano, Kenichi, Petri, Andreas, Roccaro, Aldo M., Capelletti, Marzia, Baron, Roland, Kauppinen, Sakari, and Ghobrial, Irene M.

Published
2018
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20. Data from ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment

Author

Bianchi, Giada, primary, Czarnecki, Peter G., primary, Ho, Matthew, primary, Roccaro, Aldo M., primary, Sacco, Antonio, primary, Kawano, Yawara, primary, Gullà, Annamaria, primary, Samur, Anil Aktas, primary, Chen, Tianzeng, primary, Wen, Kenneth, primary, Tai, Yu-Tzu, primary, Moscvin, Maria, primary, Wu, Xinchen, primary, Camci-Unal, Gulden, primary, Da Vià, Matteo C., primary, Bolli, Niccolo', primary, Sewastianik, Tomasz, primary, Carrasco, Ruben D., primary, Ghobrial, Irene M., primary, and Anderson, Kenneth C., primary

Published
2023
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21. Supplementary Methods from ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment

Author

Bianchi, Giada, primary, Czarnecki, Peter G., primary, Ho, Matthew, primary, Roccaro, Aldo M., primary, Sacco, Antonio, primary, Kawano, Yawara, primary, Gullà, Annamaria, primary, Samur, Anil Aktas, primary, Chen, Tianzeng, primary, Wen, Kenneth, primary, Tai, Yu-Tzu, primary, Moscvin, Maria, primary, Wu, Xinchen, primary, Camci-Unal, Gulden, primary, Da Vià, Matteo C., primary, Bolli, Niccolo', primary, Sewastianik, Tomasz, primary, Carrasco, Ruben D., primary, Ghobrial, Irene M., primary, and Anderson, Kenneth C., primary

Published
2023
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22. Supplementary Figures 1-15, Supplementary Table 1 from ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment

Author

Bianchi, Giada, primary, Czarnecki, Peter G., primary, Ho, Matthew, primary, Roccaro, Aldo M., primary, Sacco, Antonio, primary, Kawano, Yawara, primary, Gullà, Annamaria, primary, Samur, Anil Aktas, primary, Chen, Tianzeng, primary, Wen, Kenneth, primary, Tai, Yu-Tzu, primary, Moscvin, Maria, primary, Wu, Xinchen, primary, Camci-Unal, Gulden, primary, Da Vià, Matteo C., primary, Bolli, Niccolo', primary, Sewastianik, Tomasz, primary, Carrasco, Ruben D., primary, Ghobrial, Irene M., primary, and Anderson, Kenneth C., primary

Published
2023
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23. Supplementary Figure from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Author

Termini, Rosalinda, primary, Žihala, David, primary, Terpos, Evangelos, primary, Perez-Montaña, Albert, primary, Jelínek, Tomáš, primary, Raab, Marc, primary, Weinhold, Niels, primary, Mai, Elias K., primary, Grab, Anna Luise, primary, Corre, Jill, primary, Vergez, Francois, primary, Sacco, Antonio, primary, Chiarini, Marco, primary, Giustini, Viviana, primary, Tucci, Alessandra, primary, Rodriguez, Sara, primary, Moreno, Cristina, primary, Perez, Cristina, primary, Maia, Catarina, primary, Martín-Sánchez, Esperanza, primary, Guerrero, Camilla, primary, Botta, Cirino, primary, Garces, Juan-Jose, primary, Lopez, Aitziber, primary, Tamariz-Amador, Luis-Esteban, primary, Prosper, Felipe, primary, Bargay, Joan, primary, Cabezudo, Maria-Elena, primary, Ocio, Enrique M., primary, Hájek, Roman, primary, Martinez-Lopez, Joaquin, primary, Solano, Fernando, primary, Iglesias, Rebeca, primary, Paiva, Artur, primary, Geraldes, Catarina, primary, Vitoria, Helena, primary, Gomez, Clara, primary, De Arriba, Felipe, primary, Ludwig, Heinz, primary, Garcia-Guiñon, Antoni, primary, Casanova, Maria, primary, Alegre, Adrian, primary, Cabañas, Valentin, primary, Sirvent, Maialen, primary, Oriol, Albert, primary, de la Rubia, Javier, primary, Hernández-Rivas, José-Ángel, primary, Palomera, Luis, primary, Sarasa, Maria, primary, Rios, Pablo, primary, Puig, Noemi, primary, Mateos, Maria-Victoria, primary, Flores-Montero, Juan, primary, Orfao, Alberto, primary, Goldschmidt, Hartmut, primary, Avet-Loiseau, Hervé, primary, Roccaro, Aldo M., primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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24. Supplementary Table from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Author

Termini, Rosalinda, primary, Žihala, David, primary, Terpos, Evangelos, primary, Perez-Montaña, Albert, primary, Jelínek, Tomáš, primary, Raab, Marc, primary, Weinhold, Niels, primary, Mai, Elias K., primary, Grab, Anna Luise, primary, Corre, Jill, primary, Vergez, Francois, primary, Sacco, Antonio, primary, Chiarini, Marco, primary, Giustini, Viviana, primary, Tucci, Alessandra, primary, Rodriguez, Sara, primary, Moreno, Cristina, primary, Perez, Cristina, primary, Maia, Catarina, primary, Martín-Sánchez, Esperanza, primary, Guerrero, Camilla, primary, Botta, Cirino, primary, Garces, Juan-Jose, primary, Lopez, Aitziber, primary, Tamariz-Amador, Luis-Esteban, primary, Prosper, Felipe, primary, Bargay, Joan, primary, Cabezudo, Maria-Elena, primary, Ocio, Enrique M., primary, Hájek, Roman, primary, Martinez-Lopez, Joaquin, primary, Solano, Fernando, primary, Iglesias, Rebeca, primary, Paiva, Artur, primary, Geraldes, Catarina, primary, Vitoria, Helena, primary, Gomez, Clara, primary, De Arriba, Felipe, primary, Ludwig, Heinz, primary, Garcia-Guiñon, Antoni, primary, Casanova, Maria, primary, Alegre, Adrian, primary, Cabañas, Valentin, primary, Sirvent, Maialen, primary, Oriol, Albert, primary, de la Rubia, Javier, primary, Hernández-Rivas, José-Ángel, primary, Palomera, Luis, primary, Sarasa, Maria, primary, Rios, Pablo, primary, Puig, Noemi, primary, Mateos, Maria-Victoria, primary, Flores-Montero, Juan, primary, Orfao, Alberto, primary, Goldschmidt, Hartmut, primary, Avet-Loiseau, Hervé, primary, Roccaro, Aldo M., primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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25. Supplementary Data from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Author

Termini, Rosalinda, primary, Žihala, David, primary, Terpos, Evangelos, primary, Perez-Montaña, Albert, primary, Jelínek, Tomáš, primary, Raab, Marc, primary, Weinhold, Niels, primary, Mai, Elias K., primary, Grab, Anna Luise, primary, Corre, Jill, primary, Vergez, Francois, primary, Sacco, Antonio, primary, Chiarini, Marco, primary, Giustini, Viviana, primary, Tucci, Alessandra, primary, Rodriguez, Sara, primary, Moreno, Cristina, primary, Perez, Cristina, primary, Maia, Catarina, primary, Martín-Sánchez, Esperanza, primary, Guerrero, Camilla, primary, Botta, Cirino, primary, Garces, Juan-Jose, primary, Lopez, Aitziber, primary, Tamariz-Amador, Luis-Esteban, primary, Prosper, Felipe, primary, Bargay, Joan, primary, Cabezudo, Maria-Elena, primary, Ocio, Enrique M., primary, Hájek, Roman, primary, Martinez-Lopez, Joaquin, primary, Solano, Fernando, primary, Iglesias, Rebeca, primary, Paiva, Artur, primary, Geraldes, Catarina, primary, Vitoria, Helena, primary, Gomez, Clara, primary, De Arriba, Felipe, primary, Ludwig, Heinz, primary, Garcia-Guiñon, Antoni, primary, Casanova, Maria, primary, Alegre, Adrian, primary, Cabañas, Valentin, primary, Sirvent, Maialen, primary, Oriol, Albert, primary, de la Rubia, Javier, primary, Hernández-Rivas, José-Ángel, primary, Palomera, Luis, primary, Sarasa, Maria, primary, Rios, Pablo, primary, Puig, Noemi, primary, Mateos, Maria-Victoria, primary, Flores-Montero, Juan, primary, Orfao, Alberto, primary, Goldschmidt, Hartmut, primary, Avet-Loiseau, Hervé, primary, Roccaro, Aldo M., primary, San-Miguel, Jesus F., primary, and Paiva, Bruno, primary

Published
2023
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26. Fig S6 from Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Author

Takagi, Satoshi, primary, Tsukamoto, Shokichi, primary, Park, Jihye, primary, Johnson, Kelly E., primary, Kawano, Yawara, primary, Moschetta, Michele, primary, Liu, Chia-Jen, primary, Mishima, Yuji, primary, Kokubun, Katsutoshi, primary, Manier, Salomon, primary, Salem, Karma Z., primary, Huynh, Daisy, primary, Sacco, Antonio, primary, Forward, Jodi, primary, Roccaro, Aldo M., primary, Battinelli, Elisabeth M., primary, and Ghobrial, Irene M., primary

Published
2023
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27. Data from FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative Stress

Author

Ronca, Roberto, primary, Ghedini, Gaia C., primary, Maccarinelli, Federica, primary, Sacco, Antonio, primary, Locatelli, Silvia L., primary, Foglio, Eleonora, primary, Taranto, Sara, primary, Grillo, Elisabetta, primary, Matarazzo, Sara, primary, Castelli, Riccardo, primary, Paganini, Giuseppe, primary, Desantis, Vanessa, primary, Cattane, Nadia, primary, Cattaneo, Annamaria, primary, Mor, Marco, primary, Carlo-Stella, Carmelo, primary, Belotti, Angelo, primary, Roccaro, Aldo M., primary, Presta, Marco, primary, and Giacomini, Arianna, primary

Published
2023
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28. Supplementary Table 1 from Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Author

Takagi, Satoshi, primary, Tsukamoto, Shokichi, primary, Park, Jihye, primary, Johnson, Kelly E., primary, Kawano, Yawara, primary, Moschetta, Michele, primary, Liu, Chia-Jen, primary, Mishima, Yuji, primary, Kokubun, Katsutoshi, primary, Manier, Salomon, primary, Salem, Karma Z., primary, Huynh, Daisy, primary, Sacco, Antonio, primary, Forward, Jodi, primary, Roccaro, Aldo M., primary, Battinelli, Elisabeth M., primary, and Ghobrial, Irene M., primary

Published
2023
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29. Supplementary Data from FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative Stress

Author

Ronca, Roberto, primary, Ghedini, Gaia C., primary, Maccarinelli, Federica, primary, Sacco, Antonio, primary, Locatelli, Silvia L., primary, Foglio, Eleonora, primary, Taranto, Sara, primary, Grillo, Elisabetta, primary, Matarazzo, Sara, primary, Castelli, Riccardo, primary, Paganini, Giuseppe, primary, Desantis, Vanessa, primary, Cattane, Nadia, primary, Cattaneo, Annamaria, primary, Mor, Marco, primary, Carlo-Stella, Carmelo, primary, Belotti, Angelo, primary, Roccaro, Aldo M., primary, Presta, Marco, primary, and Giacomini, Arianna, primary

Published
2023
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30. Supplementary Table Legend from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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32. Supplementary Table from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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33. Supplementary Figure 5 from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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34. Supplementary Figure 1 from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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35. Supplementary Figure Legends from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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36. Supplementary Figure 2 from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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37. Supplementary Methods from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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38. Supplementary Figures S1-S3 from Carfilzomib-Dependent Selective Inhibition of the Chymotrypsin-like Activity of the Proteasome Leads to Antitumor Activity in Waldenstrom's Macroglobulinemia

Author

Sacco, Antonio, primary, Aujay, Monette, primary, Morgan, Brittany, primary, Azab, Abdel Kareem, primary, Maiso, Patricia, primary, Liu, Yang, primary, Zhang, Yong, primary, Azab, Feda, primary, Ngo, Hai T., primary, Issa, Ghayas C., primary, Quang, Phong, primary, Roccaro, Aldo M., primary, and Ghobrial, Irene M., primary

Published
2023
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40. Supplementary Figure 3 from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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41. Supplementary Figure 6 from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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43. Supplementary Figure 4 from Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Author

Moschetta, Michele, primary, Basile, Antonio, primary, Ferrucci, Arianna, primary, Frassanito, Maria Antonia, primary, Rao, Luigia, primary, Ria, Roberto, primary, Solimando, Antonio Giovanni, primary, Giuliani, Nicola, primary, Boccarelli, Angelina, primary, Fumarola, Fabio, primary, Coluccia, Mauro, primary, Rossini, Bernardo, primary, Ruggieri, Simona, primary, Nico, Beatrice, primary, Maiorano, Eugenio, primary, Ribatti, Domenico, primary, Roccaro, Aldo M., primary, and Vacca, Angelo, primary

Published
2023
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49. Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia

Author

International Waldenstrom's Macroglobulinemia Foundation, Dogliotti, Irene, Jiménez, Cristina, Talaulikar, Dipti, Bagratuni, Tina, Ferrante, Martina, Pérez, José, Drandi, Daniela, Puig, Noemi, Gilestro, Milena, García-Alvarez, María, Owen, Roger, Jurczak, Wojciech, Tedeschi, Alessandra, Leblond, Véronique, Kastritis, Efstathios, Kersten, Marie José, D’Sa, Shirley, Kaščák, Michal, Willenbacher, Wolfgang, Roccaro, Aldo M., Poulain, Stephanie, Morel, Pierre, Kyriakou, Charalampia, Fend, Falko, Vos, Josephine M. I., Dimopoulos, Meletios A., Buske, Christian, Ferrero, Simone, García-Sanz, Ramón, International Waldenstrom's Macroglobulinemia Foundation, Dogliotti, Irene, Jiménez, Cristina, Talaulikar, Dipti, Bagratuni, Tina, Ferrante, Martina, Pérez, José, Drandi, Daniela, Puig, Noemi, Gilestro, Milena, García-Alvarez, María, Owen, Roger, Jurczak, Wojciech, Tedeschi, Alessandra, Leblond, Véronique, Kastritis, Efstathios, Kersten, Marie José, D’Sa, Shirley, Kaščák, Michal, Willenbacher, Wolfgang, Roccaro, Aldo M., Poulain, Stephanie, Morel, Pierre, Kyriakou, Charalampia, Fend, Falko, Vos, Josephine M. I., Dimopoulos, Meletios A., Buske, Christian, Ferrero, Simone, and García-Sanz, Ramón

Abstract

The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.

Published
2023

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